Oklahoma’s innovative action to increase applied research and technology commercialization for more high-paying jobs and a strong, diversified economy
H.E. “Gene” Rainbolt, Chair, Chairman of the Board, BancFirst Corp (Governor Appointee)
Samuel Combs III, President, ONEOK Distribution Co (Pro Tempore Appointee)
Gary W. Derrick, Derrick & Briggs (Governor Appointee)
Ken Levit , Executive Director, George Kaiser Family Foundation (Pro Tempore Appointee)
Thomas C. Kupiec, Ph.D., President and CEO, Analytical Research Laboratories and DNA Solutions (Speaker Appointee)
Greg McKenzie, Attorney, Edmond, Oklahoma (Governor Appointee)
Bond Payne, Chairman of the Board, Heritage Trust (Speaker Appointee)
Paul G. Risser, Ph.D., Executive Director, EDGE Policy Board
EDGE Policy BoardEDGE Policy Board
EDGE legislation clearly defines EDGE legislation clearly defines targeted investment of the EDGE targeted investment of the EDGE fundsfunds(Title 62 O.S. Supp.2007 §47, §52)Requires one or more:
1. Expand directly the number of researchers, technicians and support services and associated activity with in Oklahoma.
2. Have a high potential to result in the formation and growth of advanced technology companies in Oklahoma.
3. Leverage of additional federal research grants and/or privately funded research in Oklahoma
research institutions.
4. Have a high potential to improve the health status and quality of life for Oklahoma
Federal R&D Funding $ RankTotal to Oklahoma $322 M 38Oklahoma per capita $91 45US per capita $364 25
Per capita R&D funding to Oklahoma as % of national average = 25%
If Oklahoma obtained federal R&D funding at the national per capita average, 3 X $322 M = $966,000,000 each yearpumped into the State’s economy
___________________American Association for the Advancement of Science (2007)
EDGE Policy Board
If Oklahoma captured more If Oklahoma captured more federal R&D funding… federal R&D funding…
EDGE Policy Board EDGE Policy Board MissionMissionTo make investments in Oklahoma’s knowledge infrastructure to
bolster the State’s long-term economic growth.
Some key concepts:• increase applied research and technology commercialization • eventually to yield more high-paying jobs
• a stronger, more diversified Oklahoma economy
• business sector priorities
• build capacity, attract external dollars
• relatively large dollar amounts, one to several years
• competitively approved projects. • public and private organizations
• preference for collaboration
EDGE Policy Board EDGE Policy Board OptionsOptions
Awards to “push” and “pull” research and technology
Many types of awards:• proof-of-concept• applied research• matching funds• purchase of equipment• seed capital• other
Many funding instruments:• grants• contracts• no-interest loans• supplementary• funds to existing programs• other approved forms
Operating Policies and ProceduresOperating Policies and Procedures
1. Areas of focus:
Aerospace, Agriculture, Biotechnology, Energy, Information Technology/Telecommunications, Nanotechnology, Sensors, Weather Science, Other
2. Specifications in requests for proposals:
- No minimum-maximum dollar amount
- Funding one year or more
- No indirect costs
- >25% technology commercialization
- <20% for equipment
- Prefer public-private collaboration
- Advisory Board
- Few projects
- Broad publicity
- Return on investment
EDGE Policy Board EDGE Policy Board Advisory CommitteeAdvisory Committee
State and National ExpertsOklahoma 3California 2Florida 1Mississippi 1North Carolina 1Ohio 2
Technical and Business Expertise aerospace, agriculture, biomedical, biotechnology, energy,
genomics, IT and computer science, weather science
High-tech investment at all stages, state research consortium, regional entrepreneurship program, state and federal funding programs
EDGE Advisory CommitteeEDGE Advisory CommitteeJ. Donald CapraJ. Donald Capra, M.D., (Chair), M.D., (Chair)
President Emeritus, Oklahoma Medical Research Foundation, OKPresident Emeritus, Oklahoma Medical Research Foundation, OK
Susan M. Bridges, Susan M. Bridges, Ph.D.Ph.D.
Co-Director, Institute for Digital Biology, Mississippi State UniversityCo-Director, Institute for Digital Biology, Mississippi State University
Leroy ChiaoLeroy Chiao, Ph.D., Ph.D.
Executive Vice President, Excalibur Almaz, Houston, TXExecutive Vice President, Excalibur Almaz, Houston, TX
Richard A. DixonRichard A. Dixon, D. Phil., D. Phil.
DSC, Senior Vice President, Samuel Roberts Noble Foundation, OKDSC, Senior Vice President, Samuel Roberts Noble Foundation, OK
Robert HinesRobert Hines, Ph.D., Ph.D.
President, tech Resources, Inc. Columbus, OHPresident, tech Resources, Inc. Columbus, OH
Robert McNeilRobert McNeil, Ph.D., Ph.D.
Managing Director, Sanderling Venture Partners, San Mateo, CAManaging Director, Sanderling Venture Partners, San Mateo, CA
William PaivaWilliam Paiva, Ph.D., Ph.D.
Manager, Oklahoma Life Science Fund, Sevin Rosen Funds, OKManager, Oklahoma Life Science Fund, Sevin Rosen Funds, OK
Duane RothDuane Roth, Ph.D., Ph.D.
Chief Executive Officer, CONNECT, San Diego, CA Chief Executive Officer, CONNECT, San Diego, CA
Warren QualleyWarren Qualley, Ph.D., Ph.D.
Senior Weather Engineer, Harris Corporation, Washington, DCSenior Weather Engineer, Harris Corporation, Washington, DC
Edward W. UngarEdward W. Ungar, Ph.D., Ph.D.
President, Taratec Corporation, Columbus, OHPresident, Taratec Corporation, Columbus, OH
EDGE Proposal Review EDGE Proposal Review ProcessProcess
StepsSteps
1. Pre-proposals (94)1. Pre-proposals (94)
2. Pre-proposals reviewed by Advisory Committee, Staff and Policy 2. Pre-proposals reviewed by Advisory Committee, Staff and Policy BoardBoard
3.3. Advisory Committee recommended 15 full proposals; Policy BoardAdvisory Committee recommended 15 full proposals; Policy Board
invited 19 proposalsinvited 19 proposals
4. Technical reviewers4. Technical reviewers
5. Advisory Committee selected 7 proposals for presentations;5. Advisory Committee selected 7 proposals for presentations;
recommended 5 projectsrecommended 5 projects
6. Policy Board approved 5 projects, set budget amounts6. Policy Board approved 5 projects, set budget amounts
Lead Organizations on Lead Organizations on ProposalsProposals
Businesses (9)Businesses (9)Charlesson, LLCCharlesson, LLCHyalose, LLCHyalose, LLCJK Autoimmunity, Inc. JK Autoimmunity, Inc. Nantiox, Inc.Nantiox, Inc.Ortho Care Innovations, LLCOrtho Care Innovations, LLCRigen, IncRigen, IncSelexys PharmaceuticalSelexys Pharmaceutical
Corporation Corporation Southwest NanotechnologiesSouthwest NanotechnologiesStrategic SolutionsStrategic Solutions
International, LLCInternational, LLCThe Chickasaw NationThe Chickasaw Nation
Research Organizations (2)Research Organizations (2)Oklahoma Medical Oklahoma Medical Research Foundation Research Foundation Presbyterian Health Presbyterian Health FoundationFoundation
Universities (8)Universities (8)Oklahoma State University Oklahoma State University (4)(4)University of Oklahoma (4)University of Oklahoma (4)
Oklahoma-Glyco-Manufacturing Center: Oklahoma-Glyco-Manufacturing Center: Going Global with Next-Gen Sugar-Based Going Global with Next-Gen Sugar-Based
Therapeutics Therapeutics Principal Investigator: Principal Investigator: Paul DeAngelisPaul DeAngelis
Institution: Hyalose, LLCInstitution: Hyalose, LLC
Business Sector: Business Sector: BiotechnologyBiotechnology
Funding: Funding: $687,609; $550,002$687,609; $550,002
ExplanationExplanation Hyalose--Cytovance Biologics alliance to co-develop the scale-up Hyalose--Cytovance Biologics alliance to co-develop the scale-up
production of sugar-based products; develop FDA-approved procedures production of sugar-based products; develop FDA-approved procedures and documentation. and documentation.
DNA, proteins, lipids and sugars are the major kinds of molecules in the DNA, proteins, lipids and sugars are the major kinds of molecules in the human bodyhuman body
Know that sugar molecules can signal (sugar code) function on other Know that sugar molecules can signal (sugar code) function on other cellscells
Sugars can be constructed in the laboratory to perform specified Sugars can be constructed in the laboratory to perform specified functionsfunctions
Produce glycosaminoglycan (GAG) molecules for evaluation, sale and Produce glycosaminoglycan (GAG) molecules for evaluation, sale and licensinglicensing
Sub-license materials to big pharmaceutical companiesSub-license materials to big pharmaceutical companies Produce low-cost materials for Oklahoma researchersProduce low-cost materials for Oklahoma researchers
Nanoparticle-Mediated Drug Delivery Nanoparticle-Mediated Drug Delivery for the Treatment of Ocular Diseasesfor the Treatment of Ocular Diseases
Principal Investigator: Jian-xing Ma
Institution: Charlesson, LLC
Business Sector: Biotechnology
Funding : $1,382,234; $1,498,797
Explanation Diabetic retinopathy, retinal swelling caused by vascular bleeding, major
complication from diabetes Charlesson has small molecule that significantly reduces retinal vascular
leakage and inflammation Molecule can be encapsulated in a nanoparticle for slow release over >100
days Can also be used to treat age-related macular degeneration Potential for nanoparticle encapsulation technology to be adapted to many
drug therapies Develop a nanoparticle formulation service for other researchers and
applications.
The Renewable EDGEThe Renewable EDGE
Principal Investigator: J. Scott Greene
Institutions: University of Oklahoma and Oklahoma State University
Business Sector: Weather Science
Funding: $996,395; $753,424
Explanation Project will develop geospatial technologies to meet the needs of the
wind and weather science industries and commercialize these products
Develop high-precision wind power assessments and forecast system Develop detailed and accurate estimates of wind density in Oklahoma Develop the geo-spatial tool, ZepherBox, a multi-scale interactive
information system Commercialize these products
Shape Engineering for Advanced Shape Engineering for Advanced Manufacturing (SEAM)Manufacturing (SEAM)
Principal Investigator: Principal Investigator: Skivakumar RamanSkivakumar Raman
Institution: Institution: University of OklahomaUniversity of Oklahoma
Business Sector: Business Sector: AerospaceAerospace
Funding: Funding: $1,500,000; $1,500,000$1,500,000; $1,500,000
ExplanationExplanation Combines university-centered research facility with a for-profit Combines university-centered research facility with a for-profit
corporationcorporation University of Oklahoma, Oklahoma State University, University of University of Oklahoma, Oklahoma State University, University of
TulsaTulsa Shape engineering methodologies through hardware and software Shape engineering methodologies through hardware and software
infrastructuresinfrastructures Product reconfiguration analysis, innovative metrology (precision Product reconfiguration analysis, innovative metrology (precision
measurement), life-cycle analysis, process plans and integrated measurement), life-cycle analysis, process plans and integrated logisticslogistics
Provide a central location for the world’s advanced shape engineering Provide a central location for the world’s advanced shape engineering and manufacturing equipment for assessment and testing servicesand manufacturing equipment for assessment and testing services
U.S. Air Force and commercial aerospace companies;U.S. Air Force and commercial aerospace companies;
Project RESTORED Project RESTORED (Research, Education, Science (Research, Education, Science andand Technology for Orthopedic Rehabilitation and Technology for Orthopedic Rehabilitation and
Economic Development)Economic Development)
Principal Investigator: David Boone
Institution: OrthoCare Innovations, LLC
Business Sector: Biotechnology
Funding: $800,000; $800,000
Explanation Assembles, fabricates and tests prosthetics and orthotics which it
sells to customers who fit patients Expand research, development and manufacturing capacity for
prosthetic devices in Oklahoma Own intellectual property plus license to technology from ORNL,
Hong Kong Polytechnic University; research funding from NIH and DoD
Create a multi-institutional Limb Restoration Institute to foster long-term links with national research institutions and for technology commercialization.
Research, Education, Science and Technology Research, Education, Science and Technology for Orthopedic Rehabilitation and Economic for Orthopedic Rehabilitation and Economic
DevelopmentDevelopmentDavid Boone, Ph.D., OrthoCare Innovations, LLCDavid Boone, Ph.D., OrthoCare Innovations, LLC
Performance Benchmarks
November 1, 2009 Develop 14,000 sq. ft. of manufacturing capacityDevelop 14,000 sq. ft. of manufacturing capacity Bring 3 new advanced prosthetic technologies to marketBring 3 new advanced prosthetic technologies to market Create a prosthetic limb ISO testing laboratoryCreate a prosthetic limb ISO testing laboratory Create a research consortium for research and development, and for Create a research consortium for research and development, and for
technology commercializationtechnology commercialization November 1, 2010 Bring 4 new advanced prosthetic technologies to marketBring 4 new advanced prosthetic technologies to market Host an international symposium on advanced prostheticsHost an international symposium on advanced prosthetics Create 30 new development and technology manufacturing jobsCreate 30 new development and technology manufacturing jobs Establish a non-profit Limb Restoration Institute with a Establish a non-profit Limb Restoration Institute with a
comprehensive program to improve life for amputeescomprehensive program to improve life for amputees
Research, Education, Science and Technology Research, Education, Science and Technology for Orthopedic Rehabilitation for Orthopedic Rehabilitation and Economic Developmentand Economic Development
David Boone, Ph.D., OrthoCare Innovations, LLCDavid Boone, Ph.D., OrthoCare Innovations, LLC
Impact ReportImpact Report 2009 _ ____ 2010 2009 _ ____ 2010
Number of new jobs created Number of new jobs created
Salary distribution of these jobsSalary distribution of these jobs
Number of jobs retained Number of jobs retained Salary distribution of these jobsSalary distribution of these jobs
Other project-based grants/contracts Other project-based grants/contracts Dollars of capital raised Dollars of capital raised Revenue from intellectual property Revenue from intellectual property Patent Applications Patent Applications Patent Awards Patent Awards Revenue from gross sales Revenue from gross sales
2323$32K to $110K$32K to $110K
99$32K to $90K$32K to $90K
2 at $125K each2 at $125K each$1 million$1 million$4 million$4 million
3322
$7 million$7 million
5555$32K to $110K$32K to $110K
3232$32K to $110K$32K to $110K
3 at $150K each3 at $150K each$3 million$3 million$20 million$20 million
4433
$23 million$23 million
EDGE After One YearEDGE After One Year
Year 2008
Widespread interest
Merit-based process
Proposed R&D praised by Advisory Committee
Year 2009
Begin measuring ROI
Responsive to Oklahoma industries
Additional funding instruments
2009 Policy Board Schedule of 2009 Policy Board Schedule of EventsEvents
January 20th EDGE Policy Board meeting to decide annual schedule
April 7th Policy Board meeting to decide parameters of annual
investment program
July 15th Policy Board meeting to decide on formal proposal
solicitations
November 10th Policy Board meeting to decide which proposals to be
funded
2009 Important Dates2009 Important Dates
April 22nd Solicitation for pre-proposals
May 20th
Deadline for pre-proposals
July 15th Solicitation for proposals
September 16th
Deadline for proposals
October 23rd
Advisory Committee reviews and recommend projects
November 10th
Policy Board selects projects to be funded