Scientific abstract sessions

J ALLERGY CLIN IMMUNOL A b s t r a c t s $ 3 5 5 VOLUME 111, NUMBER 2

Scientific Abstract Sessions

Immunotherapy 1 2

Poster Session 2501

Saturday, March 8 11:15 AM to 12:15 PM

Withdrawn Levels of Natural Antibodies to Endotoxin in Bronchial Asthma Patients Undergoing Allergen Specific Immunotherapy (SIT) V. A. Beioglazov l, A. I. Gordienko I, A. A. Bakova I, L. N. Zna- menskaya I, A. V. Rozovenko I, L. M. Du Buske2; JThe Crimean State Medical University, Simferopol, UKRAINE, 2Immunology Research Institute of New England, Fitchburg, MA.

3 Expression of Scavenger Receptors on Peripheral Blood Mono- cytes in Asthma Patients During Specific Immunotherapy (SIT) K. KowalJ, L. M. Du Buske 2, A. Bodzenta-Lukaszykl; IUniversi- ty Medical School of Bialystok, Bialystok, POLAND, 2Immunolo- gy Research Institute of New England, Fitchburg, MA.

4 Long-Term Immunologic Effects ofAeroallergen Immunotherapy K. C. Brown, R. A. Wood, R. G. Hamilton, P. A. Eggieston, N. E Adkinson, Jr.; Johns Hopkins University, Baltimore, MD.

5 The Effect of Mite Allergen lmmunotherapy on Nasal Nitric Oxide in Allergic Adults M. J. Lanz, M. Barzaga, M. A. Lanz; AAADRS Clinical Research Center, Coral Gables, FL.

6 Allergen Immunotherapy in HIV Patients with Severe Allergic Rhinitis A. Kohli I, M. Lee-Wong2; ISection of Allergy and Clinical Immunology, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, 2Division of Clinical Immunology and Allergy, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY.

7 Long-Lasting Efficacy of Sublingual Immunotherapy in Children G. Passalacqua j, V. Di Rienzo 2, E Marcucci 3, P. Puccinelli 4, S. Parmiani 4, E Frati 3, L. Sensi 3, G. W. CanonicaJ; 1Department of Internal Medicine, Genoa University Allergy & Resp. Diseases, Genova, ITALY, 2Clinica Villa Benedetta, Roma, ITALY, 3Chil- dren's Hospital University of Perugia, Perugia, ITALY, 4Alk-Abel- 16, Lainate, Milano, ITALY.

8 Safety of Sublingual Immunotherapy in Children L. Blazowski ~, B. Rogala 2, L Gluck2; IPediatric & Allergology, General Hospital, Jaslo, POLAND, 2Internal Diseases, Allergology & Clinical Immunology, Silesian School of Medicine, Zabrze, POLAND.

9 Systemic Reactions Secondary to Allergen-Specific Immuno- therapy in a Population of Monterrey, Mexico D. J. L. Lopez; Allergy, University Hospital, Monterrey, Mexico, MEXICO.

Poster Session 2502


Rhinitis and Sinusitis 10 Cetirizine and Monte lukas t in the Prophylaxis of Allergic

Rhinitis (AR) Symptoms M. M. Kurowski, P. Kuna, P. Gorski; Pneumonology and Allergy, Medical University of Lodz, Lodz, POLAND.

11 A Compar ison of Fexofenadine/pseudoephedrine (F/P) and LoratadinefMontehikast (L/M) in the Treatment of Seasonal Allergic Rhinitis (SAR)

M. L. deTineo, R. Moinuddin, B. Maleckar, R. M. Naclerio, E M. Baroody; University of Chicago, Chicago, IL

12 Multiple Analyses, Multiple Populations, One Outcome: Lack of Effect of Fluticasone Propionate on Prepubescent Growth B. A. PriUaman, K. M. Kral; Biomedical Data Sciences, Statistics & Programming, GlaxoSmithKline, Inc, Research Triangle Park, NC.

13 Triamcinolone Acetonide and Fluticasone Propionate Aqueous Nasal Sprays Significantly Improve Nasal Airflow in Patients with Seasonal Allergic Rhinitis C. L. Gallet I , E. O. Meltzer t, A. A. Jalowayski ~, E M. Diener 2, Y. Liao 2, G. C. Georges2; IAIlergy and Asthma Medical Group and Research Center, San Diego, CA, 2Aventis Pharmaceuticals, Bridgewater, NJ.

14 Two-Week "I~eatment with Cetirizine 10 mg Is Associated with Increased Drowsiness Compared with Fexofenadine 180 mg L. E. Mansfield ~, S. Meeves 2, Y. Liao 2, G. Georges2; 1El Paso Institute for Medical Research and Development, El Paso, TX, 2Aventis Pharmaceuticals, Bridgewater, NJ.

15 Comparat ive Efficacy of Fexofenadine 180 mg vs Cetirizine 10 mg at the 24th Hour Post-dose G. N. Gross I , S. Meeves 2, Y. Liao 2, G. Georges2; IPharmaceutical Research & Consulting, lnc, Dallas, TX, 2Aventis Pharmaceuticals, Bridgewater, NJ.

16 INS37217 In t ranasa l , a P2Y 2 Receptor Agonist, Is a Novel Treatment for Allergic Rhinitis A. E. Schaberg l, E. O. Meltzer 2, C. E LaForce 3, D. S. Pearlman 4, J. C. Ice T, L. M, LaVange ~, D. J. KellermanJ; qnspire Pharmaceu- ticals, lnc, Durham, NC, 2Allergy and Asthma Medical Group and Research Center, San Diego, CA, 3North Carolina Clinical Research, Raleigh, NC, 4Clinical Research Centers of Colorado, Denver, CO.

17 Desloratadine: Safety and Tolerability Data in Clinical Practice U. H. J. Borehard ~, A. E Daly 2, A. Plenker3; llnstitute of Phar- macology & Clinical Pharmacology, Heinrich Heine University of Dtisseldorf, Dtisseldorf, GERMANY, 2Healthcare Dimensions, Dublin, IRELAND, 3Essex Pharma. Munich, GERMANY.

18 Autumnal Hay Fever: A Profile of the Disease in the Commu- nity and of the Attitudes Towards Its Causes and Management E. R. Tovey j, T. J. O'Meara 2, G. Morgan3; JDepartment of Medi- cine, University of Sydney, Camperdown, NSW, AUSTRALIA, 2Woolcock Institute of Medical Research, Camperdown, NSW, AUSTRALIA, 3Southern Cross Institute of Health Research, Lis- more, NSW, AUSTRALIA.

19 High-Resolution Rhinomanometry, a New Method to Evaluate Nasal Patency in Patients with Allergic Rhinitis K. Vogt j, A. A. Jalowayski 2, E. O. Meltzer 3, A. G. Harris4; JPrivate ENT Clinic, University of Halle, Halle, GERMANY, 2University of California, San Diego, La Jolla, CA, 3Allergy and Asthma Med- ical Group and Research Center, San Diego, CA, 4Schering- Plough, Kenilworth, NJ.

20 Results of a Phase II, Multiple-Dose, Randomized Trial of an Anti-CD23 Monoclonal Antibody (IDEC-152) in Patients with Seasonal Allergic Rhinitis T. B. Casale I , W. W. Busse 2, R. G. Lizambri 3, P. E. Korenblat 4, W. E Schoenwetter 5, J. M. Weiler 6, L. J. Rosenwasser 7, A. S. Nayak 8, R. M. Perea 3, M. C. Totoritis3; ICreighton University School of Medicine, Omaha, NE, 2UW Hospital and Clinics, Madison, WI, 3IDEC Pharmaceuticals Corporation, San Diego, CA, 4The Clini- cal Research Center, St. Louis, MO, 5park Nicollet Institute, Min- neapolis, MN, 6Iowa Clinical Research Corporation, Iowa City, IA,

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7National Jewish Medical and Research Center, Denver, CO, 8Sneeze, Wheeze, and Itch Associates, Normal, IL.

21 Specific Nasal Allergic Symptoms: Differentiation in Their Reduction by the Ocular Use of Ketotifen Fumarate 0.025% Ophthalmic Solution D. Dehning; Discover Vision Centers, Kansas City, MO.

22 Butterbur, a Herbal Remedy, Protects Against Allergen-Sensi- tized Mast Cell Priming in Seasonal Allergic Rhinitis I. J. Carstairs l, D. K. C. Lee 2, K. Haggart 2, C. M. Jackson 2, G. P. Currie 2, B. J. Lipworth2; IAsthma and Allergy Research Group, Dundee, UNITED KINGDOM, eAsthma and Allergy Research Group, Ninewells Hospital and Medical School, UNITED KING- DOM.

23 Large Particle Nebulized Saline Therapy for Chronic Nasal Obstruction: A Prospective Evaluation E. Khemici, M. Blaquiere; Centre Hospitalier de l'Universit6 de Montr6al, Montreal, PQ, CANADA.

24 Fexofenadine 180 mg and Cetirizine 10 mg Demonstrate a Sim- ilar Effect on Total Symptom Score R. F. Lockey 1, S. Meeves 2, Y. Liao 2, G. Georges2; t Department of Internal Medicine, University of South Florida College of Medi- cine/Division of Allergy & Clinical Immunology, Tampa, FL, 2Aventis Pharmaceuticals, Bridgewater, N J.

25 Effect of Once-Daily Desloratadine in Patients with Perennial Allergic Rhinitis (PAR): A Double-Blind, Placebo-Controlled Study K. T, Kim I, G. L. Sussman 2, J. Hebert 3, W. R. Lumry '~, B. Lutsky -s, D. GatesS; IWest Coast Clinical Trials, Long Beach, CA, 2Univer- sity of Toronto, Toronto, ON, CANADA, 3Centre de Recherche Applique en Allergic de Quebec, Quebec, PQ, CANADA, 4AARA Research Center, Dallas, TX, 5Schering Corp, Kenilworth, NJ.

26 Immunopathology of Chronic Rhinosinusitis in Young Children L. E. H. CoffinetL K. H. Chan 2, M. J. Abzug 3, E. A. E Simoes 4, C. Cool 5, A. H. Lin6; ~Service ORL (ENT), Hopital Central de Nancy (France), Nancy, FRANCE, 2Otolaryngology-Head and Neck Surgery, The Children's Hospital, Denver, CO, 3Pediatric Infectious Diseases, The Children's Hospital, Denver, CO, 4pedi- atric Infectious Diseases, The Children's Hospital, Denver, CO, 5pathology, University of Colorado School of Medicine, Denver, CO, 6Allergy/Immunology, National Jewish Medical and Research Center, Denver, CO.

27 Successful Culture of Human Airway Epithelial Cells in Air- Liquid Interface Using Cells from Nasal Scraping N. Lopez-Souza I , P. C. Avila 1, H. Choi 2, J. Widdicombe3; IMedi- cine, University of California San Francisco, San Francisco, CA, 2Children's Hospital of Oakland Research Institute, Oakland, CA, 3physiology, University of California Davis, Davis, CA.

28 A 4-Year-Old Girl with Chronic Sinusitis and Aplastic/ Hypoplastic Turbinates S. S. Aceves ~, H. M. Hoffrnan ~, J. E Bastian2; IAllergy/lmmunology, University of California, San Diego, La Jolla, CA, 2Allergy/ Immunology, Childrens Hospital, San Diego, San Diego, CA.

29 Antibodies to Staphylococcal Enterotoxins in Patients with Chronic Sinusitis/Nasal Polyposis M. M, Lowery ~, L. C. Grammer I, A. M. Ditto 1, K. Seiberling 2, R. C. Kern e, D. B. Conley 2, A. TripathiJ; ]Allergy/Immunology, Northwestern University, Chicago, IL, 2Otolaryngology, North- western University, Chicago, IL.

30 Synergistic Induction of TARC in Fibroblasts by IL-4 and LPS: Modulation by TGF-betal M. Nonaka. A. Fukumoto, R. Pawankar, N. Ogihara, A. Sakanushi, S. Yamagishi, T. Yagi; Nippon Medical School, Tokyo, JAPAN.

31 Fungus Culture Rate of Nasal Secretions in Allergic Rhinitis and Sinusitis Patients W, Kim I , M. Shon 2, G. Jang 2, K. Kim2; 1pediatrics, [nje Universi-

ty College of Medicine, Seoul, REPUBLIC OF KOREA. 2Pedi- atrics, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA.

32 IgG3 Subclass Deficiency in Chronic Sinusitis M. Pasha I , K. Bundy 2, A. Nellis 3. P. Feustel 4, J. Celestin I , C. Tep- per]; IDepartment of Medicine, Division of Allergy, Asthma, and Immunology, The Albany Medical College, Albany, NY, 2The Albany Medical College, Albany, NY, 3Department of Medicine, The Albany Medical College, Albany, NY, 4Center for Neurophar- macology, The Albany Medical College, Albany, NY.

33 The Role of Fungi in Chronic Sinusitis 3", Hofman, W, Skrobisz, A. M. Hofman; Center of Allergology, Poznan, POLAND.

34 Comparative In Vivo Bioactivity of Modern Hi-Antihistamines in Atopic Asthma C. E. Bates, D. K. C. Lee, G. P. Currie, B. J. Lipworth; Asthma and Allergy Research Group, Dundee, UNITED KINGDOM.

35 Systemic Bioactivity Profiles of Intranasai Triamcinolone and Mometasone in Patients with Perennial Allergic Rhinitis F. Robb, D. K. C. Lee, E. J. Sims, G. E Currie, L C. McFarlane, B. J. Lipwortb; Asthma and Allergy Research Group, Dundee, UNITED KINGDOM.

36 Aspirin (ASA) Hypersensitivity as a Risk Factor Responsible for the Development of Severe Asthma in Outpatients M. Kupczyk, 1. Kuprys, P. Kuna, P. G6rski; Department of Medi- cine Medical University of Lodz. Division of Pneumonology and Allergy, Lodz, POLAND.

3"l Once-Daily Budesonide Aqueous Nasal Spray (BANS) Does Not Suppress Hypothalamic-Pituitary-Adrenal (HPA) Axis Function in Children 2 to 5 Years of Age with Allergic Rhinitis K, T. Kim 1, T. Uryniak 2, B. Simpson 2, L. O'Dowd 2, E Casty2; 1Allergy, Asthma, Respiratory Care Medical Center, Long Beach, CA, 2AstraZeneca LP, Wilmington, DE.

38 Fexofenadine Effectively Relieves All Symptoms of Seasonal Allergic Rhinitis in Children Aged 6--11 Years I5. Wahn j, E. Meltzer 2, E Simons 3, D. Bernstein 4, J. van Bavel 5, H. Milgrom 6, E. Ruuth7; IDepartment of Pediatric and Pneumolo- gy and Immunology, University Children's Hospital, Berlin, GER- MANY, 2Allergy and Asthma Medical Group and Research Center, San Diego, CA, 3Department of Pediatrics and Child Health, Uni- versity of Manitoba, Winnipeg, MB, CANADA, 4Bernstein Clini- cal Research Centre, Cincinnati, OH, 5Allergy and Asthma Associ- ates, Austin, TX, 6National Jewish Medical and Research Centre. Denver, CO, 7Aventis Pharma, Romainville Cedex, FRANCE.

39 A Double-Bllnd Comparison of Fexofenadine 60 mg BID Ver- sus Loratadine 10 mg QD in Healthy Japanese Volunteers: Effect on Histamine-lnduced Wheal and Flare J. Boyle, E Ridout, R. Meadows, 1. Hindmarch: HPRU Medical Research Centre, Guildford, Surrey, UNITED KINGDOM.

40 Nasal Congestive Responses to Prostaglandin D2 (PGD2) are Enhanced in Rhinitic Subjects J. Leroux ], E. Khemici l, M. Haasz I, S. Sidhani I. M. Y. Desrosiers2; ICentre Hospitalier de l'Universit6 de Montr6al, Montreal, PQ, CANADA, eNasal Physiology Laboratory, Centre Hospitalier de l'Universit6 de Montrfal, Montreal, PQ, CANADA.

41 Desioratadine Treatment Improves Nasal Patency as Measured Objectively by High-Resolution Rhinomanometry in Patients with Seasonal Allergic Rhinitis A. A. Jalowayski I, E. O. Meltzer e, A. G. Harris3; IChemosensory Perception Laboratory, University of California, San Diego. La Jolla, CA, 2Allergy and Asthma Medical Group and Research Cen- ter, San Diego, CA. 3Schering-PIough, Kenilworth, NJ.

J ALLERGY CLIN IMMUNOL A b s t r a c t s S 3 5 7 VOLUME 111, NUMBER 2

42 Desloratadine Reduces Nasal Congestion and Other Signs and Symptoms of Allergic Rhinitis (AR) Induced by House Dust Mite (HDM) Allergen Exposure in the Vienna Challenge Chamber U. P. Stuebner f, E Horak l, R. Zieglmeyer ] , A. Kawina I , W. Engel- brecht I, M. MoserL A. G. Harris2; 1University of Vienna, Vienna, AUSTRIA, 2Schering-Plough Corp, Kenilworth, NJ.

43 Intranasal Exposure of Mice to House Dust Mite Elicits Allergic Airway Inflammation via a GM-CSF-Mediated Mechanism E. C. Cates, R. Fattouh, M. Jordana; Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, ON, CANADA.

44 Budesonide Aqueous Nasal Spray (BANS) Is Preferred Over Fluticasone Propionate Nasal Spray (FPNS) Based on Specific Sensory Attributes S. R. Shah I, C. Miller 2, N. Pethick 2, T. Uryniak 2, K. C. Jones 2, L. O'Dowd2; IAllergy and Asthma Consultants, Collegeville, PA, 2AstraZeneca LP, Wilmington, DE.

45 Clinical Trial of a Pollen Filter for Reducing Seasonal Rhinitis T. J. O 'Meara 1, J. K. Sercombe 1, G. Morgan 2, H. K. ReddelL W. Xuan 1, E. R. Tovey3; IWoolcock Institute of Medical Research, Camperdown, NSW, AUSTRALIA, 2Southern Cross Institute of Health Research, Lismore, NSW, AUSTRALIA, 3Medicine. Uni- versity of Sydney, Camperdown, NSW, AUSTRALIA.

46 Immunos t imula tory Sequence Oligodeoxynucleotides (ISS) Provide Allergen-Independent Protection from Allergic Rhinitis C. Rhee 1, L. Lebit 2, D. Chisholm 2, A. A. Horner 2, E. Raz2; 1Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, REPUB- LIC OF KOREA, 2Department of Medicine, UCSD School of Medicine, La Jolla, CA.

47 Dose-Ranging Study of Loteprednol Etabonate Nasal Spray (LE) as a Once-Daily Trea tment for Allergic Rhinit is in an Environmental Exposure Unit (EEU) N. Krug ] , H. Geldmacher I , D. Nguyen 2, M. Larbig ] , N. LaVallee 2, J. HohlfeldL U. Petzold 2, R. Hermann2; IFraunhofer Institute of Toxicology and Aerosol Research, Hannover, GERMANY, 2VIA- TRIS Clinical Development, Frankfurt, GERMANY.

48 Does Rhinltis Interfere with Bronchial Responsiveness (BR) to Methacholine (M) and Sensitization to Aeroallergens? I. C. Camelo-Nunes, G. F. Wandalsen, K. Melo, C. K. Naspitz, D. So16; Pediatrics/Allergy, Universidade Federal de Sao Paulo, S~o Paulo, BRAZIL.

49 Eicosanoid Mediators in Distinct Types of Rhinitis M. Swierczynska ], E. Nizankowska-Mogilnicka 1, P. Strek 2, A. Szczeklik ~; l Department of Medicine, Jagiellonian University School of Medicine, Cracow, POLAND, 2Department of Otolaryngology, Jagiellonian University School of Medicine, Cracow, POLAND.

50 Relationship Between Bioavailability of In t ranasal Corticos- teroids and Effects on Growth in Pediatric Patients E. E. Philpot, M. A. Faris, K. A. Rickard; GlaxoSmithKline, Research Triangle Park, NC.

Sl The Effects of Desloratadine (DL) on the Allergic Inflammatory Response of the Nasal Mucosa Associated with Seasonal Allergic Rhinitis (SAR): A Nasal Mucosal Biopsy Study (NMBX) D. P. Skoner 1, D. A. Gentile ], A. Gungor 2, S. N. Belenky ], B. L. Angelini ], H. M. RichardsL S. Hart 3, W. J. Doyle4; tAllergy/ Immunology, Children's Hospital of Pittsburgh, Pittsburgh, PA, 2Ent. Children's Hospital of Pittsburgh, Pittsburgh, PA, 3Genomic Science Center, University of Pittsburgh, Pittsburgh, PA, 4Ent. Uni- versity of Pittsburgh, Pittsburgh, PA.

52 A Meta-Analysis Assessing the Efficacy of Intranasal Corticos- teroids on Improving Nasal Congestion, Sleep Quality, and Daytime Somnolence in Perennial Allergic Rhinitis M. Ripchinskil, E Gurevich I, K. Hughes 1, S. Kakumanu L S. Teets i, E. Lehman 2, V. Chinchilli 2. T. J. Craig3; J Pennsylvania State Univer- sity, College of Medicine, Hershey, PA, 2Health Evaluation Sciences,

Pennsylvania State University, College of Medicine, Hershey, PA, 3Allergy, Asthma, and Pulmonary Research Laboratory, Pennsylvania State University, Hershey Medical Center, Hershey, PA.

53 Dynamics of Ai rborne Pollen Particles f rom Inhala t ion to Allergic Reaction in the Nose M. Okuda; Japan Allergy And Asthma Clinic, Tokyo, JAPAN.

54 Clinical Eff• of Omalizumab on Seasonal Allergic Rhinitis Associated with Japanese Cedar Pollen T. Ishikawa i, S. Ogino 2.3, T. Nagakura 4,5, K. Okubo6; JKumamo- to University, Kumamoto, JAPAN, 2Osaka Clinical Research Orga- nization for Medicaments Clinic, Osaka, JAPAN, 3Department of Adult and Geriatric Nursing, Osaka University School of Medi- cine, Osaka, JAPAN, 4Tokyo Clinical Research Organization for Medicaments Bldg. Clinic, Tokyo, JAPAN, 5yoga Allergy Clinic, Tokyo, JAPAN, 6Department of Otorhinolaryngology, Nippon Medical School, Tokyo, JAPAN.

55 Efficacy of Morning Dosing of Montelukast in Seasonal Aller- gic Rhinitis (SAR) G. Larkins I, J. van Adelsberg I, A. Pedinot~, G. Philip 1, T. E Reissi; IMerck & Co, Inc, Rahway, NJ, 2Princeton Center for Clin- ical Research, Princeton, NJ.

56 The Relationship Between Atopic Status and Nasal IL-10 Lev- els in Infants with RSV Bronchiolitis H. Chung j, S. Kim2; IPediatrics, School of Medicine, Catholic University of Taegu, Taegu, REPUBLIC OF KOREA, 2Clinical Pathology, School of Medicine, Catholic University of Taegu, Taegu, REPUBLIC OF KOREA.

57 Risk Factors for Rhinitis in Schoolchildren G. F. Wandaisen, I. C. Camelo-Nunes, C. K. Naspitz, D. So16; Pediatrics, Universidade Federal de S~o Paulo-UNIFESE S~o Paulo, BRAZIL.

58 Chronic Sinusitis and Intravenous Antibiotic Therapy: Resolu- tion, Recurrence, and Adverse Events K. C. Fowler, J. A. Duncavage, J. J. Murray, S. Tanner; Asthma Sinus Allergy Program, Vanderbilt University, Nashville, TN.

59 Intranasal Fluticasone Propionate Provided Greater Relief Com- pared to Oral Montelukast for Nasal Congestion and Other Day- time and Evening Nasal Symptoms of Seasonal Allergic Rhinitis B. G. Mart in 1, C. P. Andrews 2, J. H. van Bavel 3, E C. Hampel 4, E. E. Philpot 5, C. A. Baidoo 6, K. A. RickardS; 1Southwest Allergy and Asthma Research, San Antonio, TX, 2Lung Diagnostic, Ltd, San Antonio, TX, 3Allergy and Asthma Associates, Austin, TX, 4Cen- tral Texas Health Research, New Braunfels, TX, 5GlaxoSmithK- line, Research Triangle Park, NC, 6GlaxoSmithKline, Mississauga, ON, CANADA.

60 Study of Mold's Sensitization Prevalence in Patients with Aller- gic Rhinitis and/or Asthma J. Bartral,2; 1Allergy and Immunology, Hospital Universitari de Girona Dr. Josep Trueta, Girona, SPAIN, 2Workgroup of Societat Catalana All~rgia Immunologia Clfnica, Catalonia, SPAIN.

61 Desloratadine 5 mg Once Daily Significantly Improves Individ- ual and Total Symptoms Compared with Placebo in Patients with Seasonal Allergic Rhinitis E. O. Meltzer 1, A. G. Harris2; IAllergy and Asthma Medical Group and Research Center, San Diego, CA, 2Schering-Plough, Kenilworth, NJ.

62 A Possible Association Between Allergic Rhinit is (AR) and Attention Deficit Hyperactivity Disorder (ADHD) A. Brawley ], B. A. SilvermanL M. D. GuanzonL H. Bennett 2, A. T. Schneider1; IAllergy & Immunology, Long Island College Hos- pital, Brooklyn, NY, 2Long Island College Hospital, Brooklyn, NY.

63 Skin Testing (ST) Versus Radioal lergosorbent (RAST) for Indoor Allergens B. Chinoy, S. L. Bahna; Section of Allergy/Immunology, Louisiana State University Health Sciences Center, Shreveport, LA.

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Pos te r Sess ion 25O3


Immunomodulation 64 Low Dose of Daclizumab Decreases Mitogen-Induced T-Cell

Activation T. Tsao, J. Woo, M. McClellan, S. Keller, C. Klingbeil, V. Vexler; Preclinical Development, Protein Design Labs, Fremont, CA.

65 Protective Effects of a Bacterial Stimulus on IL-4 Receptor Expressing Cells in Allergen-Exposed Mice A. G. Alvarez, A. Joetham, C. Taube, A. Balhorn, A. Dakhama, E. W. Gelfand; Pediatrics, National Jewish Medical and Research Center, Denver, CO.

66 House Dust Mite (HDM) Peptide-Conjugated Immunostimula- tory DNA Induced a Strong Interferon- T Response on PBMCs of HDM-Sensitized Asthmatics J. Lee l, Y. Cho 2, S. Yoo3; lInternal Medicine, Kangdong Sacred Heart Hospital, Seoul, REPUBLIC OF KOREA, 2Microbiology, Eulji University Medical College, Daejeon, REPUBLIC OF KOREA, 3Microbiology, Eulji University Medical College, Dae- icon, REPUBLIC OF KOREA.

6"7 Kinetics and Mode of Peptide Delivery via the Respiratory Mucosa Determine the Outcome of Th2 Immunity Versus Tol- erance in Allergic Inflammation of the Airways E. R. Jarman; Biology Research, ALK-AbelIo A/S, Hoersholm, DENMARK.

68 Co-injection of DNA Encoding T-Cell Epitope on the Der p and BCG Inhibited Allergic Responses in Mice S. S. Kwon% S. Y. Lee% S. J. Kim% Y. K. Kim 1, K. H. Kim% H. S. Moon I , J. S. Song/, T. Yoo 2, S. H. Parkl; qntemal Medicine, Catholic University of Korea, Medical College, Seoul, REPUBLIC OF KOREA, 2Internal Medicine, University of Tennessee, Memphis, TN.

69 Modulation of the IgE Response to Alternaria After DNA Vac- cination with the Major Alternaria Allergens (r Alt al and r Alt a2) in a Brown Norway Rat Model M. M. Montalbano 1, H. Sanchez 2, E. L. Keyes 2, L. A. Rosenthal 3, R. L. Sorkness 4, R. K. Bush3; IMedicine, Allergy/Immunology Section, University of Wisconsin Medical School, Madison, W1, 2Research, William S. Middleton VA Medical Center, Madison, WI, 3Medicine, University of Wisconsin Medical School, Madison, WI, 4University of Wisconsin-Madison, School of Pharmacy, Madison, WI.

70 Polycional IgM as an Inhibitor of CH50 Complement Activity N. Mathur% P. M. Mueller 2, H. P. Drew 1, M. Nowakowski 3, R Joksl; IAllergy/Immunology, SUNY-Downstate Medical Center, Brooklyn, NY, 2Medicine/Rheumatology, SUNY-Downstate Med- ical Center, Brooklyn, NY, 3Pathology/Medicine, SUNY-Down- state Medical Center, Brooklyn, NY.

71 3" Hexameric Deoxyguanosine Run (dG 6 Run) Enhances Immunogenecity of Phosphodiester CpG-ODN Without Increas- ing the Risk of Splenomegaly in Murine Model of Asthma Y. ChangL2, T. Kim l, H. Kang% S. Kim 2, J. BahnL2, y. Kiml,2, K. MinL2, y. Kiml.2, S. Cho],2; qntemal Medicine, Seoul National Uni- versity College of Medicine, Seoul, REPUBLIC OF KOREA, 2The Institute of Allergy and Clinical Immunology, Seoul National Uni- versity Medical Research Center, Seoul, REPUBLIC OF KOREA.

72 Identification and Development of a Small Molecule Com- pound Effective in Suppressing Early Mediators of Allergy M. L. Richards, S. C. Cruz, H. Banie, K. Tieu, J. C. Sircar; AVANIR Pharmaceuticals, San Diego, CA.

73 Review of the Evidence for the Modulation of the Allergic Inflammatory Cascade by the Ht-Antagonist Desloratadine G. D. Marshall, Jr.; Division of Allergy & Clinical Immunology, University of Texas Houston Health Science Center, Houston, TX.

74 Detection of Der p 1 and Der p 2 in Enzymatically Inactive Extracts of Dermatophagoides Pteronyssinns J. Carn6s, M. Gallego, E Marafi6n, V. Iraola, E. Fernandez-Cal- das; R&D, CBF LETI Laboratories, Tres Cantos (Madrid), SPAIN.

75 Anaphylaxis by Cyancobalamin--A Case Report S. Khan, I. Muhammad, E K. M. Nawaiz; Allergy, Immunology, A1-Junaid Hospital, Nowshera, PAKISTAN.

76 Modulation of Allergic Conjunctivitis with a DNA Vaccine to Recombinant Alt a 2 in an Animal Model of Alternaria Sensitivity M. McGeehan% H. Sanchez 2, E. L. Keyes 2, N. P. Barney 3, R. K. Bush4; t Department of Medicine, University of Wisconsin-Madi- son, Madison, WI, 2Research, VA Hospital, Madison, WI, 3Oph- thomology, University of Wisconsin, Madison, WI, 4Medicine, University of Wisconsin, Madison, WI.

Pos te r Sess ion 2504


Aerobiology of Pollens and Molds 77 Patterns of Prick Skin Test Reactivity to Tree Pollen Allergens

in Patients with Seasonal Allergic Rhinitis Are Unrelated to Measured Pollen Exposure J. F. White% D. I. Bernstein 2, M. Villareal 2, H. St. Clair 3, K. Mur- phy2; qmmunology, University of Cincinnati, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH, 3Department of Envi- ronmental Services, Cincinnati, OH.

78 Assessing Allergenicity of Indoor Air Fungal Contaminants M. D. W. Ward/, M. E. Viana 2, N. Haykal-Coates% L. B. Copeland% S. H. Gavet0, M. K. Selgrade~; tExperimental Toxi- cology Division, US Environmental Protection Agency, Research Triangle Park, NC, 2College of Veterinary Medicine, North Caroli- na State University, Raleigh, NC.

79 Classification of Asteraceae Weed Pollen Grains by Image Analysis T. C. Ong, X. Wang, B. W. Lee, H. T. W. Tan, E T. Chew; Nation- al University of Singapore, Singapore, SINGAPORE.

80 Identification of an Unknown Prevalent Fungal Airspora Com- ponent in Singapore via Internal Transcribed Spacer (ITS) and 18S rDNA Sequences S. S. Joshi, T. C. Ong, A. H. B. Loo, E L. Wong, T. K. Tan, E T. Chew; National University of Singapore, Singapore, SINGAPORE.

81 Classification of Airspora Using Support Vector Machines (SVM) S. Kumar, S. H. Ong, S. Ranganath, T. C. Ong, F. T. Chew; National University of Singapore, Singapore, SINGAPORE.

82 Leaf Surface Fungi as Aeroallergens K. Dorsey, E. Levetin; Biological Science, University of Tulsa, Tulsa, OK.

83 A Comparison of Counting Methods for Hourly Airborne Spore Concentrations L. Lindley 1,2, E. Levetin2; IBiology, Northeastern State Universi- ty, Tahlequah, OK, 2Biological Science, University of Tulsa, Tulsa, OK.

84 Aeroallergen Survey of the Texas Panhandle Using a Burkard Volumetric Spore Trap N. Ghosh l, B. Patten I, G. Lewellen I, C. Saadeh 2, M. Gaylor2; IDepartment of Life, Earth and Environmental Sciences, West Texas A & M University, Canyon, TX, 2Amarillo Center for Clini- cal Research/Allergy ARTS, Amarillo, TX.

85 The Impact of Daily Light Level and Weather Parameters on Ragweed Season K. L. Kwak t, C. Barnes], E Hu 2, J. Portnoy2; IAllergy/Asthma/ Immunology, Children's Mercy Hospital, Kansas City, MO, 2Chil- dren's Mercy Hospital, Kansas City, MO.

J ALLERGY CLfN IMMUNOL Abst rac ts $359 VOLUME 111, NUMBER 2

86 Pollen Aeroallergens and Total Airborne Particle Counts M. Reddy ], F. Hu 2, C. Barnes 2, J. Portnoy2; IAllergy/Asthma/ immunology, Children's Mercy Hospital, Kansas City, MO, 2Chil- dren's Mercy Hospital, Kansas City, MO.

87 Effects of El Nino (EN) and La Nina (LA) on the Tree Pollen Counts in the Northeast J. C. DeMasi j , E H. Lewis 2, C. C. Randolph 3, J. M. DeMasi I , P. E. Gallagher4; lprivate practice, Albany, NY, 2private practice, Olean, NY, 3private practice, Waterbury, CT, 4private practice, Erie, PA.

88 Grass Pollen Trends in the New York Metropolitan Area R. Witkowska, P. Benincasa, L. Bielory; Allergy and Immunolo- gy, UMDNJ, Newark, NJ.

89 Ninety-Five Percent of High Tree Pollen Days Have Measur- able Pollen for at Least Twenty Hours of the Day J. J. Anderson; Environmental Allergy Assays, London Health Sciences Centre, London, ON, CANADA.

90 Sensitivity and Exposition to Fungi in Patients with Respirato- ry Allergies from Caracas P. A. Tassinari I, D. Galante j, A. Conesa I, C. Hartung 2, S. Mata 2, Y. C6rdova3; ilnstitute of Immunology, Universidad Central de Venezuela, Caracas, VENEZUELA, 2Institute of Tropical Medi- cine, Universidad Central de Venezuela, Caracas, VENEZUELA, 3Engineering Faculty, Universidad Central de Venezuela, Caracas, VENEZUELA.

91 Comparison of Pre- and Post-Remediation Fungal Spore Levels E Pacheco 1, E Hu 2, C. Barnes 2, J. Pormoy2; ]Allergy/Asthma/ Immunology, Children's Mercy Hospital, Kansas City, MO, 2Chil- dren's Mercy Hospital, Kansas City, MO.

92 Quick Re-mediation of Water Intrusion Corrects the Resultant Mold Contamination in Homes W. J. Rockwell, J. Santilli; Bridgeport Hospital, Bridgeport, CT.

Poster Session 2505


Environmental Agents Causing Asthma and Other Allergic Diseases 93 Predicting Factors for Development of Work-Related Caddis

Fly Allergy E Silviu-Dan t, B. Thomson 2, M. Melanson]; IBoyd Medical Cen- tre, Winnipeg, MB, CANADA, 2Medical Arts Building, Winnipeg, MB, CANADA.

94 Primary Prevention of Natural Rubber Latex Allergy in Health Care Workers H. Allmers 1,2, J. Schmengler 3, C. Skudlik4; IDepartment of Occu- pational Medicine, University of Osnabrueck, Osnabrueck, GER- MANY, 2Department of Dermatology, Environmental Medicine and Health Sciences, University of Osnabrueck, Osnabrueck, GER- MANY, 3prevention Services, Berufsgenossenschaft fuer Gesund- heitsdienst und Wohlfahrtspflege, Delmenhorst, GERMANY, 4Department of Dermatology, Environmental Medicine and Health Sciences, University of Osnabrueck, Osnabmeck, GERMANY.

95 Occupational Asthma Due to Chrome and Nickel Salts: Description of Four Cases M. Fernfindez-Nieto ], S. Quirce I, J. Cuesta I, R. Pelta 2, J. Sastrel; ]Fundaci6n Jim6nez D/az, Madrid, SPAIN, 2Hospital Gregorio Marafi6n, Madrid, SPAIN.

96 Is ENSP (Hey b 13) the Missing Latex Allergen to Fill the Gap in the Repertoire of Isolated Allergens for the Determination of Sensitization Profiles? M:E. Raulf-Heimsoth ] , H. Y. Yeang 2,1. Sander ] , P. Rozynek L S. A. M. Arif 2, C. Fleischer I, R. Cremer 3, T. Briining i, H. Rihs]; iAIler- gology/lmmunology, Berufsgenossenschaftliches Forschungsinstitut for Arbeitsmedizin (BGFA), Bochum, GERMANY, 2Biotechnology and Strategic Research Unit, Rubber Research Institute of Malaysia

(RRIM), Kuala Lumpur, MALAYSIA, 3Children Hospital Cologne, Cologne, GERMANY.

97 Work-Related Symptoms in Italian Hospital Employees Wear- ing Latex Gloves M. L. Pace ], C. Tacconi 2, L. Restivo 2, A. Siracusa2; 1Occupational Medicine and Toxicology, University of Perugia, Perugia, ITALY, 2Occupational Allergology, University of Perugia, Terni, ITALY.

98 Acute and Chronic Changes of Vascular Endothelial Growth Factor (VEGF) in Induced Sputum and Sera of Toluene Diiso- cyanate (TDI)-Induced Asthma Patients H. Park l, J. Choi I, Y. Suh i, C. Suh i, D. Nahm ], S. Lee2; IAllergy and Rheumatology, Ajou University School of Medicine, Suwon, REPUBLIC OF KOREA, 2Department of Internal Medicine, Dong- Ah University School of Medicine, Busan, REPUBLIC OF KOREA.

99 Evaluation of the Prevalence of Anti-Wheat-, Anti-Flour Dust-, and Anti-Alpha Amylase--Specific IgE Antibodies in Blood Donors R. E. Biagini, B. A. MacKenzie, D. L. Sammons, J. P, Smith, C. A. F. Striley, S. A. Robertson, J. A. Snawder; CDC/NIOSH, Cincin- nati, OH.

100 Vietnamese Walking Stick (Baculum extradentatum) Sensitivity H. Sanchez I, E. M. Magnan 2, R. K. Bush3; IReaserch C-4130, VA Hospital, Madison, WI, 2Allergy Immunology, University of Wis- consin, Madison, W1, 3Allergy/hnmunology, University of Wis- consin, Madison, WI.

101 Sensitization of Guinea Pigs to Inhaled Latex (NRL) Can Be Prevented with an Anesthesia Filter J. Barbara j. M. Santais 2, D. A. Levy 3, E Ruff 2, E Leynadier3; ]Laboratoire Universitaire de Recherche en Immuno-Allergologie, Centre d'Allergologie. Hfpital Tenon, Paris, FRANCE, 2Labora- toire de Physiopathologie Respiratoire, UFR Biom6dicale des Saints-P~res, Universit6 de Paris V, Paris, FRANCE, 3Laboratoire Universitaire de Recherche en lmmuno-Allergologie, Centre d' Allergologie, H6pital Tenon, Paris, FRANCE.

102 Trends in the Purchase of Gloves in the Public Hospitals of Paris 1994-2002 D. A. Levy I, P. Regazzoni 2, E Leynadierl; ]Centre d'Allergologie, H6pital Tenon, Paris, FRANCE, 2Agence G6n6rale des Equipements et Produits de Sant6, Assistance Public/H6pitaux de Paris, Paris, FRANCE.

103 Chinchilla Hypersensitivity: A Case Report B. Ferndndez-Parra t, B. Bartolom62, A. Cister6-Bahfmai; JAiler- gy Department, Institut Universitari Dexeus, Barcelona, SPAIN, 2I+d, Laboratorios Bial-Arfstegui, Bilbao, SPAIN.

104 Occupational Rhinitis and Asthma Caused by Tall Wood S. Quiree ] , A. Parra 2, E. Ant6n 3, M. Fern~indez-Nieto I , R. Eir63, P. Usamentiaga 3, J. Sastre l, J. Jerez3; tFundaci6n Jim6nez Diaz, Madrid, SPAIN, 2Hospital Juan Canalejo, La Corufia, SPAIN, 3Hospital Marqu6s de Valdecilla, Santander, SPAIN.

105 Quantitative Structural Activity Relationship and Animal Modeling Accurately Predict the Potential for Human Dermal Sensitization and the Induction of Airway Hyperreactivity Fol- lowing 3-amino-5-mereapto-l,2,4-triazole (AMT) Exposure K. J. Klink i, E. Hnizdo 2, B. J. Meade'; ]AIG/OD Group, Nation- al Institute for Occupational Safety and Health, Morgantown, WV, 2Division of Respiratory Disease Studies, National Institute lk)r Occupational Safety and Health, Morgantown, WV.

106 Identification of Snow Crab Proteins That Elicit IgE Reactivi- ty in Snow Crab Processing Workers B. V. Gill ] , A. Cartier 2, L. Horth-Susin 3. M. Jong ~, M. Swanson 5, B. Neis 6, S. B. LehrerT; JSection of Clinical Immunology, Allergy, and Rheumatology, Tulane University Health Sciences Center, New Orleans, LA, 2H. du Sacre-Coeur de Montreal, Montreal, PQ, CANADA, 3Valley Regional Hospital. Kentville, NS, CANADA, 4Health Labrador Corporation, Goose Bay, NS, CANADA, 5Mayo Clinic, Rochester, MN, 6Memorial University, St-John's, NE CANA- DA, 7Tulane University Health Sciences Center, New Orleans, LA.

S360 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

107 Occupational Allergy due to Trichoplusia Ni Moth M, de las Heras, J. Cuesta, J. de Miguel, C. Escudero, M. Fernfin- dez-Nieto, C. Pastor, F. Vivanco, S. Quirce, J. Sastre; Fundacion Jimenez Diaz, Madrid, SPAIN.

Poster Session 2506


Anaphylaxis 108 Carmine Allergy, a Hidden Cause for Anaphylaxis?

F. L. Lin; Allergy Clinic, Naval Medical Center, San Diego, CA. 109 Anaphylaxis to Indigo Carmine with l]ypotension: Case

Report and Review of the Literature K. M. Sebroederus L,2, M. C. Tobin 3, A. Gewurz3; IAllergy/ Immunology, Rush Presbyterian St. Lukes Medical Center, Chica- go, IL, 2Pediatrics, Cook County Hospital, Chicago, IL, 31mmunol- ogy/Microbiology, Rush Presbyterian St. Lukes Medical Center, Chicago, IL.

110 Stinging Nettle Anaphylaxis M. Morgan, D. A. Khan; Allergy & Immunology, University of Texas Southwestern, Dallas, TX.

111 Anaphylaxis Caused by Buckwheat Ingestion W. F. Schoenwetter; Park Nicollet Clinic, Minneapolis, MN.

112 Anaphylaxis to Horse R. Gawlik 1, T. Pitsch2; t Department & Clinic of Internal, Allergic Diseases, Silesian University School of Medicine, Zabrze, POLAND, 2Department & Clinic of Internal and Allergic Diseases, Silesian University School of Medicine, Zabrze, POLAND.

113 Remission of Anaphylactoid Reaction to Alcohol J. R, Haden t, D. A. Khane; 1Allergy and Immunology, UT South- western, Dallas, TX, 2UT Southwestern, Dallas, TX.

114 Cherry Allergy: Two Cases Report J. Ruiz Palomino, M. Baeza, M. De Barrio; Allergy, HGU Grego- rio Marafion, Madrid, SPAIN.

115 Anaphylactic Reaction to Manioc: Cross-reactivity with Latex? A. Gaspar ], C. Braga i, R. Murta e, M. Morais-Almeida ], J. Rosa- do-Pintol; qmmunoallergy Department, Dona Esteffinia Hospital, Lisbon, PORTUGAL, 2DPC Amerlab, Lisbon, PORTUGAL.

116 Wheat-Dependent Exercise-Induced Anaphylaxis: Case Report and Review of the Literature C. Lowe ], S. Fitzgerald 2, S. A. Lee 2, G. Krishnaswamy2; tPedi- atrics, Quillen College of Medicine and East Tennessee State Uni- versity, Johnson City, TN, 2Internal Medicine, Quillen College of Medicine and East Tennessee State University, Johnson City, TN.

117 Withdrawn 118 Ethanol is a Requisite Cofactor in Anaphylaxis to Spinach

S. D. Betschel 1. P. Vadas2; ~Division of Allergy and Clinical Immunology, St. Michael's Hospital, Toronto, ON, CANADA, 2Division of Allergy and Clinical Immunology, St. Michael's Hos- pital, Toronto, ON, CANADA.

119 Anaphylactic Reaction to the Deerfly, Chrysops spp., with Suc- cessful Response to Immunotherapy T. M. Hrabak 1, J. Dice2; llnternal Medicine, Keesler Air Force Base, Biloxi, MS, 2Lackland Air Force Base, San Antonio, TX.

120 Anaphylaxis to Turmeric D. M. Robinson; Asthma and Allergy, Virginia Mason Medical Center, Seattle, WA.

121 Anaphylaxis with Exercise After Celecoxib + Fruit Bread R. E. Coifman; Allergy & Asthma of South Jersey, Millville, NJ.

122 Nitric Oxide Levels in Patients with Acute Allergic Reactions R. Y, Lin 1, A. Gupta2; LMedicine, St. Vincents Hospital, Manhat- tan, New York, NY, 2Medicine, St. Vincents Hospital, Manhattan, New York, NY.

123 Fatal Anaphylaxis: Postmortem Findings and Associated Comorbid Diseases B. D. Rotskoff I, P. A. Greenberger 2, B. Lifschultz3; INorthwestern Univ Medical School, Chicago, IL, 2Department of Medicine: Allergy and Immunology, Northwestern Univ Medical School, Chicago, IL, 3Office of the Medical Examiner, Cook County, IL.

124 Can Completely Hemolyzed Medical Examiner Specimens Be Used to Detect IgE Antibodies? D. R. Hoffman; Pathology and Laboratory Medicine. E. Carolina Univ Brody Sch Medicine, Greenville, NC.

125 Comparison of Pediatric and Adult Anaphylaxis Cases Pre- senting to Emergency Departments J. H. Friesen 1,2, S. Morchen 1.2, C. S. Kelly 1,2, A. D. Hogant,2; 1Children's Hospital of the King's Daughters, Norfolk, VA, 2East- ern Virginia Medical School, Norfolk, VA.

126 Why Do Parents Not Use EpiPens When Children Experience Anaphylaxis? D. J. Dilay 1, J. R. Roberts2; t Allergy, Meadowood Medical Centre, Winnipeg, MB, CANADA, 2Pediatrics, Section of Allergy, Univer- sity of Manitoba, Winnipeg, MB, CANADA.

127 Clinical Features of Anaphylaxis in Children: 7 Years' Follow- up of 46 Cases A. Cianferoni I, E. Novembre 2, R. Bernardini 3, N. Pucci 3, E. Lom- bardi 4, A. Vierucci3; IPediatrics, Immunology, University of Flo- rence, Florence, ITALY, 2Pediatrics, University of Florence, ITALY, 3pediatrics, University of Florence, Florence, ITALY, 4University of Florence, Florence, ITALY.

128 The Role of Pharmacists in Anaphylaxis Education S. Diamond ], J. Salter 2, D. Hummel3; IPediaPharm, Toronto, ON, CANADA, ~Anaphylaxis Canada, Toronto, ON, CANADA, 3Uni- versity of Toronto, Toronto, ON. CANADA.

Poster Session 2507


Food Hypersensitivity 129 Effect of Amino Acid-Based Formula on Gastroesophageal

Reflux in Infants with Persistent Distress R. G, Heine 1, D. J. S. Cameron 2, D. E. M. Francis I , C. W. Chow 3, J. Brown t , M. Heddle 4, D. J. Moore 4, G. P. Davidson 4, D. J. Hill1; ]Department of Allergy, Royal Children's Hospital, Melbourne, AUSTRALIA, 2Department of Gastroenterology & Clinical Nutri- tion, Royal Children's Hospital, Melbourne, AUSTRALIA, 3Department of Anatomical Pathology, Royal Children's Hospital, Melbourne, AUSTRALIA, 4Centre for Paediatric and Adolescent Gastroenterology, Women's and Children's Hospital, Adelaide, AUSTRALIA.

130 An International Registry of Patients with Eosinophilic Esophagitis J. R, Guajardo l, A. H. Assa'ad t , A. Mishra i , S. C. Jameson I , P. E. Putnam 2, R. J. Noel-', M. H. Collins 3, M. E. Rothenberg]; t Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Division of Gastroenterology, Hepatol- ogy, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

131 Pediatric Patients with Eosinophilic Esophagitis Have a High Prevalence of IgE Sensitization to Multiple Food Antigens A. H. Assa'ad 1, P. E. Putman 2, J. R. Guajardo ], A. Mishra t, R. J. Noel 2, M. H. Collins 3, S. C. Jameson i, M. E. Rothenbergl; IAller- gy and Immunology, Cincinnati Children's Hospital, Cincinnati, OH, 2Gastroenterology. Cincinnati Children's Hospital, Cincinnati, OH, 3pathology, Cincinnati Children's Hospital, Cincinnati, OH.

J ALLERGY CLIN IMMUNOL Abstracts $361 VOLUME 111, NUMBER 2

132 Food-Pollen Cross-Reactivity in Oral Allergy Syndrome and Rhinitis F. Marcucei 1, G. W. Canonica 2, E FratP, L. SensP, A. Riccio 2, A. Garzi 4, E Tanganelli 5, E. Novembre 6, R. Bernardini 6, G. Passalac- qua2; IClinica Pediatrica University of Perugia, Perugia, ITALY, 2Department of Internal Medicine, Genoa University Allergy & Resp, Diseases, Genoa, ITALY, 3Children's Hospital University of Pemgia, Pemgia, ITALY, 4pediatric Surgery University of Siena, Siena, ITALY, 5Surgical Pathology University of Siena, Siena, ITALY, 6Clinica Pediatrica University of Florence, Florence, ITALY.

133 Anglo-edema and Oral Allergy Syndrome Due to the Con- sumption of Carica Papaya L. S. De Clerck, D. G. Ebo, C. H. Bridts, W. J. Stevens; Immunol- ogy-Allergology-Rheumatology, University of Antwerp, Antwer- pen, BELGIUM.

134 Identification of Specific-lgE to Mesquite Wood Smoke in Indi- viduals with Mesquite Pollen Allergy D, R. More, L. L. Hagan, B. Whisman, D. JordanWagner; Depart- ment of Allergy and Immunology, Wilford Hall Medical Center. Lackland AFB, TX.

135 Goat's and Sheep's Milk Allergies in Children in the Absence of Cow's Milk Allergy E. Bidat I, E Ranc62, T. Baran~s ], S. Goulamhoussenl; JH6pital Ambroise Par6, Boulogne, FRANCE, 2H6pital des Enfants, Toulouse, FRANCE.

136 Heiner Syndrome: Neither Gone, nor Forgotten I. J. Moissidis, S. L. Bahna; Allergy/Immunology, Louisiana State University Health Sciences Center, Shreveport, LA.

137 Adequacy of Dietary Calcium in Milk Allergic Children J. K. Knaack I, M. B. Levy2; ]Asthma/Allergy Clinic, Children's Hospital of Wisconsin, Milwaukee, Wl, 2pediatrics, Medical Col- lege of Wisconsin, Milwaukee, Wl.

138 Biochemical Basis for Hypoallergenic Properties of Reoxidized [3-Lactoglobulin S. MorigasakP, H. Jung i, O. L. Frick 2, B. B. Buchanani; I Univ. of California, Berkeley, CA, 2Univ. of California, San Francisco, CA.

139 Choice of Formula for Infants with a Sibling Who Had an Allergy to Cow's Milk E. S. Chart l, M. S. C. Choi 2, E E. R. Simons l, W. T. A. Watson ~, A. B. Becke0; IPediatric Allergy & Clinical Immunology, Univer- sity of Manitoba, Winnipeg, MB, CANADA, 2pediatrics, Universi- ty of British Columbia, Vancouver, BC, CANADA.

140 Increased Epithelial Permeability and the Generation of Inflammatory Cytokines in Response to Proteolytic Activity in Fruit M. G. Buckley, A. E Walls; lmmunopharmacology Group, Uni- versity of Southampton, Southampton, UNITED KINGDOM.

141 Presentation of Allergen in Different Food Preparations May Affect the Severity of the Allergic Reaction J. O. Hourihane ], K. E. C. Grimshaw I, R. M. King 2, J. M. Nordlee 3, S. L. Hefle 3, J. O. Warneri; IUniversity of Southampton, Southampton, UNITED KINGDOM, 2Southampton University Hospital Trust; Wellcome Trust Clinical Research Facility, Southampton, UNITED KINGDOM, 3University of Nebraska-Lin- coln, Lincoln, NE.

142 Transglutaminase Not Foolproof in Diagnosis of Celiac Disease in Children Z. K. Beams, J. D. Lloyd-Still, R. Sandler, R. McConnie, S. Jakate; Rush Medical College, Chicago, IL,

143 Comparison of Allergic Sensitization/Response to Soybean in the Neonatal Swine Peanut Allergy Model R. M. Helm 1,2, G. T. Furuta 3, J. S. Stanley i,2, C. M. West L2, G. CockrelP ,2, C. Connaughton 1.2, A. W. Burksl.2; ipediatrics, Uni- versity of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children's Hospital, Little Rock, AR, 3Harvard Medical School, Boston, MA.

144 Thl Mediated Non-IgE Food Allergy and ILNH: A New Rela- tionship? J. Malka-Rais I, J. A. BellantP, A. Sabra2; IPediatrics-Immunolo- gy, Georgetown University Medical Center, Washington, DC, 2pediatrics-Pediatric Gastroenterology, Universidade do Grande Rio, Rio de Janeiro, BRAZIL.

145 The Effect of IgG Removal on Detection of Murine Allergen- Specific lgE L. G. Wild 1, G. Dai l, R. Reish 2, J. Fernandes 2, P. Gaudry I, G. Reese -~, S. B, Lehrerl; J Medicine-Clinical Immunology, Tulane University Health Sciences Center, New Orleans, LA, 2Department of Biology, Paul Tulane College, New Orleans, LA, 3PauI-Ehrlich- lnstitut, Langen, GERMANY.

146 Seafood Allergy: Clinical Manifestation in Thai Patient Who Was Referred to Referral Allergy Center, Siriraj Hospital D, Chaidaroon [. N. Visitsunthron 2, P. Vichyanond2; IPediatrics, Allergy and Immunology, Bangkok, THAILAND, 2Department of Pediatrics, Allergy and Immunology, Bangkok, THAILAND.

147 Meat Allergy and Cross-Reactivity with Hamster Epithelia A. Cister6-Bahlma i, E. Enrique ], M. San Miguel-Moncin I, R. Alonso 1, J. Bartra I, B. Fermindez-Parra I, M. Lombardero 2, D. Bar- ber2; IAllergy Department, lnstitut Universitari Dexeus, Barcelona, SPAIN, 2R&D Department, ALK-AbelI6, S.A., Madrid, SPAIN.

148 IL-10 induces Antigen-Specific T-Cell Anergy but no Regulato- ry T Cells in Children with Egg Allergy P. A. EigenmannL L. TropiaL C. Hauser 2, C. P. Frossardl; IUni- versity Children's Hospital, Geneva, SWITZERLAND, 2Depart- ment of Medicine, Geneva, SWITZERLAND.

149 Incidence of Allergen Specific IgE Antibodies in Serum, and Variability by Age, in a Large Japanese Population S. Kimura; Central Clinical Laboratory, Showa University North- ern Yokohama Hospital, Yokohama, JAPAN.



Improving the Quality of Care of Asthma 150 Barriers to Asthma Control Are Associated with Future Health-

care Utilization in Patients with Severe or Difficult-to-Treat Asthma S. E. WenzeP, C. M. Dolan 2, Y. Deniz 2, B. Zheng 2, S. Weiss3; INational Jewish Medical and Research Center, Denver, CO, 2Genentech, Inc. South San Francisco, CA, 3Harvard Medical School, Boston, MA.

151 Safety of Zyrtec (Cetirizine Hydrochloride) in Infants by Dose J. Portnoy J, P. Silas 2, J. A. Catuogno 3, C. Dubois 4, G. FarfeP; ~Section of Allergy/hnmunology. Children's Mercy Hospital, Kansas City, MO, 2Wee Care Pediatrics, Layton, UT, 3Clinical Development, Pfizer Inc, New York, NY, 4UCB Pharma, Braine A'lleud, BELGIUM.

152 Treatment of Allergic Rhinitis in Patients with Comorbid Asth- ma: Inhaled Nasal Corticosteroids (INS) Versus Oral Antihist- amines (OAH) L. O'Dowd l, C. Roberts 2, T. McLaughlin 3. C. Leibmanl: IAstraZeneca LP, Wilmington, DE, 2NDCHeahh, Yardley, PA, 3NDCHeahh, Phoenix, AZ.

153 Writing Wrongs?: An Evaluation of the Readability and Accu- racy of Information Leaflets for People with Hay Fever H. E. Smith i, P. White 2, A. Frew3; IPrimary Medical Care, Uni- versity of Southampton, Southampton, UNITED KINGDOM, 2Nightingale Surgery, Romsey, UNITED KINGDOM, 3University of Southampton, Southampton, UNITED KINGDOM.

154 Asthma Camp Education Provides Short-Term Health Benefits C. H. Song l, C. H. Pollak 2, D. Ershofl~; IPediatrics, Harbor-

$362 Abs t rac ts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

UCLA Medical Center, Torrance, CA, 2Asthma and Allergy Foun- dation of America, Los Angeles, CA.

155 Healthcare Cost Analysis of Allergic Rhinitis Treatment: Budesonide Aqueous Nasal Spray Versus Loratadine C. Roberts 1, C. Leibman 2, T. McLaughlin3; INDCHealth, Yardley, PA, 2AstraZeneca LP, Wilmington, DE, 3NDCHealth, Phoenix, AZ.

156 Physician Knowledge Base in Use of Asthma Medication Deliv- ery Devices J. A. Garner I , H. Nguyen 2, C. Hiatt 3, N. Olson2; 1pediatrics, Uni- versity of Kansas Medical Center, Kansas City, KS, 2Allergy/ Immunology, University of Kansas Medical Center, Kansas City, KS, 3University of Kansas Medical Center, Kansas City, KS.

157 Are Clinical Practice Guidelines Applied to Asthmatics in a University-Based Internal Medicine Residents' Clinic? P. F. Maloney 1, J. P. Boglia 2, R. M. Mormando3; IDepartment of Medicine, Division of Allergy & Immunology, SUNY at Stony Brook, Stony Brook, NY, 2Department of Medicine, SUNY at Stony Brook, Stony Brook, NY, 3Department of Medicine, SUNY at Stony Brook, Stony Brook, NY.

158 Asthma-Related Resource Use by GINA Classification in 3 European Countries D. D. Yin ], E. van Ganse 2, L. Antonicelli 3, Q. Zhang ~ , K. Naber- an 4, G. Nocea 5, J. Bousquet6; IOutcomes Research, Merck & Co, Inc, Whitehouse Station, N J, 2Centre Hospitalier Lyon-Sud (CHLS), Lyon, FRANCE, 3Dip. Malattie Respiratorie ed Aller- giche, Ospedale Umberto I, Ancona, ITALY, 4Universidad de Barcelona, Barcelona, SPAIN, 5Merck Sharp & Dohme, Espafia, Madrid, SPAIN, 6University of Montpellier Hospital Arnaud de Velleneuve, Montpellier, FRANCE.

159 Urban Minority Children Visit Complementary and Alterna- tive Medicine (CAM) Practitioners for Asthma Care G. B. Zuckermau, L. Bielory; Division of Allergy/Immunology, New Jersey Medical School-UMDNJ, Newark, NJ.

160 Effect of Adding Leukotriene Modifier or Salmeterol to Inhaled Corticosteroids on Outcomes: Confounding Factor in Assessing Effectiveness D. Bukstein 1, H. Henk 1.2, A. Luskinl; IDean Foundation for Health, Research and Education, Middleton, WI, 2University of Wisconsin, Madison, WI.

161 Documentation of Asthma Care on Clinical Records: Evaluat- ing Process of Care Indicators Based on NIH/GINA Asthma Guidelines D. Malbeiro I , J. A. Fonseca 1.2, J. L. Delgado 1,3, A. Costa-Pereira 2. S. Cadinha I, C. Tavares 2, M. Vazl; IUnidade de Imunoalergologia, Hospital S. Jofio, Porto, PORTUGAL, 2Servi~:o de Bioestatfstica e Inform~itica M6dica, Faculdade de Medicina da Universidade do Porto, Porto, PORTUGAL, 3Serviqo de Imunologia, Faculdade de Medicina da Universidade do Porto, Porto, PORTUGAL.

162 Asthma Management in the Internal Medicine Resident Clinic of a Community Hospital C. B. Lauter ]. R. Singh2; ]Division of Allergy, Immunology, William Beaumont Hospital, Royal Oak, MI, 2William Beaumont Hospital, Royal Oak, MI.

163 The Use of Alternative Medicine as Treatment for Allergic Diseases F. J. A. AIfredo; Centro de Alergia e Inmunologia Clinica, Hospi- tal Universitario, Monterrey, MEXICO.

Poster Session 2509

Saturday, M a r c h 8 11:15 A M to 12:15 P M

T Cells and Cell Signaling 164 Allergen Specific Human Th2 Cells Express a Unique

Chemokine Receptor Repertoire B. Foster, C. Prussin; National Institute of Allergy and.Infectious

Diseases/Laboratory of Allergic Diseases. National Institutes of Health, Bethesda, MD.

165 Involvement of CD4+CD25+ T Regulatory Cells in Immune Responses of Latex Sensitized Mice B. Banerjee, B. D. Johnson, E Naik, J. N. Fink, K. J. Kelly, V. P. Kurup; Pediatrics, Medical College of Wisconsin, Milwaukee, Wl.

166 Effect of TGF-beta on Cow's Milk-Specific T Cells Derived from Allergic and Non-Allergic Children M. M. Tiemessen l, S. Kunzmann 2, C. B. Schmidt-Weber 2, M. A. Hoijer 3, C. A. E Bmijnzeel-Koomen], E. Van Hoffen I , E. E Knoll; ]Department Dermatology/Allergology, University Medical Center Utrecht, Utrecht, NETHERLANDS, 2Swiss Institute of Allergy and Asthma Research, Davos, SWITZERLAND, 3Numico Research, Wageningen, NETHERLANDS.

167 Expression of SNARE Proteins by Human Lymphocytes: Possi- ble Role in Regulated Release of Mediators of Immune Response S. O. Odemuyiwa j, K. Lo I, P. Lacy 1, R. C. Bleackley 2, R. Moq- bel L ; I Medicine, University of Alberta, Edmonton, AB, CANADA, 2Biochemistry, University of Alberta, Edmonton, AB, CANADA.

16B Allergen Specific Th2 Cytokine Expression Is Independent of CD28 Costimulation H. N. Thai, B. Foster, C. Prussin: Laboratory of Allergic Diseases, National Institutes of Health, Bethesda, MD.

169 Allergen-Driven T Cell Proliferation and Cytokine Production Can Be Suppressed by Human CD4+CD25+ Regulatory T Cells: In Atopic Subjects Suppression Is Less Efficient than in Non-atopics E. M. Ling, D. S. Robinson; Allergy and Clinical Immunology, National Heart and Lung Institute and Leukocyte Biology, Imperi- al College, London, UNITED KINGDOM.

170 Dermatophagoides Farinae (Der f I) Activates Phospholipase D in T Cells from Der f I Specific Allergic Individuals J. W. Oh j, H. B. Lee 2, J. S. Han3: 1Pediatrics, Hanyang Universi- ty Kuri Hospital, Kuri-Shi, Kyunggi-Do, REPUBLIC OF KOREA, 2Pediatrics, Hanyang University, Seoul. REPUBLIC OF KOREA, 3Biochemistry, Hanyang University, Seoul, REPUBLIC OF KOREA.

171 Flow Cytometrical Identification of Decidual Lymphocytes W. J. Stevens L, M. M. Hagendorens 2, A. J. Schuerwegh t, D. G. Ebo 1, L. S. De Clerck ~, C. H. Bridts 1, H. P. Van Bever2: ]Immunol- ogy-Allergology-Rheumatology, University of Antwerp, Antwer- pen, BELGIUM, 2Pediatrics and Immunology, University of Antwerp, Antwerpen, BELGIUM.

1"12 Prevention of Glncocorticoid Receptor (GCR) Nuclear Translocation: A Novel Mechanism of IL-2-induced Steroid Resistance in T Cells E. Goleva j, K. O. Kisich 2, D. Y. M. Leungl; tpediatrics, National Jewish Medical & Research Center, Denver, CO, 2Basic Science, National Jewish Medical & Research Center. Denver, CO.

173 STAT-1 is a Major Factor Regulating Allergen-Induced Airway Inflammation and Hyperreactivity D. Quarcoo l, S. Weixler t, R. Joachim 2. D. Groneberg I, B. Ahrens L, A. H. Wagner 3, M. Hecker 3, E. Hamelmannl; IDepart- ment of Pediatric Pulmology and Immunology, CharitE-Humboldt University, Berlin, GERMANY, 2Department of Internal Medicine, Charit6-Humboldt University, Berlin, GERMANY, 3Department of Cardiovascular Physiology. University of Gt~ttingen, GOttingen, GERMANY.

1"/4 The Rho-related GTPase Rac2 Is Essential for Regulation of Neutrophil Aznrophilic Granule Release P. Lacy I, D. Abdel Latif I, M. Steward 1, D. Macdonald l, G. A. Francis I, E W. Tse 2, M. C. Dinauer3; IMedicine, University of Alberta, Edmonton, AB, CANADA, 2pharmacology, University of Alberta, Edmonton, AB, CANADA, 3pediatrics (Hematology/ Oncology), Herman B. Wells Center for Pediatric Research, Indi- ana School of Medicine, Indianapolis. IN.

J ALLERGY CLIN IMMUNOL Abstracts S363 VOLUME 111, NUMBER 2

175 Quantification of Glucocorticoid Receptor (GR) Activation and Translocation: A Novel Method A. Petrov ], N. Burke 2, C. M. Neely 3, M. L. Robinson 3, S. Watkins 2. B. T. Ameredes 3, W. J. Calhoun3; IAllergy, University of Pittsburgh, Pittsburgh, PA, 2Cell Biology and Physiology, Univer- sity of Pittsburgh, Pittsburgh, PA, 3AAARC: Pulmonary, Allergy, and CCM, University of Pittsburgh, Pittsburgh, PA.

176 Surfactant Protein (SP)-D Inhibits T Cell Dependent Allergic Responses A. Haczku, Y. Tomer, S. T. Scanlon, Y. Cao, M. E Beers; Medicine, University of Pennsylvania, Philadelphia, PA.

177 Mannose Receptor Mediated Sustained Activation of Extracel- lular Regulated Kinase 1 and 2 (ERKI/2) Is Dependent on Fibronectin Synthesis in Human Airway Smooth Muscle Cells (ASMC) L. Young, D. B. Lew; Pediatrics, UTHSC, Memphis, TN.

178 Expression of Protein Tyrosine Kinase Syk in Airway Epithelial Cells: Functional Implications M. Uianova I, L. Puttagunta 2, M. Duszyk 3, A. Szkotak 3, A. D. Schreiber 4, D. Befus]; IMedicine, University of Alberta, Edmon- ton, AB, CANADA, 2Laboratory Medicine and Pathology, Univer- sity of Alberta, Edmonton, AB, CANADA, 3physiology, Universi- ty of Alberta, Edmonton, AB, CANADA, 4Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA.

179 Modular Organization of the Carboxy-Terminal, Globular Head Regions of Human Clq A, B, and C Chains S. K. Gup ta 1, M. V. Perdikoulis I, M. S. Kojouharova 2, B. C. Urban 3, K. B. M. Reid I, U. Kishore3; IMedical Research Council Immunochemistry Unit, University of Oxford, Oxford, UNITED KINGDOM, 2Department of Biochemistry, Sofia University, St. Climent Ohridsky, Sofia, BULGARIA, 3Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UNITED KINGDOM.

180 The Role of H3 Histamine Receptors in IgE Production R. Khanferyan t, N. Riger I, N. Kotova j, W. Schunack 2, L. M. Du Buske3; qnstitute of Allergy and Asthma, Krasnodar, RUSSIAN FEDERATION, 2Inst. of Pharmacology, File University of Berlin, Berlin, GERMANY, 3Immunology Research Institute of New Eng- land, Fitchburg, MA.

Poster Session 2510


Cytokines and Alle~c Inflammation 181 Interferon-7 Induces 2, 3-Dioxygenase Expression in Human

Peripheral Blood Eosinophils: Role in Eosinophil Survival? A. G. Ghahary], S. O. Odemuyiwa I , J. Lee I , J. Lee 2, A. Ghahary 2, R. Moqbel]; IMedicine, University of Alberta, Edmonton, AB, CANA- DA, 2Surgery, University of Alberta, Edmonton, AB, CANADA.

182 Tryptase and Other Agonists of Protease Activated Receptor-2 (PAR-2) Stimulate the Generation of Inflammatory Cytokines From Human Lung Fibroblasts and Myofibroblasts S. Hase, A. Richter, X. Y. Zhou, M. Buckley, A. Aslam, A. R. McEuen, A. E Walls; University of Southampton, Southampton, UNITED KINGDOM.

183 IL-5 Release by Enriched Human Bone Marrow CD34+ Cells M. Sjiistrand; Lungpharmacology Group, Respiratory Medicine and AIlergology, Internal Medicine, G6teborg University, SWEDEN.

184 Comparative Effects of IL-3, IL-5, and GM-CSF on Human Basophils and Eosinophils C. Ynshimura j, H. Nagase 1, T. Fujisawa 2, M. Yamaguchi I, T. lwata ], T. Igarashi ], K. Yamamoto j, K. Hirai]; IUniv. of Tokyo Graduate School of Medicine, Tokyo, JAPAN, 2National Mie Hos- pital, Mie, JAPAN.

185 Cyclooxygenase (COX) Inhibition at the Time of Initial Anti- gen Presentation Results in Enhanced IL-13 and IgE P. W. Jones, K. Goleniewska, J. Furlong, J. R. Sheller, K. Hashimoto, J. D. Morrow, R. S. Peebles; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

186 IFN-TAntagonizes IL-5-mediated Eosinophil Activation C. Park j, M. K. Choi 2, S. Y. Whang], I. Y. Chung2; JAllergy and Respiratory Medicine, Soonchunhyang University Hospital, Bucheon-Si, REPUBLIC OF KOREA, 2Biochemistry and Molecu- lar Biology, Hanyang University, Ansan, REPUBLIC OF KOREA.

18"I Expression of Histamine Receptors H1R, H2R, and H4R and Effects of Histamine on Cytokine Expression in Human Intesti- nal Mucosa L. E. Sander, A. Lorentz, G. Sellge, M. P. Manns, S. C. Bischoff; Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, GERMANY.

188 Nerve Growth Factor (NGF) Activates Human Lung Myofi- broblasts: A Role for NGF in Tissue Repair A. Micera z, I. Puxeddu j , E Alviano 1, L. Aloe 2, E Levi-Schafferl; ~Department of Pharmacology, The Hebrew University of Jerusalem, Jerusalem, ISRAEL, 21nst of Neurobiology and Molec- ular Medicine, National Research Council, Rome, ITALY.

189 CD2 Induced Calcium Responses and IL-12RI32 mRNA Expression in Relation to Atopy C. K. Janefjord, M. C. Jenmalm; Department of Molecular and Clinical Medicine, Division of Paediatrics, Link0ping, SWEDEN.

190 Olopatadine Inhibits Conjunctival Mast Cell-Mediated and fMLP Stimulated Eosinophil Degranulation but not Mast Cell- Mediated Adhesion of IL-5 Primed Eosinophils J. L. Stahl I , E. B. Cook I , J. B. Sedgwick ] , H. Kito 2, N. P. Barney 3, E M. Grazianol; ]Medicine, University of Wisconsin-Madison, Madison, WI, 2Medicine, Mayo Clinic, Rochester, MN, 3Ophthal- mology & Visual Sciences, University of Wisconsin-Madison, Madison, W1.

191 Costimulation with MIP-1 alpha and lgE-antigen Enhances Degranolation but Inhibits Chemotaxis in RBL-2H3 Cells Expressing Human CCRI M. TodaJ, T. Nakamura j, R. M. Richardson 2, S. J. On03; tlnstitute of Ophthalmology, University College London, London, UNITED KINGDOM, 2Meharry Medical College, Nashville, TN, 3Institutes of Ophthalmology and Child Health, University College London, London, UNITED KINGDOM.

192 Allergen-Driven Increase of Newly Produced Airway CD34+ Cells-Role of IL-5 S. Sergejeva 1, A. K. Johansson ] , C. Malmhall 1, N. A. Lee 2, J. L~t- vail]; I Department of Respiratory Medicine and Allergology, Insti- tute of Internal Medicine, G6teborg, SWEDEN, 2Department of Biochemistry and Molecular Biology, Division of Pulmonary Med- icine, Scottsdale, AZ.

193 Interleukin-10 Inhibits Allergen Specific Th2 Cytokine Expres- sion in Allergic Asthma Y. Cheng I, N. Zhong2; I National Institutes of Health, Bethesda, MD, 2Guangzhou Institute of Respiratory Disease, Guangzhou, CHINA.

194 Immunologic Properties of Regenerative Epidermal Sprouts (ES) During Colonization with Langerhans Cells (LC) G. N. Drannik ], A. 1. Kurchenko 1, L. M. Du Buske2; JNational Medical University, Department Clinical Immunology and Aller- gology, Kiev, UKRAINE, 2Immunology Research Institute of New England, Fitchburg, MA.

195 Anti-Allergic Effects of IL-12 Are Mediated by Enhancement of Apoptosis of Lung Immune/Inflammatory Cells T. Kodama j, K. Kuribayashi 2, K. Takeda 1, N. Miyahara I, T. Mat- suyama 2, O. Kitada 2, M. Sugita 2, A. Dakhama t, E. W. Gelfandi; I Pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Internal Medicine, Hyogo College of Medicine, Nishi- nomiya, JAPAN.

S364 Abst rac ts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

196 Dual Modulation of 15-Deoxy-AR,14-prostaglandin Jz in Human Leukemia Call Line THP-1 Y. Azuma, K. Ohura; Department of Pharmacology, Osaka Dental University, Hirakata, JAPAN.

Poster Session 2511


Improving Allied Health Practice Through Research 197 Asthma Counseling: A Strategy for Reducing Asthma Symptoms

S. Sarpong, R. I, Quartey, S. Greeley, E. Thornton, R. Brown, E. Reece, J. Kwagyan, E. S. Ford, E J. Malveaux: Howard Universi- ty, Washington, DC.

198 Eosinophilic Bronchitis in Patients with Chronic Cough M. M. Pries, L. J, B. Davis, C. R. Weiler; Allergy, Mayo Clinic, Rochester, MN.

199 Self Efficacy as a Predictor of Indoor Allergen Control K. A. Callahan j , P. A, Eggleston I , N. Durkin 2, S. Kanchanaraksa 2, R. A, Wood l, C. S. Randq qohns Hopkins University, School of Medicine, Baltimore, MD, 2Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD.

200 Pharmacy Service Interventions in Pediatric Inner City Asthma B. Dierschke, C. Berge; Pharmacy, Parkland Health & Hospital System, Dallas, TX.

201 Caregiver Depression and Pediatric Asthma Morbidity in an Inner City Population L, J. Swartz ~, J. M. Curtin-Brosnan 2, S. Kanchanaraksa z, C. S. Rand 3, P. R. Thomas I , P. A. Eggleston~; I Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 2Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 3Medicine-Pulmonary, Johns Hopkins University School of Medicine, Baltimore, MD.

202 Compliance with Dietary Advice to Pregnant Women to Avoid Peanut Consumption E. M. Oliver, K. E. C. Grimshaw, J. O. Warner, J. O. Hourihane: School of Medicine, University of Southampton, Tremona Road, Southampton, UNITED KINGDOM.

203 Caregiver Perception of Asthma Symptoms in Children K. E. Mudd I, M. E. Bollinger I, K. Huss 2, A. Butz3; IPediatrics, University of Maryland School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Nursing, Baltimore, MD, 3Pediatrics, Johns Hopkins University School of Medicine, Balti- more, MD.

204 Major Variability in the Prevalence of Rhinosinusitis (RS) Depending on Diagnostic Criteria E. Horowitz I, E DiemerL J. Poyser I, P. Stivers ~, L. G. Jean t, V. Britt 2, M. Knight 2, A. Togiasl; I Johns Hopkins University, Balti- more, MD, 2Housing Authority of Baltimore City, Baltimore, MD.

205 Asthma and Rhinoconjunctivitis Caused by Rice in a House- wife: A Case Report R, Gonz~ilez-Meudiola ~ , J. Campos 2, P. Prieto I , M. Garcia I , T, Mufioz I, B. De La Hoz I, M. Sfinchez-Canol; 1Allergy, Hospital Ram6n y Cajal, Madrid, SPAIN, 21mmunology, Hospital Ram6n y Cajal, Madrid, SPAIN.

206 A Correlation of Skin Test Reactivity Between Two Dust Mite Species, D. pteronyssinus vs D. farinae D. K. Harmon, B. A. Miller: Internal Medicine/Allergy/Immunol- ogy, University of Kentucky, Lexington, KY.

20"/ Anaphylaxis in the School Setting J. M, Dunn, J. M. DeMasi; private practice. Albany, Nu

208 Criteria for Selecting an IGIV Preparation: The Infusion Nurs- es' Perspective J. Davis I, K. Duff 2, S. Ganio 3, L. Garrow-Harris ~, J. Gomez ~, P. MacPherson 6, B. Nolet 7, C. Scarlet 8, C. Underhill 9, M. Willl~

J Johns Hopkins University, Baltimore, MD, 2University Hospitals of Cleveland, Middleburg Heights, OH, 3The Office of Dr. Michael Cichon, Tampa, FL, 4Gentiva Health Services, Ft. Lauderdale, FL, 5New York Weill Cornell Center, New York, NY. 6Center for Blis- tering Diseases, Boston, MA, 7Northwest Management Associates, Gig Harbor, WA, 8University of Utah lmmunology/Gentiva, Park City, UT, 9Allergy Associates at the Palm Beaches, Palm Beach Gardens, FL, 1~ for Rheumatic Disease, Allergy and Immunology, Kansas City, MO.

209 The Impact of Short-Term, Intense Asthma Education upon Knowledge and Asthma Outcomes in Inner-City Schoolchildren E. J. Saturno ~, M. Mvula 2, M. Larzelere 3, R. Post 4, B. Marrow 5, J. Alexander 5, K. Moisiewicz 6, C. M. Moorel; IPediatrics, LSU Health Sciences Center, New Orleans, LA, 2pediatrics, LSU Health Science Center, New Orleans, LA, 3Family Medicine, LSU Health Sciences Center, New Orleans, LA, 4Family Medicine, LSU Health Science Center, New Orleans, LA. 5LSU Health Science Center, New Orleans, LA, 6School of Nursing, LSU Health Sciences Cen- ter, New Orleans, LA.

210 Perennial Allergic Rhinitis (PAR): More Severe Than Seasonal? F. Diemer, A. Sanico, A. Togias: Johns Hopkins University, Balti- more, MD.

211 Asthma Self-Efficacy and Knowledge of Rural School Health Personnel (SHP) M. L. Winkelstein 1, R. E. Thompson 2, B. Calabrese 3, R. I. Quartey 4, A. M. Butz 5, C. S. Rand 3, R. W. Huss 6, K, Hussl; 1School of Nursing, Johns Hopkins University, Baltimore, MD, 2Bloomberg School of Public Health. Johns Hopkins University, Baltimore, MD, 3School of Medicine, Johns Hopkins University, Baltimore, MD, 4College of Medicine, Howard University, Wash- ington, DC, 5Department of Pediatrics, Johns Hopkins University, Baltimore, MD. 6Asthma Sinus and Allergy Centers, LLC, East Brunswick, NJ.

212 Allied Health Skin Testing Workshop D. Laforest, R. Daugherty, M Schwarz; Allergy and Asthma Cen- ter, Fort Lauderdale, FL.

213 Asthma Induced by Inhaling Lumbrokinase Aerosol W. LP; Allergy, Peking Union Medical College Hospital, Beijing, CHINA.

214 Relation Between Objective Measures of Asthma and Atopy E. O. Corazalla; University of Minnesota, Minneapolis, MN.

215 The Effectiveness of Asthma Education on Reducing the Inci- dence and Severity of Asthma Episodes During a Two-Week Period in African American Children Between the Ages of 7-12 J. R. Edwards l, D. Calloway l, M. Caprarola I, R. Hollander I , S. Ford2; IHealth Education. Howard University, Washington, DC, 2Pediatrics, Howard University Hospital, Washington, DC.

Sinusitis 2:15 216

2:30 217

Ora l Abs t rac t Session 2711

Saturday, M a r c h 8 2:15 P M to 4:15 P M

High-Resolution HLA Class II DNA Haplotyping in Allergic Fungal Rhinosinusitis and Hypertrophic Sinus Disease: The Role of HLA DQ3 M. S. Schubert I, P. S. Hutcheson 2, R. J. Graft ~, R, G. Slavin2; ~Allergy Asthma Clinic, Phoenix. AZ, 2St. Louis University, St. Louis, MO.

Resolution of Acute Sinusitis Requires the T-Cell Adaptive Immune Response C. L. Blair t , X. YuL K. Thompson 2. E Baroody L , R. M. Naclerio I , A. 1. Sperling 3: IOtolaryngology-Head & Neck Surgery, The Uni-

J ALLERGY CLIN/MMUNOL A b s t r a c t s $365 VOLUME 111, NUMBER 2

2:45 218

3:00 219

3:15 220

3:30 221

3.'45 222

4:OO 223

versity of Chicago, Chicago, IL, 2Department of Pathology, The University of Chicago, The University of Chicago, IL, 3Depart- ment of Medicine: Pulmonary and Critical Care, The University of Chicago, Chicago, IL.

The Interaction of Allergy and Bacterial Sinusitis in Mice X.Yu I , C. L. Blair l, K. Thompson 2, E Baroody I , A. I. Sperling 3, R. M. Nacleriol; lOtolaryngology-Head & Neck Surgery, The Univer- sity of Chicago, Chicago, IL, eDepartment of Pathology, The Uni- versity of Chicago, Chicago, IL, 3Department of Medicine: Pul- monary and Critical Care, The University of Chicago, Chicago, IL.

Evidence of Maxillary Sinus Inflammation in Seasonal Allergic Rhinitis (SAR) F. M. Baroody, S. Mucha, M. L. deTineo, B. Maleckar, R. M. Naclerio; University of Chicago, Chicago, IL.

Predominance of Pseudomonal Sinusitis After Medical Thera- py for Sphenoid Sinusitis D. L. Keitel, R. E. Foutch, J. J. Murray, J. A. Duncavage, D. D. Hagaman, S. Tanner; Asthma Sinus Allergy Program, Vanderhilt University, Nashville, TN.

Extensive Degranulation of Eosinophils in the Mucin, but not in the Tissue, of Chronic Rhinosinusitis Patients J. U. Ponikau, G. M. Kephart, E. B. Kern, D. A. Sherris, H. Kita; Mayo Clinic, Rochester, MN.

Recurrence Rate of Sphenoid Sinusitis After Medical Therapy S. Tanner, D. L. Keitel, R. E. Foutch, J. A. Duncavage, D. D. Hagaman, J. J. Murray; Asthma Sinus Allergy Program, Vanderbilt University, Nashville, TN.

Chronic Rhinosinusitis (CRS) in Young Children Differs from CRS in Adults: A Histopathology Study K. H. Chan 1, M. J. Abzug 2, L. Coffinet 3, E. A. E Simoes e, C. Cool 4, J. Y. Westcott 5, A. H. Liu2; JOtolaryngology, University of Colorado School of Medicine, Denver, CO, 2Pediatrics, University of Colorado School of Medicine, Denver, CO, 3Service ORL, Hopital Central, Nancy, FRANCE, 4Pathology, University of Col- orado School of Medicine, Denver, CO, 5National Jewish Medical and Research Center, Denver, CO.


Saturday, March 8 2:15 PM to 4:15 PM

Asthma Management: Anti-Inflammatory Therapy 2.'15 224 Long-Term Effectiveness of the Fluticasone Propionate/Salme-

terol (FSC) 100/50 meg Combination Product as an Inhaled Corticosteroid Sparing Agent P. Dorinsky, S. Yancey, D. Reilly, L. Edwards, K. Rickard; Glaxo- SmithKline, Research Triangle Park, NC.

2.'30 225

2:45 226

In Vitro Measures of Giucocorticoid Response in Asthma R. A. Covar, E. Brown, J. D. Spahn; Clinical Pharmacology, National Jewish Medical and Research Center. Denver, CO.

Effects of Valved Holding Chamber Electrostatic Charge on Delivery of Beelomethasone Dipropionate from a Hydrofluo- roalkane Metered Dose Inhaler C. J. Amerman, M. J. Asmus, M. Issar, V. Arya, I. Coowanitwong, G. Hochhaus; College of Pharmacy, University of Florida, Gainesville, FL.

3:00 227 Montelukast or Salmeterol Added to Fluticasone in Uncon-

trolled Asthma: A Subgroup Analysis of the IMPACT Study P. G. Polos; Merck & Co, Inc, Whitehouse Station. NJ.

3:15 228 Combination of Salmeterol (SAL) and Fluticasone (FP) Works

Synergistically to Inhibit Airway Inflammation Post Allergen Challenge C. Swenson, J. Laseman, W. Busse; University of Wisconsin, Madison, WI.

3:30 229 Symptom-Guided Adjustable Dosing Asthma Therapy with

Budesonide and Formoterol in a Single Inhaler - -The ATACO Study R. Buhi j , P. Kardos 2, A. Baare 3, K. Richter 4, W, Meyer-Sabellek 3, B. Bruggenjurgen s, S. N. Willich 5, C. Vogelmeier6; IMedizinsche Klinik III, Mainz University Hospital, Mainz, GERMANY, 2Main- gau Hospital, Frankfurt, GERMANY. 3AstraZeneca, Wedel, GER- MANY, 4pulmonary Research Institute, GroBhansdorf, GER- MANY, 5Humboldt University, Berlin, GERMANY, 6Marburg University Hospital, Marburg, GERMANY.

3:45 230 Effect of Single-Dose Inhaled Steroid on Nocturnal Worsening

of Asthma E. O. Vianna, G. Frezza, J. A. B. Martinez, J. Terra-Filho; Depart- ment of Medicine, University of S. Paulo Medical School at RibeirS.o Preto, Ribeirao Preto, BRAZIL.

4.'0O 231 Asthmatics Treated with Preoperative Corticosteroids Have a

Low Incidence of Perioperative Complications F. W. Su, D. Beckman, N. Masur, C. Kabalin, P. Yarnold, L. Gram- mer; Northwestern University, The Feinberg School of Medicine, Chicago, IL.

O ra l Abs t rac t Session 2713

Saturday, March 8 2:15 PM to 4: l 5 PM

Genetics and Epidemiology of Allergic Diseases 2:15 232 -159 C to T Polymorphism of CD14 Is Associated with Non-

Atopic Asthma and Food Allergy J. G. Woo j, A. Assa'ad 2, A. Heizer 2, G. K. Khurana Hershey2; I Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati. Cincinnati, OH, 2Divi- sion of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati. OH.

2.'30 233 Association of Genetic Instability of Lymphocytes with

Increased IgE in Children Living in Areas of Belarus Contam- inated with Cs137 L. P. Titov I , D. Charnashey I, E. Kirylchyk I , P. Rytik I, S. Melnov ~, L. M. Du Buske 2, H. C. Schroder 3, W. Muller3; IRIEM, Minsk, BELARUS, 21mmunology Research Institute of New England, Fitchburg, MA, 31nstitute for Physiologische Chemic, Universitat Mainz, GERMANY.

2:45 234 The CDI4(C-159T) Polymorphism and Allergic Disease in

Afriean American Families E. Ehrlich, A. Zambelli-Weiner, M. Stockton-Porter, K. C. Barnes; Johns Hopkins University, Baltimore, MD.

Association of IL-4 Receptor Polymorphisms with Atopic Asth- ma in Korean Children S. Hong I, J. Kim j, B. Kim l, S. Choi 2. S. Lee2; IDepartment of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, REPUBLIC OF KOREA, 2Asan Institute for Life Sciences, Seoul, REPUBLIC OF KOREA.

3:00 235

$366 Abs t rac ts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

3:15 286

3:30 237

3:45 238

4:00 239

Stochastic Elements of Allergen-Specific Responses in Atopic Families D. R. Jackola, L. K. Mullany, C. L. Liebeler, M. N, Blumenthal, A. Rosenberg; Asthma & Allergy Program, University of Min- nesota, Minneapolis. MN.

Potential Genetic Markers for Latex Allergy R. H. Brown, R. G. Hamilton, M. Mintz, A. E. Jedlicka, S. R. Kleeherger; Johns Hopkins University, Baltimore, MD.

A Coding Region Single Nucleotide Polymorphism (C-SNP) of CD23 Is Associated with T Cell Response to Antigen J. Meng; Medicine, National Jewish Medical and Research Center, Denver, CO.

Socioeconomic Status and Race as Factors Contributing to Allergen Sensitization L. G. Jean t, E. Horowitz 1, D. Joyner 1, F. Malveaux 2, A. Togiasl; I Johns Hopkins University, Baltimore, MD, 2Howard University, Washington, DC.

Oral Abstract Session 2714


New Insights in Atopic Dermatitis 2:15 240 Effect of Neuropeptides on Cytokine Production in Peripheral

T Lymphocytes in Patients with Atopic Dermatitis in the Active Versus Inactive Phase C. Antfinez I , C. Mayorga I, J. L. Corzo 2, A. Vera 3, M. Blanca 4, L. F. Santamar/a-Babi ,~, A. Jurado 2, M. J. Torrest ; IResearch Labora- tory for Allergic Diseases, Carlos Haya Hospital, Malaga, SPAIN, 2Allergy Unit, Pediatric Department, Carlos Haya Hospital, Mala- ga, SPAIN, 3Dermatology Service, Carlos Haya Hospital, Malaga, SPAIN, 4La Paz Hospital, Allergy Service, Madrid, SPAIN, 5Almi- rail Prodesfarma Research Center, Barcelona, SPAIN.

2:30 241

2:45 242

3:00 243

3:15 244

Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin- 3 (NT-3) Inhibit Eosinophil Apoptosis in Atopic Dermatitis U. Raap t, N. Deneka I, H. Renz 2, A. Kapp t, B. Wedit; IDepartment of Dermatology and Allergology, Medical University of Hannover, Hannover, GERMANY, 2Department of Clinical Chemistry and Mol- ecular Diagnostics, University of Marburg, Marburg, GERMANY.

T Helper (Th) 2 Predominance in Atopy Is Due to Preferential Thl Memory/Effector Cell Apoptosis M. Akdis I, A. Trautmann I, S. Klunker I, I. Daigle t, U. C. Kucuk- sezer 2, W. Deglmann 3, R. Disch 3, K. Blaser 1, C. A. Akdisl; 1Swiss Institute of Allergy and Asthma Research (SIAF), Davos, SWITZERLAND, 2Institute for Experimental Medical Research, lstanbul, TURKEY, 3Clinic for Dermatology and Allergy, Davos, SWITZERLAND.

Variation of Gene Expression in PBMC After Stimulation with Staphylococcal Enterotoxin B (SEB) Among Dexamethasone and FK506 A. Akasawa; National Research Institute for Child Health and Development, Tokyo, JAPAN.

Tacrolimus Ointment Monotherapy Is Safe and Effective for the Long-Term Treatment (More Than 3 Years) of Atopic Der- matitis in Pediatric Patients J. M. Hanifin I , D. Y. Leung 2, A. Paller 3, J. Rico4; 1Department of Dermatology, Oregon Health Sciences University, Portland, OR,

3:30 245

3:45 246

4:00 247

2National Jewish Medical and Research Center, Denver, CO, 3Chil- dren's Memorial Hospital, Chicago, IL, 4Fujisawa Healthcare, lnc, Deerfield, IL.

Tacrolimus Ointment Does Not Alter Immune Responses of Eczematous Children E. R. Stiehm 1, R. L. Roberts 2, M. S. Kaplan 3, J. Corren4; qmmunology/Allergy/Rheumatology, University of California-Los Angeles, Los Angeles, CA, 2pediatrics, University of Califor- nia-Los Angeles, Los Angeles, CA, 3Allergy and Clinical Immunology, Kaiser Permanente, Los Angeles, CA, 4Allergy Research Foundation, Inc, Los Angeles, CA.

Actigraphy Assessment of Sleep Disturbance in Patients with Atopic Dermatitis B. G, Bender, S. B. Leung, D. Y. M. Leung; Pediatrics, National Jewish Med & Res Center, Denver, CO.

The Association of Cord IgE to Persistent Atopic Dermatitis in the First 2 Years of Life S. R, Morman 1, C. C. Johnson I, D. R. Ownby 2, S. M. Hensley Alford t, S. Havstad 1, E. M. ZorattiL; tHenry Ford Health System, Detroit, MI, 2Medical College of Georgia, Augusta, GA.



Animal Allergens Responsible for Inner-City and Occupational Asthma 2:15 248 Prevalence of Rat Allergen in Inner-City Homes and the Rela-

tionship to Sensitization and Asthma Morbidity 1". I". Perry I, T. Duong t , B. Merriman 2, P, A. EgglestonL; i Pediatric Allergy and Immunology, Johns Hopkins Hospital, Baltimore, MD, 2Bloomberg School of Public Health. Johns Hopkins Hospi- tal, Baltimore, MD.

2:30 249

2:45 250

3:00 251

3:15 252

Environmental Detection of Mouse Allergen by Immunoassay for Recombinant Mus m 1 A. Tsay t , E. Ferrari 2, P. Eggleston 3, A. Spisni 2, M. D. Chapmanl; qndoor Biotechnologies, lnc, Charlottesville, VA, 2University of Parma, Parma, ITALY, 3Johns Hopkins University, Baltimore, MD.

Occupational Exposure and Engineering Control Efficiency Assessment Using Airborne Mouse Urinary Protein (MUP) Analyses J. A. Schaefer, L. Marks, J. Bukowski, L. Dostillio, E. Bernacki, R. G. Hamilton; Johns Hopkins University School of Medicine, Baltimore, MD.

Airborne Endotoxin and Mouse Allergen Are Present on Dif- ferent Mass Particulates in Research Laboratories and Animal Rooms K. A. Pacheco I, C. S. Rose I, C. McCammon I, J. Martyny I, P. S. Thorne 2, M. E. O'Neill 2, A. H. Liu3; 1Occupational Medicine, National Jewish Medical and Research Center, Denver, CO, 2Occu- pational and Environmental Health, University of Iowa College of Public Health, Iowa City, IA, 3pediatrics, National Jewish Medical and Research Center, Denver, CO.

Cat and Dog Allergen Exposure in Homes with or without an Animal N. J. Custis I, J. A. Woodfolk 2, J. W. Vaughan 2, T. A. E. Platts- Mills2; t Allergy, University of Virginia, Charlottesville, VA, 2Uni- versity of Virginia, Charlottesville, VA.

J ALLERGY CLIN IMMUNOL Abs t rac ts $367 VOLUME 111, NUMBER 2

3:30 258

3:45 254

4:00

255

The Long-Term Effect of Environmental Control Measures on Mite, Cat, and Dog Allergen Levels A. Simpson, B. Simpson, M. Craven, A. Custovic, A. Woodcock; North West Lung Centre, Manchester, UNITED KINGDOM.

Relationship Between Exposure to Dust Mite, Cat, and Dog Allergens and Active Asthma in US Households S. J. Arbes, J r J, R. D. Cohn e, M. Yin 2, D. C. Zeldinl; INational Institute of Environmental Health Sciences, Research Triangle Park, NC, 2Analytical Sciences, Inc, Durham, NC.

The Relative Contributions of Indoor Pollutants and Allergens to Inner-City Childhood Asthma Morbidity E. C. Matsui, G. B. Diette, P. A. Eggleston; Johns Hopkins Uni- versity, Baltimore, MD.



Allied Health Abstracts." Food Allergy, Immunotherapy, Complementary/ Alternative Therapies, and Environmental Tobacco Exposure 2.'15 256 Parent and Adolescent Perceptions on Food Allergy

S, A. Noone j, A. Mufioz-Furlong 2, S. H. Sichererl; 1Pediatrics, Mount Sinai School of Medicine, New York, NY, eFood Allergy and Anaphylaxis Network, Fairfax, VA.

2:30 257

2:45 258

3:00 259

Is the Female Patient at Increased Risk for Systemic Reactions Caused by Immunotherapy? P. J. Sauber l, N. L. Ott2; tAllergy, Southdale Pediatrics, Edina, MN, 2Allergy, Southdale Pediatrics, Edina, MN.

The Use of Complementary Alternative Medicine Therapies for the Treatment of Asthma: Within the Inner City Minority Population J. T. Elliston I, G. Zuckerman 2, L. Bielory2; IMedicine, UMDNJ, Newark, N J, 2Medicine, UMDNJ, Newark, NJ.

Comparison of Home Assessment and Self-Report Measures of Environmental Tobacco Smoke in Children with Asthma J. M. Curtin-Brosnan I, P. A. Eggleston e, S. Kanchanaraksa I, R. A. Wood 2, C. S. Rand 2, G. B. Diette2; J Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, eJohns Hop- kins University, School of Medicine, Baltimore, MD.

Asthma Management 260 261

262

263

Poster Session 3501

Sunday, March 9 11:15 A M to 12:15 P M

Withdrawn Concomitant Occasional Use of Albuterol Influences: Bron- choprotective Responsiveness Afforded by Formoterol (FM) in Patients with the Giycine-16 Genotype E. J. Sims, B. J. Lipworth; Clinical Pharmacology & Therapeutics, University of Dundee, Dundee, UNITED KINGDOM. Risk Factors for Asthma Exacerbations: Is Asthma Severity a Predictor? D, A. Stempel l, P. Dorinsky 2, S. Yancey 2, A. Emmett 2, K. Rickard2; I University of Washington, Seattle, WA, 2GlaxoSmithK- line, Research Triangle Park, NC. Forced Oscillation Using Impulse Oscillometry (IOS) Provides Objective Responses to Inhaled Corticosteroids (HSS) in Asth-

matic Patients When FEV1 Fails to Improve E Gaylor 1,2, C. K. Saadeh l, M. Goldman 3, J. M. Matacara j, M. McGee 4, B. Reyesl; 1Amarillo Center for Clinical Research, Amarillo, TX, 2University of Arizona, Phoenix, AZ, 3Clinical Research Department, Drew University of Medicine, Los Angles, CA, 4Allergy ARTS, Amarillo, TX.

264 Forced Oscillation Using Impulse Oscillometry (lOS) Provides Objective Responses to Inhaled Corticosteroids (ICS) in COPD Patients When FEV1 Fails to Improve M. Goldman I, C. K. Saadeh 2, J. M. Malacara 2, M. McGee 3, P. Gay- 10r3,4; IClinical Trials Unit, Drew University of Medicine, Los Ange- les, CA, 2Amarillo Center for Clinical Research, Amarillo, TX, 3Allergy ARTS, Amarillo, TX, 4University of Arizona, Phoenix, AZ.

265 Forced Oscillation Using Impulse Oseiilometry (IOS) Detects False Negative Spirometry in Symptomatic Patients with Reac- tive Airways C. K. Saadeh 1,2, M. Goldman 3, P. Gaylor j,4` J. M. Malacara [.2, M. McGee I, M. Gaylor 2, C. SaadehS; ~Allergy ARTS, Amarillo, TX, 2Amarillo Center for Clinical Research, Amarillo, TX, 3Clinical Trials Unit, Drew University of Medicine, Los Angeles, CA, 4Uni- versity of Arizona, Phoenix, AZ, 5Allergy ARTS, Amarillo, TX.

266 HLA Association in ASA-Intolerant Asthma (AIA): DPBI*0301 as a Strong Marker in Korean Patients J, Choi; Allergy and Rheumatology, Ajou University School of Medicine, Suwon city, REPUBLIC OF KOREA.

267 Bronchial Challenge Tests in Asthmatics Sensitized to Cats: Influ- ence of the Particle Size on Systemic Inflammatory Markers F. Lieutier-Colas t , A. Purohi0, P. Meyer 2, A. Vero0, C. Sohy 1 , G, Pauli ~, F. de Blayl; JPulmonology, H6pitaux Universitaires de Strasbourg, Strasbourg, FRANCE, 2Biostatistique et Informatique Medicale, Facult6 de M6decine, Strasbourg, FRANCE.

268 Circadian Changes in the Sputum of Asthmatics and Healthy Controls T.A. Popov, M. S. Shenkada, A. V. Tzoncheva, M. P. Pravtchans- ka, T. B. Mustakov, M. P. Baleva; Medica[ University Sofia, Sofia, BULGARIA.

269 Urinary Eosinophilic Protein X, Sensitization and Symptoms of Allergic Disease C. Gore 1, P Kissen 1, B. M. Simpson I, C. Peterson e, A. A. Wood- cock I, A. CustovicE; I North West Lung Centre, Wythenshawe Hos- pital, Manchester, UNITED KINGDOM, apharmacia Diagnostics AB, Uppsala, SWEDEN.

270 Oscillometry in the Assessment of Small Airway Function in Asthma G, Gnanakumaran, D. MacLeod, P. Howarth, S. T. Holgate; Res- piratory Cell and Molecular Biology, University of Southampton, Southampton, UNITED KINGDOM.

271 Vascular Endothelial Growth Factor in Children with Lower Respiratory Tract Disease J. Shim, H. Jeong, M. Park, D. Keum; Pediatrics, Kangbuk Sam- sung Hospital, Seoul, REPUBLIC OF KOREA.

2"/2 Hydrofluoroalkane-134a Beclomethasone or Chlorofluorocar- bon Fluticasone: Effect on Small Airways in Poorly Controlled Asthma T. Thongngarm j,2, P. Silkofl ~, W. S. Kossack 3, H. S. Nelson2; I Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol Univer- sity, Bangkok, THAILAND, 2Medicine, National Jewish Medical and Research Center, Denver, CO, 3Biostatistics, National Jewish Medical and Research Center, Denver, CO.

273 Nasal Symptoms in Children with Bronchial Asthma S. Masuda I, T. Fujisawa 2, H. Katsumata 2, J. Atsuta 2, K. Iguchi 2, H. Kamiya2; IOtorhinolaryngology, National Mie Hospital, Tsu, JAPAN, 2pediatrics and Allergy, National Mie Hospital, Tsu, JAPAN.

274 Bronchial Reactivity as an Objective Marker for Childhood Asthma

S368 Abs t rac ts J ALLERGY CLIN IMMUNOL

FEBRUARY 2003

G, Phongsamart , N. Visitsunthorn, P. Vichyanond; Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, THAILAND.

275 Impaired Bronchodilator Responsiveness in Small Airways in Chronic Severe Asthma G. Gnanakumaran, D. MacLeod, P. Howarth, S. T. Holgate; Res- piratory Cell and Molecular Biology, University of Southampton, Southampton, UNITED KINGDOM.

276 The Differences in In Vitro Responses to D. farinae and Bronchial Hyperresponsiveness Among Subjects with or without Asthma A, Sutani, I. Kikuchi, K. Saito, N. Shimono, Y. Kuboshima, M. Nagata, Y. Sakamoto; Pulmonary Division, Second Department of Internal Medicine, Saitama Medical School, Saitama, JAPAN.

277 Is Rhinitis a Risk Factor for Severe Asthma in Children? D. Sol~, I. C. Camelo-Nunes, G. E Wandalsen, K. C. Melo, C. K. Naspitz; Pediatrics/Allergy, Universidade Federal de S~o Paulo, S~o Paulo, BRAZIL.

278 Validation of a New Lung Function Method in Orally lntubat- ed Mice Using a Model of Fungal Asthma A. Braun 1, M. Rott 1, T. Glaab 2, J. M. Hohlfeld 1, N. Krugk H. G. Hoymannl; lFraunhofer Institut Toxikologie und Aerosol- forschung, Pharmaforschung und Klinische Inhalation, Hannover, GERMANY, 2Medizinische Hochschule Hannover, Pneumologie, GERMANY.

279 What Proport ion of Childhood Asthma Is Attributable to Atopy? M. Mangat l, K. Williams 2, E. L. Peterson 3, E. M. Zoratti I , D. R. Ownby 4, C. C. Johnson3; IDivision of Allergy & Clinical Immunology, Henry Ford Hospital, Detroit, MI, 2Division of Gen- eral Medicine, Henry Ford Hospital, Detroit, MI, 3Biostatistics & Research Epidemiology, Henry Ford Hospital, Detroit, MI, 4Med- ical College of Georgia, Augusta, GA.

280 Pycnogenol in the Management of Asthma R. Farid j, S, Hosseini 2, R. Pishnamaz 3, R. R. Watson4; IDepart- ment of Allergy and Clinical Immunology, Mashad University of Medical Sciences, Mashad, IRAN (ISLAMIC REPUBLIC OF), 2The University of Arizona, Tucson, AZ, 3Department of Allergy and Clinical Immunology, Mashad, IRAN (ISLAMIC REPUBLIC OF), 4The University of Arizona, Tucson, AZ.

281 How Should Bronchial Hyperresponsiveness in Young Chil- dren with Recurrent Wheeze Be Measured? S. R. Shimamoto, S. M. Brugman, R. A. Covar, J. D. Spahn; Pedi- atrics, National Jewish Medical & Research Center, Denver, CO.

282 Childhood Asthma, Behavior Problems, and Family Functioning R. Calam i , L. Gregg I , B. Simpson 2, J. Morris 3, A. Woodcock ~-, A. Custovic2; t University of Manchester, Academic Division of Clin- ical Psychology, Manchester, UNITED KINGDOM, 2North West Lung Centre, Manchester, UNITED KINGDOM, 3Department of Medical Statistics, South Manchester University Hospitals NHS Trust, Manchester, UNITED KINGDOM.

283 Determinate the Sensitivity and Specificity Exercise Challenge on Forced Expiratory Volume 1 Second in Obese and Non Obese Children Compared with Asthmatic Children D. Blanca Estela i, J. Sienra-Monge 2, H. M. P. Maria de la paz3; iAllergy and Immunology, Hospital Infantil de M6xico Federico G6mez, Mexico city, MEXICO, 2Allergy and Immunology, Hospi- tal Infantil de Mexico Federico G6mez, Mexico City, MEXICO, 3Allergy and Immunology, Hospital Infantil de Mexico, Mexico City, MEXICO.

284 Low Prevalence of Exerclse-Indueed Bronchospasm in Rural High School Female Athletes M. E. Hurwitz l, J. G. Leflein I, M. A. Shinn t, E. 1. Soskolne 2, D. D. Chapman 2, A. K. Vanden Belt2; JRespiratory Medicine Research Institute of Michigan, Ypsilanti, MI, 2Pediatrics, St. Joseph Mercy Hospital, Ann Arbor, M1.

285 Increased Fall Versus Spring Asthma in Children in "Pasadena,

CA (1995-2001)--Possible Mechanisms J. B. Share 1, K. A. Portnoff 2, R. Goldweber 3, M. M. Glovskyl; IAsthma and Allergy Center, Huntington Memorial Hospital, Pasadena, CA, 2Rheumotology, Scripps Clinic, La Jolla, CA, 3Emer- gency Medicine, Huntington Memorial Hospital, Pasadena, CA.

286 Are Pollen Fragments Associated with Bronchial Asthma? P. E. Taylor l, R. C. Flagan j, A. MigueP, A. Olsen I, M. M. Glovsky2; IDly. Chemistry and Chemical Engineering, Caltech, Pasadena, CA, 2Asthma and Allergy Center, Huntington Medical Research Institute, Pasadena, CA.

287 There's a Bug in the System B. Wolf j, C. Schwindt 2, R. Hamilton 3, M. E. Bollinger2; 1Medi- cine, University of Maryland School of Medicine, Baltimore, MD, epediatrics, University of Maryland School of Medicine, Balti- more, MD, 3Allergy and Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, MD.

288 Psychometric Validation of a Patient-Based Preference Instru- ment: The Sensory Perceptions Questionnaire (SPQ) R. D. Lennox 1, I. Fowler t , M. Gore 2, K. C. Jones 3, N. Pethick 3, L. O'Dowd3; IPsychometric Technologies, Hillsborough, NC, 2Aval- on Health Solutions, lnc, Philadelphia, PA, 3AstraZeneca, Wilm- ington, DE.

289 Reliability and Validity of the Visual Analog Scale (VAS) for Use in Clinical Studies with Antihistamines: An Assessment of the Literature R. Shikiar i , D. Revicki 2, J. Isserman 2, M. J. Leahy 3, S. Meeves3; IMEDTAP International, Inc, Seattle, WA, 2MEDTAP Internation- al, Inc, Bethesda, MD, 3Aventis Pharmaceuticals, Bridgewater, NJ.

290 Allergy and Infectious Diseases in Athletes G. Lapucci j, G. Rasi 1, S. Bonini 1, on behalf of AIDA working group I, L. Aloe 1, B. Ambrosini 2, G. Berlutti 3, M. Boninik G. Cal- darone 3, G. Caselli 3, G. Colombo 3, A. Concu 2, G. S. Del Giacco 2, S. R. Del Giacco 2, A. Ghiani 2, R. Gaziani i , M. Lai 4, A. Lambiase i , E. Manca 2, P. E. Manconi 2, P. M. Matricardi i, T. Pamich 3, C. Rumi 4, A. Todaro 3, A. Torte I; l lnstitute of Neurobiology and Mol- ecular Medicine, CNR Italian National Research Council, Rome, ITALY, 2University of Cagliari, Cagliari, ITALY, 3Institute of Sports Science, Coni, ITALY, 4UCSC, Rome, ITALY.

291 Clinical Classification of Asthma, PEF and FEV1 A. G. Palma-Carlos t, M. L. Palma-Carlos2; Ilnstitute of Immunol- ogy, Lisbon University Hospital, Lisbon, PORTUGAL, 2Institute of Immunology, Lisbon University Hospital, Lisbon, PORTUGAL.

Poster Session 3502

Sunday, March 9 11:15 AM to 12:15 PM

Asthma Management: Bronchodilators, Anti-lgE, and Leukotriene Antagonists 292 IL-IBeta Attenuates the Preventive Effect of Beta-Agonlsts In

Vivo and In Vitro K. C. Hood; Medicine/Allergy, Creighton University, Omaha, NE.

293 Reduction in Asthma-Related Exacerbations and Exacerba- tion-Related Costs During Initial Maintenance Therapy with Fluticasone Propionate/Saimeterol Combination Product Ver- sus Montelukast or Flutieasone Propionate Alone R. Stanford, P. Dorinsky, C. Crim, S. Yancey, L. Edwards, K. Rickard; GlaxoSmithKline, Research Triangle Park, NC.

294 In Vitro Comparison of a Novel Nebulizer with Ultrasonic and Pneumatic Nebulizers J. B. Fink 1, M. Simon i, R. MacLaughlan 2, N. Behan2; IAerogen, Inc, Mountain View, CA, 2Aerogen Ireland, Galway, IRELAND.

295 Omalizumab Improves Symptom Control in Patients with Poorly Controlled Allergic Asthma and Concomitant Rhinitis J. Bousquet i , U. Harnest 2, K. E Chung 3, K. Oshinyemi 4, M. Blogg4; IService des Maladies Respiratoires, Montpellier, FRANCE, 2CLIN-


GUARD GMBH, Munich, GERMANY, 3National Heart and Lung Institute, Imperial College, London, UNITED KINGDOM, nNovartis Horsham Research Centre, Horsham, UNITED KINGDOM.

296 The Early Allergic Phase Is Better Controlled by Levoeetirizine than Desloratadine in a Nasal Provocation Test with Grass Pollen Allergen C. A. Deruaz, M. Berney, E. Monnier, A. Leimgruber, E Spertini; Division of Immunology and Allergy, Centre Hospitalier Universi- taire Vaudois (CHUV), Lausanne, SWITZERLAND.

297 Montelukast for Treating Seasonal Allergic Rhinitis: Effect of Pollen Counts in 3 Fall Studies M. E Malice, G. Philip, J. van Adelsberg, T. E Reiss; Merck & Co, Inc, Rahway, NJ.

298 Formoteroi (Foradil | Aerolizer | Protects Against Exercise- Induced Bronchoconstriction U. Yegen i, D. Till 2, B. Ziehmer I , J. Kottakis2; INovartis Pharma- ceuticals Corporation, East Hanover, N J, 2Novartis Horsham Research Centre, Horsham, UNITED KINGDOM.

299 Anti-IgE Therapy with Omalizumab Improves Asthma-Relat- ed Quality of Life of Patients with Poorly Controlled Allergic Asthma B. Higgins j, M. Britton 2, T. Carrillo 3, K. Oshinyemi 4, M. Blogg4; tDepartment of Respiratory Medicine, Sir William Leech Centre for Lung Research, Newcastle upon Tyne, UNITED KINGDOM, 2St. Peters Hospital, Chertsey, UNITED KINGDOM, 3Barranco de la Ballena s/n, Las Palmas de Gran Canarias, SPAIN, 4Novartis Horsham Research Centre, Horsham, UNITED KINGDOM.

300 The ASTHMA Survey: Impact of Montelukast on Symptoms in Mild to Modera te Persis tent Asthma and Exercise-Induced Asthma H. D. Malonne 1, A. Lachman 2, E Van den Brande3; iphysiology and Pharmacology, Free University of Brussels (ULB), Brussels, BELGIUM, 2Respiratory Disease, Moli~re-Longchamp Hospital, Brussels, BELGIUM, 3Respiratory Disease, AZ Sint-Maarten, Duffel, BELGIUM.

301 Effect of Omal izumab on Heal thcare Utilization in Patients with Moderate to Severe Allergic Asthma B. Chipps l, K. Kim 2, E Korenblat 3, Y. Deniz 4, B. Zheng 4, A. Car- roll4; JCapital Allergy, Sacramento, CA, 2West Coast Clinical Tri- als, Long Beach, CA, 3The Clinical Research Center, LLC, St. Louis, MO, 4Genentech, lnc, South San Francisco, CA.

302 Withdrawn 303 Virus Infection Reduces Theophylline Metabol ism in Acute

Asthma: Increased Lymphoid MxA Protein as a Marker for Viral Infection T. I tazawa 1, Y. Adachi 1, Y. S. Adachi l, J. Yamamoto I, M. Hamamichii, G. Murakami 2, T. Miyawakil; I Dpt of Pediatrics, Toyama Medical & Pharmaceutical University, Toyama, JAPAN, 2Dpt of Pediatrics, Toyama Red Cross Hospital, Toyama, JAPAN.

304 Low-Dose Inhaled Cortieosteroid (ICS) Confers Optimal Anti- Inflammatory Effects, While Additional Bronchodilator Activity Is Afforded by Salmeterol in Mild Persistent Asthmatic Children A. Mitra 1, E. J. Sims 2, S. Mukhopadhyay 1, B. J. Lipworth2; 1Child Health, University of Dundee, Dundee, UNITED KINGDOM, 2Clinical Pharmacology & Therapeutics, University of Dundee, Dundee, UNITED KINGDOM.

305 Evaluat ion of Efficacy and Pat ient Preference of Albuterol Delivered via the PoeketChamber (PC) Versus the AeroCham- ber (AC Plus) in Patients with Asthma M. J. Welch, C. Gallet, N. K. Ostrom, E. O. Meltzer; Allergy and Asthma Medical Group and Research Center, San Diego, CA.

306 The Efficacy of Montelukast as an Additive and Steroid Spar- ing Agent in Children with Asthma Previously Maintained on Inhaled Corticosteroid Therapy W. Phipa tanakul i, C. Greene 2, S. Downes 1, B. Cronin 1, L. Schneider I, A. lrani2; IAllergy and Immunology, Children's Hos-

pital, Boston, Harvard Medical School, Boston, MA, 2Allergy and Immunology, Medical College of Virginia, Richmond, VA.

307 The Effects of Histamine and Leukotriene Receptor Antago- nism on Nasal Mannitol Challenge in Allergic Rhinitis R. D. Gray l, D. K. C. Lee I, K. Haggart 1, G. P. CurriO, S. D. Anderson :~, B. J. LipworthJ; IAsthma and Allergy Research Group, Dundee, UNITED KINGDOM, eRoyal Prince Alfred Hospital, New South Wales, AUSTRALIA.

308 Flexible Dosing of Monte lukas t for Trea tment of Seasonal Allergic Rhinitis: Morning or Evening J. van Adelsberg, G. Philip, J. Menten, M. P. Malice, T. E Reiss; Merck & Co, Inc, Rahway, NL

309 Montelukast Confers Complimentary Non-Steroidal Anti- Inflammatory Activity in Asthmatics Receiving Fluticasone Alone and Fluticasone/Saimeterol Combination G. P. Currie, D. K. Lee, K. Haggart, C. E. Bates, B. J. Lipworth; Asthma & Allergy Research Group, Ninewells Hospital & Medical School, Dundee, UNITED KINGDOM.

310 Omalizumab Does Not Induce Thromboeytopenia in the Treat- ment of Asthma E. IsraeP, J. Cohn 2, E. Meltzer 3, J. McCarty 4, B. Zheng 4, A. Car- roll4; 1Brigham and Women's Hospital (Asthma Research Center), Boston, MA, 2Asthma, Allergy, and Pulmonary Associates, Philadelphia, PA, 3Allergy & Asthma Medical Group & Research Center, A.P.C., San Diego, CA, 4Genentech, lnc, South San Fran- cisco, CA.

311 Montelukast, a Leukotriene Receptor Antagonist, Significantly Improves Symptoms of Seasonal Allergic Rhinitis: Analysis of 5 Spring and 2 Fall Studies G. Philip, M. P. Malice, J. Menten, J. van Adelsbcrg, T. E Reiss; Merck & Co, Inc, Rahway, NJ.

312 Montelukast as Controller Monotherapy for Canadian Pedi- atric Asthma Patients D. B~rub~, for the STAR investigators; H6pital Ste-Justine, Uni- versit6 de Montr6al, Montr6al, PQ, CANADA.

313 Topical Nebulized Montelukast for Nasal Polyps S. L. Speetor 12, R. A. Tan 2, A. Otsuji 3, N. Attiah 2, J. Moreno e, L. Patrimonio2; IDepartment of Medicine, UCLA Medical Center, Los Angeles, CA, eCalifornia Allergy & Asthma Medical Group, Inc, Los Angeles, CA, 3SinusPharmacy, Carpenteria, CA.

314 Patient Perceptions of an Inhaled Asthma Medication Admin- istered as an Inhalation Powder via the Diskus or as an Aerosol via a Metered Dose Inhaler K. K. Sbeth I, W. R. Lincourt 2, L. D. Edwards 2, E Dorinsky:, C. Crim2; JArnett Clinic, Lafayette, IN, 2GlaxoSmithKline, Research Triangle Park, NC.

315 Nebulized Combined Formoterol and Budesonide (NCFB) for Children Younger than 5 Years of Age with Persistent Asthma S. Ting I. 1. Cisnero2; ~Pediatrics, Texas Tech University, El Paso, TX, 2Allergy & Asthma Center of the Southwest, Las Cruces, NM.

316 Infliximab Therapy for Severe Steroid-Dependent Asthma and COPD: A Case Report D, L. Gossage, L. M. Livingston; The Allergy, Asthma & Sinus Center, Knoxville. TN.

Poster Session 3503


Cytokines and Chemokines, Signaling 317 A Direct Interaction Between Clara Cell Secretory 10 KD Pro-

tein (CCI0) and Inflammatory Cell Types B. Plunkett 1, B. Chowdhury 2, Z. Zhang 2, S. K. HuangJ; qohns Hopkins University, Baltimore, MD, 2National Institutes of Health, Rockville, MD.

S 3 7 0 A b s t r a c t s J ALLERGY CLIN IMMUNOL FEBRUARY 2003

318 Functional Analysis of the Chemokine Receptor CCR3 on Air- way Epithelial Cells C. Stellato I, B. Tancowny I, M. E. Brummet 1, S. L. Curry j, C. E. Austin 2, L. A. Becki; JDivision of Clinical Immunology, Johns Hopkins University, Baltimore, MD, gAstraZeneca, R&D Charn- wood, Loughborough, UNITED KINGDOM.

319 Soluble Recombinant Human Interleukin-4 Receptor (rhulL- 4R) Inhibition of T Lymphocytes from Antigen-Specific Cell Lines and Segmental Allergen Challenges J.A. NegrP, J. W. SteinkO, R. Enelow 2, D. F. Baramki t , L. BorishJ; t Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, 2Pulmonary and Critical Care Medi- cine, University of Virginia Health System, Charlottesville, VA.

320 Human B Lymphocytes Produce IL-13: Role Asan Autocrine Cytokine in IgE Synthesis R. Janani j, O. Hajoui j,2, T. Ronis ~, Q. Hamid j, B. D. MazerL2; tMeakins Christie Laboratories, McGill University, Montreal, PQ, CANADA, 2Division of Allergy and Immunology, Montreal Chil- dren's Hospital, Montreal, PQ, CANADA.

321 Molecular Mechanism of IL-5 Receptor Proteasome Degradation M. Martinez-Moczygemba; Medicine/Immunology, Baylor Col- lege of Medicine, Houston, TX.

322 Concerted Expression of Eotaxin-1, Eotaxin-2, and Eotaxin-3 in Human Bronchial Epithelial Cells A. Komiya I , H. Nagase 1, H. Yamada 2, T. Sekiya I , M. Yamaguchi I , Y. Sano 2 , N. Hanai 3, A. Furuya 3 , K. Ohta 4, O. Yoshie 5 , K. Yamamoto j , K. HiraiJ; IUniv. of Tokyo Graduate School of Medicine, Tokyo, JAPAN, 2Doai Memorial Hospital, Tokyo, JAPAN, 3Kyowa Hakko Kogyo, Tokyo, JAPAN, 4Teikyo University School of Medicine, Tokyo, JAPAN, 5Kinki University School of Medicine, Osaka, JAPAN.

323 Demonstration of Interleukin-9 Receptor Function in Human Germinal Center B Cells L. M. Fawaz j, X. Li 1, Q. A. Harold 2, B. Mazerl; JAllergy and Immunology, Montreal Children Hospital Research Institute and Meakins Christie Laboratories, Montreal, PQ, CANADA, 2Depart- ment of Pathology, Meakins Christie Laboratories, McGill Univer- sity, Montreal, PQ, CANADA.

324 Multiple Defensins Present in Human Breast Milk M. D. Srivastava 1, S. A. Armogida 2, A. Melton2; IDepartment of Pediatrics, Metrohealth Medical Center, Cleveland, OH, 2Depart- ment of Allergy and Immunology, Cleveland Clinic Foundation, Cleveland, OH.

325 Activation of Human Eosinophils by CC Chemokine Eotaxin Is Inhibited by Gelatinase B (MMP-9) T. Dworok, C. Hartmann, A. Kapp, H. Petering; Hannover Medical University, Hannover, GERMANY.

326 Albuterol Increases IL-4 Production by Ragweed-Stimulated Peripheral Blood Mononuclear Cells S. Drapkin, G. Li, J. N. Moy; Rush Medical College and Cook County Hospital, Chicago, IL.

327 A Novel Method for the Assessment of Intracellular STAT 6 Phosphorylation by Flow Cytometry B. D. Mazer 1,2, X. Li 1.2, R. Jananil,2; I Meakins Christie Laborato- ries, McGill University, Montreal, PQ, CANADA, 2Division of Allergy and Immunology, Montreal Children's Hospital, Montreal, PQ, CANADA.

328 Regulation of IL-13 mRNA Expression in Human B Lymphocytes O. Hajoui 1,2, P. Joubert I, R. Janani 1, Q. Hamid I, B. D. Mazerl,2; I Meakins Christie Laboratories, McGill University, Montreal, PQ, CANADA, 2Division of Allergy and Immunology, Montreal Chil- dren's Hospital, Montreal, PQ, CANADA.

329 NGF and TrkA Expression in Human Cord Blood CD34 Posi- tive Cells A. Procoli t , L. Bracci-Laudiero I , D. Celestino 2, C. Rumi 3, A. Picar- di 4, S. Bonini I, L. Aloe i; qnstitute of Neurobiology and Molecular Medicine, CNR, Rome, ITALY, 2Department of Medical Therapy, University of Rome, La Sapienza, Rome, ITALY. 3Department of

Hematology, University Cattolica, Rome, ITALY, 4Department of Hematology, University of Rome Tor Vergata, Rome, ITALY.

330 Dendritic Cell Homing to Murine Lung Is Not CCL5 or CCR5 Dependent M. H. Grayson 1, M. M. Rohlfing I, M. J. Holtzman2; qnternal Medicine; Division of Allergy and Immunology, Washington Uni- versity School of Medicine, Saint Louis, MO, 2Internal Medicine; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, MO.

331 The Innate Immune System in Human Breast Milk N. Yannaras, M. Srivastava; Pediatrics, Metrohealth Medical Cen- ter, Cleveland, OH.

332 LPS Stimulates T Cell Proliferation and Expression of IL-10 in the Nasal Mucosa of Young Atopic Children but not in Atopic Adults M. K. Tulic 1, J. J. Manoukian 2, D. H. Eidelman l, Q. Harold1; IMeakins-Christie Laboratories, McGill University, Montreal, PQ, CANADA, 2Montreal Children's Hospital, Montreal, PQ, CANADA.

333 Monophosphoryl Lipid A: In Vitro Effects on Human T Cells Proliferation and Cytokines Production E Puggioni j, J. N. Francis 2, S. R. Durham2; 1University of Pavia, Department of Pulmonary Diseases, IRCCS Policlinico S. Matteo, Pavia, ITALY, 2Upper Respiratory Medicine, Imperial College, London, UNITED KINGDOM.

334 Cytokine Secretion by Activated T Cells Is Dependent on Mul- tidrug Resistance Protein-1 (MRP-1) R. L. Rabin, M. A. Alston, H. Huang, J. E. Slater; Center for Bio- logics Evaluation and Research, US Food and Drug Administra- tion, Rockville, MD.

335 Norepinephrine (NE) Increases the Susceptibility of Thermally Injured Mice (TI-Mice) to Sepsis Through the Inhibition of CC Chemokine Ligand 3 (CCL3/Macrophage Inflammatory Pro- tein let) Production H. Takahashi I , M. Kobayashi 1, D. N. Herndon j , R. B. Pollard 2, E Suzukil; iThe University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX, 2University of Cali- fornia Davis Medical Center, Sacramento, CA.

336 The Recombinant IL-8 Stimulates the Migration of Neu- trophils but not Eosinophils into Nasal Lavage Fluid P. G6rski, M. Kupczyk, M. Bochenska-Marciniak, P. Kuna; Department of Medicine Medical University of Lodz, Division of Pneumonology and Allergy, Lodz, POLAND.

33"/ Tissue Evidence for a Th2-type Immune Response in the Meningeal Compartment to Bovine Pericardium Heterograft Following Dural Repair for Arnoid-Chiari Malformation Uti- lizing CD Markers B. B. Faltay i, M. R. Murali 2, B. A. Silverman I, A. T. Schneiderl; I Allergy & Immunology, Long Island College Hospital, Brooklyn, NY, 2Allergy and Immunology, Massachusetts General Hospital, Boston, MA.

338 Expression and Regulation of IL-13Rff2 on Human (Tonsillar) B Cells S. Z. AI-Muhsen 1,2, O. Hajoui 2, P. Joubert 2, Q. Hamid 2, B. Mazerl,2; IDivision of Allergy and Clinical Immunology, Montreal Children Hospital, McGill University, Montreal, PQ, CANADA, 2Meakins- Christie Laboratories, McGill University, Montreal, PQ, CANADA.

339 Critical Role of P38 Mitogen-Activated Protein Kinase in Virus and DsRNA Induction of Proinflammatory Cytokines in Human Bronchial Epithelial Cells E Imani 1, T. R. Meusel2; qohns Hopkins University, Baltimore, MD, 2Medicine, Johns Hopkins University, Baltimore, MD.

340 Characterization of Fibroblasts Derived from Nasal Polyp and Control Tissue L. Borish J, J. W. Steinke I , K. Roelofs 1 , C. D. Crouse 2, D. Bradley 2, S. Kountakis2; IAsthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, 2Otolaryngology, Uni- versity of Virginia Health System, Charlottesville, VA.


Poster Session 35O4


Contact Dermatitis 34"1 Airborne Contact Dermatitis Due to Ambrosia Deltoidea: A

Role for Air Sampling? M. J. Schumacher, N. Silvis; University of Arizona, Tucson, AZ.

342 Contact Sensitization to Euro Coins U. Amon, P. J. Preinfalk; PsoriSol Center for Dermatology and Allergy, Hersbruck, GERMANY.

343 Lansoprazole Induced Contact Dermatitis G. E. Akan, M. H. Moss; Allergy and Immunology, University of Wisconsin Hospital and Clinics, Madison, WI.

344 A Type IV Hypersensitivity Reaction to Pantoprazole B. P. E Yolanda; Allergy, H.G.U. Gregorio Marafi6n, Madrid, SPAIN.

345 Textile---Dye Allergic Contact Dermatitis H. D. Oei 1, W. L. Kartanegara I, R. L. Oei2; IAllergology, Albert Schweitzer Hospital, Dordrecht, NETHERLANDS, 2Medicine, University of Maastricht, Maastricht, NETHERLANDS.

346 Ulcerating Allergic Contact Dermatitis Around Colostomy in a Patient with Morbus Crohn S. M. Fischer, V. Grimm, A. Gauger, E M. K6hn, J. Rakoski, J. Ring; Department of Dermatology and Allergy Biederstein, Tech- nical University, Munich, GERMANY.

Poster Session 3505


Atopic Dermatitis 347 Physical and Psychosocial Functioning of Children with Atopic

Dermatitis A. S. Kaugars, M. D. Klinnert, M. Price, M. L. Polintan, E M. Atkins, D. L. Bratton; National Jewish Medical and Research Cen- ter, Denver, CO.

348 Patients with Severe Atopic Dermatitis Benefit from Tacrolimus Ointment Monotherapy L. Schneider j, W. Berger 2, M. Rico3; tAllergy and Immunology Program, Children's Hospital, Harvard Medical School, Boston, MA, 2Southern California Research Center, Mission Viejo, CA, 3Fujisawa Healthcare, lnc, Deerfield, IL.

349 Tacrolimus Ointment Monotherapy Is a Safe and Effective Treatment for Mild Atopic Dermatitis J. M. SpergeP, B. M. Prenner 2, J. Rico3; IChildren's Hospital of Philadelphia, Philadelphia, PA, 2Allergy Associates Medical Group, Inc, San Diego, CA, 3Fujisawa Healthcare, Inc, Deerfield, IL.

350 The Effect of Pimecrolimus on Prick Skin Testing E. E. Chang 1, J. M. EI-Dahr2; IClinical Immunology, Allergy and Rheumatology, Tulane University Health Science Center, New Orleans, LA, 2Section of Clinical Immunology, Allergy and Rheumatology, Tulane University Health Science Center, New Orleans, LA.

35"1 Atopic Eczema/Dermatitis Syndrome in South Europe--How Important is Food Allergy? S. Prates, E. Pargana, M. Borrego, S. Oliveira, C. Santa-Marta, J. Rosado-Pinto; Immunoallergy Department, D. Esteffinia Hospital, Lisbon, PORTUGAL

352 Atopic Dermatitis as an Allergic Marker for Irritable Bowel Syndrome P. J. Bansal t, B. Moparty 2, M. T. DeMeo 2, A. Farhadi 3, A. Keshavarzian 2, M. C. Tobin4; llmmunology/Microbiology, Rush- Presbyterian St. Luke's and Cook County Hospitals, Chicago, IL, 2Department of Internal Medicine, Rush-Presbyterian St. Luke's Hospital, Chicago, IL, 3Department of Internal Medicine, Rush-

353

354

Presbyterian St. Luke's Hospital, Chicago, IL, 4Department of Immunology/Microbiology and Internal Medicine, Rush-Presby- terian St. Luke's and Cook County Hospitals, Chicago, 1L. Clinical Characteristics of Atopic Dermatitis in a Group of Patients of Monterrey, Mexico M. E. M, Elias; Centro Regional de Alergia e Inmunologia Clini- ca, Hospital Universitario, Monterrey, MEXICO. In Vivo Cytokine Patterns and Activation Markers in Adult Patients with Acute and Chronic Atopic Dermatitis J. L. Corzo l, C. Antdnez 2, M. J. Tones 2, C. Mayorga 2, R. Santos ~ , M. Blanca 3, A. Jurado I, L. E Santamarfa-Babi4; IAllergy Unit, Pedi- atric Department, Carlos Haya Hospital, M~ilaga, SPAIN, 2Research Laboratory for Allergic Diseases, Carlos Haya Hospital, M~ilaga, SPAIN, 3Allergy Service, La Paz Hospital, Madrid, SPAIN, 4Almi- rail Prodesfarma Research Center, Barcelona, SPAIN.

Poster Session 3506


Asthma Epidemiology and Risk Factors 355 Asthma Phenotypes at Age 4: Follow-up of Disadvantaged

Wheezing Infants M. D. Klinnert I, M. R. Price 2, A. H. Liu I, C. A. Dennisl; tPedi- attics, National Jewish Medical and Research Center, Denver, CO, 2Pediatrics, National Jewish Medical and Research Center, Denver, CO.

356 Forecasting Asthma-Related Healthcare Utilization with Daily Virus and Allergen Measures: A 3-Year Study M. W. McClung 1,2, A. H. Liu 2,3, R. H. Jones 2, R. L. Vogt 2,4, A. J. Davidsonl,2; IDenver Public Health, Denver, CO, 2University of Colorado Health Sciences Center, Denver, CO, 3National Jewish Medical & Research Center, Denver, CO, 4Tri-County Health Department, Greenwood Village, CO.

357 Rhinitis-Asthma and Aeroallergen Pattern in the Last Five Year at the Outpatient Clinic of the Institute of Immunology, Caracas, Venezuela J. V. Garmendia 1, P. Tassinari 2, O. Aldrey 2, L. Davila 2, B. Durante 2, D. Galante 2, N. E. Bianco2; qnstituto de lnmunologia, Universidad Central de Venezuela, Caracas, VENEZUELA, 21nsti- tuto de Inmunologia, Universidad Central de Venezuela, Caracas, VENEZUELA.

358 Hospitalizations for Asthma During Childhood: What Percent- age of Those Admitted Have Had Their Allergic Status Defined D. D. Murphy I , H. T. Carper l, E. A. Erwin I, A. P. McLaughlin I , M. S. Shaker M. A. Hellems I, T. A. E. Platts-Mills 2, P. W. Hey- mann J; tPediatrics, University of Virginia, Charlottesville, VA, 21nternal Medicine, University of Virginia, Charlottesville, VA.

359 Asthma in Puerto Rico E. R. Bleecker ~ , R. Perez-Perdomo 2, J. Arvizu 3, S. Howard I , D. A. Meyersl; ICenter for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 2University of Puerto Rico, San Juan, PR, 3GlaxoSmithKline, San Juan, PR.

360 Fatal Asthma in an Urban Population--Preliminary Findings of a Retrospective Study P. C. Tolomeo I, M. Polansky 2, M. Sherman 3, D. Lang4; tThomas Jefferson University, Philadelphia, PA, 2School of Public Health, Drexel University, Philadelphia, PA, 3School of Public Health, Drexel University, Philadelphia, PA, 4Cleveland Clinic Foundation. Cleveland, OH.

361 High Medication Usage in a Large Cohort of Patients with Severe or Difficult-to-Treat Asthma C. Johnson 1, B. E. Chipps 2, C. M. Dolan I, E. H. Warrenl; tGenen- tech, Inc, South San Francisco, CA, 2Capitol Allergy and Respira- tory Disease Center. Sacramento, CA.

$372 A b s t r a c t s J ALLERGY CLIN IMMUNOL FEBRUARY 2003

362 ISAAC in Hanoi, Vietnam: 1999-2002 S. K. Chai t, N. N. Nga 2, H. Checkoway 1, T. T. Binh 2, T. K. Takaro I , G. J. Redding 3, D. K. Van 2, P. H. Son 2, M. C. Keifer I , L. V. Trung 2, S. Barnhart4; 1Department of Environmental Health, University of Washington, Seattle, WA, 2National Institute of Occupational and Environmental Health, Ministry of Health, Hanoi, VIETNAM, 3Department of Pediatrics, Division of Pul- monary Medicine, University of Washington, Seattle, WA, 4Har- borview Medical Center, University of Washington, Seattle, WA.

363 Atopic Disease in Children with Elevated Serum Lead Levels K. Shaw l, J. N, Moy 2, K. Amin 3, B. yu4; IAIlergy/Immunology, Rush-Presbyterian-St. Luke's/Cook County Hospital, Chicago, IL, 2Allergy/lmmunology, Rush-Presbyterian-St. Luke's/Cook County Hospital, Chicago, IL, 3Mt, Sinai Medical Center, Chicago, IL, 4Allergy/Immunology, Rush-Presbyterian-St. Luke's/Cook County Hospital, Chicago, IL.

364 Risk Factors for Asthma in Kuwaiti School Children M. AI-Mousawil, H. Lovel 2, A. Kheder 3, N. Behbehani 3, N. Arifhodz- ic 4, A. R. Al-Dowaisan 4, A. Woodcock 1, A. Custovicl; INorth West Lung Centre, Manchester, UNITED KINGDOM, 2University of Man- chester, Manchester, UNITED KINGDOM, 3University of Kuwait, Kuwait, KUWAIT, 4AI-Rashid Allergy Centre, Kuwait, KUWAIT.

365 Symptoms in Atopic and Non-atopic Children with Asthma E. Simons I , J. Brosnan I , R. Wood 1 , C. Rand 2, S. Kanchanaraksa 3 , L. Schwarz 1, N. Durkin 1, P. A. Egglestonl; IDepartment of Pediatrics, The Johns Hopkins University, Baltimore, MD, 2Department of Med- icine, The Johns Hopkins University, Baltimore, MD, 3Department of Epidemiology, The Johns Hopkins University, Baltimore, MD.

366 Sensitization to Indoor Allergens in Patients with Cockroach Asthma and Rhinitis in Belarus L. Litvyakova I, G. Lugovtsova 2, J. A. Bellantil; 1Georgetown University, Washington, DC, 2Allergy Center, Vitebsk, BELARUS.

367 Nocturnal Cough: Is It Allergic Rhinitis or/and Asthma? T. N. Tan, D. Y. T. Goh, L. P. C. Shek, F. T. Chew, B. W. Lee; National University of Singapore, Singapore, SINGAPORE.

368 Risk Factors of Atopic Diseases on the Basis of Epidemiological Study in Lodz Province (Poland) I. Kuprys, A. Elgalal, B. Korzycka-Zaborowska, M. Kupczyk, P. Gorski, P. Kuna; Department of Pneumonology and Allergy, Med- ical University, Lodz, POLAND.

369 Childhood Asthma, Allergic Rbinoconjunctivitis, and Atopic Eczema Prevalence in Yugoslavia Z. M. Zivkovic 1, S. S. Zivanovic 2, M. Hadnadjev3; 1Pediatric Pul- monology, Children's Hospital for Lung Diseases, Belgrade, YUGOSLAVIA, 2pediatric Pulmonology, Children's Clinic Nis, Nis, YUGOSLAVIA, 3Health Care Center Novi Sad, Novi Sad, YUGOSLAVIA.

370 Factors Evoke Status Asthmaticus and Changes in Physical Examination in Admission to ICU: 10 Years' Experience K, J. Karwat, R. Chazan; Pneumonology, Warsaw Medical Uni- versity, Warsaw, POLAND.

371 Capsaicin Cough Challenge During Acute Allergen-Induced Asthma Allows Continued Spontaneous Recovery of FEV1 D, J. Weinfeld; Department of Respiratory Medicine and Allergol- ogy, Allergy Centre, Sahlgrenska, Gothenburg, SWEDEN.

Poster Sess ion 3507


Immune Response to Inhaled Allergens 372 The Der p 2 Recombinant Variant C21S/C73S Has Reduced

Binding to IgE and to Monoclonal Antibody Alpha-DpX R. B. Gore, M. Craven, E I. Smillie, A. Custovic, A. Woodcock; Wythenshawe Hospital, North West Lung Centre, Manchester, UNITED KINGDOM.

373 Genetic Relationship Between Allergy-Causing Dust Mites: Phyiogenetic Inference From Random Amplified Polymorphic DNA (RAPD) Markers, Housekeeping Gene (18S rDNA), and Group 2 Allergens A. H. B. Loo, S. P. L. Tan, A. C. Angus, K. T. Kuay, K. Reginald, Y. F. Gao. E T. Chew; National University of Singapore, Singa- pore, SINGAPORE.

374 Immonogenicity of Allergen Encapsulated into Various Hydroxyapatite-Polysaccharide Granules A. A. Babakhin t, E. A. Krylova 2, A. A. Vedernikov i, L. M. Du Buske3; iNational Research Center-Institute of immunology, Moscow, RUSSIAN FEDERATION, 21nstitute for General and Inorganic Chemistry, Moscow, RUSSIAN FEDERATION, 3Immunology Research Institute of New England, Fitchburg, MA.

375 Cross-Reactive lgE Epitopes of Bet v 1 and Homologous Food Allergens Identified by Site-Directed Mutagenesis M. Wallner t, A. PrliO, B. Kramer I, H. Breiteneder 2, K. Hoff- mann-Sommergruber 2, E Ferreiral; qnstitute of Genetics, Univer- sity of Salzburg, Salzburg, AUSTRIA, 2Department of Pathophys- iology, University of Vienna, Vienna, AUSTRIA.

376 Increased Production of IL-5 and IFN- 7 in Response to Rat Urine in Individuals with Laboratory Animal Allergy H. L. Jeal, M. G. Jones, A. Draper, P. Cullinan, A. Newman Tay- lor; Occupational and Environmental Medicine, Imperial College at NHLI, London, UNITED KINGDOM.

377 Differences in Circulating Dendritic Cell Subtypes in Cord Blood and Peripheral Blood of Healthy and Allergic Children M. M. Hagendorens I, D. G. Ebo 2, A. J. Schuerwegh 2, A. Huy- brechs L, H. P. Van Bever j, C. H. Bridts 2, L. S. De Clerck 2, W. J. Stevens2; IPediatrics and Immunology, University of Antwerp, Antwerpen, BELGIUM, 2Immunology-Allergology-Rheumatol- ogy, University of Antwerp, Antwerpen, BELGIUM.

378 Tropomyosin in Ascaris Lumbricoides: A Cross-Reactive IgE Binding Protein? L. K. Arruda I , A. B. R. Santos I , V, S. E Sales 2, V. P. L. Ferriani I , V. C. R. Dantas 2, C. E. B. Rodrigues 2, R. E. Esch 3, M. D. Chapman4; tUniversity of S~o Paulo, Ribeirao Preto, BRAZIL, 2Federal Uni- versity of Rio Grande do Norte, Natal, BRAZIL, 3Greer Laborato- ries, Lenoir, NC, 4Indoor Biotechnologies lnc, Charlottesville, VA,

379 Cross-Reactive Carbohydrate Determinants (CCD): Mimick- ers of Allergy C. H. Bridts, D. G. Ebo, M. M. Hagendorens, L. S. De Clerck, W. J. Stevens; Immunology-Allergology-Rheumatology, University of Antwerp, Antwerpen, BELGIUM,

380 Immunodominant Epitope of Lipocalin Allergen Bus d 2 Is Suboptimal for Human T Cells T. Kinnunen t , C. Buhot 2, A. N~irv~inen 3, M. Rytk6nen-Nissinen 1, S. Saarelainen t, S. Pouvelle-Moratille 2, J. Rautiainen I, A. Taivainen 4, B. Maillere 2, R. Mfintyj~irvi I, T. Virtaneni: IDepart- ment of Clinical Microbiology, University of Kuopio, Kuopio, FINLAND, 2D6partement d'lng6nierie et d'Etudes des Prot6ines, Commissariat ~t l 'Energie Atomique-Saclay, Gif sur Yvette, FRANCE, 3Department of Chemistry, University of Kuopio, Kuo- pio, FINLAND, '*Department of Pulmonary Diseases, Kuopio Uni- versity Hospital, Kuopio, FINLAND.

381 Extensive Sharing of Epitopes Between Group I Allergens of Cedar Pollen T. Midoro-Horiuti 1, V. Mathura t, C. H. Schein I, W. Braun t, A. Togawa j , T. Oka 2, M. Watanabe 3, E. G. Brooks I , R. M. Goldbluml; IUniversity of Texas Medical Branch, Galveston, TX, 2Oka Phar- macy, Tamano, JAPAN, 3Tokyo Research Laboratories, Kowa Co, Ltd, Tokyo, JAPAN.

382 A 4-Year Review of Aeroallergen lmmunotherapy Reactions C. N. Webb I, J. M. Quinn 2, N. Greene3; IAllergy/Immunology, Wilford Hall Medical Center, Lackland AFB, TX, 2Allergy/ Immunology Department, Wilford Hall Medical Center, Lackland

d ALLERGY CLIN IMMUNOL Abst rac ts $373 VOLUME 111, NUMRER 2

AFB, TX, 3Department of Internal Medicine, Wilford Hall Medical Center, Lackland AFBt, TX.

383 Horseradish Peroxidase Skin Test Reactivity in Cross-Reactive Carbohydrate Determinants--IgE Positive Subjects A. Marl; Allergy Unit, National Health Service, Rome, ITALY.

384 Antibody Responses to Intranasal and Intraperitoneal Natural Rubber Latex in BALB/c Mice T. Yan I, S, J. McGeady2; ]Pediatrics, A. I. duPont Hospital for Children, Wilmington, DE, 2Pediatrics, Thomas Jefferson Univer- sity, Philadelphia, PA.

385 Systemic Exposure of Mice to Respiratory Sensitizing Proteins: Induction of IgE R. J. Dearman I, D. A. Basketter 2, K. Sarlo 3, I. Kimberl; ]Syn- genta CTL, Macclesfield, UNITED KINGDOM, 2SEAC Unilever Colworth Laboratories, Sharnbrook, UNITED KINGDOM, 3proc- ter & Gamble Miami Valley Laboratories, Cincinnati, OH.

386 Effect of Escalating Doses of Inhaled LPS on Markers of Air- ways Inflammation and Innate Immunity in Healthy Volunteers N. E, Alexis; Pediatrics, UNC, Chapel Hill, NC.

387 Identification, Cloning, and Expression of a Major Component of the House Dust Mite Proteome, a Putative Cuticle-Like Pro- tein, via Peptide Mass Fingerprinting, Tandem Mass Spec- trometry, and Contiguous Expressed Sequence Tag Alignments X. Z. Bi, S, T. Ong, E T. Chew; Department of Biological Sci- ences, National University of Singapore, Singapore, SINGAPORE.

388 The Effects of Lipopolysaccharide (LPS) on Immune Respons- es in C57BL/6 Mice C. Valerio, J. E. Slater; Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD.



Drug Allergy 389 Intravenous Immunoglobulin (IV1G)-Associated Thromboem-

bolism in Antibody Deficient Patients H. C. Brown, Z. K. Ballas; Internal Medicine, University of Iowa, lowa City, IA.

390 Immunologic Safety Studies of Bovine-Derived Human Blood Substitute (Hemopure) M. S. Gawryl I, R. G. Hamilton2; IBiopure Corporation, Cam- bridge, MA, 2Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD.

39"1 Bnpropiou-Induced Hypersensitivity Reaction and Subarach- noid Hemorrhage: A Case Report L. E. Metzger; Salem Clinic, Salem, OR.

392 Delayed Cutaneous Reactions to Heparins J. N. Baraniuk, M. Yazicioglu, L. Kaufmann; Rheumatology, Allergy & Immunology, Georgetown University, Washington, DC.

393 Adverse Effects of Primatene Mist Used in Combination with Energy Drink Containing Ephedra Alkaloids F. M. Tai, M. H. Serwonska; Allergy, Kaiser Permanente, South San Francisco, CA.

394 Adverse Reactions to Angiotensin Receptor Antagonists in a Patient with Hereditary Angioedema (HAE) A. B. Vegh I, F. Millik2; IPuget Sound Allergy, Asthma, and Immunology, Tacoma, WA, 2Puget Sound Allergy, Asthma. and Immunology, Tacoma, WA.

395 Potential Hepatotoxicity from Complementary and Alternative Medicine (CAM)/Dietary Supplements (DS) Containing Com- frey, Chaparral, and Kava Kava H. Wong; University of British Columbia, Vancouver, BC. CANADA.

396 Pulmonary Edema After Intake of Diuretics C. Vila j, M. A. Tejedor I, I. Gonzzilez-Anglada 2, M. Fern~indez- Rivas j. A. Rosado j. M. D. Alonso I, E. Gonzaiez-Mancebo j, E.

Ortiz2; JAllergy Unit, Fundacion Hospital Alcorcon, Alcorcon, SPAIN, 21nternal Medicine, Fundacion Hospital Alcorcon, Alcor- con, SPAIN.

397 Relationship Between Methods of Polymerization and Hista- mine Releasability and Adjuvant Activity of Acrylic Resins Used in Dental Materials (DM) L. M. Du BuskO, A. A. Babakhin 2. A. I. Volozhin 3, O. D. Vino- gradova 3, A. A. Vedemikov2; qmmunology Research Institute of New England. Fitchburg, MA, 2National Research Center-Institute of Immunology, Moscow, RUSSIAN FEDERATION, 3Moscow Med- ical and Dental University, Moscow, RUSSIAN FEDERATION.

398 The Utility of Skin Testing in Suspected Clindamycin Allergy S. R. Knowles, M. J. Notman, E. J. Phillips, E. A. Weber, N. H. Shear: Drug Safety Clinic, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, CANADA.

399 Ciprofloxacin Skin Testing: A Retrospective Study M. J. Notman I, S. R. KnowlesL E. J. Phillips 3, E. A, Weber 4, N. H. ShearS; IDivision of Clinical Pharmacology, Sunnybrook and Women's College Health Sciences Center, University of Toronto, Toronto, ON, CANADA, 2Department of Pharmacy, Sunnybrook and Women's College Health Sciences Center, Toronto, ON, CANADA, 3Division of Infectious Disease, Sunnybrook and Women's College Health Sciences Center, Toronto, ON, CANA- DA, 4Drug Safety Clinic, Sunnybrook and Women's College Health Sciences Center. Toronto, ON, CANADA, 5Division of Dermatology, Sunnybrook and Women's College Health Sciences Center, Toronto, ON, CANADA.

400 Diagnosis of Allergy to Quinolones M. L. Somoza-,~lvarez I, P. Casasnovas 2, A. Jimrnez-Blanco 2, P. Poza 2, P Rico 2, C. Lozoya-lbfifiez 2. G. Canto2: JAllergy, Hospital Universitario Doce de Octubre, Madrid, SPAIN, 2H. U. Doce de Octubre, Madrid, SPAIN.

401 Expression of Different Markers in Peripheral Blood from Subjects with Immediate, Accelerated, and Delayed Cutaneous Reactions to Drugs C. Juarez I, J. A. Cornejo-Garcia I, C. Antunez i. M. J. Torres]. C. Mayorga j, J. Alvarez 2, E. Sanchez 2. M. Blanca2: 1Research Labo- ratory for Allergic Diseases, Carlos Haya Hospital, M~ilaga, SPAIN, 2Allergy Service, La Paz Hospital, Madrid, SPAIN.

402 Involvement of T Cells and the Reactive Oxygen Species in Patients with Allergic Reaction to Drugs J. A. Cornejo-GarciaL M. J, Torres I, C. Mayorga I, C. Antunez I, T. Bellon 2, S. Posadas 2, M. Blanca 2, C. Juarezr; IResearch Labo- ratory for Allergic Diseases, Carlos Haya Hospital, M~ilaga, SPAIN, 2Allergy Service, La Paz Hospital, Madrid, SPAIN.

403 Differential Expression of CD45RO Molecule in Peripheral Blood and Blister Fluid in Toxic Epidermal Necrolysis E. S~inchez I, B. Tapia I . J, Alvarez I . J. Alvarez-Ferreira 2, M. Blan- ca t, T. Bellrn]; IAllergy, University Hospital La Paz, Madrid, SPAIN, 2pathology, University Hospital La Paz, Madrid, SPAIN.

404 Early Diagnosis Key Is Vancomycin-lnduced Stevens-Johnson Syndrome and Linear IgA Bullous Dermatosis D. H. Jones. T. J. Craig, M. Todd; Penn State University, Hershey, PA.

405 CD69 for In Vitro Diagnosis of Delayed Drug Reactions M. Yazicioglu, K. Cresswell, G. Whalen, J. N. Baraniuk; George- town University, Washington, DC.

406 A Case of Local Anesthetic Hypersensitivity Cross-Reactive to Both Pharmacologic Ester and Amide Anesthetic Groups R. S. Botta, B. A. Muller; Internal Medicine, University of Iowa Healthcare, Iowa City, IA.

407 Allergy to Local Anaesthetics of the Amide Group with Toler- ance to Procaine M. Morais-AImeida, A. Gaspar, J, Rosado-Pinto; Immunoallergy Department, D. Esteffinia Hospital, Lisbon, PORTUGAL.

408 Allergy to Local Anaesthetic

$374 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

A. Spinola Santos, A. Lopes Pregal, S. Lopes da Silva, A. Vinhas de Sousa, M. Branco Ferreira, E. Pedro, A. G. Palma-Carlos; Immunoallergology, HSM, Lisbon, PORTUGAL.

409 Utility of Topic Application of NSAIDs as Diagnostic Test of Aspirin Intolerance S. H. Cimbollek 1, A. Jimenez 2, C. Lozoya 2, R. Merchan 2, C. Fer- nandez 2, R. Vives2; IAllergy, Hospital Doce de Octubre, Madrid, SPAIN, 2Hospital Doce de Octubre, Madrid, SPAIN.

410 ASA Desensitization Assisted by Monteleukast in Patients with Nasal Polyps, Asthma, and ASA Sensitivity A. S. Cheema 1, J. Mendelsohn2; 1Clinical Research Group, Mis- sissauga, ON, CANADA, 2Ent, Trillium Health Centre, Missis- sauga, ON, CANADA.

411 Valdecoxib Is a Safe Alternative Drug for NSAID-Sensitive Patients with Cutaneous Reactions M. Sdnchez-Borges, A. Capriles-Hulett, F. Caballero-Fonseca; Allergy-lmmunology, Centro Mrdico-Docente La Trinidad, Cara- cas, VENEZUELA.

412 Severe Delayed Local Reaction to Childhood Vaccinations Con- taining Adjuvants U. K. Reddy, G. Avshalomov, V. R. Bonagura; Allergy and Immunol- ogy, Long Island Jewish Medical Center, New Hyde Park, NY.

413 Relationship of Onset Time and Degree of Systemic Allergic Reactions to Measles, Mumps, and Rubella Vaccines M. Sakaguchi, K. Tanuguchi, S. Inouye; National Institute of Infectious Diseases, Tokyo, JAPAN.

414 Successful Desensitization to Paclitaxel (Taxol| in Ten Patients Using a Standardized Protocol A. Feldweg ] , K. Price 1, U. Matulonis 2, M. Castells J; J Brigham and Women's Hospital, Boston, MA, 2Dana Farher Cancer Institute, Boston, MA.

415 A Simplified Method for Rapid Intravenous Drug Desensitization R. M, Ferdman, M. Wakim, J. A. Church; Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, Los Angeles, CA.

416 Oral Desensitization to Rifampin and Ethambutol R. Lo, P. C. Avila, A. Xu, A. T. Tevrizian; Allergy and Immunolo- gy, UCSE San Francisco, CA.

417 Successful Parenteral Rapid Desensitization to Docetaxel E. I. Syrigou 1, I. Dannos 2, G. Dionellis 2, E. Psaras 2, N. Katirt- zoglou 2, O. Tsiakou 2, K. N. Syrigos2; IDepartment of Allergy, 2nd Dpt of Paediatrics, Athens Medical School, Athens, GREECE, 2Oncology Unit, Sotiria General Hospital, Athens, GREECE.

418 Desensitization to King Cobra Monoclonal Antibody H. Chantaphakul I, S. Tiyasataponc 2, K. Ruxmngtham2; qnternal Medicine, Chulalongkorn University Hospital, Bangkok, THAI- LAND, 2Chulalongkom University Hospital, Bangkok, THAILAND.

419 Readministrat ion of Oxaliplatln on a Desensitization Protocol in a Patient with Anaphylactic Reaction C. Lozoya-ib~ifiez I , A. Garcia 2, A. Feliu 2, R. C~denas 2, P. Poza 2, G. Cant02; 1Allergy, Hospital Universitario Doce de Octubre, Madrid, SPAIN, 2Hospital Universitario Doce de Octubre, Madrid, SPAIN.

420 Validation of Pharmacovigilance Algorithms in Drug Hyper- sensitivity Reactions S. Benahmed I, D. Messaad 2, D. Hillaire-Buys 3, P. Godard 4, J. Bousquet 4, P. Demoly4; ~Maladies Respiratoires, University Hos- pital of Montpellier, Montpellier, FRANCE, 2University Hospital of Montpellier, Montpellier, FRANCE, 3pharmacovigilance, Uni- versity Hospital of Montpellier, Montpellier, FRANCE, 4Maladies Respiratoires, Montpellier, FRANCE.

Latex Allergy 421 Latex Allergy

Pos te r Session 3509

Sunday, March 9 11:15 AM to 12:I5 PM

M. Castro, N. Mathur, H. J. Moallem, R. Joks, A. Josephson; Departments of Pediatrics and Medicine, Division of Allergy & Immunology, SUNY Downstate Medical Center, Brooklyn, NY.

422 Allergy Prevalence Increase in Latex-Sensitized Spina Bifida Patients A. M. Romeira t, G. PireU, A. GasparJ, N. Godinho l, V. Loureiro 1, V. Matos I, E. Calado 2, M. Morais-Almeida ~, J. Rosado-Pintoi; qmmunoallergy Department, Dona Estef~nia Hospital, Lisbon, PORTUGAL, 2Neurology Department, Dona Estef~nia Hospital, Lisbon, PORTUGAL.

423 Recombinant Allergen-Based ELISA for the Simultaneous Detection of IgE to Clinically Relevant Latex Allergens T. Palosuo j, T. Karkkainen 2, K. Frisk 2, K. Turjanmaa 3, H. Ale- nius 4, M. Kulomaa 5, N. Kalkkinen 6, T. Reunala3; JNational Public Health Institute, Helsinki, FINLAND, 2FIT Biotech, Tampere, FINLAND, 3Tampere University Hospital, Tampere, FINLAND, 4Finnish Institute of Occupational Health, Helsinki, FINLAND, 5University of Jyvaskyl~i, Jyv~iskyl~i, FINLAND, 6University of Helsinki, Helsinki, FINLAND.

424 Latex-Specific IgE Assay Sensitivity Enhanced Using Hey b 5 Enriched Latex Allergosorhent R. G. Hamilton I, C. E. RossP, H. Y. Yeang 2, D. I. Bernstein 3, R. Biagini4; qohns Hopkins University School of Medicine, Balti- more, MD, 2Rubber Research Institute of Malaysia, Kuala Lumpur, MALAYSIA, 3University of Cincinnati, Cincinnati, OH, 4NIOSH, Cincinnati, OH.

425 Specific Immunotherapy with a Standardized Latex Extract in Allergic Workers: A Double-Blind, Placebo-Controlled Study J. Sastre j, M. Fermindez-Nieto I , P. Rico 2, S. Martin 2, D. Barber 2, J, Cuesta 1, M. De las Heras 1, S. Quircet; IAllergy, Fundacion Jimenez Diaz, Madrid, SPAIN, 2ALK-Abello, Madrid, SPAIN.

426 A Four-Year Prospective Study to Evaluate the Efficacy of Glove Interventions in Preventing Natural Latex Sensitization in Healthcare Workers at Two Hospitals K. J. Kelly I, M. Klancnik 2, V. Kurup 2, C. Barrios-Janko 2, J. N. Pink 2, E. L. Petsonk3; IAllergy/Immunology, Medical College of Wisconsin, Milwaukee, WI, 2Medical College of Wisconsin, Mil- waukee, WI, 3NIOSH/CDC, Morgantown, WV.

427 Iutragastric Sensitization of Latex Allergens Results in Sys- temic Allergic Responses in a Murine Model C. S. Barrios t, V. P. Kurup l, B. Banerjee ] , J. D. Henderson, Jr. 2, I. A. Vlasova I, J. N. Fink I, K. I. Ke]lyl: IPediatrics, Medical College of Wisconsin, Milwaukee, WI, 2Surgery, Medical College of Wis- consin, Milwaukee, WI.



Application of Quality-of Life Measures 428 Psychometric Validation of a Japanese Translation of the

RQLQ and WPAI-AS B. Crawford I, M. Okuda2; JMapi Values, Boston, MA, 2Nippon Medical School, Tokyo, JAPAN.

429 Pediatric Asthma Quality of Life Questionnaire: Validation in Children from Thailand O. Poachanukoon I, N. Visitsunthorn 2, P. Vichyanond 2, W. Lear- mankuP; IPediatrics, Faculty of Medicine, Siriraj Hospital, Bangkok, THAILAND, 2pediatrics, Siriraj Hospital, Bangkok, THAILAND, 3pharmacy, Silpakorn University, Nakompathom, THAILAND.

430 Effect of 1-Year Immunotherapy on Asthma Quality of Life A. Roger, M. Baltasar, E. Martf; Allergy Unit. H.U. Germans Trias i Pujol., Badalona, SPAIN.

431 Asthma Education and Its Effect on Quality of Life C. J. Collura-Barke I , B. Speller-Brown 2, L. J. Smith l, M. R. Ncl-


son l, H. J. Schmidt2; IAllergy/Immunology, Walter Reed Army Medical Center, Washington, DC, 2pediatrics, Walter Reed Army Medical Center, Washington, DC.

432 Impact of Allergic Rhinitis on Simulated Real World Performance U. Satish, S. Streufert, S. Vandervort; Psychiatry, SUNY Upstate Medical University, Syracuse, NY.

433 Improvement of Life Quality in HIV(+) Zoster Patients by Acupuncture K. Cui; Department of Traditional Chinese Medicine, 1st People Hospital of Zhengzhou, Zhengzhou, CHINA.

Poster Session 3511

Sunday, March 9 11:15 A M to 12:15 P M

Mechanisms of Allerg4c Pathogenesis in Human Atopic Diseases 434 Persistent Eosinophilia and Skin Lesions as Presenting Symp-

toms of Ulcerative Colitis H. J. Moday l, D. Berkowitz 2, D. L. Rosenstreichl; IDivision of Allergy and Immunology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 2Dept of Gas- troenterology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.

435 Serum Mast Cell Tryptase Levels (STL) Are Elevated in Hemodialysis Patients and Correlate with the Intensity of Pru- ritus S. Breit I , P. SchOpf I, M. Dugas 2, H. Schiffi 3, F. Rueff J, B. Przy- bill#; IKlinik und Poliklinik for Dermatologie und Allergologie, Mfinchen. GERMANY, 2Institut fur Medizinische Informa- tionsverarbeitung, Biometrie und Epidemiologie, MOnchen, GER- MANY, 3Kuratorium ftir Dialyse, Mtinchen, GERMANY.

436 Phospholipase A 2- and Hyaluronidase-Specific IgG 4 Defines Allergenicity and/or Hyperimmunity to Bee Venom E. M. Varga 1, C. Manhart 2, A. Pfleger I, M. Zach 1, Z. Markovic- Ho 3, K. Blaser 2, C. Akdis2; lRespiratory and Allergic Disease Division, University of Graz, Dep. of Pediatrics, Graz, AUSTRIA, 2Swiss Institute of Allergy and Asthma Research (SIAF), Davos, SWITZERLAND, 3Biocentrum, Basel, SWITZERLAND.

437 Interleukin-2 Primes Eosinophil Degranulation in Hypere- osinophilia and Wells' Syndrome H. Simon I , E Levi-Schaffer2; I Pharmacology, University of Bern, Bern, SWITZERLAND, 2Pharmacology, The Hebrew University, Jerusalem, ISRAEL.

438 IgE Serum Levels After Treatment in Children with Moderate Asthma J. Jerzynska 1 , I. Stelmach I , W. SteImach 2, P. Majak I , T. Grzelews- ki t, P. Kuna3; tDepartment of Paediatrics and Allergy, M. Curie Hospital, Zgierz, POLAND, 2Regional Health Authority, Lodz, POLAND, 3Department of Allergy and Pneumonology, Medical University, Lodz, POLAND.

439 Seasonal Nephrotic Syndrome Associated with Seasonal Aller- gic Rhinitis S. D. Betschel 1, P. Vadas2; IDepartment of Allergy and Clinical Immunology, University of Toronto, Toronto, ON, CANADA, 2Division of Allergy and Clinical Immunology, St. Michael's Hos- pital, Toronto, ON, CANADA.

440 Temporal Variation in Total Serum IgE Levels in a Population- Based Sample from Tangier Island, VA R. A. Mathias l, M. Stockton 2, A, E Wilson I, K. C. Barnes2; 1NHGRI/NIH, Baltimore, MD, 2Johns Hopkins University, Balti- more, MD.

441 High Circulating Soluble CDI4 (sCD14) Levels Are Not Asso- ciated with Asthma or Atopy in an Afro-Caribbean Populatlon from Barbados M. L. Stockton; Clinical Immunology, Johns Hopkins University, Baltimore, MD.

442 Pertussis-Vaccine Antigen Induced Cytokine Responses from Pertussis-Vaccinated Children During Their First Year of Life A. I. Lahdenperii, M. C. Jenmalm, L. Nilsson; Department of Molecular and Clinical Medicine, Division of Paediatrics, Link6ping, SWEDEN.

443 Signaling Defects in Basophils in Chronic Urticaria S. S. Saini, K. Vasagar, E Haung, S. P. Gibbons, Jr., B. M. Vonakis; Clinical Immunology, Johns Hopkins University, Baltimore, MD.

444 Reduction of Serum IL-10 Levels in Atopic Infants with Respi- ratory Syncytial Virus Bronchiolitis L. Dong j, X. F. Chen I, C. C. Li2; IDept of Pediatrics, Yuying Chil- dren's Hospital, Wenzhou Medical College, Wenzhou, Zhejiang Province, CHINA, 2Dept of Pediatrics, Yuying Children's Hospital, Wenzhou Medical College, Wenzhou, Zhejiang Province, CHINA.

445 Eosinophil Degranulation During Pregnancy and After Deliv- ery with Caesarian Section K. Matsumoto I, T. Ogasawara I, M. lid#, A. Akasawa 2, H. Saitol; JAllergy and Immunology, National Research Institute for Child Health and Development, Tokyo, JAPAN, 2Interdisciplinary Medicine, National Institute for Child Health and Development, Tokyo, JAPAN.

446 IL-10 Serum Levels in Children with Moderate Atopic Asthma I. Stelmach j , J. Jerzynska ~ , W. Stelmach 2, P. Majak ~ , T. Grzelews- ki I, P. Kuna3; IDepartment of Paediatrics and Allergy, M. Curie Hospital, Zgierz, POLAND, 2Regional Health Authority, Lodz, POLAND, 3Department of Allergy and Pneumonology, Medical University, Lodz, POLAND.

447 Analysis of T-Cell Responses to Cat in Patients with Atopic Dermatitis R. M. Carneiro I, A. J. Reefer I, T. A. E. Platts-Mills I, B. B. WiI- son 2, N. J. Custis 1, J. A. Woodfolkl; IAsthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA, 2Department of Dermatology, University of Virginia, Charlottesville, VA.

448 Th2 Skewing of the Immunologic Development in Infants with Atopic Dermatitis and Wheezing W. A. Neaville l, C. Tisler 2, D. DaSilva 2, K. Anklum 2, K. Roberg 2, K. Carlson-Dakes 2, B. Anderson 2, A. Bhattacharya 2, R. Gangnon 2, J. E. Gem 2, R. E Lemanske, Jr.2; IAIlergy/Immunology, Universi- ty of Wisconsin-Madison, Madison, WI, 2University of Wiscon- sin-Madison, Madison, WI.

449 The Relationship of Asthma Severity to Pulmonary Eosinophilia N. Jarjour, J. B. Sedgwick, L. Liu, B. Kelly, W. W. Busse; Medi- cine, University of Wisconsin, Madison, WI.

450 Histamine-Dependent Upregulation of Eotaxin by Endothelial Cells In Vitro and in the Skin of Atopic Allergic Volunteers A. N. Menzies-Gow, S. Ying, A. B. Kay; Allergy and Clinical Immunology, NHLI Division, Imperial College London, London, UNITED KINGDOM.

451 Low IL-10 Production by Der p i-Specific T Cells in Severe Atopic Dermatitis S. L. Seneviratne l, L. Jones I, A. Black l, A. King f, S. Powell 2, A. J. McMichael j, G. S. Oggl; IMRC Human Immunology Unit, Institute of Molecular Medicine, Oxford, UNITED KINGDOM, 2Department of Dermatology, Churchill Hospital, Oxford, UNIT- ED KINGDOM.

452 Activation of Human Skin-Derived Mast Cells by Sera from Patients with Recurrent Urticaria W. Zhao, C. W. Greene, Jr., C. A. Oskeritzian, L. B. Schwartz; Rheumatology, Allergy and Immunology, Virginia Commonwealth University, Richmond, VA.

453 Chronic Urticaria and Infection by Helicohacter Pylori (H.P.) M. Giubi; Hospital de Clinicas, Asuncion, PARAGUAY.

454 Allergy Diagnosis: Value of CD63 and CD203c Basophil Acti- vation Markers , LTC4 Release and Quantitative Real Time PCR for Th2 Cytokines A. Ocmant I , L. Schandene i, p. Stordeur I ' y. Peignois j ' A. Michils 2, M. Goldmanl; IDpt of Immunology, H6pital Erasme, Universit6


Libre de Bruxelles, Brussels, BELGIUM, 2Chest Dpt, H6pital Erasme, Universit6 Libre de Bruxelles, Brussels, BELGIUM.

455 Decreased Cytokine Response Profiles as a Predictor of Aller- gic Sensitization C. J. Tisler, Z. Li, D. DaSilva, K. Anklum, K. Roberg, K. Carlson- Dakes, B. Anderson, R. Gangnon, J, E. Gem, R. E Lemanske, Jr.; University of Wisconsin Medical School, Madison, WI.

456 Con-A Binding Fraction Isolated from Blomia Tropicalis (CBF-Bt) Recognized by Specific IgE Antibodies in Atopic Patients E. A. Taketomi; Immunology, Federal University of Uberlandia, Uberlandia, BRAZIL.

457 Objective Evaluation of Skin Test Reactions Using Digital Pho- tography R. V. Santos I , H. C. Lima 2, N. A. Rosario~; 1University of Parana, Allergy Division, Curitiba, BRAZIL, 2University of Santa Catari- na, Immunology Division, Florianopolis, BRAZIL.

458 Correlation Between Cap Assay and Skin Prick Test in Allergic Patients Y. Ahn; Pediatrics, Samsung Medical Center, Seoul, REPUBLIC OF KOREA.

459 RANTES and Eotaxin-I in the Gut of Children with Eosinophilic Gastroenteropathy S. J. McGeady 1, A. Lateef 2, C. Barone 3, C. J. Justinich 4, W. AI- Herz2; I Allergy and Immunology, A. I. duPont Hospital for Children and Thomas Jefferson University, Wilmington, DE, CA. I. duPont Hospital tbr Children and Thomas Jefferson University, Wilmington, DE, 3A. I. duPont Hospital for Children, Wilmington, DE, 4Gas- troenterology, A. I. duPont Hospital for Children, Wilmington, DE.

460 Expression of Keratinocyte Growth Factor (KGF) is Upregu- iated in Nasal Polyp Disease K. R. Girgis I, M. Danley 2, N. Y. Olson 3, O, W. Tawfik 2, D. J. Stechschulter; qnternal Medicine, Kansas University Medical Center, Kansas City, KS, 2Department of Pathology and Laborato- ry Medicine, Kansas University Medical Center, Kansas City, KS, 3Department of Pediatrics, Kansas University Medical Center, Kansas City, KS.

461 Interest and Limits of Basotest| in the Detection of Allergic Diseases B. Arnoux I, M. Rongier 1, B. LebeP, J. Bousquet 1,2, P. Demolyl.2; IU454, INSERM, Montpellier, FRANCE, 2Service d' Allergologie, CHU Montpellier, Montpellier, FRANCE.

Poster Session 3512


Mast Cells and Basophils 462 The TNF-a Converting Enzyme (TACE/ADAM 17) is

Expressed on Human Mast Cells and Augmented Upon Het- erotypic Adhesion with T Cells P. Salamon I, D. Baram 2, Y. A. Mekori3; JMeir Hospital, Kfar- Saba, ISRAEL, 2Meir Hospital, Kfar-Saba, ISRAEL, 3Medicine B, Meir Hospital, Kfar-Saba, ISRAEL.

463 Rodent Alpha-chymases are Eiastase-like Proteases Y. Kunori; Teijin Institute for Bio-medical Research, Teijin Ltd, Hino, JAPAN.

464 Secretion of Basogranulin from Human Basophils in Response to IgE-Dependent and Non-IgE-Dependent Stimuli A. Mochizuki, A. R. McEuen, M. G. Bnckley, A. F. Walls; Rcmb, University of Southampton, Southampton, UNITED KINGDOM.

465 Localization of Plasma Membrane Phospholipid (PL) Scram- bling in Relationship to PL Scramblase 1 in Neutrophils, Jurkat and Rat Basophil Leukemic Cells D. L. Bratton, C. Goddard, J. Kailey, S, C. Frasch, P. Hensou; Pedi- atrics, National Jewish Medical and Research Center, Denver, CO.

466 Sustained Phosphorylation of ERK and Akt in Basophils from People with the Hyper-releasable Phenotype B. M. Vonakis, J. Langdon, R. Sora, S. Gibbons, Jr., S. M. Mac- Donald; Medicine, Johns Hopkins University, Baltimore, MD.

467 Activation of Human Colonic Mast Cells Through Proteinase Activated Receptor-2 (PAR-2) S. He I, Y. He 2, H. Xie I, A. E Wails2; JUniversity of Southamp- ton/Shantou University Medical College, Southampton/Shantou, CHINA, 2University of Southampton, Southampton, UNITED KINGDOM.

468 Stem Cell Factor Induces Cytokine Expression in Human Intestinal Mast Cells Pre-Cultured with IL-4 A. Lorentz, L. E. Sander, G. Sellge, M. P. Manns, S. C. Bischoff; Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, GERMANY.

469 Phenotypic Characterization of Human Cord Blood Derived Mast Cells in Respect to Chemokines and Chemokine Receptor Genes C. DahF, H. Kvistgaard Nielsen 2, S. Junker 3, P. Schiotz4; EPedi- atric Department, A Researchlab, Aarhus, DENMARK, 2Pediatric Department, A Research, Aarhus, DENMARK, 3Department of Human Genetics, Human Genetics, Aarhus, DENMARK, 4Pedi- attic Department, A Research, Aarhus, DENMARK.

470 Evaluation of Functional Differences in Peanut-specific lgE Using a Flow Cytometric Basophii Activation Assay Following in vitro Passive Sensitization of Normal Human Basophils W. G. Shreffier, K. Jarvinen, K. Beyer, H. A. Sampson; Jaffe Food Allergy Institute, Division of Pediatric Allergy & Immunology, Mount Sinai School of Medicine, New York, NY.

471 TGF-[~ 1 Selectively Supports Prostaglandin D 2 Production in Activated Human Mast Cells T. Gebhardt, E Detmer, A. Lorentz, G. Sellge, M. P. Manns, S. C. Bischoff; Department of Gastroenterology, Medical School Han- nover, Hannover, GERMANY.

472 Interferon-gamma Reduces Survival of Human Intestinal Mast Cells and Induces MHC Class I1 Expression G. Sellge, A. Lorentz. J. Hoppe, T. Gebhardt, M. P. Manns, S. C. Bischoff; Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, GER- MANY.

473 Identification of Endothelin B Receptors on Human Mast Cells J. C. Anthes, S. Eckel, C. Richard, S. Greenfeder, R. W. Egan, M. Billah; Allergy, Schering-Plough Research Institute, Kenilworth, NL

474 CXCR2 is a Required Chemokine Receptor for Mast Cell Progenitor Homing to the Murine Intestine J. P. Abonia, M. E Gurish, K. E Austen, D. S. Friend, J. A. Boyce; Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA.

47'5 Regulation and Molecular Function of Peroxisome Proliferator Activated Receptors in Human Mast Cells C. Sarubhi, S. Lee, S. Clark, S. Whaley. K. Hall, K. Krishnan, K. Cantor, G. Krishnaswamy; Internal Medicine, James H, Quillen College of Medicine and East Tennessee State University, Johnson City, TN.

476 Expression of Protease Activated Receptors on Human Basophils and KU812 Cells J. R. Purkiss, A. Mochizuki, A. S. Holmes, A. F. Wails; Rcmb, University of Southampton, Southampton, UNITED KINGDOM.

477 Down-regulation of Th2 Cytokine Expression by Glucocorti- colds in Cultivated Human Lung Mast Cells J. G. Mohanty, J. M. Abboud, E. S. Schulman; Pulmonary and Critical Care Medicine, Drexel University College of Medicine, Philadelphia, PA.


Asthma Mechanisms 2:15 478


Sunday, March 9 2:15 PM to 4:15 PM

Induction of Resistin-Like Molecule Beta (RELM-beta) by Respiratory Allergen, IL-4, IL-13, and STAT6 in Experimental Asthma C. W. DeBrosse, N. Zimmermann, N. E. King, S. M. Pope, P. C. Fulkerson, A. Mishra, M. E. Rothenberg; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

2:30 479

2:45 480

3:00 481

3:15 482

3:30 483

3:45 484

4:00 485

EosinophiI-Derived IL-I[], TGF-[3 and bFGF Induce Lung Fibroblast Secretion of the Pro-Fibrogenic Cytokine IL-6: A Potential Mechanism for Subepithelial Fibrosis in Asthma I. Gomes 1, B. M. EspendshadO, S. K. Mathur j, J. Varga 2, S. J. Ackermant; ~Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, Chicago, IL, 2Department of Medicine, University of Illinois at Chicago, Chicago, IL.

Interactions between the Frequency of Viral Infections and IFN-'~ Production in the First Year of Life D. F. DaSilva ], K. A. Roberg j, K. T. Carlson-Dakes 1, C. J. Tisler i, K. Shen j, P. A. Shult 2, C. J. Kirk 2, R. E. Gangnon 3, J. E. Gern i, R. E Lemanske, It.I; i Department of Pediatrics, University of Wis- consin-Madison, Madison, WI, 2Wisconsin State Laboratory of Hygiene, University of Wisconsin-Madison, Madison, Wl, 3Bio- statistics and Medical Informatics, University of Wisconsin-Madi- son, Madison, Wl.

Chemokine Receptor Expression on Lung-derived T Cells of Mild Asthmatics after Segmental Allergen Challenge T. Kallinich I, S. Schmidt 2, E. Hamelmann j, C. Virchow 2, W. Luttmann 3, R. Kroczek4; ]Department of Pediatrics, Division of Pulmonology and Immunology, University Hospital Charitr, Berlin, GERMANY, 2Department of Internal Medicine, Division of Pulmonology, University of Rostock, Rostock, GERMANY, 3Department of Internal Medicine, Division of Pulmonology, Uni- versity of Freiburg, Freiburg, GERMANY, 4Molecular Immunolo- gy, Robert Koch-lnstitut, Berlin, GERMANY.

Diminished Dendritic Cell (DC) IL-10 Production in Children with Allergic Rhinitis (AR) and/or Asthma R. L. Schreiber, D. A. Gentile, J. Howe-Adams, J. Trecki, A. Patel, P. Fireman, D. P. Skoner; Department of Pediatrics, Chil- dren's Hospital of Pittsburgh, Pittsburgh, PA.

Bone Marrow Derived Inflammatory Cells Traffic to Airways in Allergic Airway Inflammation A, H. Johansson 1, S. Sergejeva 1, J. J. Lee 2, J. Lotvall]; ~Dept. of Respiratory Medicine and Allergology, Inst. of Internal Medicine, Gothenburg University, SWEDEN, 2Division of Pulmonary Medi- cine, Mayo Clinic, Scottsdale, AZ.

Endotoxin is a Marker for Bacterial DNA in Dust A. M. Schiltz, S. R. Roy, Y. Shen, A. H. Liu; Pediatric Allergy & Clinical Immunology, National Jewish Medical & Research Cen- ter, Denver, CO.

Polymorphisms of the Cyclooxygenase-1 and 5-Lipoxygenase Activating Protein Enzyme Genes in Patients with Aspirin Exacerbated Respiratory Disease B. L. Zuraw I, J. Namazy I, D. D. StevensonZ; 1Molecular &

Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 2Division of Allergy, Asthma, and Clinical Immunology, Scripps Clinic Medical Group, La Jolla, CA.



Primary Immunodeficiency 2:15 486 Interleukin-7 Receptor a Chain Mutations in 13 Patients with

Severe Combined Immunodeficiency J. L. Roberts, S. M. Brown, R. H. Buckley; Pediatrics, Duke Uni- versity Medical Center, Durham, NC.

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Mechanism of Recruitment of WASP-WIP Complex to the Immunological Synapse and of WASP Activation Following TCR Ligation Y, Sasahara, R. Rachid, M. J. Byrne, M, A. de la Fuente, N. Ramesh, R. S. Geha; Division of Immunology, Children's Hospi- tal, Harvard Medical School, Boston, MA.

Identification of Dysregulated Cytokine Networks in Human Severe Combined Immunodeficiency Using Antibody-Based Microarrays for Protein Profiling D. D. PateP ,2 V. Tchernev 2, S. Lezhnin 2, E. Satyaraj ~, R. H. Buck- Icy ], S. E Kingsmore2; ~Duke University Medical Center, Durham, NC, 2Molecular Staging lnc, New Haven, CT.

Collective Experience of the DHR Assay in CGD K. R. Hirsch 1, O. Jirapongsananurk ~, T. A. Fleisher l, H. L. Malech 2, D, B. Kuhns 3, M. R. Brown I, S. M. Holland 2, G. UzelJ; I Department of Laboratory Medicine, Warren G. Magnuson Clini- cal Center, National Institutes of Health, Bethesda, MD, 2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 3National Cancer Institute, National Insti- tutes of Health, Frederick, MD.

The Spectrum of Clinical Phenotype and Immunodeficiency due to NFkB Essential Modifier (NEMO) Mutation J. S. Orange l, S. R. Brodeur ], A. Jain 2, Z. K. Ballas 3, L. C. Schneider l, E A. Bonilla 1, R. S. GehaJ; J Department of Immunol- ogy, Children's Hospital, Boston, MA, 2National Institutes of Health, Bethesda, MD, 3University of Iowa, Iowa City, IA.

Lower In Vitro Lymphoproliferative Responses to Tetanus Tox- oid at 1 Year in Infants Who Are Atopic at 3 Years F. I. Smillie I, E. C. McKie 1, A. J. Elderfield I, R. B. Gore i, P. Kissen ], G. Tavernier 1, E Y. Patel j, P. D. Arkwright 2, I. Hutchin- son 3, A. Custovic I A. Woodcock] ; iNorth West Lung Centre, Man- chester, UNITED KINGDOM, 2Department of Child Health, Uni- versity of Manchester, Manchester, UNITED KINGDOM, 3Department of Immunology, University of Manchester, Manches- ter, UNITED KINGDOM.

A Family Study of Mannose~ Lectin Deficiency Pre- sented as Severe Recurrent Infections Evidenced by Genetic and Immunological Analysis D. P. Martin, R. A. Good, S. Haraguchi, L. Johnson, N. K. Day; Pediatrics, All Children's Hospital, St. Petersburg, FL.

CD5 Primary Immunodeficiency: Bacteriophage Characteri- zation R. W. E, Hostoffer, J r ) , H. Ochs 2, N. Wasserbauer3; 1Case West- ern Reserve University, Cleveland, OH, 2Immunology, University

$378 Abst rac ts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

of Washington, Seattle, WA, 3Chicago College of Osteopathic Medicine, Chicago, IL.


Sunday, M a r c h 9 2 :15 P M to 4 :15 P M

Environmental Irritants at Home and in the Workplace 2.'15 494 Influence of Age, Gender, and Atopy on Nasal I r r i tant Sensi-

tivity D. Shusterman 1, M. Murphy 2, J. BalmesJ; IMedicine, University of California, San Francisco, San Francisco, CA, 2Pediatrics, Uni- versity of California, San Francisco, San Francisco, CA.

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Exposure to Environmental Tobacco Smoke (ETS) Assessed by Personal Monitors Decreases Pulmonary Function in Children with Asthma N. Rabinovitch; Pediatrics, National Jewish Medical and Research Center, Denver, CO.

Risk Factors for Annual FEV1 Decrease in Textile Industry Workers J. A, Ferreira, E. Castro, J. Torres Costa, M. Vaz; Allergy Unit, Hospital S. Jo~o, Porto, PORTUGAL.

Occupational Asthma (OA) and IgE Sensitization to Serra- tiopeptidase (SP) in Workers Exposed in a Pharmaceutical Company Y. Lee 1 , Y. Suh 2, M. Kim 3, D. Nahm 3, H. Park 3, J. Choi 3, H. Yoon4; llnternal Medicine, Soonchunhyang University, Seoul, REPUB- LIC OF KOREA, 2Internal Medicine, Ajou University School of Medicine, Suwon, REPUBLIC OF KOREA, 3Ajou University School of Medicine, Suwon, REPUBLIC OF KOREA, 4Hanyang University, Seoul, REPUBLIC OF KOREA.

High Prevalence of Sensitization and Symptoms of Occupa- tional Asthma (OA) in Snow-Crab Processing Workers of New- foundland and Labrador A. Cart ier l, S. B. Lehrer 2, L. Horth-Susin 3, M. Jong 4, M. Swan- son 5, B. Neis6; IH6pital du Sacr6-Coeur de Montr6al, Montreal, PQ, CANADA, 2Tulane University, New Orleans, LA, 3Valley Regional Hospital, Kentville, NS, CANADA, 4Health Labrador Corporation, Goose Bay, LB, CANADA, 5Mayo Clinic, Rochester, MN, 6Memorial University, St. John's, NF, CANADA.

Latex Hypersensitivity in VA Healthcare Workers A. M. Chiu l, C. R. Zeiss 2, A. Gomaa 3, D. N. Weissman 4, E M. Murphy 5, M. Hodgson 5, D. Foster 6, S. Dejativongse 7, K. Colella 7, K. Kestenberg 4, V. P. Kurup 8, R. K. Bush 9, J. N. Finkl~ 1Aller- gy/Immunology, Medical College of Wisconsin, Milwaukee, WI, 2Allergy/Immunology, Feinberg School of Medicine Northwestern University/Department Veterans Affairs, Chicago, IL, 3CDC/NIOSH, Cincinnati, OH, 4CDCfNIOSH, Morgantown, WV, 5Veterans Health Administration, Washington, DC, 6Department Veterans Affairs, Milwaukee, WI, 7Department Veterans Affairs, Chicago, IL, SMedical College of Wisconsin, Milwaukee, WI, 9University of Wisconsin/Department Veterans Affairs, Madison, WI, lOMedical College of Wisconsin/Department Veterans Affairs, Milwaukee, WI.

Occupational Asthma Caused by a Primary Amine Contained in Metal Cutting Fluid E. Comp~s I , M. Ferndndez-Nieto I , S. Quirce I , M. Etxenagusia 2, J. Lobo 2, E. Ferndndez 2, M. Audicana 2. J. Sastrel; IFundaci6n

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Jim6nez Dfaz, Madrid, SPAIN, 2Hospital Santiago Ap6stol, Vito- ria, SPAIN.

lnterlaboratory Agreement of Toluene Diisocyanate (TDI)-Spe- cific Serum Antibody Results Are Strongly Influenced by Anti- gen Characteristics Z. L. Lummus l, H. S. Park 2, W. E. Brown 3, A. T. Jolly 4, R. E. Biagini 5, M. A. Wanner I, D. M. Lewis 6, A. L. Burkert 3, H. Daftar- ian 5, D. 1. Berusteinl; IUniversity of Cincinnati, Cincinnati, OH, 2Ajou University, Suwon, REPUBLIC OF KOREA, 3Carnegie Mellon University, Pittsburgh, PA, 4International Isocyanate Insti- tute, West Chester, PA, 5NIOSH, Cincinnati, OH, 6NIOSH, Mor- gantown, WV.


Sunday, M a r c h 9 2 :15 P M to 4 :15 P M

New Concepts in Peanut Allergy 2:15 502 The Natural Progression of Peanut Allergy

D, M. Fleischer, M. K. Conover-Walker, R. A. Wood; Department of Allergy and Immunology, Johns Hopkins University, Baltimore, MD.

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Quality of Life in Children with Peanut Allergy No J. Avery 1, R. M. King 2, S. Knight 3, J. O. Hourihanel; qnfection, Inflammation and Repair Division, University of Southamp- ton, Southampton, UNITED KINGDOM, 2Wellcome Trust Clini- cal Research Facility, Southampton University Hospital NHS Trust, Southampton, UNITED KINGDOM, 3Department of Psy- chology, Southampton University Hospital NHS Trust, Southamp- ton, UNITED KINGDOM.

The Prevalence of Peanut Allergy in Quebec Schoolchildren, Ages 5-9 R. S. Kagan I, E. Turnbull 2, L. Joseph 3, Y. St. Pierre 4, C. Dufresne 5, K. Gray-Donald 6, A. E. Clarke7; IPediatrics, Divisions of Allergy/Clinical Immunology and Rheumatology, McGill Uni- versity Health Centre, Montreal, PQ, CANADA, 2McGill Univer- sity Health Centre, Montreal, PQ, CANADA, 3Epidemiology and Biostatistics, McGill University Health Centre, Montreal, PQ, CANADA, 4Epidemiology and Biostatistics, McGill University. Montreal, PQ, CANADA, 5Association des Allergies Alimentaires du Quebec, Montreal, PQ, CANADA, 6Dietetics, McGill Universi- ty, Montreal, PQ, CANADA, 7Medicine, Divisions of Allergy/ Clinical Immunology and Clinical Epidemiology, McGill Univer- sity Health Centre, Montreal, PQ, CANADA.

Peanut Allergen (Ara h 1) Detection in Foods Containing Chocolate R. Vinton, M. D. Chapman, A. Pomes; INDOOR Biotechnologies, Inc, Charlottesville, VA.

Relevance of Ara hl, Ara h2, and Ara h3 in Peanut Allergic Patients, as Determined by IgE-Western-BIotting, Basophil Histamine Release, and Intracutaneous Testing: Ara h2 is the Most Important Peanut Allergen E. F. Knol l, M. Wensing I, R. Vlooswijk 2, M. Ertmann I, A. C. Knulst 1, S. J. Koppelman2; IDermatology/Allergology, University Medical Center Utrecht, Utrecht, NETHERLANDS, 2TNO Nutri- tion and Food Research Institute, Zeist, NETHERLANDS.

A Murine Model for the Evaluation of the Allergenic Potency of Foods

J ALLERGY CLIN IMMUNOL A b s t r a c t s S379 VOLUME 111, NUMBER 2

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G, Reese, S. Kaul, S. Randow, A. Hoffmann, S. Vieths; Allergolo gy, Paul-Ehrlich-lnstitut, Langen, GERMANY.

Persistent Effect of Immunotherapy with "Engineered" Recombinant Peanut Protein and a Bacterial Adjuvant on Peanut Hypersensitivity X. Li I, K. D. Srivastava I , A. Grishin I , J. S. Stanley 2, A. W. Burks 2, H. A. Sampsont; ~Pediatrics, Mount Sinai School of Medicine, New York, NY, 2University of Arkansas Medical School. Little Rock, AR.

Can Processing Be Used to Reduce Allergenic Properties of Peanuts? S. J. Maleki 1, O. Viquez e, T. Jacks 3, H. Dodo 4, E. T. ChampagneS; IAllergy, USDA-ARS, New Orleans, LA, 2University of Alabama A&M, Normal, AL, 3USDA-ARS, New Orleans, LA, 4University of Alabama A&M, Normal, AL, 5USDA, New Orleans, LA.



Care of Underserved Populations 2:15 510 Successful School-Based Intervention for Inner City Children

with Persistent Asthma: A Case-Controlled Study M. E. Anderson 1 , M. R. Freas 2, A. S. Wallace t , A. H. Liu2; ICom munity Health, Pediatrics, Denver Health, Denver, CO, 2National Jewish, University of Colorado HSC, Denver, CO.

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Evaluation of Atopy in the Asthmatic Population of St. Vincent and the Grenadines H. Bacchus i, C. D. Schwindt2; IMinistry of Health and the Environ- ment, St. Vincent, SAINT VINCENT AND THE GRENADINES, 2pediatrics, University of Maryland, Baltimore, MD.

Utility of FEV1% as a Screening Tool for Asthma M. L. Dyer 1, M. Li I, T. Kimia I, L. Clement 1, K. Kwong J, N. Maalouf t, J. Hanley-Lopez I, K. Feliciano i, T. Morphew l, F. Lison 2, C. Jonesl; ILos Angeles County + University of Southern California Medical Center, Los Angeles, CA, 2Southern California Chapter of the Asthma and Allergy Foundation of America, Los Angeles, CA.

Children with Asthma at Risk in America (CARA): A Survey of Parents' Concerns about Asthma J. Golding j, S. Wade2; LAstraZeneca, LP, Wilmington, DE, 2Har- ris Interactive, Claremont, CA.

Prevalence and Causes of Medication Non-compliance in Dis- advantaged Elderly Patients with Reversible Obstructive Air- ways Disease C. A. Saltoun, P Yarnold, L. C. Grammer; Northwestern Universi- ty Medical School, Chicago, IL.

Primary Care Provider (PCP) Adherence to NAEPP Guide- lines Among High-Risk Inner-City Children With Asthma K. A. Riekert I , K. Huss 2, A. M Butz 3, P. Eggleston 3, M. Winkel stein 2, C. S. Randl; IMedicine, Johns Hopkins University, Balti- more, MD, 2Nursing, Johns Hopkins University, Baltimore, MD, 3pediatrics, Johns Hopkins University, Baltimore. MD.

Risk Factors for Asthma among Head Start Children: Evalua- tion of Physical Activity and Allergy V. L. FirrincielP, B. Geldmaker 2, N. Custis 1, R. Ehrensberger 2, E. Erwin t. D. Riposo t, C. Shufflebarger 2, L. Ferguson 2, T. Platts

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Millsi; JAllergy and Immunology, University of Virginia, Char- lottesville, VA, 2CARMA, Richmond, VA.

Prevalence of Recurrent Respiratory Episodes in Preschool Children--PREPAC H. Bisgaard; Pediatrics, Copenhagen University Hospital, Copen- hagen, DENMARK.



Molecular and Cellular Responses to Allergen 2:15 518 Allergen-Derived T-Cell Peptide Immunotherapy in Allergic

Asthmatic Individuals Is Associated with Induction of CD4+ IFN-gamma+/CD4+CD25+ T Cells and Enhanced Expression of TGF-beta and Notch-1 Ligands at Sites of Cutaneous Aller- gen Challenge C. Alexander l, J. Barkans i, L. Forsyth 2, Q. Meng t, S. Ying 1, A. Verhoef ], J. Lamb 2, A. B. Kay l, M. LarchO; 1Allergy and Clinical Immunology, NHLI Division, Imperial College London, London, UNITED KINGDOM, 2Respiratory Medicine Unit, University of Edinburgh Medical School, Edinburgh, UNITED KINGDOM.

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Effect of HLA-DR-Based T Cell Peptides Derived from Phos- pholipase A2 on Late-Phase Skin Reactions and T Cell Func- tion in Subjects with Mild Honeybee Allergy M, Tarzi l, C. Texier 2, B. Maill&e 2, M. Larch61, A. B. Kayl; tAllergy and Clinical Immunology, NHLI Division, Imperial Col- lege London, London, UNITED KINGDOM, 2Ing6nierie et d'E- tudes des Prot6ines, CEA-Saclay, Gif sur Yvette, FRANCE.

The Kinetics of Eotaxin-2 Release in Nasal Secretions Following Nasal Allergen Challenge: Its Inhibition by a Topical Steroid L, M. Teran I, L. Gonzalez z, E. Valencia-Maqueda 2, C. Negrete- Garcia2; IAllergy and Immunology, INER, Mexico, DE MEXICO, 2INER, Mexico, DE MEXICO.

Antigen-Specific Lymphocyte Proliferation and Cytokine Pro- duction Differentiate Children Who Have Outgrown Their Peanut Allergy G. Lack, K. Babb, V. Turcanu, Paediatric Allergy, Imperial College Faculty of Medicine, London, UNITED KINGDOM.

SP-A and SP-D Modulate the Allergic Sensitization by Varied Mechanisms: Investigations in Gene Deficient Mice T. M, Gupta I , U. Kishore 2, H. Clark 3, P. Strong 3, M. Singh I , K. B. M. Reid 3, P. U. Sarmal: ]Molecular Biochemistry and Diagnostics, Cen- tre for Biochemical Technology, Delhi, INDIA, 2Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxlbrd, Oxford, UNITED KINGDOM. 3Medical Research Council Immuno- chemistry Unit, University of Oxford, Oxford, UNITED KINGDOM.

Protective Role of a Recombinant Fragment of Human Surfac- tant Protein D (SP-D) Against Pulmonary Hypersensitivity in a Murine Model of Dust Mite Allergy M. K. Singh 1, T. M. Gupta l, B. C. Urban 2, U. P. Sarma j, U. Kishore2; 1Molecular Biochemistry and Diagnostics, Centre for Biochemical Technology, Delhi, INDIA, 2Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UNITED KINGDOM.

NK Cell-Dependent, Airway-Specific, Innate Eosinophilic Response to AIternaria in Mice K. Iijima, T. Kobayashi, H. Kita: Mayo Clinic, Rochester, MN.


4.'O0 525 A Causative Relationship Exists Between Eosinophils and the

Development of Allergic Pulmonary Pathologies N. A. Lee I, H. H. Shen 1, 2, J. R. Crosby 1, E. M. Hines t, M. T. Botchers 3, M. P. McGarry 3, S, I. Ochkur 3, T. L Biechele 1, K. R. O'NeilP, T. L. Ansay l, D. C. Colbert 3, S. A. Cormier 3, J. P. Jus- tice I, J. J. Lee3; IDepartment of Biochemistry and Molecular Biol- ogy, Division of Hematology/Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ, 2Respiratory Medicine, Zhejiang University Col- lege of Medicine, Hangzhou, CHINA, 3Department of Biochem- istry and Molecular Biology, Division of Pulmonary Medicine, Mayo Clinic Scottsdale, Scottsdale, AZ.

Immunotherapy 8:30 526

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Monday, March 10 8:30 AM to 10:30 AM

Protective Roles of Surfactant Proteins, SP-A and SP-D, in Lung Infection and Allergy U, Kishore 1, P. U. Sarma 2, M. Singh 2, B. C. Urban l, K. B. M. Reid 3, T. Madan2; lWeatherall Institute of Molecular Medicine. Oxford, UNITED KINGDOM, 2Centre for Biochemical Technolo- gy, Delhi, IND1A, 3MRC Immunochemistry Unit, Oxford, UNIT- ED KINGDOM.

Parietaria Pollen Sublingual Immunotherapy for Asthmatic Children: Seasonal Behavior in Methacholine PC20 G. B. Pajno, D. Vita, L. Caminiti, S. La Grutta, G. Barberio; Department of Pediatrics, University of Messina, Messina, ITALY.

Efficacy and Safety of a Standardized Sublingual Therapeutic Vaccine of Cat Epithelia Extract E. Gonzfilez, P. Berges, E. Aragoneses, C. Martin, E. AJvarez- Cuesta; Hospital "Ram6n y Cajal," Madrid, SPAIN.

Efficacy and Safety of a Therapeutic Vaccine Containing Depigmented and Glutaraldehyde-Polymerized Extracts of Dactylis glomerata and Olea europaea E. Aragoneses, C. Martfn, P. Berges, E. Gonz~ilez, E. Alvarez- Cuesta: Hospital "Ram6n y Cajal," Madrid, SPAIN.

Enhanced IL-10 Secretion by PBMC During the Ragweed Sea- son: Effect of AIC Immunotherapy vs Placebo E S. Creticos 1, S. S. Lighvani I, A. P. Bieneman j, S. L. Balcer- Whaley I, P. S. Norman t, L. M. Lichtenstein 2, J. T. Schroeder3; tAllergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Bal- timore, MA, 3Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltmore, MD.

10:15 533 Grass Pollen lmmunotherapy as an Effective Therapy for

Childhood Seasonal Allergic Asthma C. Hurley j, G. Roberts I, G. Lack2; IPaediatric Allergy, Asthma and Immunology, Imperial College at St. Mary's, London, UNIT- ED KINGDOM, 2paediatric Allergy, Asthma and Immunology, Imperial College at St. Mary's. London, UNITED KINGDOM.

Asthma Therapy 8JO 534

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Why Are We Still Decreasing the Dose of Allergy Shots After Local Reactions? 10:00 J. M, Kelso; Naval Medical Center, San Diego, CA. 540

In Vitro Allergen-Induced mRNA Expression of SLAM (Sig- naling Lymphocytic Activation Molecule) by PBMC of Patients with Allergic Rhinitis During Specific Immunotherapy K. Laaksonen l, J. Savolainen l, R. Lahesmaa 2, M. Junikka I , E. O. Terhol; I Department of Pulmonary Diseases and Clinical Allergol- ogy, University of Turku, Turku, FINLAND, :Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, FINLAND.

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Omalizumab Reduces the Rate of Asthma Deterioration-Relat- ed Incidents in Patients with Poorly Controlled Allergic Asthma J. G. Ayres I , R. Niven 2, G. Ayre 3, M. Blogg 3, H. Fox3; I Chest Research Unit, Heartlands Hospital, Birmingham, UNITED KINGDOM. 2North West Lung Research Centre, Manchester, UNITED KINGDOM, 3Novartis Horsham Research Centre, Horsham, UNITED KINGDOM.

Fluticasone Propionate (FP) CFC Delivered via Valved Holding Chamber with Facemask for 12 Weeks Improved Asthma Con- trol in Children Aged 24-47 Months with Asthma C, C, Crim j, R. A. Nathan 2, J. W. Baker 3, G. W. Bensch 4, M. A. Faris 5, N. E. Herje 5, C. A. Scott 5, W. Wu 5, C. C. Reisner 5: 1Respi- ratory Clinical Development and Medical Affairs, GlaxoSmithK- line, Research Triangle Park, NC, 2Asthma and Allergy Associates, Colorado Springs, CO, 3Allergy Associates Research Center, Port- land, OR, 4Bensch Research Associates, Stockton. CA, 5Glaxo- SmithKline, Research Triangle Park, NC.

Systemic Availability (Lung Deposition) of Drug From Two Dif- ferent Dry-Powder Inhalers in Children with Asthma S. Pedersen, L. Agertoft; Dept. of Pediatrics, Kolding Hospital, University of Southern Denmark, Odense, DENMARK.

Budesonide/Formoterol and Fluticasone/Salmeterol Combina- tion Inhalers Delay Immediate AIbuterol Recovery Following Acute Bronchoconstriction D. K. C. Lee, G. P. Cuttle, W. J. Cockburn, B. J. Lipworth; Asth- ma and Allergy Research Group, Dundee, UNITED KINGDOM.

Methacholine Challenge Causes Increased Excretion of Uri- nary Eosinophil Protein X in Asthmatic Children H. Lee, J. Oh, S. Shin, Y. Choi: Pediatrics. Hanyang Univ School of Medicine, Seoul, REPUBLIC OF KOREA.

Low-dose Enantiomeric Beta-agonists Modulate IL-6 Produc- tion in Human Airway Smooth Muscle Cells B. T, Ameredes, A. L. Gligonic, C. M. Neely, M. L. Robinson, W. J. Calhoun: Asthma, Allergy, and Airway Research Center: Div. of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

Dietary Intake, Atopy, and Wheeze at Age 3 Years: A Nested Case-Control Study C. S. Murray, B. M. Simpson, G. eoletti, A. Woodcock, A. Cus- tovic; North West Lung Centre, Manchester, UNITED KINGDOM.

Lung Function in Children Compared to Adults: A Cross-Sec- tional Study of Over 85,000 Measurements K. Paull I. M. Kraft 2, D. Gurka 2, J. Spahn2; IPediatrics, National Jewish Medical and Research Center, Denver, CO, 2National Jew- ish Medical and Research Center, Denver, CO.




Allergen Structure, Detection, and Control 8:30 542 IgE Response to Recombinant Allergens in Patients Sensitized

to Aspergillus in Asthmatics and Cystic Fibrosis V. P. Kurup 1, A. P. Knutsen 2, P. A. Greenberger 3, L. J. Castillo I ,

N. Elms I, M. B. Levy j, K. J. Kelly ~, J. N. Fink); Ipediatrics, Med- ical College of Wisconsin, Milwaukee, WI, 2Pediatrics, St. Louis University, St. Louis, MO, 3Medicine, Northwestern University

School of Medicine, Chicago, IL. 8:45 543

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Cat EN-RAGE: A New Allergen and a New Concept W. R. Thomas I , W. Smith 1, M. D. Chapman 2, A. J. Butler 1 , L. A. Hazell I, D. G. Nickels 1, K. L. Mills ~, B. J. Hales); Welethon Insti- tute for Child Health Research, Perth, AUSTRALIA, 2Indoor Biotechnologies, Charlottesville, VA.

European Variants of House Dust Mite Allergen Der f 2 A. Naudy, L. Graefe, I. Bormann, H. Kahlert, B. Weber, E M. Kni- est, O. Cromwell, H. Fiebig; R&D Department, Allergopharma Joachim Ganzer KG, Reinbek, GERMANY.

Molecular Cloning and Characterization of a Group 4 or-Amy- lase Blomia tropicalis Allergen K, T, Kuay, W. L. Wang, H. S. Shang, S. H. Lira, E T. Chew: National University of Singapore, Singapore, SINGAPORE.

Der fl Allergen Levels in The Netherlands: Misclassification of House Dust Mite Allergen Exposure in Studies Measuring Only Der pl? A. Pronk l, G. Doekes t, M. Hady 2, P. Steerenberg 3, J. van Amster- dam 3, B. Brunekreef]; qnstitute for Risk Assessment Sciences, University Utrecht, Utrecht, NETHERLANDS, 2Municipal Health Service, Utrecht, NETHERLANDS, 3National Institute for Public Health and the Environment, Bilthoven, NETHERLANDS.

Proteolytic Activity of House Dust--Exposure Levels in Homes J. Baker, P. Meighan, R. Pirzad, T. Cooke; Acaris Ltd, Cambridge, UNITED KINGDOM.

Efficacy of Extermination/Intensive Cleaning in Reduction of Cockroach Allergen in Inner-City North Carolina Homes M. Sever I , S. Arbes, Jr. I , J. C. Gore 2, L. Liu I , E. Long 3, J. Archer 3, E. Nuebler 4, M. Walter 4, H. Mitchell 4, C. Schal 2, D. C. Zeldinl;

JNIEHS/NIH, Research Triangle Park, NC, 2North Carolina State University, Raleigh, NC, 3CODA, Durham, NC, 4Rho, Inc, Chapel Hill, NC.

The Effect of Dehumidification/HEPA Filtration on Dew Point and Airborne Mold Spore Counts in Day Care Centers J .A. Bernstein 1 , M. S. Crandall 2, B. P. Lanphear 3, A. S. Perez 4, R. Floyd 1, L. Levine4; llnternal Medicine/Division of Immunolo- gy/Allergy Section, University of Cincinnati College of Medicine, Cincinnati, OH, 21ndoor Environmental Services, Cincinnati, OH, 3General Pediatrics/Division of Epidemiology, Children's Hospital Medical Center, Cincinnati, OH, 4Environmental Health, Universi- ty of Cincinnati College of Medicine, Cincinnati, OH.



Hot Topics in Anaphylaxis, Insect Sting Hypersensitivi(y, and Latex Allergy

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550 Intranasal Treatment with CpG Oligonucleotides Provides Protection from Anapbylaxis in a Murine Model of Peanut Allergy

J. D. Kattan, K. D. Srivastava, X. Li, H. A. Sampson; Pediatrics, Mount Sinai School of Medicine, New York, NY.

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Allergen Immunotherapy with Heat-killed Listeria Monocyto- genes (HKL) Abrogates Peanut Sensitivity/Anaphylaxis in Dogs O. L. Frick I, S. S. Teuber 2, B. B. Buchanan 3, S. Morigasaki 3, D.

T. Umetsu4; 1University of California, San Francisco, CA, 2Uni-

versity of California, Davis, CA, 3University of California, Berke-

ley, CA, 4Stanford University, Stanford, CA.

Occult Bone Marrow Mastocytosis Presenting as Recurrent Systemic Anaphylaxis C. Akin, D. D. Metcalfe Laboratory of Allergic Diseases, NIAID.

NIH, Bethesda, MD.

PAF Acetylhydrolase Deficiency Predisposes to Fatal Anaphylaxis P. Vadas ], M. Gold 2, G. Liss 3, C. Smith 2. J. Yeung 4, B. PerelmanS;

IMedicine, St. Michael's Hospital, University of Toronto, Toronto,

ON, CANADA, 2Hospital for Sick Children, Toronto, ON, CANADA, 3Government of Ontario, Ministry of Labour, Toronto, ON, CANA- DA, 4National Food Processors Association, Washington, DC, 5St.

Michael's Hospital, University of Toronto, Toronto, ON, CANADA.

Fire Ants Represent an Important Risk for Anaphylaxis Among Residents of an Endemic Region E. L. Caplan, J. L. Ford, P. E Young, D. R. Ownby; Allergy- Immunology Section, Medical College of Georgia, Augusta, GA.

Using Live Sting Challenge to Evaluate Efficacy of Reduced Maintenance Dose of IFA Immunotherapy in a Patient with Recurrent Systemic Reactions C. E. Thornblade, II, J. S. Nugent, L. L. Hagan; Allergy and

Immunology, Wilford Hall Medical Center. Lackland AFB, TX.

A Comparison of the UniCap test with an ELISA in the Diag- nosis of Individuals with Systemic or Severe Local Reactions to Mosquito Bites

Z. Peng, A. Beckett, Q. Wang, E. Simons; Pediatrics, University of Manitoba. Winnipeg, MB, CANADA.

Quantitative Allergenic Potency of Latex Gloves Reflected in Hev b 5 and Hev b 13 Contents H. Y. Yeang I , S. A. M. Arif I , Y. H. Loke I , M. Raulf-Heimsoth 2, R.

G. Hamilton3; LBiotechnology and Strategic Research Unit, Rub-

ber Research Institute of Malaysia, Kuala Lumpur, MALAYSIA, 2Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedi- zin (BGFA), Bochum, GERMANY, 3Johns Hopkins Asthma and

Allergy Center. Johns Hopkins University School of Medicine, Baltimore, MD.

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Monday, March 10 8 :30 A M to 10 :30 A M

Health Economics and Health Policy 8:30 558 Direet Costs of Allergen Immnnotherapy for Allergic Rhinitis

in the United States: Estimates from the 1996 Medical Expen- diture Panel Survey J. S. Sundy ] , A. W. Law 2, S. D. Reed 2, K. A. Schulman2; ] Division of Allergy and the Duke Clinical Research Institute, Duke Univer- sity Medical Center, Durham, NC, 2Center for Clinical and Genet- ic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.

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Costs and Health Care Utilization (HCU) in Adults with Asth- ma in a Hospital-based HMO" Influence of Poorly Controlled

Patients E. R. Soriano 1, R. G6mez 2, A. Scharfner I , D. Hares 1, A. Beratar- rechea I, E. Lifschitz ], S. Figar I, G. Machnicki 2, A. Castronuovo 2, A. De La CanaP, M. Marchetti l, E Gonzalez Bernaldo de Quirnsl;

IServicio de Clfnica M6dica y Gerencia M6dica Plan de Salud,

Hospital Italiano de Buenos Aires, Capital Federal, ARGENTINA, 2Novartis Argentina, Capital Federal, ARGENTINA, 3Secci6n Neumonologfa, Servicio de Clfnica M6dica, Hospital Ita]iano de Buenos Aires. Capital Federal, ARGENTINA.

Use of Long-Term Asthma Controller Medications Before and After a Hospitalization or Emergency Department Visit A. Atherly 1, S. G. Williams2; ]Health Policy and Management, Emory University, Atlanta, GA, 2National Center for Environmen- tal Health, Centers for Disease Control, Atlanta, GA.

Inapparent Non-adherence to Inhaled Corticosteroids Regi- mens for Bronchial Asthma M. S. Kaplan; Permanente Med., Oakland, CA.

The Cost of the underdiagnosis of Asthma C. L. Walker: Medicine, Northwestern University, Chicago, IL.

Comparison of Healthcare Costs after Treatment with Inhaled Corticnsteroids (ICSs) and Leukotriene Receptor Antagonists (LTRAs) for Asthma B. Parasuraman j, L. McDermott I, C. Roberts 2, T. McLaughlin3;

IAstraZeneca LP, Wilmington, DE, 2NDCHealth, Yardley, PA, 3NDCHealth, Phoenix, AZ.

Underuse of Allergen Sensitization Evaluation and Trigger Avoidance Education among Inner-city Adults with Persistent Asthma E. A. Halm 1,2, P. J. Busse 2,3, J. Wang l; t Department of Health Policy,

Mount Sinai School of Medicine, New York, NY, 2Mount Sinai Hos- pital, Department of Medicine, New York, NY, 3Department of Clini-

cal Immunology, Mount Sinai School of Medicine, New York, NY.

National Environmental Health Tracking Network is Necessary to Combat Increasing Rates of Asthma Throughout the Country

M. G. Chuk, L. Rasar King; Physicians for Social Responsibility, Washington, DC.



Effector Cells of Allergic Disease." What's New and Exciting? 8:30 566 Regulation of the Aetivin A Expression in Mast Cells and Asth-

ma: Its Effect on the Proliferation of Human Airway Smooth Muscle Cells S. H. Cho 1, Z. Yao 2, S. Wang 2, R. E Alban ], S. W. French 3, C. K. Oh]; I Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, 2Tanox Inc, Houston, TX, 3pathology, Harbor-UCLA Medical Center, Torrance, CA.

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FccRI-Dependent Growth Gene Induction in Human Mast Cells is Differentially Controlled by T Helper Type 2 Cytokines J. A. Boyce I, K. S. Price 2, M. Briskin 3, M. Hodge 3, J. Lora3; IRheumatology, Immunology and Allergy, Brigham & Women's Hospital, Boston, MA, 2Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, 3Millennium Phar- maceuticals, Inc, Cambridge, MA.

Characterization of Novel Stem Cell Factor Responsive Human Mast Cell Lines LAD ! and 2 Established from a Patient with Mast Cell Sarcoma/Leukemia; Activation Following Aggrega- tion of FceRI and Fc~RI A. S. Kirshenhaum ~, C. Akin I, Y. Wu I, A. Gilfillan I, J. P. Goff 2, D. /3. Golden 3, D. D. Metcalfet; ILad. NIAID, Bethesda, MD, 2Radiation Ontology, University of Pittsburgh, Pittsburgh, PA, 3Asthma and Allergy Center, Johns Hopkins, Baltimore, MD.

Modulation of Basophil Function by Leukocyte lmmunoglobu- lin.like Receptors (LIRs) D. E. Sloane I , N. Tedla 2, M. Awoniyi 3, D. W. MacGlashan, Jr. 4, K. Austen I, J. P. Arml; rDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, 2Department of Pathology, University of New South Whales, Sydney, AUSTRALIA, 3Beloit College, Beloit, WI, 4Asthma and Allergy Center, Johns Hopkins Universi- ty, Baltimore, MD.

Eosinophil SNAREs Are Critical Components for Eosinophil Peroxidase (EPO) Release and Are Associated with the Secl/Muncl8 (SM) Regulator, Muncl8c M. R. Logan, S. O. Odemuyiwa, P. Lacy, R. Moqbel; Medicine, University of Alberta, Edmonton, AB, CANADA.

Modulatory Role of Human Blood Eosinophils in Angiogenesis: Ex Vivo and In Vitro Studies I. Puxeddu 1, A. Allan 2, A. M. Piliponsky ], A. Panet 2, E Levi- Schafferl; 1Department of Pharmacology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, ISRAEL, 2Department of Virology, Faculty of Medicine, The Hebrew Uni- versity of Jerusalem, Jerusalem, ISRAEL.

CD9 Physically Associates with CDllb/CD18 Integrin and Regulates Adhesion and Activation of Human Eosinophils A. Terada, K. lijima, H. Kita: Medicine, Mayo Clinic, Rochester, MN.

Airway Epithelial Cell Activation and Toll-like Receptors (TLR) Q. Sha, J. R. Plitt, N. M. Heller, L. A. Beck, F. lmani, R. P. Schleimer; Medicine. Johns Hopkins University, Baltimore, MD.


Poster Session 4501

Monday, March 10 10:45 AM to 11:45 PM

Outcomes Studies in Allergic Respiratory Disease 574 Impact of a Randomized Asthma Education Program on Asth-

ma Control in Children A. B. Becker 1, D. Whitters 2, C. A. Gillespie 3, S. E. Filuk 3, J. E. McColm 3, N. J. Thomas 3, M. P. Piwniuk 3, E R. Simons l, W. T. A. Watsonl; 1Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, CANADA, 2UniverSity of Manitoba, Winnipeg, MB, CANADA, 3Children's Asthma Education Centre, Children's Hospital of Winnipeg, Winnipeg, MB, CANADA.

575 Psychological Profiles of Adult Asthmatic Patients with or without Childhood Asthma M. Haida, Y. Tsuchikawa; Internal Medicine, Hanzomon Hospital, Tokyo, JAPAN.

576 Asthma-related Healthcare Utilization in Patients Initiating Fluticasone Propionate (FP) and Montelukast Sodium (MON) E C. AIlen-Ramey, S. Sajjan, P. T. Duong, L. E. Markson; Merck & Co, Inc, West Point, PA.

577 Longitudinal Patterns of Asthma Care in Preschool Children in a Medicaid Population L. M. Nelsen I, S. Munns 2, J. Whitmire 3, R. Balkrishnan 4, N. C. Santanello~; tEpidemiology, Merck & Co, Inc, West Point, PA, 2School of Medicine, University of Iowa, Iowa City, 1A, 3State Center for Health Statistics, North Carolina Dept of Health, Raleigh, NC, 4Dept of Public Health Sciences, Wake Forest Uni- versity School of Medicine, Winston-Salem, NC.

578 Comparative Study of 3 re Generation Cephalosporin Antibiot- ic and Amoxicillin or TMP-sulfa in Treatment of Sinusitis R. Olson, D. Bukstein, A. Luskin; Dean Foundation for Health, Research and Education, Middleton, WI.

579 A Survey of [32-Agonist Inhaler Availability for Children with Asthma during Organized Sporting Events I. D. Cardona I, G. E. D'Alonzo, Jr. 2, J. M. Becker3; JPediatrics, Drexel College of Medicine, Philadelphia, PA, 2pulmonary and Critical Care, Temple University School of Medicine, Philadelphia, PA, 3pediatrics, Chief Section of Allergy, Drexel College of Medi- cine, Philadelphia, PA.

580 Efficacy of Inhaled Corticusteroids in Combination with a Long Acting Beta2-Agonist in Asthmatic Children Under 5 S. Sekhsaria, M. Alam; Union Memorial Hospital, Baltimore, MD.

58"1 National Design of "Asthma Registry Plan" and Evaluation of Its Integration into Health Care Networks in I ran M. Gharagozlou; Immunology and Allergy Research Center, Tehran University of Medical Sciences, Tehran, IRAN (ISLAMIC REPUBLIC OF).

582 A Patient Satisfaction Survey Comparing Levaibuterol to Racemlc Albuterel in Children W. E. Berger I, D. Ames2; 1Southern California Research Center, Mission Viejo, CA, 2Sepracor, Marlborough, MA.

583 Yearly Peak in Pediatric Asthma Admissions in Canada C. A. Gillespie l, S. Kapur 2, A. Avery 2, M. Tillett 3, A. B. Becker3; IChildren's Asthma Education Centre, Children's Hospital of Win- nipeg, Winnipeg, MB, CANADA, 2University of Dalhousie, Hali- fax, NS, CANADA, 3Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, CANADA.

584 Development of the Asthma Control Test (ACT) R. A. Nathan 1, C. Sorkness 2, J. T. Li 3, M. Schatz 4, P. Marcus 5, J. Murray 6, M. Kosinski7; JAsthma and Allergy Associates and Research Center, Colorado Springs, CO, 2School of Pharmacy, University of Wisconsin, Madison, WI, 3Mayo Medical Center, Rochester, MN, 4Kaiser-Permanente Medical Center, San Diego, CA, 5New York College of Osteopathic Medi~:ine. Old Westbury,

NY, 6Vanderbilt University Medical Center, Nashville, TN, 7Qual- ityMetric, Inc, Lincoln, RI.

585 Impact of Nocturnal Asthma Symptoms on Parents of Inner City Children G. B. Diette I, C. Rand 2, L. Swartz 3, A, Butz 4, S. Kanchanaraksa 5, J. Brosnan 4, P. Eggleston4; JMedicine, Johns Hopkins University, Baltimore, MD, 2Medicine, Johns Hopkins University, Baltimore, MD, 3Johns Hopkins University, Baltimore, MD, 4pediatrics, Johns Hopkins University, Baltimore, MD, 5Epidemiology, Johns Hopkins University, Baltimore, MD.

586 Nocturnal Nasal CPAP Use Improves Respiratory Function in Moderate to Severe Asthma N. Edwards l, D. M. Blyton I, T. O'Meara I, L. Poulos 1, J. D. Bran- nan 2, C. E. Sullivan I; 1Department of Medicine, The University of Sydney, Sydney, AUSTRALIA, 2Department of Respiratory Med- icine, Royal Prince Alfred Hospital, Sydney, AUSTRALIA.

587 The Development of Respiratory Allergy in Children with Food Sensitivity S. Huang; Pediatrics, University of Florida College Medicine, Gainesville, FL.

Poster Session 4502


Asthma Mechanisms: Anti-inflammatory Therapy 588 Evaluation of Patients' Preferences for Triamcinolone Ace-

tonide AQ, Flutieasone Propionate, and Mometasone Furnate Nasal Sprays in Patients with Allergic Rhinitis L. Dupclay 1, D. Thompson 2, M. Stokes 2, G. Georges3; 1Health Economics and Outcomes Research, Aventis Pharmaceuticals, Bridgewater, N J, 21nnovus Research, Inc, Medford, MA, 3Aventis Pharmaceuticals, Bridgewater, NJ.

589 Role of Allergy and Inflammation in Nasal Polyps and Sinusitis J. Hao l, Y. Pang 2, D. Wang2; J Otolaryngology, National Universi- ty of Singapore, Singapore, SINGAPORE, 2Department of Oto- laryngology, National University of Singapore, Singapore, SIN- GAPORE.

590 High Doses of the Novel Inhaled Steroid Ciclesonide Have No Effect on HPA-axis Function in Patients with Moderate-to- Severe Persistent Asthma S. J. Szefler I , J. Herron 2, M. Lloyd 3, S. Rohatagi 3, J. E. Williams 3, S. Kundu 3, D. Banerji 3, 1Pediatrics, National Jewish Medical & Research Center, Denver, CO, 2Arkansas Research Center, Little Rock, AR, 3Aventis Pharmaceuticals, Bridgewater, NJ.

591 Lung Deposition and Distribution of Flunisolide-HFA, Assessed by Gamma Scintigraphy and Single Photon Emission Computed Tomography (SPECT) S. E Newman 1, D. A. Clark I , C. S. Kalirai I, G. R. PitcairnJ, P. H. Hirst I , W. T. Abramowitz 2, R. Kapil 2, J. Rosenberg 2, K. Newman2; Ipharmaceutical Profiles, Nottingham, UNITED KINGDOM, 2Forest Laboratories, New York, NY.

592 Anti-inflammatory Effect of Tecastemizole on Nasal Epithelial Cell (NEC) Production of IL-8, IL-lb, and Nitric Oxide (NO) M. Frieri j, B. May2; JDivision of Allergy Immunology, Depart- ment of Medicine and Pediatrics, Nassau University Medical Cen- ter, East Meadow, NY, 2Microbiology, New York College of Osteo- pathic Medicine, New York Institute of Technology, Old Westbury, NY.

593 Pharmacokinetics of Ciclesonide and Its Active Principle in Asthma Patients and Healthy Subjects After Single-Dose Inhalation 3". D. Bethke I, R. Nave I , K. Zech j, K. A. Gunawardena2; IAltana Pharma AG, Konstanz, GERMANY, 2Chiltern International Limit- ed, Buckinghamshire, UNITED KINGDOM.

$ 3 8 4 Abs t rac ts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

594 An Evaluation of Short-Term Corticosteroid Response in Perennial Allergic Rhinitis Using Histamine and Adenosine Monophosphate Nasal Challenge A. M. Wilson, E. J. Sims, L. C. Orr , F. Robb, B. J. Lipworth; Clin- ical Pharmacology, University of Dundee, Dundee, UNITED KINGDOM.

595 Once-Daily Evening Dosing with Mometasone Furoate Dry- Powder Inhaler Reduces Overnight and Early Morning Symp- toms of Mild to Moderate Asthma J. Corren [ , P. V. Perin 2, S. P. Galant 3, H. Staudinger 4, H. Sacks4; 1Allergy Research Foundation, Inc, Los Angeles, CA, 2The Medical Center at Willowbrook, Wayne, N J, 3Clinical Trials of Orange Coun- ty, Orange, CA, 4Schering-Plough Research Institute, Kenilworth, NJ.

596 Ciclesonide, a Novel Inhaled Steroid, Has No Effect on Hypo- thalamic-Pituitary-Adrenal (HPA)-axis Function in Mild-to- Moderate Asthmatics C. F. LaForce% J. W. Baker 2, D. Amin 3, S. Rohatagi 3, P. Mendes 3, J. Williams 3, S. Kundu 3, D. Banerji3; INorth Carolina Clinical Research, Chapel Hill, NC, 2Asthma, Allergy and Dermatology Research Center, Lake Oswego, OR, 3Aventis Pharmaceuticals, Bridgewater, NJ.

597 Effects of Once-Daily Evening Dosing with Mometasone Furoatc Dry-Powder Inhaler on Symptom Control in Mild to Moderate Asthma A. D'Urzo t, B. Prenner 2, M. Vandewalker 3, H. Staudinger 4, H. Sacks4; tPrimary Care Lung Clinic, Madison, Wl, 2Allergy Asso- ciate Medical Group, lnc, San Diego, CA, 3Clinical Research of the Ozarks, Rolla, MO, 4Schering-Plough Research Institute, Kenilworth, NJ.

598 PK/PD of Inhaled Corticosteroids: The Risk/Benefit of Inhaled Ciclesonide S. Rohatagi 1, H. Derendorf 2, K. Zech 3, R. Nave 3, D. Banerjil; I Aventis Pharmaceuticals, Bridgewater, N J, 2University of Florida, Gainesville, FL, 3ALTANA Pharma, Konstanz, GERMANY.

599 Triamcinolone Acetonide Aqueous (TAA AQ) and Fluticasone Propionate (FP) Nasal Sprays Show Equivalent Relief of Total Symptom Scores Regardless of Disease Severity H. B, Kaiser 1, T. Woodworth 2, Y. Liao 2, J. Garcia 2, G. Georges2; IClinical Research Institute, Minneapolis, MN, 2Aventis Pharma- ceuticals, Bridgewater, NJ.

600 Efficacy and Safety of One-Puff, Once-Daily, Evening Treat- ment with Mometasone Furoate Dry-Powder Inhaler 400 meg Compared with Fluticasone Propionate Metered Dose Inhaler 125 mcg Two Puffs, Twice Daily in Asthma Patients Switched from Fiuticasone Propionate P. Lar ivre 1, J. Eller 2, N. Crimi 3, C. Picado 4, A. Wardlaw 5, L. Ghaly 6, A. G. Harrisr; ICenter Hospitalier Universitaire de Sher- brooke, Sherbrooke, PQ, CANADA, 2Markt 1, Belin, GERMANY, 31nstituto di Malattie dell'Apparato Respiratorio Universita di Can- tina, Cantina, ITALY, 4Hospital Clinici Provincial, Barcelona, SPAIN, 5Glenfield Hospital NHS Trust, Leicester, UNITED KINGDOM, 6Integrated Therapeutics Group, Kenilworth, NJ.

601 Fluticasone Propionate is Safe in Treating Pre-School Age Chil- dren (24-47 Months) with Asthma R. L. Wasserman t, K. T. Kim 2, K. V. Blake 3. N. E. Herje 4, C. A. Scott 4, W. Wu 4, C. C. Crim 4, E H. Barnhart 4, C. C. Reisner4; IPedi- atric Allergy and Immunology Assoc., EA., Dallas, TX, 2West Coast Clinical Trials, Long Beach, CA, 3The Nemours Children's Clinic, Jacksonville, FL, 4GlaxoSmithKline, Research Triangle Park, NC.

602 The Ability of Children to Use Dry-Powder Inhalers S. Ones, Z. Tamay, E. Kirerleri, N. Guler; Department of Pedi- atrics, Division of Pulmonology and Allergy, Istanbul Medical Fac- ulty, Istanbul, TURKEY.

603 Allergist and Pulmonologist Prescribing of Inhaled Corticos- teroids for Pregnant and Nonpregnant Women W.ith Asthma N. K. Ostrom l, P. Park 2, M. Cmz-Rivera2; IAllergy and Asthma

Medical Group and Research Center, A.P.C., San Diego, CA, 2AstraZeneca, Wilmington, DE.

604 The Effect of Budesonide Encapsulated in Liposomcs on Air- way Hyperresponsiveness in Experimental Asthma S. D. Nandedkar L K. S. Konduri I, D. A. Rickaby 2, N. Duzgunes3; I Pediatrics, Medical College of Wisconsin, Milwaukee, W1, 2phys- iology, Medical College of Wisconsin, Milwaukee, W1, 3physiolo- gy/Microbiology, University of the Pacific School of Dentistry, San Francisco, CA.

605 Determinants of Airway Hyperresponsiveness in Mild Asthma C. M. Jackson, G. P. Currie, D, C. Lee, B. J. Lipworth; Asthma & Allergy Research Group, Clinical Pharmacology & Therapeutics, Ninewells Hospital & Medical School, Dundee, UNITED KING- DOM.

606 Oropharyngeal Deposition of Inhaled Ciclesonide and Bndes- onide in Healthy Subjects R. Nave, K. Zech, T. D. Bethke; Altana Pharma AG, Konstanz, GERMANY.

607 Hoarseness Secondary to Inhaled Corticosteroids (ICS) Suc- cessfully Treated with QVAR H. M. Yeates; private practice, Orem, UT.

608 Significant Improvement in an Adolescent with Severe Steroid- Dependent Asthma Following Clarithromycin Therapy M. A. Cavuoto, B. Kaplan; Division of Allergy/Immunology, North Shore-Long Island Jewish Health Care System, New Hyde Park, NY.

Poster Session 4503


Immunodeficiency 609 Long Term Survival in Perinatal HIV Infection

S. Radinsky I, S. Schuval2; IDepartment of Allergy & Immunolo- gy, North Shore-Long Island Jewish Health Care System, New Hyde Park, NY, 2North Shore-Long Island Jewish Health Care System, New Hyde Park, NY.

610 Effect of a Multisystemic Therapy Program on Pediatric HIV Medication Adherence as Measured by Viral Load I. Badr% C. Rongkavilit ~, S. Naar-King 2, E. Moore 1, E. Secord3; iWayne State University, Children's Hospital of Michigan, Detroit, MI, 2Wayne State University, Children's Hospital of Michigan, Detroit, ML 3Children's Hospital of Michigan, Wayne State Uni- versity, MI.

611 Evaluation of TSE Clearance by the Filtration Process of a New Intravenous Immunogiobulin Product (Gamunex TM, 10%) C. StenlandL J. TerryL K. Cai I, M. Nelson% R. Hartwell 1, R. Rubenstein 2, S. Petteway, Jr.l; IDepartment of Pathogen Safety Research, Bayer Corporation, Research Triangle Park, NC, 2Department of Virology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY.

619 Frequency of the 10 Warning Signs among Patients with Pri- mary Humoral Immune Deficiences R, W. Hendershot, S. K. Watters, M. C. Zacharisen, K. J. Kelly; Allergy, Medical College of Wisconsin, Milwaukee, Wl.

613 Interferon Alpha Treatment for Disseminated M. avium Com- plex (MAC) Infection in Complete Interferon Gamma Recep- tor 2 Defciency G. Uzel I, K. R. Hirsch 2, T. A. Fleisher 2, S. M. Holland3; 1Depart- ment of Pediatric Immunology and Rheumatology, Children's Memorial Hospital, NWU, Chicago, IL, 2CC, DLM, Immunology, NIH, Bethesda, MD, 3NIAID, LHD, NIH, Bethesda, MD.

614 Common Gamma Chain Mutation R222C Causes Atypical Severe Combined Immunodeficiency (SCID) Phenotype M. Triassi, C. Roifman; Immunology and Allergy, The Hospital for Sick Children, Toronto, ON, CANADA.

J ALLERGY CLIN/MMUNOL Abst rac ts $385 VOLUME 111, NUMBER 2

615 Pretransplant Lymphoproliferative Disease in an Infant with Severe Combined lmmunodeficiency (SCID) L. J. KobrynskP, C. Abramowsky2; 1Pediatrics, Emory Universi- ty, Atlanta, GA, 2Pathology, Emory University, Atlanta, GA.

616 Increased Apoptosis in Monocytes of XLA Patients Stimulated with Pneumococcal Antigen E R. Vallejos j, E. J. Saturno 2, C. M. Moore 2, R. U. Sorensen 2. A. Ochoa2,3; 1Pediatrics, LSU Health Sciences Center, New Orleans, LA, 2pediatrics, LSU Health Science Center, New Orleans, LA, 3Tumor Immunology Program, Stanley S. Scott Cancer, LSU Health Science Center, New Orleans, LA.

617 The Affects of an Aged Immune System on HIV: The Course of HIV in Elderly Patients Compared with a Younger Group When Aggressive Highly Active Antiretroviral Therapy is Instituted N. Sharma I, M. Lee-Wong2; IDepartment of Internal Medicine, Beth Israel Medical Center, New York, NY, 2Divison of Clinical Immunology and Allergy, Beth Israel Medical Center, New York, NY.

618 Immune Response to Hepatitis A Vaccination in HIV Positive Patients H. Yarmohammadi j, C. Feucht 2, S. Weissman3; ]Allergy and Immunology, Mt. Sinai Hospital, New York, NY, eLouis Stokes Cleveland VAMC, Cleveland, OH, 3St. Raphael Hospital, New Haven, CT.

619 Bone Marrow Transplantation without Myeloablative Condi- tioning in a Child with Severe Combined Immunodeficiency Pre-treated with PEG-ADA E. T. Chu l, R. Shames I, E. G. Loewy l, M. S. Hershfield 2, M. J. Cowan 3, D. T. Umetsul; IPediatric Allergy, Asthma, and Immunol- ogy, Stanford University, Stanford, CA, 2Department of Rheuma- tology and Immunology, Duke University, Durham, NC, 3Depart- ment of Pediatrics/Division of Bone Marrow Transplant, University of California-San Francisco, San Francisco, CA.

620 Stability of a New Liquid Intravenous Immunoglobulin Prepa- ration (IGIV-C 10%) Manufactured Using a Novel Production Process C. Schreiner, S. Beck; Biological Products. Bayer Corporation, Clayton, NC.

621 Clinical Presentation of Five Patients with Idiopathic CD4+ T- Lymphocytopenia L. J. B. Davis, C. R. Weiler; Allergy, Mayo Clinic, Rochester, MN.

622 Common Variabl e Immunodeficiency (CVID) Presenting with Bronchiolitis Obliterans with Organizing Pneumonia (BOOP) J. Lynn, R. Wodell, A. I. Levinson; University of Pennsylvania, Philadelphia, PA.

1523 Successful Unrelated Donor Cord Blood Transplantation in a Thai Boy with Wiskott-Aidrich Syndrome A. Chewataworn I, P. Chatchatee 2, P. Vanichsetakul 2, J. Ngam- phaiboon3; ~Department of Pediatrics, Chulalongkorn University, Bangkok, THAILAND, 2pediatrics, Chulalongkorn University, Bangkok, THA'ILAND, 3Chulalongkorn University, Bangkok, THAILAND.

624 X-Linked Agammaglohulinemia (XLA) and Growth Distur- bance P. D. Jantzi , F. C. Schmalstieg; University of Texas Medical Branch, Galveston, TX.

625 An Unusual Combination of Abnormal Neutrophil Oxidative Function, Neutropenia, and Severe Anemia P. VenkateshL J. M. EI-Dahr2; JAllergy and Immunology, Tulane University Medical Center, New Orleans, LA, 2Pediatric Allergy/Immunology/Rheumatology. Tulane University Medical Center, New Orleans, LA.

626 Study on Diagnosis and Treatment to Patients with Hereditary Angioedema Y. X, Zhi, H. Y. Zhang; Department of Allergy, Peking Union Med- ical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, CHINA.

627 Interferon- 7 Receptor-2 Deficiency Presenting with Cytomega- Iovirus Infection A. M. Scuriock I , S. G. Shaw I, S. D. Rosenzweig 2, E, O. Sajaroff I, S. M. Holland 2, R. H. BuckleyJ; IDepartment of Pediatric Aller- gy/Immunology, Duke University Medical Center, Durham, NC, 2National Institutes of Health, Bethesda, MD.

628 Comparison of New Methods for Assessing Cell-Mediated Immune Responses C. W. Thurm, P. Hembree. S. Manna, J. F. Halsey; IBT Reference Laboratory, Lenexa, KS.

629 Tuberculin Test--A Good Tool in HIV Positive Patients B. D. Dalai t, P. Garg 2, P. Dalai 3, H. Desai 3, S. Sheth 4, R. PatelS; ~tnternal Medicine. K G ID Institute, Ahmedabad, INDIA, 2B. J. Medical College, Ahmedabad, INDIA, 3Smt. N. H. L. Municipal Medical College, Ahmedabad, INDIA, 4Johns Hopkins Institute, Baltimore, MD, 5M. E Shah Medical College, Jamnagar, INDIA.

630 Natural Killer Cells in Mucocutaneous Candidiasis M. L. Paima-Carlos; Center for Hematology and Immunology, Institute of Immunology, Lisbon University Hospital, Lisboa, PORTUGAL.

631 Tolerability of a New Intravenous Immunoglobulin Prepara- tion (IGIV) in Pediatric and Adult Patients K. Hanna & the IGIV-C Study Group; Biological Products, Bayer Corporation, Research Triangle Park, NC.

632 Tolerability of Rapid Infusion Administration of a Novel IGIV Preparation ([GIV-C, 10%) in Patients with Chronic Idiopath- ic Thrombocytopenic Purpura (ITP) J. B. BusseP, K. Hanna, & the IGIV-C in ITP Study Group2; IDepartment of Pediatrics, New York Presbyterian Hospital, New York, NY, 2Biological Products, Bayer Corporation, Research Tri- angle Park, NC.

633 Pharmaeokinetics of Intravenous Immunoglobulin Adminis- tered via Subcutaneous Route in Patients with Hypogamma- globulinemia C. Tant imongkolsuk I, T. Arkachaisri 1. N. Visitsunthorn I, A. Wongkajornsilp 2, P. Vichyanond]; I Department of Pediatrics, Fac- ulty of Medicine, Siriraj Hospital, Bangkok, THAILAND, 2Department of Pharmacology, Faculty of Medicine, Siriraj Hospi- tal, Bangkok, THAILAND.

634 Clinical Utility of Anergy Testing in Conjunction with Purified Protein Derivative (PPD) Testing S. A. Armogida, L. Pien; Allergy and Immunology, Cleveland Clinic Foundation, Cleveland, OH.

635 Intraspinai Sarcoidosis and Common Variable Immune Deft- ciency--Case Report and Literature Review A. Madaan, C. R. Weiler; Division of Allergy & Immunology, Mayo Clinic, Rochester, MN.

636 Common Variable Immunodeficiency: Two Subgroups Defined by lgE Levels C. L. Brown 1. R. D. Thomas 2, Z. Ballas3; 1Department of Aller- gy/Immunology and Department of Otolaryngology, University of Iowa Hospital and Clinics, Iowa City, IA, 2Department of Oto- laryngology, University Of Iowa Hospital and Clinics, Iowa City, 1A, 3Department of Allergy~Immunology, University of Iowa Hos- pital and Clinics, Iowa City, IA.

637 Movement Disorder in a Patient with Hyper IgM Syndrome R. G. Piltch, R. Boustany, L. Williams: Duke University Medical Center, Durham, NC.

638 Beneficial Effect of an Amino-Acid Based Formula for Neona- tal Eosinophilic Folliculitis Associated with Hyper-IgE Syn- drome and Cow's Milk Allergy V. E Hernandez-Trujillo ] , J. T. Belleau 1, W. T. Nguyen I , M. Jeng 2, M. E. Conley 1,3, D. B. Lewl; IPediatric Allergy/Immunology, Uni- versity of Tennessee. Memphis, TN, 2Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN. 31mmunology, St. Jude Children's Research Hospital, Memphis, TN.


639 Von Willebrand Disease Type III and Diminished Response to Bacteriophage phiX174 Testing T. H. Sher j, N. Wasserbauer 2, R. W. Hostoffer, Jr.3; ICase Western Reserve University, Highland Heights, OH, 2Chicago College of Osteopathic Medicine, Chicago, IL, 3Case Western Reserve Uni- versity, Cleveland, OH.

640 Immune Deficiency in VACTERL Syndrome Complicating Chylothorax N. KashemsrP, K. E. Georgeson 2, T. P. Atkinsonl; JPediatrics, University of Alabama at Birmingham, Birmingham, AL, 2Surgery, University of Alabama at Birmingham, Birmingham, AL.

641 Trimethopr im-Sulfamethoxazole (TMP-SMX)-Associa ted Neutropenia in a Patient with X-linked Hyper IgM Syndrome (XHIM) D. B. Coyle, M. B. Fasano; Allergy/Immunology, Wake Forest University School of Medicine, Winston-Salem, NC.

642 Trisomy 18 Associated with Combined Immune Deficiency F. O. Seeborg, W. T. Shearer, L. M. Noroski; Texas Children's Hospital, Allergy & Immunology, Baylor College of Medicine, Houston, TX.

643 Common Variable Immunodeficiency Presenting as Burkitt's Lymphoma in a 12-Year-Old Boy S. Judge ], I. Badr 2, E. Secord2; IWayne State Univ/Children's Hospital of Michigan, Detroit, MI, 2Wayne State Univ/Children's Hospital of Michigan, Detroit, MI.

644 Headache in Patients with Primary Antibody Deficiency Receiving Intravenous Gammaglobulin (IVIG) Replacement Therapy L. A. Nelson l, K. Athenas 2, L. Fontana j, S. Reddy 2, G. Tietjen2; ipediatrics, Medical College of Ohio, Toledo, OH, 2Neurology, Medical College of Ohio, Toledo, OH.

645 Clinical and Laboratorial Aspects of the Chronic Granuloma- tous Disease (CGD) in Childhood: Evaluation of Patients E. M. G. Carnide, C. M. A. Jacob, A. C. Pastorino, A. B. M. Castro; Dept. of Pediatrics, University of Sao Paulo, San Paulo, BRAZIL.

646 Cellular lmmunodeficiency and Autoimmunity Associated with Chronic Mineral Oil Administration W. Chen, L. Yel, D. Giannakopoulos, S. Gupta; Medicine/ Immunology, University of California, lrvine, CA.

647 Specific Antibody Deficiency Unmasked in a School Aged Child J. E Villacis j, J. W. Walsh 2, J. M. EI-Dahr3; JAllergy, Immunolo- gy and Rheumatol0gy, Tulane University Health Sciences Center, New Orleans, LA, 2Neurosurgery, Tulane University Health Sci- ences Center, New Orleans, LA, 3pediatric Allergy, Immunology, and Rhenmatology, Tulane University Health Sciences Center, New Orleans, LA.

648 New-Onset Egg Allergy as a Result of Immune Reconstitution in an HIV-Positive Patient J. J. P rochnau 1, A. W. Urban 2, R. K. Bushl; iAllergy and Immunology, University of Wisconsin, Madison, Wl, 21nfectious Diseases, University of Wisconsin, Madison, WI.

649 Evans Syndrome and Bacteriophage Testing N. Wasserbauer j , J. Underwood 2, A. Kuper 3, C. Backes 3, R. W. E. Hostoffer4; JChicago College of Osteopathic Medicine, Downers Grove, IL, :Ohio University College of Osteopathic Medicine, Athens, OH, 3Ohio College of Osteopathic Medicine, Athens, OH, 4Case Western Reserve University, Cleveland, OH.

650 Reconstitutiou of Immunoglobulin Production in a Patient with Common Variable Immunodeficiency Syndrome after Developing Insulin Dependent Diabetes J. M. El-Dahr i, B. V. Gill 2, J. B. Prather 3, E. E. Chang4; ISection of Clinical Immunology, Allergy and Rheumatology, Tulane Uni- versity Health Science Center, New Orleans, LA, 2Tulane Univer- sity Health Science Center, New Orleans, LA, 3prather Clinic, Opelousas, LA. 4Clinical Immunology, Allergy and Rheumatology, Tulane University Health Science Center, New Orleans, LA.

651 Multiple Esophageal Ulcerations in a Patient with Severe Com- bined Immunodeficiency M. A. Koleilat 1, W. J. Cochrane 2, L. W. Williams3; JPediatrics, Geisinger Medical Center, Danville, PA, 2pediatrics-Gastroenterol- ogy, Geisinger Medical Center, Danville, PA, 3pediatric Allergy and Immunology, Duke University Medical Center, Durham, NC.

652 Effectiveness of the Serology Anti Helicobaeter Pylori as Diag- nostic Method in Infected Patients With HIV Versus Technical of Amplification of the DNA (Polimerase Chain Reaction) C. Maria de los R 1, G. Sandra 2, F. Maria Elisa 2, P. Angela 3, P. Mariela4; 1Unidad de Inmunologia, Universidad de Carabobo, Valencia, VENEZUELA, 2Universidad de Carabobo, Valencia, VENEZUELA, 3Centro M6dico Guerra Mendez, Valencia, VENEZUELA, 4Ciudad Hospitalaria Enrique Tejera, Valencia, VENEZUELA.

653 Immunodeficiency in Jacobsen Syndrome C. D. E. Miller I, A. R. Atkinson 2, C, M. Roifman3; qmmunology/Allergy, The Hospital for Sick Children, Toronto, ON, CANA- DA, 2Immunology/Allergy, The Hospital for Sick Children, Toron- to, ON, CANADA, 31mmunology/Allergy and the Infection, Immunity, Injury and Repair Program, The Hospital for Sick Chil- dren, Toronto, ON, CANADA.

654 Three-Month-Old Male with Str idor J. B. Kim, A. M. Staveren, B. J. Goldberg, M. S. Kaplan; Depart- ment of Allergy/Immunology, Kaiser Permanente, Los Angeles, CA.

655 Kaposi's Sarcoma in a Patient with Indeterminant HIV Status and No Other Etiologic Risk Factors A. K. Thethi l, J. A. Shuford 2, Z. Temesgen2; JAllergy and Immunology, Mayo Clinic, Rochester, MN, 21nfectious Diseases, Mayo Clinic, Rochester, MN.

656 Autoimmune Optic Atrophy in a Patient with Common Vari- able Immune Deficiency A. Z. Siedlecki; Allergy & Immunology, Albert Einstein College of Medicine, Bronx, NY.

657 The "Didn't Take Syndrome": Deficiency of a Long-Lasting Antibody Titer After the Pneumovax L. Seido i, R. W. E. Hostoffer, Jr.2; ITods Children's Hospital, Youngstown, OH, 2Case Western Reserve University, Cleveland, OH.

658 Primary Immunodeficiency, Case Report, KF 15 Years' Sur- vival: Is It Evolution or Maturity? L. K. Benarroch I, R. Barroso2; qmmunology, LAGID, Caracas, VENEZUELA, 2Neonatology, LAGID, Caracas, VENEZUELA.

659 Hypogammaglohnlinemia Associated with Herpes Zoster Virus Infection P. V. Zaia, A. M. Castro, A. B. E Fomin, A. C. Pastorino, C. M. A. Jacob; Pediatria, Instituto da Crianca, Sao Paulo, BRAZIL.

660 Natural Killer Cells in Mucocutaneous Candidiasis L. Palma-Carlos; Chiul, Faculty of Medicine, Lisboa, PORTUGAL.

661 Diagnostic of Infection Byhelicobacter pylori (H. p) in Patients with HIV-Positive Effectiveness of Serological Methods vs Ure- asa Test and Biopsy of Mucous Gastric M. E. Flores i, J. Ramos I, M. R. Chac6n 2, A. Pinto 3, M. Pacheco 4, M. R. Chac6n2; IMedicina, CHET, Valencia, VENEZUELA, 2Uni- versidad de Carabobo, Valencia, VENEZUELA, 3Centro Medico "Guerra M6ndez," Valencia, VENEZUELA, 4CHET, Valencia, VENEZUELA.

662 The SCID That Got Away: Transient T-Cell Deficiency in a Vietnamese Adoptee with Pneumocystis Carinii Pneumonia A. J. MacGinnitie, S. E. Turvey, Y. Sasahara, K. Janeway, R. S. Geha, F. A. Bonilla; Division of Immunology, Children's Hospital, Boston, MA.

663 Progressive Decline in Naive T Cells in Clinically Stable Chil- dren with Partial DiGeorge Syndrome C. M. Davis, B. Brown, L. Noroski, W. T. Shearer, H. M. Rosen- blatt; Allergy and Immunology, Baylor College of Medicine, Hous- ton, TX.


664

665

Urticaria 666

Genotype/Phenotype Correlations in CVID S. M. Sheikh I, H. W. Schroeder, III 2, H. W. Schroeder, Jr.3; Ipedi- atrics, University of Alabama at Birmingham, Birmingham, AL, 2Washington & Lee University, Lexington, VA, 3Medicine and Microbiology, University of Alabama at Birmingham, Birming- ham, AL. Safety, Efficacy, Tolerability, and Pharmacokinetics of a New Liquid Intravenous Immuuoglobulin (IVIG) in Comparison to Sandoglobulin| in Patients with Primary Immunodeficiencies (PID) M. Borte 1 , U. Wahn 2, C. Farber 3, E. Bernatowska 4, C. Adams 5, I. Andresen 6, K. Bender6; IUniversity Paediatric Clinic, Leipzig, GERMANY, 2University Paediatric Clinic, Berlin, GERMANY, 3Hospital Erasme, Brussels, BELGIUM, 4The Children's Memori- al Health Institute, Warsaw, POLAND, 5Novartis AG, Basel, SWITZERLAND, 6ZLB Bioplasma AG, Bern, SWITZERLAND.



Desloratadine Suppresses Histamine- and Allergen-Induced Cutaneous Wheal and Flare Responses in Allergic Subjects During 6 Months' Treatment C. Banfield, D. Cutler, L. Shneyer, D. Gates, S. Gupta, R. Sabo, M. Affrime; Schering-Plough Research Institute, Kenilworth, NJ.

667 Mycophenolate Mofetii (MMF) in Chronic Urticaria/Angioede- ma and Idiopathic Anaphylaxis T. M. Lee, A. H. Hirsh; Peachtree Allergy & Asthma Clinic, P.C., and Emory University School of Medicine, Atlanta, GA.

668 A Case of Recalcitrant Autoimmune Urticaria Responding to Intravenous Immunoglobulin (IVIG) Therapy H. N. Subramanian, P. E. Korenblat; Allergy and Immunology, Exotic Washington University, St. Louis, MO. 679

669 Specific IgG4 Levels Predict the Clinical Response to a Fish- Free Diet in Anisakis simplex Sensitized Patients with Chronic Urticaria A. Daschner, E Vega-de-la-Osada; Secci6n de Alergia, Hospital Universitario La Princesa, Madrid, SPAIN.

670 Urticaria and Food Allergy Versus Intestinal Microfiora Over- growth A. A. Nakonechna I, G. N. Drannik j, L. M. Du Buske2; lNational Medical University, Kiev, UKRAINE, 2Immunology Research Institute of New England, Fitchburg, MA. 680

671 Clinical Features and Anaphylaxis in Children with Cold Urticaria A. A. A. Alaugari l, F. J. Twarog 1, M. Shih 2, L. C. Schneiderl; IMedicine/lmmunology, Children's Hospital, Boston, MA. 2Bio- statistics, Children's Hospital, Boston, MA.

672 Treatment of Severe Cold Urticaria with Associated Cetirizine and Zafirlukast E Bonadonna j, C. Lombardi 2, G. Senna 1, G. W. Canonica 3, G. 681 Passalacqua3; I Allergy Service, Allergy Unit Verona General Hos- pital, Verona, ITALY, 2Allergy & Respiratory Unit, Department of Internal Medicine, S. Orsola Fatebenefratelli Hospital Brescia, Brescia, ITALY, 3Department of Internal Medicine, Genoa Univer- sity Allergy & Resp. Diseases, Genova, ITALY.

673 Papular Urticaria and Atopy: What Relationship? C. Santa-Marta, M. Neto, E. Pargana, M. Morais-AImeida, J. Rosado-Pinto; lmmunoallergy Department, D. Estef~nia Hospital, Lisbon, PORTUGAL. 682

674 Chronic Urticaria and Helicobacter Pylori Positive Gastritis V. Djuric, M. Bogic; Institute of Allergology and Immunology, Belgrade, YUGOSLAVIA.

Poster Session 45o5


Ocular Allergy 675 An Environmental Study of Ophthalmic Epinastine in Patients

with Allergic Conjunctivitis M. A. Abelson I , P. Ghosh 2, R. Bradford 3, B. Kim 3, R. Schiffman 3, S. Whitcup3; IOphthalmology Department, Schepens Eye Research Institute, Boston, MA, 2Medical Affairs R&D, Allergan Ltd, High Wycombe, UNITED KINGDOM, 3Ophthalmology Clin- ical Research, Allergan, Inc, Irvine, CA.

676 Pharmacokinetic and Safety Profile of Epinastine After Ocular Administration in Patients with Allergic Conjunctivitis D. Yu 1, P. Ghosh 2. D. Tang-Liu3; IPharmacokinetics Department, Allergan Inc, lrvine, CA, 2Advisor of Medical Ophthalmology, Allergan Ltd, Wycombe, UNITED KINGDOM, 3Pharmacokinet- ics Department, Allergan Inc. Invine, CA.

677 The Efficacy of Immunotherapy (IT) in Treatment of Allergic Conjunctivitis (AC): A Meta-Analysis A. Mongia t, L. Bielory2; IDivison of Allergy & Immunology, Department of Medicine, UMDNJ NJ Medical School, Newark, N J, 2Department of Medicine, UMDNJ NJ Medical School, Newark, NJ.

678 Allergic-Like Ocular Symptoms in Menopausal Women J. Du I, G. B. Zuckerman 2, L. Bielory2; tDivision of Allergy & Immunology, Department of Medicine, UMDNJ NJ Medical School, Newark, N J, 2UMDNJ NJ Medical School, Newark, NJ.

Poster Session 4506


and Unusual Sources of Allergen Exposure Skin Sensitivity to Aspergillus flavus in Patients with Soybean Induced Asthma and/or Allergic Rhinitis L. R. F. Ardusso t, R. Codina 2, C. D. Crisci l, R. E Lockley 2, J. Molinas 1. I. Medina l, S. Trobbiani l, C. L6pez 3, L. Ramos3; I Department of Allergy and Immunology, Rosario School of Med- icine, Rosario, ARGENTINA, 2Division of Allergy and Immunol- ogy, Department of Internal Medicine, University of South Florida, College of Medicine and James A. Haley VA Hospital, Tampa, FL, 3Mycology Reference Center (CEREMIC), University of Rosario, Rosario, ARGENTINA. IPEADAM Study: Difference in Housing Characteristic and Exposure to Indoor Pollutants in Asthmatic Children and Healthy Controls G. Tavernier I, G. Fletcher I , G. Blacklock 2, T. Frank I , P. Frank l, A. C. Pickering t, R. M. L. NivenJ; INorth West Lung Research Centre, Wythenshawe Hospital, Manchester, UNITED KING- DOM, 2Aric, Manchester Metropolitan University, Manchester. UNITED KINGDOM. Pollen Aeroallergen Sensitization in Children with Seasonal Allergic Rhinitis C. Baena-Cagnani t , A. Finn 2, P. Potter 3 , R. Menendez 4, G. Olsen 5 , E. Ruutht; 1Department of Pediatrics, Infantile Hospital Cordoba, Cordoba. ARGENTINA, 2Radiant Research, Charleston, SC, 3Allergology and Diagnostic Research Unit, Lung Institute, Cape Town, SOUTH AFRICA, 4Allergy and Asthma Research Centre of E1 Paso, El Paso, TX, 5Clinical Research Centers of Colorado, Wheat Ridge, CO, 6Aventis Pharma, Romainville Cedex, FRANCE. Hammocks as Important Sources of Exposure to Mite Allergen in Northeast Brazil E X. M. Rego ~ , M. T. Barros l, G. Matos 2, J. Kalil I, P E C. Bruim 2, K. R. C. Tobias 3, M. D. Chapman 4. L. K. Arruda-~; IUniversity of


Sao Paulo, Sao Paulo, BRAZIL, 2Federal University of Cear~i, For- taleza, BRAZIL, 3University of S~o Paulo, Ribeir~o Preto, BRAZIL, 41ndoor Biotechnologies Inc, Charlottesville, VA.

683 Characterization of Potential Human Exposure to Fragrances During Consumer Product Use R. E. Rogers t, D. A. Isola 2, L. W. Smith3; IToxcon Health Sci- ences Research Centre Inc, Edmonton, AB, CANADA, 2Resarch Institute for Fragrance Materials, Inc, Hackensack, NJ, 3Research Institute for Fragrance Materials, Inc, Hackensack, NJ.

684 Fungal Contamination and Fungal Diversity on New Acoustic Ceiling Tiles A. Govert, E. Levetin; Biological Science, University of Tulsa, Tulsa, OK.

685 Occurrence and Distribution of Mold in the Home Environment K. A. Reynolds t, S. Boone 2, C. P. Gerba2; tEnvironmental Sci- ence, The University of Arizona, Tucson, AZ, 2Microbiology, The University of Arizona, Tucson, AZ.

688 An Emerging Cause of Allergic Asthma: The Jerboa Pet J. C. Sainz Gutlerrez I , G. Minguez I, J. M. Beitia I , C. de Frutos I , M. de las Heras 2, M. de BarrioJ, T. Herrero l, P. Tornero 1, J. M. Zubel- dia l, M. L. Baeza t, L. Zapateroi; IAllergy, H. G. U. Gregorio Mara- non, Madrid, SPAIN, 2Allergy, E Jimenez Diaz, Madrid, SPAIN.

887 Mite Sensitization: Trends in the Past 4 Years S. Cadinha, D. Malheiro, J. Fonseca, A. Coimbra, J. P. M. Silva, M. Vaz; Unidade de lmunoalergologia, Hospital S. Ioao, Porto, PORTUGAL.

888 Rhinitis and Asthma Induced by "Christmas Flower" (Euphor- bia Pulcherrima) M. Ibafiez-Sandin l, M. Fern~indez-Nieto 2, J. Martinez 3, S. Quirce 2, J. Sastre2; t Allergy, Hospital Niflo Jesus, Madrid, SPAIN, 2Allergy, Fundacion Jimenez Diaz, Madrid, SPAIN, 3pharmacia Diagnostics, Barcelona, SPAIN.

689 Comparison of the Rotorod Sampler to Three Other Methods for the Determination of Ambrosia artemisiifolia Pollen Con- centrations in the Environmental Exposure Unit M. J. Heifer l, J. D. Ratz I , J. D. Miller 2, J. H. Day1; 1Division of Allergy & Immunology, Kingston General Hospital, Kingston, ON, CANADA, 2Ottawa-Carleton Institute of Chemistry, Carleton University, Ottawa, ON, CANADA.

890 An Evaluation of the "Toxic Mold Syndrome" D. A. Edmondson, M. E. Nordness, M. C. Zacharisen, J. N. Fink; Allergy and Immunology, Medical College of Wisconsin, Milwau- kee, WI.

1591 Exposure and Sensitization to Airborne Fungi in an Office Environment C. Dinakar 1, F. Pacheco 2, F. Hu 2, C. Barnes 2, J. Portnoy2; IAller- gy/Asthma/lmmunology, Children's Mercy Hospital, Kansas City, MO, 2Children's Mercy Hospital, Kansas City, MO.

1592 Airborne Fungal Colony-Forming Units (CFU) in Indoor Envi- ronments in Seoul, Korea G. C. Jang, C. H. Kim, W. K. Kim, M. H. Sohn, K. E. Kim; Dept. of Pediatrics, Severance Hosp., Seoul, REPUBLIC OF KOREA.

693 Contamination of Flour Samples with German Cockroach, Mouse, and Rat Antigens L. L. Mobley; University of South Florida, Tampa, FL.

Poster Session 45o7


What's New in Allergen Detection and Standardization? 694 Polyclonal and Monoclonal Antibodies to Cloned and Native

AIt al H. M. Vijay, V. Kumar, M. Abebe, S. Sevincz'Environmental Health, Health Canada, Ottawa, ON, CANADA.

695 Monitoring Exposure to Bla g 5 Cockroach Allergen J. C. GorO, A. Tsay 2, C. Schal 1, M. D. Chapman 2, A. Pomes2; 1Department of Entomology, North Carolina State University, Raleigh, NC, 21NDOOR Biotechnologies, Inc, Charlottesville, VA.

696 Determination of Major Allergen Protein, Ole e 1, in Aqeuous and Glycerinated Allergenic Extracts G. Plunkett I, W. Caples 1, K. Poppe2; IALK-Abello, lnc, Round Rock, TX, 2ALK-AbelIo, lnc, Round Rock, TX.

691 Profiling of Crude Allergen Extracts Using SELDI Mass Spec- trometry for Rapid Standardization K. Reginald, X. Z. Bi, S. T. Ong, E T. Chew; National University of Singapore, Singapore, SINGAPORE.

698 A Diagnostically Relevant Epitope of A. fumigatus I'. U. Sarma I, T. M. Gupta 1, P. Priyadarsiny i , A. Shah 2, W. Haq 3, S. B. Katti3; 1Molecular Biochemistry and Diagnostics, Centre for Biochemical Technology, Delhi, INDIA, 2Clinical Research Cen- tre, Vallabh Bhai Patel Chest Institute, Delhi, INDIA. 3Biopolymer Division, Central Drug Research Institute, Lucknow, INDIA.

699 Endotoxin in Standardized Allergen Vaccines J. E. Slater, C. Valerio, B. Trivedi', Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD.

700 Mediator Release Assays Based on Human or Mnrine IgE in Allergen Standardization S. Kaul, A. Hoffmann, D. L[ittkopf, B. Kastner, G. Hrltz, S. Vieths; Department of Allergology, PauI-Ehrlich-lnstitut, Langen, GERMANY.

701 Comparison of Monoclonal and Polyclonal Antibody Assays for Allergen Detection in House Dust J. A. Berustein i , J. Parks 2, M. Wanner t , R. Floyd 1, B. Williams 2, D. I. Bernsteinl; qnternal Medicine/Division of Immunology/ Allergy Section, University of Cincinnati College of Medicine, Cincinnati, OH, 2HealthyHomeAir, Cincinnati, OH.

702 Physicochemical and Immunological Comparison between Natural and Recombinant Pro p 3: Potential Applications M. Lombardero I, A. Diaz-Perales 2, M. L. Sanz 3, G. Garcfa-Casa- do 2, R. S~inchez-Monge 2, E J. Garcfa-Sellrs 4, F. Polo 1, P. Gain- boa 5, D. Barber I, G. Salcedo2; IALK-Abellr, S.A., Madrid, SPAIN, 2E.T.S. lngenieros Agr6nomos, Madrid, SPAIN, 3Clfnica Universitaria de Navarra, Pamplona, SPAIN. 4Hospital Virgen de la Arrixaca, Murcia, SPAIN, 5Hospital de Basurto, Bilbao, SPAIN.

703 Using a Short Allergen Skin Test Panel to Screen for Atopy in San Francisco Bay Area A. Xu, A. T, Tevrizian, G. Mote-Yates, J. L. Kishiyama, P. C. Avila: Internal Medicine, Division of Allergy, Asthma and Immunology, UC San Francisco Medical Center, San Francisco, CA.

704 Peptidase Activity and Inhibition Profile of House Dust Com- pared to an International House Dust Mite Extract Standard P. Meighan, J. Baker, R. Pirzad, T. Cooke; Acaris Ltd, Cambridge, UNITED KINGDOM.

705 The Stability of Major Allergens in Mite and Grass Allergenic Extracts W. Caples l, G. Plunkett2; IALK-Abello, lnc, Round Rock, TX, 2ALK-Abello, lnc, Round Rock, TX.

706 Validation of a Competitive ELISA for the Detection of Anti- gens from German Cockroaches (CR) C. Reynolds I, E. Horowitz i, T. Green I, R. J. Brenner 2, M. C. Anderson 3, D. Milne 4, A. Togiast; Uohns Hopkins University, Bal- timore, MD, 2USDA-ARS, Washington, DC, DC, 3FDA, Washing- ton, DC, DC, 4USDA-ARS, Gainesville, FL.

707 Comparison of Mite Extracting Techniques Using Two-dimen- sional Electrophoresis S. Jinlu I , Z. Hongyu i , Y. Wantao 2, Q. Xiaohong 2, Y. Jia I , W. Lian- glu I, W. Ruiqil; 1Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, CHINA, 2proteinmics Center. Beijing Radiation Institute. Beijing, CHINA.


"/fib Checkmite---An Eco-friendly Aerosol Spray for the Control of House Dust Mites P, V. Subbarao 1, R. S. Annadurai 2, M. Srinivas2; IVittal Mallya Scientific Research Foundation, Bangalore, INDIA, evittal Mallya Scientific Research Foundation, Bangalore, INDIA.

7'09 Comparative Incidence of Skin Reactivity to D. pteronyssinus (DP) and D. farinae (DF) in the San Francisco Bay Area D. F. German I, F. R. Bocobo ], J. M. Roberto e, M. B. Strubl; I Kaiser Permanente Medical Center, San Francisco, CA, eKAiser Permanente Medical Center, San Francisco, CA.

710 Detection of Multicolored Asian Lady Beetle Harmonia axyridis Allergens in their Blood E. M. Magnan ], H, Sanchez 2, R. K. Bush3; IAllergy/Immunology, University of Wisconsin-Madison, Madison, WI, 2Research, VA- Hospital, Madison, WI, 3Department of Medicine, University of Wisconsin-Madison, Madison, WI.

711 The Comparative Incidence of Skin Test Reactivity to Ambrosia psilotachya (Western Ragweed) and Artemisia douglasiana (Douglas' Mugwort) in the San Fransisco Bay Area F. R. Bocobo, D. E German, J. M. Roberto, M. B. Strub; Kaiser Permanente Medical Center, San Francisco, CA.

712 The Production of Monoclonal Antibodies Against the Toxi- genic Fungus Stachybotrys chartarum D. Schmechel, J. P. Simpson, D. M. Lewis; Health Effects Labo- ratory Division, CDC/Natl. Inst. Occup. Safety & Health, Morgan- town, WV.

Poster Session 45o8


Food Hypersensitivity." Allergens 713 Binding of IgE from Peanut Allergic Sera to the Major Peanut

Allergens, Ara h 1 and Ara h 2: Comparison of IgE Immunoblots to a Functional Assay G. W. Palmer l, D. A. Dibbern, Jr3, A. W. Burks 3, G. A. Bannon 4, S. A. Bock 5, S. C. Dreskin6; i private practice, Mystic, CT, 2private practice, Portland, OR, 3University of Arkansas, Little Rock, AR, 4Monsanto, Chesterfield, MO, 5private practice, Boulder, CO, 6Medicine, Allergy/Immunology, Univ. Col. Health Science Cen- ter, Denver, CO.

714 The Effect of Roasting on Solubility and Allergenicity of Peanut Protein Allergens J. Odum 1,2, R. A. Kopper 1,2, M. Sen L2, J. Stanley 1,2, R, M. Helm ],2, A. W. Burksi,2; tPediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children's Hospital, Little Rock, AR.

715 Purification of Peanut Allergen Ara h 2 for Crystallization L. PonsL2, R. M. Helm 1.2, J. S. Stanley 1,2, G. A. Bannon 3, H. A. Sampson 4, A. W. Burksl,2; IPediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children's Hospital, Little Rock, AR, 3Monsanto, St. Louis, MO, 4Mt. Sinai School of Medicine, New York, NY.

716 Murine IgE and IgG Antibody Responses to Peanuts and Shrimp Allergens: Major Food Allergens in Man S. B. Lehrer j, J. Fernandes 2, R. Reisch 2, P. Gaudry l, G. Dai 1, G. Reese3; IMedicine-Clinical Immunology, Tulane University Health Sciences Center, New Orleans, LA, 2Department of Biolo- gy, Paul Tulane College, New Orleans, LA, 3Allergology, Paul- Ehrlich-lnstitut, Langen, GERMANY.

717 Effect of Enzyme Treatment on the Allergenic Properties of Peanuts S. Chung, E. T. Champagne; USDA, SRRC, New Orleans, LA.

71fi Screening Mutant Peanuts for Allergen Knockouts D. A. Schmitt 1, S. J. Maleki j, T. G, Isleib e, E. T. Champagne3; 1Allergy, USDA-ARS, New Orleans, LA, ~Crop Science, North

Carolina State University, Raleigh, NC, 3USDA-ARS, New Orleans, LA.

719 Gastric Digestion of Peanut Protein Allergens is Carried out Rapidly and Almost Exclusively by Pepsin R. A. Kopper 1.2, J. Odum 1,2, M. Sen L2, J. S. StanleyL2, R. M. Helm 1.2, A. W. Burksl.2; ]Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children's Hospital, Little Rock, AR.

720 Identification and Cloning of Jug r 4, a Major Food Allergen from English Walnut Belonging to the Legumin Group S. S. Teuber l, W. R. Peterson ], S. Uratsu 1, A. Dandekar ], K. H. Roux 2, S. K. SatheZ; IUniversity of California, Davis, CA, 2Flori- da State University, Tallahassee. FL.

721 Validated ELISA for Detection of Undeclared Walnut Residues in Food L. Niemann, S. L. Hefle: Food Allergy Research and Resource Program, University of Nebraska, Lincoln, NE.

722 Cloning, Identification, and Epitope-Mapping Two Black Wal- nut (Juglans Niger) Allergens M. Ling 1,2, J. Ye 3, K. Beyer 4, G. Cockrell i,z, G. A. Bannon -s, J. S. Stanley 12, R. M. Helm 1,2, H. A. Sampson 4, A. W, Burksl,2; 1Pedi- atrics, University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children's Hospital, Little Rock, AR, 3Anatomy, Univer- sity of Arkansas for Medical Sciences, Little Rock, AR, 4Mt. Sinai School of Medicine, New York, NY, 5Monsanto, St. Louis, MO.

723 Recombinant Hazelnut LTP, Cor a 8: A Useful Tool in the in vitro Diagnosis of Hazelnut Allergy E Schocker j , D. Ltittkopf 2, A. Cister6-Bahfma 3, E. Enrique 3, J. H. Akkerdaas 4, R. van Ree 4, S. Vieths 2, W. M. Becker]; IBiochemical and Molecular Allergology, Research Center Borstel, Borstel, GERMANY, 2Paul-Ehrlich-lnstitut, Langen, GERMANY, 3lnstitut Universitari Dexeus, Barcelona, SPAIN, 4CLB, Sanquin, Amster- dam, NETHERLANDS.

724 Identification of a Heat Shock Protein as a Major Hazelnut Food Allergen in Hazelnut Induced Systemic Reactions K. Beyer, L. Bardina, G. Grishina, A. Grishin, H. A. Sampson; Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY.

725 Ana o 2, a Major Cashew Nut Allergen of the Legumin Family J. M. Robotham 1, E Wang t, S. S. Teuber 2, S. K. Sathe 3, K. H. Roux]; I Biological Science, Florida State University, Tallahassee, FL, 2Division of Rheumatology, Allergy & Clinical Immunology, University of California, Davis, School of Medicine, Davis, CA, 3Department of Nutrition, Food & Exercise Sciences, Florida State University, Tallahassee, FL.

"/26 IgE from the Serum of a Cashew-Allergic Patient Identifies a Cashew Nut Antigen with a Molecular Weight of Less Than 14.4 kDa P. Makornwattana, G. Avshalomov, V. R. Bonagura; Allergy & Immunology, Long Island Jewish Medical Center, New Hyde Park, NY.

727 Changes of Allergenecity of Salted and Fermented Shrimp C. Hong I, S. Bae 2, S. Choi 2, H, Jin 2, C. Kim3; IDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 2yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 31nha University, Inchon, REPUBLIC OF KOREA.

728 Linseed Hypersensitivity: Characterization of Allergens M. Rodriguez-Rodriguez I. E Leon 2, M. Cuevas2; JAllergology, Hospital Principe Asturias, Madrid, SPAIN, 2Hospital Ramon y Cajal, Madrid, SPAIN.

729 Lettuce Anaphylaxis: Identification and Characterization of a Lipid Transfer Protein as the Major Allergen M. San Miguel-Moncin 1, A. Cistero-Bahima 1, M. Krail 2, S. Scheurer 2, E. Enrique 1, R. Alonso 1, A. Conti 3, S. Viethse: 1Allergy Department, lnstitut Universitari Dexeus, Barcelona, SPAIN,

S390 A b s t r a c t s J ALLERGY CLIN IMMUNOL

FEBRUARY 2003

2paul-Ehrlich-lnstitut, Langen, GERMANY, 3Consiglio Nazionale delle Ricerche (CNR)-Institute of Science of Food Procuction, Collereto Giacosa, Turin, ITALY.

730 Development of an in vitro Model to Reduce Allergenicity of Sweet Cherry (Prunus avium L.) by RNA Interference (RNAi) A. Reuter l, A. Matt 2, S. Scheurer 1, J. Jehle 3, S. Viethsl; IAllergol- ogy, Paul-Ehrlich-Institute, Langen, GERMANY, 2Biotechnologi- cal Crop Protection, Staatlich Lehr- und Forschungsanstalt fiJr Landwirtschaft, Weinbau und Gartenbau, Neustadt an der Wein- stral3e, GERMANY, 3Biotechnological Crop Protection, Staatliche Lehr- und Forschungsanstalt f/.ir Landwirtschaft, Weinbau und Gartenbau, Neustadt an der WeinstrafSe, GERMANY.

731 Influence of Heating and Digestion on the B-cell Epitopes of Cow's Milk Allergens Y, Morisawa I, K. Matsumoto 2, A. Akasawa 2, H. Saito 2, H. Wakiguchil; IPediatrics, Kochi Medical School, Kochi, JAPAN, 2Allergy, National Research Institute for Child Health and Devel- opment, Tokyo, JAPAN.

732 Evaluation of Allergenicity in Dairy Products by SDS-PAGE H. Park l, Y. Park 2, K. Ahn 3, S. Lee3; IPediatrics, Sam-Sung Med- ical Center, Seoul, REPUBLIC OF KOREA, 2Eulji University School of Medicine, Seoul, REPUBLIC OF KOREA, 3Sam-Sung Medical Center, Seoul, REPUBLIC OF KOREA.

733 In Vitro Characterization of the Allergenicity and Protein Pro- files of Two Kiwi Fruit Varieties S. A. Lewis 1, A. PearcO, J. Lucas 2, J. O. Hourihanet; qnfection, Inflammation and Repair Division, University of Southampton, Southampton, UNITED KINGDOM, 2Child Health, Southampton University Hospital NHS Trust, Southampton, UNITED KINGDOM.

734 Determination of Allergenicity of Different Food Allergens in a Rat Model of Food Allergy B. Ahrens 1, D. Quarcoo j, A. Meeuw 1, J. Zagon 2, G. Reese 3, S. Vieths 3, E. Hamelmannl; IDepartment of Pediatric Pneumology and Immunology, CharitE-Humboldt University, Berlin, GER- MANY, 2Federal Institute for Health Protection of Consumers and Veterinary Medicine, BgVV, Berlin, GERMANY, 3Department of Allergology, Paul-Ehrlich Institute, Langen, GERMANY.

Poster Session 4509


Food Hypersensitivity: Epidemiology, Diagnosis, and Treatment 735 Effect of Suplatast Tosilate, a Th2 Cytokine Inhibitor, on

Murine Food Allergy Model on the Small Intestine and Liver Damages Y. I ikura, S. Yofu, T. Takahashi, K. Ueno; Showa University School of Medicine, Tokyo, JAPAN.

736 Cashew Nut Allergy in Children E RancE I, E. Bidat 2, T. Bourrier 3, D. Sabouraud4; IHEpital des Enfants, Toulouse, FRANCE, 2Service de PEdiatrie, HEpital Ambroise ParE, FRANCE, 3Service de PEdiatrie, CHU Nice, FRANCE, 4Service de PEdiatrie, CHU Reims, FRANCE.

737 The Natural History of Milk Allergy S. H. Joo I, M. K. Conover-Walker 2, R. A. Wood2; IAllergy and Immunology, Johns Hopkins University, Baltimore, MD, 2Allergy and Immunology, Johns Hopkins Univeristy, Baltimore, MD.

738 Population-Based Survey of Eczema and Food Allergy During Infancy in Japan I. Prevalence of Infantile Eczema at the Age of 4 Months M. Ebisawa, C. Sugizaki, K. lkematsu, H. Tachimoto; Pediatric Allergy, National Sagamihara Hospital, Sagamihara, JAPAN.

739 Food Allergy in Inner-City Children with Asthma M. Mishoe, L. E C. Shek, K. Beyer, H. A. Sampson; Pediatrics, Mount Sinai School of Medicine, New York, NY.

740 Determination of Food-specific IgE Levels Over Time Can Be Used to Predict the Development of Tolerance in Cow's Milk and Hen's Egg Allergy L. P. C. Shek, K. Beyer, M. Mishoe, H. A. Sampson; Pediatrics, Mount Sinai School of Medicine, New York, NY.

741 The Relationship of Allergen-Specific IgE Levels to the Out- come of Oral Food Challenges M. Conover-Walker, R. A. Wood; Pediatrics, Johns Hopkins Uni- versity, Baltimore, MD.

742 Prediction of Buckwheat Allergy Using Specific IgE Concen- trations in Children K. Kim I , M. Sohn 2, S. Lee3; IPediatrics, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 2yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 3Ajou Uni- versity School of Medicine, Suwon, REPUBLIC OF KOREA.

743 The Pattern of Sesame Sensitivity Among Infants and Children I. Dalai I, I. B inson 2, A. Ballin 3, E. Somekh4; 1Allergy/Immunolo- gy Unit, Department of Pediatric, E. Wolfson Medical Center, Holon, ISRAEL, 2E. Wolfson Medical Center, Holon, ISRAEL, 3E. Wolfson Medical Center, Holon, ISRAEL, 4E. Wolfson Medical Center, Holon, ISRAEL.

744 Sesame Allergy: Natural History and Long-Term Follow-up A. Cohen I, B. Levy 2, Y. Katz3; 1Allergy Immunology Inst., Assaf Harofeh Medical Center, Zerifin, ISRAEL, 2Assaf Harofeh Med- ical Center, Allergy/Immunology Inst., ISRAEL, 3Assaf-Harofeh Medical Center, Zerifin, ISRAEL.

745 Spectrum of Skin Test Reactivities to Shellfish in Allergic Patients A. Y. Y. Wu; Medicine, University of Hong Kong, Pokfulam, HONG KONG SPECIAL ADMINISTRATIVE REGION OF CHINA.

746 A Survey on the Management of Oral Allergy Syndrome (OAS) in Allergy Practices S. Ma I, S. H. Sicherer 2, H. A. Sampson 2, A. Nowak-Wegrzyn2; tDivision of Clinical Immunology, Mount Sinai Medical Center, New York, NY, 2Division of Pediatric Allergy and Immunology, Mount Sinai Medical Center, New York, NY.

747 Complementary and Alternative Medicine (CAM) in Food Allergy: A Survey J. I. Lee j, X. Li I, T. J. Furlong 2, S. H. SichererJ; 1Pediatrics, Mount Sinai School of Medicine, New York, NY, 2Food Allergy and Anaphylaxis Network, Fairfax, VA.

748 Prevalence of Soy Protein Hypersensitivity in Korean Children Sensitized to Cow Milk Protein K. Ahn 1, S. Nam 2, Y. Han I, S. Leel; t Pediatrics, Samsung Medical Center, Seoul, REPUBLIC OF KOREA, 2pediatrics, Ilsan Baik Hospital, Ilsan, REPUBLIC OF KOREA.

749 Validation of a Basophil Activation Test (BAT) for the Diagno- sis of Birch Pollen Associated Apple-Mediated Oral Allergy Syndrome (OAS) D. G. Ebo, C. Toelen, S. Van Tongelen, A. J. Schuerwegh, C. H. Bridts, L. S. De Clerck, W. J. Stevens; lmmunology-Allergology- Rheumatology, University of Antwerp, Antwerpen, BELGIUM.

750 Moderate Doses of Oral Histamine Can Provoke Symptoms in Healthy Volunteers S. Wiihrl t2, W. Hemmer 2, M. Focke 2, K. Rappersberger 3, R. Jarisch2; IDly of Immunology, Allergy and Infectious Diseases (DIAID), Dept of Dermatology, University of Vienna Medical School (AKH Wien), Vienna, AUSTRIA, 2Floridsdorf Allergy Centre (FAZ), Vienna, AUSTRIA, 3Dept of Dermatology, KA Rudolfstifiung, Vienna, AUSTRIA.

751 Avian Meat Anaphylaxis: Double-Blind, Placebo-Controlled, Oral Challenge Study C. Escudero 1, J. Cuesta I, B. Bartolom62, J. de Miguel l, E. Com- pEs 1, M. de las Heras j, S. QuircO; 1Allergy Department, Fun- daci6n JimEnez Dfaz, Madrid, SPAIN, 2Bial-Arfstegui Laborato- ries, Bilbao, SPAIN.


752 Allergy to Anisakis simplex in the Portuguese Population C. Nunes, S. Ladeira; Center of Allergy and Immunology of Algarve, Portimao, PORTUGAL.

753 Advair Prevents Alcohol-Induced Asthma A. E. Varner; Allergy Diagnostic, Beachwood, OH.

Poster Session 4510


Epidemiology and Risk Factors in Atopic Disorders 754 Associations between Sensitization to Different Allergens in

Childhood G. Roberts I, C. Peckitt 2, D. Strachan 3, G. Lack 4, J. GoldingS; IPaediatric Allergy, Asthma and Immunology, Imperial College at St. Mary's, London, UNITED KINGDOM, 2Department of Public Health Sciences, Georges's Hospital Medical School, London, UNITED KINGDOM, 3Department of Public Health Sciences, St. Georges's Hospital Medical School, London, UNITED KING- DOM, 4pediatric Allergy, Asthma and Immunology, Imperial Col- lege at St. Mary's, London, UNITED KINGDOM, 5Unit of Paedi- atric and Perinatal Epidemiology, University of Bristol, London, UNITED KINGDOM.

755 Factors Associated with the Development of Asthma and Aller- gic Diseases among Resident Singapore Schoolchildren: Increased Risk Among Singapore-Born Compared to Non-Sin- gapore-Born Children X. S. Wang, T. N. Tan, L. P. C. Shek, D. Y. T. Goh, B. W. Lee, F. T. Chew; National University of Singapore, Singapore, SINGAPORE.

756 Asthma Hospital Discharge Rates in Delaware for Children Aged 0-17 years, 1994-2000 A. Lateef I, R. A. Ruggiero 2, C. A. Morales-Mateluna 3, S. Dow- shen 4, E. Yousef 5, S. J. McGeadyS; IAllergy and Immunology, A. I. duPont Hospital for Children and Thomas Jefferson University, Wilmington, DE, 2Delaware Department of Health, Dover, DE, 3Thomas Jefferson University, Philadelphia, PA, 4A. I. duPont Hospital for Children, Wilmington, DE, 5A. I. duPont Hospital for Children and Thomas Jefferson University, Wilmington, DE.

757 Incidence of Events Consistent with Hypersensitivity Reactions to Penicillin in a Large Electronic Medical Record Database A. J. Apter I , J. Kinman 2, W. B. Bilker 2, M. Herlim 2, A. Sallen 3, B. L. Strom2; IMedicine and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, 2Univer- sity of Pennsylvania, Philadelphia, PA, 3Center for Clinical Epidemi- ology and Biostatistics, University of Pennsylvania, Philadelphia, PA.

758 Prevalence and Economic Burden of Rhinitis in Patients Treat- ed for Asthma C. Leibman I, L. O'Dowd I, C. Roberts 2, T. McLaughlin3; IAstraZeneca LP, Wilmington, DE, 2NDCHealth, Yardley, PA, 3NDCHealth, Phoenix, AZ.

Poster Session 4511

M o n d a y , M a r c h 10 10:45 A M to 11:45 A M

Eosinophils 759 Reciprocal Production of M-CSF and GM-CSF by Human

Eosinophils after Stimulation with Secretory IgA and LPS M. Terakawa 1,2, K. Matsumoto 2, S. Fukuda 2, H. Saito2; ISuntory Biomedical Research Ltd, Osaka, JAPAN, 2National Research Institute for Child Health & Development, Tokyo, JAPAN.

760 Actin Assembly is a Crucial Role on Effector Functions of Adherent Human Eosinophils M. Kato j , M. Suzuki I, A. Tachibana I , T. Takizawa I , H. Arakawa I , H. Mochizuki j , K. Tokuyama I , H. Kimura 2, H. Hanaka 3, T. Izumi 3,

A. Morikawal; I Pediatrics, Gunma University School of Medicine, Maebashi, JAPAN, 2Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, JAPAN, 3Biochemistry, Gunma University School of Medicine, Maebashi, JAPAN.

761 Heparanase is Contained in Human Peripheral Blood Eosinophils and its Activity is Inhibited by Eosinophil Granule Basic Proteins V. Temkin 1 , H. Aingorn 2, O. Goldshmidt 2, G. Gleich 3 , I. Vlodavsky 2, E Levi-SchafferJ; 1Pharmacology, School of Pharmacy, Hebrew Uni- versity of Jerusalem, Jerusalem, ISRAEL, 2Oncology, Hadassah Medical School, Hebrew University of Jerusalem, Jerusalem, ISRAEL, 3Dermatology, School of Medicine, Salt Lake City, UT.

762 Novel Calcium-Dependent Pathways in EosinophU Interaction with Secretory Product(s) of the Fungus Alternaria Y. Inoue, S. H. Shin, J. U. Ponicau, H. Kita; Mayo Clinic, Rochester, MN.

763 Severe Peripheral Blood EosinophUia: A Frequently Neglected Finding in Hospitalized Patients T. Voltsinger t, E. M. Eisenstein 2. Y. Berkun 3, M. Shali0 ; IAllergy and Clinical Immunology Unit, Hebrew University-Hadassah Medical Center, Jerusalem, ISRAEL, 2Department of Pediatrics, Hebrew University-Hadassah Medical Center, Jerusalem, ISRAEL, 3Department of Pediatrics, Bikur Holim Hospital, Jerusalem, ISRAEL.

764 2B4 (CD244) is Expressed and Functional on Human Periph- eral Blood Eosinophiis A. Munitz t, M. Colonna 2, E Levi-Schaffer3; IDepartment of Phar- macology, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, ISRAEL, 2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 3Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, ISRAEL.

765 Surface Expression of Eosinophil Major Basic Protein (MBP) and Eosinophil Peroxidase (EPO), Without Apparent Extracel- lular Release, by Activated Human Eosinophils T. Matsuura, K. R. Bartemes, D. L. Squillace, G. J. Gleich, H. Kita; Immunology, Mayo Clinic, Rochester, Rochester, MN.

766 Role of Caspases and Mitochondria in Siglec-8-Mediated Eosinophil Apoptosis E. Nutku, S, Hudson, B. S. Bochner; Medicine, Johns Hopkins University, Baltimore, MD.

767 Functional Analysis of the Chemokine Receptor CCR3 on Purified Human Eosinophils J. W. Loveless, M. E. Brummet, B. S. Dailey, T. E. Nutku, C. Stclla- to, L. A. Beck; Medicine, Johns Hopkins University, Baltimore, MD.

768 Roles of Extracellular Matrix Proteins in Eosinophil Chemo- taxis Y. Kato j, T. Fujisawa 2, H. Nishimori 3, H. Katsumata 2, J. Atsuta 2, K. Iguchi 2, H. Kamiya 2, T. Nakayama 4, O. Yoshie4; IClinical Research, National Mie Hospital, Tsu, JAPAN, 2pediatrics and Allergy, National Mie Hospital, Tsu, JAPAN, 3pediatrics, Suzuka Kaisei General Hospital, Suzuka, JAPAN, 4Microbiology, Kinki University, Osaka, JAPAN.

769 Histamine Induces Eosinophil Chemotaxis, Possibly Through H4 Receptors T. Fujisawa I, Y. Kato z, H. Katsumata j, J. Atsuta I, K. Iguchi i, H. Kamiya I, T. Nakayama 3, O. Yoshie3; IPediatrics and Allergy, National Mie Hospital, Tsu. JAPAN, 2Clinical Research, National Mie Hospital, Tsu, Mie, JAPAN, 3Microbiology, Kinki University, Osaka, JAPAN.

770 Myosin Light Chain Kinase Mediates Eosinophil Chemotaxis in a Mitogen-Activated Protein Kinase-Dependent Manner T. Adachi I, S. Stafford 2, J. Chihara I, R. Alam2; IDepartment of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, JAPAN, 2Division of Allergy and Immunology, The University of Texas Medical Branch, Galveston, TX.

$ 3 9 2 Abs t rac ts J ALLERGY CLIN IMMUNOL FEBRUARY 2003

771 Involvement of 5-Lipoxygenase (5-LO) Pathway in Eosinophils Chemotaxis to Acetylsalicylic Acid (ASA) P. Kuna, M. M. Kurowski, 1. Kuprys, B. Kuzminska, P. Gorski; Pneumonology and Allergy, Medical University of Lodz, Lodz, POLAND.

772 The Mouse Eosinophil Secondary Granule Proteome: Strate- gies, Methods, and Analyses Leading to the Identification of Specific Granule Constituents M. P. McGarry ], K. M. Dobos ], R. Nunez 2, B. S. Scott 2, R. Rooney 2, N. A. Lee 3, J. J. Leel; IDepartment of Biochemistry and Molecular Biology, Division of Pulmonary Medicine, Mayo Clin- ic Scottsdale, Scottsdale, AZ, 2Invitrogen, Carlsbad, CA, 3Depart- ment of Biochemistry and Molecular Biology, Division of Hema- tology/Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ.

773 LTD 4 Induces Eosinophil Superoxide Anion Generation K. Saito, M. Nagata, I. Kikuchi, Y. Sakamoto; Pulmonary Divi- sion, Saitama Medical School, Saitama, JAPAN.

Poster Session 4512


Therapy of Allergic Diseases: Molecular Mechanisms and Novel Therapeu- tics 774 Effect of Intravenous Administration of an Anti-IL-5 mAb

(Mepolizumab) on Allergen-Induced Tissue Eosinophilia, the Late-Phase Allergic Reaction and the Expression of a Marker of Repair/Remodeling in Human Atopic Subjects P. Flood-Page, S. Phipps, A. Menzies-Gow, Y. Ong, A. B. Kay; Allergy and Clinical Immunology, NHLI Division, Imperial Col- lege London, London, UNITED KINGDOM.

775 A Double-Blind, Placebo-Controlled Birch Allergy Vaccination Study: Inhibition of CD23-Mediated Serum-IgE Facilitated Allergen Presentation J. van Neerven 1, M. B. Arvidson 2, H. H. Jacobi 3, S. Rak 4, S. H. Sparholt 5, P. A. Wiirtzen6; ]MacroZyme BV, Amsterdam, NETHERLANDS, 2Dept. Resp. Med. and Allergology, Sahlgrens- ka University Hospital, G6teborg, SWEDEN, 3Research, ALK- Abell6, H0rsholm, DENMARK, 4Dept. Resp. Med. and Allergolo- gy, Sahlgrenska University Hospital, G6teborg, SWEDEN, 5Clinical Research, ALK-AbelI6, Hcrsholm, DENMARK, 6Research, ALK-AbelIo, H0rsholm, DENMARK.

r76 Efficacy and Safety of Ketotifen Fumarate Eye Drops as Adjunctive Therapy to Mometasone Furoate Nasal Spray in Subjects with Seasonal Allergic Rhinoconjunctivitis F. Horak ], P. Stuebner F, R. Zieglmayer I, C. L. McWhirter 2, M. Gekkieva3; lENT-University Clinic, Vienna, AUSTRIA, 2Novartis Ophthalmics, Inc, Duluth, GA, 3Novartis Ophthalmics AG, Buelach, SWITZERLAND.

177 Immuno-modulation in the Treatment of Eosinophilic Gas- troeuteritis E. Lu, Z. K. Ballas; Department of Intenml Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA.

778 Desloratadine Inhibits T-Cell Responses, Airway Inflamma- tion, and Bronchial Hyperresponsiveness (BHR) in Murine Models of Asthma P. J. Bryce, R. S. Geha, H. C. Oettgen; Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA.

779 Inhibitory Mechanism of New Compound (Alprogen) on the Mast Cell Activitation J. Ro I, J. Kim 1, J. Seo l, Y. Chung 2, Y. Park2; t Pharmacology, Sung Kyun Kwan University, Suwon, REPUBLIC OF KOREA, 2Gradu- ate School of Biotechnology, Korea University, Seoul, REPUBLIC OF KOREA.

780 Down-Regulation of Th2 Cytokines In Vitro by Immunomodu- latory Oligonucleotides (IMO) Containing Modified CpG Motifs K. D. Srivastava ], E. R. Kandimalla 2, D. Yu 2, S. Agrawal 2, H. A. Sampson I, X. Lil; tPediatrics, Mount Sinai School of Medicine, New York, NY, 2Hybridon Inc, Cambridge, MA.

781 T-Cell Mediated Gene Therapy for CIED in Mice A. Saeed I , I. H. Tarner 2, C. F. MichaeP, X. Du t , Y. Guo I , J. Yang I , A. W. James r, U. Nair ], G. G. Fathman 3, T. J. Yoo]; IAllergy/Immunology, Memphis, TN 38163, Memphis, TN, 2Uni- versity of Iowa, Iowa City, IA, 3Allergy/immunology, Stanford, CA.

782 Airway Inflammation and Hyperreactivity are Inhibited by Oral Administration of Desloratadine prior to Allergen Sensi- tization K. Bluemchen, K. Gerhold, I. Thorade, U. Wahn, E. Hamelmann; Dept. Pediatric Pneumology/lmmunology, University Hospital Charite, Berlin, GERMANY.

783 Effect of Anticancer Drugs on Survival of Human Mast Cells L. M. Preussner, J. Funke, K. Hartmann; Department of Derma- tology, University of Cologne, Cologne, GERMANY.

"/84 Dendritic Cell FceRI Expression Is Rapidly Down-Regulated With Omalizumab D. T. Griffith I , K. M. BoeseP, C. Prussin ~, B. Foster 2, H. Lin I , T. B. CasaleJ; 1Division of Allergy/Immunology, Department of Internal Medicine, Creighton University, Omaha, NE, 2Laboratory of Aller- gic Diseases, NIAID, National Institutes of Health, Bethesda, MD.

785 Desloratadine Mitigates the Degrauulation Process of Rat Peri- toneal Mast Cells in vitro Y. Wang t, Y. Tach6 I, A. G. Harris 2, W. Kreutner 2, J. Wei]; IDepartment of Medicine, UCLA, Los Angeles, CA, 2Schering- Plough Corp, Kenilworth, NJ.

786 A Dendritic Cell-Based Test System to Evaluate the Modulato- ry Potential of Drugs on Allergic Immunoreactioo H. Weigt, N. Krug, A. Braun; Fraunhofer ITA, Hannover, GER- MANY.

787 Rapid Reduction of Basophil FccRI Expression by Omalizumab K. M. BoeseU, D. T. Griffith ] , C. Prussin 2, B. Foster 2, H. Lin 1, T. B. Casalel; ] Division of Allergy/Immunology, Department of Internal Medicine, Creighton University, Omaha, NE. 2Laboratory of Aller- gic Diseases, NIAID, National Institutes of Health, Bethesda, MD.

788 The Effect of Corticosteroid on RANTES and IL-8 mRNA Expression in Human Bronchial Epithelial Cell Line Infected with Respiratory Syncytial Virus H. Kim], J. Lee2; ]Pediatric Allergy & Clin. Immunology, Catholic University of Korea, Puchon, REPUBLIC OF KOREA, 2Pediatric Allergy and Clin. Immunology, Catholic University of Korea, Puchon, REPUBLIC OF KOREA.

789 Vitamin C Inhibits Release of IL-4 and IFN-gamma from Rag- weed-Stimulated Mononuclear Cells M. J. de Vera, G. Li, J. N. Moy; Rush Medical College/Cook County Hospital, Chicago, IL.

790 Molecular Regulation of IL-13 Protein Expression From Mast Cells by Monokines: Effects of Cyclosporine and Dexamethasone S. Lee, S. Fitzgerald, K. Hall, S. Reynolds, D. S. Chi, G. Krish- naswamy; Internal Medicine, James H. Quillen College of Medi- cine and East Tennessee State University, Johnson City, TN.

791 Chitosan IFN-gamma-gene Nanosphere (CIN) Therapy for Allergic Asthma: Modulation of Specific T-Cell and Dendritic Cell Responses G. Hellerman l, X. Kong I, H. San Juan 1, R. E Lockey ], S. S. Mohapatra2; tUniv of South Florida Coil of Med & VA Hosp, Tampa, FL, 21nternal Medicine (MDC-19), Univ of South Florida Coil of Med, Tampa, FL.

792 Gene Therapy for Asthma in a Rat Model with lntratracheal Instillation of Plasmid Encoding Galectin-3 Gene C, Lahoz ], V. del Pozo I, M. Rojo l, M. Rubio 2, E. Lopez t, C. Martfn-Mosquero 2, S. Gallardo t. M. Ortega 2, E. Civantos t, I.


Cortegano 1, B. Cfirdaba I , G. Peces-Barba 2, R Palomino 1, N. Gon- zalez-Mangado2; llmmunology, Fundaci6n Jim6nez Diaz, Madrid, SPAIN, 2Pulmonology Dept., Fundaci6n Jim6nez Dfaz, Madrid, SPAIN.

793 The Role of Cysteinyl Leukotrienes (CysLTs) in Bone Marrow Responses in Murine Experimental Allergic Rhinitis: Blockade of Eosinophil Production and Tissue Eosinophilia by a CysLT1 Receptor Antagonist H. Saito 1,2, L. Crawford I, E. Denhurg I, J. A. Denburgl; IMcMas ter University, Hamilton, ON, CANADA, :Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

794 Budesonide Enhancement of Eosinophil Differentiation In Vitro Does Not Involve IL-5R(x Overexpression or Increased p38 MAP Kinase Activation A. J. Baatjes 1, R. Sehmi 1, S. C. DormanL R. Alam 2, R. Foley ], M D. InmanL P. M. O'Byrne ], J. A. Denburgl; JMcMaster Universi- ty, Hamilton, ON, CANADA, 2University of Texas Medical Branch, Galveston, TX.

795 Diamine Oxidase Activation by Diphenhydramine--In Vitro but No In Vivo Effect F. Wantke, W. Hemmer, M. Focke, M. G6tz, R. Jarisch; FAZ-Floridsdorf Allergy Centre, Vienna, AUSTRIA.


Monday, March 10 2:15 PM to 3:45 PM

Best of ARRD Abstracts I 2.'15 796 Seasonal Variation in Asthma-Related Hospital and ICU

Admissions T. B. Pendergraf t l, D. Stempel 2, C. Roberts 3, R. StanfordL Y. Shen3; IGlaxoSmithKline, Research Triangle Park, NC, 2Universi ty of Washington, Seattle, WA, 3NDCHealth, Yardley, PA.

2:30 797

2:45 798

3:00 799

3:15 800

Nerve Growth Factor is Increased in Bronchoalveolar Lavage Fluid After Experimental Rhinovirus Infection G. R. Jenkins, S. C. Christiansen, J. Eddleston, B. L. Zuraw; Mol- ecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.

Allergen-Selective Redirection of Immunoregulatory Respons- es in Ragweed-Allergic Humans Using Dynavax Amb a 1 Immunostimulatory Oligodeoxyribonucleotide Conjugate (AIC) F. E. R. Simons I, Y. Shikishima 2, G. van Nest 2, J. J. Eiden 2, K. T. HayGlass3; I Department of Pediatrics & Child Health, University of Manitoba, Winnipeg, MB, CANADA, 2Dynavax Technologies Corporation, Berkley, CA, 3Department of Immunology, Universi ty of Manitoba, Winnipeg, MB, CANADA.

Grass Pollen Immunotherapy for Two Years Has Sustained Effects During Two Years Double-Blind Placebo-Controlled Withdrawal of Treatment S. M. Walker l, M. Jacobson 2, S. R. Durham2; INational Respira- tory Training Centre, Warwick, UNITED KINGDOM, 2Upper Respiratory Medicine, National Heart & Lung Institute, London, UNITED KINGDOM.

Use of Inhaled Corticosteroids (CS) During Pregnancy Does Not Reduce Fetal Growth J. A. Namazy I, M. Schatz 2, L. Long 2, D. Petitti3: ]Allergy, Scripps Clinic, La Jolla, CA, 2Allergy, Kaiser-Permanente Medical Center, San Diego, CA, 3Research and Evaluation, Kaiser-Permanente Medical Center, Pasadena, CA.

3:30 801 Effects of Anti-eotaxin Monoclonal Antibody CAT-213 on

Allergen-induced Rhinitis S. Pereira 1, T. Clark 2, Y. Darby 3, R. Salib 4, M. Salagean 4, L. Hewitt 5, J. Powell 6, P. Howarth 4, G. Scadding3; qmmunology Department, Northwick Park Hospital, London, UNITED KING- DOM, 2University College London, London, UNITED KING- DOM, 3Clinical Immunology, Allergy and Rhinology Department, Royal National Throat, Nose and Ear Hospital, London, UNITED KINGDOM, 4Division of Respiratory Cell and Molecular Biology, University of Southampton, Southampton, UNITED KINGDOM, SMedical Specialties, University of Southampton, Southampton, UNITED KINGDOM, 6Medical Development Department, Cam- bridge Antibody Technology, Cambridge, UNITED KINGDOM.



Best of ARRD Abstracts 11 2:15 802 IgE to Staphylococcus Aureus Enterotoxins (SAEs) in Patients

with Asthma C. Bacher t I, P. Gevaert ], P. Howarth 2, G. Holtappels ], P. van Cauwenberge I, G. Johansson3; lENT-Department, Universitair Ziekenhuis, Ghent, BELGIUM, 2Medical Specialities, General Hospital, Southampton, UNITED KINGDOM, 3Laboratory Medi- cine, Karolinska Hospital, Stockholm, SWEDEN.

2:30 803

2:45 804

3:00

805

3:15 806

3:30 807

High Serum Leptin Levels in Asthmatic Children N. Giiler ], E. Kirerleri 2, 0. ()nes 3, N. Salmayenli 4, Z. TamayS; ipediatric Allergy, lstanbul University, lstanbul, TURKEY 2Department of Pediatric Allergy, lstanbul Medical Faculty, Istan bul, TURKEY, 3Department of Pediatrics, Istanbul Medical Uni vercity, Istanbul, TURKEY, 4Department of Biochemistry, lstanbu Medical Faculty, Istanbul, TURKEY, 5Department of Pediatrics Istanbul Medical Faculty, lstanhul. TURKEY.

Airway Remodeling and Endobronchial Gene Expression il Asthma P. Beckett, P. H. Howarth; RCMB Division, University o Southampton, Southampton, UNITED KINGDOM.

Airway Responsiveness to Beta-Agonist and Beta2-Adrenocep tor Gene Polymorphisms K. Asano 1, Y. Suzuki ], T. Shiomi I, T. Nakajima I, H. Kudoh I, 1 Matsuzaki I, W. Yamada I, R. Hiraoka ], K. Yamaguchi i, A Nagabukuro 2. Y. Harada2; IKeio University School of Medicine, Tokyo, JAPAN, 2Otsuka Pharmaceutical Co Ltd TRC, Tokushima, JAPAN.

Comparative Efficacy of Asthma Treatments: Impact of Aller- gic vs Non-allergic Status on Response to Therapy K. Rickard, P. Dorinsky, S. Yancey, A. Emmett; GlaxoSmithKline, Research Triangle Park, NC.

Lower-Leg Growth in Chi ldren with Asthma During Treat- ment with Inhaled Corticosteroids S. Pedersen ], L. Agertofi I, T. Lee 2, H. Staudinger2; IDepartment of Pediatrics, Kolding Hospital, University of Odense, Kolding, DENMARK, 2Schering-Plough Research Institute, Kenilworth, NJ.




BC! 2003: From Cells to Genes 2:15 808

2:30 809

2:45 810

3:00 811

3.:15 812

3:30 813

Defining the Genomic Response to Allergen Challenge in Murine Asthma N. G. Dharajiya j, B. K. Choudhury |, B. Clancy z, R. Alam ], S. Surl; INIH Asthma and Allergic Disease Research Center and Department of Internal Medicine, UTMB, Galveston, TX, 2Wyeth Erst, Andover, MA.

Cytokine Gene Polymorphisms Moderate Illness Severity in Infants with Respiratory Syncytial Virus (RSV) Infection J. A. Howe-Adams, D. A. Gentile, A. Zeevi, J. Trecki, B. L. Angelini, D. P. Skoner; Department of Pediatrics, Children's Hos- pital of Pittsburgh, Pittsburgh, PA.

Sequence Variants of the Gene Encoding Chemoattractant Receptor Expressed on Th2 Cells (CRTH2) is Associated with Asthma in an African American (AA) Population S. K. Huang 1, R. A. Mathias i, E. Ehrlich I, B. Plunkett 1, A. Togias 1, K. C. Barnes ], E Malveaux 2, T. H. BeatyJ; I Johns Hop- kins University, Baltimore, MD, 2Howard University, Washington, DC, 3Johns Hopkins University School of Public Health, Balti- more, MD.

Th2 Dominance and Defective CD8 + Dendritic Subset in Id2- Deficient Mice 1". Kusunoki ], M. Sugai 2, T. Katakai 2, Y. Omatsu 3, T. lyoda 3, K. lnaba 3, T. Nakahata I, A. Shimizu 2, Y. Yokota4; JDepartment of Pediatrics, Kyoto University, Kyoto, JAPAN, 2Center for Molecu- lar Biology and Genetics, Kyoto University, Kyoto, JAPAN, 3Department of Animal Development and Physiology, Kyoto Uni- versity, Kyoto, JAPAN, 4Department of Biochemistry, Fukui Med- ical School, Kyoto, JAPAN.

The TranscriptionFactor CP2 is Required for IL-4 Gene Acti- vation in Effector Th Cells R. J. Kurnat j, S. N. Georas 1, S. Curry I , X. Meng 1, S. Huang 1, J. M. Cunningham 2, C. Stellato l, V. Casolarol; IThe Johns Hopkins Asthma and Allergy Center, Baltimore, MD, 2St. Jude Children's Research Hospital, Memphis, TN.

Normal Distribution of Peripheral Blood Mononuclear Cell (PBMC) Subsets from Birth to 18 Years: The NIH NIAID DAIDS Pediatric AIDS Clinical Trial Group P-1009 Protocol W. T. Shearer I , H. M. Rosenblatt l, S. A. Spector 2, E. R. Stiehm 3, D. W. Wara 4, S. D. Douglas s, K. Luzuriaga 6, E. J. McFarland 7, R. Yogev s, M. H. Rathore 9, W. Levy 1~ B. L. Graham II , R. Oyomopi- to ~2, R. S. GelmanlJ; IBaylor College of Medicine, Houston, TX, 2University of California, San Diego, La Jolla, CA, 3University of California, Los Angeles, Los Angeles, CA, 4University of Califor- nia, San Francisco, San Francisco, CA, 5Children's Hospital of Philadelphia, Philadelphia, PA, 6University of Massachusetts, Worcester, MA, 7University of Colorado Health Sciences Center, Denver, CO, 8Children's Memorial Hospital, Chicago, IL, 9Univer- sity of Florida, Jacksonville, FL, i~ & Scientific Systems, Silver Spring, MD, l lFrontier Science & Technology Research Foundation, Amherst, NY, 12Harvard School of Public Health, Boston, MA, 13Dana-Farber Cancer Institute, Boston, MA.



Mechanisms and Novel Therapeutics in Ocular and Dermatologie Diseases 2:15 814 Staphylococcus aureus Peptidoglyean Upregulates Expression

of Toll-Like Receptor 2, CD14, ICAM-1, HLA-DR and Release of TNFc~ and IL-8 from Human Conjunctival Epithelial Cells E. B. Cook l, J. L. StahP, F. M. Graziano i , N. P. Barney2; 1Medicine, University of Wisconsin-Madison, Madison, WI, 2Ophthalmology & Visual Sciences, University of Wisconsin-Madison, Madison, WI.

2:30 815 Subcutaneous Injection of Killed Mycobacterium vaccae

(SRP299) Soon after Birth Delays the Onset and Ameliorates the Clinical Course of Dermatitis in NC/Nga Mice P. D. Arkwright I, C. Fujisawa 2, A. Tanaka 2, H. Matsuda2; IChild Health, University of Manchester, Manchester, UNITED KING- DOM, 2Clinical Immunology, Tokyo University of Agriculture and Technology, Tokyo, JAPAN.

2:45 816 Suppression of Innate Immune Response Genes in the Skin of

Atopic Dermatitis (AD) I. Nomura I , P. Y. Ong 2, E. Goleva I , M. Boguniewicz I , C. Hall l, J. B. Travers 3, Q. A. Hamid 4, D. Y. M. Leung I; 1 Pediatrics, National Jewish Medical & Research Center, Denver, CO, 2White Memorial Pediatric Medical Group, Los, Angeles, CA, 3Dermatology and Pharmacology, Indiana University Medical Center, Indianapolis, IN, 4Meakins- Christie Laboratories, McGill University, Montrfal, PQ, CANADA.

3:00 817 NKT Cell-derived IL-4 is Required Early in Allergic Contact

Sensitivity (CS) R. A. Campos ], M. Szczepanik i, A. Itakura I, M. Kronenberg 2, P. W. Askenasel; qntemal Medicine, Yale University School of Med- icine, New Haven, CT, 2Division of Developmental Immunology, La Jolla Institute for Allergy, San Diego, CA.

3:15 818 Non-Steroidal Anti-Inflammatory Drugs (NSAID) Sensitivity

in Chronic Idiopathic Urticaria (CIU): Selective Involvement of Cyclooxygenase I (COX-I) and Overproduction of Cys- teinyl-Leukotrienes (cys-LTs) M. Setkowicz I , A. Zembowicz 2, L. Mastalerz 3, W. Radziszewski 4, A. Szczeklik~; ]Department of Dermatology, Jagiellonian Univer- sity School of Medicine, Cracow, POLAND, 2Department of Pathology, Harvard Medical School, Boston, MA, 3Department of Medcine, Jagiellonian University School of Medicine, Cracow, POLAND, 4Merck, Sharp & Dohme Poland, Warsaw, POLAND, SDepartment of Medicine, Jagiellonian University School of Med- icine, Cracow, POLAND.

3:30 819 ENBREL (Etanereept) Monotherapy in Patients with Psoria-

sis: Clinical and Pathologic Improvements A. S. Nayak I, R. Zitnik2; IPeoria School of Medicine, Peoria, 1L, 2Amgen, Seattle, WA.



Hot Topics in EOD: Agents Responsible for Environmental Allergic Respi- ratory Disease 2:15 820 Prevalence of Respiratory Symptoms During the First Year

of Life and Combined Exposure to Indoor NO 2 and Indoor Allergens R. T. van Strien I, K. Belanger I, E. Triche I, U. Gehring e, M. B. Bracken i, B. P. Leaderer I: I Center for Perinatal, Pediatric and Envi-


2:30 821

2:45 822

3:00 823

3:15 824

3:30 825

ronmental Epidemiology, Yale University School of Medicine, New Haven, CT, 2Institute of Epidemiology, GSF-National Research Centre for Environment and Health, Neuherberg, GERMANY.

The Dominance of Dust Mite Allergy in Wheezing Among Chil- dren in New Zealand Is Not Reduced by the Presence of a Cat E. A. Erwin ~, D. M, Riposo I, K. Wickens 2, D. Barry 2, N. J. Custis I, J. Crane 2, T. A. E. Platts-Millsi; JUniv VA Asthma/Aller- gic Diseases Center, Charlottesville, VA, 2Wellington School of Medicine, Wellington South, NEW ZEALAND.

Risk of Sensitization and Asthma at Four Years in a Birth Cohort with Selection of Pet Ownership C. AImqvist j, A. Egmar l, M. van Hage-Hamsten 2, G. Hedlin 3, L. Nordvall 4, G. Pershagen 5, M. Svartengren 6, M. Wickmanl; ~Dept of Environmental Health, Stockholm, SWEDEN, 2Dept of Clinical Immunology and Allergy, Stockholm, SWEDEN, 31nst of Woman and Child Health, Stockholm, SWEDEN, 41nst of Woman and Child Health, Uppsala, SWEDEN, 5Inst of Environmental Medi- cine, Stockholm, SWEDEN, 6Dept of Public Health Sciences, Stockholm, SWEDEN.

The Modified Th2 Response to Cat: Mechanisms of T-Cell Tol- erance A. J. Reefer j, S. J. Sung 2, T. A. E. Platts-Mills I, J. A. Woodfoikl; IAsthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA, 2Department of Rheumatology, University of Virginia, Charlottesville, VA.

Effects of Pet Ownership on Patterns of Cytokine Secretion and Allergen Sensitization in Infancy C. Rock I , Z. Li 2, K. A. Roberg ~, K. Carlson-Dakes ~ , C. Tisler ~ , D. Da Silva I, R. Gangnon 2, R. E LemanskO, J. E. Gernl; 1Pediatrics, University of Wisconsin, Madison, WI, 2Biostatistics, University of Wisconsin, Madison, WI.

lgE Sensitization to Bacillus Thuringiensis- and Verticillium Lecanii-derived Biopesticides in Danish Greenhouse Workers G. Doekes j, P. Larsen 2, T. Sigsgaard 3, J. Baelum2; qnstitute for Risk Assessment Sciences, University Utrecht, Utrecht, NETHER- LANDS, 2Occupational and Environmental Medicine, University Hospital, Odense, DENMARK, 3Environmental and Occupational Medicine, University of Aarhus, Aarhus, DENMARK.

2:45 828

3:00 829

3:15 830

3.'30 831

Allergen Homologues as Desensitizing Reagents J. S. Stanley j,2, R. M. Helm j,2, U. Ponnappan 3, H. A. Sampson 4. A. W. BurksL2; 1pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children's Hospital, Little Rock, AR, 3Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR. 4Mt. Sinai School of Medicine, New York, NY.

Logistic Regression Analysis of Values of Skin Testing and IgE Antibodies to Predict Actual Clinical Allergy to Shrimp in Adult Subjects J. Rodriguez, P. Poza-Guedes, J. E Crespo, P. Daroca, A. G6mez- Cfimara, M. L. Somoza, R. Vives; Allergy Department, Hospital Universitario Doce de Octubre, Madrid, SPAIN.

Recurrence of Peanut Allergy Cannot Be Predicted by Contin- ued Peanut Avoidance or Serum Specific IgE J. M. Factor, L. M. Mendelson, J. P. Rosen; Connecticut Asthma and Allergy Center, West Hartford, CT.

Relevance of Casual Contact to Peanut Butter in Peanut-Aller- gic Children S. J. Simonte, A. P. Brown, S. Mofidi, S. H. Sicherer; Pediatrics, Mount Sinai School of Medicine, New York, NY.



Asthma Health Care Delivery 2:15 832 Validity of a Parental Survey for School-Based Asthma Screening

M. C. Li ~, M. Dyer I, L. T. Clemen0, K. Y. Kwong I, N. B. Maalouf ~, J. Hanley-Lopez I, T. Kimia J, K. Feliciano I, T. L. Mor- phew j, E J. Lison 2, C. A. Jonesl; tAIlergy and Immunology, LAC+USC Medical Center, Los Angeles, CA, 2Southern Califor- nia Chapter of the Asthma and Allergy Foundation of America, Los Angeles, CA.

2:30 833

Oral Abstract Session 4 7 0 6

M o n d a y , M a r c h 10 2 :15 P M to 3 :45 P M 2..45

Food Allergy: Novel Therapeutic Interventions and MORE!! 834 2:15 826 Effect of Anti-IgE Therapy (TNX-901) in Patients with Severe

Peanut Allergy D. Y. M. Leung r , H. A. Sampson 2, J. W. Yunginger 3, W. Burks 4, L. C. Schneider 5, W. Shanahan6; IPediatrics, National Jewish Medical & Research Center, Denver, CO, 2Pediatrics, Mt, Sinai/NYM Med- 3.'00 ical Center, New York, NY, 3Allergic Diseases, Mayo Clinic, 835 Rochester, MN, 4pediatrics, Arkansas Children's Hospital, Little Rock, AR, 5Children's Hospital, Boston, MA, 6Tanox, Inc, Hous- ton, TX.

Pilot Study of Anti-IL-5 in Eosinophilic Gastroenteritis C. Prussin I, S. P. James 2. M. M. Huber 2, A. D. Klion 2, O. D. Met- caller; tLaboratory of Allergic Diseases, NIAID, National Insti- tutes of Health, Bethesda, MD, 2National Institutes of Health, Bethesda, MD.

2:30 827

3:15 836

Results of a Telemedicine Program for Managing Asthma in a Correctional Population J. A. Gran t I, D. Cheesman 2, H. Jones 2, W. Givens 2, O. Murray 2, B. Vincent 2, G. Adams 2, E. Coffey2; IAllergy-lmmunology, Uni- versity Texas Medical Branch, Galveston, TX, 2Correctional Man- aged Health Care, University of Texas Medical Branch, Galveston, TX.

Inhaled Corticosteroids and Allergy Specialty Care Reduce Emergency Hospital Utilization for Asthma in an HMO Popu- lation M. Schat# , E Cook 2, R. Nakahiro I, D. Petittil; IKaiser-Perma- nente Medical Center, San Diego, CA, 2Harvard School of Public Health, Boston, MA.

Training Head Start Family Services Coordinators (FSCs) to Provide Case Management Services to Children with Asthma B. CalabresO, B. Adams I, M. Kowzan j, K. Rieker0, K. Huss 2, A. Butz I, M. L. Winkelstein 2, P. A. Eggleston I, C. S. RandJ; JSchool of Medicine, Johns Hopkins University, Baltimore, MD, 2School of Nursing, Johns Hopkins University, Baltimore, MD.

Duration of Symptoms before Diagnosis of Asthma in Children M. D. Cabana, K. Slish, N. Clark; University of Michigan, Ann Arbor, MI.


3:30 837 Parental Knowledge Regarding Asthma Medications

E M. Keefe t, J. A. Pongracic L, H. J. Binns2; 1Allergy, Children's Memorial Hospital, Chicago, IL, 2Pediatrics, Children's Memorial 9.'00 Hospital, Chicago, IL. 845



Mechanisms of AlletxT: Best Abstracts 9:15 2:15 846 838 Soluble Tumor Necrosis Factor Alpha (TNF-alpha) Receptor

(Enbrel) as an Effective Therapeutic Strategy in Chronic Severe Asthma K. Babu 1, S. H. Arshad t, P. H. Howarth i, A. J. Chauhan 2, E. J. Bell I, S. Puddicombe 1, D. E. Davies 1, S. T. Holgatet ; IRespiratory 9:30 Cell & Molecular Biology, Southampton University Hospital, 847 Southampton, UNITED KINGDOM, 2Respiratory Medicine, St. Mary's Hospital, Portsmouth, UNITED KINGDOM.

2:30 839 Anti-IL-5 (Mepolizumab) Reduces the Expression of Tenascin,

Proeollagen III and Lumican in the Reticular Basement Mem- 9:45 brane of Human Atopic Asthmatics 848 S. Phipps I, P. Flood-Page t, A. Menzies-Gow j, A. Wangoo 1, N. Barnes 2, J. Barkans 1, D. Robinso#, A. B. Kayl; JAllergy and Clin- ical Immunology, NHLI Division, Imperial College London, Lon- don, UNITED KINGDOM, 2Respiratory Medicine, London Chest Hospital, London, UNITED KINGDOM.

2:45 10:00 840 CRIC3, a Chemokine Receptor Inactivator as a Novel 849

Approach in the Treatment of Allergic Diseases J. Eisner I , 1. Hartung I , R. B~ider 2, S. E. Escher 3, N. Spodsberg 3, Y. Dulkys I, M. Walden 3, A. Heitland 3, S. Senger I, A. Braun 2, W. G. Forssmann 3, U. Forssmann3; 1Department of Dermatology and Aller- gology, Medical Center Hannover, Academic Teaching Unit, Han- nover Medical School, Hannover, GERMANY, 2Drug Research and 10:15 Clinical Inhalation, Fraunhofer Institute of Toxicology and Aerosol 850 Research, Hannover, GERMANY, 3IPF PharmaCeuticals GmbH, An- Institut of the Hannover Medical School, Hannover, GERMANY.

Intratracheal Interieukin-13 Induces Eosinophilic Esophagitis (EE) A. Mishra, M. E. Rothenberg; Allergy and Immunology, Chil- dren's Hospital Medical Center, Cincinnati, OH. 10:30

3:15 851

842 FcaRI-Mediated Activation of Human Mast Cells (HuMCs) Is Regulated by an Early PI-3 Kinase Independent, and a Delayed PI-3 Kinase Dependent Pathway C. Tkaczyk, D. D. Metcalfe, A. M, Gilfillan; Laboratory of Aller- gic Diseases, NIAID, National Institutes of Health, Bethesda, MD.

3:30 843 Development of Asthma Phenotype in ADA and Ragl Double

Deficient Mice L. L. Chan l, S. Sur 2, R. Alam ~-, J. S. Wild 2, T. Chan3; IHuman Biological Chemistry & Genetics, University of Texas Medical Branch, Galveston, TX, 2Internal Medicine, University of Texas Medical Branch, Galveston, TX, 3Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX.


Tuesday, March 11 8:45 AM to 10:45 AM

Asthma Mechanisms I 8:45 844 Diminished Dendritic Cell (DC) IL-10 Production and Enhanced

T Helper Lymphocyte Type 2 (Th2) Cytokine Responses during Infancy

3:00 841

D, A. Gentile, J. Howe-Adams, J. Trecki, A. Patel, P. Fireman, D. P. Skoner; Department of Pediatrics, Children's Hospital of Pitts- burgh, Pittsburgh, PA.

Expression of the Apoptosis Inhibi tor "Bcl-2" in Sputum Eosinophils from Children with Acute Asthma Y. M. EI-GamaU, N. M. Heshma0, M. Z. Mahran 2, Z. M. E1-Gab- basl; IPediatric, Ain-Shams University, Faculty of Medicine, Cairo 11111, EGYPT, 2Clinical Pathology, Ain-Shams University, Facul- ty of Medicine, Cairo 11111, EGYPT.

Responses of Bone-Marrow Eosinophil/Basophil Progenitors in Experimental Mouse Models of Upper and/or Lower Airway Inflammation J. Li, H. Saito, L. Crawford, J. A. Denburg; Department of Medi- cine, McMaster University, Hamilton, ON, CANADA.

Antigen-Primed CD8+ T Cells Are Necessary for the Develop- ment of Airway Hyperresponsiveness and Airway Inflammation N. Miyahara, K. Takeda, T. Kodama, A. Joetham, A. Dakhama, C. Taube, J. Park, A. Balhorn, E. W. Gelfand; Pediatrics, National Jewish Medical and Research Center, Denver, CO.

Pulmonary Stat6 is Required for Eosinophil Trafficking into the Asthmatic Lung S, J. Hong i , B. D. Medofl 2, A. D. Carafone 2, A. D. Luster2; tDivi- sion of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Massa- chusetts General Hospital/Harvard Medical School, Boston, MA.

Role of the High-Affinity IgE Receptor (FcERI) in the Develop- ment of Airway Hyperresponsiveness (AHR) C. Taube, X. Wei, A. Joetham, J. Park. K. Takeda, N. Miyahara, T. Kodama, J. Loader, G. L. Larsen, G. L. Larsen, A. Balhorn, A. Dakhama, E. W. Gelfand, Pediatrics, National Jewish Medical and Research Center, Denver, CO.

Late Asthmatic Reactions Provoked by Intradermal, but Not Inhaled, Allergen-Derived T-Cell Peptides Induce "Tolerance" to Subsequent Antigen Challenge F. R. All, J. Arbery, M. Larch~, A. B. Kay; Allergy and Clinical Immunology, NHLI Division, Imperial College London, London, UNITED KINGDOM.

Increased Plasma Cortisol Might Explain the Depressed Th-1 Type Lymphocyte Function in Severe Respiratory Syncytial Virus Infected Infants P. V. Dfaz t, R. A. Pinto 2, M. R. Bono 3, S. M. Arredondo 4, A. Gag- ger05; tPathophysiology, ICBM, Faculty of Medicine, University of Chile, Santiago, CHILE, 2Pediatrics, Faculty of Medicine, Uni- versity of Chile, Santiago, CHILE, 3Immunology, Faculty of Sci- ences, University of Chile, Santiago, CHILE, 4Immunology, INT, Santiago, CHILE, 5Virology, ICBM, Faculty of Medicine, Univer- sity of Chile, Santiago, CHILE.



Signaling and Apoptosis 8.'45 852 Spl/Sp3 and Pax-5 Transcription Factors Mediate Activation

of the Germinal Center B-Cell-Specific M17 Promoter J. W. Steinke i, A. M. Owens 2, J. Hagman 3, L. Borisht; 1Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, 2Asthma and Allergic Disease Center, Univer- sity of Virginia Health Systems, Charlottesville, VA, 3National Jewish Medical and Research Center, Denver, CO.

J ALLERGY CLIN iMMUNOL A b s t r a c t s $397 VOLUME 111, NUMBER 2

9:00 853

9:00 861 Stem Cell Factor Modulates Human Mast Cell Apoptosis

Induced by TNF Receptor-Like Apoptosis-Inducing Ligand (TRAIL) Receptor Activation A. M. Piliponsky i , I. Daigle 2, B. Berent l, H. Simon 2,3, E Levi- SchaffeH; IPharmacology, The Hebrew University of Jerusalem, 9:15 Jerusalem, ISRAEL, 2Swiss Institute of Allergy and Asthma 862 Research (S1AF), Davos, SWITZERLAND, 3pharmacology, Uni- versity of Bern, Bern, SWITZERLAND.

9:15 854 A Persistent and Selective Activation of Syk or ZAP.70 Kinase

Precedes a Thl or Th2 On-Switch J. Tan j , A. Liu j , H. H. JacobP, C. Glue 2, A. Millner I , H. O. Madsen 3, 9:30 L. P. Ryder3, A. Svejgaard3, J. N. Larsenl, P. A. Wurtzenl, E S. Skov 2 , 863 H. Malling 2, M. Spangford, L. K. Poulsen2; IBiological Allergy Research, ALK-AbelIo A/S, H0rsholm, DENMARK, 2Laboratory of Medical Allergology, Allergy Unit, National University Hospital, Copenhagen, DENMARK, 3Department of Clinical Immunology, 9:45 National University Hospital, Copenhagen, DENMARK. 864

9:30 855 Arginine 27, a Conserved Methylation Site in Stat6, Is Essen-

tial for IL-4-Induced Tyrosine-Phosphorylation, DNA Binding Activity, and Nuclear Translocation of Stat6 W. Chen, M. O. Daines, G. K. Khurana Hershey; Division of Allergy & Immunology, Children's Hospital Medical Center, Cincinnati, OH.

9:45 856 Splice Variant in ToCell Receptor ~ Chain Occurs in a Region 10:00

with Homology to G-protein 7 Chain 666 T. P. Atkinson I , C. G. Hall 2, S. Skoda-Smith 3, J. Goldsmith 4, P. M. KirkhamS; i pediatrics, University of Alabama at Birmingham, Birm- ingham, AL, 2pathology, University of Alabama at Birminghan, Birmingham, AL, 3pediatrics, University of Florida, Gainesville, FL, 10:15 4University of Alabama at Birmingham, Birmingham, AL, 5pharma- 866 cology, University of Alabama at Birmingham, Birmingham, AL.

10:00 657 Airway Epithelial Cells Express Multiple Members of the B7

Family 10:30 J. R~ Plitt I, S. Kurasawa I, L. Chen 2, B. S. Bochner l, R .P . 867 Schleimerl; i Medicine, Johns Hopkins University, Baltimore, MD, 2Mayo Clinic, Rochester, MN.

10.'15 858 Dinucleotide (GT) Repeat Variants in the First Exon of the

STAT6 Gene Differentially Regulate the Promoter Activity In Vitro P. S. Gao, N. M. Heller, B. Plunkett, R. P. Schleimer, S. K. Huang; Johns Hopkins University, Baltimore, MD.

10:30 659 Desloratadine Exhibits Inverse Agonism and Inhibits NFkB

Activity R. Wu, J. C. Anthes, W. Kreutner, A. Harris, M. Billah, R, W. Egan. R. E. West, Jr.; Schering-Plough Research Institute, Kenil- worth, NJ.



Cytokines and Immunomodu~tion 8:45 660 Synergistic Effects of Cytokines and Corticosteroid on TLR2

Expression in Human Respiratory Epithelial Cells T. Homma j,2, N. HashimotoL A. Kato 1,2, M. YoshikawaL H. Saito I, K. Matsumotot ; IDepartment of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, JAPAN, 2Genox Research, lnc, Kawasaki, JAPAN.

CD4+CD25 + 1L-10-Producing Cells Are Increased in the Peripheral Blood Following Grass Pollen Immunotherapy J. N. Francis, S. J. Till, S. R. Durham; Upper Respiratory Medi- cine, Imperial College, London, UNITED KINGDOM.

Interferon-oJ[3 Receptor-mediated Selective Induction of an Anti-viral Gene Cluster by CpG Oligodeoxynncleotide 2006 A. Kato j,2, T. Homma 1,2, N. Hashimoto ], H. Saito l, K. Matsumo- tot; iAllergy & Immunology, National Research Institute for Child Health & Development, Tokyo, JAPAN, 2Genox Research, Inc, Kawasaki, JAPAN.

Modulation of Cockroach Allergy by Vaccination with Plasmid DNA Encoding Blag-2 in Mice J. Yang, U. Nair, X. Du, T. J. Yoo; Allergy/Immunology, Memphis, TN.

IL-10 Inhibits Allergen-Specific TH2 Chemokine Production but not Chemokine Receptor Expression by Human Peripher- al Blood Mononuclear Cells in Ragweed Allergic Subjects B. Wong j , E. Cates 2, M. Conway 2, A. Dalrymple 2, S. Goncharova 3, M. Stampfli 3, J. Sun 3, S. Waserman j , M. Jordana3; IDivision of Aller- gy & Clinical Immunology, Department of Internal Medicine, McMaster University, Hamilton, ON, CANADA, 2McMaster Univer- sity, Hamilton, ON, CANADA, 3Department of Pathology and Mol- ecular Medicine, McMaster University, Hamilton, ON, CANADA.

IL-13 Q130 Variant Displays Increased Activity Compared to Wild Type R130 IL-13 M. Ericksen, W. Chen, G. K. Khurana Hershey; Cincinnati Chil- dren's Hospital Medical Center, Cincinnati, OH.

Generation of a Therapeutic Anti-lgE Response in a Primate Model through Vaccination S. Persson, M. Lundgren, L. Hellman; Resistentia Pharmaceuticals AB, Uppsala, SWEDEN.

Nasal Administration of Birch Pollen Allergen Formulated with Proteosome TM Adjuvant to Sensitized Mice Induces Increased IFN-y and IgG2a That Persist and are Associated with Suppression of Increases in Antigen-Specific IgE Follow- ing Allergen Challenge C. R. Rioux, A. M. Gelinas, H. Diamantakis, N. Bellerose, S. Tran, M. Plante, G. H, Lowell, D. S. Burt; ID Biomedical Corporation of Quebec, Ville Saint-Laurent, PQ, CANADA.



Hygiene Hypothesis and Environmental Risk Factors for Asthma 8:45 868 Viral Infections in Relation to Age and the Atopic Status of

Children Hospitalized for Wheezing H. T. Carper I, D. D. Murphy I, J. W. Steinke 2, M. S. Shaker j, A. P. McLanghlin j, T. A. E. Platts-Mills 2, R W. HeymannJ; ~Pediatrics, University of Virginia, Charlottesville, VA, 2Internal Medicine, University of Virginia, Charlottesville, VA.

9:00 869 Effect of Farming Environment on Atopic Diseases in Mongolia

A. Viinanen i, S. Munhbayarlah 2, T. Zevgee 2, T. Tseregmaa 2, L. Narantsetseg 2, T. Naidansuren 3, T. Lkhagwasuren 2, M. Kosken- vuo 4, H. Helenius 5, E. O. Terhol; IPulmonary Diseases and Clini- cal Allergology, University of Turku. Turku, FINLAND, 2patho-


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physiology, National Medical University of Mongolia, Ulaan- baatar, MONGOLIA, 3pulmonary Diseases, National Medical Uni- versity of Mongolia, Ulaanbaatar, MONGOLIA, 4public Health, University of Turku, Turku, FINLAND, 5Biostatistics, University of Turku, Turku, FINLAND.

Paradoxical Effect of Cow Dung Exposure on Childhood Atopy in Rural and Urban Children in South India P. K. Vedanthan; University of Colorado Health Sciences, Denver, CO.

Does the Immune Response to Cat Among Children Living with a Cat Influence the Prevalence of IgE to Dog and Birch? M. S. Perzanowski 1,2, E. Ronmark 2, K. Kemi-Bjornstrom 2, D. Riposo l, B, Lundback 2,3, T. A. E. Platts-Millsl; IAsthma and Aller- gic Diseases Center, University of Virginia, Charlottesville, VA, eObstructive Lung Disease in Northern Sweden Study Group, Lulea, SWEDEN, 3Karolinska Institutet, Stockholm, SWEDEN.

The Effect of Mite Allergen-Impermeable Covers in Adult Asthma: The SMAC Study A. Woodcock I, L. Forster 2, E. Matthews 2, J. Martin 2, L. Letley 2, M. Vickers 2, J. Britton 3, D. Strachan 4, P. Howarth 5, D. Ahmann 6, C. Frost 6, A. Custovicl; INorth West Lung Centre, Manchester, UNITED KINGDOM, 2Medical Research Council General Prac- tice Research Framework, London, UNITED KINGDOM, 3Divi- sion of Respiratory Medicine, University of Nottingham, Notting- ham, UNITED KINGDOM, 4Department of Public Health Sciences, St. George's Hospital Medical School, London, UNITED KINGDOM, 5Southampton General Hospital, Southampton, UNITED KINGDOM, 6London School of Hygiene and Tropical Medicine, London, UNITED KINGDOM.

Dust and Airborne Endotoxins Exposure in the Urban Dwellings of Strasbourg Area, France C. Sohy I , E Lieutier-Colas 2, A. Lintz 2, A. Verot 2, P. Meyer 3, G. Pauli 2, F. de Blay2; JService de Pneumologie, H6pital Lyautey, H0pitaux Universitaires de Strasbourg, FRANCE, 2Service de Pneumologie, H6pital Lyautey, H6pitaux Universitaires de Stras- bourg, FRANCE, 3Service de Biostatistiques et Informatique, H6pitaux Universitaires de Strasbourg, FRANCE.

Effects of Home Visitation on ETS Exposure Among Wheezing Children from Low-Income Families M. R. Price I , A. S. Kaugars 1,2, M. de la Garza 1, M. P. Lynch I , M. D. Klinnertt.2; IPediatrics, National Jewish Medical and Research Center, Denver, CO, 2Psychiatry, University of Colorado Health Sciences Center, Denver, CO.

Polycyclic Aromatic Hydrocarbons (PAHs) Enhance IgE-Medi- ated Histamine Release and IL-4 Production in Human Basophils C. Kepley I, L. Fredine 2, J. M. Oliver 2, S. Burchiel2; IMedical Col- lege of Virginia, Richmond, VA, 2University of New Mexico, Albu- querque, NM.

Or a l Abs t rac t Session 5115


Drug Hypersensitivity." Novel Management Strategies and Unusual Reactions 8:45 876 Antibiotic Desensitization for the Allergic Patient: 5 Years of

Experience and Practice S. E. Turvey I, B. Cronin l, A. D. Arnold 2, A, F. Dioun I , tDivision of Immunology, Children's Hospital, Boston, MA, 2Department of Pharmacy, Children's Hospital, Boston, MA.

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Heparin Desensitization in a Patient Requiring Cardiopul- monary Bypass for Aortic Valve Replacement (AVR) M. B. Strub, E. Brigino-Buenaventura, E R. Bocobo, D. E Ger- man, R. C. Richter, M. Ghotbi; Kaiser Permanente Medical Center, San Francisco and Vallejo, CA.

Successful Desensitization to Intravenous Cyelosporine: A Case Report H. M. Patel; Department of Medicine/Division of Allergy/ Immunology, SUNY-Stony Brook, Stony Brook, NY.

Anaphylactic Reaction to High Dose Methotrexate with Suc- cessful Desensitization S. McKnight, R. W. Fox, R. E. Crockett, R. E Lockey; University of South Florida College of Medicine and James A. Haley Veterans Medical Center, Tampa, FL.

Successful Desensitization to Oxaliplatin in a Patient with Oxaliplatin Hypersensitivity C. C. Lin, E M. Lobo; Internal Medicine, Section of Allergy & Immunology, Yale University School of Medicine, New Haven, CT.

Fresh Frozen Plasma (FFP) in the Treatment of Resistant ACE Inhibitor (ACE-I) Angioedema M. R. Warrier, C. A. Copilevitz, M. S. Dykewicz, R. G. Slavin; Allergy & Immunology, Saint Louis University, St. Louis, MO.

Cutaneous Adverse Drug Reaction to Pegylated Interferons During Peginterferon Alpha and Ribavirin Treatment for Chronic Hepatitis C T. Kinaciyan I , W. Jessner 2, E. Formann 2, B. Hayek 1, P. Steindl- Munda 2, P. Ferenci 2, G. Stingl2: 1Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Vienna General Hospital, Vienna, Aus- tria, Vienna, AUSTRIA, 2Division of Gastroenterology and Hepa- tology, Department of Internal Medicine IV, University of Vienna Medical School, Vienna General Hospital, Vienna, Austria, Vienna, AUSTRIA.

Cutaneous Reaction to Nadroparin: Clinical and Immunologi- cal Aspects S. E. Haine L, D. G. Ebo 2, V. M. Conraads I, A. Vorlat t, C. J. Vrints 1, W. J. Stevens2; ICardiology, University of Antwerp, Antwerpen, BELGIUM, 21mmunology-Allergology-Rheumatol- ogy, University of Antwerp, Antwerpen, BELGIUM.



Molecular and Cellular Mechanisms of Allergic Inflammation 8:45 884 The Chemokine Monokine Induced by IFN-g (Mig, CXCL9) is

a Potent Inhibitor of Eosinophils In Vitro and In Vivo P. C. Fulkerson I , N, Zimmermann 2, E. B. Brandt 2, E. E. Muntel 2, J. Kavanaugh 2, A. Mishra 2, Y. Ming 3, P. S. Foster 3, J. M. Farber 4, M. E. Rothenberg2; 1Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincin- nati, OH, 2Division of Allergy and Immunology, Cincinnati Chil- dren's Hospital Medical Center, Cincinnati, OH, 3Division of Bio- chemistry and Molecular Research, John Curtin School of Medical Research, Australian National University, Canberra, AUSTRALIA, 4Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Bethesda, MD.

J ALLERGY CLIN IMMUNOL Abst rac ts $399 VOLUME 111, NUMBER 2

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Toil-Like Receptor (TLR) Expression on Human Basophils: Evidence for Differential Modulation of IgE-Dependent and - Independent Cytokine Secretion with Specific Ligands J. T. Schroeder, K. Chichester, A. Bieneman; Medicine, Johns Hopkins University, Baltimore, MD.

Calcitonin Gene-Related Peptide (CGRP) Inhibits Antigen- Specific T-Cell Activation and Subsequent Development of a Primary Allergic Immune Response A, Dakhama, A. Balhorn, C. Taube, A. G. Alvarez, T. Kodama, N. Miyahara, A. Joetham, K. Takeda, E. W. Gelfand; Pediatrics, National Jewish Medical and Research Center, Denver, CO.

Augmentation of Allergic Inflammation by Cyclooxygenase (COX) Inhibition Does Not Depend on STAT6 Signaling R. S. Peebles, Jr. 1, K. Hashimoto 1, P. W. Jones I , J. D. Morrow 1, R. D. Collins j, K. Goleniewska I, J. Furlong ~, D. B. Mitchell I, B. S. Graham 2, J. R. Shellerl; Wanderbilt University School of Medi- cine, Nashville, TN, 2National Institutes of Health, Bethesda, MD.

The Role of IL-4, IL-13, and STAT6 in Experimental Intestinal Anaphylaxis T.A, Scribner I, E. B. Brandt I, R. T. Strait 2, E. MunteP, A. N. J. McKenzie 3, F. D. Finkelman 4, M. E. Rothenbergl; IAllergy/ Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Emergency Medicine, Cincinnati Children's Hos- pital Medical Center, Cincinnati, OH, 3MRC Laboratory of Mole- cular Biology, Cambridge, UNITED KINGDOM, 4Immunology, University of Cincinnati, Cincinnati, OH.

Expression of TGF-[3 and IL-10 in Patients with Allergic Eosinophilic Gastroenteritis and Esophagitis M. Chehade I, L. Qin 2, M. Magid 2, R. Castro 1, H. Sampson I, K. Beyerl; IPediatrics, Mount Sinai School of Medicine, New York, NY, 2pathology, Mount Sinai School of Medicine, New York, NY.

Phosphoproteomic Analyses of Upper Airway Mucosa Reveal Activation of Select Signaling Pathways in Patients with Aller- gic Rhinitis P, Leonard I, S. Stafford 1, K. Calhoun 2, E. Buckingham 2, M. Decherd 2, J. A. Grant I , S. Sur 1, R. Alam]; qnternal Medicine, Uni- versity of Texas Medical Branch, Galveston, TX, 2Otolaryngology, University of Texas Medical Branch, Galveston, TX.

The Involvement of Arginase and the Cationic Amino Acid Transporter 2 in Asthma Pathogenesis N. Zimmermann I, N. King I , M. Yang 2, A. Mishra i, S. M. PopO, C. L. MacLeod 3, Q. Hamid 4, P. S. Foster 2, M. E. Rothenbergl; IAllergy and Immunology, Children's Hospital, Cincinnati, OH, 2John Curtin School of Medical Research, Canberra, AUS- TRALIA, 3University of California, San Diego, CA, 4Meakins- Christie Laboratories, Montreal, PQ, CANADA.


Tuesday, March 11 11:00 AM to 12:00 PM

Respiratory Diseases Other Than Asthma 892 Allergic Diseases in Relation to Vaccinations and Infectious

Diseases: Two Cross-Sectional Studies in Schoolchildren 4 Years Apart R. Pierdomenico l, C. D'Ambrosio 2, G. Rasi 2, G. Lapucci 2, A. Torre 2, P. M. Matricardi 2, A. Carlucci 2, S. Bonini2; IASL-API3, Ascoli Piceno, ITALY, 21nstitute of Neurobiology and Molecular Medicine, National Research Council, Rome, ITALY.

893 Viral-Induced Respiratory Symptoms as Predictors of Con- comitant Wheezing C. C. Copenhaver, R. Gangnon, Z. Li, K. Roberg, K. Car]son- Dakes, P. Shult, C. Kirk, J. E. Gem, R. F. Lemanske, Jr.; Universi- ty of Wisconsin-Madison, Madison, WI.

894 Adenocarcinoma of the Lung in a Patient with Allergic Rhini- tis Presenting as Hoarseness and Sinusitis M. T. Nguyen, D. B. Moyer; Allergy, Kaiser Oakland Medical Center, Oakland, CA.

895 Negative Sweat Chloride Tests in Patients with Mutations of the Cystic Fibrosis Gene V. C. Gowda, M. Roberts, R. Wolfe, S. Gupta, P. Muniyappa, W. B. Klaustermeyer; Allergy and Immunology, West L.A. VAMC, Los Angeles, CA.

896 A Case Report: Bridging Bronchus with Severe and Recurrent Wheeze K. Miura, Y. Odajima, Y. Iikura; Department of Pediatrics, Showa University School of Medicine, Tokyo, JAPAN.

897 Successful Treatment of Cburg-Strauss Syndrome with Mycophenolate Mofetil M. Leva ] , P. DignettP. E. Rossi 2, L. Viassolo I , A. Zolezzi I , G. Pas- salacqua j, R. Quaglia I, G. W. Canonicat; 1Dept of Internal Medicine, Genoa University Allergy & Resp. Diseases, Genoa, ITALY, 2Dept of Internal Medicine, Haematology Dept, Genoa University, ITALY.

898 Increased Sensitivity to IL-4 in Cystic Fibrosis Patients with Allergic Bronchopulmonary Aspergillosis J. Smick I , M. Warrier l, "4. P. Kurup 2, P. S. Hutchinson I , A. P. Knut- senl; 1Allergy/Immunology, St. Louis University, St. Louis, MO, 2Allergy/hnmunology, Medical College of Wisconsin, Milwaukee, WI.

899 Correlation of Serum Precipitins and lgG Anti Aspergillus Fumigatus (IgG-Af) Determined by Fluoroenzymeimmunoassay P. S. Hutcheson, R. G. Slavin; Internal Medicine, Saint Louis Uni- versity School of Medicine, St. Louis, MO.

900 Pituitary Macroadenoma Presenting with Rhinitis A. L. Darte#, D. A. Khan2; IAllergy & Immunology, UTSouth- western, Dallas, TX, 2Allergy & Immunology, UT Southwestern, Dallas, TX.

901 Faecal Microflora in Atopic Wheezy and Non-Atopic Non- Wheezy Children M. A. Simon 1. C. S. Murray 2, G. W. Tannock I, H. J. M. Harmsen 3, G. W. Welling 3, A. Custovic 2, A. Woodcock2; ]Department of Microbiology, University of Otago, Otago, NEW ZEALAND, 2North West Lung Centre. Manchester, UNITED KINGDOM, 3Department of Medical Microbiology, University of Groningen, Groningen, NETHERLANDS.

902 Respiratory Syncytial Virus (RSV) Stimulation of Interleukin- 11 in Human Alveolar Epithelial Cells--Inhibition by Mon- telukast B. T. Leyko, J. Zimmennann, H. Shah, G. Joseph, Y. Huang, M. Frieri; Nassau University Medical Center, East Meadow, NY.

903 Antibiotic Use During Early Infancy Increases the Risk for Atopy C. Cole Johnson I, D. R. Ownby 2, S. L. Havstad 3, S. Hensley Alford 1, E. M. Zoratti 4, E. L. Peterson 3, C. L. M. Joseph3; ICancer Epidemiology, Prevention and Control, Henry Ford Health System, Detroit, MI, 2Allergy/Immunology, Medical College of Georgia, Augusta, GA, 3Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, 4Allergy/Immunology, Henry Ford Health System, Detroit, MI.

904 Chronic Cough and Vocal Cord Dysfunction (VCD) Relatedto Chronic Rhinitis and not Gastroesophageal Reflux (GER), but due to Inlet Patch (IP) of Acid Secreting Heterotopic Gastric Mucosa Below the Upper Esophageal Sphincter (UES) W. S. Silvers t,2, J. S. Levine 3, R. W. Weber4; IAllergy, Asthma, & Immunology Clinic of Colorado, Englewood, CO, 2University of

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Colorado School of Medicine, Denver, CO, 3Division of Gastroen- terology, University of Colorado School of Medicine, Denver, CO, 4National Jewish Medical & Research Center, Denver, CO.

905 Ten-year Diagnostic Experience with Primary Ciliary Dyskine- sia Using the Rhinoprobe in an Allergy/Immunology Practice J. E. Welch, M. B. Hogan, N. W. Wilson; Pediatrics, West Virginia University School of Medicine, Morgantown, WV.

906 Radiological Presentat ion of Pulmonary Eosinophilia (PE) Masquerade Pulmonary Tuberculosis (PT), Pneumonia (P), Pulmonary Infarction (PI), Ca. Lung (CL), Posing Diagnostic Difficulties E Khan I, M. [shaq2; IAllergy, Immunology, A1-Junaid Hospital. Nowshera Cantt NWFE PAKISTAN, 2Allergy, Immunology, Now- shera Cantt NWFP, PAKISTAN.

907 Chest Physiotherapy in Pediatric As thma--A Survey of Gener- al Pediatricians W. H, Hwan, E. Yousef, S. J. McGeady; Division of Allergy and Clinical Immunology, A. I. duPont Hospital for Children/Thomas Jefferson University, Wilmington, DE.

908 Allergic Asthma in Pulmonary Tuberculosis (TB) E. E. Fouda; AI-Azhar University Center for Immunology & Allergic Diseases, A1-Azhar University, Cairo, EGYPT.

909 Change of Serum Female Hormone Level and Airway Peak Expiration Flow in Menstruation-related Asthma Patients C. Ren I, Y. Gao2; IOb/gyn, 3rd Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan450052, CHINA, 21 st Affilated Hos- pital of Zhengzhou University, Zhengzhou, CHlNA.

910 Picornavirus is the Dominating Virus in Exacerbations in Tod- dlers with Recurrent Wheeze C. Ward I, J. Reid 2, R. Ratcheva 3, P. Banovcin 4, P. Davies 5, L. Willits 5, H. Bisgaard6; IGlaxoSmithKline, Stevenage, UNITED KINGDOM, 2Dunedin After Hours, Dunedin, NEW ZEALAND, 3Medical University Clinical Centre of Allergology, Sofia, BUL- GARIA, 4Faculty Hospital Pediatric Clinic, Martin, SLOVAK1A, 5GlaxoSmithKline, Uxbridge, UNITED KINGDOM, 6Copen- hagen University Hospital, Copenhagen, DENMARK.

911 Unusual Cause of Wheezing in an Elderly Female M. R. Reyes, P. J. Daffern; Allergy and Immunology, Virginia Commonwealth University, Richmond, VA.

912 Spontaneous Resolution of Eosiuophilic Granuloma with Peripheral Eosinophilia Following Staphylococcal Bacteremia S. J. KuhlJ,2; IAllergy and Infectious Diseases, Sacramento VA Medical Center, Mather, CA, 2Rheumatology, Allergy and Clinical Immunology, UC Davis, Davis, CA.

913 Heterogeneous Presentation of Obstructive Sleep Apnea Syn- dromes in Patients with Inflammatory Airway Disorders S. Fitzgerald I, C. Lowe 2, S. Lee I , M. Girish t, G. Krishnaswamy L B. Guhal; qnternal Medicine, Quillen College of Medicine and East Tennessee State University, Johnson City, TN, 2pediatrics, Quillen College of Medicine and East Tennessee State University, Johnson City, TN.

914 Pulmonary Function and Asthma Symptom Scores Following BCG Administration in Esiablished Asthmatics R. J. J. Hopp ], R. G. Townley 2, R. Sueiro 3, T. Romer03; IPedi- atrics, Creighton University, Omaha, NE, 2Medicine, Creighton University, Omaha, NE, 3Creighton University, Omaha, NE.



Asthma Mechanisms 915 RasGRP4 Controls Prostaglandin D2 (PGD2) Expression in

Human Mast Cells (MCs) R. L. Stevens, L. Li, Y. Yang; Medicine, Brigham and Women's Hospital, Boston, MA.

916 Role of Complement Receptor-Related Gene y (Crry)-Ig in Allergic Airway Inflammation and Hyperresponsiveness Y. Rha I, C. Taube 1, A. Joetham I , A. Dakhama 1, K. Takeda I, M. V. Holers 2, E. W. Gelfandi; I pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Medicine, University of Colorado Health Sciences Center, Denver, CO.

917 Eosinophil Cationic Protein (ECP) and Interleukin (IL)-8 Lev- els in Bronchoalveolar Lavage (BAL) from Pediatric Patients with Acute Asthma and Acute Bronehiolitis C. K. Kim 1,2, S. W. Kim ], Y. K. Kim I. H. Kita 2, Y. Y. Koh3; qnje University Sanggye Paik Hospital, Seoul, REPUBLIC OF KOREA, 2Mayo Clinic, Rochester, MN, 3Seoul National Universi- ty Hospital, Seoul, REPUBLIC OF KOREA.

918 Bradykinin Increases the in Vivo Expression of the C-X-C Chemokine Receptors CXCRI and CXCR2 in Allergic Rhinitis Subjects S. C. Christiansen I, J. Eddleston 2, G. R. Jenkins 2, J. A. Koziol 2, B. L. Zuraw2; 1Department of Allergy, Southern California Kaiser Permanente Medical Group, San Diego, CA, 2Molecular & Exper- imental Medicine, The Scripps Research Institute, La Jolla, CA.

919 The Effect of a Rhinovirus (RV) 16 Infection on Interferon (IFN)-g/Interleukin (IL)-5 Generation in the Airway W. W. Busse, R. E Vrtis, K. A. Schwantes, J. E. Gem; Medicine, University of Wisconsin, Madison. WI.

920 Identification of a Novel Metalloproteinase ADAM-8 in the Pathophysiology of Experimental Asthma N. E. King, N. Zimmermann, S. M. Pope, A. Mishra, D. P. Witte, M. E. Rothenberg; Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

921 Differential T-bet and STAT4 Expression in NK Cell Subpopu- lations with Disparate Capacities for IFN-gamma Production L. A. Rosenthal ], L. D. Mikus I , R. L. Sorkness t.2, R. F. Lemanske, Jr.]; J University of Wisconsin Medical School, Madison, Wl, 2Uni- versity of Wisconsin School of Pharmacy, Madison, Wl.

922 Modulation of Eosinophilia and Cytokines of Bronchoalveolar Lavage Fluid (BALF) by CpG ODN in a Mouse Model of Established Airway Inflammation S. Choi I , Z. Peng2; I Department of Pediatrics, Dongguk University, Kyung-ju, REPUBLIC OF KOREA, 2Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, CANADA.

923 Rhinovirus (RV)-Induced Interferon Gamma (IFNT) Secretion in Peripheral Blood Mononuclear Cells (PBMCs) Is Not Dependent on IL-12 G. D. Brooks], R. A. Brockman Schneider 2, A. G. Mosser I , W. W. Busse ], J. E. Gern2; IMedicine, University of Wisconsin, Madison, WI, 2pediatrics, University of Wisconsin, Madison, WI.

924 Effects of Inflammatory Cytokines on Hyaluronan (HA) Syn- thesis by Human Lung Fibroblasts (LF) and Arterial Smooth Muscle Cells (ASMC) L. C. Altman l, T. S. Wilkinson 2, S. Potter-Perigo 2, T. N. Wight2; I Allergy and Infectious Disease, University of Washington, Seattle, WA, 2Department of Vascular Biology, Hope Heart Institute, Seat- tle, WA.

925 CysLT1 Receptor Upregulation by TGF-beta and IL-13, but not IL-4, is Associated with Bronchial Smooth Muscle Cell Pro- liferation in Response to LTD4 M. Rola-Pleszczynski, K. Espinosa. J. Stankova: Allergy & Immunology, Fac Medicine, U Sherbrooke, Sherbrooke, PQ, CANADA.

926 The Major Mucin Producing Gene in the Airways, MUC-SAC, Positively Correlates with Airway Hyperreactivity in a Sensi- tized Murine Model of Asthma E J. Busse k, X. Li 2, C. Huang 2, K. Srivastava 2, M. Domaradzki 2, H. A. Sampson2; ~Department of Clinical Immunology, Mount Sinai School of Medicine, New York, NY, 2Department of Pediatric Allergy and Clinical Imnmnology, Mount Sinai School of Medi- cine, New York, NY.

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927 Bronchial Fibroblasts from Asthmatic Patients Have Impaired Biosynthesis of PGE2 Under Inflammatory Condition M. Pierzchalska, Z. Szabo, J. Soja, M. Sanak, A. Szczeklik; Medi- cine, Jagellonian University School of Medicine, Cracow, POLAND.

928 Increased Interleukin-13 (IL-13) Concentrations in Nasopha- ryngeal Secretion in Children with Allergic Asthma W. Feleszko I, A. Zawadzka-Krajewska ], K, Matysiak 2, D. Lewandowska 2, M. Kulus I; l Dept. of Pediatric Pneumonology and Allergy, The Medical University of Warsaw, Warszawa, POLAND, 2Anaestesiology Unit, The Medical University Children's Hospital, Warszawa, POLAND.

929 Activation of Voltage-gated Chloride Channels by Cytokines in Human Blood Monocytes M. Kim I, D, K. Agrawal2; rBiomedical Sciences, Creighton Uni- versity School of Medicine, Omaha, NE, 2Center for Allergy, Asth- ma and Immunology, Creighton University School of Medicine, Omaha, NE.

930 V~'4+ T-Cell Depletion During Exposure to Aeroallergen Increases Airway Responsiveness and Th2 Cytokine-Producing Pulmonary T Lymphocytes in Allergen Sensitized Mice Yo Hahn ~, C. Taube 2, K. Takeda 2, J. Park 2, N. Jin j, K. Aydintug~, J. M. Wands ~, M, Lahn ~, R. L. O'Brien I, E. W. Gelfand 2, W. K. Born i; l Immunology, National Jewish Medical and Research Cen- ter, Denver, CO, 2pediatrics, National Jewish Medical and Research Center, Denver, CO.

931 Effect of FLT3-Ligand Treatment on BALF of Ova Sensitized and Challenged Mice J. H. Edwan j, D. K. Agrawal2; IDepartment of Medical Microbi- ology and Immunology, Creighton University School of Medicine, Omaha, NE, 2Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE.

932 RSV G Glycoprotein is a Selective Th 2 Chemoattractant V. Wellemans, F, Bellessort, B. Lamkhioued; lmmunologie et Pathologic Respiratoires, Universit6 de Montr6al, Montr6al, PQ, CANADA.

933 Chemokine Receptors as RSV Receptors: Roles in Viral Entry and Immunopathology of the Lung F. Bellessort, V. Wellemans, B. Lamkhioued; Immunologic et Pathologic Respiratoires, Universit6 de Montr6al, Montr6al, PQ, CANADA. Suplatast Tosilate (ST) Inhibits Thymus- and Activation-Regu- lated Chemokine (TARC) Production by Antigen-Specific Human T Helper 2 (Th2) Cells N. Oda 1,2, K. Minoguchi I, A. Tanaka I, T. Yokoe L H. Matsuo I, S. K. Huang 2, M. Adachil; i Showa University, Tokyo, JAPAN, 2Johns Hopkins University, Baltimore, MD.

935 Decrease of Ex Vivo Expression of Costimulatiou Molecules During Virus-Induced Asthma Exacerbations in Peripheral Blood Mononuclear Cells of Atopic Asthmatic Children A. Bossios, N. G. Papadopoulos, M. Xatzipsalti, E. Manousakis, E Psarros, D. Gourgiotis, A. Constantopoulos, P. Saxoni-Papageor- giou; Research Laboratories, Allergy Unit, 2nd Dpt Pediatrics, Athens University, Goudi, GREECE.

936 RSV-Infection Induced Enhancement of Airway Hyperrespon- siveness in Allergen Sensitized and Challenged Mice Can Be Prevented by Inhibition of IL-13 J. Park I, C. Taube I, E. Yang I , A. Joetham j, A. Balhorn I, K. Take- da I, N. Miyahara 1, A. Dakhama i, D. Donaldson 2, E. W. GelfandJ; Z Pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Wyeth Genetics Institute, Cambridge, MA.

937 The 4G/5G Polymorphism in the Plasminogen Activator Inhibitor-1 Gene is Associated with Chronic Obstructive Pul- monary Disease L. T. Do I, S. H. Cho j, R. E Alban ~, R. Casaburi 2, C. K. OhJ; ]Pedi- atrics, Harbor-UCLA Medical Center, Torrance, CA. 2Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA.

938 Polymorphisms in the ADAM19 Gene are Associated with Asthma Susceptibility and Severity of Hyperresponsiveness in a Dutch Asthma Population D, A. Meyers I , T. D. Howard I , H. Jongepier 2, E. J. Ampleford I, E. R. Bleecker ], D. S. Postma2; ICenter for Human Genomics, Wake Forest Univ Sch of Med, Winston-Salem, NC, 2University Hospi- tal, Groningen, NETHERLANDS.

939 Association of the Arginine-16 Polymorphism Desensitization and 13z-Agonist Intrinsic Efficacy B. J. Lipworth I, D. K. C. Lee 1, G. P. Currie ], I. P. Hall 2, J. J. Lima3; ]Asthma and Allergy Research Group, Dundee, UNITED KINGDOM, 2University Hospital of Nottingham, Nottingham, UNITED KINGDOM, 3Nemours Children Clinic, Jacksonville, FL.

940 ICAM-1 Positive Nasal Epithelial Cells, Nasal Eosinophils, and D. Pteronyssinus Allergen Nasal Provocation in House Dust Mite-Sensitive Allergic Rhinitis: A Clinical Correlation Study J. Klaewsongkram I, K. Ruxrungtham l, P. Wannakrairot 2, P. Ruangvejvorachai 2, IF'. Phanupakl; J Department of Medicine, Fac- ulty of Medicine, Chulalongkorn University, Bangkok, THAI- LAND, 2Department of Pathology, Faculty of Medicine, Chula- longkorn University, Bangkok, THAILAND.

941 Gene Expression Profiles in the Nasal Mucosa of Allergic Rhiuitis Patients with Nasal Polyps S. B. Fritz 1, J. E. Terrell 2, E. R. Conner I, J. Kukowska-Latallo I, J. R. Bakert; ]Center for Biologic Nanotechnology, Division of Aller- gy and Clinical Immunology, The University of Michigan Medical Center, Ann Arbor, MI, 2Department of Otorhinolaryngology, The University of Michigan Medical Center. Ann Arbor, MI.

942 Role of Bone Marrow T Cells in Eosinophil Production Associ- ated with Asthma M. B. Hogan I, D. N. Weissman 2, L. F. Gibson I, D. Piktel 3, J. Welch ], K. S. Landreth3; 1Pediatrics, West Virginia University, Morgantown, WV, 2NIOSH-HELD, Morgantown, WV, 3Microbi- ology/Immunology, West Virginia University, Morgantown, WV.

943 Role of Sensitized CD4+ T Cells in the Development and Main- tenance of Pulmonary Eosinophilia and Allergic Airway Hyperresponsiveness (AHR) Following Primary and Sec- ondary Airway Challenge A. Joetham, C. Taube, Z. Cui, K. Takeda, E. W. Gelfand; Pedi- atrics, National Jewish Medical and Research Center, Denver, CO.

944 Neurotropbin-3 Expression in Human Bronchoalveolar Lavage Fluid Cells after Segmental Allergen Provocation: Functional Relevance for the Inflammatory Response in Allergic Asthma C. Nassenstein ~, J. C. Virchow, Jr. 2, W. Luttmann 3. H. Renz 4, A. Braunl; ]Dpt. of Immunology and Allergology, Fraunhofer Insti- tute for Toxicology and Aerosol Research, Hannover, GERMANY, 2Dpt. of Pneumology, University Clinics, Rostock, GERMANY, 3Medical University Clinics, Dpt. of Pneumology, Freiburg, GER- MANY, 4Dpt. of Clinical Chemistry, University Clinics, Marburg, GERMANY.

945 Blood Eosinophil and Serum Eosinophil Cationic Protein as a Marker of Bronchial Hyperresponsiveness in Children with Suspected Asthma Y. Park 1, Y. Y. Koh2; iDept of Pediatrics, Wonkwang University Kunpo Medical Center, Kunpo City, Gyonggido, REPUBLIC OF KOREA, 2Dept of Pediatrics, Seoul National University College of Medicine, Seoul, REPUBLIC OF KOREA.

946 Allergen Decreased Intereferon Gamma Production in CD8+ T Cells, NK Cells, TNK Cells From Patients with Mild Persistent Allergic Asthma Y. J. Cho 1, S. H. Maeng 2, J. S, Lee 2, Y. H. Chang2; llnternal Med- icine, Ewha Womans Mokdong Hospital, Seoul, REPUBLIC OF KOREA, 2Internal Medicine, Ewha Womans Mokdong Hospital, Seoul, REPUBLIC OF KOREA.

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947 AntiRANKL Antibody Maintains Trabecular Bone Mineral Density and Increases Cortical Area in Ovariectomized Swiss- Webster Mice: A New Therapy to Counteract Glucocorticoid- Induced Osteoporosis N. A. McHugh I, H. M. Vercesi 1, C. Crain 2, A. O'Garra 2, R. W. Egan~; IAllergy, Schering-Plough Research Institute, Kenilworth, N J, 2DNAX, Palo Alto, CA.

948 Assessment of Eosnophils and Eosinophil Cationic Protein in Induced Sputum in Childhood Asthma H. YoonL W. Kim2; Ipediatrics, Hallym University College of Medicine, Seoul, REPUBLIC OF KOREA, 2pediatrics, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA.

949 Expression of Stem Cell Factor in Epithelial Ceils and Number of Mast Cells in Nasal Polyps are Associated with Patients' Clinical Phenotypes M. L. Kowalski 1, A. Lewandowska l, R. Pawliczak I, J. Wozniak I , A. Ptasinska I, A. Jankowski 2, T. Kornatowski 2, M. Wagrowska- Danilewicz 2, M. Danilewicz2; IDepartment of Clinical Immunolo- gy and Allergy, Medical University, Lodz, POLAND, 2Medical University, Lodz, POLAND.

950 The Effect of Budesonide in Murine Asthma is Mediated by the Activation of Membrane and lntracei lular Glucocorticoid Receptors K. S, KondurP, S. D. Nandedkar 1, B. Gametchu2; IPediatrics, Medical College of Wisconsin, Milwaukee, WI, 2Pediatrics/Hema- tology-Oncology, Medical College of Wisconsin, Milwaukee, WI.

951 Localization of Nerve Growth Factor (NGF) Receptors in the Human Nasal Mucosa X. Wu, A. C. Myers, A. Goldstone, A. Ibgias, A. M. Sanico; Johns Hopkins University, Baltimore, MD.

952 Real-Time PCR Assays for the Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae on Throat Swabs J. D. Hester, B. S. Brede, J. E Halsey; ProGene Biomedical-lBT Reference Laboratory, Lenexa, KS.

953 IP- 10 Expression is Induced by Human Airway Epithelial Cells (HAE) in Response to Stimulation with Human Rhinovirus-16 (HRV-16) J. C. L. Spurrell, S. Wiehler, J. L. Pitchko, D. Proud; Physiology and Biophysics, University of Calgary, Calgary, AB, CANADA.

954 Detection and Quantitation of C16 and C18 Fatty Acid Acyl Conjugates of Triamcinolone Acetonide (TAA) in Airway Epithelial Cells using Gas Chromatography-Mass Spectrometry R. P. Schleimer, A. E. Blum, C. A. Bickel, N. M. Heller, W. C. Hubbard; Medicine, Johns Hopkins University, Baltimore, MD.

955 Inhibition of IL-4 Production in a Rat Mast Cell Line by Anti- sense Technology S. E Khurrum l, Z. Wu 2, D. B. G. Oliveira ?-, L, J. Hammond r, R. M Mirakian I, P. A. Birol; IDepartment of Immunology, Queen Mary, University of London, London, UNITED KINGDOM, 2Renal Medicine, St. George's Hospital Medical School, London, UNITED KINGDOM.

956 Alterations of Cytokine Profiles in Allergic Asthma Patients V, N, Tsybulkina, O. V. Skorochodkina, A, P. Tsybulkin; Kazan State Medical University, Kazan, RUSSIAN FEDERATION.

957 Is the Increase in CD30 Expression a Cause or Consequence of Apoptosis in Human Blood Ensinophils? A. I. Berro, D. K. Agrawal; Center for Allergy, Asthma, and Immunology, Creighton University School of Medicine, Omaha, NE.

958 The Importance of Sputum Eosinophilia in Patients with Cough Variant Asthma in the Prediction of Subsequent Devel- opment of Classic Asthma Y. Y. Koh, H. Kang, E. K. Kang; Seoul National University Hos- pital, Seoul, REPUBLIC OF KOREA.

959 Production of Cysteinyl-Leukotrienes by Airway Epithelial Cells in Response to Acidic Stress in vitro S. Horn t, J. VaughaM, A. Nguyen I, T. A. E. Platts-Mills 2, J. Hun0; I Division of Pediatric Respiratory Medicine, University'of Vir-

ginia, Charlottesville, VA, "Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA.

960 ln te r leukin- lb and In ter lenkin- l ra Increase in Late Phase Response to Segmental Allergen Challenge in Asthmatics Unal- tered by Beclomethasone and Salmeterol D. J. Amrol, D. H. Hagaman, J. L. Morgan, J. J. Murray; Vander- hilt University, Nashville, TN.

961 Serum Total lgE and Specific lgE to D. Pteronyssinus, but not Eosinophilic Cationic Protein (ECP), Are More Likely to be Elevated in Elderly Asthmatics M. J. King ].2, S. Bukantz 3, S. Phillips 2, S. S. Mohapatra 3, T. S. Randa]I 3, R, E Lockey3; 1Allergy and Immunology, University of South Florida College of Medicine and Veteran's Hospital, Tampa, FL, 2Morton Plant Hospital, Clearwater, FL, 3University of South Florida College of Medicine, Tampa, FL.

962 Intranasal Atrial Natriuretic Peptide (ANP) Gene Transfer Atten- uates Airway Reactivity in a Mouse Model of Allergic Asthma S. S. Mohapatra ], M. Kumar 2. A. Behera 2, G. Hellerman 2, R. F. Lockey 2, D. Vesely2; qnternal Medicine (MDC- 19), Univ of South Florida Coil of Med & JAH VA Hosp, Tampa, FL, 2Univ of South Florida Coil of Med & JAH VA Hosp, Tampa, FL.

963 Immune Stimulatory DNA in Farm Barn Dust S. R, Roy L2, A. M. Schlitz J, Y. Shen I, A. H. Liul,2; ]Pediatric Allergy & Clinical Immunology. National Jewish Medical & Research Center, Denver, CO, 2University of Colorado Health Sci- ences Center, Denver, CO.

964 A 3-ram Wheal Doesn't Discriminate Between Cat Allergic and Non-Allergic Patients C. F. Remer. M, S. Kaplan, B. J. Goldberg, A. M. Staveren, C. K. Lin; Department of Allergy/Clinical Immunology, Sunset Kaiser Permanente, Los Angeles, CA.

965 Increasing Prevalence of Allergic Diseases Among Thai Chil- dren: The ISAAC III Results P. Vichyanond I. S. Kaewsomboon 2, S. Ruangrak 2, N. Visitsun- thorn 2, V. Cherdjirapong 2, G. Pongsamart 2, T. Simasathien2; IDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, THAILAND, 2Department of Pedi- atrics, Faculty of Medicine Siriraj Hospital, Bangkok, THAILAND.

966 Effect of Systemic or Local Eotaxin Neutralization on Allergen- Induced Eosinophilic Inflammation M. Rhdinger; Dept. of Resp. Med and Allergol. Internal Medicine, Giiteborg, SWEDEN.

967 Urban House Dust DNA Suppresses TNF-ot Production In Vitro A. Marotta I,-~, A, M. Schlitz ] , S. R. Roy 1,2, A. H. Liul,2; IPediatric Allergy & Clinical Immunology, National Jewish Medical and Research Center, Denver, CO, 2University of Colorado Health Sci- ences Center, Denver. CO.

968 The Effect of Maternal Egg Avoidance on Atopy at Eighteen Months K. E. C. Grimshaw, G. H, S. Vance, R. A. Briggs, J. O. Warner; School of Medicine, University of Southampton. Southampton, UNITED KINGDOM.

969 Immune Tolerance Induced by the House Dust Mite/Cholera Toxin B Conjugate C. Lee; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea, REPUBLIC OF KOREA.

970 Pulmonary Function Studies in Healthy American-Born Chil- dren of Filipino Descent Residing in Hawaii J. C. Kam I, E. M. Watanabe 2, E E. Lurie2; IDepartment of Aller- gy/Immunology, Straub Clinic & Hospital. Honolulu, HI, 2Straub Foundation, Honolulu. HI.

971 Relationship of Serum lnterleukin-13 with Eotaxin and Airway Hyperresponsiveness in Atopic Asthmatics J. Yang, J. Shim, D. Keum; Pediatrics, Kangbuk Samsung Hospi- tal, Seoul, REPUBLIC OF KOREA.

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9"12 Neutrophil Activation in Moderate-to-Severe Asthmatics Com- pared with Controls L. Dziadzio I , M. Lokuta 2, A. Bhattacharya t , W. W. Busse t , A. Hut- tenlocher2; J Dept. of Medicine, University of Wisconsin, Madison, WI, 2Dept. of Pediatrics, University of Wisconsin, Madison, WI.

9"g3 Correlation between Inhalant Allergen-Specific IgE and Pul- monary Function in Asthmatic Patients S. Y, Cboil, M. H. Sohn 1, H. Y. Yum 2, K. E. Kim J; J Department of Pediatrics, Yonsei University College of Medicine, Seoul, REPUB- LIC OF KOREA, 2Department of Pediatrics, Pochon CHA Uni- versity College of Medicine, Seoul, REPUBLIC OF KOREA.

974 Analysis of IgE levels in Pediatric Allergy in South Africa and the USA M. Ellaurie I, G. Hu 2, N. L. Pillay3; tDepartment of Medicine, Pennsylvania State University, Hershey Medical Center, Hershey, PA, 2psu, Hershey, PA, 3St. Augustine's Hospital, Durban, SOUTH AFRICA.

975 The Role of Cytokines in Bronchial Asthma (BA) R. I. Sepiashvili; Allergology, National Institute of Allergology, Asthma @Clinical Immunology, Moscow, RUSSIAN FEDERA- TION.

976 Thl /Th2 T Cells and Cytokine Synthesis in Cystic Fibrosis Patients with Allergic Bronchopulmonary Aspergillnsis A. P. Knutsen I , P. Hutchinson l, J. Smick I , V. P. Kurup2; IAllergy and Immunology, St. Louis University, St. Louis, MO, 2Allergy and Immunology, Medical College of Wisconsin, Milwaukee, WI.

Poster Session 55o3


Genetics and Epidemiology of Asthma 977 Analysis of IgE Heavy Chain V-gene Usage in Human Tonsil

W. J. J. Finlay, R. L. Rabin, J. E. Slater; Center for Biologics Eval- uation and Research, US Food and Drug Administration, Bethesda, MD.

978 The Influence of HLA Alleles on Graft Loss and Rejection Episodes in Renal Transplantation G. Vitalpur j, S. Dixi0, J. Boudreaux 2, D. Frey 2, B. Arora I, K. Wiley ], D. Mercante 3, P. Kumarl; 1Medicine/Allergy, LSU Med- ical Center, New Orleans, LA, 2Transplant Institute of New Orleans, New Orleans, LA, 3School of Dentistry, LSU Medical Center, New Orleans, LA.

979 IgE and IgG Antibody Responses to Cat and Dust Mite Aller- gen over the First Five Years: Influence of Maternal Immune Responses D. M. Riposo I, E. A. Erwin 1, N. J. Custis l, K. Blumenthal i, M. Barr 2, D. Sredl 2, H. A. Burge 3, D. R. Gold 2, T. A. E. Platts-Millsl; iUniv VA Asthma/Allergic Diseases Center, Charlottesville, VA, 2Channing LaboratorY, Brigham and Women's Hospital, Boston, MA, 3Harvard School of Public Health, Boston, MA.

980 Genome Search for Pollen Reactivity Loci: Genome Screen for Susceptibility Loci Contributing to Pollen Sensitivity in US Populations M. N. Biumenthal ], E. R. Bleecker 2, T. H. Beatty 3, C. Ober 4, S. Banks-Schlegel 5, S. S. Rich2; ~Allergy, University of Minnesota, Minneapolis, MN, 2Wake Forest University, Winston-Salem, NC, 3Johns Hopkins University, Baltimore, MD, 4University of Chica- go, Chicago, IL, 5NHLBI, Bethesda, MD.

981 A Novel Single Nucleotide Polymorphism in Complement Component 5 Receptor 1 (C5aR) on Chromosome 19q13.3 is not Associated with Asthma in an Afro-Caribbean Population M. Munoz 1, A. Zambelli-Weiner 2, E. Ehrlich 2, S. Jimenez ~ , L. Caraballo i, M. Wills-Karp 3, K. C. Barnes2; IUniversity of Carta-

gena, Cartagena, COLOMBIA, 2Johns Hopkins University, Balti- more, MD, 3University of Cincinnati, Cincinnati, OH.

982 A Genetic Association Study Between Asthma and CD14 Pro- moter Polymorphism in Chinese Children T. F. Leung i , N. L. S. Tang 2, Y. M. Sung 2, G. W. K. Wong i , C. W. K. Lam 2. A. M. Li i, I. H. S. Chart 2, T. E Fok i; ~ Pediatrics, The Chi- nese University of Hong Kong, Hong Kong SAR, CHINA, 2Chem- ical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, CHINA.

983 Physical Activity is Not Associated with Asthma in a Caucasian Isolate K. B. Held t, M. L. Stockton t, R. A. Mathias 2, K. C. Barnes1; iClinical Immunology, Johns Hopkins University, Baltimore, MD, 2Department of Epidemiology, Johns Hopkins University, Balti- more, MD.

984 Association of CDI4 Gene Promoter Polymorphisms with Atopic Phenotypes in Singapore Population L. Xiaohui I, C. Wai 2, H. Chew Kiat 2, W. De Yunl; IDepartment of Otoiaryngology, National University of Singapore, Singapore, SINGAPORE, 2Department of Pediatrics, National University of Singapore, Singapore, SINGAPORE.

985 Asthma and Associated Phenotypes in Puerto Rico's Asth- matics W. Hernandez l, M. N. Blumenthal2; JPonce University, Ponce, PUERTO RICO, 2University of Minnesota, Minneapolis, MN.

986 An Association Between Dandy-Walker Malformation and Nijmegen Breakage Syndrome in a 10-Year-Old Boy F. Gutin j, E. A. Secord2; t Allergyflmmunology, Wayne State Uni- versity/DMC/Children's Hospital of Michigan, Detroit, MI, 2Wayne State University/DMC/Children's Hospital of Michigan, Detroit, MI.

987 Prospective Dust Mite Sensitivity Study in a Taiwan Population C. Lin I, C. L. Liebeler 2, D. R. Jackola 2, A. Rosenberg 2, M. N. Blu- menthal2; tChanghua Christian Hospital, Changhua, TAIWAN REPUBLIC OF CHINA, 2University of Minnesota, Minneapolis, MN.

Poster Session 5504


Autoimmunity 988 A New Model of B Cell Superantigen Immune Complex Medi-

ated Inflammation R. A. Sporici, W. Li, A. Anderson, A. I. Levinson; Allergy & Immunology Section, University of Pennsylvania, Philadelphia, PA.

989 NPY Ameliorates Experimental Autoimmune Encephalitis (EAE): Y1 Receptor Specific Induction of a Th2 Shift in vivo S. Bedoui t, K. Miyamoto t, A. Beck-Sickinger 2, S. von Horsten 3, S. Miyake i, T. Yamamural; I Department of lmmunol *" " Institute of Neuroscience, NCNP, Tokyo, JAPAN, 2 Leipzig, Leipzig, GERMANY, 3Medical School Ha nover, GERMANY.

990 NKT Cells Can Exacerbate Ongoing Type 2 lmr Antigen-Specific Manner K. T. HayGlass, S. Haile; Immunology, University Winnipeg, MB, CANADA.

991 A Variant of Childhood-Onset Myasthenia Gray Typing and Clinical Characteristics in Japan N. Shinomiya t, Y. Nomura 2, M. Shinomiya 3, M. Se I atrics, Toho University School of Medicine, Oha Tokyo, JAPAN, 2Segawa Neurological Clinic for Chi JAPAN, 3Toshiba Hospital, Tokyo, JAPAN, 4Segawa Clinic for Children, Tokyo, JAPAN.

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992 Intravenously Applied IgG Stimulates Complement Attenua- tion in Dermatomyositis at the Amplifying C3 Convertase Level H, U. Lutz 1, P. Stammler j, V. Bianchi 1, R. M. Triieb 2. T. Hunzik- er 3, R, Burger 4, E. Jelezarova l, P. J. Sp~ithS; IDepartment of Biolo- gy, Institute of Biochemistry, Swiss Federal Institute of Technolo- gy, Zurich, SWITZERLAND, 2Department of Dermatology, University Hospital of Zurich, Zurich, SWITZERLAND, 3Depart- ment of Dermatology, Inselspital, Berne, SWITZERLAND, 4Robert Koch Institute, Berlin, GERMANY, 5ZLB Bioplasma Ltd, Berne, SWITZERLAND.

993 Inflammatory Mechanisms Involved in Familial Cold Autoin- flammatory Syndrome A. N. Greiner 1, J. L. Mueller 1, J. Nayar j, S. Rosengren ], A. A. Wanderer 2, H. M. Hoffman|; ~University of California San Diego, San Diego, CA, 2University of Colorado at Denver, Denver, CO.

004 Rituximab as Treatment for Giant Cell Hepatitis with Autoim- mune Hemolytic Anemia M. J. Palumbo, N. Taugsinmankong, R. A. Good; Allergy and Immunology, All Children's Hospital, Saint Petersburg, FL.

095 Circulating Dendritic Cell (DC) Subtypes in Rheumatoid Arthritis (RA): Influence of Anti-TNF-alpha Therapy A. J. Schuerwegh, M. M. Hagendorens, J. E Van Offel, D. G. Ebo, C. H. Bridts, W. J. Stevens, L. S. De Clerck; lmmanology-Aller- gology-Rheumatology, University of Antwerp, Antwerpen, BEL- GIUM.

906 Mononuclear Phagocytes (MP) in Rheumatoid Arthritis (RA): Discordance of Internalization and Digestion Functions A. P. Tsyhulkin, M, I. Arleevskaja, D. G. Khaliullina, A. I. Zabotin, V. N. Tsybulkina; Kazan State Medical Academy, Kazan, RUSSIAN FEDERATION.

997 Is Immunofluorescence Antineutrophil Cytoplasmic Antibod- ies (IF-ANCA) Test Ordered Appropriately by Clinicians? D. Zauli, A. Grassi, E. Manfredini, S. Zucchini, E B. Bianchi; Dept. of Internal Medicine, Cardioangiology, Hepatology, Univer- sity of Bologna, Bologna, ITALY.

998 Neural Stem Cell Cytotoxic Activity in Cerebrospinal Fluid from a Patient with End-Stage Neuropsychiatrie Systemic Lupus Erytbematosus M. M. Cyr I , B. Sakic 2, J. A. Denburgl; JMedicine, McMaster Uni- versity, Hamilton, ON, CANADA, 2psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, ON, CANADA.

999 Primary Autoimmune Neutropenia Associated with Endo- crinopathy M. A. Yacovone j, P. Powers 2, R. K. KatiaP; ]Allergy & Immunol- ogy, Walter Reed Army Medical Center, Washington, DC, 9-Pedi- atric Endocrinology, Walter Reed Army Medical Center, Washing- ton, DC.

1000 Positive Antinuclear Antibodies in a 15-Year-Old Girl with HAIR-AN Phenotype N. Mathur I , W. Bastian 2, M. Castro 3, H. J. Moallem l, R. Joks 4, A. S. Josephson4; 1Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY, 2Pediatric Endocrinology, SUNY Downstate Med- ical Center, Brooklyn, NY, 3Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 4Allergy/Immunology, SUNY Downstate Medical Center, Brooklyn, NY.

1001 In Acute/Subacute Guillain-Barre Syndrome (GBS) with Vul- nerable Cardiovascular System, Intravenous Immunoglobulin (IV IG), Safely Reduce Not Only the Intensity of Polyradicu- Ioneuropathy Also Its Morbidity and Mortality; Whereas in Chronic Cases ACTH and Physiotherapy Has Significantly Improved Life Style I. Muhammad I, S. Khan2; IAllergy, Immunology, AI-Junaid Hos- pital, Nowshera, PAKISTAN, 2Allergy, Immunology, Al-Junaid Hospital, AI-Junaid Hospital, PAKISTAN.

1002 Alternative Maturation Programs for Immature DCs That Determine Immunity vs Tolerance Decision D. Usharaul i ; Immunology, Biothechnology, Tbilisi, Tbilisi, GEORGIA.

1003 Role of IFN-beta Gene in the Immune Response after CpG Motifs Treatment in an Allergy Murine Model V. Matheu ~, A. Treschow I, I. Teige ~, Y. Barrios 2, S. Issazadeh- Navikasl; IMedical Inflammation Research, Lund University, Lund, SWEDEN, 21mmunology, HUC, Tenerife, SPAIN.

1004 Vitamin C as an Immunomodulatory Agent in Humans S, Y. Ritter, G. D. Marshall; Division of Allergy and Clinical Immunology, University of Texas Medical School at Houston, Houston, TX.

1005 Immunomodulation ofT cells by the Chinese Herbal Medicine Ling Zhi (Ganoderma lucidum) M. Wen I, A. Teper I, K. D. Srivastava i, C. Huang I, B. Schofield 2, X. Lil; 1Pediatrics, Mount Sinai School of Medicine, New York, NY, 2Department of Environmental Health Sciences, Johns Hop- kins University School of Hygiene and Public Health, Baltimore, MD.

1008 Thimerosal Causes Mitoehondrial Microenvironment Change in Neuronal Cells L. YeU, S. Gupta2; ]Medicine/Immunology, University of Calilor- nia, Irvine, CA, 2Medicine/Immunology, University of Calitbrnia, Irvine, CA.

100"7 Dietary N-3 Polyunsaturated Fatty Acid (PUFA) Supplementa- tion During Pregnancy is Associated with Changes in Cord Blood (CB) Progenitor Numbers and Responsiveness to IL-5 in Infants at Risk of Atopy H. M. Hatfield 1, J. A. Dunstan 2, L. Hayes j, R. Sehmi I, P. M. Holt 3, J. A. Denhurg [, S. L. Prescott2; IMcMaster University, Hamilton, ON. CANADA, 2University of Western Australia, Perth, AUSTRALIA, 3Telethon Institute for Child Health Research, Perth, AUSTRALIA.

1008 Liposome DNA Vaccination for Cockroach Allergy in Mice A. W. Y. James ], A, W. James I, A. Saeed e, J. Yang 3, C. F. Michael 2, X. Du 2, Y. Guo 2, Y. Park 2, U. Nair 2, S. Kanangat 2, I". J. Yoo2; IAllergy/lmmunology, University of Tennessee, Memphis, TN, 2Allergy/Immunology, Memphis, TN, 3Allergy/Immunology, Memphis, TN.

1009 Study of a Specific IgE Against Carbonic Anhydrase in a Fam- ily with Tubular Renal Acidosis J. C. Muifio I , L. 1. Juncos 2, N. Garcia 2, M. D. Romero-Piffeguer 3, M. Ferrero 3, D. Beltramo4; IAIlergy & Immunology Secci6n, Internal Medicine Service, Hospital Misericordia, C6rdoba, ARGENTINA, 2Clinical Departament of IPEM, IPEM, C6rdoba, ARGENTINA, 3Allergy & Immunology Secci6n, Internal Medi- cine Service, Hospital Misericordia, C6rdoba, ARGENTINA. 4Immunology Departament Ceprocor, Ceprocor, C6rdoba, ARGENTINA.

1010 Inhibition of Tonsil-Derived (T-D) B-Cell Apoptosis Permits the Expression of Disease-Specific (D-S), IgM Rheumatoid Factor (RF) Expression D. MilojeviO, V. R. Bonagura2; IDivision of Allergy and Immunology, Dept. of Pediatrics, Schneider Children's Hospital, LIJ Medical Center, New Hyde Park, NY, 2Division of Allergy and Immunology, Dept. of Pediatrics. Schneider Children's Hospital, LIJ Medical Center, New Hyde Park, NJ.

1011 Chondrocyte Apoptosis Induced in Vitro is Caspase-3-Mediat- ed, but is not Demonstrated in Cartilage from Patients with Rheumatoid Arthritis or Osteoarthritis J. E Van OffelL I. C. Koster I, G. J. Van Elsen I, A. J. Schuerwegh L C. H. Bridts l, M. M. Kockx 2, W. J. Stevens I, L. S. De Clerckl; llmmunology-Allergology-Rheumatology, University of Antwerp, Antwerpen, BELGIUM, 2Pathology, AZ Middelheim, Division of Pharmacology, University of Antwerp, Antwerpen, BELGIUM.

J ALLERGY CLIN IMMUNOL Abstracts S405 VOLUME 111, NUMBER 2

Poster Session 5505


New Insights for Dermatologic Diseases 1012 Expression of Soluble High-Affinity IgE Receptors and Its

Interferences with Type 1 Hypersensitivity Reactions S. Renshan; Department of Dermatology, Institute of Derma- tovenerology in Gaotanyan, Chongqing, CHINA.

1013 Hydroxyzine from Various Topical Phospholipid Liposomal Formulations: Evaluation of Peripheral Antihistaminic Activi- ty and Systemic Absorption in a Rabbit Model A. A. W, Elzainy 1, X. Gu I, E. R. Simons 2, K. J. Simonsl; 1Phar- macy, University of Manitoba, Winnipeg, MB, CANADA, 2Pedi- atrics, University of Manitoba, Winnipeg, MB, CANADA.

1014 Treatment of Keratodermam Hereditara Mutilans with Topical Tacrolimus: A Case Study with Histopathology Pre- and Post- Treatment M. A. Guanzon I, B. B. Faltay t, A. Ishida-Yamamoto 2, B. A. Sil- verman I, A. T. Schneiderl; IAllergy/Immunology, Long Island College Hospital, Brooklyn, NY, 2Department of Dermatology, Asahikawa Medical College, Asahikawa, JAPAN.

1015 Netherton Syndrome: Probably a Frequently Misdiagnosed Entity C. L. Hedberg j, D. J. Hogan 2, S. L. Bahnal; LDepartment of Pedi- atrics, Section of Allergy/Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, 2Department of Medicine, Section of Dermatology, Louisiana State University Health Sci- ences Center, Shreveport, LA.

1018 Relapsing Post-infectious Rash with Desquamation B. Mahboub l, P. Vadas2; IAllergy and Clinical immunology, Uni- versity of Toronto, Toronto, ON, CANADA, 2St. Michael's Hospi- tal, University of Toronto, Toronto, ON, CANADA.

1017 Angioedema--Not! Eosinophilic Faseiitis Presenting as Angioedema P. A. Barzaga I , B. Ryhal 2, P. Carroll3; IAllergy/Clinical Immunol- ogy, University of California Davis, Sacramento, CA, 2Allergy/Clinical Immunology, Kaiser Permanente, Roseville, CA, 3Rheumatology, Kaiser Permanente, Roseville, CA.

1018 Hereditary Angioedema in Three Brothers with Normal C1 Esterase Inhibitor Level and Function S. Gupta, E Wu, V. C. Gowda, P. Muniyappa, W. B. Klaustermey- er; Allergy/Immunology, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA.

1019 Hereditary Angioedema with Unusual Features M. I. Mabudian, G. Vitalpur, P. Kumar; LSUHSC, New Orleans, LA.

1020 Clinical Outcomes of Pregnant Women with Mastocytosis S. B. Bruns, K. Hartmann; Department of Dermatology, Univer- sity of Cologne, Cologne, GERMANY.

Poster Session 5506


Allergen Structure and Function 1021 Anaphylaxis after Hamster Bites--Identification of a Novel

Allergen D. L. Lira, H. P. Van Bever. R. Chan, K. Chua; Pediatrics, Nation- al University of Singapore, Singapore, SINGAPORE.

1022 Cloning and Immuno-Characterization of Complete Group 9 Allergens from 3 Major Dust Mites, Blomia tropicalis, Der- matophaoides farinae and Dermatophagoides pteronyssinus H. S. Shang ] , S. T. Ong 1. X. Z. Bi I, L. C. Tsai 2, S. H. Lim 1, E T.

Chew1; INational University of Singapore, Singapore, SINGA- PORE, 2Veterans General Hospital, Taipei, TAIWAN REPUBLIC OF CHINA.

1023 Association between Sensitization to Specific Dust Mites Aller- gens and Manifestation of Allergic Diseases in Four Different Populations A. C. Angus I, X. S. Wang 1, A. Marl 2, V. Mahakittikun 3, C. Bun- nag 3, P. Vichyanond 3, Y. S. Sew 4, H. Kulaveerasingam 4, S. H. Tan 4, S. C. Chua ], S. T. Wun I , S. T. Ong I, K. T. Kuay 1, W. L. Wang I , X. Z. Bi t, H. S. Shang t, E T. Chewl; INational University of Singa- pore, Singapore, SINGAPORE, 2National Health Service, Rome, ITALY, 3Mahidol University, Bangkok, THAILAND, 4putra Uni- versity Malaysia, Serdang, MALAYSIA.

1024 Ferret Allergy: Identification of Serum Specific IgE to Albumin with Crossreactivity to Cat J. S. Nugent, B. Whisman, L. L. Hagan: Allergy/Immunology, Wi]ford Hall Medical Center, Lackland AFB, TX.

1025 Molecular Cloning and Character izat ion of an Ovalbumin (Gal d 2) Homologue in House Dust Mite, Dermatophagoides farinae S. T. Ong l, A. C. Angus I, L. C. Tsai 2, S. H. Lira I, E T. Chew]; INational University of Singapore, Singapore, SINGAPORE, 2Vet- erans General Hospital, Taipei, TAIWAN REPUBLIC OF CHINA.

1026 Allergenic Characterization of Dusky Brown Cockroach, Peri- planeta fuliginosa Tropomyosin K. Jeong j, H. Hwang 2, J. Lee 1. I. Lee 3, D. Kim 2, C. Hong 4, H. Ree 3, T. Yong]; IDept. of Parasitology and Institute of Tropical Medicine, BK 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 2Dept. of Pediatrics, Yonsei University College of Medicine, Seoul, REPUB- LIC OF KOREA, 3Dept. of Parasitology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, REPUB- LIC OF KOREA, 4Dept. of Internal Medicine and Institute of Allergy, BK 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA.

1027 Production of Recombinant Apple and Peach LTP in Pichia Pastoris L. Zuidmeer 1, I. Rafalska I, N. Tellez-Besoli], N. Rigby 2, C. Mills 2, K. Hoffmann-Sommergruber 3, R. Van ReO; qmmuno- pathology, Sanquin, Amsterdam, NETHERLANDS, 2Norwich Research Park, Institute of Food Research, Norwich, UNITED KINGDOM, 3Department of Pathophysiology, University of Vien- na, Vienna, AUSTRIA.

1028 BIot 13 Allergen from Blomia tropicalis Shows High Frequen- cy of IgE Binding in Allergic Cuban Patients and Cross-reactivity with Dermatophagoides siboney Extract L. Puerta ) , A. Labrada 2, M. Labrada 2, K. Uyema 2, S. Jim6nez ] , L. Caraballot; qnstituto de lnvestigaciones Inmunol6gicas, Universi- dad de Cartagena, Cartagena, COLOMBIA, 2Department of Aller- gens, National Center of Bioproducts (BIOCEN), Havana, CUBA.

1020 Identification of Ubiquitin as a Low Molecular Weight Allergen of Blomia tropicalis (Bt) D. Mereado I, L. Boluda 2, L. Caraballo I, E. Fernandez-Caldas2; IUniversity of Cartagena, Cartagena, COLOMBIA, 2Leti Labora- tories, Madrid, SPAIN.

1030 Large Scale Screening of Putative Allergen Genes from Acarus siro Y. F, Gao, E T. Chew: National University of Singapore, Singa- pore, SINGAPORE.

1031 AIlergenicity of House Dust Mite Eggs L. G. Arlian, M. S. Morgan, N. Fall, S. Kahn, J. S. Neal, D. L. Vyszenski-Moher; Dept. of Biological Sciences, Wright State Uni- versity, Dayton, OH.

S406 A b s t r a c t s J ALLERGY CLIN IMMUNOL FEBRUARY 2003

1032 Epitope Analysis of Hey b 12, a Cross Reacting Latex Allergen D. H. Beezhold I , V. L. Hickey l, L. Zuidmeer 2, G. L. Sussman3; t Laboratory of Immunobiology, Guthrie Research Institute, Sayre, PA, 2C.L.B., Amsterdam, NETHERLANDS, 3University of Toron- to, Toronto, ON, CANADA.

1033 Livetins as Inhaled Allergens in the Bird-Egg Syndrome M. C. Garcia-Gonzdiez j, A. Garcla-Balda z, M. C. Dirguez-Pas- tor I . M. R. Gonzdlez-Mendiola I , P. Prieto-Montafio l, J. Carnrs 2, E. Fernandez-Caldas 2, B. Hoz-Caballeri; J Allergy, Hospital Ram6n y Cajal, Madrid, SPAIN, 2C.B.F. LETI, S.A., Madrid, SPAIN.

1034 Hevein-like Domain IV in Wheat Germ Agglutinin (WGA) is Responsible for the Majority of IgE Cross-reactivity between WGA and Hevein (Hey b 6.02) P. Karisola l, H. Alenius 2, K. Turjanmaa 3, T. Reunala 3, N. Kalkki- nen 4, T. Palosuo 5, M. Kulomaa6; ~Biological and Environmental Sciences, Molecular Biology, University of Jyvaskyla, Jyvaskyla, FINLAND, 2Finnish Institute of Occupational Health, Helsinki, FINLAND, 3Tampere University Hospital, Tampere, FINLAND, 4University of Helsinki, Helsinki, FINLAND, 5National Public Health Institute, Helsinki, FINLAND, 6University of Jyvaskyla, Jyvaskyla, FINLAND.

1035 Identification of Homologues to Manganese Superoxidase Dimutase, Thioredoxin, Cyclophilin, Profilin, a Calcium-Bind- ing Protein, and a Fibrinogen-Binding Protein as IgE Binding Components in Curvularia lunata 17. L, Wong, S. S. Joshi, B. W. Lee, T. K. Tan, F. T. Chew; Nation- al University of Singapore, Singapore, SINGAPORE.

1036 Immunoblot Analysis of the Sera of Patients Allergic to Rat in C6rdoba, Argentina A. M. Kahn ~, C. C. Castro ~, E. G. Wolff I, M. J. Gregorio I, M. Ordofiez I, M. D. Romero-Piffeguer I, D. Beltramo 2, J. C. MuifioJ; XAllergy & Immunology Secci6n, Internal Medicine Service, Hos- pital Misericordia, C6rdoba, ARGENTINA, 21mmunology Depar- tament, Ceprocor, C6rdoba, ARGENTINA.

1037 Isoprene Increases GST Production and Allergenic Activity in Alternaria Alternata J. Shankar ~, S. Sridhara 2, B. P. Singh 2, N. Arora2; IAllergy and Immunology Section, Center for Biochemical Technology, New Delhi, INDIA, 2Center for Biochemical Technology, New Delhi, INDIA.

1038 Detection and Immunological Characterization of Hazelnut 2S Albumin J. Akkerdaas 1, F. Schocker 2, M. Alcocer 3, P. Schilte 4, A. Knulst 5, S. Hefle 6, E Ferreira 7, R. Aalberse I , R. Van Reel; qmmunopathol- ogy, Sanquin, Amsterdam, NETHERLANDS, 2Borstel Research Center, Bortsel, GERMANY, 3University of Nottingham, Notting- ham, UNITED KINGDOM, 4Medical Centre Alkmaar, Alkmaar, NETHERLANDS, 5UMCU, Utrecht, NETHERLANDS, 6FARRP, Lincoln, NE, 7University of Salzburg, Salzburg, AUSTRIA.

1039 Characterization of Black Walnut Pollen Allergens C. N. Porch-Curren, W.R. Peterso n, A. Xu, S. S. Teuber; UC Davis, Davis, CA.



Asthma Trigger Factors and Their Control 1040 One-Week Variability of Cotton Dust and Endotoxin Levels in

a Cotton Mill: Relation with Across-Shift Drop E. Castro, J. A. Ferreira, J. Tortes Costa, M. Vaz; Allergy Unit, Hospital S. Jo~o, Porto, PORTUGAL.

1041 Associations Among Gender, Race, and Age on Allergen Sensi- tivity in Patients with Objectively Diagnosed Asthma Recruit- ed into Asthma Clinical Research Network (ACRN) Protocols

T. J, Craig t, V. Chinchilli 2, E. Lehman 2, R. Zimmerman 3, R. Lemanske 4, H. Boushey 5, G. Pesola 6, ACRN Network7; IMedi- cine, Penn State University, Hershey, PA, 2Health Evaluation Sci- ence, Penn State University, Hershey, PA, 3Penn State University, Hershey, PA, 4University of Wisconsin, Madison, WI, 5University of California, San Francisco, CA, 6Columbia University, New York, NY, 7NHLBI, Wash, DC.

1042 Tobacco Smoking and Risk Factors for Atopie Disease in Infants K. Stencei-Gabriei; 3rd Clinics of Pediatrics, Silesian Medical Academy, Chorzow, POLAND.

1043 Periodic Assessment of Improvement in Pulmonary Function Following Quitting amongst Young Smokers K. S. M. Ishaq, I. Muhammad, F. K. M. Nawaiz; Allergy/ Immunology, AI-Junaid Hospital Nowshera, Nowshera, PAK- ISTAN.

1044 Non-occupational Induced Allergy to Monkey C. A. Copilevitz, P. A. Hutchesom R. G. Slavin; Saint Louis Uni- versity, St. Louis, MO.

1045 Relationship Between Parental Reports of Environmental and Food Triggers of Asthma Symptoms and Allergic Sensitiza- t i on -T he Childhood Asthma Research and Education (CARE) Network I, M. PauP, T. W. Guilbert 2, D. T. Mauger 3, S. J. Boehmer 3, R. F. Lemanske, Jr. 4, R. S. Zeiger s, T. J. Craig 6, E D. Martinez 2, S. J. Szefler 7, R. C. Strunk 8, L. M. Taussig 9, V. M. Chinchilli3; IPedi- atrics, Penn State College of Medicine, Hershey, PA, 2Respiratory Sciences Center, University of Arizona College of Medicine, Tuc- son, AZ, 3Health Evaluation Sciences, Penn State College of Med- icine, Hershey, PA, 4pediatrics, University of Wisconsin, Madison, WI, 5Pediatrics, University of California San Diego College of Medicine, La Jolla, CA, 6pulmonary Medicine, Penn State College of Medicine, Hershey, PA, 7pediatrics, National Jewish Medical and Research Center, Denver, CO, 8patient Oriented Research Unit, Washington University School of Medicine, St. Louis, MO, 9National Jewish Medical and Research Center, Denver, CO.

1046 Long-term Monitoring of the Immune Status of Children Liv- ing in Radionucleotide Contaminated Areas E. Kirylchyk I, L. Titov l, D. Charnashey I, L M. Du Buske2; tBelarus State Medical University, Minsk, BELARUS, 2Immunol- ogy Research Institute of New England, Fitchburg, MA.

1047 Seasonal Distribution of Cockroaches, a Major Source of Indoor Allergens, in Seoul, Korea C. KimL W. Kim I, K. Lee I . M. Shon l, G. Jang j, K. Kim l, I. Lee 2, K. Jeong 2, J. Lee 2, T. Yong 2, C. Kim 3, J. Park 3, C. Hong3; IPedi- atrics, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, 2parasitology, Yonsei University College of Medi- cine, Seoul, REPUBLIC OF KOREA, 31nternal Medicine, Yonsei University College of Medicine. Seoul, REPUBLIC OF KOREA.

1048 Dust Mite Numbers and Mite and Cockroach Allergen and Antigen Levels in Central Florida Homes R. Codina; Internal Medicine, University of South Florida, Tampa, FL.

1049 Domestic Mite Sensitization in German Patients--Including Chortoglyphus arcuatus and Gohieria fusca H. Miisken l, J. T. Franz 2, U. Schlensog 3, A. Heutelbeck 4, T. Schulz 4, C. Junghans 4, P. Tucholla 4, P. Hallier 4, K. C. Bergmannt; JAllergy and Asthma Clinic. Bad Lippspringe. GERMANY, 2Applied Biology, University of Paderborn, GERMANY, 3Hycor Biomedical, Kassel, GERMANY, 4Georg-August-University, Grt- tingen, GERMANY.

1050 Comparison of Swifter| to a Standard Electrostatic Cloth in Reducing Allergen Levels in Day Care Centers M, Rezvani l, R. Floyd 2, A. Perez 3, B. Lanphear 4, L. Levine 3, J. A. Bernstein2: qnternal Medicine, Jewish Hospital of Cincinnati, Cincinnati, OH, 2Internal Medicine/Division of lmmunology/AIler-

J ALLERGY CLIN IMMUNOL Abstracts $407 VOLUME 111, NUMBER 2

gy Section, University of Cincinnati College of Medicine, Cincin- nati, OH, 3Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, 4General Pediatrics/Division of Epi- demiology, Children's Hospital Medical Center, Cincinnati, OH.

1051 Survival of Dust Mites in Vacuum Storage Bags J. D. Miller; Allergy & Asthma Associates, Danbury, CT.

1052 Is Picture of Mucociliary Clearance after Irradiation Impor- tant for Patient's Prognosis? J. Foltinovfi L A. Schrott-Fischer 2, E. Neu 3, V. _ilfnek 4, V. Foltin 5, W. Freysinger6; qnstitute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, SK-81108 Bratisla- va, SLOVAKIA, 2University of lnnsbruck, University Clinic of Otorhinolaryngology, Anichstrasse 35, A-6020 Innsbruck, AUS- TRIA, 3Institute of Environmental Medicine, Feucht (bei Nuern- berg), GERMANY, 4pediatric Clinic-Oncol. div., Bratislava, SLO- VAKIA, 5FMFI UK, Comenius University, Mlynsk~ dolina, Department of Plasma Physics, SK-84248 Bratislava, SLOVAKIA, 6University of Innsbruck, University Clinic of Otorihinolaryngolo- gy, Anichstrasse 35, A-6020 Innsbruck, AUSTRIA.

Poster Session 5508


Insect Hypersensitivity 1053 Beekeeper's Serum Inhibits in Vitro Activity of Bee Venom

(BV) Phospholipase A2 (PLA2) D. Giamarchi, R. Escamilla, M. Prevost, C. Hermant, M. Krempf; Pneumo-allergologie, H6pital purpan, Toulouse, FRANCE.

1054 Massive Honeybee Envenomation and Plasmapheresis W. R. MeKenna 1, B. Hess2; llnternal Medicine, UTHSC San Antonio, Harlingen, TX, 2Family Practice, UTHSC San Antonio. Harlingen, TX.

1055 Profiling of Allergen-Induced Gene Expression in Subjects with Bee Venom Allergy S. Konno 1, D. B. K. Golden 1, J. Schroeder 1, T. E King 2, A. Kagey- Sobotka I . E. Raz 3, L. Lichtenstein I , S. K. Huangl; I Johns Hopkins University, Baltimore, MD, 2Rockefeller University, New York, NY, 3University of California, San Diego, CA.

1056 ICD-9 Coding of Emergency Department Visits for Bee Sting Allergy C. A. Camargo, Jr. I, T. J. Gaeta 2, G. S. KamarthiL S. Clarkl; 1Department of Emergency Medicine, Massachusetts General Hos- pital, Boston, MA, 2Department of Emergency Medicine, New York Methodist Hospital, Brooklyn, NY.

1057 Venom Immunotherapy (VIT) Results in a Modified Th2 Response A. Michiis ~ , A. Crusiaux I , S. BaldassarreL A. Ocman0, L. Schan- dene t, C. Ledent 2, M. Mairesse 2, M. Goldmanl; ICUB Erasme, Brussels, BELGIUM, 2CHR Saint Luc, Bouge, BELGIUM.

1058 Failure of Hymenoptera Venom lmmunotherapy (VIT) is Asso- ciated with the Use of Aspirin or Lipid-lowering Drugs P. Sch6pf, E Rueff, B. Przybilla; Klinik und Poliklinik fiir Derma- tologie und Allergologie, Mtinchen. GERMANY.

1059 In Vitro Inhibition of Hymenoptera Venom Phospholipase Activity after Desensitization R. Escamilla, D. Giamarchi, M. Prevost, C. Hermant, M. krempf; Pneumo-allergologie, H6pital purpan, Toulouse, FRANCE.

1060 Basophil Activation Test (BAT) and Lymphocyte Transforma- tion Test (LTT) in Wasp Allergic Patients After 3 years of Wasp Venom Immunotherapy K. J. De Knop, A. J. Schuerwegh, D. G. Ebo, C. H. Bridts, L. S. De Clerck, W. J. Stevens: Immunology-Allergology-Rheumatol- ogy, University of Antwerp. Antwerpen, BELGIUM.

1061 Imported Fire Ant (Solenopsis invicta) Venom Alkaloids Selec- tively Inhibit Nitric Oxide Synthase (NOS) Isoforms W. D. McCiendon, Jr., School of Medicine, University of Missis- sippi Medical Center, Jackson, MS.

1062 Stability of Hymenoptera Venom Skin Test Extracts D. Kelly, A, Meister, D. B. K. Golden, A. Kagey-Sobotka, P. S. Norman, R. G. Hamilton, L. M. Lichtenstein; Johns Hopkins Uni- versity, Baltimore, MD.

1063 Mosquito Bite-induced Systemic Reactions: Analysis of Saliva Specific-IgE and -lgG Antibodies to 5 Species in 14 Individuals A. Beckett I, E. Simons 2, Z. Peng2; IPediatrics, Univefisty of Man- itoba, Winnipeg, MB, CANADA, 2Pediatrics and Immunology, University of Manitoba, Winnipeg, MB, CANADA.

Poster Session 5509


Penicillin Allergy 1064 Importance of Dendrimer Size in the Hapten Density in a Con-

jugate for in vitro Testing to Determine lgE Antibody in Patients Allergic to Betalactams C. Mayorga l, M. J. Torres 1, E. Perez-Inestrosa 2, F, Sanchez-San- cho 2, M. I. Montafiez 2, J. L. Rodriguez-Bada I, A. G. Romano 3, R. Suau 2, M. Blanca4; IResearch Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, SPAIN, 2Organic Chemical Depart- ment, Science Faculty, University of Malaga, Malaga, SPAIN, 3Internal Medicine and Geriatrics and Allergy Unit, UCSC and C. I. Columbus, Rome, ITALY, 4Allergy Service, La Paz Hospital, Madrid, SPAIN.

1065 Skin Tests in the Diagnosis of Penicillin Allergy A. M. L. Pregal, A. Vinhas de Sousa, E. Pedro, S. Lopes da Silva, A. Spinola Santos, T. Michelena, M. Branco Ferreira, A. G. Palma- Carlos; Immunoallergology, HSM, Lisbon, PORTUGAL.

1066 Skin Test Resensitization after Allergological Study in Patients with Immediate Allergic Reactions to Betalactams M. C. Moya I, M. J. Tortes 2, J. A. Cornejo-Garcia 2, C. Mayorga 2, C. Antunez 2, J. L. Rodriguez-Bada 2, M, Blanca 3, C. Juarez2; t Allergy Unit, Torrecardenas Hospital, Almeria, SPAIN, eResearch Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, SPAIN, 3Allergy Service, La Paz Hospital, Madrid, SPAIN.

1067 Diagnosing Non-immediate Reactions to Betalactams: Intra- dermal and Skin Patch Testing Standardization M, J. Tortes L, J. Fernandez 2, C. Mayorga l, E. Sanchez 3, A. Padi- al 3, J. A. Cornejo-Garcia 1, A. G. Romano 4, M. Blanca3; IResearch Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, SPAIN, 2Allergy Unit, Elche Hospital, Elche, Alicante, SPAIN, 3Allergy Service, La Paz Hospital, Madrid, SPAIN, 4Internal Med- icine and Geriatrics and Allergy Unit, UCSC and C. I. Columbus, Rome, ITALY.

1066 Repeat Penicillin Skin Testing After Penicillin Use Associated Adverse Drug Reactions in Penicillin Skin Test Negative Indi- viduals E, Macy 1, R. Mangat2; 1Department of Allergy, Kaiser Permanente San Diego, San Diego, CA, 2Allergy/Immunology, UCSD School of Medicine, San Diego, CA.

1069 Study of IgE Antibody Specificity to Penicillin after a Boosting Process in Patients Allergic to Betalactams M. Blanca l, C. Moya 2, J. L. Rodriguez-Bada 3, M. J. Tortes 3, J. A. Cornejo-Garcia 3, C. Antunez 3, A. G. Romano 4, C. Mayorga3; IAllergy Unit, La Paz Hospital, Madrid, SPAIN, 2Allergy Unit, Hospital Torrecardenas, Almeria, SPAIN, 3Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, SPAIN, 4Internal Medicine and Geriatrics and Allergy Unit, UCSC and C. I. Columbus, Rome, ITALY.


1070 Penicillin Major and Minor Determinants Have High Negative Predictive Value When Cephalosporins Are Administered to Penicillin-Allergic Patients P. A. Greenberger; Allergy-Immunology Division, Northwestern University Fcinberg School of Medicine, Chicago, IL.

1071 Characteristics of a Group of Immediate Reactions to Betalac- tams Selected During 2000-2002 M. PadiaP, R. Blanco j, M. Belver I, M. Tortes 2, C. Mayorga 2, M. Blancal; IAllergy Service, University Hospital La Paz, Madrid, SPAIN, 2Research Unit for Allergic Diseases, Carlos Haya Hospi- tal, Malaga, SPAIN.

1072 Allergy to 13-Lactam Antibiotics--Comparing Pediatric and Adult Patients L. M. Borrego, P. Leiria-Pinto, C. Braga, T. Almeida, A. Gaspar, E. Pargana, J. Rosado-Pinto; lmmunoallergy Department, Dona Estef~nia Hospital, Lisbon, PORTUGAL.

1073 Allergy to Beta-Lactam Antibiotics in Children in Southern Israel J. Hershkovich 1,2, L. Kirjner 3, H. Smit 4, N. Medan 5, R. Gorodis- cher3,6; JPediatric Allergy Clinic, Soroka Medical Center, Beer- Sheva, ISRAEL, 2Faculty of Health Sciences, Ben-Gurion Univer- sity of the Negev, Beer-Sheva, ISRAEL, 3pediatric Department "A," Soroka Medical Center, Beer-Sheva, ISRAEL, 4Farmacology, Soroka Medical Center, Beer-Sheva, ISRAEL, 5Soroka Medical Center, BeevSheva, ISRAEL, 6Faculty of Health Sciences, Ben- Gurion University of the Negev. Beer-Sheva, ISRAEL.

Poster Session 5510


Factors Affecting the Quality of Care in Atopic Disorders 1074 Characterization of Baltimore City School Children with Asth-

ma Evaluated on the Breathmobile C. D. Schwindt, C. Blaisdell, M. Ramagopal, S. Irving, M. Foster, K. Mudd, M. Bol]inger; Pediatrics, University of Maryland Med- ical System, Baltimore, MD.

1075 Clinical and Therapeutic Aspects of Allergic Asthma in Adoles- cents C, Lombardi f , E Gani 2, M. Landi 3, G. W. Canonica 4, G. Passalac- qua4; qmmunoallcrgology-Dcpc of Medical Sciences, S. Orsola Fatebenefratelli Hospital Brescia, Brescia, ITALY, 2S. Luigi Hospi- tal Orbassano, Allergy Unit, Orbassano (Turin), ITALY, 3National Paediatric Healthcare, Turin, ITALY, 4Dept of Internal Medicine, Genoa University Allergy & Resp. Diseases, Genoa, ITALY.

1076 The Economic Impact of Asthma in Continuous Evaluation C. Nunes, S. Ladeira; Center of Allergy and Immunology of Algarve, Portimao, PORTUGAL.

1077 The Impact of an Asthma Health Management Program using a Self-Reported Risk Stratification Algorithm on Patient Reported Outcomes M. I. L iebhaber I, D. S. Armstrong 2, M. Weiss 3, L. Beers 3, Z. Dyer3; ~Allergy/Immunology, Sansum-Santa Barbara Medical Foundation Clinic, Santa Barbara, CA, 2Outcomes Research, Schering-Plough Managed Care, La Verne, CA, 3Sansum-Santa Barbara Medical Foundation Clinic, Santa Barbara, CA.

1078 Predictors of Poor Outcomes in a Cohort of Children with Mild Persistent Asthma A. Luskin, D. Bukstein, R. Olson; Dean Foundation for Health, Research and Education, Middleton, WI.

1070 Physician Assistants Enhance Quality of Care in Asthma Patients G. E Thomas I, R. J. McNellis 1, G. R. Ortiz2; iAmerican Academy of Physician Assistants, Alexandria, VA, 2Allergy & Asthma Cen- ter of El Paso, E1 Paso, TX.

1080 Nasal Polyps Contra Nasal Polyposis--The Sk6vde Population- Based Study L. Johansson t, A. /~,kerlund 2, K. Holmberg 3, I. Mel6n I, M. BendO; IDept of ENT, Sk6vde, SWEDEN, 2AstraZeneca R&D, Lund, SWEDEN, 3Sahlgrenska University Hospital, G6teborg, SWEDEN.

1081 Wide Variation from the NHLBI Guidelines for Asthma Still Persists in Practice D.A. Buchner I , K. M. Blasko 2, A. White 1 , L. V. Goodman i , J. Fei- gin J, A. Georgiou3; I Schering Laboratories, Kenilworth, N J, 2Unit- ed Health Group, Edina, MN, 3UnitedHealth Group, Minnetonka, MN.

1082 Patterns of Quick-Relief and Long-Term Controller Medica- tion Use in Pediatric Asthma N. Walders, E. L. McQuaid, S. J. Kopel, D. Koinis-Mitchel[; Child and Family Psychiatry, Rhode Island Hospital/Brown University School of Medicine, Providence, RI.

1083 Multidisplinary Approach to Asthma Management with a Minority Population in an Urban Managed Care Organization E S. Austin I, M. Banks I , E. V. Davis 2, T. Eason 3, A. Palmer 4, J. R. Edwards Z; I Chartered Health Plan, Washington, DC, 2DC Depart- ment of Health, Washington, DC, 3Consultant, Bowie, MD, 4Mont- gomery County Health Department, Rockville, MD.

1084 The Histamine-Induced Wheal and Flare: A Systematic Review of Methodology A. Daly, T. Systematic Review Group; Healthcare Dimensions, Dublin, IRELAND.

1085 Group Discussions with Parents of Pre-school Children--Posi- tive Effects on the Management of Asthma C. Hederos I, S. Janson 2, G. Hedlin3; 1Barn-Ungdomsmedicin, Pri- mary Care Research Unit VC Gripen, Karlstad, SWEDEN, 2VC Gripen, Primary Care Research Unit VC Gripen, Karlstad, SWE- DEN, 3Astrid Lindgrens Hospital, Karolinska Institutet, Stock- holm, SWEDEN.

1086 Family Recall of Treatment Plans and Its Relation to Medica- tion Adherence in Pediatric Asthma C. D. Adams l, K. E. Joseph [, T. Ash j, C. Dotson j, N. W. Wilson 2, M. B. Hogan2; iDepartment of Psychology, West Virginia Univer- sity, Morgantown, WV, 2Department of Pediatrics, West Virginia University, Morgantown, WV.

Poster Session 5511


Animal Models of Allergic Inflammation 1087 Oral Antigen-induced Intestinal Anaphylaxis Requires IgE-

dependent Mast Cell Degranulation E. B. Brandt i, R. T. Strait 2, Q. Wang 3, D. Hershko 3, E. MunteP, E D. Finkelman 2,4, M. E. Rothenbergl; 1Division of Allergy and Immunology, Children's Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, College of Medicine, Cincinnati, OH, 3Shriners Hospitals for Children, Cincinnati, OH, 4Veteran's Administration Medical Center, Cincinnati, OH.

1088 Eotaxin-2 is Critical for Eosinophil Recruitment into the Air- way Lumen in Experimental Asthma S. M. Pope, N. Zimmermann, P. C. Fulkerson, M. E. Rothenberg; Allergy & Immunology, Children's Hospital of Cincinnati, Cincin- nati, OH.

1089 Influence of TLR4 on Immune Reactivity to Fed Antigens in a Mouse Model of Food Allergy C. Berin, X. Li, H. A. Sampson; Pediatric Allergy & Immunology, Mount Sinai School of Medicine, New York, NY.

J ALLERGY CLIN IMMUNOL Abst rac ts $409 VOLUME 111, NUMBER 2

1090 Does Mycobacterium vaccae Immunization to Pregnant BALB/c Mice Alter Cytokine Levels in Spleen Cultures, Bone Marrow Eosinophils, and Lung Histopathology in Offsprings with Chronic Asthma Model? T. AkkoO, C. Ozdemir I, O. YesiP, D. YazP, N. N. Bahceciler I, S. llgar 2, O. Peker 2, I. B. Barlanl; 1Pediatric Allergy-Immunology, Marmara University Hospital, Istanbul, TURKEY, 2Pathology Department, Haydarpasa Numune Hospital, Istanbul, TURKEY.

1091 Pro-oxidant Activity of Pollen and Mold Proteins Induces Oxidative Stress in the Lungs Independent of Adaptive Immu- nity A. Bacsi l, S. Sur 2, B. K. Choudhury 2, R. Alam 2, I. Boldoght; IDepartment of Microbiology and Immunology, UTMB, Galve- ston, TX, 2Internal Medicine, NIH Asthma and Allergic Diseases 2:00 Research Center, UTMB, Galveston, TX. 1102

1092 Attenuation of Allergic Inflammation by Neutralization of IGF-I in Murine Asthmatic Models N. Yamashita I, H. Tashimo t, M. Nakajima 1, H. lshida t, M. Kuramochi l, E Kaneko t, R. Kawashima l, T. Horiuchi 2, K. OhtaJ; tTeikyo University School of Medicine, Tokyo, JAPAN, 2Kanto Central Hospital, Tokyo, JAPAN.

1093 Chromosomal Substitutions between Rat Strains with Thl- or Th2-biased Responses: A Novel Strategy for Physiogenomic Studies of Allergic Inflammation R. F. Lemauske, Jr. 1 , L. D. Mikus I , A. Tuffaha I , R. L. Sorkness 1,2, 2.'15 A. W. Cowley, Jr. 3, H. J. Jacob 3, L. A. Rosenthall; IUniversity of 1103 Wisconsin Medical School, Madison, WI, 2University of Wiscon- sin School of Pharmacy, Madison, WI, 3Medical College of Wis- consin, Milwaukee, WI.

1094 Expression of uPAR (CD87) on Airway Eosinophils (EOS) Fol- lowing Segmental Bronchoprovocation with Allergen (SBP- 2:30 AG) 1104

J. B. Sedgwick, A. M. Brooks, E. A. Hazel, W. W. Busse; Medi- cine, University of Wisconsin, Madison, WI.

1095 Blockade of L-Selectin Enhances Airway Hyperresponsiveness (AHR) Through Inhibition of Thl Responses Following Aller- gen Sensitization and Challenge 2:45 K. Takeda, N. Miyahara, T. Kodama, A. Joetham. C. Taube, A. 1105 Balhorn, A. Dakhama, E. W. Gelfand; Pediatrics, National Jewish Medical and Research Center, Denver, CO.

1096 Comparison of Toll-Like Receptor Expression in Eosinophils, Basophils, and Neutrophiis H. Nagase 1 , Y. Ohta I , M. Yamaguchi I , K. Matsushima 1, K. Ohta 2, K. Yamamotol, K. Hirail ; t Univ. of Tokyo, Tokyo, JAPAN, 2Teikyo Univ. Sch. of Med., Tokyo, JAPAN.

109"I A Genetically Modified Plant Expressing a Gene for a Potential 3:00 Allergen Can Suppress Experimental Allergy 1106 S. E Hogan t , V. Smart l, P. S. Foster I , M. E. Rothenberg 2, T. J. V. Higgins3; IAllergy and Inflammation Research Group Laboratory John Curtin School Medical Research, Canberra, AUSTRALIA, 2Department of Pulmonary Medicine, Allergy and Clinical 3:15 Immunology, Children's Hospital Medical Center, Cincinnati, OH, 110"I 3CSIRO Plant Industry, Canberra, AUSTRALIA.

1098 The Effect of Stress on Airway Inflammation in Mice P. Forsythe, C. Ebeling, D. Befus, H. Vliagoftis; Medicine, Uni- versity of Alberta, Edmonton, AB, CANADA.

1099 Interactions Between Der p 1 and Secretory Leucoprotease Inhibitor N. Sehgal, E Smillie, A. Custovic, A. Woodcock; North West Lung 3:30 Research Centre, Wythenshawe Hospital, Manchester, UNITED 1108 KINGDOM.

1100 Membrane-Bound and Soluble Stem Cell Factor Expression by Skin Cells during Atopic Dermatitis in Dogs B. HammerbergL A. K. Smith2; ICollege of Veterinary Medicine, North Carolina State University, Raleigh, NC, 2North Carolina State University, Raleigh, NC.

1101 Immunomodulatory Role of Endotoxin in the Development of Latex Allergy M, D. Howell t, B. Meade2; IDepartment of Pediatrics, National Jewish Medical and Research Center, Denver, CO, 2Agriculture and Immunotoxicology Group, National Institute for Occupational Safety and Health, Morgantown, WV.


Tuesday, March 11 2:00 PM to 4:00 PM

Asthma Mechanisms 11

Inflammatory Responses in Respiratory Syncytial Virus and Other Viral Infections in Infants: Cytokines, Chemokines, and Eosinopilic Cationic Protein S. Kristjansson I, S. Bjarnarson 2, 1. Jonsdottir 2, T. Arnadottir 3, G. Wennergren 4, A. HaraldssonS; I Department of Pediatrics, Landspi- tall, University Hospital, Reykjavik, ICELAND, 2Department of Immunology, Reykjavik, ICELAND, 3Department of Virology, Reykjavik, ICELAND, 4Department of Pediatrics, The Queen SiP via Children's Hospital, G6teborg, SWEDEN, ~Department of Pediatrics, Reykjavik, ICELAND.

Inhibition of Matrix Metalloproteinases Reduces Th2 Cytokine Production and Alters Sensitivity to Inhaled Methacholine (MCh) A, Balhorn, C. Taube, K. Takeda, E. W. Gelfand, A. Dakhama; Pedi- atrics, National Jewish Medical and Research Center, Denver, CO.

Up-Regulation of CD23 (FceRII) Expression in Human Airway Smooth Muscle Cells (huASMC) After Exposure to IL-4, GM- CSF, and IL-4/GM-CSF J. T. Belleau; Allergy and Immunology, University of Tennessee, Memphis, Memphis. TN.

Chemokine Receptors in Human Airway Smooth Muscle Cells: Inducible Expression of Functional CCR3 B. Lamkhioued t, S. Lajoie-Kadoch 2, K. Maghni 3, A. Soussouni 4. Q. Hamid 2, P. Joubert2: qmmunologie et Pathologic Respiratoires, H6pital Notre-Dame-CHUM, Montreal, PQ, CANADA, 2patholo- gy, Meakins-Christie Laboratories, McGill University, Montreal, PQ, CANADA, 3H6pital Sacr6-Choeur, Montreal, PQ, CANADA, 41mmunology, University of Winipeg, Winipeg, MB, CANADA.

Elevated Substance P Levels in Nasal Lavage Fluid of Chronic Nonproductive Cough Patients Y. Cho, S. Park, C. Lee, B. Yoo, H. Moon; Allergy and Rheuma- tology, Asan Medical Center, Seoul, REPUBLIC OF KOREA.

CD63 Association with Compound Exocytosis in Peripheral Blood Eosinophils S. Mahmudi-Azer t, S. O. Odemuyiwa 2, R. Moqbel3; IMedicin, University of British Columbia, Vancouver, BC, CANADA, 2Department of Medicine, University of Alberta, Edmonton, AB, CANADA, 3Department of Medicine, University of Alberta, Edmonton, AB, CANADA.

Hydrolytic Activities of Phospholipase A 2 and Eosinophil Lysophospholipases Cause Pulmonary Surfactant Dysfunc- tion: A Mechanism for Small Airway Closure in Asthma M. A. Kwatia t, C. B. Doyle t, G. Enhorning 2, S. J. AckermanJ; 1Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, Chicago, IL, 2Department of Gynecology and Obstetrics, State University of New York at Buffalo, Buffalo, NY.




Rhinitis and Sinusitis 2:00 1109 The Airway Distribution of Rhinovirns Following an Experi-

mental Inoculation R. F. Vrtis, K. A. Schwantes, J. E. Gern, W. W. Busse; Medicine, University of Wisconsin, Madison, WI.

2:15 1110 Assesment of Dynamics of Nasal Congestive Responses to

Prostaglandin D2 (PGD2) with Acoustic Rhinometry S. Sidhani L, J. Leroux t, E. Khemici j, M. Haasz 1, M. Y. Desrosiers2; tCentre Hospitalier de l'Universit6 de Montr6al, Montreal, PQ, CANADA, 2Nasal Physiology Laboratory, Centre Hospitalier de l'Universit6 de Montr6al, Montreal, PQ, CANADA.

2:30 1111 Siblings, Daycare, and Culture-Confirmed Viral Respiratory

Infections in the First Year of Life K. A. Roberg 1, C. Tisler I, K. Carlson-Dakes t, E. Anderson 1, D. DaSilva j, Z. Li t, C. Kirk 2, P. Shult 2, R. Gangnon ], J. Gem I, R. Lemanske, Jr.]; i University of Wisconsin Medical School, Madi- son, WI, 2Wisconsin State Laboratory of Hygiene, Madison, WI.

2:45 1112 Age-related Maturation of the Nasal Immune System in Children

I. J. Van Benten I, C. M. Van Dmnen 1, B. C. Van Middelkoop I , L. P. Koopman 2, B. G. M. Niesters 3, W. C. J. Hop 4, A. D. M. Oster- haus 3, H. J. Neijens 2, W. J. Fokkensl; IOtorhinolaryngology, Eras- mus MC, Rotterdam, NETHERLANDS, 2Paediatrics, Erasmus MC, Rotterdam, NETHERLANDS, 3Virology, Erasmus MC, Rot- terdam, NETHERLANDS, 4Epidemiology and Biostatistics, Eras- mus MC, Rotterdam, NETHERLANDS.

3:00 1113 Evaluation of an Environmental Exposure Unit (EEU) for Con-

trolled Inhalation Studies with Pollen Allergens J. M. Hohlfeld, H. Windt, W. Dunkhorst, H. L6dding, H. Geld- reacher, W. Koch, N. Krug; Fraunhofer-lnstitute of Toxicology and Aerosol Research, Hannover, GERMANY.

3:15 1114 Validation of the Classification of Aria (Allergic Rhinitis and its

lmpact on Asthma) P. Demoly i , F. Allaert 2, J. Bousquet3; IAllergology and Respirato- ry Medicine, University Hospital of Montpellier, Montpellier, FRANCE. 2CEN Biotech, Dijon, FRANCE, 3University Hospital of Montpellier, Montpellier, FRANCE.

3:30 1115 Allergy is a Negative Prognostic Factor for the Outcome after

Sinus Surgery M. Wagenmann, A. Rietschel, U. Ganzer; HNO-Klinik Oni Dues- seldorf, Duesseldorf, GERMANY.

3:45 1116 Correlation of Specific and Total IgE Serum Levels with Symp-

toms and Effects of Anti-IgE Treatment in Children with Sea- sonal Allergic Rhinitis (S/kR) E. H. Hamclmann 1, C. Rolinck-Werninghaus l, M. Kopp 2, J. Kuehr 2, U. Wahnl; I Pediatric Pneumology and Immunology, Uni- versity Hospital Charit6, Berlin, GERMANY, 2Children Hospital, University, Freiburg, GERMANY.



Mechanisms and Treatment of Rhlnitis 2:00 111"/ The Anti-inflammatory Response of Anti-eotaxin Monoelonal

Antibody CAT-213 on Nasal Allergen-induced Cell Infiltration and Aetivation

2:15 1118

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2:45 1120

3:00 1121

3:15 1122

3JO 1123

R. Salib t, M. Salagean l, L. Lau I , I. DiGiovanna 2, N. Brennan 3, G. Scadding 4, P. Howarth I; 1Division of Respiratory Cell and Molec- ular Biology, University of Southampton, Southampton, UNITED KINGDOM, 2Campbell Charles Associates, London, UNITED KINGDOM, 3Medical Development Department, Cambridge Anti- body Technology, Cambridge, UNITED KINGDOM, 4Clinical Immunology, Allergy and Rhinology Department, Royal National Throat, Nose and Ear Hospital, London, UNITED KINGDOM.

Omalizumab Rapidly Inhibits Nasal Allergic Responses H. Lin, E A. Romero, K. M Boesel, D. T. Griffith, T. B. Casale; Division of Allergy/Immunology, Creighton University Medical Center, Omaha, NE.

Nasal Epithelial Cells Express the FceRI: IL-4 Induced Upreg- ulation of the FcERI and IL-6 Production S. Yamagishi, R. Pawankar, R. Takizawa, M. Nonaka, T. Yagi; Nippon Medical School, Tokyo, JAPAN.

Mometasone Furoate Nasal Spray (MFNS) 100 mcg qd Had a Low Potential for Systemic Exposure in Pediatric Patients With Allergic Rhinitis Ages 2 to Less Than 6 Years Old J. Herron; Arkansas Research Medical Testing Center, Little Rock, AR.

Synergestic Induction of TARC in Nasal Epithelial Cells and Fibroblasts by IL-4/IL-13 and TNF-alpha, and its Relation to CCR4+ IL-4+ T Cells in Patients with Allergic Rhinitis R. Pawankar i, S. Yamagishi I , M. Nonaka i , K. Hirai 2, C. Ozu I , S. WatanabO; IOtolaryngology, Nippon Medical School, Tokyo, JAPAN, eBioregulatory Function, University of Tokyo, Tokyo, JAPAN.

Effect of a Nasal Steroid, Antileukotriene, or Antileukotriene + Antihistamine on Leukotriene Levels in Nasal Lavage in Aller- gic Rhinitis Patients T. Pullerits, J. L6tvall: Lung Pharmacology Group, Gothenburg, SWEDEN.

Eosinophilic Inflammation and Interleukin 5 Receptor Alpha Isoform Expression in Eosinophilic Airway Diseases P. G. A. Gevaert l, C. Bacher0, G. Holtappels I, C. Perez I, P. Howarth 2, L. Fransen 3, J. Tavernier 4, P. van Cauwenberge]; IOtorhinolaryngology, Ghent University Hospital, Ghent, BEL- GIUM, 2Southampton General Hospital, Southampton, UNITED KINGDOM, 31nnogenetics, Ghent, BELGIUM, 4Medical Protein Research, Ghent University, Ghent, BELGIUM.



Mechanisms and Treatment of Urticaria 2:00 1124 Usefulness of the Basotest to Detect Basophil Activating Auto-

antibodies in Chronic Idiopathic Urticaria (CIU) C. Van den Keybus I, A. De Swerdt 2, A. Kasran 2, J. L. Ceuppens2; IDepartment of Dermatology, University Hospital, Leuven, BEL- GIUM, 2Department of Experimental Immunology, Catholic Uni- versity, Leuven, BELGIUM.

2:15 1125 Total Histamine Content in Blood Predicts the Presence of

Autoantibodies against IgE/IgE-receptor in Patients with Chronic Urticaria P. S. Skov t, M. H. Platzer l, L. K. Poulsen 2, C. Bindslev-Jensen3; iAllergy Unit-7512, National University Hospital, Copenhagen,

J ALLERGY CLIN IMMUNOL Abstracts $411 VOLUME 11% NUMBER 2

DENMARK, 2Allergy Unit-7542, National University Hospital, 2:45 Copenhagen, DENMARK, 3Allergy Center-Department of Der- 1134 matology, Odense University Hospital, Odense, DENMARK.

2.'30 1126 Monoclonal Gammopathies of Undetermined Significance

(MGUS) in Patients with Chronic Urticaria (CU) M. Karakelides t, K. L. Monson 2, J. J. Jacobsen 2, G. Volcheck 2, J. H. Butterfield 2, C. R. Weiler2; ]Sophie Davis School of Biomedical Education, New York, NY. 2Mayo Clinic, Rochester, MN. 3:00

2:45 1135

1127 Impact of Desloratadine on Signs, Symptoms, and Quality of Life Measures of Chronic Idiopathic Urticaria (CIU) in Clini- cal Practice A. Kapp I, A. Plenker2; IDepartment of Dermatology, University 3:15 of Hannover Medical School, Hannover, GERMANY, 2Essex 1136

Pharma, Munich, GERMANY. 3:00 1128 Cyclosporin for Chronic Idiopathic Urticaria in Children

D. R. Doshi I, M. M. Weinberger2; ]University of Iowa, Iowa City, 3:30 IA, 2pediatrics, University of Iowa, Iowa City, IA. 1137

3:15 1129 Cetirizine from Topical Rigid Liposomal Formulations: Evalu-

ation of Peripheral Antihistaminic Activity and Systemic Absorption in a Rabbit Model K. J. Simons 1, A. A. W. Elzainy I, X. Gu I, E. R. Simons2; IPhar- macy, University of Manitoba, Winnipeg, MB, CANADA, ?Pedi- atrics, University of Manitoba, Winnipeg, MB, CANADA.

3:30 1130 Familial Cold Autoinflammatory Syndrome: An Entity Distinct 3:45

from Cold Urticaria 1138

R. L. Shpall l, E. W. B. Jeffes 2,3, H. M. Hoffman4; LCollege of Medicine, University of California, lrvine. Irvine, CA, 2Division of Dermatology, VA Medical Center-Long Beach, Long Beach, CA, 3Department of Dermatology, University of California at Irvine, Orange, CA, 4Departments of Pediatrics and Medicine, University of California at San Diego, San Diego, CA.

Ora l Abs t rac t Session Signal 5715 2.'00

Tuesday, March 11 1139 2:00 PM to 4:00 PM

Food Hypersensitivity: Diagnostic Strateg4es, Allergens, and Awareness 2:00 1131 The Impact of Oral Food Challenges on Food-Specific IgE

Antibody Concentrations E, J. Vukic, M. Mishoe, S. A. Noone, H. A. Sampson, S. H. Sicher- er; Pediatrics, Mount Sinai School of Medicine, New York, NY.

2:15 2.'15 1132 Threshold Dose for Egg Allergy Determined by Oral Challenge 1140

S. Hefle 1, L. Christie 2, S. Sicherer 3, K. Althage 2, A. Burks 2. H. Sampson 3, S. Mofidi 3, S. Noone 3, L. Michaelis 4, S. Strobel 4, J. Hourihane 5, J. Nordlee ] , S. Taylorl; IUniversity of Nebraska, Food Allergy Research & Resource Program, Lincoln, NE, ?Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, 3Department of Pediatrics, Mr. Sinai Hospital, New York, NY, 4Institute of Child Health, Lon- don, UNITED KINGDOM, 5Southampton University Hospital. Southampton, UNITED KINGDOM. 2:30

2:30 1141

1133 Recognition of Sequential and Conformational Structures of Ovomucoid Varies in Patients with Long-lasting and Transient Egg Allergy K. M. Jarvinen, K. Beyer, L. Bardina, M. Mishoe, H. A. Sampson; Div. of Pediatric Allergy and Immunology and Jaffe Institute for Food Allergy, Mount Sinai School of Medicine, New York, NY.

Mutational Analysis of IgE-Binding Epitopes of the Major Cow's Milk Allergen [3-Casein Showed a Heterogenous Pattern of Critical Amino Acids between Individual Patients and Pooled Sera R. R. Cocco, K. M. Jarvinen, N. Han, P. Chatchatee, H. A. Samp- son, K. Beyer; Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY.

Comparison of Genetically Modified Soybeans and Wild Soy- beans in Immunologic Aspects H. Yum; Pediatrics, Pochon Cha University, Seoul, REPUBLIC OF KOREA.

Tolerance to Apple after Microwave Heating M. Santaolalla, M. L. Baeza, L. Zapatero, C. Frutos, A. Rodriguez, J. Zubeldia, E. Alonso, I. Martinez; Allergy, Gregorio Marafion Hospital, Madrid, SPAIN.

Development and Validation of Materials for Double-Blind Placebo-Controlled Food Challenge (DBPCFC) Tests in Chil- dren B. J. Vlieg-Boerstra I, C. M. Bijleveld 2, S. van der Heide t, B. J. Beusekamp 3, S. S. A. Plompen z, J. Kukle#, E. J. Duiverman 2, A. E. J. Dubois]; ]Dept. Allergy, University Hospital Groningen, Groningen, NETHERLANDS, 2Dept. Pediatrics, University Hos- pital Groningen, Groningen, NETHERLANDS, 3Dept. Dietetics, University Hospital Groningen, Groningen, NETHERLANDS.

College Student Food Allergy Awareness A. M. Singer, G. Sanders, M. McMorris; Division of Allergy, Uni- versity of Michigan, Ann Arbor, Ml.



Transduetion and Gene Regulation in Effector Cells

Rapid Tyrosine Phosphorylation of a Major Small MW Protein Following Fc~RI Aggregation in Human Mast Cells (HuMCs): Identification as a Novel Transmembrane Adaptor Protein Similar to LAT C. Tkaczyk I, V. Horejsi 2, D. D. MetcalfO, A. M. Gilfillanl; 1Lab- oratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, MD, elnstitute of Molecular Genetics, Academy of Sci- ences of the Czech Republic, Prague. CZECH REPUBLIC.

Gi2, but Not Gi3, Signaling is Required for Eosinophil Accu- mulation in Allergic Pulmonary Inflammation J. J. LeO, M. T. Borchers I, T. L. Ansay 2, E. M. Hines 2, L. Birn- baumer 3, N. A. Lee2; 1Department of Biochemistry and Molecular Biology, Division of Pulmonary Medicine, Mayo Clinic Scotts- dale, Scottsdale, AZ, 2Department of Biochemistry and Molecular Biology, Division of Hematology/Oncology, Mayo Clinic Scotts- dale, Scottsdale. AZ, 3Molecular, Cell, and Developmental Biolo- gy, UCLA, Los Angeles, CA.

Trefoil Factor-2 (TFF2) is an Allergen-induced Gene Differen- tially Regulated by SignaI-Transducer-and-Activator-of-Trati- scription (STAT)6 in Experimental Asthma N. M. Nikolaidis I, N. Zimmermann 2, A. M. Mishra 2, N. E. King 2, S. M. Pope 3, M. E. Rothenberg2; 1Department of Cellular and Mol- ecular Biology. University of Cincinnati, Cincinnati, OH, 2Depart- ment of Pediatrics. Cincinnati Children's Hospital Medical Center,


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3:15 1144

Cincinnati, OH, 3Molecular Genetics, Biochemistry, and Microbi- ology, University of Cincinnati, Cincinnati, OH.

Cycling of Stat6 is Required for Maintenance of Stat6 Activa- tion and IL-4 Dependent Gene Induction M. O. Daines, R. P. Andrews, M. B. Ericksen, C. M. Cunningham, G. K. Khurana Hershey; Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Role of IL-18 Mediated Innate Immune Response in IL-4 and STAT-6 Independent Th2 Differentiation B. K. Choudhury, J. S. Wild, R. Alam, S. Sur; NIH Asthma and Allergic Diseases Research Center and the Departments of Internal Medicine, University of Texas Medical Branch, Galveston, TX.

Chitosan IFN-gamma-gene Nanoparticle (CIN) Therapy for Allergic Asthma in Mice Involves STAT4 Signaling Pathway

3JO 1145

3:45 1146

X. Kong l, M. Kumar~, A. Behera j, G. Hellerman 1, R. E Lockey 1, S. S. Mohapatra2,3; JUniv of South Florida, Tampa, FL, 21nternal Medicine (MDC-19), Univ of South Florida Coil of Med, Tampa, FL, 3James A, Halley VA Hospital, Tampa, FL.

Immunoiogicaily Activated Human Basophils Are Differential- ly Affected by Calcineurin Antagonists in Mediator Secretion, Activity of p38 Mitogen Activated Protein Kinase (p38 MAPK), and Extracellular Signal Related Kinases (ERK) K. E. S. Plath; Dermatology, University of Luebeck, Luebeck, GERMANY.

Activation of Select Src Family Tyrosine Kinases by the CC Chemokine Receptor-3 (CCR3) in Eosinophils R. Bloebaum I, T. Adachi 2, S. Stafford I, R. Alaml; IThe Universi- ty of Texas Medical Branch, Galveston, TX, 2Akita University School of Medicine, Akita, JAPAN.

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