Date post: | 01-Apr-2015 |
Category: |
Documents |
Upload: | byron-fountain |
View: | 212 times |
Download: | 0 times |
Stefan Braunewell 1
A European project on patient-specific modeling and simulation of FUS in moving organs
Stefan BraunewellFraunhofer MEVIS - Institute for Medical Image Computing, Bremen
Jenny Dankelman, Thomas Langø, Jürgen Jenne, Michael Müller, Yoav Levy, Mario Bezzi, Christine Tanner, Calin Tiu, Daniel Outmazguine, Matthias Günther, Andreas Melzer, Tobias Preusser
Stefan Braunewell 2
• Reflection, refraction, absorption, cavitation
• Heat transfer, tissue reaction
• Cooling by blood flow and perfusion
• Breathing motion
• Occlusion by ribcage
Focused Ultrasound in the LiverFocused Ultrasound
Computer simulation required for reliable outcome prediction
Stefan Braunewell 3
Goal of FUSIMO
Develop, implement and validate a multi-level model for FUS simulation in moving abdominal organsFUSIMO software system aids in: Assessing feasibility Optimizing outcome Detecting risks Monitoring progress, tracking deviations Training
Stefan Braunewell 4
Therapy planning, prediction and monitoring
Functional organ modeling
Model for ultrasound propagation
Motion model for abdominal organs
Patient specific data
Stefan Braunewell 5
Intra-operative ultrasound
On-line
Prediction of Respiratory Motion
Generic 4D respiratory motion model
Off-line
4DMRI toobserve organ
motion
Quantify organ motion
for population
Prediction
On-line
Image of patient
Pre-therapy
Stefan Braunewell 6
Incorporation of motion
Heterogeneous mediaDeactivation of elements
US and temperature simulationRib
Target
XD
[mm]
[mm]
[mm]
[mm]
oC
oC
Stefan Braunewell 7
Parameter identification
Temperature along lesion
Temperature across lesion
MR thermometry of sonication in agar gel
Simulated sonication after recalibration
Stefan Braunewell 8
Functional Modeling
• Cooling effects due to vessels
• Prediction of supply and drainage areas for blood flow
• Prediction and monitoring of tissue damage
Stefan Braunewell 9
Simulation results
Pressure
Temperature Damage Risk
Planning Image
Stefan Braunewell 10
Integrated Software System
• Segmentation• Preview of presumed
motion• Interactive Planning• Exploration of Results• Progress monitoring• Assessment, training
Stefan Braunewell 11
Multi-level validation
• Volunteers• Motion tracking• Motion model• MR imaging protocols
• Phantoms• US, temperature simulation• Steered sonications
Stefan Braunewell 12
System validation
• Validate and optimize workflow• Positioning using Innomotion Robot Arm• Thiel cadavers
- Motion model- Perfusion- Steered sonications
Renal artery perfusion in cadaver
Stefan Braunewell 13
Fraunhofer
MEVIS
University of
DundeeTU Delft
MediriIBSm
mInSightec Ltd
General Electrics
Universita LaSapien
za
ETH Zurich
Fundatia MEDIS
Stefan Braunewell 14
FUSIMO Take Home Message
Integrated software system for FUS in moving organs Assessing feasibility Optimizing outcome Detecting risks Monitoring progress, tracking deviations Training