Curriculum Vitae – Sep Eskandari, Ph.D. Page 1 of 18 Curriculum Vitae Sepehr (Sep) Eskandari, Ph.D. Interim Associate Vice President for Academic Planning and Faculty Affairs Professor, Biological Sciences Department California State Polytechnic University, Pomona 3801 West Temple Avenue Pomona, California 91768 Faculty Affairs office: CLA T7-8 | 909.869.4182 Faculty office: 8-33A | 909.869.4182 Cell phone: 909.973.2010 E–mail: [email protected]Faculty Affairs web site: http://www.cpp.edu/~faculty-affairs/ Faculty web site: http://www.cpp.edu/~seskandari/ GATMD: http://physiology.sci.cpp.edu/GATMD/ EDUCATION B.S. Chemistry 1993 Chemistry Department California State Polytechnic University, Pomona M.S. Biology (Emphasis: Integrative Physiology) 1995 Biological Sciences Department California State Polytechnic University, Pomona Mentor: Daniel F. Stiffler, Ph.D. Ph.D. Physiology 1999 Department of Physiology School of Medicine University of California, Los Angeles (UCLA) Mentor: Ernest M. Wright, D.Sc. Post-Doctoral 1999 – 2000 Training Departments of Physiology and Neurobiology School of Medicine University of California, Los Angeles (UCLA) Mentors: Guido A. Zampighi, Ph.D. and Ernest M. Wright, D.Sc.
Transcript
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 1 of 18
Curriculum Vitae
Sepehr (Sep) Eskandari, Ph.D. Interim Associate Vice President for Academic Planning and Faculty Affairs
Professor, Biological Sciences Department California State Polytechnic University, Pomona
Faculty Affairs web site: http://www.cpp.edu/~faculty-affairs/
Faculty web site: http://www.cpp.edu/~seskandari/ GATMD: http://physiology.sci.cpp.edu/GATMD/
EDUCATION B.S. Chemistry 1993 Chemistry Department
California State Polytechnic University, Pomona M.S. Biology (Emphasis: Integrative Physiology) 1995 Biological Sciences Department
California State Polytechnic University, Pomona Mentor: Daniel F. Stiffler, Ph.D. Ph.D. Physiology 1999 Department of Physiology
School of Medicine University of California, Los Angeles (UCLA) Mentor: Ernest M. Wright, D.Sc. Post-Doctoral 1999 – 2000 Training Departments of Physiology and Neurobiology
School of Medicine University of California, Los Angeles (UCLA)
Mentors: Guido A. Zampighi, Ph.D. and Ernest M. Wright, D.Sc.
PROFESSIONAL EXPERIENCE 08/2016 – Present Interim Associate Vice President, Academic Planning & Faculty Affairs California State Polytechnic University, Pomona Pomona, CA 91768 06/2015 – 08/2016 Chair Academic Senate California State Polytechnic University, Pomona Pomona, CA 91768 06/2014 – 06/2015 Vice Chair Academic Senate California State Polytechnic University, Pomona Pomona, CA 91768 01/2012 – 06/2015 Professor and Chair Biological Sciences Department California State Polytechnic University, Pomona Pomona, CA 91768 07/2011 – 12/2011 Professor and Interim Chair Biological Sciences Department California State Polytechnic University, Pomona Pomona, CA 91768 2010/2011 Professor and Associate Chair Biological Sciences Department California State Polytechnic University, Pomona Pomona, CA 91768 2010 – Present Professor Biological Sciences Department California State Polytechnic University, Pomona Pomona, CA 91768 2005 – 2010 Associate Professor Biological Sciences Department California State Polytechnic University, Pomona Pomona, CA 91768 2000 – 2005 Assistant Professor Biological Sciences Department
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 3 of 18
California State Polytechnic University, Pomona Pomona, CA 91768 MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS AND HONORARY SOCIETIES Current 1. American Association for the Advancement of Science (1996) 2. American Physiological Society (1995) 3. Society for Neuroscience (1995) 4. Golden Key National Honor Society (1992) Previous 1. American Society for Biochemistry and Molecular Biology (2003–2012) 2. Biophysical Society (1995–2002) 3. West Coast Salt and Water Club (1996–1999) HONORS AND AWARDS 1. Cal Poly Scholar Athlete of the Year, 1987 2. Vernon Gregory Memorial Scholarship Award, Biological Sciences Department, California
State Polytechnic University, Pomona, 1993/94 3. Biological Sciences Graduate Student Research Award, California State Polytechnic
University, Pomona, 1994/95 4. American Physiological Society Procter & Gamble Professional Opportunity Award, 1998 5. John Field Award, Department of Physiology, UCLA School of Medicine, 1998 6. Travel Grant; 1999 International Gap Junction Conference, Gwatt, Switzerland 7. Ahmanson Foundation Cellular Neurobiology Post-Doctoral Training Grant, Brain Research
Institute, UCLA, 1999/2000 8. College of Science Distinguished Teaching Award, California State Polytechnic University,
Pomona, 2005 9. Biotechnology Faculty Research Award, California State University Program for Education
and Research in Biotechnology (CSUPERB), 2011 10. Cal Poly Pomona Alumni Outstanding Teaching Award, 2016 11. Annual Student Affairs Partnership Award, Division of Student Affairs, California State
Polytechnic University, Pomona, 2016 RESEARCH FOCUS AND EXPERTISE
Research in this laboratory focuses on the brain -aminobutyric acid (GABA) transporters. These molecules are involved in the regulation of inhibitory neuronal signaling in the brain and, in
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 4 of 18
addition, are the targets of several important experimental and clinical drugs. Because GABA is the most abundant inhibitory neurotransmitter in the brain, the GABA transporters are implicated in the treatment of epileptic seizures, and in the control of the devastating consequences of stroke. Our goal is to elucidate a comprehensive understanding of GABA transporter structure and function. In addition, we are interested in the nature of drug interaction with the GABA transporters. Our functional experiments examine wild-type, chimeric, and mutant transporters and are designed with the goal of gaining a deeper understanding of the mechanism of transport cycle. The pharmacological experiments focus on identifying the minimum substrate structural features needed for recognition and translocation by the transporter. The long-term goal of the pharmacological studies is to identify/develop compounds that selectively target different isoforms of the GABA transporters found in different brain regions. Such research will pave the way for localized pharmacological treatment of epileptic seizures, stroke, and other pathophysiological conditions in which neurons enter hyper-excited states. Electrophysiological (two-electrode voltage clamp, patch clamp, ion-selective electrodes), molecular and cell biological (site-directed mutagenesis, western blots, etc.), imaging (light and fluorescence microscopy, thin section and freeze-fracture electron microscopy), as well as isotope methods are used to achieve these goals. TEACHING EXPERTISE 1. Transport across Cell Membranes 2. Electrophysiological Methods 3. Freeze-Fracture Electron Microscopy 4. Molecular and Cellular Physiology 5. Animal Physiology 6. Human Physiology 7. Endocrinology 8. Radiation Biology 9. Biophysics 10. Introductory Biology RESEARCH GRANTS
1. Molecular physiology of -aminobutyric acid transporters. Principal Investigator. ($444,791 in direct and indirect costs). National Institutes of Health (S06 GM-53933). 2001–2004.
2. The effect of anti-epileptic drugs on the brain -aminobutyric acid transporters. ($5,000). Research, Scholarship, and Creative Activities Grant. California State Polytechnic University, Pomona. 2001.
3. The effect of anti-epileptic drugs on the brain -aminobutyric acid transporters ($750). Faculty Professional Development Mini-Grant. California State Polytechnic University, Pomona. 2001.
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 5 of 18
4. Equipment supplement to S06 GM-53933. Co-Principal Investigator. ($485,610). National Institutes of Health. 2002.
5. Molecular physiology of -aminobutyric acid transporters. Principal Investigator. ($640,727 in direct and indirect costs). National Institutes of Health (S06 GM-53933). 2004–2008.
6. Molecular physiology of -aminobutyric acid transporters. Principal Investigator. ($1,278,000 in direct and indirect costs). National Institutes of Health (SC1GM086344 from the National Institute of General Medical Sciences). 2009–2013.
7. Equipment supplement to SC1GM086344. Principal Investigator. ($39,282). National Institutes of Health (3SC1GM086344-01S1 from the National Institute of General Medical Sciences). 2009–2010.
8. Components of inhibitory signal transmission in bovine sperm. Principal Investigator. ($50,000). California State University Agricultural Research Initiative. 2011–2012.
9. Role of -aminobutyric acid (GABA) transporters in bovine sperm physiology. Principal Investigator. ($72,900). California State University Agricultural Research Initiative. 2013–2014.
10. Mechanistic studies of the brain -aminobutyric acid transporters ($10,000). Research, Scholarship, and Creative Activities Grant. California State Polytechnic University, Pomona. 2016.
11. Small Business Innovation Research (SBIR): Inhibition of HCN Channels in the Inner Retina Enhances Visual Function: A Potential Therapeutic Target to Reverse Vision Loss in Patients with Mild to Moderate Retinal Neurodegenerative Disorders. Academic Partner. (Sub-award to Cal Poly Pomona: $53,618.17). National Eye Institute of the National Institutes of Health. Pending.
TEACHING GRANTS
1. Data Acquisition and Analysis in the Modern Physiology Teaching Laboratory. ($20,000). Funding obtained from California State University Program for Education and Research in Biotechnology (CSUPERB). 2000–2001.
2. Electrophysiological Screening of Drugs in Xenopus laevis Oocytes. ($20,000). Funding obtained from California State University Program for Education and Research in Biotechnology (CSUPERB). 2001–2002.
GRANTS Related to the Advancement of Department, College, and University 1. Kellogg Distinguished Public Lecture Series. Project Director. ($275,000). Kellogg Legacy
Project Endowment. 2011/12, 2012/13, 2013/14, and 2014/15 academic years. 2. Special Projects for Improving the Classroom Experience Program (SPICE). ($18,611.85).
Audiovisual Equipment for Four Teaching Laboratory Classrooms in the Biological Sciences Department. California State Polytechnic University, Pomona. 2014/2015 academic year.
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 6 of 18
PUBLICATIONS The number of times a publication has been cited is shown in brackets (updated January 2016). * Undergraduate student co-author ** Graduate student co-author Original Articles Papers Published 1. Stiffler, D.F., Eskandari, S. (1994) Blood-gas, acid-base and catecholamine responses to
lactic acid infusion in larval and adult Ambystoma tigrinum. J. Comp. Physiol. B 164, 355–361. [2]
2. Eskandari, S., Stiffler, D.F. (1997) Interrenal function in larval Ambystoma tigrinum. IV. Acid–base balance and the renin–angiotensin system. Gen. Comp. Endocrinol. 105, 18–30. [1]
3. Stiffler, D.F., Eskandari, S., Dejbakhsh, S. (1997) Cutaneous transport of Ca2+ in the frog Rana pipiens: Significance and specificity. J. Exp. Zool. 277, 371–381. [11]
4. Panayotova-Heiermann, M., Eskandari, S., Turk, E., Zampighi, G.A., Wright, E.M. (1997) Five transmembrane helices form the sugar pathway through the Na+/glucose cotransporter. J. Biol. Chem. 272, 20324–20327. [71]
5. Eskandari, S., Loo, D.D.F., Dai, D., **Levy, O., Wright, E.M., Carrasco, N. (1997) Thyroid Na+/I– symporter: Mechanism, stoichiometry, and specificity. J. Biol. Chem. 272, 27230–27238. [288]
6. Eskandari, S., Wright, E.M., Kreman, M., Starace, D.M., Zampighi, G.A. (1998) Structural analysis of cloned plasma membrane proteins by freeze-fracture electron microscopy. Proc. Natl. Acad. Sci. USA 95, 11235–11240. [145]
7. Marvizón, J.-C.G., Eskandari, S., Ennes, H.S., Mayer, E.A. (1998) Substance P induces brief, localized increases in [Ca2+]i in dorsal horn neurons. NeuroReport 9, 3369–3374. [9]
8. Zampighi, G.A., Loo, D.D.F., Kreman, M., Eskandari, S., Wright, E.M. (1999) Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes. J. Gen. Physiol. 113, 507–523. [91]
9. Forster, I.C., Loo, D.D.F., Eskandari, S. (1999) Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters. Am. J. Physiol. 276 (Renal Physiol. 45), F644–F649. [69]
10. Eskandari, S., Snyder, P.M., Kreman, M., Zampighi, G.A., Welsh, M.J., Wright, E.M. (1999) Number of subunits comprising the epithelial sodium channel. J. Biol. Chem. 274, 27281–27286. [96]
11. **Weeks, D.L., Eskandari, S., Scott, D.R., Sachs, G. (2000) A H+ gated urea channel: The link between Helicobacter pylori urease and gastric colonization. Science 287, 482–485. [260]
12. Rektorschek, M., Buhmann, A., Weeks, D., Schwan, D., Bensch, K.W., Eskandari, S., Scott, D., Sachs, G., Melchers, K. (2000) Acid resistance of Helicobacter pylori depends on the UreI membrane protein and an inner membrane proton barrier. Mol. Microbiol. 36, 141–152. [54]
13. Eskandari, S., Kreman, M., Kavanaugh, M.P., Wright, E.M., Zampighi, G.A. (2000) Pentameric assembly of a neuronal glutamate transporter. Proc. Natl. Acad. Sci. USA 97, 8641–8646. [100]
14. Turk, E., Kim, O., le Coutre, J., Whitelegge, J.P., Eskandari, S., *Lam, J.T., Kreman, M., Zampighi, G.A., Faull, K.F., Wright, E.M. (2000) Molecular characterization of Vibrio
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 7 of 18
parahaemolyticus vSGLT: A model for sodium-coupled sugar cotransporters. J. Biol. Chem. 275, 25711–25716. [65]
15. Zampighi, G.A., Eskandari, S., Kreman, M. (2000) Epithelial organization of the mammalian lens. Exp. Eye Res. 71, 415–435. [67]
16. Loo, D.D.F., Eskandari, S., Boorer, K.J., Sarkar, H.K., Wright, E.M. (2000) Role of chloride in electrogenic Na+-coupled cotransporters GAT1 and SGLT1. J. Biol. Chem. 275, 37414–37422. [88]
17. Diez-Sampedro, A., Eskandari, S., Wright, E.M., Hirayama, B.A. (2001) Na+-to-sugar stoichiometry of SGLT3. Am. J. Physiol. Renal Physiol. 280, F278–F282. [25]
18. Eskandari, S., Zampighi, G.A., *Leung, D.W., Wright, E.M., Loo, D.D.F. (2002) Inhibition of gap junction hemichannels by chloride channel blockers. J. Membr. Biol. 185, 93–102. [100]
19. Mischel, P.S., Umbach, J.A., Eskandari, S., **Smith, S.G., Gundersen, C.B., Zampighi, G.A. (2002) Nerve growth factor signals via preexisting TrkA receptor oligomers. Biophys. J. 83, 968–976. [26]
20. **Sacher, A., Nelson, N., **Ogi, J.T., Wright, E.M., Loo, D.D.F., Eskandari, S. (2002)
Presteady-state and steady-state kinetics, and turnover rate of the mouse -aminobutyric acid transporter (mGAT3). J. Membr. Biol. 190, 57–73. [23]
21. Zampighi, G.A., Eskandari, S., Hall, J.E., Zampighi, L., Kreman, M. (2002) Micro-domains of AQP0 in lens equatorial fibers. Exp. Eye Res. 75, 505–519. [49]
22. Zampighi, G.A., Kreman, M., Lanzavecchia, S., Turk, E., Eskandari, S., Zampighi, L., Wright, E.M. (2003) Structure of functional single AQP0 channels in phospholipid membranes. J. Mol. Biol. 325, 201–210. [18]
23. **Whitlow, R.D., **Sacher, A., Loo, D.D.F., Nelson, N., Eskandari, S. (2003) The
anticonvulsant valproate increases the turnover rate of -aminobutyric acid transporters. J. Biol. Chem. 278, 17716–17726. [22]
24. Gordon, L.M., Mobley, P.W., *Lee, W., Eskandari, S., *Kaznessis, Y.N., Sherman, M.A., Waring, A.J. (2004) Conformational mapping of the N-terminal peptide of HIV-1 gp41 in lipid detergent and aqueous environments using 13C-enhanced Fourier transform infrared spectroscopy. Protein Sci. 13, 1012–1030. [38]
D.D.F., Nelson, N., Eskandari, S. (2005) Novel properties of a mouse -aminobutyric acid transporter (GAT4). J. Membr. Biol. 203, 65–82. [28]
26. Eskandari, S., Wright, E.M., Loo, D.D.F. (2005) Kinetics of the reverse mode of the Na+/glucose cotransporter. J. Membr. Biol. 204, 23–32. [31]
27. **Cohen-Kfir, E., **Lee, W., Eskandari, S., Nelson, N. (2005) Zinc inhibition of -aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission. Proc. Natl. Acad. Sci. USA 102, 6154–6159. [48]
28. **Meyer, A., Eskandari, S., Grallath, S., Rentsch, D. (2006) AtGAT1, a high affinity
transporter for -aminobutyric acid in Arabidopsis thaliana. J. Biol. Chem. 281, 7197–7204. [44]
29. **Paroder, V., **Spencer, S.R., *Paroder, M., Arango, D., Schwartz, S., Mariadason, J.M., Augenlicht, L.H., Eskandari, S., Carrasco, N. (2006) Na+/Monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT. Proc. Natl. Acad. Sci. USA 103, 7270–7275. [67]
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 8 of 18
30. Livesay, D.R., **Kidd, P.D., Eskandari, S., Roshan, U. (2007) Assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: A case study analyzing the neurotransmitter/Na+ symporter family. BMC Bioinformatics 8, 397. [5]
Eskandari, S. (2007) Turnover rate of the -aminobutyric acid transporter GAT1. J. Membr. Biol. 220, 33–51. [14]
32. Gordon, L.M., *Nisthal, A., **Lee, A.B., Eskandari, S., Ruchala, P., Jung, C.L., Waring, A.J., Mobley, P.W. (2008) Structural and functional properties of peptides based on the N-terminus of HIV-1 gp41 and the C-terminus of the amyloid-beta protein. Biochim. Biophys. Acta 1778, 2127–2137. [12]
33. **Matthews, E. Jr., *Rahnama-Vaghef, A., Eskandari, S. (2009) -aminobutyric acid transporter 1 (GAT1) do not reveal a channel mode of conduction. Neurochem. Int. 55, 732–740. [4]
35. **Paroder-Belenitsky, M., **Maestas, M.J., Dohán, O., Nicola, J.P., Reyna-Neyra, A., Follenzi, A., Dadachova, E., Eskandari, S., Amzel, L.M., Carrasco, N. (2011) Mechanism of anion selectivity and stoichiometry of the Na+/I– symporter (NIS). Proc. Natl. Acad. Sci. USA 108, 17933–17938. [16]
G., **Anderson, C.M., Eskandari, S. (2012) Sulfhydryl modification of the -aminobutyric acid transporter 1 (GAT1) at a single solvent-exposed cysteine residue. J. Membr. Biol. 245, 841–857. [3]
37. **Willford, S.L., **Anderson, C.M., **Spencer, S.R., Eskandari, S. (2015) Evidence for a revised ion/substrate coupling stoichiometry of GABA transporters. J. Membr. Biol. 248, 795–810. [0]
**Gonzales, A.L., Eskandari, S. An improved method for concentration jumps around intact, voltage-clamped Xenopus laevis oocytes. J. Neurosci. Methods Submitted.
2. **Willford, S.L., **Anderson, C.M., Eskandari, S. Revised ion/substrate coupling stoichiometry of GABA transporters. In Glial Amino Acid Transporters, Advances in Neurobiology. Invited book chapter. Submitted.
Manuscripts In Preparation: Review Articles and Book Chapters
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 9 of 18
1. Wright, E.M., Loo, D.D.F., Panayotova-Heiermann, M., Hirayama, B.A., Turk, E., Eskandari, S., Lam, J. (1998) Structure and function of the Na+/glucose cotransporter. Acta Physiol. Scand. 163 (Suppl. 643), 257–264. [46]
2. Eskandari, S., Zampighi, G.A. (2000) Properties of connexin50 hemichannels expressed in Xenopus laevis oocytes. In Gap Junctions. Molecular Basis of Cell Communication in Health and Disease. Current Topics in Membranes. Vol. 49, ed. C. Peracchia, pp. 369–388. [2]
3. Loo, D.D.F., Eskandari, S., Hirayama, B.A., Wright, E.M. (2002) A kinetic model for secondary active transport. In Membrane Transport and Renal Physiology. The IMA Volumes in Mathematics and its Applications. Eds. H. E. Layton and A. M. Weinstein, Springer-Verlag,
pp. 6583. [0] 4. Eskandari, S. (2009) Remarkable commonalities of electrogenic and electroneutral
Na+/phosphate cotransporters. J. Physiol. 587, 4131–4132. [2] Abstracts and Presentations 1. Eskandari, S., Stiffler, D.F. (1993) A role for the renin–angiotensin system in acid–base
balance in Ambystoma tigrinum. American Society of Zoologists meeting, Los Angeles, California. Am. Zool. 33, 44A.
2. Eskandari, S., Stiffler, D.F. (1994) Recovery of Ambystoma tigrinum from lactacidosis during B1 and B2 blockade. Experimental Biology 94, Anaheim, California. FASEB J. 8, A574.
3. Eskandari, S., Dejbakhsh, S., Stiffler, D.F. (1995) Responses of frog skin (Rana pipiens) Ca2+ transport to alterations in Ca2+ balance. Experimental Biology 95, Atlanta, Georgia. FASEB J. 9, A355.
4. Eskandari, S., Toro, L., Stefani, E. (1996) Effect of chemical modification on the gating and ionic currents of the Shaker potassium channel. Biophysical Society meeting, Baltimore, Maryland. Biophys. J. 70, A189.
5. Eskandari S., Loo, D.D.F., Carrasco, N., Wright, E.M. (1996) Substrate Selectivity of the rat thyroid Na+/I– cotransporter. Annual meeting of the West Coast Salt and Water Club, Morro Bay, California.
6. Eskandari, S., Marvizon, J.C., Ennes, H.S., Lembo, T., Mayer, E.A. (1996) Desensitization of calcium responses of cultured rat dorsal horn neurons to substance P. Annual meeting of the American Gastroenterological Association, San Francisco, California. Gastroenterology 110, A1070.
7. Eskandari S., Zampighi, G.A., Carrasco, N., Wright, E.M. (1997) Identification of the Na+/I– cotransporter in the plasma membrane of Xenopus laevis oocytes. Annual meeting of the West Coast Salt and Water Club, Morro Bay, California.
8. Eskandari, S., Loo, D.D.F., Dai, G., **Levy, O., Carrasco, N., Zampighi, G.A., Wright, E.M. (1997) Characterization of the rat thyroid Na+/I– Symporter. Gordon Conference: Molecular Mechanisms of Membrane Transport Proteins. Plymouth, New Hampshire.
9. Eskandari, S., Kreman, M., Wright, E.M., Zampighi, G.A. (1998) Determination of the oligomeric assembly of integral membrane proteins. Experimental Biology 98, San Francisco, California. FASEB J. 12, A1013.
10. Wright, E.M., Hirayama, B.A., Loo, D.D.F., Turk, E., Panayotova-Heiermann, M., Eskandari, S. (1999) Principles of solute/Na+ transporters. International Meeting on Universal Principles of Pro- and Eukaryotic Membrane Transport. Osnabruck, Germany.
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 10 of 18
11. Eskandari, S., Loo, D.D.F., Wright, E.M. (1999) Functional asymmetry of the sodium/glucose cotransporter. Experimental Biology 99, Washington, D.C. FASEB J. 13, A399.
12. Eskandari, S., Loo, D.D.F., Kreman, M., Wright, E.M., Zampighi, G.A. (1999) Unitary properties and trafficking of connexin50 expressed in Xenopus laevis oocytes. 1999 International Gap Junction Conference, Gwatt, Zwitzerland.
13. Eskandari, S., Loo, D.D.F., *Leung, D.W., Zampighi, G.A., Wright, E.M. (2000) Inhibition of lens gap junction hemichannels by chloride channel blockers. Biophysical Society meeting, New Orleans, Louisiana. Biophys. J. 78, A319.
14. Eskandari, S., Kreman, M., Kavanaugh, M.P., Wright, E.M., Zampighi, G.A. (2000) Pentameric assembly of a neuronal glutamate transporter. Annual meeting of the West Coast Salt and Water Club, Morro Bay, California.
15. Eskandari, S., Loo, D.D.F., Boorer, K.J., Sarkar, H.K., Wright, E.M. (2000) Role of Cl– in the Na+/Cl–/GABA cotransporter. Experimental Biology 2000, San Diego, California. FASEB J. 14, A350.
16. Loo, D.D.F., Eskandari, S., **Meinild, A.-K., Wright, E.M. (2000) Water and urea transport by the plant H+/amino acid cotransporter. Experimental Biology 2000, San Diego, California. FASEB J. 14, A350.
17. Eskandari, S., **Sacher, A., Loo, D.D.F., Nelson, N. (2001) Functional characterization of the
mouse -aminobutyric acid transporter (GAT3). Society for Neuroscience, San Diego, California.
18. Mischel, P.S., Umbach, J.A., Eskandari, S., **Smith, S.G., Gundersen, C.B., Zampighi, G.A. (2001) Do TrkA receptors dimerize in response to NGF? Society for Neuroscience, San Diego, California.
19. Zampighi, G.A., Eskandari, S., Hall, J.E., Zampighi, L., Kreman, M. (2002) Arrangement of AQP0 in the lens: One protein many functions. Biophysical Society meeting, San Francisco, California. Biophys. J. 82, 210a.
20. **Whitlow, R.D., **Sacher, A., Loo, D.D.F., Nelson, N., Eskandari, S. (2002) Stimulation of
the -aminobutyric acid transporter (GAT3) by the anticonvulsant valproate. Experimental Biology 2002, New Orleans, Louisiana.
21. **Karakossian, M.H., **Ogi, J.T., **Sacher, A., Loo, D.D.F., Nelson, N., Eskandari, S. (2002)
Presteady-state and steady-state kinetic properties of the -aminobutyric acid transporter GAT4. Experimental Biology 2002, New Orleans, Louisiana.
22. **Padilla, O.R., **Spencer, S.R., **Sacher, A., Loo, D.D.F., Nelson, N., Eskandari, S. (2002)
Formulation of a substrate pharmacophore for the -aminobutyric acid transporters (GAT3 and GAT4). Society for Neuroscience, Orlando, Florida.
23. **Spencer, S.R., Eskandari, S. (2003) Determinants of electrogenicity in -aminobutyric acid transporters. Experimental Biology 2003, San Diego, California.
24. **Gomez, A.Q., **Lee, W., *Errico, M.J., Eskandari, S. (2003) Ion and substrate
concentration jumps at the -aminobutyric acid transporter. Society for Neuroscience, New Orleans, Louisiana.
25. **Lee, W., *Oropeza, R.A., *Ford, E.R., Eskandari, S. (2004) Turnover rates of -aminobutyric acid transporters. Experimental Biology 2004, Washington, D.C.
26. **Gomez, A.Q., **Lee, W., **Chapman, J.V., *Errico, M.J., Loo, D.D.F., Eskandari, S. (2004) A novel method for rapid concentration jumps around intact, voltage-clamped Xenopus laevis oocytes. Experimental Biology 2004, Washington, D.C.
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 11 of 18
27. **Spencer, S.R., Eskandari, S. (2004) Uncoupled cation and anion permeation through the
mouse -aminobutyric acid transporter mGAT4. Society for Neuroscience, San Diego, California.
28. Mobley, P.W, Perez-Munoz, L., *Nisthal, A., **Gonzales, A.L., Eskandari, S., Waring, A.J., Gordon, L.M. (2005) Effects of sequential proline substitutions on the ‘amyloid’ properties of the HIV-1 fusion peptide. 19th American Peptide Society Symposium, San Diego, California.
29. **Meyer, A., Eskandari, S., Rentsch, D. (2005) AtGAT1, a high affinity GABA transporter from Arabidopsis thaliana. 14th Swiss Plant Molecular Biology and Cell Biology Conference, Les Diablerets, Switzerland.
30. *Nisthal, A., *Lee, A.B., **Gonzales, A.L., Eskandari, S., Waring, A.J., Gordon, L.M., Mobley, P.W. (2005) Comparative structural and functional studies on peptides based on the HIV-1 fusion domain and the amyloid beta protein. Protein Society Meeting, Boston, Massachusetts.
31. **Gonzales, A.L., **Lee, W., **Spencer, S.R., **Oropeza, R.A., *Ford, E.R., Eskandari, S.
(2005) Turnover rate of the -aminobutyric acid transporter GAT1. Society for Neuroscience, Washington, D.C.
32. Mobley, P.W., *Nisthal, A., *Lee, A., Julius, J., Eskandari, S., Waring, A.J., Gordon, L.M. (2006) Comparative structural and functional studies on peptides based on the N-terminal HIV-1 fusion domain and the amyloid β-protein. Protein Society Meeting, San Diego, California.
evoked by rapid application of Na+ and GABA to the -aminobutyric acid transporter GAT4. Society for Neuroscience, Atlanta, Georgia.
34. Livesay, D.R., **Kidd, P.D., Eskandari, S., Roshan, U. (2007) Assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: A case study analyzing the neurotransmitter/sodium symporter family. Society for Neuroscience, San Diego, California.
35. *Maestas, M.J., Dohán, O., **Paroder, M., Nicola, J.P., Eskandari, S., Carrasco, N. (2008) Residue at position 93 of the Na+/iodide symporter (NIS) plays a critical role in Na+/substrate coupled transport. Experimental Biology 2008, San Diego, California.
37. **Omoto, J.J., **Maestas, M.J., **Rahnama-Vaghef, A., **Anderson, C.M., Eskandari, S.
(2010) Functional consequences of sulfhydryl modification of the -aminobutyric acid transporter 1 (GAT1) at a single solvent-exposed cysteine residue. Society for Neuroscience, San Diego, California.
38. **Anderson, C.M., **Sanchez, R.V., Eskandari, S. (2011) A mutagenesis database prototype for Neurotransmitter:Sodium Symporters. Society for Neuroscience, Washington, D.C.
39. **Sanchez, R.V., **Anderson, C.M., Eskandari, S. (2012) Transient currents evoked by rapid extracellular application of cosubstrates to the GABA transporter GAT1. Society for Neuroscience, New Orleans, Louisiana.
40. **Willford, S.L., **Anderson, C.M., **Spencer, S.R., Eskandari, S. (2014) Revised ion/substrate coupling stoichiometry of GABA transporters. Society for Neuroscience, Washington, D.C.
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 12 of 18
COPYRIGHTS 1. Eskandari, S. Structural analysis of integral membrane proteins by freeze-fracture electron
microscopy. United States Copyright Office. Registration number: TX-4-993-822. Registration date: 11-8-1999.
2. Eskandari, S. Lecture Notes on Physiology. United States Copyright Office. Registration number: TXu-1-093-189. Registration date: 6-24-2003.
PATENTS 1. Nancy Carrasco, Monika Paroder, Matthew J. Maestas, and Sepehr Eskandari. Mutant NIS
protein and uses thereof. Application number: US2011/000703. Publication date: October 27, 2011.
INVITED PRESENTATIONS 1. Institute of Physiology, University of Zurich, Switzerland. September, 1999. 2. Department of Biology, California State University, San Bernardino. November, 1999. 3. Biological Sciences Department, California State Polytechnic University, Pomona. February,
2000. 4. Minority Biomedical Research Support Seminar Series, California State Polytechnic
University, Pomona. October, 2001. 5. Minority Biomedical Research Support Seminar Series, California State Polytechnic
University, Pomona. November, 2003. 6. Biological Sciences Seminar Series. Department of Biological Sciences, California State
University, Los Angeles. November, 2005. 7. On Teaching Physiology at Cal Poly Pomona. 6th Annual College of Science Award Seminar
for Teaching Excellence. California State Polytechnic University, Pomona. December, 2005. 8. Program in Biology, California State University, Channel Islands. March, 2006. 9. Basic Medical Sciences Seminar Series, College of Osteopathic Medicine of the Pacific,
Western University of Health Sciences. January, 2008. 10. Department of Biology, California State University, San Bernardino. October, 2008. 11. Science Lecture Series, Saddleback College, Mission Viejo, California. February, 2010. 12. Department of Biological Science, California State University, Fullerton. December, 2010. 13. 2011 Biotechnology Faculty Research Award Lecture. California State University
Biotechnology Symposium, Garden Grove, California. January, 2011. 14. Annual meeting of the American Association for Laboratory Animal Science (AALAS), San
Diego, California. October, 2011. 15. Biological Sciences Department, California State Polytechnic University, Pomona. March,
2012.
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 13 of 18
16. Equipment Management. United States Higher Education Global Education Program. College of the Extended University, California State Polytechnic University, Pomona. July, 2012.
17. College of Pharmacy, Western University of Health Sciences, May, 2013. FORMER RESEARCH TRAINEES This information was last updated in December 2015. SE refers to Sep Eskandari. 1. Dr. Movses H. Karakossian (PhD) completed an M.S. in Biology with SE (2000–2002),
completed a Ph.D. in Neurobiology at UCLA (2009), and is now a Scientist at Allergan. (Karakossian et al., 2005)
2. Dr. Erik B. Malarkey (PhD) was an undergraduate research student in SE’s lab (2001–2002), completed a Ph.D. in Cell, Molecular and Developmental Biology at the University of California, Riverside (2007), and is now a post-doctoral fellow at the University of Alabama at Birmingham.
3. Mr. Richard D. Whitlow, Esquire (MS) completed an M.S. in Biology with SE (2000–2002), completed a J.D. at Chapman College (2003), and is now patent lawyer with Jones Day (Irvine, CA). (Whitlow et al., 2003)
4. Dr. Blake W. Scott (DDS) was an undergraduate research assistant in SE’s lab (2002–2003), completed a DDS at University of the Pacific School of Dentistry (2006), and is now in private practice (Fresno, CA).
5. Dr. Evelyn (Becky) Ford (MD) was a student at Pomona College who joined the SE lab as an undergraduate research student (2002–2003). She completed her senior thesis in the SE’s lab. She obtained an MD from Oregon Health and Science University School of Medicine, and is now in Internal Medicine residency at Columbia University Medical Center.
6. Dr. Paul M. Ruegger (PhD) was an undergraduate research student in SE’s lab (2002–2003), completed a Ph.D. in Genetics, Genomics & Bioinformatics at the University of California, Riverside (2011), and is now a post-doctoral fellow at the University of California, Riverside.
7. Mr. Oscar R. Padilla (MS) completed an M.S. in Biology with SE (2001–2003), and is now a research associate at Long Beach VA Medical Center in Long Beach, California. (Karakossian et al.,
2005) 8. Mr. Michael J. Errico (BS) was an undergraduate research student in SE’s lab (2001–2004),
and is now research and development engineer working for Interlink Electronics (Camarillo, CA).
9. Dr. William Lee (PhD) was both an undergraduate (2001–2003) and graduate research student (2003–2005) in SE’s lab, completed an M.S. in Biology with SE (2005), completed a Ph.D. in Neuroscience at the University of California, Riverside (2010), and is now a post-doctoral fellow at the University of Alabama at Birmingham. (Gordon et al., 2004; Cohen-Kfir et al., 2005;
Gonzales et al., 2007) 10. Dr. Adrian Q. Gomez (DO) completed an M.S. in Biology with SE (2003–2005), completed a
D.O. at the College of Osteopathic Medicine of the Pacific (2010), and is now in Emergency Medicine residency (Kingman, AZ). (Karakossian et al., 2005)
11. Dr. Gail M. Drus (PhD) was an undergraduate research student in SE’s lab (2001–2005), completed an M.S. in Biology at Cal Poly Pomona (2005), completed a PhD Ecology,
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 14 of 18
Evolution, and Marine Biology at the University of California, Santa Barbara (2013), and is now an Assistant Professor of Biology at Saint Francis University.
12. Dr. Aaron D. Cossette (DO) was an undergraduate research student in SE’s lab (2005–2006), completed a D.O. at Touro University College of Osteopathic Medicine (2010).
13. Dr. Albert L. Gonzales (PhD) completed an M.S. in Biology with SE (2004–2006), completed a Ph.D. in Neuroscience at Colorado State University, and is now a post-doctoral fellow at the University of Vermont. (Gonzales et al., 2007; Sanchez et al., submitted)
14. Ms. Jackie V. Chapman (MS) completed an M.S. in Biology with SE (2004–2006), and is now a research associate at the Beckman Institute at University of California, San Diego. (Gonzales et
al., 2007) 15. Ms. Shelly R. Spencer (MS) was both an undergraduate (2001) and graduate research
student (2001–2003) in SE’s lab, completed an M.S. in Biology with SE (2003), and is now a faculty member in the Biology Department at Rio Hondo Community College (Whittier, CA). (Karakossian et al., 2005; Paroder et al., 2006; Gonzales et al., 2007)
16. Dr. Jerry Y. Ku (PharmD) was an undergraduate research student in SE’s lab (2005–2007), completed a Pharm.D. at the University of Southern California (2011), and is now a pharmacists for CVS (Bakersfield, CA). (Gonzales et al., 2007)
17. Mr. Raymond A. Oropeza (MS) completed an M.S. in Biology with SE (2005–2007), and is now a faculty member in the Biology Department at Citrus Community College (Glendora, CA). (Gonzales et al., 2007; Sanchez et al., submitted)
18. Mr. Patrick D. Kidd (MS) completed an M.S. in Biology with SE (2005–2007), and is now a lecturer in the Biological Sciences Department at California State Polytechnic University, Pomona. (Livesay et al., 2007)
19. Ms. Rana Moosavi (MS) completed an M.S. in Biology with SE (2007–2009) and is now pursuing an M.D.
20. Mr. Edward Matthews, Jr. (MS) completed an M.S. in Biology with SE (2007–2009). (Matthews
et al., 2009) 21. Mr. Jaison J. Omoto (MS) completed an M.S. in Biology with SE (2008–2010), and is now
pursuing a Ph.D. at UCLA. (Omoto et al., 2012) 22. Mr. Ali Rahnama-Veghef (BS) was an undergraduate and graduate research student in SE’s
lab (2009–2011), and is now pursuing a DPM (Doctor of Podiatric Medicine) at Temple University (Philadelphia, PA). (Matthews et al., 2009; Omoto et al., 2012)
23. Mr. Matthew J. Maestas (BS) was an undergraduate and graduate research student in SE’s lab (2009–2011), and is now a physical therapist. (Paroder-Belenitsky et al., 2011; Omoto et al., 2012)
24. Ms. Ye Esther Choi was a summer undergraduate research student in SE’s lab (2010–2011), and went on to complete a BS in Physiological Science at UCLA. (Omoto et al., 2012)
25. Ms. Cynthia M. Anderson (MS) completed an M.S. in Biology with SE (2010–2012), and is now a lecturer and faculty advisor in the Biological Sciences Department at California State Polytechnic University, Pomona. (Anderson et al., 2010; Omoto et al., 2012; Sanchez et al., submitted)
26. Ms. Rachel V. Sanchez (MS) was both an undergraduate (2009–2011) and graduate research student in SE’s lab (2011–2013), and is now pursuing a Ph.D. at Drexel University. (Omoto et al., 2012; Sanchez et al., submitted)
27. Ms. Samantha L. Willford (MS) completed an M.S. in Biology with SE (2013–2015), and is now a first-year medical student at Sackler School of Medicine. (Willford et al., 2015; Sanchez et al.,
submitted)
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 15 of 18
SERVICE Service to the Biological Sciences Department 1. Department Chair, Biological Sciences Department, California State Polytechnic University,
Pomona (01/2012–06/2015) 2. Interim Department Chair, Biological Sciences Department, California State Polytechnic
University, Pomona (07/2011–12/2011) 3. Associate Chair, Biological Sciences Department, California State Polytechnic University,
Pomona (09/2010 to 06/2011) 4. Standing Departmental Committees
a. Biological Sciences Department Long-Range Planning Committee, Member (2000–2005); Chair (2003–2005)
b. Zoology Major Committee, Member (2001–2016); Chair (2003–2008) c. Department Advisory Committee, Elected member (2006–2008), ex-officio (2010–2011) d. Executive Advisory Committee, Member (2003–2006) e. Health and Safety Committee, Member (2003–2008) f. Biotechnology Major Committee, Member (2002–2008) g. Curriculum Committee, Member (2002–2008) h. Scheduling Committee, Member (2003/2004) i. Microscopy (Imaging) Committee, Member (2002–2010) j. Facilities Committee, Member (2004–2006) k. Seminar Committee, Member (2002/2003) l. Biological Sciences Department Reappointment, Tenure, and Promotion Committee
(DRTPC), Member (2005/2006; 2006/2007; 2008/2009; 2009/2010) m. Biological Sciences Department Award for Teaching Excellence Committee, Chair
(2006/07; 2007/08; 2008/09), Member (2011/2012, 2012/2013) n. Biological Sciences Department Scheduling Coordinator (Fall 2010 to Summer 2015) o. Biological Sciences Department Assessment Committee (Fall 2010 to Summer 2015) p. Lecturer Assessment Committee, Member (2010/2011) q. Biological Sciences Department Faculty Research Award Committee, Chair (2012–2015) r. Biological Sciences Department Staff Excellence Award Committee, Chair (2012–2015) s. Biological Sciences Department Student Awards Committee, Member (2012–2015) t. Faculty Workload Committee, Member (2011/2012) u. Space Policy Committee, Member (2011/2012)
5. Departmental Search Committees a. Biology Educator Search Committee, Member (2000/2001) b. Neurophysiology Search Committee, Member (2001/2002) c. Developmental Biology Search Committee, Member (2002/2003) d. Bioinformatics Search Committee, Co-Chair (2003/2004) e. Bioinformatics Search Committee, Chair (2004/2005) f. Chair Search Committee, Co-Chair (2005/2006) g. Business Operations Specialist Search Committee, Member (2006) h. Physiological Genomics Search Committee, Chair (Fall 2008)
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 16 of 18
i. Organismal Biology Instructional Support Technician Search Committee, Chair (2013) j. Physiology Search Committee, Co-Chair (2015/2016)
6. Departmental Task Forces and/or Ad Hoc Committees a. Task Force to Provide Junior Faculty Input to the new Departmental RTP Document,
Coordinator (2003) b. Nominating Task Force to select RTP Committee Members, Member (2004/05, 2005/06) c. Department Staffing Task Force, Member (2005) d. Department Chair Review Committee, Chair (2005) e. Student Survey Task Force, Member (2005) f. Market/Equity Salary Committee (2007) g. Lecturer Range Evaluation Committee (2007) h. Task Force to Provide Recommendations to I&IT Regarding Upgrades to Rooms 3-215
and 3-217, Chair (April 2008) i. Hiring Plan Task Force, Chair (May 2009)
7. Faculty Advisory Roles a. Faculty Advisor for the Physiology Minor (2001–2016) b. Faculty Advisor to Zoology Majors (2001–2016) c. Faculty Advisor for the Pre-Dent Society (2003–2005) d. Four-Year Graduation Pledge advisor for Zoology students (2003–2012) e. Science Educational Enhancement Services (SEES) advisor (2007–2016) f. Internship Coordinator (Biology and Environmental Biology Majors) (2010–2011)
Service to the College of Science 1. Academic Senate, College of Science Senator (2009–2012, 2013–2016) 2. College of Science Distinguished Teaching Award Committee, Member (2005–2007, 2012);
Chair (2006/07) 3. College of Science Mission Statement Working Group, Chair (2008/09) 4. Search Committee, Dean of the College of Science, Chair (2010/11) 5. Search Committee, College of Science Associate Dean for Academics and Research, Chair
(2012/13) 6. Search Committee, College of Science Associate Dean for Operations and Budget, Member
(2012/13) Service to the University 1. Search Committee, Director for the Office of Research and Sponsored Programs, Member
(2005/06) 2. Cal Poly Pomona Institutional Animal Care and Use Committee (ACUC), Chair (2006–2008) 3. University Research Council; Elected Representative of the College of Science (2006/07 and
2007/08) 4. Search Committee, Director of Instructional and Information Technology (I&IT) Systems,
Member (2006/07) 5. University Radiation Safety Committee, Member (2008 to present)
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 17 of 18
6. Faculty Affairs Sub-Committee of the Academic Senate, Member (2008–2012) 7. University Outstanding Staff Award Committee, Member (2008/09, 2015/16) 8. Academic Senate, Senator (2009–2012, 2013–2016) 9. Management Performance Review Committee for the Associate Vice President for
Research, Chair (2010) 10. Search Committee, Associate Vice President for Academic Planning, Policy, and Faculty
Affairs, Member (2010/11) 11. Search Committee, Plant Science Department Chair, Member (2011/2012) 12. Kellogg Lectures Steering Committee, Chair (2011–2014) 13. University Council of Chairs, Member (2011–2015) 14. University Biosafety Committee, Member (2012–2014) 15. General Education Sub-Committee of the Academic Senate, Member (2013/2014) 16. Foundation Board of Directors, Faculty Representative (2013–2014) 17. Foundation Board of Directors, Director (2015–2016) 18. Student Success Fee Committee, Engagement with Academic Departments, Chair (2012–
2015) 19. Academic Senate, Vice-Chair (06/2014–06/2015) 20. Search Committee, Chief of Staff, Member (2015) 21. Search Committee, Chief of Police, Member (2015) 22. Academic Senate, Chair (2015/16, 2016/17 term to begin on June 20, 2016) 23. Semester Conversion Steering Committee, Member (2015–2016) 24. IT Governance Executive Committee, Member (2015–2016) 25. Presidential Investiture Committee, Member (2015/2016) 26. University Strategic Planning Steering Committee, Member (2016 to present) 27. Search Committee, Vice President for University Advancement, Chair (2016) 28. Campus Emergency Advisory Committee, Member (2016 to present) Service to the California State University System 1. Faculty Research Award Selection Committee, California State University Program for
Education and Research in Biotechnology (CSUPERB), Member (2014, 2015) 2. CSU Biology Council of Chairs, Member (2011–2015) 3. CSU Campus Senate Chairs Group, Member (2015–2016) Community Outreach Activities 1. 18th Annual Los Angeles County Science Olympiad (3-6-2004); Co-Captain (with Dr. Donald
F. Hoyt) for Science of Fitness Events for Divisions B (Middle School) and C (High School) 2. 20th Annual Southern California State Science Olympiad (5-1-2004); Co-Captain (with Dr.
Donald F. Hoyt) for Science of Fitness Events for Divisions B (Middle School) and C (High School)
3. 19th Annual Los Angeles County Science Olympiad (3-5-2005); Co-Captain (with Dr. Donald F. Hoyt) for Science of Fitness Event for Division B (Middle School) and Health Science Event for Division C (High School).
Curriculum Vitae – Sep Eskandari, Ph.D.
Page 18 of 18
4. 20th Annual Los Angeles County Science Olympiad (3-4-2006); Captain for Science of Fitness Event for Division B (Middle School).
5. Presentation and hands-on demonstration on microbes and microbial growth to students at Pantera Elementary School, Pomona Unified School District (4-10-2014)
Professional Service 1. Program reviewer
a. External reviewer of the Biology Department at a sister California State University (CSU) campus.
2. Peer-reviews have been conducted for the following journals: a. American Journal of Physiology – Cell Physiology b. Biophysical Journal c. Cellular and Molecular Life Sciences d. Future Medicinal Chemistry e. Journal of Biomolecular Structure and Dynamics f. Journal of Experimental Biology g. Journal of Membrane Biology h. Journal of Pharmacy and Pharmacology i. Journal of Physiology (London) j. Journal of Structural Biology k. Molecular Psychiatry l. Ophthalmic Plastic and Reconstructive Surgery m. Trends in Neurosciences n. UCSD - Nature Signaling Gateway
3. Peer-reviews have been conducted for the following book publishers: a. McGraw Hill
