Primer on the Olfactory Bulb and Antennal Lobe
Brief comparative introduction of:
• Neurons• Synaptic interactions
Olfaction: common evolutionary problems…
…common solutions
The AL and OB: Macroscopic Relations
Brain nerve I
OB projects to various brain centers
J. H. Martin, 1989
The Mammalian Sensory Epithelium
L. Buck and R. Axel (1991)Cell 65, 175-187
Fascicles
Each olfactory receptor neuron (ORN) expresses only one gene coding an odorant receptor protein.
G. M. Shepherd, 2004
The Insect Sensory Epithelium
OB Intrinsic (local) and Principle (output) Neurons
Synaptic interactions within the OB glomeruli
PN (output)+ +
+
cholinergic ORN input
BMI-sensitiveReceptors:
GABAergic LN’s
AL glomerulus
–
D.2.2.1D.2.3.1D.2.3.3
AL’s
Synaptic interactions within the AL glomeruli
AL Intrinsic (local) and Principle (output) Neurons
AL MB
LH
-
-
+
+
+
+
http://www.biozentrum.uni-wuerzburg.de/fileadmin/REPORT/GENET/genet010.htm