SAFETY DATA SHEET Page: 1 of 6 AMP+ Derivatizing Reagent … · 2016. 7. 6. · Revision:...

07/06/2016Revision:

Page: 1 of 6

AMP+ Derivatizing ReagentSAFETY DATA SHEET

01/14/2015Supersedes Revision:

according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/2008

7100011.1 Product Code:

Section 1. Identification of the Substance/Mixture and of the Company/Undertaking

AMP+ Derivatizing Reagent Product Name:

Cayman Chemical CompanyCompany Name:1180 E. Ellsworth Rd.Ann Arbor, MI 48108

CHEMTREC Within USA and Canada:Emergency Contact: +1 (800)424-9300CHEMTREC Outside USA and Canada: +1 (703)527-3887

Cayman Chemical CompanyInformation: +1 (734)971-3335

For research use only, not for human or veterinary use.Relevant identified uses:

www.caymanchem.comWeb site address:

1.3 Details of the Supplier of the Safety Data Sheet:

1.2 Relevant identified uses of the substance or mixture and uses advised against:

1.4 Emergency telephone number:

Section 2. Hazards Identification

Flammable Liquids, Category 2Acute Toxicity: Inhalation, Category 4Acute Toxicity: Oral, Category 4Acute Toxicity: Skin, Category 4Serious Eye Damage/Eye Irritation, Category 2

2.1 Classification of the Substance or Mixture:

H225: Highly flammable liquid and vapor.H332: Harmful if inhaled.H302: Harmful if swallowed.H312: Harmful in contact with skin.H319: Causes serious eye irritation.

GHS Hazard Phrases:

2.2 Label Elements:

DangerGHS Signal Word:

P210: Keep away from {heat/sparks/open flames/hot surfaces}. - No smoking.P280: Wear {protective gloves/protective clothing/eye protection/face protection}.P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.P264: Wash {hands} thoroughly after handling.P362+364: Take off contaminated clothing and wash it before reuse.

GHS Precaution Phrases:

P303+361+353: IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin withwater/shower.P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.P312: Call a {POISON CENTER/doctor/...} if you feel unwell.

GHS Response Phrases:

Multi-region format

07/06/2016Revision:

Page: 2 of 6


01/14/2015Supersedes Revision:P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.P330: Rinse mouth.P302+352: IF ON SKIN: Wash with plenty of soap and water.P321: Specific treatment {see ... on this label}.P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easyto do. Continue rinsing.P337+313: If eye irritation persists, get medical advice/attention.

Please refer to Section 7 for Storage and Section 13 for Disposal information.GHS Storage and Disposal Phrases:

2.3 Can cause fatal cyanide poisoning.Causes serious eye irritation.Harmful if swallowed, inhaled, or absorbed through the skin.Material may be irritating to the mucous membranes and upper respiratory tract.May be fatal if swallowed, inhaled, or absorbed through the skin.May cause skin or respiratory system irritation.Several hours may elapse from exposure to onset of symptoms.To the best of our knowledge, the toxicological properties have not been thoroughly investigated.

Adverse Human HealthEffects and Symptoms:

CAS # /RTECS #

Hazardous Components (Chemical Name)/REACH Registration No.

Section 3. Composition/Information on IngredientsConcentration EC No./

EC Index No.GHS Classification

NANA

AMP+ Derivatizing Reagent 0.0 -1.0 % NA NA

No data available.

75-05-8AL7700000

Acetonitrile 99.0 -100.0 % 200-835-2 608-001-00-3

Flam. Liq. 2: H225Acute Tox.(O) 4: H302Acute Tox.(D) 4: H312Eye Damage 2: H319Acute Tox.(I) 4: H332

4.2

Section 4. First Aid MeasuresDescription of First AidMeasures:

Exposure may cause: asphyxia, cyanosis, depression, diarrhea, dizziness, drowsiness, excitement,headache, impaired judgement, lack of coordination, nausea, rash, vomiting, stupor, death.Treat as cyanide poisoning. Always have on hand a cyanide first-aid kit, together with properinstructions. The onset of symptoms is generally delayed pending conversion to cyanide.

Important Symptoms andEffects, Both Acute andDelayed:

Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Have eyes examinedand tested by medical personnel.

In Case of Eye Contact:

Immediately wash skin with soap and plenty of water for at least 15 minutes. Remove contaminatedclothing. Get medical attention if symptoms occur. Wash clothing before reuse.

In Case of Skin Contact:

Wash out mouth with water provided person is conscious. Never give anything by mouth to anunconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so bymedical personnel.

In Case of Ingestion:

Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel.Get immediate medical attention.

In Case of Inhalation:

4.1

Acetonitrile is metabolized to cyanide. Patients with significant exposures must be observed forsigns of cyanide poisoning and treated accordingly.

Note for the Doctor:

Multi-region format

07/06/2016Revision:

Page: 3 of 6



5.1

5.2

Section 5. Fire Fighting Measures

Flash Pt: 2.00 C Method Used: Closed Cup

As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved orequivalent), and full protective gear to prevent contact with skin and eyes.Note: Flammable as diluted in acetonitrile

Fire Fighting Instructions:

Autoignition Pt: 524.00 CExplosive Limits: LEL: 3.0% at 25.0 C UEL: 16.0% at 25.0 C

Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray.Use water spray to cool fire-exposed containers.

Suitable ExtinguishingMedia:

A solid water stream may be inefficient.Unsuitable ExtinguishingMedia:

Can release vapors that form explosive mixtures at temperatures at or above the flashpoint.Container explosion may occur under fire conditions.Emits toxic fumes under fire conditions.Sensitive to static discharge.Vapors can travel to a source of ignition and flash back.

Flammable Properties andHazards:

5.3

No data available.

6.3

6.1

6.2

Section 6. Accidental Release Measures

Contain spill and collect, as appropriate.Transfer to a chemical waste container for disposal in accordance with local regulations.

Methods and Material ForContainment and CleaningUp:

Avoid breathing vapors and provide adequate ventilation.As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or respirator,and appropriate personal protection (rubber boots, safety goggles, and heavy rubber gloves).

Protective Precautions,Protective Equipment andEmergency Procedures:

Take steps to avoid release into the environment, if safe to do so.EnvironmentalPrecautions:

7.1

7.2

Section 7. Handling and StorageAvoid breathing dust/fume/gas/mist/vapours/spray.Avoid prolonged or repeated exposure.Keep away from sources of ignition.Take precautionary measures against static discharge.

Precautions To Be Takenin Handling:

Keep away from heat, sparks and flame.Keep container tightly closed.Store in accordance with information listed on the product insert.

Precautions To Be Takenin Storing:

Section 8. Exposure Controls/Personal Protection

Britain EH40 France VLCAS # Partial Chemical Name Europe

8.1 Exposure Parameters:

No data. No data. NA AMP+ Derivatizing Reagent No data.

TWA: 68 mg/m3 (40 ppm)STEL: 102 mg/m3 (60 ppm)

TWA: 70 mg/m3 (40 ppm)STEL: ()

75-05-8 Acetonitrile TWA: 70 mg/m3

Multi-region format

07/06/2016Revision:

Page: 4 of 6



OSHA TWA ACGIH TWACAS # Partial Chemical Name Other Limits

No data. No data. NA AMP+ Derivatizing Reagent No data.

PEL: 40 ppm TLV: 20 ppm 75-05-8 Acetonitrile No data.

8.2.1

NIOSH approved respirator, as conditions warrant.Respiratory Equipment(Specify Type):

Safety glassesEye Protection:Compatible chemical-resistant glovesProtective Gloves:Lab coatOther Protective Clothing:

Use process enclosures, local exhaust ventilation, or other engineering controls to control airbornelevels below recommended exposure limits.

Engineering Controls(Ventilation etc.):

Do not take internally.Facilities storing or utilizing this material should be equipped with an eyewash facility and a safetyshower.Wash thoroughly after handling.

Work/Hygienic/Maintenance Practices:

No data available.

8.2 Exposure Controls:

8.2.2 Personal protection equipment:

Section 9. Physical and Chemical Properties

Physical States: [ ] Gas [ X ] Liquid [ ] Solid

Melting Point: No data.Boiling Point: No data.Flash Pt: 2.00 C Method Used: Closed Cup

Explosive Limits: LEL: 3.0% at 25.0 C UEL: 16.0% at 25.0 CVapor Pressure (vs. Air or mmHg):

73 MM_HG at 20.0 C

Vapor Density (vs. Air = 1): No data.

Evaporation Rate: No data.

SolutionAppearance and Odor:

9.1 Information on Basic Physical and Chemical Properties

Flammability (solid, gas): No data available.

Specific Gravity (Water = 1): No data.Solubility in Water: No data.

Autoignition Pt: 524.00 C

Percent Volatile: No data.9.2 Other Information

10.4

10.5

10.110.210.3

Section 10. Stability and Reactivity

heat, flames and sparksConditions To Avoid:

Unstable [ ] Stable [ X ]Stability:

acidsalkali metalsbasesoxidizing agents

Incompatibility - MaterialsTo Avoid:

Will occur [ ] Will not occur [ X ]Polymerization:

Stable if stored in accordance with information listed on the product insert.Stability Note(s):

No data available.Reactivity:

Multi-region format

07/06/2016Revision:

Page: 5 of 6



10.6

reducing agents

carbon dioxidecarbon monoxidehydrogen cyanidenitrogen oxides

HazardousDecomposition orByproducts:

11.1

CAS # Hazardous Components (Chemical Name) NTP

Section 11. Toxicological InformationThe toxicological effects of this product have not been thoroughly studied.Acetonitrile - Toxicity Data: Oral LD50 (rat): 2,460 mg/kg; Oral LD50 (mouse): 269 mg/kg; OralLD50 (rabbit): 50 mg/kg; Oral TDLO (man): 64 mg/kg; Skin LD50 (rabbit): 980 mg/kg; InhalationTCLO (human): 160 ppm (4h); Inhalation LC50 (rat): 7,551 ppm (8h);Acetonitrile - Irritation Data: Skin (rabbit) 500 mg mild; Eye (rabbit): 100 ìl (24 hr) moderate;

Information onToxicological Effects:

Acetonitrile - Investigated as a mutagen, reproductive effector, and tumorigen.Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here.See actual entry in RTECS for complete information.Acetonitrile RTECS Number: AL7700000

Chronic ToxicologicalEffects:

IARC ACGIH OSHA

NTP? No IARC Monographs? No OSHA Regulated? NoCarcinogenicity:

NA AMP+ Derivatizing Reagent n.a. n.a. n.a. n.a.

75-05-8 Acetonitrile n.a. n.a. A4 n.a.

12.1

12.2

12.3

12.4

12.5

Avoid release into the environment.Runoff from fire control or dilution water may cause pollution.

Toxicity:

Section 12. Ecological Information

No data available.Persistence andDegradability:

No data available.BioaccumulativePotential:

No data available.Mobility in Soil:

No data available.Results of PBT and vPvBassessment:

12.6 No data available.Other adverse effects:

13.1 Dispose in accordance with local, state, and federal regulations.Waste Disposal Method:

Section 13. Disposal Considerations

Section 14. Transport Information

Acetonitrile SolutionDOT Proper Shipping Name:3 FLAMMABLE LIQUIDDOT Hazard Class:1648UN/NA Number: IIPacking Group:

14.1 LAND TRANSPORT (US DOT):

Multi-region format

07/06/2016Revision:

Page: 6 of 6



Acetonitrile SolutionADR/RID Shipping Name:

14.1 LAND TRANSPORT (European ADR/RID):

1648UN Number: IIPacking Group:3 - FLAMMABLE LIQUIDHazard Class:

Acetonitrile SolutionICAO/IATA Shipping Name:

14.3 AIR TRANSPORT (ICAO/IATA):

1648UN Number: IIPacking Group:3 - FLAMMABLE LIQUIDHazard Class: 3IATA Classification:

Transport in accordance with local, state, and federal regulations.When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code ofE1, E2, E4, or E5, this item meets the De Minimis Quantities exemption, per IATA 2.6.10.Therefore packaging does not have to be labeled as Dangerous Goods/Excepted Quantity.

Additional TransportInformation:

CAS # Hazardous Components (Chemical Name)

Section 15. Regulatory Information

S. 302 (EHS) S. 304 RQ S. 313 (TRI)

EPA SARA (Superfund Amendments and Reauthorization Act of 1986) Lists

NA AMP+ Derivatizing Reagent No No No

75-05-8 Acetonitrile No Yes 5000 LB Yes

CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists NA AMP+ Derivatizing Reagent CAA HAP,ODC: No; CWA NPDES: No; TSCA: No; CA

PROP.65: No

75-05-8 Acetonitrile CAA HAP,ODC: HAP; CWA NPDES: No; TSCA: Yes -Inventory, 4 Test, 8A PAIR; CA PROP.65: No

Section 16. Other Information

No data available.Additional Information AboutThis Product:

DISCLAIMER: This information is believed to be accurate and represents the best informationcurrently available to us. However, we make no warranty of merchantability or any other warranty,express or implied, with respect to such information, and we assume no liability resulting from itsuse. Users should make their own investigations to determine the suitability of the information fortheir particular purposes.

Company Policy or Disclaimer:

07/06/2016Revision Date:

Multi-region format

07/06/2016Revision:

Page: 1 of 6

HOBtSAFETY DATA SHEET





HOBt Product Name:










Flammable Liquids, Category 2Acute Toxicity: Inhalation, Category 4Acute Toxicity: Oral, Category 4Acute Toxicity: Skin, Category 4Serious Eye Damage/Eye Irritation, Category 2


H225: Highly flammable liquid and vapor.H332: Harmful if inhaled.H302: Harmful if swallowed.H312: Harmful in contact with skin.H319: Causes serious eye irritation.

GHS Hazard Phrases:

2.2 Label Elements:


P210: Keep away from {heat/sparks/open flames/hot surfaces}. - No smoking.P280: Wear {protective gloves/protective clothing/eye protection/face protection}.P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.P264: Wash {hands} thoroughly after handling.P362+364: Take off contaminated clothing and wash it before reuse.


P303+361+353: IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin withwater/shower.P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.P312: Call a {POISON CENTER/doctor/...} if you feel unwell.


Multi-region format

07/06/2016Revision:

Page: 2 of 6


01/14/2015Supersedes Revision:P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.P330: Rinse mouth.P302+352: IF ON SKIN: Wash with plenty of soap and water.P321: Specific treatment {see ... on this label}.P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easyto do. Continue rinsing.P337+313: If eye irritation persists, get medical advice/attention.


2.3 Can cause fatal cyanide poisoning.Causes serious eye irritation.Harmful if swallowed, inhaled, or absorbed through the skin.Material may be irritating to the mucous membranes and upper respiratory tract.May be fatal if swallowed, inhaled, or absorbed through the skin.May cause skin or respiratory system irritation.Several hours may elapse from exposure to onset of symptoms.To the best of our knowledge, the toxicological properties have not been thoroughly investigated.


CAS # /RTECS #




2592-95-2DM1288000

1-Hydroxybenzotriazole 0.0 -0.5 % 219-989-7 613-285-00-7

Explosive 1.3: H203

75-05-8AL7700000

Acetonitrile 99.0 -100.0 % 200-835-2 608-001-00-3


4.2


Exposure may cause: asphyxia, cyanosis, depression, diarrhea, dizziness, drowsiness, excitement,headache, impaired judgement, lack of coordination, nausea, rash, vomiting, stupor, death.Treat as cyanide poisoning. Always have on hand a cyanide first-aid kit, together with properinstructions. The onset of symptoms is generally delayed pending conversion to cyanide.










4.1



Multi-region format

07/06/2016Revision:

Page: 3 of 6



5.1

5.2


Flash Pt: 2.00 C Method Used: Closed Cup

As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved orequivalent), and full protective gear to prevent contact with skin and eyes.Note: Flammable as diluted in acetonitrile


Autoignition Pt: 524.00 CExplosive Limits: LEL: 3.0% at 25.0 C UEL: 16.0% at 25.0 C






5.3

No data available.

6.3

6.1

6.2







7.1

7.2








No data. No data. 2592-95-2 1-Hydroxybenzotriazole No data.




Multi-region format

07/06/2016Revision:

Page: 4 of 6




No data. No data. 2592-95-2 1-Hydroxybenzotriazole No data.


8.2.1







No data available.





Melting Point: No data.Boiling Point: No data.Flash Pt: 2.00 C Method Used: Closed Cup

Explosive Limits: LEL: 3.0% at 25.0 C UEL: 16.0% at 25.0 CVapor Pressure (vs. Air or mmHg):

73 MM_HG at 20.0 C







Autoignition Pt: 524.00 C


10.4

10.5

10.110.210.3




acidsalkali metalsbasesoxidizing agents





Multi-region format

07/06/2016Revision:

Page: 5 of 6



10.6

reducing agents



11.1


Section 11. Toxicological InformationThe toxicological effects of this product have not been thoroughly studied.Acetonitrile - Toxicity Data: Oral LD50 (rat): 2,460 mg/kg; Oral LD50 (mouse): 269 mg/kg; OralLD50 (rabbit): 50 mg/kg; Oral TDLO (man): 64 mg/kg; Skin LD50 (rabbit): 980 mg/kg; InhalationTCLO (human): 160 ppm (4h); Inhalation LC50 (rat): 7,551 ppm (8h);Acetonitrile - Irritation Data: Skin (rabbit) 500 mg mild; Eye (rabbit): 100 ìl (24 hr) moderate;


Acetonitrile - Investigated as a mutagen, reproductive effector, and tumorigen.Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here.See actual entry in RTECS for complete information.Acetonitrile RTECS Number: AL7700000


IARC ACGIH OSHA


2592-95-2 1-Hydroxybenzotriazole n.a. n.a. n.a. n.a.


12.1

12.2

12.3

12.4

12.5


Toxicity:










Acetonitrile SolutionDOT Proper Shipping Name:3 FLAMMABLE LIQUIDDOT Hazard Class:1648UN/NA Number: IIPacking Group:


Multi-region format

07/06/2016Revision:

Page: 6 of 6



Acetonitrile SolutionADR/RID Shipping Name:



Acetonitrile SolutionICAO/IATA Shipping Name:







S. 302 (EHS) S. 304 RQ S. 313 (TRI)


2592-95-2 1-Hydroxybenzotriazole No No No


CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists 2592-95-2 1-Hydroxybenzotriazole CAA HAP,ODC: No; CWA NPDES: No; TSCA: Yes -

Inventory; CA PROP.65: No







Multi-region format

07/06/2016Revision:

Page: 1 of 6

EDCSAFETY DATA SHEET





EDC Product Name:










Skin Corrosion/Irritation, Category 2Serious Eye Damage/Eye Irritation, Category 2Specific Target Organ Toxicity (single exposure), Category 3


H315: Causes skin irritation.H319: Causes serious eye irritation.H335: May cause respiratory irritation.

GHS Hazard Phrases:

2.2 Label Elements:

WarningGHS Signal Word:

P261: Avoid breathing {dust/fume/gas/mist/vapors/spray}.P264: Wash {hands} thoroughly after handling.P280: Wear {protective gloves/protective clothing/eye protection/face protection}.


P302+352: IF ON SKIN: Wash with plenty of soap and water.P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easyto do. Continue rinsing.P312: Call a POISON CENTER or doctor/physician if you feel unwell.P332+313: If skin irritation occurs, get medical advice/attention.P337+313: If eye irritation persists, get medical advice/attention.P362+364: Take off contaminated clothing and wash it before reuse.



Multi-region format

07/06/2016Revision:

Page: 2 of 6



2.3 Causes serious eye irritation.Causes skin irritation.Material may be irritating to the mucous membranes and upper respiratory tract.May be harmful by inhalation, ingestion, or skin absorption.May cause respiratory system irritation.To the best of our knowledge, the toxicological properties have not been thoroughly investigated.


CAS # /RTECS #




25952-53-8FF2200000

EDC{1-(3-(Dimethylamino)propyl)-3-ethyl-carbodiimidehydrochloride; EDAP; WSC}

10.0 -20.0 % 247-361-2 NA

Skin Corr. 2: H315Eye Damage 2: H319STOT (SE) 3: H335 H336

7732-18-5ZC0110000

Water 80.0 -90.0 % 231-791-2 NA

No data available.










4.1

5.1

5.2


Flash Pt: No data.

As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved orequivalent), and full protective gear to prevent contact with skin and eyes.


Autoignition Pt: No data.Explosive Limits: LEL: No data. UEL: No data.




No data available.Flammable Properties andHazards:

5.3

No data available.

Multi-region format

07/06/2016Revision:

Page: 3 of 6



6.3

6.1

6.2







7.1

7.2

Section 7. Handling and StorageAvoid breathing dust/fume/gas/mist/vapours/spray.Avoid prolonged or repeated exposure.


Keep container tightly closed.Store in accordance with information listed on the product insert.





No data. No data. 25952-53-8 EDC{1-(3-(Dimethylamino)propyl)-3-ethyl-carbodiimide hydrochloride; EDAP; WSC}

No data.

No data. No data. 7732-18-5 Water No data.


No data. No data. 25952-53-8 EDC{1-(3-(Dimethylamino)propyl)-3-ethyl-carbodiimide hydrochloride; EDAP; WSC}

No data.

No data. No data. 7732-18-5 Water No data.

8.2.1







No data available.



Multi-region format

07/06/2016Revision:

Page: 4 of 6





Melting Point: No data.Boiling Point: No data.Flash Pt: No data.

Explosive Limits: LEL: No data. UEL: No data.Vapor Pressure (vs. Air or mmHg):

No data.



pH: 7.0SolutionAppearance and Odor:




Autoignition Pt: No data.


10.4

10.5

10.6

10.110.210.3


No data available.Conditions To Avoid:


strong acidsstrong oxidizing agents


carbon dioxidecarbon monoxidehydrogen chloride gasnitrogen oxides





Multi-region format

07/06/2016Revision:

Page: 5 of 6



11.1


Section 11. Toxicological InformationThe toxicological effects of this product have not been thoroughly studied.Information on

Toxicological Effects:

IARC ACGIH OSHA


25952-53-8 EDC {1-(3-(Dimethylamino)propyl)-3-ethyl-carbodiimidehydrochloride; EDAP; WSC}

n.a. n.a. n.a. n.a.

7732-18-5 Water n.a. n.a. n.a. n.a.

12.1

12.2

12.3

12.4

12.5


Toxicity:










Not dangerous goods.DOT Proper Shipping Name:DOT Hazard Class:UN/NA Number:


Not dangerous goods.ADR/RID Shipping Name:


UN Number:Hazard Class:

Not dangerous goods.ICAO/IATA Shipping Name:


Transport in accordance with local, state, and federal regulations.Additional TransportInformation:



S. 302 (EHS) S. 304 RQ S. 313 (TRI)


25952-53-8 EDC{1-(3-(Dimethylamino)propyl)-3-ethyl-carbodiimidehydrochloride; EDAP; WSC}

No No No

7732-18-5 Water No No No

Multi-region format

07/06/2016Revision:

Page: 6 of 6



CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists 25952-53-8 EDC

{1-(3-(Dimethylamino)propyl)-3-ethyl-carbodiimidehydrochloride; EDAP; WSC}

CAA HAP,ODC: No; CWA NPDES: No; TSCA: Yes -Inventory; CA PROP.65: No

7732-18-5 Water CAA HAP,ODC: No; CWA NPDES: No; TSCA: Yes -Inventory; CA PROP.65: No

This SDS was prepared in accordance with 29 CFR 1910.1200 and Regulation (EC)No.1272/2008.

Regulatory InformationStatement:






Multi-region format

07/06/2016Revision:

Page: 1 of 7

Acetonitrile/DMF solutionSAFETY DATA SHEET





Acetonitrile/DMF solution Product Name:










Flammable Liquids, Category 2Acute Toxicity: Inhalation, Category 4Acute Toxicity: Skin, Category 4Serious Eye Damage/Eye Irritation, Category 2Toxic To Reproduction, Category 1B


H225: Highly flammable liquid and vapor.H332: Harmful if inhaled.H312: Harmful in contact with skin.H319: Causes serious eye irritation.H360: May damage fertility or the unborn child.

GHS Hazard Phrases:

2.2 Label Elements:


P210: Keep away from {heat/sparks/open flames/hot surfaces}. - No smoking.P280: Wear {protective gloves/protective clothing/eye protection/face protection}.P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.P362+364: Take off contaminated clothing and wash it before reuse.P264: Wash {hands} thoroughly after handling.P201: Obtain special instructions before use.P202: Do not handle until all safety precautions have been read and understood.P281: Use personal protective equipment as required.


P303+361+353: IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin withGHS Response Phrases:

Multi-region format

07/06/2016Revision:

Page: 2 of 7


01/14/2015Supersedes Revision:water/shower.P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.P312: Call a {POISON CENTER/doctor/...} if you feel unwell.P302+352: IF ON SKIN: Wash with plenty of soap and water.P321: Specific treatment {see ... on this label}.P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easyto do. Continue rinsing.P337+313: If eye irritation persists, get medical advice/attention.P308+313: IF exposed or concerned: Get medical attention/advice.


2.3 Can cause fatal cyanide poisoning.Causes serious eye irritation.Harmful if inhaled or absorbed through the skin.Material may be irritating to the mucous membranes and upper respiratory tract.May be harmfull if swallowed.May cause skin or respiratory system irritation.May damage fertility or the unborn child.Several hours may elapse from exposure to onset of symptoms.To the best of our knowledge, the toxicological properties have not been thoroughly investigated.


CAS # /RTECS #




68-12-2LQ2100000

N,N-Dimethylformamide 20.0 % 200-679-5 616-001-00-X

Acute Tox.(D) 4: H312Eye Damage 2: H319Acute Tox.(I) 4: H332Toxic Repro. 1B: H360Flam. Liq. 3: H226

75-05-8AL7700000

Acetonitrile 80.0 % 200-835-2 608-001-00-3


Multi-region format

07/06/2016Revision:

Page: 3 of 7



4.2


Exposure may cause: asphyxia, cyanosis, depression, diarrhea, dizziness, drowsiness, excitement,headache, impaired judgement, lack of coordination, nausea, rash, vomiting, stupor, death.May cause liver damage, enlarged liver, high blood pressure, and flushing of face.May cause nausea, vomiting, diarrhea, and abdominal pain.Prolonged or repeated skin contact may cause dermatitis.Treat as cyanide poisoning. Always have on hand a cyanide first-aid kit, together with properinstructions. The onset of symptoms is generally delayed pending conversion to cyanide.










4.1



5.1

5.2


Flash Pt: No data.

As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved orequivalent), and full protective gear to prevent contact with skin and eyes.Note: Flammable acetonitrile and DMF








5.3

No data available.

Multi-region format

07/06/2016Revision:

Page: 4 of 7



6.3

6.1

6.2







7.1

7.2









TWA: 30 mg/m3 (10 ppm) 68-12-2 N,N-Dimethylformamide No data.





PEL: 10 ppm TLV: 10 ppm 68-12-2 N,N-Dimethylformamide No data.


8.2.1







No data available.



Multi-region format

07/06/2016Revision:

Page: 5 of 7







No data.









10.4

10.5

10.6

10.110.210.3




acidsalkali metalsalkyl aluminumsbasescarbon tetrachlorideinorganic nitratesoxidizing agentsreducing agentsstrong oxidizing agents







Multi-region format

07/06/2016Revision:

Page: 6 of 7



11.1


Section 11. Toxicological InformationThe toxicological effects of this product have not been thoroughly studied.Acetonitrile - Toxicity Data: Oral LD50 (rat): 2,460 mg/kg; Oral LD50 (mouse): 269 mg/kg; OralLD50 (rabbit): 50 mg/kg; Oral TDLO (man): 64 mg/kg; Skin LD50 (rabbit): 980 mg/kg; InhalationTCLO (human): 160 ppm (4h); Inhalation LC50 (rat): 7,551 ppm (8h);Acetonitrile - Irritation Data: Skin (rabbit) 500 mg mild; Eye (rabbit): 100 µl (24 hr) moderate;DMF - Toxicity Data: Oral LD50 (mouse): 2,900 mg/kg; Oral LD50 (rat): 2,000 mg/kg; Oral LD50(rabbit): 5,000 mg/kg; Skin LD50 (rat): >3,200 mg/kg; Skin LD50 (rabbit): 4,720 mg/kg;


Acetonitrile - Investigated as a mutagen, reproductive effector, and tumorigen.DMF - Investigated as a tumorigen, mutagen, and reproductive effector.Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here.See actual entry in RTECS for complete information.Acetonitrile RTECS Number: AL7700000DMF RTECS Number: LQ2100000


IARC: Group 3: Not classifiable as to its carcinogenicity to humans (DMF)Carcinogenicity/OtherInformation:

IARC ACGIH OSHA


68-12-2 N,N-Dimethylformamide n.a. 3 A4 n.a.


12.1

12.2

12.3

12.4

12.5


Toxicity:










Flammable liquid, n.o.s. (acetonitrile, dimethylformamide)DOT Proper Shipping Name:3 FLAMMABLE LIQUIDDOT Hazard Class:1993UN/NA Number: IIPacking Group:


Multi-region format

07/06/2016Revision:

Page: 7 of 7



Flammable liquid, n.o.s. (acetonitrile, dimethylformamide)ADR/RID Shipping Name:



Flammable liquid, n.o.s. (acetonitrile, dimethylformamide)ICAO/IATA Shipping Name:







S. 302 (EHS) S. 304 RQ S. 313 (TRI)


68-12-2 N,N-Dimethylformamide No Yes 100 LB Yes


CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists 68-12-2 N,N-Dimethylformamide CAA HAP,ODC: HAP; CWA NPDES: No; TSCA: Yes -

Inventory, 8D TERM; CA PROP.65: No









Multi-region format

07/06/2016Revision:

Page: 1 of 5

Autosampler Vial Inserts (200 µl)SAFETY DATA SHEET




Autosampler Vial Inserts (200 µl) Product Name:









Section 2. Hazards Identification2.1 Classification of the Substance or Mixture:

Based on evaluation of currently available data this substance or mixture is not classifiable according to GHS.GHS Hazard Phrases:

2.2 Label Elements:

NoneGHS Signal Word:

No phrases apply.GHS Precaution Phrases:

No phrases apply.GHS Response Phrases:


2.3 Material may be irritating to the mucous membranes and upper respiratory tract.May be harmful by inhalation, ingestion, or skin absorption.May cause eye, skin, or respiratory system irritation.To the best of our knowledge, the toxicological properties have not been thoroughly investigated.


CAS # /RTECS #




NANA

Autosampler Vial Inserts 100.0 % NA NA

No data available.

Multi-region format

07/06/2016Revision:

Page: 2 of 5











4.1

5.1

5.2


Flash Pt: No data.

As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved orequivalent), and full protective gear to prevent contact with skin and eyes.






No data available.Flammable Properties andHazards:

5.3

No data available.

6.3

6.1

6.2




Avoid raising and breathing dust, and provide adequate ventilation.As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or respirator,and appropriate personal protection (rubber boots, safety goggles, and heavy rubber gloves).



7.1

7.2

Section 7. Handling and StorageAvoid breathing dust/fume/gas/mist/vapours/spray.Avoid prolonged or repeated exposure.


Keep container tightly closed.Store in accordance with information listed on the product insert.





No data. No data. NA Autosampler Vial Inserts No data.

Multi-region format

07/06/2016Revision:

Page: 3 of 5



No data. No data. NA Autosampler Vial Inserts No data.

8.2.1





Do not take internally.Facilities storing or utilizing this material should be equipped with an eyewash and a safety shower.Wash thoroughly after handling.


No data available.




Physical States: [ ] Gas [ ] Liquid [ X ] Solid



No data.



autosampler vial inserts (200 µl)Appearance and Odor:






10.4

10.5

10.6

10.110.210.3


No data available.Conditions To Avoid:


No data available.Incompatibility - MaterialsTo Avoid:

No data available.HazardousDecomposition orByproducts:




Multi-region format

07/06/2016Revision:

Page: 4 of 5


11.1


Section 11. Toxicological InformationThe toxicological effects of this product have not been thoroughly studied.Information on

Toxicological Effects:

IARC ACGIH OSHA

NA Autosampler Vial Inserts n.a. n.a. n.a. n.a.

12.1

12.2

12.3

12.4

12.5


Toxicity:










Not dangerous goods.DOT Proper Shipping Name:DOT Hazard Class:UN/NA Number:


Not dangerous goods.ADR/RID Shipping Name:


UN Number:Hazard Class:

Not dangerous goods.ICAO/IATA Shipping Name:


Transport in accordance with local, state, and federal regulations.Additional TransportInformation:



S. 302 (EHS) S. 304 RQ S. 313 (TRI)


NA Autosampler Vial Inserts No No No

CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists NA Autosampler Vial Inserts CAA HAP,ODC: No; CWA NPDES: No; TSCA: No; CA

PROP.65: No

Multi-region format

07/06/2016Revision:

Page: 5 of 5









Multi-region format

Date post:	03-Feb-2021
Category:	Documents
Upload:	others
View:	2 times
Download:	0 times

SAFETY DATA SHEET Page: 1 of 6 AMP+ Derivatizing Reagent … · 2016. 7. 6. · Revision:...

Documents