Sample Quiz 6

8/2/2019 Sample Quiz 6

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Quiz-6 covers:

"pages 74 - 85[from Vasopressor Sympathomimetics

till end of Sympatholytics]

Each quiz will contain:

5 True/False/I am not sure questions+

5 Matching questions.

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Mark the following statements

as True (A) or False (B) or I

am not sure (C)

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Phenylephrine is a selective alpha-1agonist.

Phenylephrine produces generalized V.C.

Phenylephrine eye drops produces activemydriasis.

Phenylephrine produces hypertension withreflex bradycardia.

Phenylephrine produces hypotension withreflex tach cardia.4


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Phenylephrine is a selective -2 agonist.

Nasal decongestants act by blocking -2receptors.

Common adverse effect of nasal

decongestant is rebound congestion afterstopping the drug.

Advantages of recent members of Nasal

decongestants are: short duration of actionand less rebound congestion.

Advantages of recent members of Nasal

decongestants are: long duration of action5


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Naphazoline produces V.D. of mucousmembrane blood vessels.

Naphazoline is a nasal decongestant.

Naphazoline produces V.C. of mucousmembrane blood vessels.

Xylometazoline is an old nasal decongestant.

Tetrahydrozoline is used as nasaldecongestant.

Nasal decongestants are contraindicated in

hypertensive & anginal patients.6


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Vasodilators are used in treatment ofperipheral vascular disease.

Isoxsuprine produces skeletal muscle V.D.

Isoxsuprine produces skeletal muscle V.C.

Isoxsuprine produces smooth muscle V.D.

Salmeterol is a long acting selective -2

agonist.7


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Salbutamol is used as a nasaldecongestant.

Salbutamol and terbutaline are short

acting bronchodilators.

Bambuterol is given by inhalation in long

term prophylaxis of bronchial asthma.

Selective -2 agonists can produce

tachycardia as a side effect.8


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There is no drug with 100% selectivity.

Ritodrine contract the cervix duringlabour.

Ritodrine relaxes the uterus and cervixduring labour.

Ritodrine is used as a tocolytic agent inpremature labor.

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Alpha-blockers reverse pressor effect ofnoradrenaline on BP.

Alpha-blockers block pressor effect ofnoradrenaline on BP.

Alpha-blockers reverse the pressor effect ofadrenaline on BP.

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Postural hypotension is a prominent adverseeffect of-1 blockers.

Phentolamine is an -blocker with histaminelike action.

Phentolamine is used in diagnosis andtreatment of pheochromocytoma.

Phenoxybenzamine is a competitive -

blocker.

Phenoxybenzamine is a reversiblecompetitive -blocker.

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Phenoxybenzamine is a non-competitiveirreversible -blocker.

Phenoxybenzamine is used in treatment ofcardiogenic shock.

Phenoxybenzamine is used in treatment ofhemorrhagic and endotoxic shock.

Prazosin produces vasodilatation throughblocking post synaptic alpha 1 receptoronly.

Prazosin produces direct vasodilator effect.12


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Prazosin produces marked tachycardia asa side effect.

Therapeutic doses of prazosin producesminimal changes in heart rate.

Prazosin decreases both pre- and after-loads on the heart.

Prazosin is useful in hypertensive patientswith benign prostatic hyperplasia.

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Prazosin produces an initial hypertensiveeffect.

Prazosin is started by large dose in themorning.

Prazosin is started by small dose atbedtime.

Trimazosin is better than Prazosin as itdoes not show the first dosephenomenon.14


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Tamsulosin is a long acting -1 blocker used inttt of BPH.

Tamsulosin is a selective -1A blocker.

Yohimbine is a selective -1 blocker.

Yohimbine is an aphrodisiac drug.

Sildenafil (Viagra) increases cGMP through

blocking action of 5-phosphodiesterase15


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Propranolol and Metoprolol can pass BBB.

Nadolol and Atenolol are eliminated by thekidney.

Propranolol is hypophilic while atenolol isLipophilic.

Propranolol is a vasodilator -blocker.

Propranolol depresses all cardiacro erties.

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Propranolol reverses the hypertensive effect ofadrenaline.

Propranolol blocks the hypotensive effect ofisoprenaline.

Propranolol lowers blood pressure by its directVD effect.

Propranolol antagonizes the hypoglycemiceffect of insulin.

Hyperkalemia is an adverse effect of18


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Propranolol produces an initial decreasefollowed by prolonged increase in

peripheral resistance.

Propranolol treats angina by producing

coronary VD.

Propranolol is useful in treatment of Variant

angina.

Propranolol is a suitable antihypertensive inpatients with bronchial asthma.19


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Sedation and bronchospasm are majoradverse effects of atenolol.

Atenolol decreases all cardiac properties.

Atenolol and nadolol undergo first passextensive hepatic metabolism.

Nadolol produces sedation more thanpropranolol.20


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Oxprenolol has ISA.

Oxprenolol is safer than propranolol inpatients with supersensitive receptors.

Carvedilol can be used in some cases ofmoderate heart failure.

Carvedilol, a vasodilator -blocker, has anadditional anti-oxidant action.

Carvedilol and labetalol have combined B-blocker plus 1- blocker effects.

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Vasodilators -blockers include celiprolol,nebivolol, Carvedilol and labetalol.

Rebound hypertension occurs if-blockersare stopped suddenly.

Angina and even myocardial infarction canoccur if -blockers are stopped suddenly.

Patients are advised to stop -blockerssuddenly.

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-blockers are absolutely contraindicated inheart failure.

Postural hypotension is a serious adverseeffect of-blockers.

-blockers are contraindicated inglaucoma.

Celiprolol and nebivolol are partial agonists.23


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Labetalol has both and blocking activities.

Labetalol is used safely as antihypertensiveduring pregnancy.

Labetalol is useful in treatment ofpheochromocytoma.

Beta blockers are used alone in treatment ofpheochromocytoma.

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Guanethidine is a centrally acting sympatheticdepressant.

Guanfacine is a centrally acting sympatheticdepressant.

Sedation and Parkinsonism are adverse effects ofguanethidine.

Sedation and Parkinsonism are adverse effects ofreserpine.

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Reserpine and guanethidine are in commonuse nowadays in treatment of hypertension.

Reserpine depletes central and peripheralcatecholamines.

Rilmenidine is a selective imidazoline I-1agonist.

Methyldopa is considered as a prodrug.

Methyldopa acts as false transmitter.

Methyldopa stimulates directly the -2

receptors.26


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Methyldopa is suitable for treatment ofhypertension during pregnancy.

Methyldopa leads to a decrease in reninrelease by the kidney.

Methyldopa may produce +ve Coombstest.

Clonidine is an -2 blocker.

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Sudden stop of clonidine therapy results intorebound hypertension.

Clonidine when combined with morphine incaudal anesthesia provides better anesthesia.

Rebound hypertension occurs after abruptwithdrawal of : clonidine, methyl dopa, beta-blockers.

Guanfacine produces less rebound hypertension

than clonidine.28


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Matching Questions

* For the following matching questions, choosethe most appropriate ONE option for each

statement, each option may be chosen once ormore or not at all.

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a- Prazosin b- Phenoxybenzamine c-


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a- Prazosin b- Phenoxybenzamine c-Atenolol

d- Propranolol e- Carvedilolf- Reserpine

g- Methyldopa h- Ritodrine i-Guanfacine

J- phenylephrine

1- Vasodilator - blocker.2- Irreversible non-competitive -blocker.

3- Acts by formation of a false transmitter.

4- Depletes central and peripheral catecholamines.

5- Selective -1 blocker.6- -blocker that produces cold extremities.

7- Non-selective -blocker.

8- Useful in hypertension during pregnancy.

9- A cardio-selective -1 blocker.31

a- Pindolol b- Yohimbine c- Bisoprolol


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a- Pindolol b- Yohimbine c- Bisoprolol

d- Propranolol e- Prazosinf- Clonidine

g- Methyldopa h- Guanethidine

i- ReserpineJ- Ritodrine

1- Non-selective - blocker with ISA.

2- A selective -1 blocker.

3- Cardio-selective -1 blocker.

4- Direct -2 agonist.

5- Depletes central and peripheral catecholamines.

6- A selective -2 blocker.

7- Non-selective - blocker without ISA.

8- Indirect -2 agonist.

9- Is an adrenergic neuron blocker causing severepostural hypotension.

10- Used in hypertension with pregnancy.32

a- Phentolamine b- Tamsulosin


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a Phentolamine b Tamsulosinc- labetalol

d- Celiprolol e- Carvedilolf- Reserpine

g- Yohimbine h- Methyldopai- Guanfacine

J- Tetrahydrazoline

1- Non selective - blocker.

2- A selective -1A blocker.

3- An -2 blocker.

4- May produce +ve Coombs test.

5- Vasodilator blocker with additional antioxidant

action.

6- Like clonidine but produces less reboundhypertension.

7- Increase the sexual desire.

8- Partial agonist on b2 receptor.33


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