POULTRY PRODUCTION SOLUTIONSConsistent Solutions for Ever Changing Production Demands
BACKGROUND
The Veterinary Feed Directive brought a wave of regulatory change
across animal agriculture influencing producers, nutritionists and
veterinarians to generate new strategies for antibiotic use. Additional
pressure on antibiotic use in meat production is being driven by retailer
and consumer demands with many companies already expanding the
amount of antibiotic-free product offerings. Although controversial, the
new paradigm of antibiotic use and push toward antibiotic-free (ABF)
production requires cooperation across all aspects of poultry production
to be successful. In 2016, Novus launched Project Horizon, an
initiative to help producers reduce the need for antibiotics in their
production systems. Project Horizon is an opportunity for Novus to
work in partnership with producers to optimize health through nutrition,
minimizing the need for antibiotic use. By addressing the nutritional
needs for health, both prevention and response to health challenge,
reliance on antibiotics can be reduced.
Designed to provide access to Novus’s expertise in gut health, nutrition
and management strategies, Project Horizon has a dedicated team
of resources and people available. Novus’s wide portfolio of solutions
helps optimize performance and improve animal health, animal well-
being, and profitability.
POULTRY PRODUCTION CHALLENGES AND SOLUTIONS
PATHOGEN EXPOSURE
NATURAL DEFENSES
MODULATE IMMUNE RESPONSE
INCREASED PATHOGEN LOAD WITHOUT ANTIBIOTIC TREATMENT
SOLUTION: DECREASE PATHOGEN LOAD
Physiological and environmental stress can alter intestinal gut flora, resulting in increased opportunity for pathogenic bacterial overgrowth leading to disease and poor performance. To encourage the predominance of beneficial bacteria, feed supplementation with high quality ingredients is essential in order to promote a healthy gastrointestinal tract to combat stressors. Enzymes, organic acids and probiotics have been proven to lower the levels of pathogenic bacteria in poultry, decreasing mortality and condemnations while improving live performance and profitability.
Enzymes aid in supporting a healthy digestive system and reducing nitrogen excretion levels. CIBENZA® DP100 protease shows a reduction in levels of C. perfringens and an improvement in intestinal villi strength through a reduction in systemic inflammation (Figures 1, 2). Protease enzymes also aid in digestion by breaking down non-digestible proteins, which reduces digesta viscosity, optimizing energy and efficiency while minimizing feed cost.
Organic acids are another strategy for fighting against C. perfringens and other pathogens. Research indicates ACTIVATE® WD decreases lesion scores and mortality rates in birds infected with necrotic enteritis (NE) by minimizing the impact and colonization of foodborne pathogens after establishing stable gut microflora (Figures 3, 4). ACTIVATE WD has also been proven to decrease the total percentage of Salmonella in the ceca improving overall gut health.
Nonmedicated
ACTIVATE WD 0.04%
ACTIVATE WD 0.08%
Salmonella Positive (%)
FIGURE 4. Less NE Lesion Scores in the Gut of Broilers, Challenged with Coccidia spp. and C. perfringens, After Supplying ACTIVATE WD MAX
FIGURE 3. Total Percentage of Ceca Salmonella Positive at 49 Days of Age
Lesi
on
Sco
res
at
D
ay
21
P<0.051.0
0.5
0.0Positive Control ACTIVATE WD MAX0 2010 30 5040
FIGURE 1. C. perfinges Counts in the lleum at 15 Days of Age
5.0
4.0
3.0
2.0
1.0
0.0Control High ProteinC
lost
rid
ium
pe
rfri
ng
en
s (l
og
cfu
)
With ProteaseWithout ProteaseYan et al., 2011
With ProteaseWithout Protease
FIGURE 2. CIBENZA DP100 Improves the Crypt:Villus After 14 Days of Age
0.20
0.16
0.12
0.08
0.04
0.00Control High Protein
Valu
e C
ryp
t:V
illu
s
Yan et al., 2011
Dibner et al., 2002Mead et al., 1999
When gut health is optimized, energy usage is targeted to gaining weight and increasing feed conversion. ACTIVATE® WD and MINTREX® chelated trace minerals work together to give birds an advantage in feed conversion as well as gain when suppressed by infection (Figure 8; Table 1).
Probiotics can be added to feed in order to beneficially alter and maintain a bird’s gut microflora for protection against harmful bacteria. SPORULIN®, a three strain direct-fed microbial, targets the production of bacteriocins and competes with pathogens for adhesion sites and nutrients along the GI tract, supporting gut development and health. SPORULIN research shows a decrease in mortality (Figure 5) by reducing the incidence and severity of NE. In addition to reducing the impact of NE on mortality and live performance, SPORULIN has been shown to reduce horizontal transmission of Salmonella (Figure 6) and reduce pathogenic E. coli (Figure 7) in broilers.
FIGURE 6. Horizontal Transmission in Broilers:Percentage of Salmonella Enteriditis Recovery
100
80
60
40
20
0Control Contacts SPORULIN Contacts
Liver/Spleen Ceca
Perc
en
tag
e (
%)
FIGURE 7. Population of E. coli F18 in the Gastrointestinal Tract of Broiler Chicks
CF
U o
f E
. co
li R
esi
stan
t to
N
alid
ixic
Aci
d (
Log
10)
7
6
5
4
3
2
1
0
Control
* Before E.coli F18 inoculation † Statistical difference (P<0.05)
SPORULIN
Day 1* Day 2 Day 5 Day 8 Day 11
FIGURE 5. Mortality Due to Necrotic Enteritis Decreases with SPORULIN
Mo
rtality
(%
)
18
15
12
9
6
3
0Starter (Day 0-14) Grower (Day 14-28) Finisher (Day 28-35) Withdrawal (Day 35-42) Day 42 Cumulative
Salinomycin Salinomycin + SPORULIN
Coccidiosis Vaccine Coccidiosis Vacci + SPORULIN
TABLE 1. Improved Feed Conversion and Live Weight Gain with ACTIVATE WD
Treatment Day 42 Day 49
Adj. Feed Conversion
Avg. Live Wt. Gain
Adj. Feed Conversion
Avg. Live Wt. Gain
Nonmedicated 1.797 2.557 kg 1.947 3.007 kg
ACTIVATE WD 0.04%
1.768 2.556 kg 1.900 3.013 kg
ACTIVATE WD 0.08%
1.772 2.557 kg 1.910 3.029 kg
Calvert et al., 2014
Stringfellow et al., 2012Internal Trial, 2013
Parker et al., 2011
FIGURE 8. Adjusted Feed Conversion of MINTREX Versus Other Sources
Ad
just
ed
FC
R
1.68
1.64
1.60
1.5640 ppm
Welch et al., 2015
Hydroxy TM SulfateAmino Acid Complex MINTREX
COMPROMISED STRUCTURAL INTEGRITY FROM INCREASED DISEASE
SOLUTION: BOOST STRUCTURAL INTEGRITY AND IMMUNITY
Bird development begins in ovo when the breeder hen transfers essential trace minerals to the embryo. The enrichment of the egg yolk with zinc, copper and manganese results in improved mineralization of the bone and connective tissue in the progeny. Zinc, copper and manganese are required to support collagen, elastin and keratin development that is essential for skeletal health.
Collagen and elastin make up approximately 30 percent of the total protein in birds and are essential for proper development, bird health and well-being. Hundreds of enzyme reactions depend on zinc, copper, and manganese.
Structural integrity includes immunity and cellular health. The challenges of a commercial production environment require birds to have optimal immune function. MINTREX® can lower lesion scores and boost gut health in birds challenged with disease (figure 9).
In addition to improvements in structural integrity, MINTREX chelated trace minerals have demonstrated improved immune
response to viral vaccines and have been shown to have a positive effect on plasma peroxide levels (Figure 10).
FIGURE 9. Improved Tissue Integrity of Birds Supplemented with MINTREX
45
40
35
30
25
20
15
10Day 46 Day 54
Control MINTREX
Gra
de 1
an
d 2
Fo
otp
ad
s, (
%)
FIGURE 10. Strengthened Immune Response with MINTREX
10.0
9.5
9.0
8.5
8.0
7.5
7.0
6.5
7.0
6.5
6.0
5.5
5.0
4.5
4.0
3.5ITM ITMMINTREX MINTREX
P=0.02 P=0.02
Ave
rag
e T
iter
Ave
rag
e T
iter
Infectious Bronchitis Newcastle Disease
ZnZINC
CuCOPPER
MnMANGANESE
found in every tissue of the body
accumulates in the bones
deficiency symptoms: poor growth and reproduction
required for crosslinking collagen
gives strength and elasticity in bone, shell and connective tissues
important for cartilage development
deficiency symptons: shortened, deformed skeletal structures and
slipped tendons referred to as perosis
Manangi et al., 2010 Internal Novus Trial
INCREASED FEED COST DUE TO POOR FEED QUALITY
SOLUTION: IMPROVE FEED QUALITY BY REDUCING FEED OXIDATION
Feed cost accounts for approximately 70 percent of the total cost of broiler production. Stabilization of fats, meals and dietary lipids is critical for production of high quality feed. Properly stabilized fats and ingredients reduce the oxidative loss of energy, vitamins and pigments in feed formulations and promote optimum performance and efficiency of poultry production. Unstabilized ingredients in feeds can result in a variety of gut health issues associated with feed passage and flushing, which in turn lead to poor performance, compromised bird health and increased production cost.
SANTOQUIN® feed preservative is proven to prolong the shelf life of feeds, especially during non-optimal storage conditions (i.e. excess heat, moisture, etc.), leading to improved weight gain and feed conversion rates.
SANTOQUIN is proven to improve feed conversion by two points and to reduce days to six pounds for production efficiency by 1.26 days (Figures 11, 12).
FIGURE 11. 2015 Data: Feed Conversion Ratio with Dried Distillers Grains in Diet
FIGURE 12. 2015 Data: Days to Six Pounds with Dried Distillers Grains in Diet
No SANTOQUIN SANTOQUIN
No SANTOQUIN SANTOQUIN
Average
Average
Jan-15
Jan-15
Feb-15
Feb-15
Mar-15
Mar-15
Apr-15
Apr-15
May-15
May-15
Jun-15
Jun-15
Jul-15
Jul-15
Aug-15
Aug-15
Sep-15
Sep-15
Oct-15
Oct-15
Nov-15
Nov-15
Dec-15
Dec-15
2 pts
1.26 Days
FC
RD
ays
1.90
1.88
1.86
1.84
1.82
1.80
1.78
1.76
1.74
47.0
46.5
46.0
45.5
45.0
44.5
44.0
43.5
43.0
IMPROVE weight gain and FCR
PROLONG SHELF LIFEduring non-optimal storage conditions
Broiler Industry Statistical Reporting Services, 2015
Broiler Industry Statistical Reporting Services, 2015
NOVUS SOLUTIONS FOR POULTRY HEALTH
A supplemental protease enzyme that optimizes digestion and absorption of nutrients, reducing the amount of anti-nutritive factors that pass through to the lower gastrointestinal tract.
A blend of organic acids that creates an environment to support positive microflora balance and helps mitigate bacterial shed and spread.
A direct-fed spore-based microbial that is an effective source of Bacillus subtilis that is proven to reduce pathogen levels and decrease feed conversion.
Delivers the most bioavailable sources of Zn, Cu and Mn for physiological functions including a stronger immune system, improved gut microflora balance as a result of Cu supplementation, and improved oxidative balance.
Manages gut level oxidative stress by stabilizing nutrients to support a healthy environment and improved animal oxidative balance for improved performance. SANTOQUIN also preserves the energy content of fats in complete feeds to optimize feed efficiency and reduce feed cost for gain.
Delivers antimicrobial properties and enhances performance as the leading source of methionine in the North America.
POULTRY PRODUCTION SOLUTIONSConsistent Solutions for Ever Changing Production Demands
Novus International, Inc. • 20 Research Park Dr. • St. Charles, MO 63304 USA • +1.314.576.8886 • www.novusint.com
Products not available in all countries.
NOTICE: While the information contained herein (“Information”) is presented in good faith and believed to be correct as of the date hereof, Novus International, Inc., does not guarantee satisfactory results from reliance upon such Information, disclaims all liability for any loss or damage arising out of any use of this Information or the products to which said Information refers and MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER NATURE WITH RESPECT TO THE INFORMATION OR PRODUCTS, except as set forth in Novus’s standard conditions of sale. Nothing contained herein is to be construed as a recommendation to use any product or process in conflict with any patent, and Novus International, Inc., makes no representation or warranty, express or implied, that the use thereof will not infringe any patent.
® , ALIMET, MHA, SANTOQUIN, CIBENZA, ACTIVATE, SPORULIN, ZORIEN,and MINTREX are trademarks of Novus International, Inc., and are registered in the United States and other countries.TM ACIDOMATRIX is a trademark of Novus International, Inc.© 2017 Novus International, Inc. All rights reserved.562_v1_R
Novus employs a dedicated team of employees and researchers committed to making poultry production more efficient and profitable in the face of ABF
production. The Novus staff has more than 50 PhDs and DVMs dedicated to helping poultry producers realize greater efficiency and profitability. Through partnerships with scientists and universities on a global scale, we invent custom solutions for
enhancing poultry health and producer profitability!
Join us on our journey with Project Horizon!