http://pistoiaalliance.org

Richard BoltonStrategy for IT and Portfolio for Discovery, GSKELN Query Services workstream Coordinator, Pistoia

Pistoia Alliance ConferenceBoston, MA – April 12th 2011

The Pistoia AllianceChemistry Live Strategy

Recap: Pistoia Mission & Vision

Lowering the barriers to innovation

by improving inter-operability of R&D business processes

through pre competitive collaboration

Pistoia Activity Domains

Biology/Translational

Research“Understanding Disease”

Chemistry Live

“Linking Structure with Outcome”

Scientific Collaboration

What am I going to cover today…

• Current Industry trends and changes that are impacting the Chemistry space.

• Introduction to Chemistry Live concept

• Two possible use cases reviewed– ELN query standards and hosted ELN– Chemistry Externalisation process

facilitation• Discussion

What’s happening in big Pharma that’s impacting the Chemistry space?

• Significantly reduced cost of operation• The operating model is externalising; innovative science is

being chased regardless of geographic location.• Many more joint ventures, partnerships and alliances are

forming.• CRO’s are potentially being engaged to provide both directed

synthesis and end-to-end research services• New companies are being spun out from existing research

programmes.• Work previously undertaken ‘under one roof’ is now widely

distributed around the world. • Sample logistics crosses international borders.• Hosted and Cloud based software and storage solutions are

being embraced.• SaaS/IaaS etc models are all gaining ground where they are

cost effective• Appropriate data accessibility is seen as a key to success.

What is Chemistry Live?

• A programme of work outlining how Pistoia could help to facilitate pre-competitive change and to showcase Pistoia ambition in the Chemistry area.

• Work packages will be developed and will look for sponsorship from members.

• Likely no more than 2 workstreams will be run at any time.

Pistoia StrategyELN Query Standard and

hosted ELN

ELN ‘Electronic Lab Notebook’

ELN Yesterday….

• Focus on IP protection

• Client Server setup behind a firewall

• Little integration between systems.

• No ability to query systems from outside native clients

• Partners using non compatible systems (often paper based systems)

ELN Today….

• Need for partners to use ELN to manage IP.

• Existing ELN’s being shared using various workarounds (Citrix virtualisation, deployment of ELN at partner site etc)

• Capability to query ELN’s outside native client appearing

ELN Tomorrow….

• Many private and public cloud based ELN offerings.

• CRO’s, Academics, Partners and Alliances use their own ELN systems and interchange data in standard formats.

• ELN query standards allow a mix of mart based and federated query.

• Archive and search are still separate functions

• Expectation from Scientists that the use of ELN adds significant value to workflow

How can Pistoia facilitate getting to the ELN of tomorrow sooner

• Programme of work to….– Cross Pharma program to take draft standard and

produce reference implementation– Agree one possible data structure for query datamart .– Demonstrate single interface to query across

transactional system (where vendor allows it), the meta data mart and public data set.

– Work with legal teams to ensure IP capture is acceptable

• Explain Path to Value• Produce proposed project charter• Get funding…….

ELN Query Standard and Hosted ELN

Shared needsCommon

requirements

StandardsSolutions / Services

Use Externalised solutions with partners. Access to knowledge from multiple repositories.

Participate in definition of ELN query standard.Adopt standard.

Adopt standards compliant solutionsReject non-compliant solutions?

Flexible deployment.Query across multiple sources of ELN data.Archive of experiment for 65 years

Provide common user stories.Technology agnostic

Participate in definition of standardsPublish standardsDrive adoption

Identify provider(s)Assess compliance of solutions/servicesProvide ‘label’ for compliant solutions/services

Provide forum for discussions

Understand requirements (possibly participate in generation)

Participate in definition of standardsAdopt standards

Offers interface to ELN which can be queried using standard.

Consistent product across multiple customers.Vendor can provide more functionality.Performance in transactional system

Ability to mine data from multiple sourcesLower cost of operationMore functionality

Mission accomplished

Opens new business models.

Value

Pro

vid

er

Bro

ker

Buyer

ELN Query Standard and Hosted ELN

Shared needsCommon

requirements

Use Externalised solutions with partners. Access to knowledge from multiple repositories.

Flexible deployment.Query across multiple sources of ELN data.Archive of experiment for 65 years.

Buyer

. .

• Pistoia Alliance Sponsorship• Chair: TBD• Steering Committee: all participants investing in the

project (money, resources, time).• Funding from at least 6 Pharma participants.• Vendor participation to generate Connectors to the

standard• Integrator engaged to host the reference

implementation

Expected Benefits (Value)Opportunities / Threats

Success Criteria

Stakeholders & Resource Requirements

• Identification of Pharma companies prepared to fund efforts. Identification of Vendors who wish to participate. Engagement as a steering committee.

• Development of a project team of interested parties to pull together both a more detailed plan and a cost model.

• Agreement on engagement of an integrator.• All parties agreed that major outcomes will

be• Reference implementation of Query

standard hosted by integrator for a period of 6 months

• A public data set to be used in testing

• An example of a hosted ELN.• Demonstration of the query

standard used to extract data from the hosted ELN populating a database which can be queried by the reference implementation.

• Demonstration of a scalable solution for an ELN query standard that will search across multiple data sets and vendor products.

• Demonstrate a possible architecture for a hosted ELN solution using the query standard to move information to a mart, also queried by the standard

• Publication of ELN data query standard after iteration from lessons learned from implementation.

• To demonstrate and iterate the existing draft ELN query standard to a form for publication

• To demonstrate how a hosted ELN solution can pass data back to an appropriately structured datamart using the query standard response as the data package.

• To demonstrate the query standard being used across vendor solutions, static public data and a mart from the hosted ELN.

• Participating from at least 6 Pharma companies. And one hosted ELN vendor plus 2 other ElN vendors

• Query standard reference implementation showing federated query in place by Q4 2011.

• Agreed data transfer between hosted solutions and marts by Q42011

• Demonstration of hosted ELN solution passing data back to Query Mart by Q4 2011

• ELN’s are now ubiquitous across chemistry organisations. There is expectation that partners will use ELN to provide records back to sponsoring organisations.

• Data needs to be kept for 65 years for IP protection.

• The transactional systems are becoming harder and harder to query

• Partnerships form rapidly and currently Pharma infrastructure to deliver ELN over the web cannot respond appropriately.

Business Challenge Project Objectives

Q2 11 Q4 11Q3 11Mar 11 Q1 12

M

M

Board Approval

Pilot Kick-off

Key Milestones (DRAFT example only)

Activities / Deliverables

ELN query standards and hosted ELN Charter

• Pistoia Alliance sponsored project.• Enabling activity to support key aspects on the

Pistoia Alliance Chemistry strategy.

Background

V1.0 March 2011

• Offers potential of wider model to integrate internal and hosted ELNs along with a possible data archive model

• Not enough buy-in from Pharmas and vendors• Not enough funding to complete delivery

Pistoia StrategyChemistry Externalization

Processes

Chemistry Externalization Processes• ‘Synthesis in Shanghai, screening in

Singapore’• Compounds are now being synthesised

remote from screening sites.• Physical samples do not always return to

requestor before screening and may need to cross international borders.

• How can a Pistoia standards help with requesting, tracking and results gathering?

Chemistry Externalization Processes

Chemistry Externalization Processes

Six points of data transfer

Chemistry Externalization Processes

Six points of data transfer

Three transfers of physical sample

How can Pistoia facilitate this process? • Programme of work to….

– Agree standard cross partner (Pharma/CRO/Alliance etc) processes

– Agree standards for data tracking and exchange

– Agree standards for physical sample tracking and common approaches to licensing requirements for cross-border shipping

• Explain Path to Value• Produce proposed project charter• Get funding…….

Value

Path to value.

Shared needsCommon

requirements

StandardsSolutions / Services

Document requirementsCommit to adoption of solution & standards

Participate in definition of standardsAdopt standards

Prefer compliant solutionsReject non-compliant solutions?

Document shared use casesAgree on prioritiesCommit resources

Provide common user stories.Technology agnostic

Participate in definition of standardsPublish standardsDrive adoption

Identify provider(s)Assess compliance of solutions/servicesProvide ‘label’ for compliant solutions/services

Provide forum for discussionSurface/present opportunities for collaboration

Understand requirements (possibly participate in generation)

Participate in definition of standardsAdopt standards

Offers compliant solutions/services that meet requirements Maintain/operate

Assess feasibility of transactional services provision

Easy plug & play (integration)Lower cost of operationMore functionality

Mission accomplished

Creates new Business Opportunities

Pro

vid

er

Bro

ke rB

uyer

• Pistoia Alliance• Chair: TBD• Steering Committee: all participants investing in the

project (money, resources, time).• Low level funding, time/input from members will be

critical.• Will seek the wide involvement from Pistoia Alliance

members as this potentially has benefits for all participants.

Expected Benefits (Value)

Opportunities / ThreatsSuccess Criteria

Stakeholders & Resource Requirements

Background

• Development of a project team of interested parties.

• All parties agreed of major outcome is a document that includes:

• Use Cases• Process Descriptions• IP and data ownership policy

recommendations• Import / Export licencing

regulations• Agreed areas of focus limited to chemical

synthesis in the first instance.• All parties prepared to submit exemplar use

cases for documentation.• All parties to review existing ‘standards’ and

make recommendations on their use within this initiative

• Review value, cost, technical feasibility and minimum core standard process required to move to service specification development.

• Documentation of standard processes to increase speed of information and material transfer between externalization partners.

• Improved visibility and usability of shared information and data.

• Reduced externalization initiation costs and minimal impact on externalization partner’s infrastructure.

• Potential future service development could result in significant savings in the cost of chemistry externalization.

• To create documented use cases and process descriptions that could form the basis of a service specification that supports the externalizing of chemistry synthesis business processes.

• Specifically:• Common use cases for compound ordering,

identification of reagents, compound ordering and shipping of materials to and from the externalization partner.

• Process descriptions for the transfer of chemical and experimental information to and from the externalization partner

• At least 3 pharma , 1 or more contract research company (CRO); and other service participants .

• Agreed use case and standard processes document generated by end Q4 2011.

• Clear picture of feasibility from all stakeholders and >66% of partners interested in developing a service standard for Chemistry Externalization.

• Synthetic chemistry is increasing being externalized to remote geographies by large pharmaceutical companies looking to reduce costs.

• The lack of well defined standard processes between externalization partners can result in delays in the necessary information and materials transfers across the interfaces in the shared workflow.

• Collaboration between chemists in the respective partners could be improved by greater visibility of key information & knowledge transfer at critical stages on the synthetic process.

• A less than optimal exchange of physical assets during the process can lead to inefficiency that may impact on the quality of the final product and the speed of shipping it to customers.

Business Challenge Project Objectives

Q2 11 Q4 11Q3 11Mar 11 Q1 12

M

M

Board Approval

Pilot Planning & Recruitment

Pilot Kick-off Resourcing

Execution

Key Milestones (Draft Exampel only)

Activities / Deliverables

Chemistry Externalization Processes Charter

• Pistoia Alliance sponsored project.• Enabling activity to support key aspects on the

Pistoia Alliance Chemistry strategy.

Background

V1.1 March 2011

• Simplification of synthetic business process externalization.

• Clarity of data ownership paramount in line with legal strictures of collaboration agreements.

• Lack of CRO participation would affect perceived value of deliverables.

Next Phase

Discussion

• The Two ideas presented are to be taken into a round of funding with members.

• There is no shortage of ideas.• Do these ideas resonate?• Are there other Chemistry enablers

that you see as more important?

Questions

?