P R E S E N T E D B Y
#FindingSolutions
P R E S E N T I N G S P O N S O R
G O L D S P O N S O R S
S I L V E R S P O N S O R SDr. Wayne and Donna Anderson
Blue Cross NCNorth Carolina Biotechnology Center
PRA Health Sciences
R U B Y S P O N S O R
B R O N Z E S P O N S O R S
C R Y S T A L S P O N S O R SDr. Shelton EarpElizabeth Savage
Ellis & Winters, LLPGregory B. Williams Foundation
NCCULilly
Lisa SykesPfizer
RTP FoundationValencia Davis
Wake Radiology
Merck
IBMSage Island
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#FindingSolutions
https://www.youtube.com/watch?v=P6HAN-XAcnI
https://www.youtube.com/watch?v=P6HAN-XAcnI
#FindingSolutions
The Changing Face ofBreast Cancer
George W. Sledge MDStanford University School of
Medicine
40,000 Women & Men
per year
Why?
Why Does Breast Cancer Kill and What Can We Do About It?
• What We Know– Local therapy cures many early stage breast cancers– Late stage breast cancer is usually incurable
• What kills?– Disparities– Drug-resistant metastatic disease
Breast Cancer Molecular Subtypes
Courtesy Chuck Perou
Luminal B
Luminal ANormal
breast-likeLumina
l B2 Basal-like HER2+/ER-
Breast cancer is not one disease.But a group of biologically distinct diseases.
What does this mean?
It means that it does not make sense to ask “what causes breast cancer?”
It also means that individualized medicine is not just desirable, it is crucial.
Breast Cancer as Whack-a-Mole
Rapid emergence of resistance
“Here's my sequence...”
The New Yorker
Liquid Biopsy: Circulating Tumor DNA
and Circulating Tumor Cells
CTCs to Detect Late Recurrence of ER-Positive
Breast Cancer: EL112 study• Patients enrolled in parent adjuvant
trial (E5103) underwent single time point blood collection 4.5-7.5 years from diagnosis
• CellSearch (EpCAM) assay performed
• Recurrence rates per person-year:• 21.4% for CTC+ vs 2.0% CTC-
What Cancer Cells Do To T Cells:These aren’t the droids you’re looking for
22
P R E S E N T E D B Y
#FindingSolutions
Dr. Melissa Troester
Co-Principal Investigator Carolina Breast Cancer Study
Co-Leader Lineberger Comprehensive Cancer Center’s Cancer Epidemiology Program
#FindingSolutions
Dr. George SledgeProfessor of Medicine and Chief
Division of Oncology, Stanford University School of Medicine
Co-Director Stanford Cancer Institute’s Translational Oncology Program
#FindingSolutions
Dr. Donald McDonnellCo-Director Women’s Cancer Program,
Duke Cancer Institute
Glaxo-Wellcome Professor of Molecular Cancer Biology
Chairman of the Department of Pharmacology & Cancer Biology at Duke University School of Medicine
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Dr. Charles PerouCo-Director UNC Computational Medicine Program
May Goldman Shaw Distinguished Professor of Molecular Oncology
Professor of Genetics and of Pathology & Laboratory Medicine at the University of North Carolina
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Jen Hoverstad
#FindingSolutions
Breast Cancer SurvivorBrand Manager, Counter Culture Coffee
Attorney at Law
P R E S E N T E D B Y
#FindingSolutions
BOLD GOAL
REDUCTION in current breast cancer deaths
in the U.S. by 2026
50%
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#FindingSolutions
2018 KOMEN NCTC AWARDS
#FindingSolutions
MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD
MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD
MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD
MAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARD
P R E S E N T E D B Y
Thank You!
#FindingSolutions
Slide Number 1PRESENTING SPONSORRUBY SPONSOR���BRONZE SPONSORS�����CRYSTAL SPONSORSSlide Number 4Slide Number 5Slide Number 6Slide Number 7The Changing Face of�Breast CancerSlide Number 9Why Does Breast Cancer Kill and �What Can We Do About It?Slide Number 11Slide Number 12Slide Number 13Breast Cancer as Whack-a-MoleSlide Number 15Slide Number 16Slide Number 17Liquid Biopsy: Circulating Tumor DNA�and Circulating Tumor CellsCTCs to Detect Late Recurrence of ER-Positive Breast Cancer: EL112 studySlide Number 20What Cancer Cells Do To T Cells:�These aren’t the droids you’re looking forSlide Number 22Slide Number 23Dr. Melissa TroesterDr. George SledgeDr. Donald McDonnellDr. Charles PerouSlide Number 28Slide Number 29Slide Number 30Slide Number 312018 KOMEN NCTC �AWARDSMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDMAUREEN THOMAS JORDAN SPIRIT OF SURVIVORSHIP/THRIVERSHIP AWARDSlide Number 37