SynergiStic protocol,proven amplified outcomeS

SynergiStic Science to

amplified facial rejuvenation outcomeS

Smart BuSineSS model

HigHly diStinctive offer

N ea uv i ab il i t y

neauvia provideS a diSruptive approacH

and productS to tHe aeStHetic market,

alwayS Supported

By Science,clinical data

and By developing an iconic Brand

tHat appealS to conSumerS.

Established in 2012 as a scientifically-based medical aesthetics company, Neauvia has evolved into a vibrant, high-growth multinational corporation with production sites and subsidiaries in Italy, Switzerland, France, Spain, Poland and US.

Taking control of the aging process is most effective when

supported by the best of all sciences.

to acHieve tH iS goal, neauvia HaS developed compreHenS ive protocolS,

Supported By cl in ical data, tHat comBine rejuvenat ion tHerap ieS and grant cl in ically

proven Super ior reSultS.

This has been possible thanks to the in-house portfolio of

products developed to work SYNERGISTICALLY with each other

and organically with the body to achieve clinically proven

superior results.

TheHOLIST ICA P P R OA C H

1

2

3

4SUPPLEMENTSSUPPLEMENTSa S t e p f u r t H e ri n i n t e g r a t i v e a e S t H e t i c S

r e v o l u t i o n i n H a f i l l e r m a r k e t

NEAUVIA ENHANCEMENT SYSTEM is

designed to support NEAUVIA Smart

Combination Therapy protocols,

helping to enhance results from the

inside out. Using the latest generation

of ingredients, there are expert and

synergistic formulas targeting skin, hair

and body, and providing additional

daily solutions to patients.

FILLERSFILLERS

Neauvia HA fillers are based on a

unique crosslinker technology SMART

CROSSLINKING TECHNOLOGY – with

PEG, that gives our products a

high safety and tolerability profile

and allows our fillers to perfectly

integrate into the various anatomical

planes. Every filler in our line has

been meticulously engineered to

provide specific rheology for precise

treatment of a wide variety of

individualized aesthetic needs.

AESTHETIC AESTHETIC COSMECEUTICALSCOSMECEUTICALS

t o B e c o m B i n e d w i t H n e a u v i a a e S t H e t i c t r e a t m e n t S

Based on advanced knowledge and research on active ingredients, Neauvia Aesthet ic

Cosmeceuticals offer profess ional and exclus ive sk incare: an advanced solut ion for healthy and

youthful- looking sk in, by boost ing natural beauty with safe and effect ive solut ions.

DEVICESDEVICESm a d e f o r

n e a u v i a S m a r t

c o m B i n a t i o n

a p p r o a c H

Neauvia provides

an energy-based range of products

for the aesthet ic and surgical markets.

Neauvia devices are character ized by

s leek, modern design and advanced

electromedical engineer ing in related

f ields such as electrosurgical, radio-

frequency treatment, thermal- l i f t ing, sk in

photo-biost imulat ion and cosmetology.

To turn Holistic Approach into aesthetics reality,

NEAUVIA Research designed Smart Combination Therapy.

Based on Neauvia comprehensive in-house portfolio - fillers,

devices and cosmeceuticals - and through strict protocols, the

different skin layers are synergistically treated to achieve

clinically proven superior results.

NEAUVIA thus invites everyone to their own pro-aging journey

with maximum efficiency, safety, commitment and satisfaction.

evolutionIN THE AESTHETIC

market

tHe firSt synergistic

mid face protocol for amplified

patient outcomes

To perform #Nlift protocol,

find all the products needed

in #Nlift KIT.

Fillers and energy-based devices excluded.

enter

areaS: All face

Hydro DeluxeHA Concentration: 18 mg/mlContains: 0,1% CaHA, Glycine and L-Proline

P R O T O C O L P R O T O C O L S E S S I O N P R O T O C O L P R O T O C O L S E S S I O N1

* Nicola ZERBINATI, Hassan Ibrahim GALADARI, Pawel KUBIK, Sergey IVANOV, Neauvia Symposium - Holistic approach in treating mid-face. Neauvia Smart Combination Therapy (SCT) – IMCAS Paris 2020.** In-vitro efficacy tests, conducted on the final products by an independent laboratory.*** In-vitro tests performed by an independent laboratory.

areaS: All face

Ceramide ShieldRestores the damaged skin following treatments, Helps to reduce redness and irritation***.

areaS: All face

C-ShotEnhances protection as skin stimulationthanks to 3-o-ethyl ascorbic acid,an advanced form of Vit. C (30%)***.

areaS: Mid face

Zaffiro HA Skin Heath Smart Hydro formula.

areaS: All face

Wake Up SkinHelps to restore the proper pH balance of the skin to reducethe risk of irritation.

areaS: All face

New Born SkinEfficiently removes makeupand impurities, without damaging the skin barrier. Leaves the skin perfectly clean.

areaS: All face

Wake Up SkinHelps to restore the proper pH balance of the skin to reducethe risk of irritation.

areaS: All face

New Born SkinEfficiently removes makeupand impurities, without damaging the skin barrier. Leaves the skin perfectly clean.

Skin preparationSkin preparation Skin preparationSkin preparation1. 1.Clean effectively and gently to optimize treatment action.

TreatmentTreatment2.Enhance superficial skin hydration and quality while promoting homeostasis for rejuvenation.

Clean effectively and gently to optimize treatment action.

2 after after1 week1 week

Post TreatmentPost TreatmentPost TreatmentPost Treatment 3.3.Effectively calm the skin right after medical treatment while delivering moisturizing and toning active ingredients.

Effectively calm the skin right after medical treatment while delivering moisturizing and toning active ingredients.

Home careHome care4.Support skin revitalization and reinforce skin barrier - especially antioxidant protection**.

areaS: All face

Rigen Restore Mask100% sterile.

areaS: All face

Rigen Restore Mask100% sterile.

▶ Oligipeptide-1,2▶ Polipeptide 1,3,5,9,11

▶ Copper Tripeptide-1▶ Hyaluronic Acid

Key Ingredients:▶ Oligipeptide-1,2▶ Polipeptide 1,3,5,9,11

▶ Copper Tripeptide-1▶ Hyaluronic Acid

Key Ingredients:

TreatmentTreatment2.

areaS: Mid face and nasolabial fold

Fillers treatmentINTENSE - HA Concentration: 28 mg/mlContains: Glycine and L-Proline

STIMULATE - HA Concentration: 26 mg/mlContains: 1% CaHA, Glycine and L-Prolin

INTENSE LV - HA Concentration: 26 mg/mlContains: Glycine and L-Proline

• Exfoliate, drain and topically infuse the skin with HA.

• Tighten by stimulating long term neocollagenesis*.Restore volume and support skin regeneration*.

A reduction of inflammation in tissues is noted when using Neauvia fillers over

Zaffiro monotherapy. The smallest inflammatory infiltrate is noted in the group of

patients undergoing combined therapy. This is most likely due to the presence of

PEG together with Hyaluronic Acid based fillers after the inflammatory infiltrating

agent has appeared.

INFLAMMATORY INFILTRATE Mononuclear cells

0

0,6

1,2

1,8

Before 5 days a�er procedure 21 days a�er procedure

2,4

Za�ro

Fillers

#NLIFT

+52%

ma r k e r S o f i n f l a m m at i o n

21 days after 1 treatment with Zaffiro

21 days after undergoing full #NLIFT protocol

COMPARISON OF MONOCYTES AND MACROPHAGES (CD68) EXPRESSION Patient, 61 years old

Both Zaffiro and fillers monotherapy as well as combined therapy cause, in the first

stage, an increase in CD68 expression, which is associated with an increased pre-

sence of monocytes and macrophages in the tissue. However, in procedures using

PEG products, and 21 days after the procedure, not only the return of CD68 expres-

sion to the level before the procedure has been noted, but even its reduction to a

level lower than before the procedure.

Za�ro

Fillers

#NLIFT0%

3%

6%

9%

12%

Before 5 days a�er procedure 21 days a�er procedure

-12%

Immediately before the procedure

21 days after full #NLIFT protocol

& Physiopathology analysis*

IN-VIVO STUDY

How have we proven better Aesthetic Outcomes?

A revolutionary synergy between neAuviA

Device, Fillers AnD cosmeceuticAls:+ 101% fibroblasts after 21 days*.

signiFicAnt superior regenerAtion results with lower skin inflammation.

Angiogenesisimprovement

FibroblAsts

+101%

skin hyDrAtion

+45%

skin elAsticity

+60%

inFlAmmAtoryinFiltrAte

mononucleAr cells

+52%

monocytes &mAcrophAges

-12%

lymphocytes t

-42%

lymphocytes b

-67%

Markers of Skin Rejuvenation

Efficacy

Markers of Inflammation

Safety*Nicola ZERBINATI, Hassan Ibrahim GALADARI, Pawel KUBIK, Sergey IVANOV, Neauvia Symposium - Holistic approach in treating mid-face. Neauvia Smart Combination Therapy (SCT) – IMCAS Paris 2020.

PRESENCE OF FIBROBLASTS(Vimentin, scale from 0 to 4)

The increase in fibroblasts is a direct evidence of collagen production increase in the skin. For both Zaffiro monothe-

rapy and combined therapy (#Nlift), the increase in skin fibroblasts is significant and confirms ongoing revitalization.

0 2,551,70,85 3,4

Za�ro #NLIFT

Before

5 days a�erprocedure

21 days a�erprocedure +101%

+40%

ma r k e r S o f Sk i n re j u v e n at i o n

Immediately before the procedure 21 days after full #NLIFT protocol

PEG has an immunomodulatory effect expressed by a decrease in CD8 protein expression, i.e. a smaller percentage

of cytotoxic T lymphocytes present. This is very important from the perspective of Hyaluronic Acid fillers safety,

as it minimizes the risk of product detection as a foreign body, thus the formation of granulomas.

COMPARISON OF LYMPHOCYTES T (CD8) EXPRESSION Patient, 61 years old

0%

2%

4%

5%

7%

Before 5 days a�er procedure 21 days a�er procedure

Za�ro

Fillers

#NLIFT

-42%

Immediately before the procedure 21 days after full #NLIFT protocol

ANGIOGENESIS IMPROVEMENTincreaSe in cd 31 expreSSion

COMPARISON OF LYMPHOCYTES B (CD20) EXPRESSION Patient, 61 years old

Infrared radiation showed no effect on CD20 expression. As for the procedure based solely on Hyaluronic Acid

products, and due to the simultaneous performance of mesotherapy and fillers, there is a slight increase in CD20

expression on the 5th day after the procedure or treatment, but no longer noticeable on the 21st day after the surgery.

Za�ro

Fillers

#NLIFT 0,00%

0,25%

0,50%

0,75%

1,00%

Before 5 days a�er procedure 21 days a�er procedure

-67%

Immediately before the procedure 21 days after full #NLIFT protocol

COMPARISON ON HYDRATION AND ELASTICITY

0%

15%

30%

45%

60%

ZAFFIRO FILLERS

HYDRATION

+45%

+60%

+25%

ELASTICITY

#NLIFT

0%

15%

30%

45%

60%

ZAFFIRO FILLERS #NLIFT

Before 21 days after full #NLIFT protocol

& the PEGrevolution

Focus on Fillers

Neauvia fillers are based on a unique SMART CROSSLINKING TECHNOLOGY – with PEG,

which creates a flexible product that integrates into the skin to give a natural look,

resistant to compression & stress, providing durability and optimal aesthetic correction

which requires less volume to be injected.

peg makeS neauvia

tHe diStinctive and unique product on tHe market

tHankS to itS unique

propertieS and Safety profile.

Natural result forpatient satisfaction

Less edema: no over correction& need for “touch up”.Stable correction,that will not modify

Longer lasting

Optimal aestheticresults with lessproduct injected Enhanced e�ect from

combinationproducts (molecule& devices)

High safety pro�le

Reduced riskof granulomas

ClinicalOutcomes

1 x 1 ml 1 x 1 ml

HYALURONICACID CONTENT

28 mg/ml 26 mg/ml 28 mg/ml 28 mg/ml 28 mg/ml 18 mg/ml

Glycine and L-Proline

Glycine and L-Proline

Glycine and L-Proline

Glycine and L-Proline

Glycine and L-Proline,1% CaHA

Glycine and L-Proline

0,01% CaHA

21 G22 G

High

21 G22 G

Medium/High

1 x 1 ml

21 G27 G

High

1 x 1 ml

21 G22 G

High

1x2,5ml 2x1ml

21 G22 G

Medium/High

1x2,5ml2x1ml

30 G

Low

Adds structure& lifting

Createsa volumizing

effect

Intimatearea

rejuvenation

Add structure& lifting

Replaces lost volume

Improves skin quality

INTENSE INTENSELV

INTENSEROSE

INTENSEMAN

STIMULATEMAN

HYDRODELUXE MAN

AMINO ACIDSAND CALCIUMHYDROXIAPATITE

SYRINGE

NEEDLE/CANNULA

EXTRUSIONFORCE

EFFECT

INJECTIONPLANE

Neauvia Fillers RangeFillers involved in #Nlift

26 mg/ml

Glycine and L-Proline,1% CaHA

1 x 1 ml

21 G22 G

Medium/High

Replace mid face fat pad lost volume in older

patients

STIMULATE

1 x 1 ml

22 mg/ml

Glycine and L-Proline

27 G

Medium

Fills fine lines & wrinkles

INTENSERHEOLOGY

18 mg/ml

Glycine and L-Proline

0,01% CaHA

1x2,5ml2x1ml

30 G

Low

Improves skin quality

HYDRODELUXE

1 x 1 ml

26 mg/ml

Glycine and L-Proline

27-30 G

Low

Creates a volumizing effect

in the dermis

INTENSE FLUX

1 x 1 ml

24 mg/ml

Glycine and L-Proline

27 G

Medium

Fills fine lines & wrinkles

INTENSELIPS

Focus on Neauvia Devices

1 ZaffiroSmart Infrared tIghtenIng

and Smarthydro

2 Plasma IQPortable mIcro electro Surgery

3 SectummultI-PurPoSe rf SolutIon

1

2

3

Neauvia precision Careful control and adjustment of energy delivery

▶ To optimize treatments for both results and patient comfort

▶ Facilitating the use for medical staff

Neauvia versatility Comprehensive design to treat safely and effectively

a variety of indications and areas.

Neauvia practicality Ease of use and competitive pricing that helps providers

offer world-class treatments at reasonable prices.

Neauvia in-house Engineering & Concierge service

Neauvia provides an energy-based range of

products for the aesthetic and surgical markets,

combining advanced electro medical engineering

and a sleek and modern design.

DEVICESMADE FOR

THE NEAUVIA COMBINATION

APPROACH

neauvia deviceS are BaSed on a tecHnology

Specifically deSigned and Built in, delivering tHe

BeSt reSultS and enSuring maximum patient Safety.

FDA FDA APPROVED!APPROVED!

FDA FDA APPROVED!APPROVED!

SMARTSMARTHYDROHYDROFinely adapted hydro-exfoliation phase

thanks to 5 different types of water

peelings : HA Skin Health, Acne formula,

Soothing Skin formula, Skin Brightening

and Hair nourishment.

▶ patientS 18 and up

▶ prejuvenation + traditional patient

▶ well tolerated witH little to no downtime

▶ treat face and Body

SMARTSMARTINFRAREDINFRAREDTIGHTENINGTIGHTENINGThe Infrared emitted radiation works on the

deep layers of the skin, heating them up and

causing shrinking of collagen and elastin fibers

as providing a global revitalisation effect. This

tightening optimized treatment :

▶ Reduces the appearance of fine lines and wrinkles

▶ Improves elasticity, resilience and texture

▶ Up to 40% increase of fibroblasts and 25% increase

on firmness 21 days post treatment in an in-vivo

clinical study*.

ZAFFIRO Smart Hydroand Smart Infrared Tightening

«A 40 minutes comfortableexperience for visible results. Zaffiro scores with an effective, state-of-the-art treatmentfor unwanted skin laxitywith little to no downtime.»

Dr. Joshua Weitz, NY

*Nicola ZERBINATI, Hassan Ibrahim GALADARI, Pawel KUBIK, Sergey IVANOV, Neauvia Symposium - Holistic approach in treating mid-face. Neauvia Smart Combination Therapy (SCT) – IMCAS Paris 2020.

FDA APPROVED!FDA APPROVED!

Focus on Neauvia Cosmeceuticals

NEAUVIA ADVANCED CARE SYSTEM IS DESIGNED AS AESTHETIC COSMECEUTICALS.

S Y S T E MADVANCED CARE

C-SHOTFOCUS ON

30% 3-o-ethyl Ascorbic AciD

Multi-active and potent molecule

compared to L-ascorbic acid

▶ Stability and absorption

▶ Antioxidant and anti-pollution protection

▶ Dark spot correction and skin tone improvement

▶ In-vitro collagen synthesis stimulation

light FormulAtionwith Amphiphilic properties

Enhanced penetration and efficacy even on

combination to oily skin

in-vitro tests results

▶ Significant decrease of melanin content (-15,52%)

from 4 days of use*

▶ DNA photoprotective effect*

▶ Highly significant increase in collagen synthesis

from 24h of treatment*

3 TO 5 DROPS EVERY DAY AND NIGHT

* In-vitro tests performed by an independent laboratory.

Formulated by doctors to doctors to specifically work with aesthetic procedures, aims to:

neauvia advanced care SyStem productS are game cHanger BotH aS an intenSive treatment and aS a daily routine.

day By day, tHe Skin BecomeS Hydrated, BrigHtened, StrengtHened and revitalized.

▶ Enhance procedure outcomes

▶ Decrease downtime and reduce the feeling of discomfort

▶ Support skin healing process after procedures

▶ Provide excellent results in a shorter time.

It is based on specific advanced active

substances - Fractionated HA, Growth fac-

tors, 3-O-Ethyl ascorbic acid, Retin Com-

plex, Glutathione - that are formulated at

high concentration and with sophisticated

active delivery systems - liposomes, nano-

somes and hydroxisomes.

«A highly concentrated serumthat keeps its promises»

Dr. Kubik, Gdynia

▶ Ceramide Complex: Ceramide 1, 6 ii,phytosphingosine, Cholesterol

▶ heptapetide-4, heptapeptide-10

▶ Centella asiatiCa leaf extraCt

Enhanced results thanks to the Ceramid Complex blend,a skin-like lipid concentrate and a prebiotic peptide

▶ Lasting moisture

▶ Alleviation of skin irritation

▶ Skin resilience improvement

▶ Diminished visibility of wrinkles

Double restorAtion oF skin’s protective bArrier: epiDermis + microbiotA

Advanced and light formula, improving skin healing, suitable even for skin with redness and atopy

in-vitro tests results

▶ Significant decrease in interleukin-6 production after

24h of treatment - soothing effect*

▶ Moisturizing effect*

▶ Remarkable increase in collagen and elastin

production after 24 h of treatment*

CERAMIDESHIELD

FOCUS ON

1-2 PUMPS EVERY DAY AND NIGHT

* In-vitro tests performed by an independent laboratory.

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