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Polysaccharides
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Polysaccharides

Kishan Gopal RamawatJean-Michel MerillonEditors

Polysaccharides

Bioactivity and Biotechnology

With 488 Figures and 154 Tables

EditorsKishan Gopal RamawatBotany DepartmentM.L. Sukhadia UniversityUdaipur, India

Jean-Michel MerillonGroupe d’Etude des Substances Vegetales àActivite BiologiqueUniversite de Bordeaux, Institut desSciences de la Vigne et du VinVillenave d’Ornon, France

ISBN 978-3-319-16297-3 ISBN 978-3-319-16298-0 (eBook)ISBN 978-3-319-16299-7 (print and electronic bundle)DOI 10.1007/978-3-319-16298-0

Library of Congress Control Number: 2015941889

Springer Cham Heidelberg New York Dordrecht London# Springer International Publishing Switzerland 2015This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part ofthe material is concerned, specifically the rights of translation, reprinting, reuse of illustrations,recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission orinformation storage and retrieval, electronic adaptation, computer software, or by similar or dissimilarmethodology now known or hereafter developed.The use of general descriptive names, registered names, trademarks, service marks, etc. in thispublication does not imply, even in the absence of a specific statement, that such names are exemptfrom the relevant protective laws and regulations and therefore free for general use.The publisher, the authors and the editors are safe to assume that the advice and information in this bookare believed to be true and accurate at the date of publication. Neither the publisher nor the authors or theeditors give a warranty, express or implied, with respect to the material contained herein or for any errorsor omissions that may have been made.

Printed on acid-free paper

Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

Preface

We are pleased to present a three volume treatise on “Polysaccharides: Bioactivity

and Biotechnology.” Polysaccharides are present throughout the plant kingdom and

involved in various biological processes including defense for the plant and many

useful applications for human welfare.

This work on polysaccharides is a reference work providing state-of-the-art

knowledge composed by highly renowned scientists in their field. The book aims

to present comprehensive, up-to-date, and well-established information about com-

plex and astonishing structures, properties, and biotechnological applications of

polysaccharides and their upcoming industrial applications. The book will be a

valuable source on polysaccharides to those working in the field of industrial

production and biotechnology development. Polysaccharides are a class of impor-

tant biomacromolecules, with complex structures and various functional activities.

Polysaccharides are extremely common and wide-spread in nature, with cellulose

as the most common and abundant organic compound on the planet. It is believed

that the second most common polysaccharide in the world after cellulose is chitin.

Chitin is to shellfish what cellulose is to trees. This is a very timely compilation of

recent developments about polysaccharides as no book is available in this format.

These polysaccharides find many uses: cf. for example the significant role of

cellulose in the paper and textile industries, as a feedstock for the production of

rayon (via the viscose process), cellulose acetate, celluloid, and nitrocellulose; as

surgical threads (chitin), as sources of energy, dietary fibers, as a blood flow

adjuvant; cosmetics, emulsion stabilizer, film former, binder, viscosity increasing

agent, and skin conditioning agent; direct food additives in gums and chewing gum

bases; and as vaccines. Many polysaccharides have been developed into useful

products, including xanthan gum, dextran, welan gum, gellan gum, diutan gum, and

pullulan.

This comprehensive and thoroughly up-to-date reference book presents the

sources, identification, methods of analysis, biosynthesis, biotechnology, and appli-

cations of important polysaccharides likes starches, cellulose, chitin, gum, and

microbial polysaccharides. Polysaccharides have received much attention recently

because of the emergence of different biological activities, such as immunomodu-

latory, antibacterial, antimutagenic, radioprotective, anti-oxidative, anti-ulcer,

antidepressant, antisepticemic, anticancer, and anti-inflammatory activities.

v

New industrial applications in pharmaceutical and medical sciences are being

developed. Due to these properties and benefits, a vast body of data is being

generated.

The various polysaccharides constitute important classes of biological polymers,

which are dealt with in these volumes. The handbook is divided in several sections

to encompass the entire spectrum of developments in this field: Part I. Biology and

Biotechnology: occurrence, structure, distribution and biotechnology (bacterial

polysaccharides, fungal polysaccharides, polysaccharides from lower plants, poly-

saccharides from higher plants including gums), biosynthesis of polysaccharides,

applications in biotechnology, production by fermentation, biopolymers from

marine prokaryotes, carrageenan, dextrans, polysaccharide nanocrystals, and mod-

ified gums in drug delivery. Part II. Food: structural (pectins, cellulose, xylans,

gum, gumexudates, glycosamines), storage (starch, glycogens, fructans, minor

polysaccharides), marine polysaccharides (alginate and brown sea weeds, carra-

geenan, and red sea weeds; agar, agarose, chitosan, and chitin derivatives), bacterial

and synthetic polysaccharides (dextrans, cyclodextrins, gellans, xanthan, pullulan,

etc.), polysaccharides from edible plant parts, and as functional foods. Part III.

Methods: Extraction, identification, quantification, assays, and emerging technolo-

gies. Part IV. Bioactivity: applications in medicine, immunostimulant, polysaccha-

rides from algal, aloe, brown seaweeds, fructus, ganoderma, medicinal mushrooms,

scleroderma, and their biological activity. Most of the chapters are well illustrated,

many of them in color, for the benefit of the readers. A comprehensive index section

will assist in navigating through this book when searching for specific topics.

Well recognized international specialists in their respective fields of research

have contributed these chapters. This book will be useful to everybody working in

the field of botany, phytochemistry, pharmacy, drug delivery, molecular biology,

forestry, biotechnology, and industrial/food and medical products. This work is

arranged in 73 well illustrated chapters.

Because of the voluminous work for the treatise, this project was spread over

almost 2 years, from concept to print. We would like to acknowledge cooperation,

patience, and support of our contributors who have put their serious efforts to

ensure the high scientific quality of this book with up-to-date information.

This work could not have been completed without active support of Springer

team who took pains in streamlining the production process. We are particularly

indebted to Drs. Tobias Wassermann, Sylvia Blago, and Stephanie H€ugler for theircontinuous support from the very inception of the project. Our final and most

heartfelt thanks we want to give to our wives Marie-Claude Merillon and Manju

Ramawat, who have supported us during the entire period of this book project.

March 2015 J. M. Merillon

K. G. Ramawat

vi Preface

Contents

Volume 1

Part I Biology and Biotechnology . . . . . . . . . . . . . . . . . . . . . . . . . . . 1

1 Plant Cell Wall Polysaccharides: Structure and Biosynthesis . . . . 3

Michael A. Held, Nan Jiang, Debarati Basu, Allan M. Showalter, and

Ahmed Faik

2 Cell Wall Evolution and Diversity . . . . . . . . . . . . . . . . . . . . . . . . . 55

David S. Domozych

3 Bacterial Polysaccharides: An Overview . . . . . . . . . . . . . . . . . . . . 81

Swati Misra, Varsha Sharma, and Ashok Kumar Srivastava

4 Algal Polysaccharides and Health . . . . . . . . . . . . . . . . . . . . . . . . . 109

Ladislava Misurcová, Jana Orsavová, and Jarmila Vávra Ambrozová

5 Polysaccharides from Lower Plants: Bryophytes . . . . . . . . . . . . . 145

Laura Klavina

6 Microbial Production of Extracellular Polysaccharides from

Biomass Sources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161

Emrah Ozcan and Ebru Toksoy Oner

7 Tree Gum: Gum Kondagogu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185

Rao Beedu Sashidhar, D. Raju, and Rasineni Karuna

8 Chitosan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219

Surinder P. Chawla, Sweetie R. Kanatt, and A. K. Sharma

9 Cyclodextrins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247

Andre Sá Couto, Paulo Salustio, and Helena Cabral-Marques

10 Cellulosic Biomaterials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289

Holger Wondraczek and Thomas Heinze

vii

11 Starch Metabolism in Green Plants . . . . . . . . . . . . . . . . . . . . . . . . 329

Maria V. Busi, Diego F. Gomez-Casati, Mariana Martın,

Julieta Barchiesi, Mauricio J. Grisolıa, Nicolás Hedın, andJulieta B. Carrillo

12 Fungal Cultivation and Production of Polysaccharides . . . . . . . . . 377Carla Maısa Camelini, Márcio Jose Rossi, Francielle T. G. S.

Cardozo, A. Gomes, Ceci Sales-Campos, and Admir J. Giachini

13 Starch and Nanoparticle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 417Alain Dufresne

14 Polysaccharide Production by Submerged Fermentation . . . . . . . 451Oscar J. Sánchez, Sandra Montoya, and Liliana M. Vargas

15 Cellulose from Lignocellulosic Waste . . . . . . . . . . . . . . . . . . . . . . . 475Michele Michelin, Hector A. Ruiz, Daniel P. Silva, Denise S. Ruzene,

Jose A. Teixeira, and Maria Lourdes T. M. Polizeli

16 Sugarcane Straw and Its Cellulosic Fraction as Raw Materials

for Obtainment of Textile Fibers and Other Bioproducts . . . . . . . 513Sirlene M. Costa, Andre Aguiar, Sandra M. Luz,

Adalberto Pessoa, and Silgia A. Costa

17 Endogenous Hydrolyzing Enzymes: Isolation, Characterization,

and Applications in Biological Processes . . . . . . . . . . . . . . . . . . . . 535Waleed Ahmad Khattak, Mazhar Ul-Islam,

Muhammad Wajid Ullah, Shaukat Khan, and Joong Kon Park

18 Production of Pullulan by Microbial Fermentation . . . . . . . . . . . 581

Venkatachalam Ponnusami and Varadarajan Gunasekar

19 Biosynthesis of Extracellular Matrix Components,

Glycosaminoglycans, Proteoglycans, Collagens, Elastin and

Structural Glycoproteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 597

Leslie Robert

20 Polysaccharides from Bioagro-Waste for New Biomolecules . . . . 603

Paola Di Donato, Annarita Poli, Valentina Taurisano, and

Barbara Nicolaus

Volume 2

Part II Food . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 639

21 Gum of Prosopis/Acacia Species . . . . . . . . . . . . . . . . . . . . . . . . . . . 641

Yolanda L. Lopez-Franco, Francisco M. Gooycolea, and

Jaime Lizardi-Mendoza

22 Resistant Starch in Food Industry . . . . . . . . . . . . . . . . . . . . . . . . . 663

Leyla Khalili and Amir Amini

viii Contents

23 Inulin and Health Benefits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 675

Matthias Moser, Anke Sentko, and Helene Alexiou

24 Active Edible and Biodegradable Starch Films . . . . . . . . . . . . . . . 717Laura Sánchez-González, Elmira Arab-Tehrany, Maite Cháfer,Chelo González-Martınez, and Amparo Chiralt

25 Dextran and Food Application . . . . . . . . . . . . . . . . . . . . . . . . . . . . 735Damini Kothari, Deeplina Das, Seema Patel, and Arun Goyal

26 Galactans and Its Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . 753Guillaume Pierre, Cedric Delattre, Celine Laroche, and Philippe Michaud

27 Functional Components in Zizyphus with Emphasis onPolysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 795

Tsai Hua Kao and Bing Huei Chen

28 Chitosan-Based Edible Films . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 829

Maher Z. Elsabee

29 Characterization of Psyllium (Plantago ovata) Polysaccharideand Its Uses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 871

Ashwini R. Madgulkar, Monica R. P. Rao, and Deepa Warrier

30 Dietary Fiber and Prebiotics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 891

Werner Praznik, Renate Loeppert, Helmut Viernstein,

Alexander G. Haslberger, and Frank M. Unger

31 Polysaccharide-Protein Complexes from Edible Fungi and

Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 927

Jian-Yong Wu

32 Oligosaccharides from Botrytis cinerea and Elicitation of

Grapevine Defense . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 939

Cassandrine Saigne-Soulard, Assia Abdelli-Belhadj, Marie

Telef-Micouleau, Jerome Bouscaut, Stephanie Cluzet,

Marie-France Corio-Costet, and Jean-Michel Merillon

33 Physical Properties of Inulin and Technological Applications . . . 959

Cesar Leyva-Porras, Ana L. Lopez-Pablos, Claudia Alvarez-Salas,

Jose Perez-Urizar, and Zenaida Saavedra-Leos

Part III Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 985

34 Microwave-Assisted Extraction of Polysaccharides . . . . . . . . . . . . 987

Ana Cristina Soria, Laura Ruiz-Aceituno, Lourdes Ramos, and

Luz Maria Sanz

35 Preparation and Characterization of Polysaccharides from

Mushrooms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1009

Fengmei Zhu, Bin Du, and Baojun Xu

Contents ix

36 Isolation, Purification, and Nanotechnological Applications of

Chitosan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1029

Joydeep Dutta

37 Enzyme-Assisted Extraction of a Marine Algal Polysaccharide,

Fucoidan and Bioactivities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1065

H. H. Chaminda Lakmal, Ji-Hyeok Lee, and You-Jin Jeon

38 Microwave-Synthesized Polysaccharide Copolymers . . . . . . . . . . 1079

Marcin Łukasiewicz, Grzegorz Kowalski, and Anna Ptaszek

39 Analytical Methods for Lignocellulosic Biomass StructuralPolysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1121

Jason S. Lupoi

40 Carbohydrate Secondary and Tertiary Structure Using Raman

Spectroscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1181

Shaun Thomas Mutter and Ewan William Blanch

41 Production, Upgrading and Analysis of Bio-oils Derived from

Lignocellulosic Biomass . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1219

Pankaj K. Kanaujia

42 HPLC Method for Microanalysis and Pharmacokinetics of

Marine Sulfated Polysaccharides, Propylene Glycol Alginate

Sodium Sulfate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1251

Yi-Ting Xue, Chun-Xia Li, Xia Zhao, and Hua-Shi Guan

43 Determination of Must and Wine Polysaccharides by Gas

Chromatography-Mass Spectrometry (GC-MS) and

Size-Exclusion Chromatography (SEC) . . . . . . . . . . . . . . . . . . . . . 1265

Zenaida Guadalupe, Belen Ayestarán, Pascale Williams, and

Thierry Doco

44 NMR Spectroscopy for the Determination of Mucoadhesive

Properties of Polysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1299

Gloria Uccello-Barretta, Federica Balzano, and Federica Aiello

45 Transition-Metal-Catalyzed Transformation of Monosaccharides

and Polysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1319

Zuzana Hricovıniová

46 Surface Properties of Polysaccharides . . . . . . . . . . . . . . . . . . . . . . 1373

Yi Wang and Gary A. Dykes

47 Computerized Models of Carbohydrates . . . . . . . . . . . . . . . . . . . . 1397

Alfred D. French

48 Carbohydrate Microarrays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1441

Denong Wang, Jin Tang, Russell D. Wolfinger, and

Gregory T. Carroll

x Contents

49 Advanced Nano-biocomposites Based on Starch . . . . . . . . . . . . . . 1467

Fengwei Xie, Eric Pollet, Peter J. Halley, and Luc Averous

50 Chemically Modified Natural Polysaccharides to Form Gels . . . . 1555

John Garner and Kinam Park

Volume 3

Part IV Bioactivity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1583

51 Extraction, Structure, and Bioactivities of the Polysaccharides

from Fructus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1585

Yanfang Wu, Xinsheng Wang, and Enguo Fan

52 Bioactivity of Chitosan Derivatives . . . . . . . . . . . . . . . . . . . . . . . . 1609

Mani Prabaharan

53 Gellan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1627

Ding Kang, Hong-Bin Zhang, Yoko Nitta, Ya-Peng Fang, and

Katsuyoshi Nishinari

54 Bioactivity and Applications of Polysaccharides from

Marine Microalgae . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1683

Maria Filomena de Jesus Raposo, Alcina Maria Miranda Bernardo

de Morais, and Rui Manuel Santos Costa de Morais

55 Pectic Polysaccharides and Their Functional Properties . . . . . . . 1729

Beda M. Yapo and Dago Gnakri

56 Recent Advances on the Development of Antibacterial

Polysaccharide-Based Materials . . . . . . . . . . . . . . . . . . . . . . . . . . . 1751

Veronique Coma, Carmen S. R. Freire, and Armando J. D. Silvestre

57 Modified Polysaccharides for Drug Delivery . . . . . . . . . . . . . . . . . 1805

Eleni K. Efthimiadou, Aikaterini-Foteini Metaxa, and George Kordas

58 Chitosan-Based Polysaccharide Biomaterials . . . . . . . . . . . . . . . . 1837

Jayachandran Venkatesan, Baboucarr Lowe, Ramjee Pallela, and

Se-Kwon Kim

59 Structure and Bioactivities of Fungal Polysaccharides . . . . . . . . . 1851

Muhammad Saeed Khan, Xuewu Zhang, Lijun You, Xiong Fu, and

Arshad Mehmood Abbasi

60 Biopolysaccharides for Skin Hydrating Cosmetics . . . . . . . . . . . . 1867

Mayuree Kanlayavattanakul and Nattaya Lourith

61 Polysaccharides from Medicinal Mushrooms and Their

Antitumor Activities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1893

Haixia Chen and Shuqin Li

Contents xi

62 Resistant Starch as Functional Ingredient . . . . . . . . . . . . . . . . . . . 1911

Elena Sánchez-Zapata, Manuel Viuda-Martos,

Juana Fernández-Lopez, and Jose A. Perez-Alvarez

63 Pharmaceutical Applications of Various Natural Gums . . . . . . . . 1933

Anand Shankar Deshmukh and Tejraj M. Aminabhavi

64 Cationic Polymers for the Delivery of Therapeutic

Nucleotides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1969

Anjali Jain, Hossein Hosseinkhani, Abraham J. Domb, and

Wahid Khan

65 Dietary Polysaccharides and Immune Modulation . . . . . . . . . . . . 1991

Herta Stutz Dalla Santa, Pedro Roosevelt Torres Romao,

Vanessa Sovrani, Fabio Rodrigues Oliveira, Alessandra Peres, and

Marta Chagas Monteiro

66 Bacterial Polysaccharides: Production and Applications in

Cosmetic Industry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2017

Filomena Freitas, Vıtor D. Alves, and Maria A. M. Reis

67 Effects of Polysaccharide-Based Formulations on

Human Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2045

Patrıcia Maria Berardo Goncalves Maia Campos,

Maisa Oliveira de Melo, and Flavio Bueno de Camargo Junior

68 Major Advances in the Development of Synthetic

Oligosaccharide-Based Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . 2065

Damiano Cancogni, Matteo Fusari, Niccolo Poggi, and Luigi Lay

69 Plant Polysaccharides and Their Effects on Cell Adhesion . . . . . . 2117

Xianxiang Xu

70 Polysaccharides from Aloe vera and Oral Ulcerations . . . . . . . . . 2137

Kanokporn Bhalang and Kevin Tompkins

71 Natural Polysaccharides from Mushrooms: Antinociceptive

and Anti-inflammatory Properties . . . . . . . . . . . . . . . . . . . . . . . . . 2151

Fhernanda Ribeiro Smiderle, Andrea Caroline Ruthes, and Marcello

Iacomini

72 Polysaccharides in Cancer Prevention: From Bench to

Bedside . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2179

Sanjeev Banerjee, Mansi Parasramka, and Shivani B. Paruthy

73 Polysaccharides from the Fungus Scleroderma . . . . . . . . . . . . . . . 2215

Marılia da Silva Nascimento Santos and Edda Lisboa Leite

Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2233

xii Contents

About the Editors

Professor Dr. Kishan G. Ramawat is Former Pro-

fessor and Head of the Botany Department,

M.L. Sukhadia University, Udaipur, India, and can

look back on longstanding research experience.

He received his Ph.D. in Plant Biotechnology in

1978 from the University of Jodhpur, India, and after-

wards joined the university as a faculty member.

In 1991 he moved to the M.L. Sukhadia University

in Udaipur as Associate Professor and became

Professor in 2001. He served as the Head of the

Department of Botany (2001–2004, 2010–2012),

was in charge of the Department of Biotechnology

(2003–2004), was a member of the task force on medicinal and aromatic plants of

the Department of Biotechnology, Government of India, New Delhi (2002–2005),

and coordinated UGC-DRS and DST-FIST programs (2002–2012).

Professor Ramawat had done his postdoctoral studies at the University of Tours,

France, from 1983 to 1985, and later returned to Tours as visiting professor (1991).

He also visited the University of Bordeaux 2, France, several times as visiting

professor (1995, 1999, 2003, 2006, 2010), and in 2005 Poland in an academic

exchange program (2005). Through these visits in France, Prof. Ramawat and Prof.

Merillon established a strong connection, which has resulted in productive collab-

orations and several book and reference work publications.

Professor Ramawat has published more than 170 well-cited peer-reviewed

papers and articles, and edited several books and reference works on topics such

as the biotechnology of medicinal plants, secondary metabolites, bioactive mole-

cules, herbal drugs, and many other topics. His research was funded by several

funding agencies.

In his research group, Prof. Ramawat has supervised doctoral thesis of

25 students. He is an active member of several academic bodies, associations,

and editorial boards of journals.

xiii

Professeur Dr. Jean-Michel Merillon Directeur de

l’EA 3675/Faculte de Pharmacie/Universite de

Bordeaux is the “Directeur de l’EA 3675 (Groupe

d’Etude des Substances Vegetales à Activite

Biologique + Polyphenols Biotech)” at the Faculte

de Pharmacie, Universite de Bordeaux, Institut des

Sciences de la Vigne et du Vin, in Villenave d’Ornon,

France. He received his M.Pharma. (1979) and Ph.D.

(1984) from the University of Tours in France.

He joined the University of Tours as assistant

professor in 1981, and became associate professor in

1987. In 1993 he moved to the faculty of Pharmacy,

University of Bordeaux, France, accepting a position as full professor. He is

currently leading the “study group on biologically active plant substances” at the

Institute of Vine and Wine Sciences, which comprises 25 scientists and research

students. The group has been working on phenolic compounds from vine and wine

for many years, mainly complex stilbenes and their involvement in health. Profes-

sor Merillon has supervised the doctoral theses of 19 students. He is involved in

developing teaching on plant biology, natural bioactive compounds, and

biotechnology.

Professor Merillon has published more than 145 research papers in internation-

ally recognized journals, resulting in an H index of 35 (documents published

between 1996 and 2015). He has co-edited books and reference works on secondary

metabolites and biotechnology.

Throughout his career, Prof. Merillon has traveled widely as a senior professor.

Scientists from several countries have been and are working in his laboratory, and

his research is supported by funding from the Aquitaine Regional Government,

the Ministry of Higher Education and Research, and various private companies.

In 2004, he founded the technology transfer unit “Polyphenols Biotech,” providing

support for R&D programs for SMEs and major groups from the cosmetic,

pharmaceutical, agricultural, and health-nutrition sectors.

xiv About the Editors

Contributors

Arshad Mehmood Abbasi College of Light Industry and Food Sciences, South

China University of Technology, Guangzhou, China

Department of Environmental Sciences, COMSATS Institute of Information Tech-

nology, Abbottabad, Pakistan

Assia Abdelli-Belhadj Groupe d’Etude des Substances Vegetales à Activite

Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite de

Bordeaux, Villenave d’Ornon, France

Andre Aguiar Institute of Natural Resources, Federal University of Itajubá,Itajubá, Brazil

Federica Aiello Department of Chemistry and Industrial Chemistry, University of

Pisa, Pisa, Italy

Helene Alexiou BENEO Institute, Mannheim, Germany

Claudia Alvarez-Salas Facultad de Ingenierıa, Universidad Autonoma de San

Luis Potosı, San Luis Potosı, SLP, Mexico

Vıtor D. Alves CEER-Biosystems Engineering, Instituto Superior de Agronomia,

Universidade de Lisboa, Lisbon, Portugal

Jarmila Vávra Ambrozová Department of Food Analysis and Chemistry, Faculty

of Technology, Tomas Bata University in Zlın, Zlın, Czech Republic

Tejraj M. Aminabhavi Department of Pharmaceutical Engineering, S.E.T’s

College of Pharmacy, Dharwad, Karnataka, India

Amir Amini Department of Food Science and Technology, Faculty of Nutrition,

Tabriz University of Medical Sciences, Tabriz, Iran

Elmira Arab-Tehrany Universite de Lorraine, LIBio, ENSAIA, Vandœuvre-les-

Nancy, France

Luc Averous BioTeam/ICPEES-ECPM, UMR 7515, Universite de Strasbourg,

Strasbourg, France

Belen Ayestarán Instituto de Ciencias de la Vid y del Vino, Universidad de la

Rioja, Gobierno de La Rioja y CSIC, Logrono, Spain

xv

Federica Balzano Department of Chemistry and Industrial Chemistry, University

of Pisa, Pisa, Italy

Sanjeev Banerjee Department of Pathology, Barbara Ann Karmanos Cancer

Institute, Detroit, MI, USA

School of Medicine, Wayne State University, Detroit, MI, USA

Julieta Barchiesi Molecular Biology and Plant Biotechnology Laboratory, Centro

de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad

Nacional de Rosario, Rosario, Argentina

Debarati Basu Department of Environmental and Plant Biology, Molecular and

Cellular Biology Program, Ohio University, Athens, OH, USA

Kanokporn Bhalang Faculty of Dentistry, Chulalongkorn University, Bangkok,

Thailand

Ewan William Blanch School of Applied Sciences, RMIT University, Melbourne,

VIC, Australia

Jerome Bouscaut INRA, Institut des Sciences de la Vigne et du Vin (ISVV),

UMR Sante et Agroecologie du Vignoble (1065), Villenave d’Ornon, France

Maria V. Busi Molecular Biology and Plant Biotechnology Laboratory, Centro

de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad

Nacional de Rosario, Rosario, Argentina

Helena Cabral-Marques Instituto de Investigacao do Medicamento, Faculdade

de Farmácia, Universidade de Lisboa, Lisboa, Portugal

Carla Maısa Camelini Laboratorio de Cultivo de Fungos Comestıveis, Instituto

Nacional de Pesquisas da Amazonia, Universidade Federal do Amazonas, Manaus,

Brazil

Damiano Cancogni Department of Chemistry, University of Milan, Milan, Italy

Francielle T. G. S. Cardozo Laboratorio de Virologia, Departamento de

Molestias Infecciosas e Parasitárias, Instituto de Medicina Tropical, Universidade

de Sao Paulo, Sao Paulo, Brazil

Julieta B. Carrillo Molecular Biology and Plant Biotechnology Laboratory,

Centro de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET),

Universidad Nacional de Rosario, Rosario, Argentina

Gregory T. Carroll Sunstar Engineering Americas, Springboro, OH, USA

Maite Cháfer Departamento de Tecnologıa de Alimentos, Instituto de Ingenierıa

de Alimentos para el Desarrollo, Universitat Politecnica de Valencia, Valencia,

Spain

Surinder P. Chawla Food Technology Division, Bhabha Atomic Research

Centre, Mumbai, India

xvi Contributors

Bing Huei Chen Department of Food Science, Fu Jen University, Taipei, Taiwan

Haixia Chen Tianjin Key Laboratory for Modern Drug Delivery and High-

Efficiency, School of Pharmaceutical Science and Technology, Tianjin University,

Tianjin, China

Amparo Chiralt Departamento de Tecnologıa de Alimentos, Instituto de

Ingenierıa de Alimentos para el Desarrollo, Universitat Politecnica de Valencia,

Valencia, Spain

Stephanie Cluzet Groupe d’Etude des Substances Vegetales à Activite

Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite de

Bordeaux, Villenave d’Ornon, France

Veronique Coma University of Bordeaux, CNRS, LCPO, UMR 5629, Pessac,

France

LCPO, ENSCBP, Bordeaux University, Talence, France

Marie-France Corio-Costet INRA, Institut des Sciences de la Vigne et du

Vin (ISVV), UMR Sante et Agroecologie du Vignoble (1065), Villenave

d’Ornon, France

Silgia A. Costa School of Arts, Sciences and Humanities, University of Sao Paulo,

Sao Paulo, Brazil

Sirlene M. Costa School of Arts, Sciences and Humanities, University of Sao

Paulo, Sao Paulo, Brazil

Marılia da Silva Nascimento Santos Laboratory of Glycobiology, Department of

Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil

Deeplina Das Department of Bio-Engineering, National Institute of Technology

Agartala, West Tripura, India

Flavio Bueno de Camargo Junior Pharmaceutical Sciences of Ribeirao Preto,

University of Sao Paulo, Ribeirao Preto, Brazil

Maria Filomena de Jesus Raposo CBQF - Centro de Biotecnologia e Quımica

Fina – Laboratorio Associado, Escola Superior de Biotecnologia, Universidade

Catolica Portuguesa/Porto, Porto, Portugal

Maisa Oliveira deMelo Pharmaceutical Sciences of Ribeirao Preto, University of

Sao Paulo, Ribeirao Preto, Brazil

Alcina Maria Miranda Bernardo de Morais CBQF - Centro de Biotecnologia e

Quımica Fina – Laboratorio Associado, Escola Superior de Biotecnologia,

Universidade Catolica Portuguesa/Porto, Porto, Portugal

Rui Manuel Santos Costa de Morais CBQF - Centro de Biotecnologia e Quımica

Fina – Laboratorio Associado, Escola Superior de Biotecnologia, Universidade

Catolica Portuguesa/Porto, Porto, Portugal

Contributors xvii

Cedric Delattre Institut Pascal UMR CNRS 6602, Clermont Universite,

Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France

Anand Shankar Deshmukh Department of Pharmaceutical Research, Shree

Dhanvantary Pharmacy College, Surat, Gujarat, India

Thierry Doco INRA, Joint Research Unit, Sciences for Enology, Montpellier,

France

Abraham J. Domb School of Pharmacy, Faculty of Medicine, The Hebrew

University of Jerusalem and Jerusalem College of Engineering (JCE), Jerusalem,

Israel

David S. Domozych Department of Biology and Skidmore Microscopy Imaging

Center, Skidmore College, Saratoga Springs, NY, USA

Paola Di Donato CNR-National Research Council of Italy, Institute of Biomo-

lecular Chemistry, Pozzuoli, NA, Italy

Department of Sciences and Technologies, University of Naples Parthenope,

Naples, Italy

Bin Du Hebei Normal University of Science and Technology, Qinhuangdao,

Hebei, China

Alain Dufresne Grenoble Institute of Technology (Grenoble INP) – The Interna-

tional School of Paper, Print Media and Biomaterials (Pagora), Saint Martin

d’Heres, France

Joydeep Dutta Department of Chemistry, Amity School of Applied Sciences,

Amity University Haryana, Gurgaon, Haryana, India

Gary A. Dykes School of Science, Monash University, Bandar Sunway, Selangor,

Malaysia

School of Chemistry, Monash University, Clayton, VIC, Australia

Eleni K. Efthimiadou Sol–gel Laboratory, Institute of Nanoscience and Nano-

technology, Athens, Greece

Maher Z. Elsabee Department of Chemistry, Faculty of Science, Cairo Univer-

sity, Cairo, Egypt

Ahmed Faik Department of Environmental and Plant Biology, Molecular and

Cellular Biology Program, Ohio University, Athens, OH, USA

Enguo Fan Institute of Biochemistry and Molecular Biology, University of

Freiburg, Freiburg, Germany

Ya-Peng Fang Glyn O. Phillips Hydrocolloids Research Centre School of Food

and Pharmaceutical Engineering, Hubei University of Technology Wuchang,

Wuhan, China

xviii Contributors

Juana Fernández-Lopez IPOA Research Group, Agro-Food Technology Depart-

ment, Escuela Politecnica Superior de Orihuela, Miguel Hernández University,

Alicante, Spain

Carmen S. R. Freire CICECO and Department of Chemistry, University of

Aveiro, Aveiro, Portugal

Filomena Freitas REQUIMTE/CQFB, Chemistry Department, Faculdade de

Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal

Alfred D. French Southern Regional Research Center, Agricultural Research

Service, U.S. Department of Agriculture, New Orleans, LA, USA

Xiong Fu College of Light Industry and Food Sciences, South China University of

Technology, Guangzhou, China

Matteo Fusari Department of Chemistry, University of Milan, Milan, Italy

John Garner Akina, Inc., West Lafayette, IN, USA

Admir J. Giachini Laboratorio de Bioprocessos, Departamento de Microbiologia,

Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis,

Brazil

Dago Gnakri Subunit of Pedagogy in Biochemistry and Microbiology, Unit of

Training and Research in Agroforestry, University of Jean Lorougnon GUEDE

(UJLoG), Daloa, Cote d’Ivoire

A. Gomes Laboratorio de Bioprocessos, Departamento de Microbiologia,

Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis,

Brazil

Diego F. Gomez-Casati Molecular Biology and Plant Biotechnology Laboratory,

Centro de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET),

Universidad Nacional de Rosario, Rosario, Argentina

Chelo González-Martınez Departamento de Tecnologıa de Alimentos, Instituto

de Ingenierıa de Alimentos para el Desarrollo, Universitat Politecnica de Valencia,

Valencia, Spain

Francisco M. Gooycolea Institute for Plant Biology and Biotechnology (IBBP),

University of M€unster, M€unster, Germany

Arun Goyal Department of Biotechnology, Indian Institute of Technology

Guwahati, Guwahati, Assam, India

Mauricio J. Grisolıa Molecular Biology and Plant Biotechnology Laboratory,

Centro de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET),

Universidad Nacional de Rosario, Rosario, Argentina

Zenaida Guadalupe Instituto de Ciencias de la Vid y del Vino, Universidad de la

Rioja, Gobierno de La Rioja y CSIC, Logrono, Spain

Contributors xix

Hua-Shi Guan Key Laboratory of Marine Drugs, Ministry of Education, Shan-

dong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of

Medicine and Pharmacy, Ocean University of China, Qingdao, China

Varadarajan Gunasekar School of Chemical and Biotechnology, SASTRA

University, Thanjavur, Tamil Nadu, India

Peter J. Halley Australian Institute for Bioengineering and Nanotechnology,

The University of Queensland, Brisbane, QLD, Australia

Alexander G. Haslberger Department of Nutritional Research, University of

Vienna, Vienna, Austria

Nicolás Hedın Molecular Biology and Plant Biotechnology Laboratory, Centro de

Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad

Nacional de Rosario, Rosario, Argentina

Thomas Heinze Institute for Organic Chemistry and Macromolecular Chemistry,

Center of Excellence for Polysaccharide Research, Friedrich Schiller University of

Jena, Jena, Germany

Michael A. Held Department of Chemistry and Biochemistry, Molecular and

Cellular Biology Program, Ohio University, Athens, OH, USA

Hossein Hosseinkhani Graduate Institute of Biomedical Engineering, National

Taiwan University of Science and Technology (TAIWAN TECH), Taipei, Taiwan

Zuzana Hricovıniová Institute of Chemistry, Center for Glycomics, Slovak

Academy of Sciences, Bratislava, Slovak Republic

Marcello Iacomini Department of Biochemistry and Molecular Biology, Federal

University of Paraná, Curitiba, Brazil

Anjali Jain Department of Pharmaceutics, National Institute of Pharmaceutical

Education and Research (NIPER), Hyderabad, India

You-Jin Jeon Laboratory of Marine Bioresource Technology, School of Marine

Biomedical Sciences, Jeju National University, Jeju, Republic of Korea

Nan Jiang Department of Environmental and Plant Biology, Molecular and

Cellular Biology Program, Ohio University, Athens, OH, USA

Sweetie R. Kanatt Food Technology Division, Bhabha Atomic Research Centre,

Mumbai, India

Pankaj K. Kanaujia Analytical Sciences Division, Mass Spectrometry Area,

Electron Microscopy Area, CSIR-Indian Institute of Petroleum, Dehradun,

Uttarakhand, India

Ding Kang Shanghai Jiao Tong University, Shanghai, China

Mayuree Kanlayavattanakul School of Cosmetic Science, Mae Fah Luang

University, Chiang Rai, Thailand

xx Contributors

Tsai Hua Kao Department of Food Science, Fu Jen University, Taipei, Taiwan

Rasineni Karuna Department of Biochemistry, University College of Science,

Osmania University, Hyderabad, Telangana, India

Leyla Khalili Department of Nutrition, Faculty of Nutrition, Tabriz University of

Medical Sciences, Tabriz, Iran

Muhammad Saeed Khan College of Light Industry and Food Sciences, South

China University of Technology, Guangzhou, China

Shaukat Khan Department of Chemical Engineering, Kyungpook National

University, Daegu, South Korea

Wahid Khan Department of Pharmaceutics, National Institute of Pharmaceutical

Education and Research (NIPER), Hyderabad, India

Waleed Ahmad Khattak Department of Chemical Engineering, Kyungpook

National University, Daegu, South Korea

Se-Kwon Kim Department of Marine-bio Convergence Science and Marine

Bioprocess Research Center, Pukyong National University, Busan, South Korea

Laura Klavina Department of Environmental Science, University of Latvia, Riga,

Latvia

George Kordas Sol–gel Laboratory, Institute of Nanoscience and Nanotechnol-

ogy, Athens, Greece

Damini Kothari Department of Biotechnology, Indian Institute of Technology

Guwahati, Guwahati, Assam, India

Grzegorz Kowalski Department of Engineering and Machinery in Food Industry,

Faculty of Food Technology, Agriculture University in Krakow, Krakow, Poland

H. H. Chaminda Lakmal Department of Marine Life Science, Jeju National

University, Jeju, Republic of Korea

Celine Laroche Institut Pascal UMR CNRS 6602, Clermont Universite,

Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France

Luigi Lay Department of Chemistry, University of Milan, Milan, Italy

Ji-Hyeok Lee Department of Marine Life Science, Jeju National University, Jeju,

Republic of Korea

Edda Lisboa Leite Laboratory of Glycobiology, Department of Biochemistry,

Federal University of Rio Grande do Norte, Natal, Brazil

Cesar Leyva-Porras Centro de Investigacion de Materiales Avanzados (CIMAV-

Unidad Monterrey), Apodaca, Mexico

Contributors xxi

Chun-Xia Li Key Laboratory of Marine Drugs, Ministry of Education, Shandong

Provincial Key Laboratory of Glycoscience and Glycotechnology, School of

Medicine and Pharmacy, Ocean University of China, Qingdao, China

Shuqin Li Tianjin Key Laboratory for Modern Drug Delivery and High-

Efficiency, School of Pharmaceutical Science and Technology, Tianjin University,

Tianjin, China

Jaime Lizardi-Mendoza CTAOA, Biopolymers Group, Research Center for

Food and Development, Centro de Investigacion en Alimentacion y Desarrollo,

A.C. (CIAD), Hermosillo, Sonora, Mexico

Renate Loeppert Department of Pharmaceutical Technology and Biopharmaceutics,

Faculty of Life Sciences, University of Vienna, Vienna, Austria

Yolanda L. Lopez-Franco CTAOA, Biopolymers Group, Research Center for

Food and Development, Centro de Investigacion en Alimentacion y Desarrollo,

A.C. (CIAD), Hermosillo, Sonora, Mexico

Ana L. Lopez-Pablos Coordinacion Academica Region Altiplano, Universidad

Autonoma de San Luis Potosı, Matehuala, Mexico

Nattaya Lourith School of Cosmetic Science, Mae Fah Luang University, Chiang

Rai, Thailand

Baboucarr Lowe Department of Marine-bio Convergence Science and Marine

Bioprocess Research Center, Pukyong National University, Busan, South Korea

Marcin Łukasiewicz Department of Carbohydrate Technology, Faculty of Food

Technology, Agriculture University in Krakow, Krakow, Poland

Jason S. Lupoi Queensland Alliance for Agriculture and Food Innovation,

University of Queensland, St. Lucia, QLD, Australia

Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville,

CA, USA

Sandra M. Luz Department of Energy, University of Brasılia, Gama, Brazil

Ashwini R. Madgulkar Department of Pharmaceutics, AISSMS College of

Pharmacy, Pune, India

Patrıcia Maria Berardo Goncalves Maia Campos Pharmaceutical Sciences of

Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil

Mariana Martın Molecular Biology and Plant Biotechnology Laboratory, Centro

de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad

Nacional de Rosario, Rosario, Argentina

Jean-Michel Merillon Groupe d’Etude des Substances Vegetales à Activite

Biologique, Universite de Bordeaux, Institut des Sciences de la Vigne et du Vin,

Villenave d’Ornon, France

xxii Contributors

Aikaterini-Foteini Metaxa Sol–gel Laboratory, Institute of Nanoscience and

Nanotechnology, Athens, Greece

Philippe Michaud Institut Pascal UMR CNRS 6602, Clermont Universite,

Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France

Michele Michelin Departamento de Biologia, Faculdade de Filosofia, Ciencias e

Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

Swati Misra Department of Biochemical Engineering and Biotechnology, Indian

Institute of Technology – Delhi, Hauz Khas, New Delhi, India

Ladislava Misurcová Department of Food Analysis and Chemistry, Faculty of

Technology, Tomas Bata University in Zlın, Zlın, Czech Republic

Marta Chagas Monteiro Laboratory of Clinical Microbiology and Immunology,

Faculty of Pharmacy, Federal University of Pará (UFPA), Belem, Brazil

Sandra Montoya Bioprocess and Agro-Industry Plant, Institute of Agricultural

Biotechnology, Universidad de Caldas, Manizales, Colombia

Matthias Moser BENEO Institute, Mannheim, Germany

Shaun Thomas Mutter Manchester Institute of Biotechnology and Faculty of

Life Sciences, The University of Manchester, Manchester, UK

Barbara Nicolaus CNR-National Research Council of Italy, Institute of Biomo-

lecular Chemistry, Pozzuoli, NA, Italy

Katsuyoshi Nishinari Glyn O. Phillips Hydrocolloids Research Centre School of

Food and Pharmaceutical Engineering, Hubei University of Technology Wuchang,

Wuhan, China

Yoko Nitta Okayama Prefectural University, Okayama, Japan

Fabio Rodrigues Oliveira Laboratory of Clinical Microbiology and Immunology,

Faculty of Pharmacy, Federal University of Pará (UFPA), Belem, Brazil

Jana Orsavová Language Centre, Faculty of Humanities, Tomas Bata University

in Zlın, Zlın, Czech Republic

Emrah Ozcan Department of Bioengineering, Gebze Institute of Technology,

Gebze, Turkey

Ramjee Pallela Synthetic Biology and Biofuels Group, International Centre for

Genetic Engineering and Biotechnology, New Delhi, India

Mansi Parasramka Division of Cancer Biology,Mayo Clinic, Jacksonville, FL, USA

Joong Kon Park Department of Chemical Engineering, Kyungpook National

University, Daegu, South Korea

Kinam Park Departments of Biomedical Engineering and Pharmaceutics, Weldon

School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA

Contributors xxiii

Shivani B. Paruthy Department of Surgery, VM Medical College and Safdarjung

Hospital, Guru Gobind Singh Indraprastha (GGSIP) University, New Delhi, India

Seema Patel Bioinformatics and Medical Informatics Research Center, San Diego

State University, San Diego, USA

Alessandra Peres Laboratory of Immunology, Department of Basic Health

Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA),

Porto Alegre, Brazil

Jose A. Perez-Alvarez IPOA Research Group, Agro-Food Technology Depart-

ment, Escuela Politecnica Superior de Orihuela, Miguel Hernández University,

Alicante, Spain

Jose Perez-Urizar Facultad de Ciencias Quımicas, Universidad Autonoma de San

Luis Potosı, San Luis Potosı, Mexico

Adalberto Pessoa Department of Biochemical and Pharmaceutical Technology,

University of Sao Paulo, Sao Paulo, Brazil

Guillaume Pierre Institut Pascal UMR CNRS 6602, Clermont Universite,

Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France

Niccolo Poggi Department of Chemistry, University of Milan, Milan, Italy

Annarita Poli CNR-National Research Council of Italy, Institute of Biomolecular

Chemistry, Pozzuoli, NA, Italy

Maria Lourdes T. M. Polizeli Departamento de Biologia, Faculdade de Filosofia,

Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto,

Sao Paulo, Brazil

Eric Pollet BioTeam/ICPEES-ECPM, UMR 7515, Universite de Strasbourg,

Strasbourg, France

Venkatachalam Ponnusami School of Chemical and Biotechnology, SASTRA

University, Thanjavur, Tamil Nadu, India

Mani Prabaharan Department of Chemistry, Hindustan Institute of Technology

and Science, Chennai, Padur, India

Werner Praznik Department of Pharmaceutical Technology and

Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria

Anna Ptaszek Department of Engineering and Machinery in Food Industry,

Faculty of Food Technology, Agriculture University in Krakow, Krakow, Poland

D. Raju Department of Biochemistry, University College of Science, Osmania

University, Hyderabad, Telangana, India

Lourdes Ramos Departamento de Análisis Instrumental y Quımica Ambiental,

Instituto de Quımica Orgánica General (CSIC), Madrid, Spain

xxiv Contributors

Monica R. P. Rao Department of Pharmaceutics, AISSMS College of Pharmacy,

Pune, India

Maria A. M. Reis REQUIMTE/CQFB, Chemistry Department, Faculdade de

Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal

Leslie Robert Laboratoire de Recherches Ophtalmologiques, Faculte de

Medecine Paris Descartes, Hopital Hotel Dieu, Universite Paris-V, Paris, France

Pedro Roosevelt Torres Romao Laboratory of Immunology, Department of

Basic Health Sciences, Federal University of Health Sciences of Porto Alegre

(UFCSPA), Porto Alegre, Brazil

Márcio Jose Rossi Laboratorio de Bioprocessos, Departamento de Microbiologia,

Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis,

Brazil

Hector A. Ruiz Food Research Department, Biorefinery Group, School of

Chemistry, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico

Laura Ruiz-Aceituno Departamento de Análisis Instrumental y Quımica

Ambiental, Instituto de Quımica Orgánica General (CSIC), Madrid, Spain

Andrea Caroline Ruthes Department of Biochemistry and Molecular Biology,

Federal University of Paraná, Curitiba, Brazil

Denise S. Ruzene Center for Exact Sciences and Technology, Federal University

of Sergipe, Aracaju, Brazil

Andre Sá Couto Instituto de Investigacao do Medicamento, Faculdade de

Farmácia, Universidade de Lisboa, Lisboa, Portugal

Zenaida Saavedra-Leos Coordinacion Academica Region Altiplano,

Universidad Autonoma de San Luis Potosı, Matehuala, Mexico

Cassandrine Saigne-Soulard Groupe d’Etude des Substances Vegetales àActivite Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite

de Bordeaux, Villenave d’Ornon, France

Ceci Sales-Campos Laboratorio de Cultivo de Fungos Comestıveis, Instituto

Nacional de Pesquisas da Amazonia, Universidade Federal do Amazonas, Manaus,

Brazil

Paulo Salustio Instituto de Investigacao doMedicamento, Faculdade de Farmácia,Universidade de Lisboa, Lisboa, Portugal

Oscar J. Sánchez Bioprocess and Agro-Industry Plant, Institute of Agricultural

Biotechnology, Universidad de Caldas, Manizales, Colombia

Laura Sánchez-González Laboratoire d’ingenierie des biomolecules (LIBio),

ENSAIA, Universite de Lorraine, Vandœuvre-les-Nancy, France

Elena Sánchez-Zapata Gluten Free Fibers S.L., Elche, Alicante, Spain

Contributors xxv

Luz Maria Sanz Departamento de Análisis Instrumental y Quımica Ambiental,

Instituto de Quımica Orgánica General (CSIC), Madrid, Spain

Rao Beedu Sashidhar Department of Biochemistry, University College of

Science, Osmania University, Hyderabad, Telangana, India

Anke Sentko BENEO Institute, Mannheim, Germany

Department Regulatory Affairs and Nutrition Communication, BENEO GmbH,

Obrigheim, Germany

A. K. Sharma Food Technology Division, Bhabha Atomic Research Centre,

Mumbai, India

Varsha Sharma Department of Biochemical Engineering and Biotechnology,

Indian Institute of Technology – Delhi, Hauz Khas, New Delhi, India

Allan M. Showalter Department of Environmental and Plant Biology, Molecular

and Cellular Biology Program, Ohio University, Athens, OH, USA

Daniel P. Silva Center for Exact Sciences and Technology, Federal University of

Sergipe, Aracaju, Brazil

Armando J. D. Silvestre CICECO and Department of Chemistry, University of

Aveiro, Aveiro, Portugal

Fhernanda Ribeiro Smiderle Department of Biochemistry and Molecular Biol-

ogy, Federal University of Paraná, Curitiba, Brazil

Ana Cristina Soria Departamento de Análisis Instrumental y Quımica Ambiental,

Instituto de Quımica Orgánica General (CSIC), Madrid, Spain

Vanessa Sovrani Department of Biochemistry and Molecular Biology, Life

Sciences - Polytechnic Center Campus, Federal University of Paraná (UFPR),

Curitiba, Brazil

Ashok Kumar Srivastava Department of Biochemical Engineering and Biotech-

nology, Indian Institute of Technology – Delhi, Hauz Khas, New Delhi, India

Herta Stutz Dalla Santa Department of Food Engineering, Midwest State

University-UNICENTRO, Guarapuava, Brazil

Jin Tang Tumor Glycomics Laboratory, Biosciences Division, SRI International,

Menlo Park, CA, USA

Valentina Taurisano CNR-National Research Council of Italy, Institute of

Biomolecular Chemistry, Pozzuoli, NA, Italy

Department of Sciences and Technologies, University of Naples Parthenope,

Naples, Italy

Jose A. Teixeira Center of Biological Engineering, University of Minho, Braga,

Portugal

xxvi Contributors

Marie Telef-Micouleau Groupe d’Etude des Substances Vegetales à Activite

Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite de

Bordeaux, Villenave d’Ornon, France

Ebru Toksoy Oner Department of Bioengineering, Industrial Biotechnology and

Systems Biology (IBSB) Research Group, Marmara University, Istanbul, Turkey

Kevin Tompkins Faculty of Dentistry, Chulalongkorn University, Bangkok,

Thailand

Gloria Uccello-Barretta Department of Chemistry and Industrial Chemistry,

University of Pisa, Pisa, Italy

Mazhar Ul-Islam Department of Chemical Engineering, Kyungpook National

University, Daegu, South Korea

Muhammad Wajid Ullah Department of Chemical Engineering, Kyungpook

National University, Daegu, South Korea

Frank M. Unger Department of Pharmaceutical Technology and

Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria

Liliana M. Vargas Bioprocess and Agro-Industry Plant, Institute of Agricultural

Biotechnology, Universidad de Caldas, Manizales, Colombia

Jayachandran Venkatesan Department of Marine-bio Convergence Science

and Marine Bioprocess Research Center, Pukyong National University, Busan,

South Korea

Helmut Viernstein Department of Pharmaceutical Technology and

Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria

Manuel Viuda-Martos IPOA Research Group, Agro-Food Technology Depart-

ment, Escuela Politecnica Superior de Orihuela, Miguel Hernández University,

Alicante, Spain

Denong Wang Tumor Glycomics Laboratory, Biosciences Division, SRI Interna-

tional, Menlo Park, CA, USA

Xinsheng Wang School of Chemical Engineering and Pharmacy, Henan Univer-

sity of Science and Technology, Luoyang, Henan, China

Pharmaceutical School, Nanjing University of Chinese Medicine, Nanjing, Jiangsu,

China

Yi Wang School of Science, Monash University, Bandar Sunway, Selangor,

Malaysia

Deepa Warrier Department of Pharmaceutics, AISSMS College of Pharmacy,

Pune, India

Pascale Williams INRA, Joint Research Unit, Sciences for Enology, Montpellier,

France

Contributors xxvii

Russell D. Wolfinger SAS Institute Inc., Cary, NC, USA

Holger Wondraczek Institute for Organic Chemistry and Macromolecular

Chemistry, Center of Excellence for Polysaccharide Research, Friedrich Schiller

University of Jena, Jena, Germany

Jian-Yong Wu State Key Laboratory of Chinese Medicine and Molecular Phar-

macology in Shenzhen, Department of Applied Biology and Chemical Technology,

The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

Yanfang Wu Pharmaceutical School, Xinxiang Medical University, Xinxiang,

Henan, China

Fengwei Xie Australian Institute for Bioengineering and Nanotechnology,

The University of Queensland, Brisbane, QLD, Australia

Baojun Xu Food Science and Technology Program, United International College,

Beijing Normal University - Hong Kong Baptist University, Zhuhai, Guangdong,

China

Xianxiang Xu Department of Pharmacology, School of Biomedical Science,

Huaqiao University, Quanzhou City, Fujian Province, China

Yi-Ting Xue Key Laboratory of Marine Drugs, Ministry of Education, Shandong

Provincial Key Laboratory of Glycoscience and Glycotechnology, School of

Medicine and Pharmacy, Ocean University of China, Qingdao, China

Beda M. Yapo Subunit of Pedagogy in Biochemistry and Microbiology, Unit of

Training and Research in Agroforestry, University of Jean Lorougnon GUEDE

(UJLoG), Daloa, Cote d’Ivoire

Lijun You College of Light Industry and Food Sciences, South China University

of Technology, Guangzhou, China

Hong-Bin Zhang Shanghai Jiao Tong University, Shanghai, China

Xuewu Zhang College of Light Industry and Food Sciences, South China

University of Technology, Guangzhou, China

Xia Zhao Key Laboratory of Marine Drugs, Ministry of Education, Shandong

Provincial Key Laboratory of Glycoscience and Glycotechnology, School of

Medicine and Pharmacy, Ocean University of China, Qingdao, China

Fengmei Zhu Hebei Normal University of Science and Technology,

Qinhuangdao, Hebei, China

xxviii Contributors


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