THE NEXT GENERATION IN CLINICAL RESEARCH

Q12015

Sanguine is bridging the gap

between patients and pharmas in the clinical R&D process by developing a novel @home clinical trial

platform that increases efficiency, transparency and big data collection.

Our platform leverages advancements in the shared economy and mobile / digital health

to deliver medical staff at the bedside in > 20 cities the US and serve 25 of the global pharmas.

INTRODUCTION TO SANGUINE

ResearchKit

ABOUT SANGUINE

Established in 2010 to serve the global clinical research market

> 300 pharmaceutical studies completed; > 5,000 study volunteer inquiries;> 2,000 applications for medical staff

Partnered with Mayo for biospecimen processing and testing, and invested in seed round

Experience working with the 20 largest pharmaceutical & biotechnology companies worldwide

our achievements

TRANSFORMATION OF CLINICAL RESEARCHvertical to horizontal industry shift

THE OLD VERTICAL CLINICAL RESEARCH INDUSTRY THE NEW HORIZONTAL CLINICAL RESEARCH INDUSTRY

OPEN APIs

SMARTPHONES/ WEARABLES

CLOSED SYSTEMS

AT-HOME TESTING ACADEMIC CLOSED

PRIVATE

SHARED ECONOMY

MEDICAL OFFICES / HOSPITALS

PATIENTSELF REPORT

MEDICAL RECORDS

NONPROFITS / PATIENT ADVOCACY

SOCIAL MEDIA MDs

TECHNOLOGY

LAB SERVICES

OPERATIONS

DATA REQUIREMENT

PATIENT RECRUITMENT

TECHNOLOGY

LAB SERVICES

OPERATIONS

DATA REQUIREMENT

PATIENT RECRUITMENT

QUINTILESPAREXEL

PPDICON

TRANSFORMATION OF CLINICAL RESEARCHcompanies by category

AT-HOME TESTING

TECHNOLOGY

LAB SERVICES

OPERATIONS

DATA REQUIREMENT

PATIENT RECRUITMENT

SANGUINE BUSINESS MODELproviding clinical research services

PROJECT DESIGNCONSULTATION

PATIENTRECRUITMENT

KIT PRODUCTION

MOBILE STAFFDEPLOYMENT

@HOME BIOSPECIMENCOLLECTION

PATIENTMONITORING

SEQUENCING,TESTING

PHARMAREQUESTS PROJECT

START Researchers request specific studies from Sanguine

Sanguine recruits patients for the study via social web and NPO partnerships

Sanguine's platform alerts Nurses on system to schedule blood draws at patient’s home

Mayo Clinic Bioservices performs testing, DNA sequencing, and other services using blood from the Nurses

AUTOMATED PLATFORM & ECOSYSTEM collecting biological and clinical data faster than ever before

PATIENT

PHARMA

MEDICAL STAFF

Sanguine has developed a disruptive, scalable platform serving the clinical research market through @home health services

Platform enables seamless communication and operations between pharma, patients, and medical staff

Significantly reduces time and cost for researchers to collect biological data

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FASTER COLLECTIONStudy enrollment through self-scheduler results in

faster collection.

TIME POINT STUDIESSafety, tolerability, or PK/PD

studies could benefit from more time points.

LONGITUDINAL DRAWSPost study surveillance or

longitudinal draws could be easily administered using at-

home service.

VALUE PROPOSITIONfaster collection, time point studies, longitudinal draws

TECHNOLOGY SOLUTIONS

RESEARCHER PORTAL MOBILE PHLEBOTOMY APPPATIENT PORTALSORP SangrePatient Portal

increasing effectiveness and efficiency

• Custom questionnaires

• Patient reported outcomes

• Rating Scales

• Co-Morbidities

• Treatment Efficacy

• Adverse Events

• Medical Record Summaries

• Clinical Testing

PARTICIPANT DATAobtain essential study information

greater access through diverse recruiting methods

• Blogs• Social media• Patient forums• Support groups

• Donor referrals to friends & family• Online advertisements• Non-Profit partnerships

PATIENT PORTAL

STUDY DASHBOARDView the status of all studies &

receive automatic notifications by email.

VISIT SCHEDULE & SAMPLE INFORMATION

Choose visit dates & sample quantity. Access upcoming schedule & sample

information.

RESEARCHER PORTALstay informed and updated

MOBILE PHLEBOTOMY APPaccess to major metropolitan cities around the nation

SANGREPhlebotomists receives draw information via Sangre (same day delivery, patient information, etc.)

40+ Cities Across

America

CASE STUDIESfulfill needs with unique study designs

Multiple Time Point Biospecimen Collections

Event-Based Biomarker Monitoring

Disease Interception Studies

01

02

03

MULTIPLE TIMEPOINTS BIOSPECIMEN COLLECTION

COHORT SELECTION40 donors collected at 3 time points, exclusions based on

medication & disease activity

PARTNERSHIP LAUNCHWorking with a sickle cell non-profit

organization, over 100 potential participants were identified in just 4

weeks

COMPLETIONAll 120 draws finished in 10 weeks!

STUDYLAUNCHED

STUDYCOMPLETED(10 WEEKS)

5 WEEKS

100 participantsrecruited

partnered with sickle cell non-profit

leveraging patient advocacy partners

SITE SUPPORTReduces site-work effort and

assist PI in performing monitoring and specimen

collection services

EVENT-BASED MONITORINGSanguine will implement patient monitoring tools to alert mobile staff when patients need to be

visited and specimens collected

AT-HOME PROCEDURESIncrease retention and study visit

compliance by going directly to patient's homes to conduct biweekly study

procedures

EVENT-BASED BIOMARKER MONITORINGremote site monitoring

PARTICIPANT RECRUITINGPatients can be selected based on

disease history, propensity for developing a disease or experiencing

certain symptoms

MONITORINGParticipants will be followed over

several months or years to observe how their disease progresses

COHORT SELECTION

DISEASE INTERCEPTION STUDY

LONGITUDINALASSESSMENT

TRIAL ENROLLMENT

RANDOMIZATIONSelected participants will be sent to the

clinical site for physician visit and enrollment into clinical trial

natural history study