Pure Science. Innovative Thinking. Unparalleled Quality 1 “A PARTNERSHIP IN HEALTH & WELLNESS”...

Pure Science. Innovative Thinking. Unparalleled Quality 1

“A PARTNERSHIP IN HEALTH & WELLNESS”

SourceOne Global Partners


Presentation Agenda

• Introductions, SourceOne and Vesifact• What is the VESIsorb® delivery system• How it works, the features and benefits• “Seeing is believing”• Providing science-based solutions…• Global market leadership…


SourceOne Global Partners“Our Success Insures Your Success”

We provide health and wellness solutions, created through scientific research and innovative product development. Our focus is on clinically proven formulations, combined with technologically-advanced and patented delivery systems


The SourceOne Difference

• SourceOne has distinguished itself as a premier innovator of scientifically proven health products and technologies.

• Our leadership team has forged numerous global partnerships and alliances resulting in competitive advantages and added value to the portfolio we bring to the global marketplace.

• The synergies created by these partnerships are directly and immediately applicable to the new products we are introducing and those we are developing.

• The many benefits derived from these innovations and the technology exchange will resonate with our client partners and ultimately the consumer focused on health and wellness.


Exclusive Partnership with World Leader in advanced delivery systems

Through SourceOne’s exclusive partnership with Vesifact, a world leader in micro emulsions, nano-colloids, drug delivery, and other innovative delivery systems, we are a leading solution provider for dramatically improving absorption and bioavailability of poorly absorbed ingredients.


Vesifact Swiss Precision, Closed Loop Sterile Production Facility


The latest breakthrough is VESIsorb®

What is VESIsorb®?

A naturally self-assembling colloidal delivery system that enables us to meet

the growing demand for enhanced bioavailability of unique science-based formulas taking their absorption and

efficacy to the next level.


Self-Assembling Delivery System

• VESIsorb® keeps water insoluble respectively fat soluble molecules in a hydrophilic environment (e.g. water, gastric fluids) in solution.

• VESIsorb® does not change a molecule chemically.• It is a solubilizing vehicle comprising an oil core surrounded by a

monolayer membrane (emulsifiers).• These emulsifiers link the two surface areas between water and

oil. Without “linking molecules”, it is impossible to get a stable oil/water mixture (emulsion).

• This is a dynamic process, no static, and it allows the molecules (emulsifiers, oils, actives) to move perpetually from one droplet to another or other membranes (e.g. enterocytes).


VESIsorb®…Three Step Process


Advantages in Technology•Non-aqueous lipid-basedcomposition containing an active ingredient•On contact with an aqueous phase a colloidal delivery system containing the active ingredients is spontaneously formed (self-assembling)•Superior Characteristics of the colloidal delivery system

•Size <100nm, typically <50nm•Highly uniform size

distributionColloidal solubilized

active

“H2O”

CoQsource®


Patented All-Natural Delivery System

CoQ10(Ubiquinone)

CoQ10 Pre-Colloid Phase

CoQ10 Colloid PhaseCoQsource®


Micelle vs. Liposome vs. Colloidal Delivery System

Liposome• Shell: Bi-Layer

• Core: Water

Colloidal• Shell: Mono-layer

• Core: Oil

Micelle• Shell: Hydrophilic

surfactant head• Core: Hydrophobic

surfactant tail


CoQ10 Bio-enhanced formulations compare absorption data to CoQ10

powders• 3 studies show peak absorption of CoQ10 powder

of .51, .85 and 2.15 average = 1.17• 3 studies using soft gels in oily dispersion show peak

absorption…1.32, 1.76 and 1.98 average = 1.69• 3 studies various delivery systems… 2.24, 3.57, and

4.48 average = 3.43

VESIsorb® colloidal droplet peak absorption… 16.97


Published Study Results

The graph above provides a vivid illustration of the difference in CoQsource® (orange line) versus the three other “bio-enhanced” CoQ10 products in plasma concentration levels after one hour, but continues to increase dramatically before reaching Cmax at about 4 hours. The plasma concentration of CoQsource® remains well above the levels of the 3 other treatments throughout the 23 hour period.


Consistent Clinical ResultsCoQ10 Ubiquinone & Ubiquinol-QH


Consistent PK ResultsOmega-3 EPA/DHA

• OmegaChoice® in the VESIsorb® delivery system turns concentrated Omega-3 EPA/DHA into water soluble colloidal droplets increasing absorption and broadening the possible applications.

• A pharmacokinetic pilot study comparing OmegaChoice® 90 Concentrated Omega-3 EPA to the same OmegaChoice™ 90 in the VESIsorb® delivery system demonstrated an increase of 567% in peak blood levels (cmax) of EPA.

• The relative bioavailability calculated using the area under the curve (AUC 01-12h) was also increase by 487%.



• Consistent advantage of optimal performance under all conditions

• Absorption & bioavailability impacted by– Aging population = nutrient absorption declines

with age– Low-Fat Diet…see Omthera study Lovaza vs.

Epanova – Sickness & Stress negatively impact absorption– More standard capsules = < efficient absorption

Delivers Maximum Benefits


COMPETING CoQ10 PRODUCT

DOES NOT GO INTO SOLUTION

OIL DROPS SITTING ON WATER SEPARATION OF COMPONENTS(NO EMULSIFICATION)

COLLOIDAL DROPLET FORMATION 100% IN SOLUTION! COMPLETELY HOMOGENOUSCOLLOIDAL SOLUTION!


STANDARD TG OMEGA-3 PRODUCT

OIL DROPS SITTING ON WATER

DOES NOT GO INTO SOLUTION

SEPARATION OF COMPONENTS(NO EMULSIFICATION)

COLLOIDAL DROPLET FORMATION

100% IN SOLUTION! COMPLETELY HOMOGENOUSCOLLOIDAL SOLUTION!


Leading CoQ10 and QH Ubiquinol Supplement Brands


Homogeneous Delivery System

• Homogenous versus Heterogeneous

• Speed of conversion• Stability• Reproducibility for

consistency at the consumer level

SourceOne TocoSource® vs. Patented Competitive Tocotrienols


VESIsorb® Fluid Droplets - Cryo Electron Micrograph


VESIFACT HOLDS OVER 40 INTERNATIONAL PATENTS AND PATENTS-PENDING IN OVER

20 COUNTRIES

Vesifact Intellectual Property (IP) and Know How


The following listing is an overview of key U.S and European VESIsorb® oral and topical patents for both pharmaceutical and nutraceutical formulations. Additionally we have patents and patents pending in Japan, China, Hong Kong, Korea, Singapore, Brazil, India, Indonesia, Mexico, Philippines, Russia, Thailand, Taiwan and Argentina. Vesifact Patents & Patent Applications:

• Europe patent 1,249,502…”Microemulsion-preconcentrates, microemulsions and use of such a composition”

• Europe patent 1,249,230…”Microemulsion-preconcentrates, microemulsions comprising coenzyme Q10” for oral and topical application

• Europe patent 852,941…”Nanodispersion cosmetic composition” for topical applications ; any cosmetic active is a candidate

• U.S. patent 5,997,888…”Cosmetic preparations” for improved absorption in topical applications; any cosmetic active is a candidate

• Europe patent 1,249,231…”Pharmaceutical formulations containing anti-inflammatory active ingredients and the use of said formulations”

• Europe patent 956,851…”Use of nanodispersions in cosmetic end formulations” for improved absorption in topical applications; any cosmetic active is a candidate

• U.S. patent 7,008,638…”Use of nanodispersions in cosmetic end formulations”• Europe patent 956,853…”Use of nanodispersions in pharmaceutical end formulations for oral and topical

applications of any pharmaceutical ingredients” • U.S. patent 7,081,253…”Use of nanodispersions in pharmaceutical end formulations for oral and topical

applications of any pharmaceutical ingredients”



What Do Consumers Want?

•To take fewer capsules•To take smaller capsules•To receive the maximum benefits from their supplements•Greater bioavailability & absorption

…With is more!


The VESIsorb® Solution

With VESIsorb®, you need less to achieve more. Fewer soft gels in your daily regimen to achieve better results.

Size Matters

=



• By increasing bioactive absorption, like CoQ10, this in turn reduces the number of soft gels needed per day to achieve blood plasma levels for optimum health and wellness.

• VESIsorb® technology has a green impact on the environment.

• The efficient use of resources results in fewer bottles, less packaging waste and reduced transportation needs.


Patented, clinically proven formulations in leading brands


ADVANCED INNOVATIVE TECHNOLOGIES


Summary


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