Richard L. HuganirDepartment of Neuroscience

Johns Hopkins University School of Medicine Howard Hughes Medical Institute

Making and Erasing Memories

The Brain is a Network of 100 Billion Neurons

The Brain has Quadrillions of Synapses

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Synaptic Transmission

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Synaptic Plasticity at Synapses

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Synaptic Plasticity at Synapses

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Synaptic Plasticity at Synapses

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Synaptic Plasticity at Synapses

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Long-Term Potentiation

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Long-Term Depression

Regulation of Receptor Function

Kibra

Beautiful Synapses

Cranial Window

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Imaging Receptors in Live Mice

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0 hour 1 hour 2 hour 3 hour

Control

Stimulation

Sensory Stimulation Recruits Receptors to Synapses

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Spatial Learning - Water Maze

Before Training After Training

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Fear Learning and Memory - Fear Conditioning

Fear Extinction: a Form of Behavioral Therapy

Extinction Learning

Extinction RetrievalExtinction Learning

Fear Extinction: a Form of Behavioral Therapy

RelapseExtinction RetrievalExtinction Learning

Fear Extinction: a Form of Behavioral Therapy

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Synaptic Plasticity During Fear Learning

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24 Hrs after Fear Learning

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7 Days after Fear Learning

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24 Hrs window after Fear ConditioningmGluR1-Dependent LTD

Ro-0711401: 9H-xanthene-9-carboxylic acid (4-trifluoromethyl-oxazol-2-yl)-amide

Positive Allosteric Modulators of mGluR1

PAM

Regulation of Receptor Function

Kibra

Yoichi ArakiShu-Ling ChiuMonica Coulter

Kirsten BombachMin Dai

Graham DieringHuaqiang Fang

Hana GoldschmidtAhleah Gustina

Lisa Hamm Seok HeoIngie Hong

Natasha Hussain Richard Johnson

Olof LagerlofTrisha Lala Brain Loeper

Bian LiuRichard Roth Raja Sekhar

Kamal SharmaGek Ming SiaMengnan Tian Alyssa TodaLenora Volk

Rebecca WhiteYong Zhang

Huganir Lab

Funding

HHMININDSNIMH

Simons FoundationADRC Pilot Grant