Oklahoma’s innovative action to increase applied research and technology commercialization for more high-paying jobs and a strong, diversified economy

H.E. “Gene” Rainbolt, Chair, Chairman of the Board, BancFirst Corp (Governor Appointee)

Samuel Combs III, President, ONEOK Distribution Co (Pro Tempore Appointee)

Gary W. Derrick, Derrick & Briggs (Governor Appointee)

Ken Levit , Executive Director, George Kaiser Family Foundation (Pro Tempore Appointee)

Thomas C. Kupiec, Ph.D., President and CEO, Analytical Research Laboratories and DNA Solutions (Speaker Appointee)

Greg McKenzie, Attorney, Edmond, Oklahoma (Governor Appointee)

Bond Payne, Chairman of the Board, Heritage Trust (Speaker Appointee)

Paul G. Risser, Ph.D., Executive Director, EDGE Policy Board

 

EDGE Policy BoardEDGE Policy Board

EDGE legislation clearly defines EDGE legislation clearly defines targeted investment of the EDGE targeted investment of the EDGE fundsfunds(Title 62 O.S. Supp.2007 §47, §52)Requires one or more:

1. Expand directly the number of researchers, technicians and support services and associated activity with in Oklahoma.

2. Have a high potential to result in the formation and growth of advanced technology companies in Oklahoma.

3. Leverage of additional federal research grants and/or privately funded research in Oklahoma

research institutions.

4. Have a high potential to improve the health status and quality of life for Oklahoma

Federal R&D Funding $ RankTotal to Oklahoma $322 M 38Oklahoma per capita $91 45US per capita $364 25

Per capita R&D funding to Oklahoma as % of national average = 25%

If Oklahoma obtained federal R&D funding at the national per capita average, 3 X $322 M = $966,000,000 each yearpumped into the State’s economy

___________________American Association for the Advancement of Science (2007)

EDGE Policy Board

If Oklahoma captured more If Oklahoma captured more federal R&D funding… federal R&D funding…

EDGE Policy Board EDGE Policy Board MissionMissionTo make investments in Oklahoma’s knowledge infrastructure to

bolster the State’s long-term economic growth.

Some key concepts:• increase applied research and technology commercialization • eventually to yield more high-paying jobs

• a stronger, more diversified Oklahoma economy

• business sector priorities

• build capacity, attract external dollars

• relatively large dollar amounts, one to several years

• competitively approved projects. • public and private organizations

• preference for collaboration

EDGE Policy Board EDGE Policy Board OptionsOptions

Awards to “push” and “pull” research and technology

Many types of awards:• proof-of-concept• applied research• matching funds• purchase of equipment• seed capital• other

Many funding instruments:• grants• contracts• no-interest loans• supplementary• funds to existing programs• other approved forms

Operating Policies and ProceduresOperating Policies and Procedures

1. Areas of focus:

Aerospace, Agriculture, Biotechnology, Energy, Information Technology/Telecommunications, Nanotechnology, Sensors, Weather Science, Other

2. Specifications in requests for proposals:

- No minimum-maximum dollar amount

- Funding one year or more

- No indirect costs

- >25% technology commercialization

- <20% for equipment

- Prefer public-private collaboration

- Advisory Board

- Few projects

- Broad publicity

- Return on investment

EDGE Policy Board EDGE Policy Board Advisory CommitteeAdvisory Committee

State and National ExpertsOklahoma 3California 2Florida 1Mississippi 1North Carolina 1Ohio 2

Technical and Business Expertise aerospace, agriculture, biomedical, biotechnology, energy,

genomics, IT and computer science, weather science

High-tech investment at all stages, state research consortium, regional entrepreneurship program, state and federal funding programs

EDGE Advisory CommitteeEDGE Advisory CommitteeJ. Donald CapraJ. Donald Capra, M.D., (Chair), M.D., (Chair)

President Emeritus, Oklahoma Medical Research Foundation, OKPresident Emeritus, Oklahoma Medical Research Foundation, OK

Susan M. Bridges, Susan M. Bridges, Ph.D.Ph.D.

Co-Director, Institute for Digital Biology, Mississippi State UniversityCo-Director, Institute for Digital Biology, Mississippi State University

Leroy ChiaoLeroy Chiao, Ph.D., Ph.D.

Executive Vice President, Excalibur Almaz, Houston, TXExecutive Vice President, Excalibur Almaz, Houston, TX

Richard A. DixonRichard A. Dixon, D. Phil., D. Phil.

DSC, Senior Vice President, Samuel Roberts Noble Foundation, OKDSC, Senior Vice President, Samuel Roberts Noble Foundation, OK

Robert HinesRobert Hines, Ph.D., Ph.D.

President, tech Resources, Inc. Columbus, OHPresident, tech Resources, Inc. Columbus, OH

Robert McNeilRobert McNeil, Ph.D., Ph.D.

Managing Director, Sanderling Venture Partners, San Mateo, CAManaging Director, Sanderling Venture Partners, San Mateo, CA

William PaivaWilliam Paiva, Ph.D., Ph.D.

Manager, Oklahoma Life Science Fund, Sevin Rosen Funds, OKManager, Oklahoma Life Science Fund, Sevin Rosen Funds, OK

Duane RothDuane Roth, Ph.D., Ph.D.

Chief Executive Officer, CONNECT, San Diego, CA Chief Executive Officer, CONNECT, San Diego, CA

Warren QualleyWarren Qualley, Ph.D., Ph.D.

Senior Weather Engineer, Harris Corporation, Washington, DCSenior Weather Engineer, Harris Corporation, Washington, DC

Edward W. UngarEdward W. Ungar, Ph.D., Ph.D.

President, Taratec Corporation, Columbus, OHPresident, Taratec Corporation, Columbus, OH

EDGE Proposal Review EDGE Proposal Review ProcessProcess

StepsSteps

1. Pre-proposals (94)1. Pre-proposals (94)

2. Pre-proposals reviewed by Advisory Committee, Staff and Policy 2. Pre-proposals reviewed by Advisory Committee, Staff and Policy BoardBoard

3.3. Advisory Committee recommended 15 full proposals; Policy BoardAdvisory Committee recommended 15 full proposals; Policy Board

invited 19 proposalsinvited 19 proposals

4. Technical reviewers4. Technical reviewers

5. Advisory Committee selected 7 proposals for presentations;5. Advisory Committee selected 7 proposals for presentations;

recommended 5 projectsrecommended 5 projects

6. Policy Board approved 5 projects, set budget amounts6. Policy Board approved 5 projects, set budget amounts

Lead Organizations on Lead Organizations on ProposalsProposals

Businesses (9)Businesses (9)Charlesson, LLCCharlesson, LLCHyalose, LLCHyalose, LLCJK Autoimmunity, Inc. JK Autoimmunity, Inc. Nantiox, Inc.Nantiox, Inc.Ortho Care Innovations, LLCOrtho Care Innovations, LLCRigen, IncRigen, IncSelexys PharmaceuticalSelexys Pharmaceutical

Corporation Corporation Southwest NanotechnologiesSouthwest NanotechnologiesStrategic SolutionsStrategic Solutions

International, LLCInternational, LLCThe Chickasaw NationThe Chickasaw Nation

Research Organizations (2)Research Organizations (2)Oklahoma Medical Oklahoma Medical Research Foundation Research Foundation Presbyterian Health Presbyterian Health FoundationFoundation

Universities (8)Universities (8)Oklahoma State University Oklahoma State University (4)(4)University of Oklahoma (4)University of Oklahoma (4)

Oklahoma-Glyco-Manufacturing Center: Oklahoma-Glyco-Manufacturing Center: Going Global with Next-Gen Sugar-Based Going Global with Next-Gen Sugar-Based

Therapeutics Therapeutics Principal Investigator: Principal Investigator: Paul DeAngelisPaul DeAngelis

Institution: Hyalose, LLCInstitution: Hyalose, LLC

Business Sector: Business Sector: BiotechnologyBiotechnology

Funding: Funding: $687,609; $550,002$687,609; $550,002

ExplanationExplanation Hyalose--Cytovance Biologics alliance to co-develop the scale-up Hyalose--Cytovance Biologics alliance to co-develop the scale-up

production of sugar-based products; develop FDA-approved procedures production of sugar-based products; develop FDA-approved procedures and documentation. and documentation.

DNA, proteins, lipids and sugars are the major kinds of molecules in the DNA, proteins, lipids and sugars are the major kinds of molecules in the human bodyhuman body

Know that sugar molecules can signal (sugar code) function on other Know that sugar molecules can signal (sugar code) function on other cellscells

Sugars can be constructed in the laboratory to perform specified Sugars can be constructed in the laboratory to perform specified functionsfunctions

Produce glycosaminoglycan (GAG) molecules for evaluation, sale and Produce glycosaminoglycan (GAG) molecules for evaluation, sale and licensinglicensing

Sub-license materials to big pharmaceutical companiesSub-license materials to big pharmaceutical companies Produce low-cost materials for Oklahoma researchersProduce low-cost materials for Oklahoma researchers

Nanoparticle-Mediated Drug Delivery Nanoparticle-Mediated Drug Delivery for the Treatment of Ocular Diseasesfor the Treatment of Ocular Diseases

Principal Investigator: Jian-xing Ma

Institution: Charlesson, LLC

Business Sector: Biotechnology

Funding : $1,382,234; $1,498,797

Explanation Diabetic retinopathy, retinal swelling caused by vascular bleeding, major

complication from diabetes Charlesson has small molecule that significantly reduces retinal vascular

leakage and inflammation Molecule can be encapsulated in a nanoparticle for slow release over >100

days Can also be used to treat age-related macular degeneration Potential for nanoparticle encapsulation technology to be adapted to many

drug therapies Develop a nanoparticle formulation service for other researchers and

applications.

The Renewable EDGEThe Renewable EDGE

Principal Investigator: J. Scott Greene

Institutions: University of Oklahoma and Oklahoma State University

Business Sector: Weather Science

Funding: $996,395; $753,424

Explanation Project will develop geospatial technologies to meet the needs of the

wind and weather science industries and commercialize these products

Develop high-precision wind power assessments and forecast system Develop detailed and accurate estimates of wind density in Oklahoma Develop the geo-spatial tool, ZepherBox, a multi-scale interactive

information system Commercialize these products

Shape Engineering for Advanced Shape Engineering for Advanced Manufacturing (SEAM)Manufacturing (SEAM)

Principal Investigator: Principal Investigator: Skivakumar RamanSkivakumar Raman

Institution: Institution: University of OklahomaUniversity of Oklahoma

Business Sector: Business Sector: AerospaceAerospace

Funding: Funding: $1,500,000; $1,500,000$1,500,000; $1,500,000

ExplanationExplanation Combines university-centered research facility with a for-profit Combines university-centered research facility with a for-profit

corporationcorporation University of Oklahoma, Oklahoma State University, University of University of Oklahoma, Oklahoma State University, University of

TulsaTulsa Shape engineering methodologies through hardware and software Shape engineering methodologies through hardware and software

infrastructuresinfrastructures Product reconfiguration analysis, innovative metrology (precision Product reconfiguration analysis, innovative metrology (precision

measurement), life-cycle analysis, process plans and integrated measurement), life-cycle analysis, process plans and integrated logisticslogistics

Provide a central location for the world’s advanced shape engineering Provide a central location for the world’s advanced shape engineering and manufacturing equipment for assessment and testing servicesand manufacturing equipment for assessment and testing services

U.S. Air Force and commercial aerospace companies;U.S. Air Force and commercial aerospace companies;

Project RESTORED Project RESTORED (Research, Education, Science (Research, Education, Science andand Technology for Orthopedic Rehabilitation and Technology for Orthopedic Rehabilitation and

Economic Development)Economic Development)

Principal Investigator: David Boone

Institution: OrthoCare Innovations, LLC

Business Sector: Biotechnology

Funding: $800,000; $800,000

Explanation Assembles, fabricates and tests prosthetics and orthotics which it

sells to customers who fit patients Expand research, development and manufacturing capacity for

prosthetic devices in Oklahoma Own intellectual property plus license to technology from ORNL,

Hong Kong Polytechnic University; research funding from NIH and DoD

Create a multi-institutional Limb Restoration Institute to foster long-term links with national research institutions and for technology commercialization.

Research, Education, Science and Technology Research, Education, Science and Technology for Orthopedic Rehabilitation and Economic for Orthopedic Rehabilitation and Economic

DevelopmentDevelopmentDavid Boone, Ph.D., OrthoCare Innovations, LLCDavid Boone, Ph.D., OrthoCare Innovations, LLC

  Performance Benchmarks

November 1, 2009 Develop 14,000 sq. ft. of manufacturing capacityDevelop 14,000 sq. ft. of manufacturing capacity Bring 3 new advanced prosthetic technologies to marketBring 3 new advanced prosthetic technologies to market Create a prosthetic limb ISO testing laboratoryCreate a prosthetic limb ISO testing laboratory Create a research consortium for research and development, and for Create a research consortium for research and development, and for

technology commercializationtechnology commercialization  November 1, 2010 Bring 4 new advanced prosthetic technologies to marketBring 4 new advanced prosthetic technologies to market Host an international symposium on advanced prostheticsHost an international symposium on advanced prosthetics Create 30 new development and technology manufacturing jobsCreate 30 new development and technology manufacturing jobs Establish a non-profit Limb Restoration Institute with a Establish a non-profit Limb Restoration Institute with a

comprehensive program to improve life for amputeescomprehensive program to improve life for amputees

Research, Education, Science and Technology Research, Education, Science and Technology for Orthopedic Rehabilitation for Orthopedic Rehabilitation and Economic Developmentand Economic Development

David Boone, Ph.D., OrthoCare Innovations, LLCDavid Boone, Ph.D., OrthoCare Innovations, LLC

Impact ReportImpact Report                                                                                                                                          2009                    _ ____  2010 2009                    _ ____  2010

Number of new jobs created                       Number of new jobs created                                

Salary distribution of these jobsSalary distribution of these jobs                          

Number of jobs retained                                   Number of jobs retained                                   Salary distribution of these jobsSalary distribution of these jobs

                 

Other project-based grants/contracts      Other project-based grants/contracts      Dollars of capital raised                                Dollars of capital raised                                Revenue from intellectual property               Revenue from intellectual property               Patent Applications                                         Patent Applications                                         Patent Awards                                                 Patent Awards                                                 Revenue from gross sales                              Revenue from gross sales                              

2323$32K to $110K$32K to $110K

99$32K to $90K$32K to $90K

2 at $125K each2 at $125K each$1 million$1 million$4 million$4 million

3322

$7 million$7 million

5555$32K to $110K$32K to $110K

3232$32K to $110K$32K to $110K

3 at $150K each3 at $150K each$3 million$3 million$20 million$20 million

4433

$23 million$23 million

EDGE After One YearEDGE After One Year

Year 2008

Widespread interest

Merit-based process

Proposed R&D praised by Advisory Committee

Year 2009

Begin measuring ROI

Responsive to Oklahoma industries

Additional funding instruments

2009 Policy Board Schedule of 2009 Policy Board Schedule of EventsEvents

January 20th EDGE Policy Board meeting to decide annual schedule

April 7th Policy Board meeting to decide parameters of annual

investment program

July 15th Policy Board meeting to decide on formal proposal

solicitations

November 10th Policy Board meeting to decide which proposals to be

funded

2009 Important Dates2009 Important Dates

April 22nd Solicitation for pre-proposals

May 20th

Deadline for pre-proposals

July 15th Solicitation for proposals

September 16th

Deadline for proposals

October 23rd

Advisory Committee reviews and recommend projects

November 10th

Policy Board selects projects to be funded

For more information visit WWW.OKEDGE.ORG

or contact us at EDGE@okedge.org