Subject Index, January-December 1973 || Subject Index

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Proc. Nat. Acad. Sci. USA Vol. 70, pp. 1-49, Subject Index, 1973

Introduction to Subject Index

The Subject Index for Volume 70, January-December 1973 of the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIJINCES is a computer-sorted index. After each index term is printed the title of the article (or a suitable modification of the title) and the appropriate page number. In the issues indexed, the letter "a" was printed after some page numbers; in the index, the "a" has been omitted and a suitable descrip- tive term, e.g., (abstract) has been inserted in the title. Titles are listed in alphabeti- cal order under the index terms.

Classifications (e.g., Physics, Mathematics) under which papers have been published are used as index terms only if it seemed this would be helpful. Papers that are concerned in some major way with methodology are indexed under "Method- ology" as well as under more specific terms. Corrections to papers in which errors occurred are indexed under the term "Corrections" as well as under the index terms selected for the paper itself. Organisms are indexed by their scientific names when scientific names were provided in the papers; suitable cross-references are

provided. Since the PROCEEDINGS urges authors to follow the tentative rules and recommen-

dations of the nomenclature commissions (e.g., for biochemistry, those proposed by the International Union of Pure and Applied Chemistry and the Commission on Biochemical Nomenclature), an effort has been made to construct an index that is as little in conflict with this policy as is possible. However, correction of errors in nomenclature was not attempted and the index should not be looked upon as a reference for correct or recommended usage. In addition, some exceptions to the recommendations of the commissions were necessary. Index terms themselves are not abbreviated even if specific recommendations have been made by the commissions; and in some instances, words within an index term were rearranged. (Thus, tRNA is indexed as "Ribonucleic acid, transfer.") In general, analogues of compounds are indexed as the parent compound. (Thus, N6-butyryladenosine 3':5'-

cyclic monophosphate is indexed as "Adenosine 3':5'-cyclic monophosphate, N6-

butyryl-".) The "recommended trivial name" as listed in Enzyme Nomenclature (1965) Recommendations 1964 of the International Union of Biochemistry (Ameri- can Elsevier Publishing Co., Inc., N.Y., N.Y.) has been used for enzymes whenever Enzyme Commission (EC) numbers were published in the papers since the 1964 recommendations were followed by the editorial staff throughout 1973. EC numbers are listed as part of the entry only if the EC number was printed in the paper. [Thus, some enzymes, have two entries, e.g., "Adenosine triphosphatase" and "Adenosine triphosphatase (EC 3.6.1.3)".]

Because the index terms were sorted (alphabetized) by the computer, many com-

promises had to. be made. Users of the index should bear this in mind and consider obvious alternatives should they not find the term sought.

1



Proceedings of the National Academy of Sciences (USA)

Subject Index to Volume 70

JANUARY-DECEMBER 1973

Absorbance change, light-induced Light-induced absorbance changes associated with phototaxis in

Dictyostelium, 813 Accelerator

CERN intersecting storage rings (ISR) (N.A.S. Symposium: new accelerators), 619

Clinton P. Anderson Meson Physics Facility (LAMPF) (N.A.S. Symposium: new accelerators), 603

Colliding beams versus beams on stationary targets: competing tools (N.A.S. Symposium: new accelerators), 611

Acetate Juvenile hormones, biosynthesis in Manduca sexta: labeling

pattern from mevalonate, propionate, and acetate, 2921 Acetoxycycloheximide

Cycloheximide and acetoxycycloheximide: inhibition of tyrosine hydroxylase activity and amnestic effects, 354

Acetoxymercuration Synthesis and enzymatic polymerization of nucleotides containing

mercury: potential tools for nucleic acid sequencing, 2238 Acetylation

Acetylation of sickle cell hemoglobin by aspirin, 1313 Acetylcholine

see also Receptor for acetylcholine Acetylcholine biosynthesis in turtle photoreceptors (correction),

284 Acetylcholine-like molecular arrangement in psychomimetic

anticholinergic drugs, 3103 Acetylcholine receptor clusters on cultured muscle cells, 270 Affinity-labeling of partially purified acetylcholine receptor from

electric tissue of Electrophorus, 3636 Guanosine 3':5'-cyclic monophosphate and action of insulin and

acetylcholine, 2443 Intrasomatic injection of radioactive precursors for studying

transmitter synthesis in identified neurons of Aplysia californica, 3371

Purified eel acetylcholine receptor and anti-acetylcholine receptor antibody, 3334

Acetylcholinesterase (EC 3.1.1.7) Acetylcholine receptors, regulation in relation to

acetylcholinesterase in neuroblastoma cells, 2902 Acetylcholine receptors, regulation in relation to

acetylcholinesterase in neuroblastoma cells (correction), 3932 Acetylcholinesterase from electric organ tissue of electric eel:

molecular structures, 2473 Photoaffinity labeling, mechanism of, 2567 Segregation during ascidian embryogenesis of egg cytoplasmic

information for tissue-specific enzyme development, 2096 Synaptic rearrangement in dentate gyrus: histochemical evidence

of adjustments after lesions in immature and adult rats, 3473 Acetylene

Reduction of acetylene and hydrazine with molybdenum-glutathione complex, 339

N-Acetylgalactosaminyltransferase Chondrogenic expression, control of in mesodermal cells of

embryonic chick limb, 1713 N-Acetyl-D-galactosaminyltransferases produced by human Al

and A2 genes, qualitative differences, 220 --N-Acetylglucosaminidase (EC 3.2.1.30) Mutations affecting N-acetylglucosaminidase in Dictyostelium

discoideum, 3356 Acetylsalicylic acid

Acetylation of sickle cell hemoglobin by aspirin, 1313 Aspirin, effect on sickling and oxygen affinity of erythrocytes,

3707 Acheta

Amplified ribosomal DNA release from chromomeres of Acheta, 80

Acholeplasma laidlauii Phospholipid vesicles, fusion of, with viable Acholeplasma

laidlawii, 1238 Actin

Actin, complete amino acid sequence in rabbit skeletal muscle, 2687

Actin in dividing cells: contractile ring filaments bind heavy meromyosin, 1688

Muscular contraction, theory extended to groups of actin sites, 2732

Actinomycete Aminoglycoside antibiotic-inactivating enzymes in actinomycetes

that are similar to those present in clinical isolates of antibiotic-resistant bacteria, 2276

Actinomycin D Pineal protein kinase: effect of enzymic phosphorylation on

actinomycin D binding by, and template activity of, chromatin, 755

Translational control of specific uterine protein synthesis after estrogen induction, 18

Active transport Active transport model of sodium and potassium ions as mediated

by tetrameric enzyme, 275 Adenosine 3':5'-cyclic monophosphate, role in early transport

changes induced by serum and insulin in quiescent fibroblasts, 3609

Anaerobic transport in Escherichia coli membrane vesicles, 3376 Dansyl-galactoside: fluorescent probe of active transport in

bacterial membrane vesicles, 2722 Different mechanisms of energy coupling for active transport of

proline and glutamine in Escherichia coli, 1514 Electrical potential, role in coupling of metabolic energy to active

transport by membrane vesicles of Escherichia coli, 1804 Galactoside, proton-coupled accumulation in Streptococcus

lactis 7962, 2866 Illicit transport: oligopeptide permease, 456

Acyl-coenzyme A Complex formation between mycobacterial polysaccharides and

fatty acyl-CoA derivatives, 1146 Acyl glyceraldehyde 3-phosphate dehydrogenase

Covalent enzyme-substrate bond activation by noncovalent interaction with an effector, 2077

Adaptation in animals Genic variability and strategies of adaptation in animals, 1875

Adaptive radiation Ecological theory for sudden origin of multicellular life in late

Precambrian, 1486 Addendum

see also Corrections Membrane sealing in frog skeletal-muscle fibers (addendum),

3007 Addiction

Methadone plasma level: sustained by reservoir of drug in tissue, 10

e-Adenine Flavin 1,N6-ethenoadenine dinucleotide: dynamic and static

quenching of fluorescence, 941 Adenine phosphoribosyltransferase (EC 2.4.2.7)

Hypoxanthine phosphoribosyltransferase, reexpression of rat gene in rat-human hybrids, 2590

Adenosine 3':5'-cyclic monophosphate Adenosine 3':5'-cyclic monophosphate as regulator of bacterial

transformation, 471 Adenosine 3':5'-cyclic monophosphate-dependent protein kinase,

studies on orientation in human erythrocyte membranes, 3735 Adenosine 3':5'-cyclic monophosphate in Chlamydomonas

reinhardtii: isolation and characterization, 1099 Adenosine 3':5'-cyclic monophosphate receptor, specific

photoaffinity labeling in intact ghosts from human erythrocytes, 3344

Adenosine 3':5'-cyclic monophosphate, role in early transport changes induced by serum and insulin in quiescent fibroblasts, 3609

Adenosine-mediated elevation of cyclic 3':5'-adenosine monophosphate concentrations in cultured mouse neuroblastoma cells, 3099

Adenosine 3':5'-monophosphate activates membrane-bound phosphoprotein phosphatase from toad bladder, 1831

5'-Adenosine monophosphate-dependent adenylate cyclase and adenosine 3':5'-cyclic monophosphate-dependent adenosine triphosphate pyrophosphohydrolase in Dictyostelium discoideum, 1254

Bradykinin and indomethacin, effects on cyclic GMP and cyclic AMP in lung slices, 3830

Cultured iris epithelial cells, induction of stellate configuration by adenosine and compounds related to adenosine 3':5'-cyclic monophosphate, 2286

Cyclic adenosine monophosphate receptor: loss of cAMP-dependent DNA binding activity after proteolysis in presence of cyclic adenosine monophosphate, 2529

Cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and isolation of resistant variants, 76

Dictyostelium plasma membranes, response to adenosine 3':5'-cyclic monophosphate, 1630

Guanosine 3':5'-cyclic monophosphate and action of insulin and

2



Proc. Nat. Acad. Sci. USA 70 (1973)

acetylcholine, 2443 Interrelationship between adenylate cyclase activity, adenosine

3':5'-cyclic monophosphate phosphodiesterase activity, adenosine 3':5'-cyclic monophosphate levels, and growth of cells in culture, 3802

Measurements of rates of adenosine 3':5'-cyclic monophosphate synthesis in intact Escherichia coli B, 2149

Mutant of 3T3 cells with cyclic AMP metabolism sensitive to temperature change, 2906

Mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate, 1017

Nerve growth factor and cyclic AMP, mechanism of action on neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation, 2448

Nucleoside cyclic 3':5'-monophosphate phosphodiesterase activity from rat brain, regulation by modulator and Ca2+, 3526

Phosphorylation of specific protein regulation in toad-bladder membrane by antidiuretic hormone and cyclic AMP, and its possible relationship to membrane permeability changes, 880

Phosphorylation of specific protein regulation in toad-bladder membrane by antidiuretic hormone and cyclic AMP, and its possible relationship to membrane permeability changes (correction), 1903

Photoreceptors, regulation of cyclic nucleotide concentrations: ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light, 3820

Pleiotypic control by cyclic AMP: interaction with cyclic GMP and possible role of microtubules, 1659

Transformation of chick-embryo fibroblasts by wild-type and temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity, 1055

Adenosine 3':5'-cyclic monophosphate, 8-bromo- 8-Bromoadenosine 3':5'-cyclic monophosphate as promoter of cell

division in excised tobacco pith parenchyma tissue, 447 Adenosine 3':5'-cyclic monophosphate, monobutyryl-


Phosphorylation of specific protein regulation in toad-bladder membrane by antidiuretic hormone and cyclic AMP, and its possible relationship to membrane permeability changes (correction), .1903

Adenosine 3':5'-cyclic monophosphate, N6-butyryl- Insulin effect on growth pattern and adenylate cyclase activity of

BHK fibroblasts, 1388 Adenosine 3':5'-cyclic monophosphate, N^,02'-dibutyryl-

Pleiotypic control by adenosine 3':5'-cyclic monophosphate: model for growth control in animal cells, 1432

Adenosine 3':5'-cyclic monophosphate phosphodiesterase Interrelationship between adenylate cyclase activity, adenosine

3':5'-cyclic monophosphate phosphodiesterase activity, adenosine 3':5'-cyclic monophosphate levels, and growth of cells in culture, 3802

Adenosine 3':5'-cyclic monophosphate receptor protein see Catabolite activator protein

Adenosine diphosphate Mitochondrial adenosine diphosphate uptake, stimulation by

thyroid hormones, 98 5'-Adenosine monophosphate

5'-Adenosine monophosphate-dependent adenylate cyclase and adenosine 3':5'-cyclic monophosphate-dependent adenosine triphosphate pyrophosphohydrolase in Dictyostelium discoideum, 1254

Adenosine monophosphate 1,N6-etheno- 1,N6-Ethenoadenosine triphosphate and 1,N6-ethenoadenosine

monophosphate, role in firefly luminescence, 1664 Adenosine triphosphatase

Adenosine triphosphatase and guanosine triphosphatase activities associated with specific 5S RNA-protein complex, 2870

Mitochondrial membrane system assembly: purification of mitochondrial product of ATPase, 3155

Myocardial myosin, regulatory properties, 3205 Adenosine triphosphatase (EC 3.6.1.3)

Active transport model of sodium and potassium ions as mediated by tetrameric enzyme, 275

Adenosine triphosphate Deoxyribonucleic acid polymerase III star requires ATP to start

synthesis on primed DNA, 3679 Electron transport-linked compared with proton-induced ATP

generation in Thiobacillus novellus, 3571 Membrane changes and adenosine triphosphate content in normal

and malignant transformed cells, 1780 Myosin adenosine triphosphate hydrolysis: mechanism involving

magnesium chelate complex, 3793 Photoreceptors, regulation of cyclic nucleotide concentrations:

ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light, 3820

Adenosine triphosphate-dependent deoxyribonuclease Deoxyribonucleic acid, isolation of circular molecules from whole

cellular DNA by use of ATP-dependent deoxyribonuclease, 2884 Adenosine triphosphate: guanosine monophosphate

phosphotransferase see Guanvlate kinase

Adenosine triphosphate 1,N"-etheno- 1,N6-Ethenoadenosine triphosphate and 1,N6-ethenoadenosine

monophosphate, role in firefly luminescence, 1664 Adenosine triphosphate pyrophosphohydrolase

5'-Adenosine monophosphate-dependent adenylate cyclase and adenosine 3':5'-cyclic monophosphate-dependent adenosine

Subject Index 3

triphosphate pyrophosphohydrolase in Dictyostelium discoideum, 1254

Adenovirus-associated virus deoxyribonucleic acid Self-complementarity of terminal sequences within plus or minus

strands of adenovirus-associated virus DNA, 215 Adenovirus type 2

Adenovirus type 2 DNA cleavage into six unique fragments by endonuclease R*RI, 200

Adenylate cyclase 5'-Adenosine monophosphate-dependent adenylate cyclase and

adenosine 3':5'-cyclic monophosphate-dependent adenosine triphosphate pyrophosphohydrolase in Dictyostelium discoideum, 1254

Adrenal tumor cells, stimulation of steroid secretion by choleragen, 2741

Insulin effect on growth pattern and adenylate cyclase activity of BHK fibroblasts, 1388

Insulin-like activity of concanavalin A and wheat germ agglutinin: direct interactions with insulin receptors, 485

Interrelationship between adenylate cyclase activity, adenosine 3': 5'-cyclic monophosphate phosphodiesterase activity, adenosine 3':5'-cyclic monophosphate levels, and growth of cells in culture, 3802

Measurements of rates of adenosine 3':5'-cyclic monophosphate synthesis in intact Escherichia coli B, 2149

Temperature-sensitive change in energy of activation of hormone-stimulated hepatic adenylyl cyclase, 1785


Adenylylation Cytoplasmic adenylylation and processing of maternal RNA, 406 Post-transcriptional adenylation of herpes virus RNA,

relationship with messenger RNA abundance, 2101 Adjuvanticity

Structure of bacterial lipopolysaccharides, relationship to its function in mitogenesis and adjuvanticity, 2129

Adrenal medulla Tyrosine hydroxylase protein, immunochemical demonstration of

increased accumulation in sympathetic ganglia and adrenal medulla elicited by reserpine, 2767

Adrenal tumor cell Adrenal tumor cells, stimulation of steroid secretion by

choleragen, 2741 Adrenergic agent

Guanosine 3':5'-cyclic monophosphate, new enzymatic assay and its application to ductus deferens of rat, 1721

Adrenergic receptor Catecholamine transmitter regulates supersensitivity and

subsensitivity of ,-adrenergic receptor in pineal gland, 2411 Adrenocorticotropic hormone


Aerobacter aerogenes Nucleotide sequence divergence in a-chain-structural genes of

tryptophan synthetase from Escherichia coli, Salmonella typhimurium, and Aerobacter aerogenes, 1112

Affinity binding Affinity binding of intact fat cells and their ghosts to immobilized

insulin, 792 Affinity-labeling

Affinity-labeling of partially purified acetylcholine receptor from electric tissue of Electrophorus, 3636

3-Bromo-2-butanone 1,4-bisphosphate as affinity label for ribulosebisphosphate carboxylase, 3721

Chloramphenicol-binding protein, identification in Escherichia coli ribosomes by affinity labeling, 2229

African children Malignant lymphomas of African children, 15

Agglutinin see Wheat germ agglutinin

Aging Deficient DNA repair in human progeroid cells, 977 Erythrocytes, normal production by mouse marrow for 73

months, 3184 Inactive enzyme molecules in aging mice: liver aldolase, 909

Alanine aminotransferase (EC 2.6.1.2) Differentiated functions in hepatoma cell hybrids: expression of

alanine aminotransferase, 377 Protective effect of ascorbic acid on hepatotoxicity caused by

sodium nitrite plus aminopyrine, 747 D-Alanine carboxypeptidase

Detergent hydrophobic lipophilic balance (HLB) number, relation to solubilization and stabilization of D-alanine carboxypeptidase from Bacillus subtilis membranes, 2997

Albumin, bovine-serum Polarographic catalytic waves observed with bovine-serum

albumin: kinetic or diffusion control, 2020 Polarographic catalytic waves observed with bovine-serum

albumin: kinetic or diffusion control (correction), 2710 Alcohol

see also Ethyl alcohol Nuclear magnetic resonance shift reagents: evidence for different

mechanisms of contact contributions to carbon-13 shifts induced by nickel and cobalt acetylacetonates with saturated amines and alcohols, 939

Alcohol dehydrogenase (EC 1.1.1.1) Alcohol dehydrogenase of liver: structure at 2.9 angstrom

resolution, 2439



4 Subject Index Proc. Nat. Acad. Sci. USA 70 (1973)

Alcohol dehydrogenase of yeast and liver: partial similarities, 2295

Aldehyde, unsaturated Amines, interaction with ketone aldehydes and unsaturated

aldehydes, 1030 Algae

see Nostoc muscorum; Volvox; Chlamydomonas Algebra

p-Algebras of arbitrary exponents, 533 Alkaline phosphatase (EC 3.1.3.1)

Alkaline phosphatase activity in mouse teratoma, 3899 Placental alkaline phosphatase, structural comparison of ectopic

and normal, 2936 Alkaline sucrose gradient

Deoxyribonucleic acid of mammalian cells, molecular nature in alkaline sucrose gradients, 3660

Alkanes Nonheuristic computer determination of molecular structure

based upon carbon-13 nuclear magnetic resonance data: branched alkanes, 3419

n-Alkyl carboxylic acid Hydrophobicity of long chain n-alkyl carboxylic acids as

measured by their distribution between heptane and aqueous solutions, 289

Allantoin degradative enzyme Allantoin degradative enzymes, induction in Saccharomyces

cerevisiae by last intermediate of pathway, 2340 Allelic frequency

Adaptive linkage disequilibrium between two esterase loci of salamander, 1156

Allograft tolerance Allograft tolerance: presumptive evidence that serum factors

from tolerant animals that block lymphocyte-mediated immunity in vitro are soluble antigen-antibody complexes, 2539

Allophycocyanin Allophycocyanin as light-harvesting pigment in cyanobacteria,

3130 Allosteric enzyme

Spatiotemporal organization, patterns in allosteric enzyme model, 3255

Allotypic marker Human anti-IgM iso-antibodies: detection of IgM allotypic

markers, 827 Allozymic variation

Self-fertilization and genetic population structure in colonizing land snail, 1186

Alveolar proteinosis Glycoproteins from patients with alveolar proteinosis, 973

Amine Amines, interaction with ketone aldehydes and unsaturated

aldehydes, 1030 Charge transfer between amine and carbonyl, 3139 Nuclear magnetic resonance shift reagents: evidence for different


Amine, saturated Nuclear magnetic resonance shift reagents: abnormal carbon-13

shifts produced by complexation of lanthanide chelates with saturated amines and n-butyl isocyanide, 562

Amino acid composition Globular protein, prediction of amount of secondary structure

from amino acid composition, 2809 Amino acid, nearest-neighbor

Nearest-neighbor amino acids, influence on conformation of middle amino acid in proteins: comparison of predicted and experimental determination of (-sheets in concanavalin A, 1473

Amino acid sequence Actin, complete amino acid sequence in rabbit skeletal muscle,

2687 Amino acid sequence of dogfish M4 lactate dehydrogenase, 1790 Amino acid sequence of dogfish M4 lactate dehydrogenase

(correction), 2467 Amino-acid sequence of flagellin from Bacillus subtilis 168:

comparison with other bacterial flagellins, 3428 Amino-acid sequence of lac repressor, 3576 Amino acid sequence of porcine pepsin, 3437 Mouse lambda-chain sequences, 2112 Protein Hal: partial deletion of "-y" immunoglobulin gene(s) and

apparent reinitiation at internal AUG codon, 1073 Amino acid transport

Amino acid, evidence of inter-organ transport by blood cells in humans, 1775

y-Glutamyl cycle, enzymes in ciliary body and lens, 2211 y-Glutamyl cycle in choroid plexus: its possible function in amino

acid transport, 1447 Amino acid utilization

Atypical pattern of utilization of amino acids for mitochondrial protein synthesis in HeLa cells, 1490

Aminoacylation Amino-acid acceptor activity of "70S-associated" 4S RNA from

avian myeloblastosis virus, 1184 Conformation of charged and uncharged tRNAPhe, 2193 Synthesis and aminoacylation of 3'-amino-3'-deoxy transfer RNA

and its activity in ribosomal protein synthesis, 2671 Aminoacyl-transfer ribonucleic acid synthetase

Stopped-flow apparatus with light-scattering detection and its application to biochemical reactions, 890

w-Aminoalkyl-agarose Hydrophobic chromatography: use for purification of glycogen

synthetase, 778 Aminoglycoside antibiotic

Aminoglycoside antibiotic-inactivating enzymes in actinomycetes that are similar to those present in clinical isolates of antibiotic-resistant bacteria, 2276

b-Aminolevulinic acid Coupling between bacteriochlorophyll and membrane protein

synthesis in Rhodopseudomonas spheroids, 799 Aminopeptidase (EC 3.4.11.1)

Thermophilic aminopeptidase I, function of two subunits, 3781 Aminopyrine

Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine, 747

Amnesia Cycloheximide and acetoxycycloheximide: inhibition of tyrosine

hydroxylase activity and amnestic effects, 354 Amphibian larva

see also Embryo, amphibian Specificity of antibodies in amphibian larvae possessing small

number of lymphocytes, 1898 Anemia

see Sickle-cell anemia; Thalassemia Anesthesia

Pressure effect on membrane action of nerve-blocking spin label, 3179

Animal cells grown in culture Manipulation of fatty acid composition in animal cells grown in

culture, 3669 Antamanide complexes

Conformation Li-antamanide complex and Na-[Phe4, Val6]antamanide complex, in crystalline state, 1836

Antheraea polyphemus Moth follicular cells, purification of family of specific messenger

ribonucleic acids, 3764 Anthranilate synthetase

Anthranilate synthetase synthesis, regulation in vitro by N-gene protein of phage lambda, 1078

Nucleotide sequences from tryptophan messenger RNA of Escherichia coli: sequence corresponding to amino-terminal region of first polypeptide specified by operon, 2335

Anthropology Racemization reaction of aspartic acid and its use in dating fossil

bones, 1331 Antibiotic

see also specific antibiotics Aminoglycoside antibiotic-inactivating enzymes in actinomycetes


Antibiotic resistance gene Recircularization and autonomous replication of sheared R-factor

DNA segment in Escherichia coli transformants, 1293 Antibiotic X-537A

Glutamate and isocitrate, inhibition of oxidation in liver mitochondria at specific NADP+-reducing site, 3450

Antibody, cytosine-specific Chromosome structure as revealed by combined chemical and

immunochemical procedure, 804 Antibody, cytotoxic

New complement-mediated cytolytic mechanism: Cl-bypass activation pathway, 649

Antibody, iso- Human anti-IgM iso-antibodies: detection of IgM allotypic

markers, 827 Antibody to acetylcholine receptor


Antibody to avian myeloblastosis virus Avian oncornavirus proteins, identification of large polypeptide

precursor, 1734 Antibody to dextran

Immunochemical analysis of cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody, 235

Antibody to hapten Antibodies with multiple binding functions: induction of single

immunoglobin species by structurally dissimilar haptens, 3269 Antibody to nitrophenyl conjugates

Specificity of antibodies in amphibian larvae possessing small number of lymphocytes, 1898

Antibody, univalent Membrane sites in aggregating Dictyostelium cells, quantitation

by use of tritiated univalent antibody, 3150 Anticodon loop

Y base, effect of removal on conformation of yeast tRNAPhe, 3843

Anti-dextran activity Immunochemical analysis of cross-reacting idiotypes of mouse

myeloma proteins with anti-dextran activity and normal anti-dextran antibody, 235

Antidiuretic hormone Adenosine 3':5'-monophosphate activates membrane-bound

phosphoprotein phosphatase from toad bladder, 1831 Phosphorylation of specific protein regulation in toad-bladder

membrane by antidiuretic hormone and cyclic AMP, and its possible relationship to membrane permeability changes, 880

Phosphorylation of specific protein regulation in toad-bladder membrane by antidiuretic hormone and cyclic AMP, and its




possible relationship to membrane permeability changes (correction), 1903

Antigen see also Tumor-specific antigen; Tumor-associated antigen Immunoferritin localization of intracellular antigens: use of

ultracryotomy to obtain ultrathin sections suitable for direct immunoferritin staining, 1649

Antigen, allo- Locus determining lymphocyte cell-surface alloantigen in mice:

Ly-4, 1108 Antigen-antibody complex

Allograft tolerance: presumptive evidence that serum factors from tolerant animals that block lymphocyte-mediated immunity in vitro are soluble antigen-antibody complexes, 2539

Antigen, cell-sprface Cell-surface antigen associated with murine sarcoma virus by

immunoelectronmicrpscopy, 742 Common cell-surface antigen associated with murine and feline

C-type RNA leukemia viruses, 1878 Interferon enhances expression of surface antigens on murine

leukemia L 1210 cells, 2785 Surface antigens common to mouse cleavage embryos and

primitive teratocarcinoma cells in culture, 2988 Surface antigens common to mouse cleavage embryos and

primitive teratocarcinoma cells in culture (correction), 3932 Antigen, crossreactive

Crossreactive antigens on human cells infected with Rauscher leukemia virus and on human acute leukemia cells, 495

Antigen-derivatized fiber Immunological function of lymphocytes fractionated with

antigen-derivatized fibers, 3894 Antigen, F

Purification of Hodgkin's disease tumor-associated antigens, 396 Antigen, HL-A

Human f2-microglobulin, multiple common properties and common portion fragment derived from HL-A antigen molecules, 2863

Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments, 1603

Antigen, H-Y Topographical location of H-Y antigen on mouse spermatozoa by

immunoelectronmicroscopy, 1502 Antigen, lymph-node

New lymphocyte antigen system (Lna) controlled by Ir region of mouse H-2 complex, 2509.

Antigen, neo- Discriminating neoantigenic differences between fibrinogen and

fibrin derivatives, 1169 Antigen, nonvirion

Nonvirion antigens produced by herpes simplex viruses 1 and 2, 1032

Antigen, S Purification of Hodgkin's disease tumor-associated antigens, 396

Antigen, viral envelope Cell-surface antigen associated with murine sarcoma virus by

immunoelectronmicroscopy, 742 Antihemophilic factor

Factor VIII recombination after dissociation by CaC12, 2326 Plasma aggregating factor (bovine) for human platelets: marker

for study of antihemophilic and von Willebrand factors, 2814 Antimony

High-pressure spectral studies of mixed valence compounds of antimony, 3065

Antioxidant Carcinogen-induced chromosomal breakage decreased by

antioxidants, 1461 Antiviral agent

1-1-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole): new broad-spectrum antiviral agent, 1174

Antiviral chemotherapy 5-Bromodeoxycytidine, phosphorylation in cells infected with

herpes simplex virus, 3788 Antiviral effect

Antiviral effect of interferon covalently bound to Sepharose, 2360 Aorta-contracting substance

Endoperoxide intermediate in prostaglandin biosynthesis: detection and isolation, 899

Aplysia californica Intrasomatic injection of radioactive precursors for studying


Apolipoprotein-alanine Peptide fragments of apolipoprotein-alanine: chemical synthesis

and biochemical properties, 2124 Apoprotein

Primary dysbetalipoproteinemia: predominance of specific apoprotein species in triglyceride-rich lipoproteins, 2015

Applied biology Temperature-sensitive lethality in Nicotiana tabacum L., 108

Applied mathematics Magnetofluid-dynamic spectrum and low shear stability, 3277 Population growth, generalized Verhulst laws, 3048 Predator-prey patterns, 2069

Applied physical science Downwind and upwind effects in Arizona cloud-seeding

experiment, 357 Rubbery materials, new elastic potential function, 3041

Arabidopsis thaliana Transgenosis of genes from bacteria to plant cells: biological and

Subject Index 5

molecular evidence, 723 Arachidonic acid


Arbacia punctulata Maternal histone messenger RNA: detection by molecular

hybridization, 2840 Arsantilazotyrosine-248 carboxypeptidase A

Conformations of arsanilazotyrosine-248 carboxypeptidase A: comparison of crystals and solution, 2006

Arthritis see Rheumatoid arthritis

Ascites cell, Ehrlich Wet chemical method for rendering scanning electron microscopy

samples conductive and observations on surface morphology of human erythrocytes and Ehrlich ascites cells, 3599

Ascites cell, Krebs II Cell-free synthesis of rat growth hormone, 3646 Double-stranded RNA as inhibitor of protein synthesis and as

substrate for nuclease in extracts of Krebs II ascites cells, 225 Hemin effect on synthesis of hemoglobin and other proteins in

mammalian cells, 1022. Ascites cell line, mouse

Mouse mammary tumor virus, production in vitro in mouse mammary tumor ascites line, 2983

Ascites cell, mouse leukemia Ca2+ transport by mitochondria from L1210 mouse ascites tumor

cells, 1744 Ascites cell, Novikoff

Eukaryotic DNA-dependent RNA polymerase stimulation by protein factors, 1383

Ascites cell, Novikoff hepatoma Nucleolar proteins o'f normal rat liver, comparison with Novikoff

hepatoma ascites cells by two-dimensional polyacrylamide gel electrophoresis, 1316

Ascorbic acid see Vitamin C

Aspartate carbamoyltransferase (EC 2.1.3.2) Aspartate transcarbamoylase from FJscherichia coli: electron

density at 5.5 angstrom resolution, 1117 Aspartic acid

Racemization reactiqn of aspartic acid and its use in dating fossil bones, 1331

Aspirin see Acetylsalicylic acid

Asymptotics Asymptotics of some relativistic Markov processes, 3551

Atherosclerosis Monoclonal origin of human atherosclerotic plaques, evidence for,

1753 Atmosphere

see Earth's atmosphere Atomic orbital

Computation of large molecules with Hartree-Fock model (correction), 284'

ATPase see Adenosine triphosphatase

Auditory feedback Continuous noise, effects on avian hearing and vocal

development, 1393 Auditory neuronal response

Auditory neuronal responses, development in avian embryos, 1795

Aurintricarboxylic acid Factor-promoted dissociation of free ribosomes in rabbit

reticulocyte lysate system: inhibition and requirement for energy source, 787

Author index Author index to volume 70 of Proc. Nat. Acad. Sci. USA, 3937

Autoimmunity Chromosomal abnormalities in spleens of New Zealand Black

mice: strain characterized by autoimmunity and malignancy, 1094

Automimicry Automimicry, theoretical investigations: multiple trial learning

and palatability spectrum, 2261 Autoradiography

Iodine-125-labeled DNA-RNA hybrids in cytological preparations, 1536

Autoregulation Autoregulation: role for biosynthetic enzyme in control of gene

expression, 2757 Auxin

Auxin-induced hydrogen ion excretion from Avena coleoptiles, 3092

8-Bromoadenosine 3':5'-cyclic monophosphate as promoter of cell division in excised tobacco pith parenchyma tissue, 447

Avena sativa Auxin-induced hydrogen ion excretion from Avena coleoptiles,

3092 Avian leukosis virus

Marek's disease herpesvirus and avian leukosis virus, biological and biochemical evidence for interaction in vivo, 3175

Avian myeloblastosis virus Amino-acid acceptor activity of "70S-associated" 4S RNA from

avian myeloblastosis virus, 1184 Avian myeloblastosis virus, single subunit with both

RNA-directed DNA polymerase and ribonuclease H activity, 230




Avian myeloblastosis virus, single subunit with both RNA-directed DNA polymerase and ribonuclease H activity (correction), 1284

Avian oncornavirus proteins, identification of large polypeptide precursor, 1734

Methionine transfer ribonucleic acids of avian myeloblastosis virus, 2823

Minor base composition of "70S-associated" 4S RNA from avian myeloblastosis virus, 865

Primer requirement and template specificity of DNA polymerase of chick embryo, 1229

Ribonuclease H isolated from avian myeloblastosis virus and Escherichia coli, mechanism of action, 466

Avian sarcoma virus see Mutant of avian sarcoma virus

Axon see Neuron; Nerve

Axonal transport Differential transport of protein in axons: comparison between

sciatic nerve and dorsal columns of cats, 1521 Azide coupling

Biological activities of synthetic peptides corresponding to fragments of and to entire sequence of vasoactive intestinal peptide, 382

Azotobacter vinelandii Electron paramagnetic resonance of nitrogenase and nitrogenase

components from Clostridium pasteurianum W5 and Azotobacter vinelandii OP (correction), 627

Bacillus amyloliquefaciens Ribonucleic acid polymerase from Bacillus amyloliquefaciens

infected with k29 bacteriophage, 2234 Bacillus stearothermophilus

Functional correspondence between 30S ribosomal proteins of Escherichia coli and Bacillus stearothermophilus, 944

Bacillus subtilis Amino-acid sequence of flagellin from Bacillus subtilis 168:

comparison with other bacterial flagellins, 3428 Deoxyribonucleic acid polymerase from Bacillus subtilis,

inhibition by hydroxyphenylazopyrimidines, 103 Detergent hydrophobic lipophilic balance (HLB) number, relation

to solubilization and stabilization of D-alanine carboxypeptidase from Bacillus subtilis membranes, 2997

Hydroxyphenylazopyrimidines: characterization of active forms and their inhibitory action on DNA polymerase from Bacillus subtilis, 512

Isolation of new RNA polymerase-binding protein from sporulating Bacillus subtilis, 490

Ribonucleic acid polymerase mutation causing temperature-sensitive sporulation in Bacillus subtilis, 1179

Sigma activity of RNA polymerase of Bacillus subtilis, loss during sporulation, 1865

Bacteria see also Cyanobacteria; Lipopolysaccharide, bacterial; Protein

synthesis in bacteria; Membrane, bacterial; Ribonucleic acid-dependent deoxyribonucleic acid polymerase, bacterial; Ribosome, Escherichia coli; Transformation of bacteria; specific bacteria

Transgenosis of genes from bacteria to plant cells: biological and molecular evidence, 723

Bacteria, antibiotic-resistant Aminoglycoside antibiotic-inactivating enzymes in actinomycetes


Bacterial test system Improved bacterial test system for detection and classification of

mutagens and carcinogens, 782 Improved bacterial test system for detection and classification of

mutagens and carcinogens (correction), 1903 Bacteriochlorophyll

Coupling between bacteriochlorophyll and membrane protein synthesis in Rhodopseudomonas spheroids, 799

Bacteriophage A Alignment of two DNA helices: model for recognition of DNA base

sequences by termini-generating enzymes of phage X, 186, and P2, 2667

Anthranilate synthetase synthesis, regulation in vitro by N-gene protein of phage lambda, 1078

Bacteriophage X deoxyribonucleic acid, effect of circularity and superhelicity on transcription, 3077

Bacteriophage. lambda heads, assembly in vitro, 260 Multiple repressor binding at operators in bacteriophage X, 1531 --Protein specified by bacteriophage X, purification and

properties: inhibitor of host, RecBC recombination enzyme, 2215 Regulation of expression of N gene of bacteriophage lambda, 421 Ribonucleic acid polymerase of Escherichia coli, regulation of

subunit synthesis, 2651 3'-Terminal nucleotide sequences of bacteriophage A DNA, 1151

Bacteriophage b29 Ribonucleic acid polymerase from Bacillus amyloliquefaciens

infected with 029 bacteriophage, 2234 Bacteriophage 080

Adjacent transfer RNA genes in Escherichia coli, 438 Histidine operon, inhibition of transcription in vitro by first

enzyme of histidine pathway, 2692 Bacteriophage bX174

Bacteriophage lX-174, replication in mutant of Escherichia coli defective in dnaE gene, 1757

Deoxyribonucleic acid methylase induced by bacteriophage qX174, 3773

Deoxyribonucleic acid synthesis in vitro: purification of dTaG gene product from Escherichia coli, 1613

Deoxyribonucleic acid synthesis in vitro: purification of dnaC gene product containing dnaD activity from Escherichia coli, 2369

Bacteriophage fl Colicins E3 and K resistance, induced by infection with

bacteriophage fl, 3160 Deoxyribonucleic acid polymerase I primed by synthetic

oligonucleotide used to determine nucleotide sequence in phage fl DNA, 1209

Ribonuclease H of calf thymus: purification and properties, 1959 Bacteriophage f2

Protein chain termination: further characterization of mutant defective in new protein synthesis factor, 31

Bacteriophage M13 Coat protein of bacteriophage M13 virion participates in

membrane-oriented synthesis of DNA, 205 Bacteriophage MS2

Membrane binding of replicative RNA of bacteriophage MS2, two classes, 2381

Bacteriophage Mu Genetic mapping of inversion loop in bacteriophage Mu DNA,

2153 Bacteriophage P2

Alignment of two DNA helices: model for recognition of DNA base sequences by termini-generating enzymes of phage X, 186, and P2, 2667

Bacteriophage P22 Genetic method for determining order of events in biological

pathway, 2046 Bacteriophage Q/

Translation of bacteriophage Qf RNA by cytoplasmic extracts of mammalian cells, 315

Bacteriophage R17 Discriminatory ribosome rebinding of isolated regions of protein

synthesis initiation from ribonucleic acid of bacteriophage R17, 2605

Bacteriophage S13 Functional and structural integrity of messenger RNA, 2171

Bacteriophage T2 Experimental differential light-scattering correction to circular

dichroism of bacteriophage T2, 255 Bacteriophage T3

Ribonucleic acid polymerase, modification after T3 phage infection of Escherichia coli B, 2845

Bacteriophage T4 Association of rIIA protein with bacterial membrane, 1468 Direct participation of dCMP hydroxymethylase in synthesis of

bacteriophage T4 DNA, 2196 Head morphogenesis of bacteriophage T4: isolation, partial

characterization, and fate of gene 21-defective tau-particles, 1636

Ribonucleic acid, initiation of, with dinucleoside monophosphates during transcription of bacteriophage T4 DNA with RNA polymerase of Escherichia coli, 574

Ribosomal assembly influenced by growth in presence of streptomycin, 2762

Transfer RNA synthesis in vitro, 179 Bacteriophage T5

Phage-induced 5'-exonuclease, requirement for expression of late genes of bacteriophage T5, 3502

Ribonucleic acid polymerase binding sites of Escherichia coli, isolation on T5 and T7 DNA: further evidence for sigma-dependent recognition of A-T rich DNA sequences, 2911

Bacteriophage T7 Deoxyribonucleic acid-binding protein induced by bacteriophage

T7, 1846 Deoxyribonucleic acid-binding protein induced by bacteriophage

T7 (correction), 3007 Ribonucleic acid polymerase binding sites of Escherichia coli,

isolation on T5 and T7 DNA: further evidence for sigma-dependent recognition of A-T rich DNA sequences, 2911

T7 early RNAs are generated by site-specific cleavages, 1559 B:acteriophage 186


Bacteriophage 186 DNA, origin and direction of replication, 1768 Balbiani ring

Transport of 75S RNA from discrete chromosome region via nuclear sap to cytoplasm in Chironomus tentons, 442

BALB/3T3 cell Antigenic properties of endogenous type-C viruses from

spontaneously transformed clones of BALB/3T3, 1598 Bean

see Phaseolus Behavior genetics

Chromosomal control of mating activity in Drosophila pseudoobscura, 459

Behavior of organisms Cerebellum, evidence for higher functions: eating and grooming

elicited by cerebellar stimulation in cats, 2497 Countercurrent separation: new method for studying behavior of

small aquatic organisms, 1349 Benzene-indole sequence

Molecular orbital calculations of magnetic circular dichroism

6 Subject Index



Proc. Nat, Acad. Sci. USA 70 (1973)

spectra: benzene-indole sequence, 3754 Bergmann glia

Weaver mutant mouse cerebellum: defective neuronal migration secondary to abnormality of Bergmann glia, 240

BHK21 clone 13 cell Malignant transformation of BHK21 clone 13 cells in vitro by

nitrosamines: conditional state, 46 Malignant transformation of BHK21 clone 13 cells by BK virus: a

human papovavirus, 3210 Bicarbonate

Carbon dioxide and bicarbonate interaction with human hemoglobin preparations, 1414

Binary system Relation between X lines and phase separations, 1241

Binding of retinol Retinol, in vitro binding to rat-tissue components, 3483

Biocommunication Ultraviolet patterns on rear of flowers: basis of disparity of buds

and blossoms, 1002 Biological versatility

Biological versatility and earth history, 1936 Biology, electronic

Electronic biology (abstract), 2180 Bioluminescence

1,N6-Ethenoadenosine triphosphate and 1,NI-ethenoadenosine monophosphate, role in firefly luminescence, 1664

Spectral properties of oxygenated luciferase-flavin intermediate isolated by low-temperature chromatography, 3468

Synthesis of biologically active form of Renilla (sea pansy) luciferin, 120

Biomedical sciences From knowledge to action: science and its uses (Scientific

Program of National Academy of Sciences USA, Autumn 1973 Meeting), 3934

Biophysics Endotoxin potentiates responses associated with increases in

calcium conductance, 3301 Neuronal networks, theory of epigenesis by selective stabilization

of synapses, 2974 Ultrastructure of ferritin macromolecules: lattice structure of

core crystallites, 3847 Bisulfite

Molecular basis of biological function of molybdenum: relationship between sulfite oxidase and acute toxicity of bisulfite and SO2, 3655

Bis [o-xylyldithiolato-U2-sulfidoferrate (III)] Synthetic analogs of active sites of iron-sulfur proteins: structure

and properties of bis[o-xylyldithiolato-u2-sulfidoferrate (III)], an analog of 2Fe-2S proteins, 2429

BK virus Malignant transformation of BHK21 clone 13 cells by BK virus: a

human papovavirus, 3210 Black skipjack

see Euthynnus lineatus Bladder membrane, toad




Blood cell see also Leukocyte Amino acid, evidence of inter-organ transport by blood cells in

humans, 1775 Blood coagulation

Coagulation of blood plasma of guinea pig by bone matrix, 929 Membrane lipoprotein activation of proteolytic system:

mechanism of action of tissue factor, 310 Blood-gas relationship

Heat exchange in black skipjack, and blood-gas relationship of warm-bodied fishes, 1964

Blood group A N-Acetyl-D-galactosaminyltransferases produced by human Al

and A2 genes, qualitative differences, 220 Blood group Rh

Genetic model for Rh blood-group system, 1303 Blood plasma


Roles of calcium, serum, plasma, and folic acid in control of proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts, 675

Bohr effect, alkaline Measurement of pK values of alkaline Bohr group in human

hemoglobin, 1246 Bombyx mori

Transfer ribonucleic acid, biosynthesis of: in vitro conversion of transfer RNA precursors from Bombyx mori to 4S RNA by Escherichia coli enzymes, 2610

Bone Bone morphogenesis in implants of insoluble bone gelatin, 3511 Collagen synthesis: disulfide-linked collagen precursor in chick

bone, 2993 Disulfide-linked procollagen, identification as biosynthetic

precursor of chick-bone collagen, 3521

Subject Index 7

Bone marrow Erythrocytes, normal production by mouse marrow for 73

months, 3184 Hemoglobin ,-chain synthesis, regulation in bone marrow

erythroid cells by a chains, 3405 Bone-marrow culture

Hemoglobin switching in sheep and goats: erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures, 1739

Bone marrow-derived cell Cell interactions between histoincompatible T and B lymphocytes:

H-2 gene complex determines successful physiologic lymphocyte interactions, 2624

Immunoglobulin M, absence in enzymatically or biosynthetically labeled thymus-derived lymphocytes, 2879

Immunoglobulin synthesis and secretion by cells in mouse thymus that do not bear 0 antigen, 834

Immunological tolerance, induction in bone marrow-derived lymphocytes of IgE antibody class, 2776

Induction of immunoglobulin M synthesis and secretion in bone marrow-derived lymphocytes by locally concentrated concanavalin A, 416

Bone matrix Coagulation of blood plasma of guinea pig by bone matrix, 929

Botany Adenosine 3':5'-cyclic monophosphate in Chlamydomonas

reinhardtii: isolation and characterization, 1099 Biochemical basis of resistance of sugarcane to eyespot disease,

1693 8-Bromoadenosine 3':5'-cyclic monophosphate as promoter of cell

division in excised tobacco pith parenchyma tissue, 447 Chlorophyll composition and photochemical activity of

photosystems detached from chloroplast grana and stroma lamellae, 2082

Cytokinins, biosynthesis in cytokinin-autotrophic tobacco callus, 658

Light-induced phase shifts of circadian leaf movements of Phaseolus: comparison with effects of potassium and of ethyl alcohol, 3387

Photoreversible conductance changes induced by phytochrome in model lipid membranes, 762

Photosystem I chlorophyll-protein complex in greening leaves of higher plants, biosynthesis of, 134

Phytochrome, binding properties to membrane fraction in vitro, 3861

Polymorphism for interspecific cross-compatibility in Phlox, 1149 Programming of cells for death under defined experimental

conditions: relevance to tumor problem, 3055 Ultraviolet patterns on rear of flowers: basis of disparity of buds

and blossoms, 1002 Bovine-serum albumin

see Albumin, bovine-serum Bradykinin


Brain, calf Elongation factor 1, multiple forms from calf brain, 3282

Brain, cerebellum Cerebellum, evidence for higher functions: eating and grooming

elicited by cerebellar stimulation in cats, 2497 Plasma membranes, specific recognition by embryonic cells, 2794

Brain, chick embryo a- and j-Tublin, isolation and partial characterization from outer

doublets of sea-urchin sperm and microtubules of chick-embryo brain, 3594

Brain, choroid plexus -y-Glutamyl cycle in choroid plexus: its possible function in amino

acid transport, 1447 Brain, dentate gyrus

Synaptic rearrangement in dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats, 3473

Brain, guinea pig Microtubule assembly in the absence of added nucleotides, 765 Microtubule assembly in the absence of added nucleotides

(correction), 1903 Brain, ischemic necrosis of

Occlusion of brain capillaries by endothelial swelling in mycoplasma infections, 706

Brain lesions Synaptic rearrangement in dentate gyrus: histochemical evidence

of adjustments after lesions in immature and adult rats, 3473 Brain, rat



Opiate-receptor binding, properties in rat brain, 2243 Phenylethanolamine in brain and other tissues: demonstration

and distribution, 769 Stereospecific binding of potent narcotic analgesic [3H]etorphine

to rat-brain homogenate, 1947 Brain tumor, human

Particles with RNA of high molecular weight and RNA-directed DNA polymerase in human brain tumors, 2789

Brain, turkey Occlusion of brain capillaries by endothelial swelling in

mycoplasma infections, 706 Tropism of Mycoplasma gallisepticum for arterial walls, 1545




Brain, visual cortex Cats reared in stroboscopic illumination: effects on receptive

fields in visual cortex, 1353 Brdicka current

Polarographic catalytic,waves observed with bovine-serum albumin: kinetic or diffusion control, 2020

Polarographic catalytic waves observed with bovine-serum albumin: kinetic or diffusion control (correction), 2710

Breast tumor, huihan New DNA polymerase from human breast tumor cell iine HBT-3,

detection and isolation by (dT) 12-i8-cellulose chromatography, 2453

Bromamphenicol Mapping of Escherichia coli ribosorhal components involved in

peptidyl transferase activity, 1423 Brome mosaic viral ribonucleic acid

Translation of brome mosaic viral ribonucleic acid in cell-free system derived from wheat embryo, 1799

3-Bromo-2-butanone 1,4-bisphosphate 3-Bromo-2-butanone 1,4-bisphosphate as affinity label for

ribulosebisphosphate carboxylase, 3721 a-Bungarotoxin

Acetylcholine receptor and ion conductance modulator sites at murine neuromuscular junction: evidence from specific toxin reactions, 949

Acetylcholine receptor clusters on cultured muscle cells, 270 Plasma membranes from cultured muscle cells: isolation

procedure and separation of putative plasma-membrane marker enzymes, 3195

Burkitt's lymphoma Burkitt's tumors contain particles encapsulating RNA-instructed

DNA polymerase and high molecular weight virus-related RNA, 737

Deoxyribonucleic acid of Epstein-Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma, 3265

Deoxyribonucleic acid, unique nuclear sequences ih involved tissues of Hodgkin's and Burkitt's lymphomas, 3810

Malignant lymphomas of African children, 15 Ribonucleic acid related to that of murine leukemia virus in

Burkitt's tumors and nasopharyngeal carcinomas, 5 n-Butyl isocyanide

Nuclear magnetic resonance shift reagents: abnormal carbon-13 shifts produced by complexation of lanthanide chelates with saturated amines and n-butyl isocyanide, 562

Caenorhabditis elegans Chemotaxis by nematode Caenorhabditis elegans. identification of

attractants and analysis of response by use of mutants, 817 Calcium

Calcium ions, importance for regulation of guanosine 3':5'-cyclic monophosphate levels, 3889

Membrane sealing in frog skeletal-muscle fibers, 982 Membrane sealing in frog skeletal-muscle fibers (addendum),

3007 Nucleoside cyclic 3':5'-monophosphate phosphodiesterase activity

from rat brain, regulation by modulator ahd Ca2+, 3526 Roles of calcium, serum, plasma, and folic acid in control of

proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts, 675

Calcium absorption LT-Hydroxycholecalciferol, synthetic analog of hormonal form of

vitamin D3: biological activity, 2248 Calcium conductance

Endotoxin potentiates responses associated with increases in t calcium conductance, 3301

Calcium transport Ca2+ transport by mitochondria from L1210 mouse ascites tumor

cells, 1744 Ruthenium Red, inhibitory action on neuromuscular

transmission, 3613 Camphor

Transmissible plasmid controlling camphor oxidation in Pseudomonas putida, 885

Camphor degradative pathway Genetic fusion of incotnpatible plasmids in Pseudomonas, 1641

Cancer see also Carcinoma; 'teratocarcinoma

Cancer diagnosis Radioimmunoassay for human alpha1-fetoprotein, 526

Cancer, human Herpes simplex and genitalis virus nonvirion antigens: use for

determining possible role of viruses in etiology of some human cancers (abstract), 2179

Herpes simplex and herpes genitalis viruses in etiology of some human cancer, 3225

Capillary, brain Occlusion of brain capillaries by endothelial swelling in

mycoplasma infections, 706 Carbamino


Carbamylphosphate synthetase Glutaminase activity of glutamine amidotransferase

(carbamylphosphate synthetase), pH dependence, 2717 Carbohydrate

Adhesion of cultured fibroblasts to insoluble analogues of cell-surface carbohydrates, 2309

Dictyostelium discoideum, developmentally regulated,

carbohydrate-binding protein in, 2554 Mobility of carbohydrate-containing structures on surface

membrane and normal differentiation of myeloid leukemic cells to macrophages and granulocytes, 2577

Sugar effects on murine sarcoma virus transformation, 1364 Carbohydrate catabolism

Carbohydrate catabolism and enhancement of uptake of galactose in hamster cells transformed by polyoma virus, 839

Carbohydrate transport Galactoside, proton-coupled accumulation in Streptococcus

lactis 7962, 2866 Carbonate dehydratase

see Carbonic anhydrase Carbon dioxide


Carbon dioxide hydration activity of carbonic anhydrase: paradoxical consequences of unusually rapid catalysis, 1986

Carbonic anhydrase Carbon dioxide and bicarbonate interaction with human

hemoglobin preparations, 1414 Carbonic anhydrase (EC 4.2.1.1)

Carbon dioxide hydration activity of carbonic anhydrase: paradoxical consequences of unusually rapid catalysis, 1986

Catalytic mechanism of carbonic anhydrase, 2505 Carbon monoxide

Interpretation of binding of carbon monoxide to hemoglobin under photodissociating conditions, 673

Carbonyl Charge transfer between amine and carbonyl, 3139

Carboxypeptidase A Carboxypeptidase A's, enzymatic activities in solution and in

crystals, 3797 Ground states of cobait(II) and nickel(II) carboxypeptidase A, 161

Carboxypeptidase B Tyrosyl residue, role in mechanism of action of carboxypeptidase

B: luminescence studies, 2025 Carcinogen

see also Transformation of animal cells by chemical 5-Bromo-2'-deoxyuridine potentiation of transformation of

rat-embryo cells induced in vitro by 3-methylcholanthrene: induction of rat leukemia virus gs antigen in transformed cells, 2415

Carcinogen-induced chromosomal breakage decreased by antioxidants, 1461

Carcinogens are mutagens: simple test system combining liver homogenates for activation and bacteria for detection, 2281

Improved bacterial test system for detection and classification of mutagens and carcinogens, 782

Improved bacterial test system for detection and classification of mutagens and carcinogens (correction), 1903

Carcinogenesis see also Transformation of animal cells; Tumorigenesis

Carcinogenesis, general theory Carcinogenesis, general theory, 3324

Carcinoma see also Cancer; Teratocarcinoma

Carcinoma, bronchogenic Subunits of human chorionic gonadotropin: unbalanced synthesis

and secretion by clonal cell strains derived from bronchogenic carcinoma, 1419

Carcinoma, embryonal Alkaline phosphatase activity in mouse teratoma, 3899

Carcinoma, nasopharyngeal Deoxyribonucleic acid of Epstein-Barr virus detected in tissue of

Burkitt's lymphoma and nasopharyngeal carcinoma, 3265 Ribonucleic acid related to that of murine leukemia virus in

Burkitt's tumors and nasopharyngeal carcinomas, 5 Carcinoma, rat mammary

Rat mammary carcinoma in vivo and in vitro: establishment of clonal lines of tumor, 1922

Cardiac muscle Immobilized catecholamine and cocaine, effects of, on

contractility of cardiac muscle, 1214 Myocardial myosin, regulatory properties, 3205

Carrier protein Squalene and sterol carrier protein: structural properties,

lipid-binding, and function in cholesterol biosynthesis, 265 Catabolite activator protein


Catalysis, acid-base Carbon dioxide hydration activity of carbonic anhydrase:

paradoxical consequences of unusually rapid catalysis, 1986 Catalytic constant

Leaving-group electronic effect, influence on a-chymotrypsin: catalytic constants of specific substrates, 517

Catalytic wave see Polarographic catalytic wave

Catecholamine see also Chromaffin granule Catecholamine transmitter regulates supersensitivity and

subsensitivity of /-adrenergic receptor in pineal gland, 2411 Immobilized catecholamine and cocaine, effects of, on

contractility of cardiac muscle, 1214 Pineal indole biosynthesis, control of by changes in sympathetic

tone caused by factors other than environmental lighting, 1704 Caucasian-Negro

Confirmation of Negro economic gains on whites and




identification of dysgenic subpopulations by "offset analysis" (abstract), 3935

Deviations from Hardy-Weinberg frequencies caused by assortative mating in hybrid populations, 732

Deviations from Hardy-Weinberg frequencies caused by assortative mating in hybrid populations (correction), 1903

How biased are culture-loaded tests? (abstract), 3935 Mathematical models for assortative mating in American Negro

populations resulting in correlation between fractions of Caucasian ancestry (abstract), 1619

Variance of Caucasian admixture in Negro populations, pigmentation variability, and IQ (abstract), 2180

Caulobacter crescentus Messenger selection by bacterial ribosomes, 2364

C4-Dicarboxylic acid cycle Oxaloacetate as Hill oxidant in mesophyll cells of plants

possessing C4-dicarboxylic acid cycle of leaf photosynthesis, 3730

Cell adhesion Membrane sites in aggregating Dictyostelium cells, quantitation

by use of tritiated univalent antibody, 3150 Plasma membranes, specific recognition by embryonic cells, 2794 Quantitative assay for intercellular adhesion, 1569

Cell agglutination Cell contact-dependent increase in membrane

D-galactopyranosyl-like residues on normal, but not virus- or spontaneously-transformed, murine fibroblasts, 1672

Cell-aggregating factor Cell-surface interactions: differential inhibition by proflavine of

embryonic cell aggregation and production of specific cell-aggregating factor, 3111

Cell aggregation Dictyostelium plasma membranes, response to adenosine

3':5'-cyclic monophosphate, 1630 Membrane sites in aggregating Dictyostelium cells, quantitation

by use of tritiated univalent antibody, 3150 Cell behavior

Modulation of cell behavior in vitro by substratum in fibroblastic and leukemic mouse cell lines (correction), 284

Preservation of normal behavior by enucleated cells in culture, 750

Cell contact Cell contact-dependent increase in membrane


Cell contact model for cellular position determination in development, 2396

Interrelationship between adenylate cyclase activity, adenosine 3':5'-cyclic monophosphate phosphodiesterase activity, adenosine 3':5'-cyclic monophosphate levels, and growth of cells in culture, 3802

Membrane structure, changes associated with cell contact, 3631 Cell cycle

Cell cycle changes and the ability of cells to undergo virus-induced fusion (correction), 965

Cell division Actin in dividing cells: contractile ring filaments bind heavy

meromyosin, 1688 8-Bromoadenosine 3':5'-cyclic monophosphate as promoter of cell

division in excised tobacco pith parenchyma tissue, 447 3-Methylgalactoside transport system and galactose-binding

protein, regulation by cell cycle of Escherichia coli, 1481 Tobacco pith cells, habituation for factors promoting cell division

is heritable and potentially reversible, 2660 Cell elongation

Cell elongation and microtubule assembly, stimulation of, by insulin in embryonic chick-lens epithelia, 1195

Cell, enucleated Preservation of normal behavior by enucleated cells in culture,

750 Cell, eukaryotic

Absence of sequence G-T-l-C-G(A)- in several eukaryotic cytoplasmic initiator transfer RNAs, 1041

Absence of sequence G-T-6-C-G-(A)- in several eukaryotic cytoplasmic initiator transfer RNAs (correction), 3274

Cell, fat Affinity binding of intact fat cells and their ghosts to immobilized

insulin, 792 Cell fusion

Hypoxanthine phosphoribosyltransferase activity, restoration in mouse 1R cells after fusion with chick-embryo fibroblast, 1998

Cell growth Concanavalin A, maximal specific agglutinability without loss of

density-dependent growth control, 2676 Cell hybrid

see Hybrid cell Cell interaction

Cell interactions between histoincompatible T and B lymphocytes: H-2 gene complex determines successful physiologic lymphocyte interactions, 2624

Neuronal connections in isogenic organisms: cellular interactions in development of optic lamina of Daphnia, 433

Cell kinetics Do cells cycle? 1263

Cell, malignant see also Transformation of animal cells Malignant cells, altered growth behavior associated with changes

in externally labeled glycoprotein and glycolipid, 3329 Trypsinized normal cells, reactivity with antibody presumably

Subject Index 9

specific for malignant cells, 325 Cell, mammalian

see also Mutant of mammalian cells Electron spin resonance studies of spin-labeled mammalian cells

by detection of surface membrane signals, 66 Hemin effect on synthesis of hemoglobin and other proteins in

mammalian cells, 1022 Temperature-sensitive mutation affecting 28S ribosomal RNA

production in mammalian cells, 1273 Cell membrane

see Membrane, cell Cell, mesodermal

Chondrogenic expression, control of in mesodermal cells of embryonic chick limb, 1713

Cell, mesophyll Oxaloacetate as Hill oxidant in mesophyll cells of plants


Cell migration Transformed cell line factor that affects cell migration, 369

Cell monolayer, confluent Quantitative assay for intercellular adhesion, 1569

Cell nucleus Hybridization of leucyl-transfer ribonucleic acid isoacceptors

from green leaves with nuclear and chloroplast deoxyribonucleic acid, 3498

Initiation and continuation of DNA replication are not associated with nuclear envelope in mammalian cells, 714

Nucleolar proteins of normal rat liver, comparison with Novikoff hepatoma ascites cells by two-dimensional polyacrylamide gel electrophoresis, 1316

Cell shape Cell envelope and shape of Escherichia coli K12, 2033

Cell surface Adhesion of cultured fibroblasts to insoluble analogues of

cell-surface carbohydrates, 2309 Adhesive recognition and retinotectal specificity, 2482 Antibodies with multiple binding functions: induction of single

immunoglobin species by structurally dissimilar haptens, 3269 Cell-surface glycoproteins of mouse embryos: change before

implantation, 1645 Cell-surface immunoglobulin of human thymus cells and its

biosynthesis in vitro, 3716 Cell-surface interactions: differential inhibition by proflavine of


Cell-surface proteins, alteration by viral transformation and by proteolysis, 3170

Surface changes in temperature-sensitive simian virus 40-transformed cells, 347

Temperature-induced variations in surface topology of cultured lymphocytes are revealed by scanning electron microscopy, 2492

Wet chemical method for rendering scanning electron microscopy samples conductive and observations on surface morphology of human erythrocytes and Ehrlich ascites cells, 3599

Cell, 3T3 see Mutant of 3T3 cell

Cell volume Contraction of isolated smooth-muscle cells: structural changes,

641 Central nervous system

Oligoclonal immunoglobulin G antibody response in central nervous system to different measles virus antigens in subacute sclerosing panencephalitis, 1060

Strychnine binding associated with glycine receptors of central nervous system, 2832

Centromere Relative orientation with respect to centromere of ribosomal RNA

genes of X and Y chromosomes of Drosophila melanogaster, 1883

Cerebellum Cerebellum, evidence for higher functions: eating and grooming

elicited by cerebellar stimulation in cats, 2497 Plasma membranes, specific recognition by embryonic cells, 2794 Weaver mutant mouse cerebellum: defective neuronal migration

secondary to abnormality of Bergmann glia, 240 CERN

see European Organization for Nuclear Research Cesium sulfate

Cesium sulfate gradients that contain both Hg2+ and Ag+ effect complete separation of satellite deoxyribonucleic acids having identical densities in neutral cesium chloride gradients, 3108

Chelate, lanthanide Nuclear magnetic resonance shift reagents: abnormal carbon-13

shifts produced by complexation of lanthanide chelates with saturated amines and n-butyl isocyanide, 562

Chemical kinetics Fluctuation spectroscopy: determination of chemical reaction

kinetics from frequency spectrum of fluctuations, 870 Chemically disparate system

Stereochemical correspondence among chemically disparate systems: spirocyclic phosphoranes, diarylmethanes, and cognates, 3445

Chemically induced dynamic nuclear polarization Photooxidation of chlorophyll b by quinones studied by

chemically-induced dynamic nuclear polarization, 143 Chemotaxis

5'-Adenosine monophosphate-dependent adenylate cyclase and





Chemotaxis by nematode Caenorhabditis elegans: identification of attractants and analysis of response by use of mutants, 817

Countercurrent separation: new method for studying behavior of small aquatic organisms, 1349

Chinese hamster ovary cell see also Mutant of Chinese hamster ovary cell Initiation and continuation of DNA replication are not associated

with nuclear envelope in mammalian cells, 714 Chironomus tentans

Transport of 75S RNA from discrete chromosome region via nuclear sap to cytoplasm in Chironomus tentans, 442

Chlamydomonas see also Mutant of Chlamydomonas reinhardtii Adenosine 3':5'-cyclic monophosphate in Chlamydomonas

reinhardtii: isolation and characterization, 1099 Altered chloroplast ribosomal proteins associated with

erythromycin-resistant mutants in two genetic systems of Chlamydomonas reinhardi (correction), 2176

Attachment of chloroplast polysomes to thylakoid membranes in Chlamydomonas reinhardtii, 1554

Chloramphenicol-binding protein Chloramphenicol-binding protein, identification in Escherichia

coli ribosomes by partial reconstitution, 2224 Chloramphenicol-binding protein, identification in Escherichia

coli ribosomes by affinity labeling, 2229 Chloramphenicol, N-bromoacetyl

Mapping of Escherichia coli ribosomal components involved in peptidyl transferase activity, 1423

Chlorophyll Chlorophyll composition and photochemical activity of


Coupling between bacteriochlorophyll and membrane protein synthesis in Rhodopseudomonas spheroids, 799

Photophosphorylation by monomolecular films at air-water interface, 50


Chlorophyll a Allophycocyanin as light-harvesting pigment in cyanobacteria,

3130 Chlorophyll b

Photooxidation of chlorophyll b by quinones studied by chemically-induced dynamic nuclear polarization, 143

Chloroplast see also Photosystem; Ribosome, chloroplast Attachment of chloroplast polysomes to thylakoid membranes in

Chlamydomonas reinhardtii, 1554 Can non-Mendelian mutation affect both chloroplast and

mitochondrial ribosomes? 3463 Chlorophyll composition and photochemical activity of


Cytoplasmic regulatory mutant of Euglena: constitutivity for light-inducible chloroplast transfer RNAs, 1749

Free radical detection in primary reaction of chloroplast photosystem II, 294

Hybridization of leucyl-transfer ribonucleic acid isoacceptors from green leaves with nuclear and chloroplast deoxyribonucleic acid, 3498

Hydrogen evolution by chloroplast-ferredoxin-hydrogenase system, 2317

Choleragen Adrenal tumor cells, stimulation of steroid secretion by

choleragen, 2741 Cholera toxin


Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin, 2964

Cholesterol Cholesterol, self-association in aqueous solution, 2313 Elongation factor 1, multiple forms from calf brain, 3282 Familial hypercholesterolemia: identification of defect in

regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol, 2804

3-Hydroxy-3-methylglutaryl coenzyme A reductase activity, regulation in human fibroblasts by lipoproteins, 2162


Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis, 265

Choline acetyltransferase (EC 2.3.1.6) Choline acetyltransferase of squid-head ganglia, purification, 3749 Cycloheximide and acetoxycycloheximide: inhibition of tyrosine

hydroxylase activity and amnestic effects, 354 Cholinergic agent


Cholinergic neurone Cytochalasin blocks sympathetic ganglionic transmission:

presynaptic effect antagonized by pyruvate, 1730 Cholinergic receptor

Acetylcholine-like molecular arrangement in psychomimetic anticholinergic drugs, 3103

Snake a-neurotoxin, effects on development of innervated skeletal

muscles in chick embryo, 1708 Chondrogenesis

Chondrogenesis in limb-bud cell cultures, control with bromodeoxyuridine, 2201

Chondrogenic expression Chondrogenic expression, control of in mesodermal cells of

embryonic chick limb, 1713 Chorionic gonadotropin

Subunits of human chorionic gonadotropin: unbalanced synthesis and secretion by clonal cell strains derived from bronchogenic carcinoma, 1419

Choroid plexus -y-Glutamyl cycle in choroid plexus: its possible function in amino

acid transport, 1447 Chromaffin granule

see also Catecholamine Circular dichroism of chromaffin granule proteins in situ:

analysis of turbidity effects and protein conformation, 3458 Chromatin

see also Chromosome Chromatin acidic proteins with high affinity for deoxyribonucleic

acid: some binding parameters, 2524 Deoxyribonucleic acid in chromatin, accessibility to DNA

polymerase and RNA polymerase, 1326 Globin gene, tissue-specific transcription in isolated chromatin,

3440 Globin ribonucleic acid, synthesis from duck-reticulocyte

chromatin in vitro, 2029 Histones, blocking of accessibility to DNA in chromatin: addition

of histones (correction), 627 In vitro transcription of viral-specific sequences present in

chromatin of cells transformed by simian virus 40, 3506 Pineal protein kinase: effect of enzymic phosphorylation on


Selective extraction of histones, effects on template activities of chromatin by use of exogenous DNA and RNA polymerases, 1973

Simian virus 40 sequences, in vitro transcription in SV3T3 chromatin, 2304

Transcription of rat-liver chromatin with homologous enzyme, 1161

Chromatography, affinity DL-Tryptophan, resolution by affinity chromatography on

bovine-serum albumin-agarose columns, 2850 Mouse interferon, purification of, by affinity chromatography on

solid-phase immunoadsorbent, 1037 Chromatography, (dT) 12-18-cellulose

New DNA polymerase from human breast tumor cell line HBT-3, detection and isolation by (dT) 12.l8-cellulose chromatography, 2453

Chromatography, high resolution liquid New natural insect juvenile hormone from Manduca sexto:

isolation, structure, and absolute configuration, 1509 Chromatography, hydrophobic

Hydrophobic chromatography: use for purification of glycogen synthetase, 778

Chromatography, intervent dilution Intervent dilution chromatography: concept for separation of

strongly interacting macromolecules, 2424 Chromatography, low-temperature


Chromatography, sievorptive Intervent dilution chromatography: concept for separation of

strongly interacting macromolecules, 2424 Chromomere


Chromosomal breakage Carcinogen-induced chromosomal breakage decreased by

antioxidants, 1461 Chromosomal polymorphism

Temporal frequency changes of enzyme and chromosomal polymorphisms in natural populations of Drosophila, 680

Temporal frequency changes of enzyme and chromosomal polymorphisms in natural populations of Drosophila (correction), 2176

Chromosome see also Chromatin Chick chromosomes, identification in cell hybrids formed between

chick erythrocytes and adenine-requiring mutants of Chinese hamster cells, 2893

"Early" virus-specific RNA may contain information necessary for chromosome replication and mitosis induced by simian virus 40, 1654

Yeast chromosomal deoxyribonucleic acid size and structure, 3072

Chromosome abnormality Chromosomal abnormalities in spleens of New Zealand Black

mice: strain characterized by autoimmunity and malignancy, 1094

Chromosome banding Chromosome structure as revealed by combined chemical and

immunochemical procedure, 804 Chromosome C-7, human

T-antigen gene of simian virus 40, assignment to human chromosome C-7, 3617

10 Subject Index




Chromosome, human Deoxyribonucleic acid replication, microfluorometric detection in

human metaphase chromosomes, 3395 Loci for human PGM1 and 6PGD, regional localization on human

chromosome one by use of hybrids of Chinese hamster-human somatic cells, 2737

RD114-virus RNA, in situ hybridization with human metaphase chromosomes, 11

Chromosome inactivation see Lyon hypothesis

Chromosome, mammalian Deoxyribonucleic acid replication in mammalian chromosomes:

isolation of replicating segments, 1083 Chromosome, metaphase

Iodine-125-labeled DNA-RNA hybrids in cytological preparations, 1536

Transfer of genetic information by purified metaphase chromosomes, 1258

Chromosome, Philadelphia Carcinogenesis, general theory, 3324

Chromosome, polytene Independent control of ribosomal gene replication in polytene

chromosomes of Drosophila melanogaster, 1359 Chromosome replication

Chromosome replication during meiosis: identification of gene functions required for premeiotic DNA synthesis, 3087

Chromosome, sex Independent control of ribosomal gene replication in polytene

chromosomes of Drosophila melanogaster, 1359 Chromosome structure

Chromosome structure as revealed by combined chemical and immunochemical procedure, 804

Chromosome, X Crossing-over between X and Y chromosomes during ribosomal

DNA magnification in Drosophila melanogaster, 1950 Deoxyribonucleic acid replication, microfluorometric detection in

human metaphase chromosomes, 3395 Human regulatory gene for inducible tyrosine aminotransferase

in rat-human hybrids, 1268 Hypoxanthine phosphoribosyltransferase, reexpression of rat

gene in rat-human hybrids, 2590 Inactivation system of the mammalian X chromosome, 195 Relative orientation with respect to centromere of ribosomal RNA


Chromosome, Y Crossing-over between X and Y chromosomes during ribosomal

DNA magnification in Drosophila melanogaster, 1950 Relative orientation with respect to centromere of ribosomal RNA


Repeated DNA sequences in heterochromatic Y chromosome of adult Drosophila melanogaster, 773

Chylomicron Primary dysbetalipoproteinemia: predominance of specific

apoprotein species in triglyceride-rich lipoproteins, 2015 c-Chymotrypsin


Ciliary body y-Glutamyl cycle, enzymes in ciliary body and lens, 2211

Ciliary inhibition Cystic fibrosis: fractionation of fibroblast media that inhibits

ciliary activity, 548 Ciliary structure

Setae of first antennae of copepod Cyclops scutifer (Sars): structure and importance, 2656

Circadian cycle Circadian oscillations, general homeostasis of frequency, 2697 Differential effect of heavy water on temperature-dependent and

temperature-compensated aspects of circadian system of Drosophila pseudoobscura, 2037


Circular dichroism Alteration of relative stability of dA-dT and dG-dC base pairs in

DNA, 298 Circular dichroism of chromaffin granule proteins in situ:

analysis of turbidity effects and protein conformation, 3458 Cobalt bovine procarboxypeptidase A spectrum: index of catalytic

function (correction), 284 Conformations of arsanilazotyrosine-248 carboxypeptidase A:

comparison of crystals and solution, 2006 Experimental differential light-scattering correction to circular

dichroism of bacteriophage T2, 255 Membrane optical activity: some facts and fallacies, 3235 Molecular orbital calculations of magnetic circular dichroism

spectra: benzene-indole sequence, 3754 Citrate synthase (EC 4.1.3.7)

Immobilized three-enzyme system: model for microenvironmental compartmentation in mitochondria, 2534

Class-number "Metodo rapido" for finding real quadratic fields of

class-number 1, 395 Clonal line, establishment of

Rat mammary carcinoma in vivo and in vitro: establishment of clonal lines of tumor, 1922

Subject Index 11

Clone, abnormal Congenital neutropenia: in vitro growth of colonies mimicking the

disease, 669 Clostridium MP

Proton magnetic resonance spectra, dependence on oxidation state of flavodoxin from Clostridium MP and from Peptostreptococcus elsdenii, 3292

Clostridium pasteurianum Electron paramagnetic resonance of nitrogenase and nitrogenase


Cloud-seeding Downwind and upwind effects in Arizona cloud-seeding

experiment, 357 Cobalt

Cobalt bovine procarboxypeptidase A spectrum: index of catalytic function (correction), 284

Ground states of cobalt(II) and nickel(II) carboxypeptidase A, 161 Cobalt acetylacetonate

Nuclear magnetic resonance shift reagents: evidence for different mechanisms of contact contributions to carbon-13 shifts induced by nickel and cobalt acetylacetonates with saturated amines and alcohols, 939

Cobaltohemoglobin Stereochemical trigger for initiating cooperative interaction of

subunits during oxygenation of cobaltohemoglobin, 3919 Cocaine

see also Narcotic; Heroin Immobilized catecholamine and cocaine, effects of, on

contractility of cardiac muscle, 1214 Cockroach

see Leucophaea maderae Codon

lac repressor fragment, reinitiation at codon other than AUG, 3165

Protein Hal: partial deletion of "y" immunoglobulin gene(s) and apparent reinitiation at internal AUG codon, 1073

Coenzyme A see Acyl-coenzyme A

Coenzyme A transferase see 3-Ketoacid CoA-transferase

Coenzyme binding Alcohol dehydrogenase of liver: structure at 2.9 angstrom

resolution, 2439 Coenzyme Qio

Stimulation of host defense system by coenzyme Qio, effect on dibenzpyrene-induced tumors and infection with Friend leukemia virus in mice, 390

Cofactor-enzyme interaction Conformations of diphosphopyridine coenzymes upon binding to

dehydrogenases, 1593 Colcemid

Cell cycle changes and the ability of cells to undergo virus-induced fusion (correction), 965


Colchicine Cell elongation and microtubule assembly, stimulation of, by

insulin in embryonic chick-lens epithelia, 1195 Cold environment

Changes in rabbit-liver lysosomes and fructose 1,6-bisphosphatase induced by cold and fasting, 3674

Cold-sensitive mutant see also Temperature-sensitive mutant Genetic method for determining order of events in biological

pathway, 2046 Coleoptile


Colicin E3 Colicin E3: unique endoribonuclease, 156 Colicins E3 and K resistance, induced by infection with

bacteriophage fl, 3160 Colicin K

Colicin K of Escherichia coli K235, 854 Colicins E3 and K resistance, induced by infection with

bacteriophage fl, 3160 Collagen

see also Procollagen Amino-terminal extension in high-molecular-weight collagens

from mature bovine skin, 1464 Cell-free synthesis of procollagen: L-929 fibroblasts as cellular

model for dermatosparaxis, 1378 Collagen and procollagen production by clonal line of Schwann

cells, 1943 Collagen synthesis: disulfide-linked collagen precursor in chick

bone, 2993 Disulfide-linked procollagen, identification as biosynthetic

precursor of chick-bone collagen, 3521 Prolyl hydroxylase activation in L-929 fibroblasts by ascorbic

acid, 1090 Collagen, tendon

Coagulation of blood plasma of guinea pig by bone matrix, 929 Colloidal particle

Thermal motion and forced migration of colloidal particles generate hydrostatic pressure in solvent, 124

Competition Competition among plants (N.A.S. Symposium: plant growth

regulation), 585




Global models of growth and competition, 3590 Complement

Cytogenetic engineering in vivo: restoration of biologic complement activity to C5-deficient mice by intravenous inoculation of hybrid cells, 3125

Histocompatibility-2-linked Ss-Slp region, role in control of mouse complement, 863

Human complement, activation by human lymphoid cells sensitized with histocompatibility alloantisera, 3665

Lysosomal enzyme, mechanisms of release from human leukocytes: microtubule assembly and membrane fusion induced by component of complement, 2916

Complement component 1-bypass activation pathway New complement-mediated cytolytic mechanism: Cl-bypass

activation pathway, 649 Computer determination

Nonheuristic computer determination of molecular structure based upon carbon-13 nuclear magnetic resonance data: branched alkanes, 3419

Computer simulation Computation of large molecules with Hartree-Fock model

(correction), 284 Ion transport across nerve membrane: cooperativity between

channels of large square lattice, 62 Concanavalin A

Carbon-13 enriched a-methyl-D-glucopyranoside binding to concanavalin A as studied by carbon magnetic resonance, 1007

Concanavalin A-binding sites, comparative evaluation of distribution on surfaces of normal, virally-transformed, and protease-treated fibroblasts, 1625

Concanavalin A derivatives with altered biological activities, 1012

Concanavalin A, maximal specific agglutinability without loss of density-dependent growth control, 2676


Induction of lymphocyte transformation by sequential treatment with neuraminidase and galactose oxidase, 1824


Membrane changes and adenosine triphosphate content in normal and malignant transformed cells, 1780

Nearest-neighbor amino acids, influence on conformation of middle amino acid in proteins: comparison of predicted and experimental determination of /3-sheets in concanavalin A, 1473

Purification of oncornaviruses by agglutination with concanavalin A, 1308

Solvent proton magnetic relaxation dispersion in solutions of concanavalin A, 475


Conformation see also Protein conformation e-Adenylated glutamine synthetase: internal fluorescence probe

for enzyme conformation, 3134 Alcohol dehydrogenase of liver: structure at 2.9 angstrom

resolution, 2439 Circular dichroism of chromaffin granule proteins in situ:

analysis of turbidity effects and protein conformation, 3458 Conformational analysis of thyrotropin releasing factor, 1456 Conformational control of interaction of eukaryotic elongation

factors EF-1 and EF-2 with ribosomes, 3556 Conformation Li-antamanide complex and Na-[Phe4,

Val6]antamanide complex, in crystalline state, 1836 Conformation of charged and uncharged tRNAP"e, 2193 Conformations of arsanilazotyrosine-248 carboxypeptidase A:

comparison of crystals and solution, 2006 Disulfide bond dihedral angles from Raman spectroscopy, 2619 Medium-range interactions, role in proteins, 830 Neutral to alkaline conversion of liver fructose

1,6-bisphosphatase: changes in molecular properties of enzyme, 661

Neutron diffraction structure of melampodin: its role in reclassification of germacranolides, 2434

Neutron diffraction structure of melampodin: its role in reclassification of germacranolides (correction), 3932

Oxytocin, 300-MHz nuclear magnetic resonance study in aqueous solution: conformational implications, 3806

Sodium deoxyribonucleate, direct evidence for C-like form of, 3352

Y base, effect of removal on conformation of yeast tRNA'he, 3843

Congenital neutropenia Congenital neutropenia: in vitro growth of colonies mimicking the

disease, 669 Connective tissue

Bound form of silicon in glycosaminoglycans and polyuronides, 1608

Construction of plasmid Construction of biologically functional bacterial plasmids in vitro,

3240 Contact inhibition

Contact inhibition of movement in cultures of transformed cells, 2011


Transformed cell line factor that affects cell migration, 369

Contractile protein Relatedness among contractile and membrane proteins: evidence

for evolution from common ancestral genes, 3230 Contractile ring filaments of HeLa cell


Copper protein Magnetic dipole-dipole coupled Cu(II) pairs in nitric oxide-treated

tyrosinase: structural relationship between active sites of tyrosinase and hemocyanin, 993

Coral Wax in coral mucus feeds tropical reef fishes (abstract), 3935

Correction Membrane sealing in frog skeletal-muscle fibers (addendum),

3007 Corrections

Absence of sequence G-T-4-C-G-(A)- in several eukaryotic cytoplasmic initiator transfer RNAs, 3274

Acetylcholine biosynthesis in turtle photoreceptors, 284 Acetylcholine receptors, regulation in relation to

acetylcholinesterase in neuroblastoma cells, 3932 Altered chloroplast ribosomal proteins associated with

erythromycin-resistant mutants in two genetic systems of Chlamydomonas reinhardi, 2176

Amino acid sequence of dogfish M4 lactate dehydrogenase, 2467 Avian myeloblastosis virus, single subunit with both


Cell cycle changes and the ability of cells to undergo virus-induced fusion, 965

Cobalt bovine procarboxypeptidase A spectrum: index of catalytic function, 284

Computation of large molecules with Hartree-Fock model, 284 Deoxyribonucleic acid-binding protein induced by bacteriophage

T7, 3007 Deviations from Hardy-Weinberg frequencies caused by

assortative mating in hybrid populations, 1903 Electron paramagnetic resonance of nitrogenase and nitrogenase

components from Clostridium pasteuria~num W5 and Azotobacter vinelandii OP, 627

Endogenous RNA-dependent DNA polymerase activity in uninfected chicken embryos, 284

Histones, blocking of accessibility to DNA in chromatin: addition of histones, 627

Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in family with gout and excessive purine synthesis, 3932


Ion-diffusion potentials and electrical rectification across lipid membranes activated by excitation-induced material, 1284

Microtubule assembly in the absence of added nucleotides, 1903 Modulation of cell behavior in vitro by substratum in fibroblastic

and leukemic mouse cell lines, 284 Natural host toxonomy of RNA tumor viruses, determination by

molecular hybridization: application to RD-114, a candidate human virus, 2176


Nuclear DNA sequences present in human leukemic cells and absent in normal leukocytes, 627

Nucleotide modification in vitro of precursor of transfer RNATYr of Escherichia coli, 3932


Polarographic catalytic waves observed with bovine-serum albumin: kinetic or diffusion control, 2710

Ribonucleic acid-linked DNA fragments in vitro, 1284 Ribosomes crosslinked with dimethylsuberimidate: structural and

functional properties, 1618 Rod-shaped virus assembly in vitro: reconstitution with cucumber

green mottle mosaic virus protein and tobacco mosaic virus RNA, 1618

Sequence of spontaneous Epstein-Barr virus activation and selective DNA synthesis in activated cells in presence of hydroxyurea, 284

Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture, 3932


Corticosteroid see also Glucocorticoid hormone Adrenal corticosteroids enhance production of type-C virus

induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts, 2391

Endotoxin potentiates responses associated with increases in calcium conductance, 3301

Corynebacterium fascians cis-Zeatin, isolation from Corynebacterium fascians cultures,

3825 Countercurrent separation, new method


Covalent enzyme-substrate binding Covalent enzyme-substrate bond activation by noncovalent

interaction with an effector, 2077 Crab

see Grapsus; Pagurus pollicaris

12 Subject Index




Crayfish see Procambarus

Creatine kinase Protein that binds specifically to M-line of skeletal muscle is

identified as muscle form of creatinine kinase, 702 Creatine kinase (EC 2.7.3.2)

Substrate binding to active creatine kinase with thiol-bound mercurinitrophenol chromophoric probe, 2858

Cross-compatibility Polymorphism for interspecific cross-compatibility in phlox, 1149

Cryobiology Scanning transmission electron microscope studies of deep-frozen

unfixed muscle correlated with spatial localization of intracellular elements by fluorescent x-ray analysis, 3423

Cryotomy, ultra- Immunoferritin localization of intracellular antigens: use of

ultracryotomy to obtain ultrathin sections suitable for direct immunoferritin staining, '649

Crystallin synthesis' Cell elongation and microtubule assembly, stimulation of, by

insulin in embryonic chick-lens epithelia, 1195 Crystallography

see X-ray crystallography C-type virus

Adrenal corticosteroids enhance production of type-C virus induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts, 2391

Antigenic properties of endogenous type-C viruses from spontaneously transformed clones of BALB/3T3, 1598

Chromosomal abnormalities in spleens of New Zealand Black mice: strain characterized by autoimmunity and malignancy, 1094

Common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses, 1878

Host-gene control of type-C RNA tumor virus expression and tumorigenesis in inbred mice, 1450

Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells, 2065

Ribonucleic acid-dependent deoxyribonucleic acid polymerase in type C viruses: specificity of DNA product II, quantitative analysis, 3923

Type-C viruses of various species, hoihology as determined by molecular hybridization, 3316

Type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum, 859

Viral DNA polymerase in mouse milk: characterization and separation, 2117,

Cucumber green mottle mosaic virus protein Rod-shaped virus assembly in vitro: reconstitution with cucumber

green mottle mosaic virus protein and tobacco mosaic virus RNA (correction), 1618

Curvature, higher-order Higher-order curvature and local solvability of Do, 797

Cyanobacteria Allophycocyanin as light-harvesting pigment in cyanobacteria,

3130 Cyclic AMP

see Adenosine 3':5'-cyclic monophosphate Cyclic GMP

see Guanosine 3':5'-cyclic monophosphate 3': 5'-Cyclic nucleoside monophosphate phosphodiesterase


PhotoreceptorS, regulation of cyclic nucleotide concentrations: ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light, 3820

Cyclization equilibrium Moments of end-to-end vector of chain molecule, its persistence

and distribution, 1819 Cycloheximide


Cyclops scutifer (Sars) Setae of first antennae of copepod Cyclops scutifer (Sars):

structure and importance, 2656 Cystic fibrosis

Cystic fibrosis: fractionation of fibroblast media that inhibits ciliary activity, 548

Cytochalasin B Cytochalasin B: effect on lysosomal enzyme release from human

leukocytes, 844 Cytochalasin blocks sympathetic ganglionic transmission:

presynaptic effect antagonized by pyruvate, 1730 Preservation of normal behavior by enucleated cells in culture,

750 Cytochrome c

Cytochrome c, observation of numerous single-carbon sites of reduced and oxidized species by natural-abundance 13C nuclear magnetic resonance spectroscopy, 3531

Cytochrome c, separate intramolecular pathways for reduction and oxidation in electron transport chain reactions, 3245

Spin-state correlations in near infrared spectroscopy of cytochrome c', 1851

Cytochrome P-450 Cytochrome P-450 ligands, new method of study by linear electric

field-induced shifts in electron paramagnetic resonance, 2979 Polychlorinated biphenyls: new type of inducer of cytochrome

P-448 in the liver, 1321

Subject Index 13

Cytochrome P-700 Photosystem I chlorophyll-protein complex in greening leaves of

higher plants, biosynthesis of, 134 Cytochrome oxidase (EC 1.9.3.1)

Boundary lipid in membranes, 480 Cytochrome oxidase, electron carriers detectable by electron

paramagnetic resonance and their r-elationship to those traditionally recognized in this enzyme, 2477

Cytodestruction Human lymphotoxin, binding to target-cell membranes and its

relation to cell-mediated cytodestruction, 3082 Cytokinin

cis-Zeatin, isolation from Corynebacterium fascians cultures, 3825


Cytolysis Cytolysis of cultured lymphoma cells by adenosine 3' :5'-cyclic

monophosphate and isolation of resistant variants, 76 New complement-mediated cytolytic mechanism: Cl-bypass

activation pathway, 649 Cytoplasmic inheritance

Temperature-sensitive lethality in Nicotiana tabacum L., 108 Cytoplasmic segregation

Segregation during ascidian embryogenesis of egg cytoplasmic information for tissue-specific enzyme development, 2096

Cytosine see Antibody, cytosine-specific

Cytotoxicity Crossreactive antigens on human cells infected with Rauscher

leukemia virus and on human acute leukemia cells, 495 Simian virus 40 tumors, prevention by hamster fetal tissue:

influence of parity status of donor females on immunogenicity of fetal tissue and on immune cell cytotoxicity, 183

Daphnia Neuronal connections in isogenic organisms: optic system of

Daphnia magna, 57 Neuronal connections in isogenic organisms: cellular interactions

in development of optic lamina of Daphnia, 433 Dating, fossil

Racemization reaction of aspartic acid and its use in dating fossil bones, 1331

Deamidation Acceleration of rate of deamidatioh of GlyArgAsnArgGly and of

human transferrin by addition of l-ascorbic acid, 2122 Dedifferentiation


F-Deformation F-Deformations and F-tractions, 1634

Dehydrogenase Conformations of diphosphopyridine coenzymes upon binding to

dehydrogenases, 1593 Density measurement

Lipid bilayer phase transition: density measurements and theory, 3443

Deoxycytidine, 5-bromo- 5-Bromodeoxycytidine, phosphorylation in cells infected with

herpes simplex virus, 3788 Deoxycytidine monophosphate liydroxymethylase

Direct participation of dCMP hydroxymethylase in synthesis of bacteriophage T4 DNA, 2196

Deoxyglucose see Glucose transport

Deoxyribonuclease see also Enzyme, restriction Deoxyribonucleic acid, isolation of circular molecules from whole

cellular DNA by use of ATP-dependent deoxyribonuclease, 2884 Histones, blocking of accessibility to DNA in chromatin: addition

of histones (correction), 627 Deoxyribonucleic acid

Chromatin acidic proteins with high affinity for deoxyribonucleic acid: some binding parameters, 2524

HeLa cell deoxyribonucleic acid, breakdown mediated by vaccinia virus, 3200

Long pyrimidine polynucleotides, analysis in HeLa cell nuclear DNA: absence of polydeoxythymidylate, 2189

Non-Mendelian inheritance of DNA-induced inositol independence in Neurospora, 3875

Pyrimidine dimers, method for detecting in DNA of bacteria irradiated with low doses of ultraviolet light, 2753

Ribonucleic acid tumor virus-like DNA of primate is synthesized. endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood Cells, 3219

Deoxyribonucleic acid amplification Amplified ribosomal DNA release from chromomeres of Acheto,

80 Deoxyribonucleic acid, bacteriophage

Bacteriophage lambda heads, assembly in vitro, 260 3'-Terminal nucleotide sequences of bacteriophage X DNA, 1151

Deoxyribonucleic acid base pair Alteration of relative stability of dA-dT and dG-dC base pairs in

DNA, 298 Watson-Crick base pairs, nuclear magnetic resonance study of

hydrogen-bonded ring protons, 2899




Deoxyribonucleic acid base sequences Alignment of two DNA helices: model for recognition of DNA base

sequences by termini-generating enzymes of phage X, 186, and P2, 2667

Deoxyribonucleic acid-binding protein Cyclic adenosine monophosphate receptor: loss of

cAMP-dependent DNA binding activity after proteolysis in presence of cyclic adenosine monophosphate, 2529

Deoxyribonucleic acid-binding protein induced by bacteriophage T7, 1846

Deoxyribonucleic acid-binding protein induced by bacteriophage T7 (correction), 3007

Deoxyribonucleic acid, B-type Type-B DNA x-ray fiber diagrams, variation with base

composition, 2167 Deoxyribonucleic acid, C-form

Experimental differential light-scattering correction to circular dichroism of bacteriophage T2, 255

Sodium deoxyribonucleate, direct evidence for C-like form of, 3352

Deoxyribonucleic acid, chloroplast Hybridization of leucyl-transfer ribonucleic acid isoacceptors


Deoxyribonucleic acid, chromatin Deoxyribonucleic acid in chromatin, accessibility to DNA

polymerase and RNA polymerase, 1326 Deoxyribonucleic acid, circular

Bacteriophage X deoxyribonucleic acid, effect of circularity and superhelicity on transcription, 3077

Deoxyribonucleic acid, isolation of circular molecules from whole cellular DNA by use of ATP-dependent deoxyribonuclease, 2884

Ribonucleotides in mature closed-circular mitochondrial DNA, 3339

Self-complementarity of terminal sequences within plus or minus strands of adenovirus-associated virus DNA, 215

Deoxyribonucleic acid-deoxyribonucleic acid hybridization Repeated DNA sequences in heterochromatic Y chromosome of

adult Drosophila melanogaster, 773 Deoxyribonucleic acid-dependent ribonucleic acid polymerase

see Ribonucleic acid nucleotidyltransferase, deoxyribonucleic acid-dependent

Deoxyribonucleic acid, double- and single-stranded Infectious deoxyribonucleic acid from herpes simplex virus:

infectivity of double-stranded and single-stranded molecules, 3621

Deoxyribonucleic acid, double-stranded Deoxyribonucleic acid of mammalian cells, molecular nature in

alkaline sucrose gradients, 3660 Deoxyribonucleic acid helices


Deoxyribonucleic acid, inversion loop Genetic mapping of inversion loop in bacteriophage Mu DNA,

2153 Deoxyribonucleic acid magnification

Crossing-over between X and Y chromosomes during ribosomal DNA magnification in Drosophila melanogaster, 1950

Deoxyribonucleic acid, mercury ligand Stopped-flow apparatus with light-scattering detection and its

application to biochemical reactions, 890 Deoxyribonucleic acid methylase

Deoxyribonucleic acid methylase induced by bacteriophage qbX174, 3773

Deoxyribonucleic acid, mitochondrial Ribonucleotides in mature closed-circular mitochondrial DNA,

3339 Temperature-dependent formation of dimers and oligomers of

mitochondrial DNA in cells transformed by thermosensitive mutant of Rous sarcoma virus, 3739


Deoxyribonucleic acid, nuclear Deoxyribonucleic acid, unique nuclear sequences in involved

tissues of Hodgkin's and Burkitt's lymphomas, 3810 Hybridization of leucyl-transfer ribonucleic acid isoacceptors


Nuclear DNA sequences present in human leukemic cells and absent in normal leukocytes (correction), 627


Deoxyribonucleic acid nucleotidyltransferase Deoxyribonucleic acid in chromatin, accessibility to DNA

polymerase and RNA polymerase, 1326 Deoxyribonucleic acid polymerase from Bacillus subtilis,

inhibition by hydroxyphenylazopyrimidines, 103 Deoxyribonucleic acid polymerase activity, survey during early

development of Drosophila melanogaster, 2946 Histones, addition to histone-depleted nuclei: effect on template

activity toward DNA and RNA polymerases, 2637 Hydroxyphenylazopyrimidines: characterization of active forms

and their inhibitory action on DNA polymerase from Bacillus subtilis, 512

Mutagenic DNA polymerase in human leukemic cells, 245 Poxviruses, biogenesis of: inactivation of host DNA polymerase

by component of invading inoculum particle, 1726 Primer requirement and template specificity of DNA polymerase

of chick embryo, 1229 Selective extraction of histones, effects on template activities of

chromatin by use of exogenous DNA and RNA polymerases, 1973

Terminal deoxynucleotidyltransferase in childhood acute lymphoblastic leukemia, 521

Viral DNA polymerase in mouse milk: characterization and separation, 2117

Deoxyribonucleic acid nucleotidyltransferase (EC 2.7.7.7) Reverse transcription by Escherichia coli DNA polymerase I,

3834 Deoxyribonucleic acid nucleotidyltransferase I

Deoxyribonucleic acid polymerase I primed by synthetic oligonucleotide used to determine nucleotide sequence in phage fl DNA, 1209

Ultraviolet-stimulated DNA synthesis in toluenized Escherichia coli deficient in DNA polymerase I, 129

Deoxyribonucleic acid nucleotidyltransferase III* Deoxyribonucleic acid polymerase III star requires ATP to start

synthesis on primed DNA, 3679 New DNA polymerase from human breast tumor cell line HBT-3,

detection and isolation by (dT) 12-l8-cellulose chromatography, 2453

New form of DNA polymerase III and copolymerase replicate long, single-stranded primer-template, 1764

Deoxyribonucleic acid nucleotidyltransferase, copolymerase for New form of DNA polymerase III and copolymerase replicate

long, single-stranded primer-template, 1764 Deoxyribonucleic acid of Epstein-Barr virus


Linear association between cellular DNA and Epstein-Barr virus DNA in human lymphoblastoid cell line, 2888

Deoxyribonucleic acid polymerase see Deoxyribonucleic acid nucleotidyltransferase

Deoxyribonucleic acid, primed Deoxyribonucleic acid polymerase III star requires ATP to start

synthesis on primed DNA, 3679 Deoxyribonucleic acid repair

Deficient DNA repair in human progeroid cells, 977 Deoxyribonucleic acid repair that contains interstrand crosslinks

in Escherichia coli: sequential excision and recombination, 1064 Deoxyribonucleic acid replication

Bacteriophage 186 DNA, origin and direction of replication, 1768 Deoxyribonucleic acid polymerase from Bacillus subtilis,

inhibition by hydroxyphenylazopyrimidines, 103 Deoxyribonucleic acid replication in mammalian chromosomes:

isolation of replicating segments, 1083 Deoxyribonucleic acid replication, microfluorometric detection in

human metaphase chromosomes, 3395 Direct participation of dCMP hydroxymethylase in synthesis of

bacteriophage T4 DNA, 2196 Do cells cycle? 1263 Independent control of ribosomal gene replication in polytene

chromosomes of Drosophila melanogaster, 1359 Initiation and continuation of DNA replication are not associated

with nuclear envelope in mammalian cells, 714 Isolation of dnaB gene product from Escherichia coli, 3120 Nalidixic acid, effect on DNA replication by toluene-treated

Escherichia coli, 1955 Replication and transcription relationship of simian virus 40

DNA, 1927 Ribonucleic acid-linked short DNA fragments during polyoma

replication, 412 Ribosomal RNA genes, amplification involves rolling circle

intermediate, 2926 Deoxyribonucleic acid, rolling circle intermediate

Ribosomal RNA genes, amplification involves rolling circle intermediate, 2926

Deoxyribonucleic acid, satellite Cesium sulfate gradients that contain both Hg2+ and Ag+ effect

complete separation of satellite deoxyribonucleic acids having identical densities in neutral cesium chloride gradients, 3108

Drosophila virilis, family of three related satellite DNAs, 2772 5-Hydroxymethyluracil in DNA of dinoflagellate, 1141 Nucleotide sequence of HS-3 satellite DNA from kangaroo rat

Dipodomys ordii, 2642 Relatedness of mouse satellite deoxyribonucleic acid to

deoxyribonucleic acid of various Mus species, 3546 Deoxyribonucleic acid sequence

Adenovirus type 2 DNA cleavage into six unique fragments by endonuclease R-RI, 200

Drosophila genome, proposal for structure of, 535 Leukemia-specific DNA sequences in leukocytes of leukemic

member of identical twins, 2629 Nonrepetitive deoxyribonucleic acid sequence representation in

sea urchin embryo messenger RNA, 3516 Repeated DNA sequences in heterochromatic Y chromosome of

adult Drosophila melanogaster, 773 Ribonucleic acid polymerase binding sites of Escherichia coli,


Simian virus 40 sequences, in vitro transcription in SV3T3 chromatin, 2304

Deoxyribonucleic acid specificity Ribonucleic acid-dependent deoxyribonucleic acid polymerase in

type C viruses, specificity of DNA product II: quantitative analysis, 3923

14 Subject Index




Deoxyribonucleic acid structure Type-B DNA x-ray fiber diagrams, variation with base

composition, 2167 Deoxyribonucleic acid, supercoiled

Ribonucleic acid, size and base composition in supercoiled plasmid DNA, 3744

Deoxyribonucleic acid, superhelicity Bacteriophage A deoxyribonucleic acid, effect of circularity and

superhelicity on transcription, 3077 Deoxyribonucleic acid synthesis

Chromosome replication during meiosis: identification of gene functions required for premeiotic DNA synthesis, 3087

Deoxyribonucleic acid synthesis in vitro: purification of dnaG gene product from Escherichia coli, 1613

Deoxyribonucleic acid synthesis in vitro: purification of dnaC gene product containing dnaD activity from Escherichia coli, 2369

Deoxyribonucleic acid synthesis, suppression in hepatoma cells exposed to glucocorticoid ,hormone in vitro, 3852

Enzymatic synthesis of DNA complementary to purified 14S messenger RNA of immunoglobulin light chain, 693

Poly(inosinic acid).poly(cytidylic acid) inhibition of DNA synthesis in synchronized HeLa cells, 3904

Synthesis of [3H]DNA complementary to ovalbumin messenger RNA: evidence for limited copies of ovalbumin gene in chick oviduct, 3776

Thymocytes from NZB mice of different ages, alteration in DNA synthetic response, 3769

Deoxyribonucleic acid synthesis, discontinuous Ribonucleic acid-linked short DNA fragments during polyoma

replication, 412 Deoxyribonucleic acid synthesis, prokaryotic

Ribonucleic acid-linked DNA fragments in vitro, 88 Ribonucleic acid-linked DNA fragments in vitro (correction), 1284 Ultraviolet-stimulated DNA synthesis in toluenized Escherichia

coli deficient in DNA polymerase I, i29 Deoxyribonucleic acid synthesis, vital

Coat protein of bacteriophage M 13 virion participates in membrane-oriented synthesis of DNA, 205


Sequence of spontaneous Epstein-Barr virus activation and selective DNA synthesis in activated cells in presence of hydroxyurea (correction), 284

Deoxyribonucleic acid template activity Selective extraction of histones, effects on template activities of


Deoxyribonucleic acid transcription Adjacent transfer RNA genes in Escherichia coli, 438 Globin ribonucleic acid, synthesis from duck-reticulocyte

chromatin in vitro, 2029 Mitochondria, autonomy of, in Saccharomyces cerevisiae in

production of messenger RNA, 111 Mutant transcription factor that is activated by 3' :5'-cyclic

guanosine monophosphate, 1017 Replication and transcription relationship of simian virus 40

DNA, 1927 Repression of transcription of gal operon by purified gal

repressor in vitro, 334 Repression of transcription of tryptophan operon by trp repressor

in vitro, 1990 Ribonucleic acid, initiation of, with dinucleoside monophosphates

during transcription of bacteriophage T4 DNA with RNA polymerase of Escherichia coli, 574

T7 early RNAs are generated by site-specific cleavages, 1559 Transcription of rat-liver chromatin with homologous enzyme,

1161 Deoxyribonucleic acid, transforming

Separation of specific segments of transforming DNA after treatment with endodeoxyribonuclease, 503

Deoxyribonucleic acid tumor virus Nonvirion antigens produced by herpes simplex Viruses 1 and 2,

1032 Deoxyuridinie, 5-bromo-

Bromodeoxyuridine dependence: new mutation in mammalian cells, 138

5-Bromo-2'-deoxyuridine, effects on production of globin messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells, 2956

5-Bromo-2'-deoxyuridine potentiation of transformation of rat-embryo cells induced in vitro by 3-methylcholanthrene: induction of rat leukemia virus gs antigen in transformed cells, 2415

Chondrogenesis in limb-bud cell cultures, control with bromodeoxyuridine, 2201

Sequence of spontaneous Epstein-Barr virus activation and selective DNA synthesis in activated cells in presence of hydroxyurea (correction), 284

Deoxyuridine, 5-iodo-2' Adrenal corticosteroids enhance production of type-C virus

induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblastS, 2391

Dermatosparaxis Cell-free synthesis of procollagen: L-929 fibroblasts as cellular

model for dermatosparaxis, 1378 Detergent

Detergent hydrophobic lipophilic balance (HLB) number, relation to solubilization and stabilization of D-alanine carboxypeptidase

Subject Index 15

from Bacillus subtilis membranes, 2997 Deuterium oxide

Differential effect of heavy water on temperature-dependent and temperature-compensated aspects of circadian system of Drosophila pseudoobscura, 2037

Dextran Immunochemical analysis of cross-reacting idiotypes of mouse


3,6-Diaminoacridine Cell-surface interactions: differential inhibition by proflavine of


Diazoacetyl subtilisin Diazoacetyl subtilisin, 1132

Dibenzpyrene Stimulation of host defense system by coenzyme Qlo, effect on

dibenzpyrene-induced tumors and infection with Friend leukemia virus in mice, 390

Dictyostelium discoideum 5'-Adenosine monophosphate-dependent adenylate cyclase and


Cell contact model for cellular position determination in development, 2396

Dictyostelium discoideum, developmentally regulated, carbohydrate-binding protein in, 2554


Light-induced absorbance changes associated with phototaxis in Dictyostelium, 813

Mating types and macrocyst formation in Dictyostelium discoideum, 1828

Membrane sites in aggregating Dictyostelium cells, quantitation by use of tritiated univalent antibody, 3150

Mutations affecting N-acetylglucosaminidase in Dictyostelium discoideum, 3356

Dictyostelium purpureum Genetic analysis of developmental stages of cellular slime mold

Dictyostelium purpureum, 2003 Diethyistilbestrol

see Estrogen Differential light-scattering

Experimental differential light-scattering correction to circular dichroism of bacteriophage T2, 255

Differentiation see also Dedifferentiation lBone morphogenesis in implants of insoluble bone gelatin, 3511 Cell contact model for cellular position determination in

development, 2396 Chondrogenesis in limb-bud cell cultures, control with

bromodeoxyuridine, 2201 Control of normal differentiation of rnyeloid leukemic cells to

macrophages and granulocytes, 343 Differentiated functions in hepatoma cell hybrids: expression of

alanine aminotransferase, 377 Differentiation in Nostoc muscorum: nitrogenase is synthesized in

heterocysts, 2727 Differentiation of lens tissue from progeny of chick retinal

pigment cells cultured in vitro: demonstration of switch of cell .types in clonal cell culture; 1495

Early differentiation of glucagon-producing cellt in embryonic pancreas: possible developmental role for glucagon, 3478

Lambda-chain production in human lymphoblast-mouse fibroblast hybrids, 2401

Mobility of carbohydrate-containing structures on surface membrane and normal differentiation of myeloid leukemic cells to macrophages and granulocytes, 2577


Surface antigens common to mouse cieavage embryos and primitive teratocarcinoma cells in culture (correction), 3932

Synaptic differentiation in regenerating crab-limb muscle, 822 Temperature-sensitive variants of established myoblast line, 425 Tobacco pith cells, habituation for factors promoting cell division

is heritable and potentially reversible, 2660 Differentiation, terminal

Programming of cells for death under defined experimental conditions: relevance to tumor problem, 3055

Diffusion control Polarographic catalytic waves observed with bovine-serum


albumin: kinetic or diffusion control (correction), 2710 1,25-Dihydroxycholecalciferol

la-Hydroxycholecalciferoi, synthetic analog of hormonal form of vitamin D3: biological activity, 2248

L-Dihydroxyphenylalinine decarboxylase (EC 4.1.1.26) Cycloheximide and acetoxycycloheximide: inhibition of tyrosine

hydroxylase activity and amnestic effects, 354 7,12-Dimethylbenz (a) anthracene


Dimethylsuberimidate Ribosomes crosslinked with dimethylsuberimidate: structural and

functional properties (correction), 1618 Dimethyl sulfoxide

5-Bromo-2'-deoxyuridine, effects on production of globin




messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells, 2956

Dinoflagellate see Gyrodinium cohnii

Dinucleoside monophosphate Crystalline fragment of double helix: structure of dinucleoside

phosphate guanylyl-3',5'-cytidine, 849 Ribonucleic acid, initiation of, with dinucleoside monophosphates


o-Diphenol oxidase (EC 1.10.3.1) Segregation during ascidian embryogenesis of egg cytoplasmic

information for tissue-specific enzyme development, 2096 Diphosphopyridine nucleotide

see Nicotinamide adenine dinucleotide Diplococcus pneumoniae

Marker discrimination in transformation and mutation of pneumococcus, 3541

Diploidization Genetic system in parthenogenetic strains of Drosophila

mercatorum, 1772 Dipodomys ordii

Nucleotide sequence of HS-3 satellite DNA from kangaroo rat Dipodomys ordii, 2642

Distribution Robust confidence interval for location for symmetric, long-tailed

distributions, 1995 Disulfide bond

Collagen synthesis: disulfide-linked collagen precursor in chick bone, 2993

Disulfide bond dihedral angles from Raman spectroscopy, 2619 Disulfide-linked procollagen, identification as biosynthetic

precursor of chick-bone collagen, 3521 Production of noncovalently bonded pentamer of immunoglobulin

M: relationship to J-chain, 3410 Dithionite

Reduction of ferricytochrome c by dithionite ion: electron transfer by parallel adjacent and remote pathways, 1701

dnaB gene Isolation of dnaB gene product from Escherichia coli, 3120

dnlaC gene Deoxyribonucleic acid synthesis in vitro: purification of dnaC

gene product containing dnaD activity from Escherichia coli, 2369

dnaD gene Deoxyribonucleic acid synthesis in vitro: purification of dnaC

gene product containing dnaD activity from Escherichia coli, 2369

dnaE gene Bacteriophage XX-174, replication in mutant of Escherichia coli

defective in dnaE gene, 1757 dnaE mutant of Escherichia coli

New form of DNA polymerase III and copolymerase replicate long, single-stranded primer-template, 1764

dnaG gene product Deoxyribonucleic acid synthesis in vitro: purification of dlaG

gene product from Escherichia coli, 1613 DNase

see Deoxyribonuclease Dogfish

see Squalus acanthius Dopamine hydroxylase (EC 1.14.2.1)

Dopamine-3-hydroxylase: tetrameric glycoprotein, 2253 Drosophila

see also Mutant of Drosophila Chromosomal control of mating activity in Drosophila

pseudoobscura, 459 Crossing-over between X and Y chromosomes during ribosomal

DNA magnification in Drosophila melanogaster, 1950 Deoxyribonucleic acid polymerase activity, survey during early

development of Drosophila melanogaster, 2946 Differential effect of heavy water on temperature-dependent and

temperature-compensated aspects of circadian system of Drosophila pseudoobscura, 2037

Drosophila genome, proposal for structure of, 535 Drosophilo virilis, family of three related satellite DNAs, 2772 Genetic system in parthenogenetic strains of Drosophila

mercatorum, 1772 Genetic variability in natural populations, 3928 Independent control of ribosomal gene replication in polytene

chromosomes of Drosophila melanogaster, 1359 Neurophysiology of flight in wild-type and mutant of Drosophila,

1050 Relative orientation with respect to centromere of ribosomal RNA


Repeated DNA sequences in heterochromatic Y chromosome of adult Drosophila melanogaster, 773



Drug see specific drugs

Drug-resistant variants of cell Drug-resistant variants of mammalian tissue culture cells,

altered enzymes, 3145

Ductus deferens Calcium ions, importance for regulation of guanosine 3':5'-cyclic

monophosphate levels, 3889 Guanosine 3':5'-cyclic monophosphate, new enzymatic assay and

its application to ductus deferens of rat, 1721 Dysbetalipoproteinemia

see Primary dysbetalipoproteinemia Dysgenic subpopulation

Confirmation of Negro economic gains on whites and identification of dysgenic subpopulations by "offset analysis" (abstract), 3935

Earth Is the inner core liquid after all? (abstract), 2178

Earth history Biological versatility and earth history, 1936

Earth's atmosphere Heliomagnetic-geomagnetic modulation of radiocarbon production

in earth's atmosphere (abstract), 2178 Earth's radii

Seismological inverse problem: informative solution, 1410 Ecology

Sodium dynamics in northern ecosystem, 2745 Economics

see also Marxian economics Optimality of profit-including prices under ideal planning, 2109

Ecosystem, northern Sodium dynamics in northern ecosystem, 2745

Eel see Electrophorus

Egg cytoplasm Segregation during ascidian embryogenesis of egg cytoplasmic

information for tissue-specific enzyme development, 2096 Egg, sea urchin

In vitro translation of oogenetic messenger RNA of sea urchin eggs and picornavirus RNA with cell-free system from sarcoma 180, 3287

Ehrlich ascites cell see Ascites cell, Ehrlich

Elastic deformation Rubbery materials, new elastic potential function, 3041

Electrical potential Electrical potential, role in coupling of metabolic energy to active

transport by membrane vesicles of Escherichia coli, 1804 Electrical rectification

Ion-diffusion potentials and electrical rectification across lipid membranes activated by excitation-induced material (correction), 1284

Electric eel see Electrophorus

Electric organ membrane Sodium-selective ionophoric material from electric organ and

kidney membranes, 1191 Electric tissue


Electrode, membrane Equilibrium potentials of membrane electrodes, 1909

Electrolyte Fluctuation spectroscopy: determination of chemical reaction

kinetics from frequency spectrum of fluctuations, 870 Electron

Amines, interaction with ketone aldehydes and unsaturated aldehydes, 1030

Electron carriers Cytochrome oxidase, electron carriers detectable by electron

paramagnetic resonance and their relationship to those traditionally recognized in this enzyme, 2477

Electron density map Carboxypeptidase A's, enzymatic activities in solution and in

crystals, 3797 Structure of hemoglobin M Boston, variant with five-coordinated

ferric heme, 3870 Electron-exchange interaction

Triplet-triplet energy transfer in a-trypsin, 3703 Electronic effect


Electron microscopy see also Immunoelectronmicroscopy Acetylcholinesterase from electric organ tissue of electric eel:

molecular structures, 2473 Deoxyribonucleic acid of mammalian cells, molecular nature in

alkaline sucrose gradients, 3660 Membrane structure, changes associated with cell contact, 3631 Structure of sickled erythrocytes and of sickle-cell hemoglobin

fibers, 718 Ultrastructure of ferritin macromolecules: lattice structure of

core crystallites, 3847 Electron microscopy, scanning

Scanning transmission electron microscope studies of deep-frozen unfixed muscle correlated with spatial localization of intracellular elements by fluorescent x-ray analysis, 3423


Wet chemical method for rendering scanning electron microscopy samples conductive and observations on surface morphology of




human erythrocytes and Ehrlich ascites cells, 3599 Electron paramagnetic resonance

Amines, interaction with ketone aldehydes and unsaturated aldehydes, 1030

Cytochrome oxidase, electron carriers detectable by electron paramagnetic resonance and their relationship to those traditionally recognized in this enzyme, 2477

Cytochrome P-450 ligands, new method of study by linear electric field-induced shifts in electron paramagnetic resonance, 2979

Electron spin resonance studies of spin-labeled mammalian cells by detection of surface membrane signals, 66

Electron transfer Electron paramagnetic resonance of nitrogenase and nitrogenase


Free radical detection in primary reaction of chloroplast photosystem II, 294

Molecular mechanism for action of molybdenum in enzymes: coupled proton and electron transfer, 988


Electron transport Anaerobic transport in Escherichia coli membrane vesicles, 3376 Cytochrome c, separate intramolecular pathways for reduction

and oxidation in electron transport chain reactions, 3245 Electron transport-linked compared with proton-induced ATP

generation in Thiobacillus novellus, 3571 Enzyme assay in microsomes below zero degrees, 2633 Hydrogen evolution by chloroplast-ferredoxin-hydrogenase

system, 2317 Electrophoresis

see Polyacrylamide gel electrophoresis, two-dimensional Electrophorus

Acetylcholinesterase from electric organ tissue of electric eel: molecular structures, 2473



Sodium-selective ionophoric material from electric organ and kidney membranes, 1191

Elongation see Cell elongation

Elongation factor Conformational control of interaction of eukaryotic elongation

factors EF-1 and EF-2 with ribosomes, 3556 Elongation factor 1, multiple forms from calf brain, 3282 Guanine nucleotides and elongation factors, influence on

interaction of release factors with ribosome, 2350 Ribosome dissociation factor from rabbit reticulocytes distinct

from initiation factor M3, 2220 Elongation factor G

Elongation factor G, interaction with N-acetylphenylalanyl transfer RNA-ribosome complexes, 3561

Guanine nucleotides, role in protein synthesis: elongation factor G and guanosine 5'-triphosphate,3'-diphosphate, 3250

Proteins S5 and S9 from 30S subunits, requirement for ribosome-dependent GTPase activity of elongation factor G, 151

Ribosomal proteins involved in interaction with elongation factor G, 147

Embryo, amphibian Microinjection of rabbit hemoglobin messenger RNA into

amphibian oocytes and embryos, 543 Embryo, avian

Auditory neuronal responses, development in avian embryos, 1795

Embryo, chick Cell-surface interactions: differential inhibition by proflavine of



Endogenous RNA-dependent DNA polymerase activity in uninfected chicken embryos (correction), 284

Glutamine synthetase induction in embryonic neural retina: immunochemical identification of polysomes involved in enzyme synthesis, 1667

Plasma membranes, specific recognition by embryonic cells, 2794 Snake a-neurotoxin, effects on development of innervated skeletal

muscles in chick embryo, 1708 Embryogenesis, ascidian

Segregation during ascidian embryogenesis of egg cytoplasmic information for tissue-specific enzyme development, 2096

Embryo, mouse Cell-surface glycoproteins of mouse embryos: change before

implantation, 1645 Surface antigens common to mouse cleavage embryos and

primitive teratocarcinoma cells in culture, 2988 Surface antigens common to mouse cleavage embryos and

primitive teratocarcinoma cells in culture (correction), 3932 Embryo, sea urchin

Nonrepetitive deoxyribonucleic acid sequence representation in sea urchin embryo messenger RNA, 3516

Encephalitis see Subacute sclerosing panencephalitis

Encephalomyocarditis virus Double-stranded RNA as inhibitor of protein synthesis and as

substrate for nuclease in extracts of Krebs II ascites cells, 225

Subject Index 17

Encephalopathy Tropism of Mycoplasma gallisepticum for arterial walls, 1545

Endodeoxyribonuclease see Enzyme, restriction

Endonuclease see Enzyme, restriction

Endoperoxide intermediate Endoperoxide intermediate in prostaglandin biosynthesis:

detection and isolation, 899 Endoribonuclease

Colicin E3: unique endoribonuclease, 156 Endothelial swelling


Endotoxin Endotoxin potentiates responses associated with increases in

calcium conductance, 3301 Energy

see Solar energy conversion Energy coupling

Different mechanisms of energy coupling for active transport of proline and glutamine in Escherichia coli, 1514

Oxidative phosphorylation, concept for energy coupling based on molecular explanation of oxygen exchange reactions, 2837

Energy of activation Temperature adaptation of enzymes: roles of free energy,

enthalpy, and entropy of activation, 430 Temperature-sensitive change in energy of activation of

hormone-stimulated hepatic adenylyl cyclase, 1785 Enthalpy of activation

Temperature adaptation of enzymes: roles of free energy, enthalpy, and entropy of activation, 430

Entropy of activation Temperature adaptation of enzymes: roles of free energy,

enthalpy, and entropy of activation, 430 Enzyme

see also Lysosomal enzyme; specific enzymes Enzyme activity

Carboxypeptidase A's, enzymatic activities in solution and in crystals, 3797

Enzyme assay Enzyme assay in microsomes below zero degrees, 2633 Phenylethanolamine in brain and other tissues: demonstration

and distribution, 769 Enzyme, ectothermic

Temperature adaptation of enzymes: roles of free energy, enthalpy, and entropy of activation, 430

Enzyme induction Allantoin degradative enzymes, induction in Saccharomyces

cerevisiae by last intermediate of pathway, 2340 Autoregulation: role for biosynthetic enzyme in control of gene

expression, 2757 Human regulatory gene for inducible tyrosine aminotransferase

in rat-human hybrids, 1268 Polychlorinated biphenyls: new type of inducer of cytochrome

P-448 in the liver, 1321 Enzyme loading

Enzyme loading of erythrocytes, 2663 Enzyme mechanism

Catalytic mechanism of carbonic anhydrase, 2505 Tyrosyl residue, role in mechanism of action of carboxypeptidase

B: luminescence studies, 2025 Enzyme polymorphism



Enzyme regulation 5'-Adenosine monophosphate-dependent adenylate cyclase and


Enzyme, restriction Adenovirus type 2 DNA cleavage into six unique fragments by

endonuclease R.RI, 200 Separation of specific segments of transforming DNA after

treatment with endodeoxyribonuclease, 503 Transcription of simian virus 40: mapping of "early" and "late"

species of RNA, 3711 Enzyme subunit

Glutaminase activity of glutamine amidotransferase (carbamylphosphate synthetase), pH dependence, 2717

Thermophilic aminopeptidase I, function of two subunits, 3781 Enzyme synthesis

Differentiation in Nostoc muscorum: nitrogenase is synthesized in heterocysts, 2727

Messenger RNA for hepatic tryptophan oxygenase: partial purification, translation in heterologous cell-free system, and control by glucocorticoid hormones, 1218

Epidermal growth factor Epidermal growth factor: receptors in human fibroblasts and

modulation of action by cholera toxin, 2964 Epigenesis

Neuronal networks, theory of epigenesis by selective stabilization of synapses, 2974

Epinephrine Temperature-sensitive change in energy of activation of

hormone-stimulated hepatic adenylyl cyclase, 1785




Epistasis Adaptive linkage disequilibrium between two esterase loci of

salamander, 1156 Epithelial cell, iris


Epstein-Barr virus see also Deoxyribonucleic acid of Epstein-Barr virus Burkitt's tumors contain particles encapsulating RNA-instructed



Infectious Epstein-Barr virus release by transformed marmoset leukocytes, 190

Linear association between cellular DNA and Epstein-Barr virus DNA in human lymphoblastoid cell line, 2888

Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus, 2487

Malignant lymphomas of African children, 15 Sequence of spontaneous Epstein-Barr virus activation and

selective DNA synthesis in activated cells in presence of hydroxyurea (correction), 284

Equilibrium potential Equilibrium potentials of membrane electrodes, 1909

Equivalence relation Stereochemical correspondence among chemically disparate

systems: spirocyclic phosphoranes, diarylmethanes, and cognates, 3445

Ergodic transformations Maximal functions and HP spaces defined by ergodic

transformations, 1761 Erythroblast

Globin messenger sequences in giant nuclear precursors of messenger RNA of avian erythroblasts, 1122

Erythrocyte Adenosine 3' :5'-cyclic monophosphate-dependent protein kinase,

studies on orientation in human erythrocyte membranes, 3735 Adenosine 3':5'-cyclic monophosphate receptor, specific



Aspirin, effect on sickling and oxygen affinity of erythrocytes, 3707

Cell-free translation of globin message within polydisperse high-molecular-weight ribonucleic acid of avian erythrocytes, 3641

Enzyme loading of erythrocytes, 2663 Erythrocyte ghost ultrastructure, preservation achieved by

various fixatives, 3060 Erythrocytes, normal production by mouse marrow for 73

months, 3184 Hemoglobin S, structure and optical determination of molecular

orientation in sickled erythrocytes, 3604 Human sickle-cell erythrocytes, survival in heterologous species:

response to variations in oxygen tension, 2356 Membrane intercalated particles in human erythrocyte ghosts:

sites of preferred passage of water molecules at low temperature, 1339

Nicotinamide-adenine dinucleotide phosphate glycohydrolase deficiency in human erythrocytes and alteration of cytosol NADH-methemoglobin diaphorase by membrane NAD-glycohydrolase activity, 2406

Protein kinase activity in erythrocyte ghosts of patients with myotonic muscular dystrophy, 1855

Structure of sickled erythrocytes and of sickle-cell hemoglobin fibers, 718


Erythromycin Altered chloroplast ribosomal proteins associated with


Erythropoietin Hemoglobin switching in sheep and goats:

erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures, 1739

Ribonucleic acid synthesis, early stimulation by erythropoietin in cultures of erythroid precursor cells, 3189

Escherichia coli see also Mutant of Escherichia coli; Ribosome, Escherichia coli Adjacent transfer RNA genes in Escherichia coli, 438 Anaerobic transport in Escherichia coli membrane vesicles, 3376 Aspartate transcarbamoylase from Escherichia coli: electron

density at 5.5 angstrom resolution, 1117 Chloramphenicol-binding protein, identification in Escherichia

coli ribosomes by partial reconstitution, 2224 Chloramphenicol-binding protein, identification in Escherichia

coli ribosomes by affinity labeling, 2229 Deoxyribonucleic acid repair that contains interstrand crosslinks

in Escherichia coli: sequential excision and recombination, 1064 Deoxyribonucleic acid synthesis in vitro: purification of donaG

gene product from Escherichia coli, 1613 Different mechanisms of energy coupling for active transport of

proline and glutamine in Escherichia coli, 1514 Electrical potential, role in coupling of metabolic energy to active

transport by membrane vesicles of Escherichia coli, 1804 Evolution of second gene for ,f-galactosidase in Escherichia coli,

1841 Functional correspondence between 30S ribosomal proteins of

Escherichia coli and Bacillus stearothermophilus, 944 Isolation of dnaB gene product from Escherichia coli, 3120 Lipopolysaccharide protein, isolation and characterization from

Escherichia coli, 2572 Mapping of Escherichia coli ribosomal components involved in

peptidyl transferase activity, 1423 Metabolism of membrane phospholipids and its relation to novel

class of oligosaccharides in Escherichia coli, 1368 Mutant of Escherichia coli with new, highly efficient promoter for

lactose operon, 3693 Mutants of Escherichia coli thermosensitive for synthesis of

transfer RNA, 2091 Nonribosomal synthesis of guanosine 5',3'-polyphosphates by

ribosomal wash of stringent Escherichia coli, 2145 Nucleotide modification in vitro of precursor of transfer RNAFryr

of Escherichia coli, 3626 Nucleotide modification in vitro of precursor of transfer RNA'Yr

of Escherichia coli (correction), 3932 Nucleotide sequence divergence in a-chain-structural genes of


Nucleotide sequence of lactose messenger ribonucleic acid transcribed from UV5 promotor mutant of Escherichia coli, 3585

Polypeptide-chain initiation, specific inhibitor in Escherichia coli, 2874

Polysomal ribosomes of Escherichia coli, partial inhibition by streptomycin, 1234

Protein involved in peptidyltransferase activity of Escherichia coli ribosomes, 1931

Purine polyribonucleotide synthetase from Escherichia coli, 2558 Recircularization and autonomous replication of sheared R-factor

DNA segment in Escherichia coli transformants, 1293 Reconsititution of D-lactate-dependent transport in membrane

vesicles from D-lactate dehydrogenase mutant of Escherichia coli, 1917

Reverse transcription by Escherichia coli DNA polymerase I, 3834


Ribonucleic acid polymerase binding sites of Escherichia coli, isolation on T5 and T7 DNA: further evidence for sigma-dependent recognition of A-T rich DNA sequences, 2911

Ribonucleic acid polymerase of Escherichia coli, regulation of subunit synthesis, 2651

Ribonucleic acid synthesis, stimulating substances isolated from red kidney bean: their activities in lymphocytes and Escherichia coli, 569

Ribosomal protein S4 alteration by mutation linked to kasugamycin-resistance in Escherichia coli, 71

50S proteins, identification at peptidyl-tRNA binding site of Escherichia coli ribosomes, 2799

Stable RNA synthesis in stringent Escherichia coli cells in absence of charged transfer RNA, 689

Synthesis of large precursor to ribosomal RNA in mutant of Escherichia coli, 3361

T7 early ribonucleic acids and Escherichia coli ribosomal RNAs are cut from large precursor RNAs in vivo by ribonuclease III, 3296



Escherichia coli B Measurements of rates of adenosine 3':5'-cyclic monophosphate

synthesis in intact Escherichia coli B, 2149 Ribonucleic acid polymerase, modification after T3 phage

infection of Escherichia coli B, 2845 Escherichia coli K12

Cell envelope and shape of Escherichia coli K12, 2033 Colicin K of Escherichia coli K235, 854 Genetic transformation in Escherichia coli K12, 84

Escherichia coli, toluene-treated Nalidixic acid, effect on DNA replication by toluene-treated

Escherichia coli, 1955 Esterase locus

Adaptive linkage disequilibrium between two esterase loci of salamander, 1156

17f-Estradiol Translational control of specific uterine protein synthesis after

estrogen induction, 18 Estrogen

Induction rates of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones, 1870

Nuclear binding of steroid receptors: comparison in intact cells and cell-free systems, 3415


Ethane, substituted Energy of substituted ethanes: asymmetry orbitals, 531

Ethidium bromide Population analysis of deinduction kinetics of galactose long-term

adaptation mutants of yeast, 919




Ethyl alcohol Light-induced phase shifts of circadian leaf movements of

Phaseolus: comparison with effects of potassium and of ethyl alcohol, 3387

Ethylene Ethylene in plant growth (N.A.S. Symposium: plant growth

regulation), 591 Etorphine

Stereospecific binding of potent narcotic analgesic [3H]etorphine to rat-brain homogenate, 1947

Euglena Cytoplasmic regulatory mutant of Euglena: constitutivity for

light-inducible chloroplast transfer RNAs, 1749 Eukaryotic cell

see Cell, eukaryotic European Organization for Nuclear Research


Euthynnus lineatus Heat exchange in black skipjack, and blood-gas relationship of

warm-bodied fishes, 1964 Evolution

Alcohol dehydrogenase of yeast and liver: partial similarities, 2295

ac- and 3-Tublin, isolation and partial characterization from outer doublets of sea-urchin sperm and microtubules of chick-embryo brain, 3594

Biological versatility and earth history, 1936 D-Glyceraldehyde-3-phosphate dehydrogenase: three-dimensional

structure and evolutionary significance, 3052 Ecological theory for sudden origin of multicellular life in late

Precambrian, 1486 Evolution of second gene for ,-galactosidase in Escherichia coli,

1841 Frequency-dependent natural selection model for evolution of

social cooperation networks, 187 Genetic system in parthenogenetic strains of Drosophila

mercatorum, 1772 Genetic variability in natural populations, 3928 Nucleotide sequence divergence in a(-chain-structural genes of


Relatedness among contractile and membrane proteins: evidence for evolution from common ancestral genes, 3230

Relatedness of mouse satellite deoxyribonucleic acid to deoxyribonucleic acid of various Mus species, 3546

Sequence homologies among bacterial and mitochondrial superoxide dismutases, 3725

Excitation unit see Nerve, basic excitation unit of

5'-Exonuclease Phage-induced 5'-exonuclease, requirement for expression of late

genes of bacteriophage T5, 3502 Exosome


Exponents, arbitrary p-Algebras of arbitrary exponents, 533

Extraction, selective Selective extraction of histones, effects on template activities of


Extranuclear mutant Virus-like particles in extranuclear mutant of Neurospora crassa,

1574 Eye


Eye, compound lateral Inhibition, facilitation of, in compound lateral eye of Limulus, 894

Eyespot disease Biochemical basis of resistance of sugarcane to eyespot disease,

1693

Fab' fragment Fab' fragment, three dimensional structure of human

immunoglobulin at 2.8 angstrom resolution, 3305 Factor

see also Elongation factor; Initiation factor; Nerve growth factor Factor VII

Membrane lipoprotein activation of proteolytic system: mechanism of action of tissue factor, 310

Factor VIII Factor VIII recombination after dissociation by CaC12, 2326 Plasma aggregating factor (bovine) for human platelets: marker

for study of antihemophilic and von Willebrand factors, 2814 Familial hypercholesterolemia

Familial hypercholesterolemia: identification of defect in regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol, 2804

Fasting Changes in rabbit-liver lysosomes and fructose

1,6-bisphosphatase induced by cold and fasting, 3674 Fat cell

see Cell, fat Fat cell ghost

Affinity binding of intact fat cells and their ghosts to immobilized

Subject Index 19

insulin, 792 Fatty acid

see also Lipid; specific fatty acids Amphiphilic spin labels, orientation and motion in hexagonal lipid

phases, 1406 Growth inhibition and morphological changes caused by lipophilic

acids in mammalian cells, 2457 Manipulation of fatty acid composition in animal cells grown in

culture, 3669 Squalene and sterol carrier protein: structural properties,

lipid-binding, and function in cholesterol biosynthesis, 265 Federal and academic relationships

From knowledge to action: science and its uses (Scientific Program of National Academy of Sciences USA, Autumn 1973 Meeting), 3934

Feedback Feedback-resistant phosphoribosylpyrophosphate synthetase,

characterization from cultured, mutagenized hepatoma cells that overproduce purines, 3698

Ferredoxin Electron paramagnetic resonance of nitrogenase and nitrogenase


Hydrogen evolution by chloroplast-ferredoxin-hydrogenase system, 2317

Synthetic analogs of active sites of iron-sulfur proteins: structure and properties of bis[o-xylyldithiolato-g2-sulfidoferrate (III)], an analog of 2Fe-2S proteins, 2429

Ferricytochrome c Cytochrome c, observation of numerous single-carbon sites of

reduced and oxidized species by natural-abundance 13C nuclear magnetic resonance spectroscopy, 3531


Ferritin see also Immunoferritin Ultrastructure of ferritin macromolecules: lattice structure of

core crystallites, 3847 Ferrocytochrome c


Fertility Fertility, IQ, and school achievement (abstract), 3935

Fertilization see also Mating; Pollination; Self-fertilization Polyadenylation of maternal RNA of sea urchin eggs after

fertilization, 2345 Fetal liver

Hepatic glycogen synthesis, regulation during fetal development: roles of hydrocortisone, insulin, and insulin receptors, 3454

ai-Fetoprotein Radioimmunoassay for human alpha1-fetoprotein, 526

Fibrin Discriminating neoantigenic differences between fibrinogen and

fibrin derivatives, 1169 Fibroblast, chick-embryo

Hypoxanthine phosphoribosyltransferase activity, restoration in mouse IR cells after fusion with chick-embryo fibroblast, 1998

Sugar transport in normal and Rous sarcoma virus-transformed chick-embryo fibroblasts, 653


Fibroblast, chicken Roles of calcium, serum, plasma, and folic acid in control of

proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts, 675

Fibroblast, human Cystic fibrosis: fractionation of fibroblast media that inhibits

ciliary activity, 548 Defect in Hunter syndrome: deficiency of sulfoiduronate

sulfatase, 2134 Epidermal growth factor: receptors in human fibroblasts and

modulation of action by cholera toxin, 2964 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity,

regulation in human fibroblasts by lipoproteins, 2162 Secretion and extracellular processing of procollagen by cultured

human fibroblasts, 361 Fibroblastic mouse cell line


Fibroblast, L-929 Cell-free synthesis of procollagen: L-929 fibroblasts as cellular

model for dermatosparaxis, 1378 Prolyl hydroxylase activation in L-929 fibroblasts by ascorbic

acid, 1090 Fibroblast, mouse

Adenosine 3' :5'-cyclic monophosphate, role in early transport changes induced by serum and insulin in quiescent fibroblasts, 3609

Adrenal corticosteroids enhance production of type-C virus induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts, 2391

Cell contact-dependent increase in membrane D-galactopyranosyl-like residues on normal, but not virus- or spontaneously-transformed, murine fibroblasts, 1672

Concanavalin A-binding sites, comparative evaluation of distribution on surfaces of normal, virally-transformed, and




protease-treated fibroblasts, 1625 Mutant of 3T3 cells with cyclic AMP metabolism sensitive to

temperature change, 2906 Ribonucleic acid synthesis, regulation in fibroblasts during

transition from resting to growing state, 2819 Fibroblast, neoplastic


Fingerprinting technique Fingerprinting techniques, application to iodinated nucleic acids,

3260 Firefly

1,N6-Ethenoadenosine triphosphate and 1,N6-ethenoadenosine monophosphate, role in firefly luminescence, 1664

Fish see also Electrophorus; Euthynnus lineatus; Squalus acanthius Wax in coral mucus feeds tropical reef fishes (abstract), 3935

Fish, warm-bodied Heat exchange in black skipjack, and blood-gas relationship of

warm-bodied fishes, 1964 Fixation procedure

Erythrocyte ghost ultrastructure, preservation achieved by various fixatives, 3060

Flagellin Amino-acid sequence of flagellin from Bacillus subtilis 168:

comparison with other bacterial flagellins, 3428 Flavin adenine dinucleotide

Flavin 1,N6-ethenoadenine dinucleotide: dynamic and static quenching of fluorescence, 941

Flavin intermediate Spectral properties of oxygenated luciferase-flavin intermediate

isolated by low-temperature chromatography, 3468 Flavin 1,N6-ethenoadenine dinucleotide


Flavodoxin Proton magnetic resonance spectra, dependence on oxidation

state of flavodoxin from Clostridium MP and from Peptostreptococcus elsdenii, 3292

Riboflavin-5'-phosphate, binding in flavoprotein: flavodoxin at 2.0-angstrom resolution, 3857

Flavoprotein Riboflavin-5'-phosphate, binding in flavoprotein: flavodoxin at

2.0-angstrom resolution, 3857 Flower

Polymorphism for interspecific cross-compatibility in Phlox, 1149 Ultraviolet patterns on rear of flowers: basis of disparity of buds

and blossoms, 1002 Fluorescence

see also Tryptophan fluorescence; Immunofluorescence; Probe, fluorescent

Dansyl-galactoside: fluorescent probe of active transport in bacterial membrane vesicles, 2722


Tyrosyl residue, role in mechanism of action of carboxypeptidase B: luminescence studies, 2025

fMet-tRNA see Ribonucleic acid, transfer, methionyl (formylatable)

Folic acid 5-Methyltetrahydrofolate: homocysteine methyltransferase

activity, regulation by methionine, vitamin B12, and folate in cultured baby hamster kidney cells, 2585


Food "Trophic" value of foods, 710

Food additive Growth inhibition and morphological changes caused by lipophilic

acids in mammalian cells, 2457 Fossil

Biological versatility and earth history, 1936 Fossil bones

Racemization reaction of aspartic acid and its use in dating fossil bones, 1331

Fourier transform spectra Nuclear magnetic resonance spectroscopy: 13C fourier transform

spectra of A- and A9-tetrahydrocannabinol, 1027 Free radical

Charge transfer between amine and carbonyl, 3139 Free radical detection in primary reaction of chloroplast

photosystem II, 294 Freeze-fracturing

Gap junctions between photoreceptor cells in the vertebrate retina, 1677

Frog see also Rana catesbiana; Rana pipiens Membrane sealing in frog skeletal-muscle fibers, 982

Fructose 1,6-bisphosphatase see also Hexosediphosphatase Neutral to alkaline conversion of liver fructose


Fructose-1,6-diphosphate aldolase see Ketose-l-phosphate aldolase

Fruiting body maturation Genetically related protein variants specifically associated with

fruiting body maturation in Neurospora, 1891

Fusidic acid Adenosine triphosphatase and guanosine triphosphatase activities

associated with specific 5S RNA-protein complex, 2870 Fv region

Localization of idiotypic antigenic determinants in Fv region of murine myeloma protein MOPC-315, 1585

Galactitol accumulation Carbohydrate catabolism and enhancement of uptake of galactose

in hamster cells transformed by polyoma virus, 839 D-Galactopyranose

Cell contact-dependent increase in membrane D-galactopyranosyl-like residues on normal, but not virus- or spontaneously-transformed, murine fibroblasts, 1672

Galactose Carbohydrate catabolism and enhancement of uptake of galactose

in hamster cells transformed by polyoma virus, 839 Galactose uptake into hamster cells, two distinct types of

enhancement: tumor-virus transformation and hexose starvation, 2502

Interferon: evidence for its glycoprotein nature, 1981 Population analysis of deinduction kinetics of galactose long-term

adaptation mutants of yeast, 919 Galactose-binding protein

3-Methylgalactoside transport system and galactose-binding protein, regulation by cell cycle of Escherichia coli, 1481

Galactose oxidase (EC 1.1.3.9) Induction of lymphocyte transformation by sequential treatment

with neuraminidase and galactose oxidase, 1824 Malignant cells, altered growth behavior associated with changes

in externally labeled glycoprotein and glycolipid, 3329 f-Galactosidase

Evolution of second gene for /3-galactosidase in Escherichia coli, 1841

/-Galactosidase (EC 3.2.1.23) Splicing of protein in vivo: one continuous polypeptide from two

independently functioning operons, 2969 ;-Galactoside

Anaerobic transport in Escherichia coli membrane vesicles, 3376 Galactoside, proton-coupled accumulation in Streptococcus

lactis 7962, 2866 Galactoside, dansyl-


Galaxy Asymptotics of some relativistic Markov processes, 3551 Quasars as events in galaxy nuclei (abstract), 2179

gam gene -y-Protein specified by bacteriophage A, purification and

properties: inhibitor of host RecBC recombination enzyme, 2215 Ganglion

see Sensory ganglion Gap junction


Gaucher's disease Enzyme loading of erythrocytes, 2663

Gene see also dna gene; gam gene; N gene; Ss-Slp gene; T-antigen

gene; tof gene; Tr gene Carcinogenesis, general theory, 3324 Globin gene, tissue-specific transcription in isolated chromatin,

3440 Light-chain gene reiteration of mouse immunoglobulin, estimation

of, by DNA.RNA hybridization, 173 Nucleotide sequence divergence in se-chain-structural genes of


Relative orientation with respect to centromere of ribosomal RNA genes of X and Y chromosomes of Drosophila melanogaster, 1883


Gene expression Autoregulation: role for biosynthetic enzyme in control of gene

expression, 2757 Gene isolation

General method of gene isolation, 1697 Gene localization

Iodinated RNA, use for gene localization, 1860 Lambda-chain production in human lymphoblast-mouse

fibroblast hybrids, 2401 Loci for human PGM1 and 6PGD, regional localization on human


Gene, regulatory Mutational analysis of regulatory gene for morphogenesis in

Schizophyllum, 1427 Genetic analysis

Genetic analysis of developmental stages of cellular slime mold Dictyostelium purpureum, 2003

Genetic control Genetic control of development in Volvox: isolation and

characterization of morphogenetic mutants, 1335 Genetic fusion

Genetic fusion of incompatible plasmids in Pseudomonas, 1641 Genetic linkage disequilibrium

Adaptive linkage disequilibrium between two esterase loci of




salamander, 1156 Genetic linkage group

Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids, 1268

Genetic loci Independent segregation of loci for activation of biologically

distinguishable RNA C-type viruses in mouse cells, 2055 Genetic mapping

Evolution of second gene for /-galactosidase in Escherichia coli, 1841

Genetic mapping of inversion loop in bacteriophage Mu DNA, 2153

Genetic marker discrimination Marker discrimination in transformation and mutation of

pneumococcus, 3541 Genetic method

Genetic method for determining order of events in biological pathway, 2046

Genetic recombination Crossing-over between X and Y chromosomes during ribosomal

DNA magnification in Drosophila melanogaster, 1950 Deoxyribonucleic acid repair that contains interstrand crosslinks

in Escherichia coli: sequential excision and recombination, 1064 Genetic system in parthenogenetic strains of Drosophila

mercatorum, 1772 y-Protein specified by bacteriophage X, purification and

properties: inhibitor of host RecBC recombination enzyme, 2215 Genetic regulation

Genetically related protein variants specifically associated with fruiting body maturation in Neurospora, 1891

Genetic regulation of octane dissimilation plasmid in Pseudomonas, 1137

HL-A-linked human immune-response genes, 2157 Human regulatory gene for inducible tyrosine aminotransferase

in rat-human hybrids, 1268 Regulation of expression of N gene of bacteriophage lambda, 421

Genetic repair Cytogenetic engineering in vivo: restoration of biologic

complement activity to C5-deficient mice by intravenous inoculation of hybrid cells, 3125

Genetic research Protoplasts, use for genetic research (N.A.S. Symposium: plant

growth regulation), 598 Genetics

see Behavior genetics Genetic suppression

Adjacent transfer RNA genes in Escherichia coli, 438 Genetic transmission


Genetic variants "Private" genetic variants and frequency of mutation among

South American Indians, 3311 Genetic variation

Gene diversity, analysis in subdivided populations, 3321 Genetic variability in natural populations, 3928 Human phosphoribosylpyrophosphate synthetase: increased

enzyme specific activity in family with gout and excessive purine synthesis, 2749

Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in family with gout and excessive purine synthesis (correction), 3932

Genic variability Genic variability and strategies of adaptation in animals, 1875

Genome Drosophila genome, proposal for structure of, 535

Genome, mitochondrial Mitochondria, autonomy of, in Saccharomyces cerevisiae in

production of messenger RNA, 111 Geology

see also Earth Ecological theory for sudden origin of multicellular life in late

Precambrian, 1486 Internal swash and surf, 2379

Geophysics Seismological inverse problemn: informative solution, 1410 Surface circulation of lakes and nearly land-locked seas, 93

Germacranolide Neutron diffraction structure of melampodin: its role in

reclassification of germacranolides, 2434 Neutron diffraction structure of melampodin: its role in

reclassification of germacranolides (correction), 3932 Glial cell

see Bergmann glia Glial-neuronal interaction

Glia-induced morphological differentiation in neuroblastoma cells, 1894

Globin Globin gene, tissue-specific transcription in isolated chromatin,

3440 Globin messenger sequences in giant nuclear precursors of

messenger RNA of avian erythroblasts, 1122 Primer requirement and template specificity of DNA polymerase

of chick embryo, 1229 Globin chain

Contribution of a and 1 chains to kinetics of oxygen binding to and dissociation from hemoglobin, 1

Delayed removal of amino-terminal methionine from nascent globin chains in sickle-cell anemia reticulocytes, 2059

Subject Index 21

Hemoglobin :-chain synthesis, regulation in bone marrow erythroid cells by a chains, 3405

Pyridoxal compounds as specific reagents for a and 3 N-termini of hemoglobin, 2595

Globular protein Globular protein, prediction of amount of secondary structure

from amino acid composition, 2809 Nucleation, rapid folding, and globular intrachain regions in

proteins, 697 Reverse turn as polypeptide conformation in globular proteins,

538 Glucagon

Early differentiation of glucagon-producing cells in embryonic pancreas: possible developmental role for glucagon, 3478

Glucagon-containing peptide: isolation and primary structure of possible fragment of proglucagon, 2321

Glucose synthesis, regulation in hormone-sensitive isolated rat hepatocytes, 3213


a-Glucan phosphorylase (EC 2.4.1.1) Hydrophobic chromatography: use for purification of glycogen

synthetase, 778 i- Glucocerebrosidase Enzyme loading of erythrocytes, 2663

Glucocorticoid hormone see also Corticosteroid Adrenal glucocorticoids, effects on polyoma virus replication,

1088 Deoxyribonucleic acid synthesis, suppression in hepatoma cells

exposed to glucocorticoid hormone in vitro, 3852 Hepatic glycogen synthesis, regulation during fetal development:

roles of hydrocortisone, insulin, and insulin receptors, 3454 Hepatic /-hydroxy-/-methylglutaryl coenzyme A reductase

activity, stimulation in hypophysectomized rats by L-triiodothyronine, 3839


Nuclear binding of steroid receptors: comparison in intact cells and cell-free systems, 3415

Pituitary extracts and steroid hormones in control of 3T3 cell growth, 2702

Gluconeogenesis Fructose 1,6-biphosphatase: role of lysosomal enzymes in

modification of catalytic and structural properties, 303 Glucose

see also 3-O-Methylglucose Glucose metabolism

Alteration in glucose metabolism associated with defect in ketone body metabolism, 210

Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) Hypoxanthine phosphoribosyltransferase, reexpression of rat

gene in rat-human hybrids, 2590 Monoclonal origin of human atherosclerotic plaques, evidence for,

1753 Glucose phosphomutase

see Phosphoglucomutase Glucose synthesis


Glucose transport Deoxyglucose transport, growth and density-dependent inhibition

in Balb 3T3 cells and its absence in cells transformed by murine sarcoma virus, 2374


Membrane lipids, lateral phase separations and mechanism of sugar transport in Escherichia coli, 2271


Glucose utilization Measurements of rates of adenosine 3':5'-cyclic monophosphate

synthesis in intact Escherichia coli B, 2149 Glutamate


Glutamine Different mechanisms of energy coupling for active transport of

proline and glutamine in Escherichia coli, 1514 Glutamine amidotransferase

Glutaminase activity of glutamine amidotransferase (carbamylphosphate synthetase), pH dependence, 2717

Glutamine synthetase (EC 6.3.1.2) E-Adenylated glutamine synthetase: internal fluorescence probe

for enzyme conformation, 3134 Glutamine synthetase induction in embryonic neural retina:

immunochemical identification of polysomes involved in enzyme synthesis, 1667

y-Glutamyl cycle y-Glutamyl cycle, enzymes in ciliary body and lens, 2211 -y-Glutamyl cycle in choroid plexus: its possible function in amino

acid transport, 1447 Glyceraldehydephosphate dehydrogenase (EC 1.2.1.12)

D-Glyceraldehyde-3-phosphate dehydrogenase: three-dimensional structure and evolutionary significance, 3052

Glycerolphosphate acyltransferase (EC 2.3.1.15) Macromolecular biosynthesis, regulation in mutant of

Escherichia coli defective in membrane phospholipid




biosynthesis, 385 Glycine receptor


Glycogen, hepatic Hepatic glycogen synthesis, regulation during fetal development:

roles of hydrocortisone, insulin, and insulin receptors, 3454 Glycogen phosphorylase

see a-Glucan phosphorylase Glycogen synthase

see Uridine diphosphate glucose-glycogen glucosyltransferase Glycolipid

Malignant cells, altered growth behavior associated with changes in externally labeled glycoprotein and glycolipid, 3329

Glycopeptide Glycopeptides from surface membranes of neuroblastoma cells,

1682 Glycoprotein

Cell-surface glycoproteins of mouse embryos: change before implantation, 1645

Dopamine-l-hydroxylase: tetrameric glycoprotein, 2253 Glycoproteins from patients with alveolar proteinosis, 973 Interferon: evidence for its glycoprotein nature, 1981 Lipid-bound oligosaccharides that contain mannose, formation

and role in glycoprotein synthesis, 3390 Lipopolysaccharide protein, isolation and characterization from

Escherichia coli, 2572 Malignant cells, altered growth behavior associated with changes

in externally labeled glycoprotein and glycolipid, 3329 N-Acetyl-D-galactosaminyltransferases produced by human Al

and A2 genes, qualitative differences, 220 Papain-solubilized HL-A antigens from cultured human

lymphocytes contain two peptide fragments, 1603 Glycosaminoglycan


Goitrogen N-Iodosuccinimide reaction with goitrogens: model for active

iodine of thyroid gland, 1401 Gonadotropin, chorionic

Subunits of human chorionic gonadotropin: unbalanced synthesis and secretion by clonal cell strains derived from bronchogenic carcinoma, 1419

Gout Human phosphoribosylpyrophosphate synthetase: increased



Granulocyte see also Leukocyte Control of normal differentiation of myeloid leukemic cells to

macrophages and granulocytes, 343 Mobility of carbohydrate-containing structures on surface


Grapsus Synaptic differentiation in regenerating crab-limb muscle, 822

Grass see Avena sativa

Growth see also Cell growth

Growth, control of Pleiotypic control by adenosine 3':5'-cyclic monophosphate: model

for growth control in animal cells, 1432 Growth factor

see Nerve growth factor Growth hormone

see also Pituitary growth hormone Cell-free synthesis of rat growth hormone, 3646

Growth inhibition Growth inhibition and morphological changes caused by lipophilic

acids in mammalian cells, 2457 Growth of malignant cells

Malignant cells, altered growth behavior associated with changes in externally labeled glycoprotein and glycolipid, 3329

Guanine nucleotide Guanine nucleotides and elongation factors, influence on

interaction of release factors with ribosome, 2350 Guanosine 3':5'-cyclic monophosphate



Guanosine 3' :5'-cyclic monophosphate and action of insulin and acetylcholine, 2443




Photoreceptors, regulation of cyclic nucleotide concentrations: ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light, 3820


Guanosine pentaphosphate Guanine nucleotides, role in protein synthesis: elongation factor G

and guanosine 5'-triphosphate,3'-diphosphate, 3250 Guanosine tetra- and pentaphosphate synthesis requires presence

of codon-specific, uncharged transfer ribonucleic acid in acceptor site of ribosomes, 1564

Nonribosomal synthesis of guanosine 5',3'-polyphosphates by ribosomal wash of stringent Escherichia coli, 2145

Guanosine tetraphosphate Guanosine 5'-diphosphate, 3'-diphosphate: assignment of structure

by "3C nuclear magnetic resonance spectroscopy, 2563 Guanosine tetra- and pentaphosphate synthesis requires presence


Guanosine tetraphosphate (MS I), identification of, as insertion of pyrophosphoryl group into 3'-position in guanosine 5'-diphosphate, 306

Nonribosomal synthesis of guanosine 5',3'-polyphosphates by ribosomal wash of stringent Escherichia coli, 2145

Guanosine triphosphatase Adenosine triphosphatase and guanosine triphosphatase activities

associated with specific 5S RNA-protein complex, 2870 Proteins S5 and S9 from 30S subunits, requirement for

ribosome-dependent GTPase activity of elongation factor G, 151 Guanosine triphosphate

Protein initiation in eukaryotes: ternary complex composed of partially purified ribosomal factor, methionyl transfer RNAf, and guanosine triphosphate, 41

Guanylate kinase (EC 2.7.4.8) Guanosine 3':5'-cyclic monophosphate, new enzymatic assay and

its application to ductus deferens of rat, 1721 Guanylyl-3',5'-cytidine

Crystalline fragment of double helix: structure of dinucleoside phosphate guanylyl-3',5'-cytidine, 849

P- (5'-Guanylyl) methylenebisphosphonate Factor-promoted dissociation of free ribosomes in rabbit

reticulocyte lysate system: inhibition and requirement for energy source, 787

Gyrodinium cohnii 5-Hydroxymethyluracil in DNA of dinoflagellate, 1141

Hapten Antibodies with multiple binding functions: induction of single

immunoglobin species by structurally dissimilar haptens, 3269 Hardy-Weinberg frequency



Hartree-Fock model Computation of large molecules with Hartree-Fock model

(correction), 284 Hearing, avian

Continuous noise, effects on avian hearing and vocal development, 1393

Heat exchange Heat exchange in black skipjack, and blood-gas relationship of

warm-bodied fishes, 1964 Heavy water

see Deuterium oxide Hebb's postulate of learning

Hebb's postulate of learning: physiological mechanism, 997 HeLa cell


Cytoplasmic messenger RNA stability in HeLa cells, 115 HeLa cell deoxyribonucleic acid, breakdown mediated by

vaccinia virus, 3200 Long pyrimidine polynucleotides, analysis in HeLa cell nuclear

DNA: absence of polydeoxythymidylate, 2189 Poly(inosinic acid) poly(cytidylic acid) inhibition of DNA

synthesis in synchronized HeLa cells, 3904 Secondary structure maps of RNA: processing of HeLa ribosomal

RNA, 2827 Heliomagnetic-geomagnetic modulation

Heliomagnetic-geomagnetic modulation of radiocarbon production in earth's atmosphere (abstract), 2178

Helium-3-helium-4 solution Relation between X lines and phase separations, 1241

Helix-coil transition Helix-coil transition for poly(L-alanine) as measured by nuclear

magnetic resonance, 331 Helminthosporium sacehari

Biochemical basis of resistance of sugarcane to eyespot disease, 1693

Heme Myoglobin, synthesis of active site, 2647

Heme protein Heme proteins: effect of intermediate on photochemical behavior,

1550 Heme proteins: quantum yield determined by pulse method, 3141 Spin-state correlations in near infrared spectroscopy of

cytochrome c', 1851 Hemerythrin

Resonance Raman studies of electronic state of oxygen in hemerythrin, 2582

Hemin Hemin effect on synthesis of hemoglobin and other proteins in




mammalian cells, 1022 Hemocyanin

Magnetic dipole-dipole coupled Cu(II) pairs in nitric oxide-treated tyrosinase: structural relationship between active sites of tyrosinase and hemocyanin, 993

Hemoglobin see also Ribonucleic acid, messenger, globin; Sickle cell

hemoglobin Carbon dioxide and bicarbonate interaction with human

hemoglobin preparations, 1414 Contribution of a and ft chains to kinetics of oxygen binding to

and dissociation from hemoglobin, 1 Heat exchange in black skipjack, and blood-gas relationship of

warm-bodied fishes, 1964 Interpretation of binding of carbon monoxide to hemoglobin under

photodissociating conditions, 673 Measurement of pK values of alkaline Bohr group in human

hemoglobin, 1246 Pyridoxal compounds as specific reagents for a and ft N-termini

of hemoglobin, 2595 Statistical mechanics applied to cooperative ligand binding to

proteins, 3914 Stereochemical trigger for initiating cooperative interaction of

subunits during oxygenation of cobaltohemoglobin, 3919 Thalassemia syndromes, quantitative deficiency of chain specific

messenger ribonucleic acids, 1809 Hemoglobin A

Hemoglobin switching in sheep and goats: erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures, 1739

Oxygen equilibrium and kinetics of isolated subunits from hemoglobin Kansas, 1718

Hemoglobin C Hemoglobin switching in sheep and goats:

erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures, 1739

Hemoglobin $-chain Hemoglobin d/-chain synthesis, regulation in bone marrow

erythroid cells by a chains, 3405 Hemoglobin H

Thalassemia, decreased globin messenger RNA detected by molecular hybridization, 1886

Hemoglobin Kansas Oxygen equilibrium and kinetics of isolated subunits from

hemoglobin Kansas, 1718 Hemoglobin M Boston

Structure of hemoglobin M Boston, variant with five-coordinated ferric heme, 3870

Hemoglobin S see also Sickle cell hemoglobin Acetylation of sickle cell hemoglobin by aspirin, 1313 Concerted formation of gel of hemoglobin S, 1506 Hemoglobin S, structure and optical determination of molecular

orientation in sickled erythrocytes, 3604 Human sickle-cell erythrocytes, survival in heterologous species:

response to variations in oxygen tension, 2356 Hemoglobin S, deoxy-

Concerted formation of gel of hemoglobin S, 1506 Structure of sickled erythrocytes and of sickle-cell hemoglobin

fibers, 718 Hemoglobin synthesis



Discrimination between messenger ribonucleic acids by mammalian translation initiation factor, 2139


Hemin effect on synthesis of hemoglobin and other proteins in mammalian cells, 1022

Hemophilia Factor VIII recombination after dissociation by CaC12, 2326 Plasma aggregating factor (bovine) for human platelets: marker

for study of antihemophilic and von Willebrand factors, 2814 Hepatitis

Radioimmunoassay for human alphai-fetoprotein, 526 Hepatocytes


Protein of molecular weight 78,000 bound to polyadenylate region of eukaryotic messenger RNAs, 924

Hepatoma cell see also Novikoff hepatoma Deoxyribonucleic acid synthesis, suppression in hepatoma cells

exposed to glucocorticoid hormone in vitro, 3852 Feedback-resistant phosphoribosylpyrophosphate synthetase,


Hepatoma cell hybrid Differentiated functions in hepatoma cell hybrids: expression of

alanine aminotransferase, 377 Hepatotoxicity

Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine, 747

Heroin see also Cocaine; Narcotic Methadone plasma level: sustained by reservoir of drug in tissue,

10

Subject Index 23

Herpes genitalis virus Herpes simplex and genitalis virus nonvirion antigens: use for



Herpes simplex virus 5-Bromodeoxycytidine, phosphorylation in cells infected with

herpes simplex virus, 3788 Herpes simplex and genitalis virus nonvirion antigens: use for



Herpes simplex virus as source of thymidine kinase for thymidine kinase-deficient mouse cells: suppression and reactivation of viral enzyme, 1912

Infectious deoxyribonucleic acid from herpes simplex virus: infectivity of double-stranded and single-stranded molecules, 3621

Nonvirion antigens produced by herpes simplex viruses 1 and 2, 1032

Post-transcriptional adenylation of herpes virus RNA, relationship with messenger RNA abundance, 2101

Heterocyst Differentiation in Nostoc muscorum: nitrogenase is synthesized in

heterocysts, 2727 Heterokaryocyte

Environmental pH effect on rescue of simian virus 40, 366 Heterologous transfusion

Human sickle-cell erythrocytes, survival in heterologous species: response to variations in oxygen tension, 2356

Hexosediphosphatase (EC 3.1.3.11) Changes in rabbit-liver lysosomes and fructose

1,6-bisphosphatase induced by cold and fasting, 3674 Fructose 1,6-biphosphatase: role of lysosomal enzymes in

modification of catalytic and structural properties, 303 Hilbert space

Minimax principles for solution of semilinear gradient operator equations in Hilbert space, 1519

Hill oxidant Oxaloacetate as Hill oxidant in mesophyll cells of plants


Histamine-sensitizing factor, locus for H-2 locus and locus for responsiveness to histamine-sensitizing

factor, independent segregation of, 2500 Histidine

Histidine operon, inhibition of transcription in vitro by first enzyme of histidine pathway, 2692 -

Measurement of pK values of alkaline Bohr group in human hemoglobin, 1246

Self-regulated repressor protein of hut operons of Salmonella typhimurium, isolation of, 808

Histidinol phosphate Illicit transport: oligopeptide permease, 456

Histocompatibility see also HL-A Cellular basis for genetically controlled immunologic

unresponsiveness in mice: tolerance induction in T-cells, 250 Histocompatibility-2-linked Ss-Slp region, role in control of mouse

complement, 863 Human complement, activation by human lymphoid cells

sensitized with histocompatibility alloantisera, 3665 Human 032-microglobulin, multiple common properties and

common portion fragment derived from HL-A antigen molecules, 2863


Histocompatibility locus Cell interactions between histoincompatible T and B lymphocytes:

H-2 gene complex determines successful physiologic lymphocyte interactions, 2624

HL-A variants in cultured human lymphoid cells: isolation and characterization, 1397

H-2 locus and locus for responsiveness to histamine-sensitizing factor, independent segregation of, 2500

New lymphocyte antigen system (Lna) controlled by Ir region of mouse H-2 complex, 2509

Histone Cell-free translation of maternal messenger RNA from sea urchin

eggs, 2614 Histones, addition to histone-depleted nuclei: effect on template

activity toward DNA and RNA polymerases, 2637 Histones, blocking of accessibility to DNA in chromatin: addition

of histones (correction), 627 Lysine-rich histones of maize (Zea mays), two independently

inherited electrophoretic variants, 3043 Maternal histone messenger RNA: detection by molecular

hybridization, 2840 Selective extraction of histones, effects on template activities of


Histone kinase Phosphorylation of ribosomal proteins by substrate-specific

protein kinases from rabbit reticulocytes, 373 HL-A

see also Histocompatibility



24 Subject Index

HL-A antibodies Human complement, activation by human lymphoid cells

sensitized with histocompatibility alloantisera, 3665 HL-A antigen

Human 32-microglobulin, multiple common properties and common portion fragment derived from HL-A antigen molecules, 2863


HL-A haplotype HL-A-linked human immune-response genes, 2157

HL-A variant HL-A variants in cultured human lymphoid cells: isolation and

characterization, 1397 HLB number

Detergent hydrophobic lipophilic balance (HLB) number, relation to solubilization and stabilization of D-alanine carboxypeptidase from Bacillus subtilis membranes, 2997

Hodgkin-Huxley equation Relaxation spectra of potassium channel noise from squid axon

membranes, 876 Hodgkin's disease

Deoxyribonucleic acid, unique nuclear sequences in involved tissues of Hodgkin's and Burkitt's lymphomas, 3810

Purification of Hodgkin's disease tumor-associated antigens, 396 Tumor antigen in tissue cultures derived from patients with

Hodgkin's disease, 1540 Homarus americanus


Locomotor patterns, development in absence of peripheral sense organs and muscles, 954

Hominid Racemization reaction of aspartic acid and its use in dating fossil

bones, 1331 Homology, sequence


Sequence homology at the 5'-termini of insect messenger RNAs, 1355

Hormone see specific hormones

Host defense system Stimulation of host defense system by coenzyme Qio, effect on


Host-gene control Host-gene control of type-C RNA tumor virus expression and

tumorigenesis in inbred mice, 1450 Host restriction

Friend leukemia virus, host restriction: role of viral outer coat, 2549

Hunter syndrome Defect in Hunter syndrome: deficiency of sulfoiduronate

sulfatase, 2134 Hutchinson-Gilford progeria syndrome

Deficient DNA repair in human progeroid cells, 977 Hyaluronic acid

Mucopolysaccharides, production by normal and transformed cells, 54

Hybrid cell, chick-Chinese hamster Chick chromosomes, identification in cell hybrids formed between


Hybrid cell, Chinese hamster-human Loci for human PGM1 and 6PGD, regional localization on human


Hybrid cell, hepatoma-epithelial Differentiated functions in hepatoma cell hybrids: expression of

alanine aminotransferase, 377 Hybrid cell, human somatic

Microsurgically fused human somatic cell hybrids: analysis and cloning, 3382

Hybrid cell, lymphoblast-fibroblast Lambda-chain production in human lymphoblast-mouse

fibroblast hybrids, 2401 Hybrid cell, monkey-mouse

Interferon uptake in parental and somatic monkey-mouse hybrid cells, mechanism of, 557

Hybrid cell, mouse-human T-antigen gene of simian virus 40, assignment to human

chromosome C-7, 3617 Hybrid cell, rat-human

Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids, 1268

Hypoxanthine phosphoribosyltransferase, reexpression of rat gene in rat-human hybrids, 2590

Hybrid cells Cytogenetic engineering in vivo: restoration of biologic


Hybridization, molecular Maternal histone messenger RNA: detection by molecular

hybridization, 2840 Natural host taxonomy of RNA tumor viruses, determination by



Natural host toxonomy of RNA tumor viruses, determination by molecular hybridization: application to RD-114, a candidate human virus (correction), 2176

Type-C viruses of various species, homology as determined by molecular hybridization, 3316

Hybrid nuclease Avian myeloblastosis virus, single subunit with both




Ribonuclease H of calf thymus: purification and properties, 1959 Hybrid population, human



Mathematical models for assortative mating in American Negro populations resulting in correlation between fractions of Caucasian ancestry (abstract), 1619

Hydration Carbon dioxide hydration activity of carbonic anhydrase:

paradoxical consequences of unusually rapid catalysis, 1986 Hydrazine


Hydrocortisone see Glucocorticoid hormone

Hydrogenase Hydrogen evolution by chloroplast-ferredoxin-hydrogenase

system, 2317 Hydrogen bond

Hydrophobicity of long chain n-alkyl carboxylic acids as measured by their distribution between heptane and aqueous solutions, 289

Hydrogen-bonded ring proton Watson-Crick base pairs, nuclear magnetic resonance study of

hydrogen-bonded ring protons, 2899 Hydrophobicity

Hydrophobicity of long chain n-alkyl carboxylic acids as measured by their distribution between heptane and aqueous solutions, 289

Hydrophobic protein Atypical pattern of utilization of amino acids for mitochondrial

protein synthesis in HeLa cells, 1490 Hydrostatic pressure

Negative hydrostatic pressure in solvent is basis for all colligative properties of solution (abstract), 2178


3-Hydroxybutyrate dehydrogenase (EC 1.1.1.30) Peptide fragments of apolipoprotein-alanine: chemical synthesis

and biochemical properties, 2124 lo-Hydroxycholecalciferol

la-Hydroxycholecalciferol, synthetic analog of hormonal form of vitamin D3: biological activity, 2248

Hydroxymethylglutaryl coenzyme A reductase (EC 1.1.1.34) Familial hypercholesterolemia: identification of defect in

regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol, 2804

Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, stimulation in hypophysectomized rats by L-triiodothyronine, 3839

3-Hydroxy-3-methylglutaryl coenzyme A reductase activity, regulation in human fibroblasts by lipoproteins, 2162

5-Hydroxymethyluracil 5-Hydroxymethyluracil in DNA of dinoflagellate, 1141

Hydroxyphenylazopyrimidine Deoxyribonucleic acid polymerase from Bacillus subtilis,

inhibition by hydroxyphenylazopyrimidines, 103 Hydroxyphenylazopyrimidines: characterization of active forms


Hydroxyurea Sequence of spontaneous Epstein-Barr virus activation and

selective DNA synthesis in activated cells in presence of hydroxyurea (correction), 284

Hypercholesterolemia see Familial hypercholesterolemia

Hyperlipidemia see Primary dysbetalipoproteinemia

Hyperuricemia Feedback-resistant phosphoribosylpyrophosphate synthetase,


Hypothalamus Primary structure of somatostatin: hypothalamic peptide that

inhibits secretion of pituitary growth hormone, 684 Tertiary structure for the hypothalamic thyrotropin-releasing

factor, 1166 Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8)

Drug-resistant variants of mammalian tissue culture cells, altered enzymes, 3145


Hypoxanthine phosphoribosyltransferase, reexpression of rat




gene in rat-human hybrids, 2590 Mutations affecting structure of hypoxanthine: guanine

phosphoribosyltransferase in cultured Chinese hamster cells, 320

Purine metabolism in normal and thioguanine-resistant neuroblastoma, 3880


Hypoxia Human sickle-cell erythrocytes, survival in heterologous species:

response to variations in oxygen tension, 2356

Identical twins Leukemia-specific DNA sequences in leukocytes of leukemic

member of identical twins, 2629 Idiotypic antigenic determinant


2-Imidazolidone-4-carboxylic acid 5-Oxoprolinase inhibition by 2-imidazolidone-4-carboxylic acid,

759 Immune response

Allograft tolerance: presumptive evidence that serum factors from tolerant animals that block lymphocyte-mediated immunity in vitro are soluble antigen-antibody complexes, 2539

Cellular basis for genetically controlled immunologic unresponsiveness in mice: tolerance induction in T-cells, 250

HL-A-linked human immune-response genes, 2157 Immune response region

New lymphocyte antigen system (Lna) controlled by Ir region of mouse H-2 complex, 2509

Immunization Attempt to immunize guinea pigs against leukemia by skin

scarification with leukemic cell suspensions, 3432 Prophylaxis and immunization in mice by use of virus-free

defective T particles to protect against intracerebral infection by vesicular stomatitis virus, 2105

Immunoadsorbent, solid-phase Mouse interferon, purification of, by affinity chromatography on

solid-phase immunoadsorbent, 1037 Immunoelectronmicroscopy

Cell-surface antigen associated with murine sarcoma virus by immunoelectronmicroscopy, 742

Topographical location of H-Y antigen on mouse spermatozoa by immunoelectronmicroscopy, 1502

Immunoferritin Immunoferritin localization of intracellular antigens: use of


Immunofluorescence Chromosome structure as revealed by combined chemical and

immunochemical procedure, 804 Immunogenicity

Simian virus 40 tumors, prevention by hamster fetal tissue: influence of parity status of donor females on immunogenicity of fetal tissue and on immune cell cytotoxicity, 183

Immunoglobulin E Immunological tolerance, induction in bone marrow-derived

lymphocytes of IgE antibody class, 2776 Immunoglobulin G

Human anti-IgM iso-antibodies: detection of IgM allotypic markers, 827

Oligoclonal immunoglobulin G antibody response in central nervous system to different measles virus antigens in subacute sclerosing panencephalitis, 1060

Immunoglobulin gene Protein Hal: partial deletion of "-y" immunoglobulin gene(s) and

apparent reinitiation at internal AUG codon, 1073 Immunoglobulin M

Human anti-IgM iso-antibodies: detection of IgM allotypic markers, 827



Production of noncovalently bonded pentamer of immunoglobulin M: relationship to J-chain, 3410

Immunoglobulins Antibodies with multiple binding functions: induction of single

immunoglobin species by structurally dissimilar haptens, 3269 Cell-surface immunoglobulin of human thymus cells and its

biosynthesis in vitro, 3716 Fab' fragment, three dimensional structure of human

immunoglobulin at 2.8 angstrom resolution, 3305 Lambda-chain production in human lymphoblast-mouse

fibroblast hybrids, 2401 Immunoglobulins, heavy chain of

Messenger RNA coding, isolation of, for mouse heavy-chain immunoglobulin, 1127

Immunoglobulins, light chain of Biologically and chemically pure messenger ribonucleic acid,

prepared with aid of antibodies and immobilized oligothymidine, that codes for mouse immunoglobulin L-chain, 2256


Light-chain gene reiteration of mouse immunoglobulin, estimation

Subject Index 25

of, by DNA-RNA hybridization, 173 Mouse lambda-chain sequences, 2112 Purification of 14S messenger RNA of immunoglobulin light chain

that codes for possible light-chain precursor, 451 Immunoglobulin synthesis


Immunological function Immunological function of lymphocytes fractionated with

antigen-derivatized fibers, 3894 Implantation

Cell-surface glycoproteins of mouse embryos: change before implantation, 1645

Index Author index to volume 70 of Proc. Nat. Acad. Sci. USA, 3937

Indole Pineal indole biosynthesis, control of by changes in sympathetic

tone caused by factors other than environmental lighting, 1704 Indomethacin


Inequality Generalized isoperimetric inequalities, 1005

Infection, intracerebral Prophylaxis and immunization in mice by use of virus-free


Infectivity Infectious deoxyribonucleic acid from herpes simplex virus:

infectivity of double-stranded and single-stranded molecules, 3621

Influenza virus Prophylaxis and immunization in mice by use of virus-free


Influenza virus ribonucleic acid Messenger activity of influenza virion RNA, 2960

Infrared spectroscopy Spin-state correlations in near infrared spectroscopy of

cytochrome c', 1851 Inheritance, Mendelian

Altered chloroplast ribosomal proteins associated with erythromycin-resistant mutants in two genetic systems of Chlamydomonzas reinhardi (correction), 2176

Inheritance, uniparental Altered chloroplast ribosomal proteins associated with


Initiation see also Peptide synthesis, initiation of

Initiation complex Ribosomes crosslinked with dimethylsuberimidate: structural and

functional properties (correction), 1618 Initiation factor


Factor-promoted dissociation of free ribosomes in rabbit reticulocyte lysate system: inhibition and requirement for energy source, 787

Inhibition of reticulocyte peptide-chain initiation by pactamycin: accumulation of inactive ribosomal initiation complexes, 22

Polypeptide-chain initiation, specific inhibitor in Escherichia coli, 2874


Translation of rabbit hemoglobin messenger RNA in vitro with purified and partially purified components from brain or liver of different species, 462

Initiation factor 2 Thiostrepton, effect on recycling of Escherichia coli initiation

factor 2, 1939 Initiation factor 3

Inhibition of cellular protein synthesis by double-stranded RNA: inactivation of initiation factor, 1222

Messenger selection by bacterial ribosomes, 2364 Initiation factor M3

Ribosome dissociation factor from rabbit reticulocytes distinct from initiation factor M3, 2220

Inosine monophosphate pyrophosphorylase see Hypoxanthine phosphoribosyltransferase

Inosine 5'-phosphate dehydrogenase (EC 1.2.1.14) 1-f-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole): new

broad-spectrum antiviral agent, 1174 Inositol


Insulin Adenosine 3':5'-cyclic monophosphate, role in early transport




Guanosine 3':5'-cyclic monophosphate and action of insulin and acetylcholine, 2443

Hepatic glycogen synthesis, regulation during fetal development: roles of hydrocortisone, insulin, and insulin receptors, 3454




Insulin effect on growth pattern and adenylate cyclase activity of BHK fibroblasts, 1388

Insulin, immobilized Affinity binding of intact fat cells and their ghosts to immobilized

insulin, 792 Insulin receptor


Integumental specification hypothesis Acquisition of specificity in cutaneous sensory neurons:

reconsideration of integumental specification hypothesis, 3684 Intelligence

Fertility, IQ, and school achievement (abstract), 3935 Organization of memory, 1478 Variance of Caucasian admixture in Negro populations,

pigmentation variability, and IQ (abstract), 2180 Intercalated particle, membrane

Membrane intercalated particles in human erythrocyte ghosts: sites of preferred passage of water molecules at low temperature, 1339

Interference contrast microscopy Affinity binding of intact fat cells and their ghosts to immobilized

insulin, 792 Interferon

Antiviral effect of interferon covalently bound to Sepharose, 2360 Inhibition of cellular protein synthesis by double-stranded RNA:

inactivation of initiation factor, 1222 Interferon enhances expression of surface antigens on murine

leukemia L 1210 cells, 2785 Interferon: evidence for its glycoprotein nature, 1981 Interferon messenger RNA activity, stabilization by treatment of

cells with metabolic inhibitors and lowering of incubation temperature, 3909

Interferon treatment, effect on cellular messenger RNA, 3815 Interferon uptake in parental and somatic monkey-mouse hybrid

cells, mechanism of, 557 Mouse interferon, purification of, by affinity chromatography on

solid-phase immunoadsorbent, 1037 International scientific cooperation

Talk by Academician Mstislav V. Keldysh, 637 Intersecting storage ring


Invariant theory Unipotent groups in invariant theory, 646

lodination see also Lactoperoxidase iodination Stable solid model for protein sulfenyl iodides, 328

Iodine- 125 Iodine-125-labeled DNA.RNA hybrids in cytological preparations,

1536 Iodine, active

N-Iodosuccinimide reaction with goitrogens: model for active iodine of thyroid gland, 1401

Ion see also specific ions

Ion-diffusion potential Ion-diffusion potentials and electrical rectification across lipid

membranes activated by excitation-induced material (correction), 1284

lonophore Sodium uptake associated with activation of action potential

ionophores of cultured neuroblastoma and muscle cells, 3759 lonophoric material

Sodium-selective ionophoric material from electric organ and kidney membranes, 1191

Ion transport Ion transport across nerve membrane: cooperativity between

channels of large square lattice, 62 Iron pigment

Resonance Raman studies of electronic state of oxygen in hemerythrin, 2582

Iron-sulfur protein Oxidation-reduction potentials of bound iron-sulfur proteins of

photosystem I, 2941 Synthetic analogs of active sites of iron-sulfur proteins: structure

and properties of bis[o-xylyldithiolato-12-sulfidoferrate (III)], an analog of 2Fe-2S proteins, 2429

Isoalloxazine Flavin 1,N6-ethenoadenine dinucleotide: dynamic and static

quenching of fluorescence, 941 Isocitrate


Isopentenylaminopurine, 6-A2- Cytokinins, biosynthesis in cytokinin-autotrophic tobacco callus,

658 Isoperimetric inequality

Generalized isoperimetric inequalities, 1005 Isotropic shifts

Lanthanide ion-induced isotropic shifts and broadening for nuclear magnetic resonance structural analysis of model membranes, 1814

J chain Production of noncovalently bonded pentamer of immunoglobulin

M: relationship to J-chain, 3410

Juvenile hormone Juvenile hormones, biosynthesis in Manduca sexta: labeling

pattern from mevalonate, propionate, and acetate, 2921 Juvenile hormone, new

New natural insect juvenile hormone from Manduca sexta: isolation, structure, and absolute configuration, 1509

Kangaroo rat see Dipodomys ordii

Kasugamycin Ribosomal protein S4 alteration by mutation linked to

kasugamycin-resistance in Escherichia coli, 71 3-Ketoacid coenzyme A-transferase (EC 2.8.3.5)

Alteration in glucose metabolism associated with defect in ketone body metabolism, 210

Ketone aldehyde Amines, interaction with ketone aldehydes and unsaturated

aldehydes, 1030 Ketose-1-phosphate aldolase (EC 4.1.2.7)

Inactive enzyme molecules in aging mice: liver aldolase, 909 Kidney

see also Membrane, kidney Alkaline ribonuclease activity changes during compensatory

renal growth, 169 Kidney bean

see Phaseolus Kinetic control

Polarographic catalytic waves observed with bovine-serum albumin: kinetic or diffusion control, 2020

Polarographic catalytic waves observed with bovine-serum albumin: kinetic or diffusion control (correction), 2710

Kinetics see also Cell kinetics; Chemical kinetics; Reaction kinetics

Klinotaxis Chemotaxis by nematode Caenorhabditis elegans: identification of

attractants and analysis of response by use of mutants, 817

D-Lactate dehydrogenase Reconsititution of D-lactate-dependent transport in membrane


Lactate dehydrogenase (EC 1.1.1.27) Amino acid sequence of dogfish M4 lactate dehydrogenase, 1790 Amino acid sequence of dogfish M4 lactate dehydrogenase

(correction), 2467 Immobilized three-enzyme system: model for microenvironmental

compartmentation in mitochondria, 2534 Structure-function relationships in lactate dehydrogenase, 1968

Lactoperoxidase iodination Structure of some murine RNA tumor viruses studied by

lactoperoxidase iodination, 36 Lake

Surface circulation of lakes and nearly land-locked seas, 93 Lambda chain

Lambda-chain production in human lymphoblast-mouse fibroblast hybrids, 2401

Lambda line Relation between X lines and phase separations, 1241

Lanthanide ion Lanthanide ion-induced isotropic shifts and broadening for

nuclear magnetic resonance structural analysis of model membranes, 1814

Laser see X-ray laser

Laser excitation Stopped-flow apparatus with light-scattering detection and its

application to biochemical reactions, 890 Lattice structure

Ultrastructure of ferritin macromolecules: lattice structure of core crystallites, 3847

L Cell see Mouse L cell

Learning algorithm Organization of memory, 1478

Lectin Concanavalin A derivatives with altered biological activities,

1012 Mitogenic properties of pea lectin and its chemical derivatives,

3650 Receptor mobility and receptor-cytoplasmic interactions in

lymphocytes, 1442 Surface changes in temperature-sensitive simian virus

40-transformed cells, 347 Leghemoglobin

Nicotinic acid as ligand affecting leghemoglobin structure and oxygen reactivity, 564

Lens fiber Cell elongation and microtubule assembly, stimulation of, by

insulin in embryonic chick-lens epithelia, 1195 Lens, ocular

-y-Glutamyl cycle, enzymes in ciliary body and lens, 2211 Lens tissue

Differentiation of lens tissue from progeny of chick retinal pigment cells cultured in vitro: demonstration of switch of cell types in clonal cell culture, 1495

Lesch-Nyhan fibroblast T-antigen gene of simian virus 40, assignment to human




chromosome C-7, 3617 Lesch-Nyhan syndrome


Leucophaea maderae Circadian oscillations, general homeostasis of frequency, 2697

Leucyl-transfer ribonucleic acid synthetase Leucyl-transfer RNA synthetase, temperature sensitive in

mammalian cell mutant, 3094 Leukemia

Attempt to immunize guinea pigs against leukemia by skin scarification with leukemic cell suspensions, 3432

Leukemia-specific DNA sequences in leukocytes of leukemic member of identical twins, 2629

Malignant lymphomas of African children, 15 Modulation of cell behavior in vitro by substratum in fibroblastic

and leukemic mouse cell lines (correction), 284 Leukemia, lymphoblastic

Terminal deoxynucleotidyltransferase in childhood acute lymphoblastic leukemia, 521

Leukemia, myeloblastic Ribonucleic acid tumor virus-like DNA of primate is synthesized

endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood cells, 3219

Leukemia, myeloid Control of normal differentiation of myeloid leukemic cells to

macrophages and granulocytes, 343 Mobility of carbohydrate-containing structures on surface


Leukemia virus Ribonucleic acid components of murine sarcoma and leukemia

viruses, 3536 Leukemia virus, feline


Leukemia virus, Friend 5-Bromo-2'-deoxyuridine, effects on production of globin

messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells, 2956

Friend leukemia virus, host restriction: role of viral outer coat, 2549



Leukemia virus, Moloney Ribonucleic acid from noninfectious virions produced by sarcoma

positive-leukemia negative transformed 3T3 cells, 3002 Structure of some murine RNA tumor viruses studied by

lactoperoxidase iodination, 36 Temperature-dependent expression of transformation by

cold-sensitive mutant of murine sarcoma virus, 2206 Leukemia virus, murine


Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly (vinyladenine), 1204


Radiation leukemia virus, continuous propagation of, on a C57BL mouse-embryo fibroblast line with attenuation of leukemogenic activity, 1250

Ribonucleic acid related to that of murine leukemia virus in Burkitt's tumors and nasopharyngeal carcinomas, 5

Leukemia virus, radiation Radiation leukemia virus, continuous propagation of, on a C57BL

mouse-embryo fibroblast line with attenuation of leukemogenic activity, 1250

Structure of some murine RNA tumor viruses studied by lactoperoxidase iodination, 36

Leukemia virus, rat 5-Bromo-2'-deoxyuridine potentiation of transformation of


Leukemia virus, Rauscher Burkitt's tumors contain particles encapsulating RNA-instructed


Crossreactive antigens on human cells infected with Rauscher leukemia virus and on human acute leukemia cells, 495

Ribonucleic acid-directed deoxyribonucleic acid polymerase and virus-induced leukemia in mice, 1298

Leukemic cell, human Crossreactive antigens on human cells infected with Rauscher

leukemia virus and on human acute leukemia cells, 495 Mutagenic DNA polymerase in human leukemic cells, 245 Nuclear DNA sequences present in human leukemic cells and

absent in normal leukocytes (correction), 627 Rifamycin derivatives, action on RNA polymerase of human

leukemic lymphocytes, 2072 Leukemic mouse cell line

Interferon enhances expression of surface antigens on murine leukemia L 1210 cells, 2785


Subject Index 27

Leukemogenic activity Radiation leukemia virus, continuous propagation of, on a C57BL

mouse-embryo fibroblast line with attenuation of leukemogenic activity, 1250

Leukocyte see also Granulocyte; Blood cell Cytochalasin B: effect on lysosomal enzyme release from human

leukocytes, 844 Infectious Epstein-Barr virus release by transformed marmoset

leukocytes, 190 Lysosomal enzyme, mechanisms of release from human

leukocytes: microtubule assembly and membrane fusion induced by component of complement, 2916


Ligand Cytochrome P-450 ligands, new method of study by linear electric

field-induced shifts in electron paramagnetic resonance, 2979 Ligand binding

Interpretation of binding of carbon monoxide to hemoglobin under photodissociating conditions, 673

Statistical mechanics applied to cooperative ligand binding to proteins, 3914

Light reaction Free radical detection in primary reaction of chloroplast

photosystem II, 294 Light-scattering


Limb-bud cell (cultured) Chondrogenesis in limb-bud cell cultures, control with

bromodeoxyuridine, 2201 Limulus

Inhibition, facilitation of, in compound lateral eye of Limulus, 894 Lindemann scheme

Singular perturbation method, application to reaction kinetics, 1588

Lipid see also Fatty acid; Membrane, lipid; Phospholipid Boundary lipid in membranes, 480

Lipid bilayer Lipid bilayer phase transition: density measurements and theory,

3443 Lipid-bound oligosaccharide

Lipid-bound oligosaccharides that contain mannose, formation and role in glycoprotein synthesis, 3390

Lipid phase Amphiphilic spin labels, orientation and motion in hexagonal lipid

phases, 1406 Lipid-protein interaction

Polypeptide region of bovine prothrombin specific for binding to phospholipids, 1344

Lipolysis Insulin-like activity of concanavalin A and wheat germ agglutinin:

direct interactions with insulin receptors, 485 Lipophilic acid

Growth inhibition and morphological changes caused by lipophilic acids in mammalian cells, 2457

Lipopolysaccharide, bacterial Structure of bacterial lipopolysaccharides, relationship to its

function in mitogenesis and adjuvanticity, 2129 Lipopolysaccharide protein

Lipopolysaccharide protein, isolation and characterization from Escherichia coli, 2572

Lipoprotein 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity,

regulation in human fibroblasts by lipoproteins, 2162 Peptide fragments of apolipoprotein-alanine: chemical synthesis

and biochemical properties, 2124 Primary dysbetalipoproteinemia: predominance of specific

apoprotein species in triglyceride-rich lipoproteins, 2015 Lithium-antamanide complex


Lithium chloride 50S core Chloramphenicol-binding protein, identification in Escherichia

coli ribosomes by partial reconstitution, 2224 Liver

see also Fetal liver G-T-4-C-G(A)- sequence, replacement by G-A-U-C-G- in initiator

transfer RNA of rabbit-liver cytoplasm, 2600 Neutral to alkaline conversion of liver fructose


Lobster see Homarus americanus

Local solvability of Do Higher-order curvature and local solvability of Df, 797

Locomotion Locomotor patterns, development in absence of peripheral sense

organs and muscles, 954 Luciferase


Luciferin Synthesis of biologically active form of Renilla (sea pansy)

luciferin, 120 Lung

Bradykinin and indomethacin, effects on cyclic GMP and cyclic




AMP in lung slices, 3830 Lycopersicon esculentum


Lymphoblastoid cell line Linear association between cellular DNA and Epstein-Barr virus

DNA in human lymphoblastoid cell line, 2888 Lymphocyte

Activated thymus-derived lymphocytes, enumeration by virus plaque assay, 2299


Human lymphotoxin: purification and some properties, 27 Immunoglobulin M, absence in enzymatically or biosynthetically

labeled thymus-derived lymphocytes, 2879 Immunological function of lymphocytes fractionated with

antigen-derivatized fibers, 3894 Immunological tolerance, induction in bone marrow-derived

lymphocytes of IgE antibody class, 2776 Induction of immunoglobulin M synthesis and secretion in bone

marrow-derived lymphocytes by locally concentrated concanavalin A, 416

Induction of lymphocyte transformation by sequential treatment with neuraminidase and galactose oxidase, 1824

Locus determining lymphocyte cell-surface alloantigen in mice: Ly-4, 1108

Neuraminidase-treated lymphocytes, transformation by soybean agglutinin, 2515

Receptor mobility and receptor-cytoplasmic interactions in lymphocytes, 1442

Specificity of antibodies in amphibian larvae possessing small number of lymphocytes, 1898


Thymus-derived cells, synergism between subpopulations mediating proliferative and effector phases of mixed lymphocyte reaction, 2707

Lymphoid cell HL-A variants in cultured human lymphoid cells: isolation and

characterization, 1397 Human complement, activation by human lymphoid cells

sensitized with histocompatibility alloantisera, 3665 Lymphoma

see also Burkitt's lymphoma Cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic

monophosphate and isolation of resistant variants, 76 Deoxyribonucleic acid, unique nuclear sequences in involved

tissues of Hodgkin's and Burkitt's lymphomas, 3810 Malignant lymphoma in cottontop marmosets after inoculation

with Epstein-Barr virus, 2487 Malignant lymphomas of African children, 15 Marek's disease herpesvirus and avian leukosis virus, biological

and biochemical evidence for interaction in vivo, 3175 Purification of Hodgkin's disease tumor-associated antigens, 396 Tumor antigen in tissue cultures derived from patients with

Hodgkin's disease, 1540 Lymphotoxin

Human lymphotoxin, binding to target-cell membranes and its relation to cell-mediated cytodestruction, 3082

Human lymphotoxin: purification and some properties, 27 Lyon hypothesis

Inactivation system of the mammalian X chromosome, 195 Lysosomal enzyme

Cytochalasin B: effect on lysosomal enzyme release from human leukocytes, 844

Fructose 1,6-biphosphatase: role of lysosomal enzymes in modification of catalytic and structural properties, 303


Lysosome Changes in rabbit-liver lysosomes and fructose

1,6-bisphosphatase induced by cold and fasting, 3674 Lytechinus pictus

Cell-free translation of maternal messenger RNA from sea urchin eggs, 2614

Cytoplasmic adenylylation and processing of maternal RNA, 406

Macrocyst formation Mating types and macrocyst formation in Dictyostelium

discoideum, 1828 Macroglobulin

see Waldenstrom macroglobulin Macromolecule

Intervent dilution chromatography: concept for separation of strongly interacting macromolecules, 2424

Ultrastructure of ferritin macromolecules: lattice structure of core crystallites, 3847

Macrophage Control of normal differentiation of myeloid leukemic cells to

macrophages and granulocytes, 343 Cytogenetic engineering in vivo: restoration of biologic


Mobility of carbohydrate-containing structures on surface membrane and normal differentiation of myeloid leukemic

cells to macrophages and granulocytes, 2577 Magnesium chelate complex

Myosin adenosine triphosphate hydrolysis: mechanism involving magnesium chelate complex, 3793

Magnetic moment effect Magnetic moment effects on tests of charge independence in

nucleon-nucleon scattering (abstract), 2178 Magnetic pair


Magnetic relaxation dispersion see Solvent proton magnetic relaxation dispersion

Magnetofluid-dynamic spectrum Magnetofluid-dynamic spectrum and low shear stability, 3277

Maize see Zea mays

Malate dehydrogenase (EC 1.1.1.37) Immobilized three-enzyme system: model for microenvironmental

compartmentation in mitochondria, 2534 Manduca sexta

Juvenile hormones, biosynthesis in Manduca sexta: labeling pattern from mevalonate, propionate, and acetate, 2921

New natural insect juvenile hormone from Manduca sexta: isolation, structure, and absolute configuration, 1509

Mannose Lipid-bound oligosaccharides that contain mannose, formation

and role in glycoprotein synthesis, 3390 Marek's disease herpesvirus


Markov processes Asymptotics of some relativistic Markov processes, 3551

Marmoset, cottontop see Saguinus oedipus

Marxian economics Optimality of profit-including prices under ideal planning, 2109

Mathematics see also Applied mathematics Asymptotic formula for coordinates of zeros of sections of zeta

function, WN(S), near s = 1, 985 Asymptotics of some relativistic Markov processes, 3551 Classes of spatially inhomogeneous pseudodifferential operators,

1500 F-Deformations and F-tractions, 1634 Generalized isoperimetric inequalities, 1005 Higher-order curvature and local solvability of Df, 797 Maximal functions and HP spaces defined by ergodic

transformations, 1761 "Metodo rapido" for finding real quadratic fields of class-number

1, 395 Minimax principles for solution of semilinear gradient operator

equations in Hilbert space, 1519 p-Algebras of arbitrary exponents, 533 Unipotent groups in invariant theory, 646

Mating Chromosomal control of mating activity in Drosophila

pseudoobscura, 459 Mating types and macrocyst formation in Dictyostelium

discoideum, 1828 Synchronous mating in yeast, 1373

Mating, assortative Deviations from Hardy-Weinberg frequencies caused by

assortative mating in hybrid populations, 732 Deviations from Hardy-Weinberg frequencies caused by

assortative mating in hybrid populations (correction), 1903 Mathematical models for assortative mating in American Negro


Measles 1-f-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole): new

broad-spectrum antiviral agent, 1174 Oligoclonal immunoglobulin G antibody response in central

nervous system to different measles virus antigens in subacute sclerosing panencephalitis, 1060

Mediterranean anemia see Thalassemia

Meiosis Amplified ribosomal DNA release from chromomeres of Acheta,

80 Chromosome replication during meiosis: identification of gene

functions required for premeiotic DNA synthesis, 3087 Melampodin



Melatonin Pineal indole biosynthesis, control of by changes in sympathetic

tone caused by factors other than environmental lighting, 1704 Membrane, bacterial

Association of rIIA protein with bacterial membrane, 1468 Detergent hydrophobic lipophilic balance (HLB) number, relation

to solubilization and stabilization of D-alanine carboxypeptidase from Bacillus subtilis membranes, 2997

Membrane-binding protein Biochemical basis of resistance of sugarcane to eyespot disease,

1693




Membrane, bladder see Bladder membrane, toad

Membrane, cell Active transport model of sodium and potassium ions as mediated

by tetrameric enzyme, 275 Boundary lipid in membranes, 480 Cell contact-dependent increase in membrane


Coat protein of bacteriophage M13 virion participates in membrane-oriented synthesis of DNA, 205

Contraction of isolated smooth-muscle cells: structural changes, 641

Human lymphotoxin, binding to target-cell membranes and its relation to cell-mediated cytodestruction, 3082

Lipopolysaccharide protein, isolation and characterization from Escherichia coli, 2572



New complement-mediated cytolytic mechanism: Cl-bypass activation pathway, 649

Membrane conductance Ion-diffusion potentials and electrical rectification across lipid


Membrane electrode Equilibrium potentials of membrane electrodes, 1909

Membrane fusion Lysosomal enzyme, mechanisms of release from human

leukocytes: microtubule assembly and membrane fusion induced by component of complement, 2916

Phospholipid vesicles, fusion of, with viable Acholeplasma laidlawii, 1238

Membrane, kidney see also Kidney Sodium-selective ionophoric material from electric organ and

kidney membranes, 1191 Membrane, lipid

see also Membrane, phospholipid Ion-diffusion potentials and electrical rectification across lipid


Membrane lipids, lateral phase separations and mechanism of sugar transport in Escherichia coli, 2271


Membrane, lipoprotein Membrane lipoprotein activation of proteolytic system:

mechanism of action of tissue factor, 310 Membrane, mitochondrial


Mitochondrial membrane system assembly: purification of mitochondrial product of ATPase, 3155

Membrane, model Lanthanide ion-induced isotropic shifts and broadening for

nuclear magnetic resonance structural analysis of model membranes, 1814

Membrane, nerve Ion transport across nerve membrane: cooperativity between

channels of large square lattice, 62 Pressure effect on membrane action of nerve-blocking spin label,

3179 Membrane-nucleic acid interaction

Membrane binding of replicative RNA of bacteriophage MS2, two classes, 2381

Membrane, optical activity Membrane optical activity: some facts and fallacies, 3235

Membrane permeability Phosphorylation of specific protein regulation in toad-bladder



Membrane phospholipid Metabolism of membrane phospholipids and its relation to novel

class of oligosaccharides in Escherichia coli, 1368 Membrane, photoreceptor

New photoreceptor membrane, functions of, 2853 Photoreceptors, regulation of cyclic nucleotide concentrations:


Membrane, plant Phytochrome, binding properties to membrane fraction in vitro,

3861 Membrane, plasma

Adenosine 3':5'-cyclic monophosphate-dependent protein kinase, studies on orientation in human erythrocyte membranes, 3735

Affinity binding of intact fat cells and their ghosts to immobilized insulin, 792


Erythrocyte ghost ul trastructure, preservation achieved by various fixatives, 3060

Plasma membranes from cultured muscle cells: isolation

Subject Index 29

procedure and separation of putative plasma-membrane marker enzymes, 3195

Plasma membranes, specific recognition by embryonic cells, 2794 Membrane, postsynaptic

Hebb's postulate of learning: physiological mechanism, 997 Membrane potential

Galactoside, proton-coupled accumulation in Streptococcus lactis 7962, 2866

Membrane protein Coupling between bacteriochlorophyll and membrane protein

synthesis in Rhodopseudomonas spheroids, 799 Relatedness among contractile and membrane proteins: evidence

for evolution from common ancestral genes, 3230 Reticulocyte membrane proteins, biosynthesis by membrane-free

polyribosomes, 1526 Membrane receptor

Concanavalin A derivatives with altered biological activities, 1012

Neuraminidase-treated lymphocytes, transformation by soybean agglutinin, 2515


Membrane sealing Membrane sealing in frog skeletal-muscle fibers, 982 Membrane sealing in frog skeletal-muscle fibers (addendum),

3007 Membrane structure

Cell envelope and shape of Escherichia coli K12, 2033 Membrane intercalated particles in human erythrocyte ghosts:


Membrane structure, changes associated with cell contact, 3631 Membrane, surface

Electron spin resonance studies of spin-labeled mammalian cells by detection of surface membrane signals, 66

Glycopeptides from surface membranes of neuroblastoma cells, 1682

Mobility of carbohydrate-containing structures on surface membrane and normal differentiation of myeloid leukemic cells to macrophages and granulocytes, 2577

Nerve growth factor, interaction with surface membranes: biological competence of insolubilized nerve growth factor, 2931

Membrane, synaptic Strychnine binding associated with glycine receptors of central

nervous system, 2832 Membrane, thylakoid

Attachment of chloroplast polysomes to thylakoid membranes in Chlamydomonas reinhardtii, 1554

Membrane vesicle Anaerobic transport in Escherichia coli membrane vesicles, 3376 Dansyl-galactoside: fluorescent probe of active transport in

bacterial membrane vesicles, 2722 Electrical potential, role in coupling of metabolic energy to active

transport by membrane vesicles of Escherichia coli, 1804 Reconsititution of D-lactate-dependent transport in membrane


Memory Organization of memory, 1478

Mengo virus In vitro translation of oogenetic messenger RNA of sea urchin

eggs and picornavirus RNA with cell-free system from sarcoma 180, 3287

2-Mercaptoethylamine Production of noncovalently bonded pentamer of immunoglobulin

M: relationship to J-chain, 3410 Mercurinitrophenol

Substrate binding to active creatine kinase with thiol-bound mercurinitrophenol chromophoric probe, 2858

Mercury (element) Cesium sulfate gradients that contain both Hg2+ and Ag+ effect


Synthesis and enzymatic polymerization of nucleotides containing mercury: potential tools for nucleic acid sequencing, 2238

Merogon Polyadenylation of maternal RNA of sea urchin eggs after

fertilization, 2345 Meromyosin, heavy


Meson physics facility Clinton P. Anderson Meson Physics Facility (LAMPF) (N.A.S.

Symposium: new accelerators), 603 Metabolism

see also Carbohydrate catabolism; Glucose metabolism; Purine metabolism

Dynamics of metabolism of normal and virus-transformed chick cells in culture, 2951

Metalloenzyme Catalytic mechanism of carbonic anhydrase, 2505 Cobalt bovine procarboxypeptidase A spectrum: index of catalytic

function (correction), 284 Molecular mechanism for action of molybdenum in enzymes:

coupled proton and electron transfer, 988 Metalloprotein

Carbon-13 enriched a-methyl-D-glucopyranoside binding to concanavalin A as studied by carbon magnetic resonance, 1007




Methadone Methadone plasma level: sustained by reservoir of drug in tissue,

10 Methemoglobinemia

Structure of hemoglobin M Boston, variant with five-coordinated ferric heme, 3870

Methionine 5-Methyltetrahydrofolate :homocysteine methyltransferase

activity, regulation by methionine, vitamin B12, and folate in cultured baby hamster kidney cells, 2585

Methionine, amino-terminal Delayed removal of amino-terminal methionine from nascent

globin chains in sickle-cell anemia reticulocytes, 2059 Methodology



Cytochrome P-450 ligands, new method of study by linear electric field-induced shifts in electron paramagnetic resonance, 2979

Deoxyribonucleic acid replication, microfluorometric detection in human metaphase chromosomes, 3395

Fingerprinting techniques, application to iodinated nucleic acids, 3260

General method of gene isolation, 1697 Genetic method for determining order of events in biological

pathway, 2046 Guanosine 3':5'-cyclic monophosphate, new enzymatic assay and

its application to ductus deferens of rat, 1721 Improved bacterial test system for detection and classification of

mutagens and carcinogens, 782 Intervent dilution chromatography: concept for separation of

strongly interacting macromolecules, 2424 Iodinated RNA, use for gene localization, 1860 Magnetic suspension osmometer, 3785 Molecule microscope: new instrument for biological and

biomedical research, 2781 Nonheuristic computer determination of molecular structure


Phenylethanolamine in brain and other tissues: demonstration and distribution, 769

Pyrimidine dimers, method for detecting in DNA of bacteria irradiated with low doses of ultraviolet light, 2753

Quantitative assay for intercellular adhesion, 1569 Ribonucleic acid polymerases of maize: purification and

molecular structure of DNA-dependent RNA polymerase II, 2386



Thalassemia syndromes, quantitative deficiency of chain specific messenger ribonucleic acids, 1809


N-Methylation Native ribonucleoprotein complex from Escherichia coli

ribosomes, 665 3-Methylcholanthrene

5-Bromo-2'-deoxyuridine potentiation of transformation of rat-embryo cells induced in vitro by 3-methylcholanthrene: induction of rat leukemia virus gs antigen in transformed cells, 2415

3-Methylgalactoside transport f-Methylgalactoside transport system and galactose-binding

protein, regulation by cell cycle of Escherichia coli, 1481 3-O-Methylglucose


a-Methyl-D-glycopyranoside Carbon-13 enriched a-methyl-D-glucopyranoside binding to

concanavalin A as studied by carbon magnetic resonance, 1007 5-Methyltetrahydrofolate homocysteine methyltransferase

5-Methyltetrahydrofolate :homocysteine methyltransferase activity, regulation by methionine, vitamin B12, and folate in cultured baby hamster kidney cells, 2585

Met-tRNAf see Ribonucleic acid, transfer, methionyl (formylatable)

Mevalonate Juvenile hormones, biosynthesis in Manduca sexta: labeling

pattern from mevalonate, propionate, and acetate, 2921 Mexican-American

How biased are culture-loaded tests? (abstract), 3935 Micelle

Amphiphilic spin labels, orientation and motion in hexagonal lipid phases, 1406

Cholesterol, self-association in aqueous solution, 2313 Microenvironment

Immobilized three-enzyme system: model for microenvironmental compartmentation in mitochondria, 2534

f2-Microglobulin Human f2-microglobulin, multiple common properties and

common portion fragment derived from HL-A antigen molecules, 2863

Microsome Enzyme assay in microsomes below zero degrees, 2633

Microsurgery Microsurgically fused human somatic cell hybrids: analysis and

cloning, 3382 Microtubule

a- and f-Tublin, isolation and partial characterization from outer doublets of sea-urchin sperm and microtubules of chick-embryo brain, 3594


Cytochalasin B: effect on lysosomal enzyme release from human leukocytes, 844


Microtubule assembly in the absence of added nucleotides, 765 Microtubule assembly in the absence of added nucleotides

(correction), 1903 Pleiotypic control by cyclic AMP: interaction with cyclic GMP

and possible role of microtubules, 1659 Milk, human

Oncornaviruses in human milk: production of cores, 1976 Milk, mouse

Viral DNA polymerase in mouse milk: characterization and separation, 2117

Minimax principle Minimax principles for solution of semilinear gradient operator

equations in Hilbert space, 1519 Mitochondrial genome

see Genome, mitochondrial Mitochondrion

see also Protein synthesis, mitochondrial Can non-Mendelian mutation affect both chloroplast and

mitochondrial ribosomes? 3463 Ca2+ transport by mitochondria from L1210 mouse ascites tumor

cells, 1744 Glutamate and isocitrate, inhibition of oxidation in liver

mitochondria at specific NADP+-reducing site, 3450 Immobilized three-enzyme system: model for microenvironmental

compartmentation in mitochondria, 2534 Mitochondria, autonomy of, in Saccharomyces cerevisiae in

production of messenger RNA, 111 Mitochondrial adenosine diphosphate uptake, stimulation by

thyroid hormones, 98 Mitochondrial membrane system assembly: purification of

mitochondrial product of ATPase, 3155 Mitochondrial protein synthesis: RNA with properties of

eukaryotic messenger RNA, 350 Oxidative phosphorylation, concept for energy coupling based on

molecular explanation of oxygen exchange reactions, 2837 Ribonucleotides in mature closed-circular mitochondrial DNA,

3339 Sequence homologies among bacterial and mitochondrial

superoxide dismutases, 3725 Temperature-dependent formation of dimers and oligomers of


Transductional and structural principles of mitochondrial transducing unit, 904

Virus-like particles in extranuclear mutant of Neurospora crassa, 1574

Mitogenesis Mitogenic properties of pea lectin and its chemical derivatives,

3650 Structure of bacterial lipopolysaccharides, relationship to its

function in mitogenesis and adjuvanticity, 2129 Mitogen stimulation


Mitomycin C Colicin K of Escherichia coli K235, 854

Mixed lymphocyte reaction Thymus-derived cells, synergism between subpopulations

mediating proliferative and effector phases of mixed lymphocyte reaction, 2707

M-line protein Protein that binds specifically to M-line of skeletal muscle is

identified as muscle form of creatinine kinase, 702 Model, allosteric enzyme

Spatiotemporal organization, patterns in allosteric enzyme model, 3255

Model for sliding filament Muscular contraction, theory extended to groups of actin sites,

2732 Molecular orbital theory

Energy of substituted ethanes: asymmetry orbitals, 531 Molecular orientation

Hemoglobin S, structure and optical determination of molecular orientation in sickled erythrocytes, 3604

Molecular structure Nonheuristic computer determination of molecular structure


Molecular weight determination Dopamine-,-hydroxylase: tetrameric glycoprotein, 2253 Magnetic suspension osmometer, 3785

Molecule microscope Molecule microscope: new instrument for biological and

biomedical research, 2781




Molecule, moment of vector of Moments of end-to-end vector of chain molecule, its persistence

and distribution, 1819 Molybdenum




Moniliasis HL-A-linked human immune-response genes, 2157

Monogenic strain Self-fertilization and genetic population structure in colonizing

land snail, 1186 Moon

Origin of surface features of moon (abstract), 2179 Review of recent scientific findings on the nature of the moon

(Scientific Program of National Academy of Sciences USA, Autumn 1973 Meeting), 3934

Moose Sodium dynamics in northern ecosysten, 2745

Morphogenesis Bone morphogenesis in implants of insoluble bone gelatin, 3511 Genetic method for determining order of events in biological

pathway, 2046 Head morphogenesis of bacteriophage T4: isolation, partial


Morphogenesis, sexual Mutational analysis of regulatory gene for morphogenesis in

Schizophyllum, 1427 Morphogenetic mutant

Genetic control of development in Volvox: isolation and characterization of morphogenetic mutants, 1335

Mouse L cell Protein of molecular weight 78,000 bound to polyadenylate region

of eukaryotic messenger RNAs, 924 Mouse 1R cell


Mouse sarcoma virus see Murine sarcoma virus

Mucopolysaccharide Defect in Hunter syndrome: deficiency of sulfoiduronate

sulfatase, 2134 Mucopolysaccharides, production by normal and transformed

cells, 54 Multicellular life, origin of

Ecological theory for sudden origin of multicellular life in late Precambrian, 1486

Multiple trial learning Automimicry, theoretical investigations: multiple trial learning

and palatability spectrum, 2261 Murein

Cell envelope and shape of Escherichia coli K12, 2033 Murine mammary tumor virus

see Tumor virus, murine mammary Murine sarcoma-leukemia virus complex

Virus-specific messenger RNA and nascent polypeptides in polyribosomes of cells replicating murine sarcoma-leukemia viruses, 2064

Murine sarcoma virus Cell-surface antigen associated with murine sarcoma virus by

immunoelectronmicroscopy, 742 Contact inhibition of movement in cultures of transformed cells,

2011 Deoxyglucose transport, growth and density-dependent inhibition

in Balb 3T3 cells and its absence in cells transformed by murine sarcoma virus, 2374

Ribonucleic acid components of murine sarcoma and leukemia viruses, 3536

Ribonucleic acid from noninfectious virions produced by sarcoma positive-leukemia negative transformed 3T3 cells, 3002

Sugar effects on murine sarcoma virus transformation, 1364 Temperature-dependent expression of transformation by

cold-sensitive mutant of murine sarcoma virus, 2206 Muscle

Locomotor patterns, development in absence of peripheral sense organs and muscles, 954

Muscle cell, cardiac Immobilized catecholamine and cocaine, effects of, on

contractility of cardiac muscle, 1214 Myocardial myosin, regulatory properties, 3205

Muscle cell, skeletal Acetylcholine receptor and ion conductance modulator sites at

murine neuromuscular junction: evidence from specific toxin reactions, 949

Acetylcholine receptor clusters on cultured muscle cells, 270 Actin, complete amino acid sequence in rabbit skeletal muscle,

2687 Actin in dividing cells: contractile ring filaments bind heavy

meromyosin, 1688 Membrane sealing in frog skeletal-muscle fibers, 982 Membrane sealing in frog skeletal-muscle fibers (addendum),

3007 Myosin adenosine triphosphate hydrolysis: mechanism involving

magnesium chelate complex, 3793

Subject Index 31

Plasma membranes from cultured muscle cells: isolation procedure and separation of putative plasma-membrane marker enzymes, 3195

Protein that binds specifically to M-line of skeletal muscle is identified as muscle form of creatinine kinase, 702


Snake a-neurotoxin, effects on development of innervated skeletal muscles in chick embryo, 1708

Sodium uptake associated with activation of action potential ionophores of cultured neuroblastoma and muscle cells, 3759

Temperature-sensitive variants of established myoblast line, 425 Muscle cell, smooth


Contraction of isolated smooth-muscle cells: structural changes, 641

Muscle contraction Contraction of isolated smooth-muscle cells: structural changes,

641 Immobilized catecholamine and cocaine, effects of, on

contractility of cardiac muscle, 1214 Muscular contraction, theory extended to groups of actin sites,

2732 Muscle, crustacean

Synaptic differentiation in regenerating crab-limb muscle, 822 Muscular dystrophy

see Myotonic muscular dystrophy Mus species

Relatedness of mouse satellite deoxyribonucleic acid to deoxyribonucleic acid of various Mus species, 3546

Mutagen Carcinogens are mutagens: simple test system combining liver

homogenates for activation and bacteria for detection, 2281 Mutagenesis



Mutagenic DNA polymerase in human leukemic cells, 245 Mutagenesis, chemical



Mutant of avian sarcoma virus Avian sarcoma virus, isolation of defective mutant, 3493

Mutant of Chinese hamster cell Mutations affecting structure of hypoxanthine: guanine

phosphoribosyltransferase in cultured Chinese hamster cells, 320

Mutant of Chinese hamster ovary cell Chick chromosomes, identification in cell hybrids formed between


Leucyl-transfer RNA synthetase, temperature sensitive in mammalian cell mutant, 3094

Mutant of Chlamydomonas reinhardtii Can non-Mendelian mutation affect both chloroplast and

mitochondrial ribosomes? 3463 Mutant of Dictyostelium discoideum

Mutations affecting N-acetylglucosaminidase in Dictyostelium discoideum, 3356

Mutant of Drosophila Neurophysiology of flight in wild-type and mutant of Drosophila,

1050 Mutant of Escherichia coli

Bacteriophage kX-174, replication in mutant of Escherichia coli defective in dnaE gene, 1757

Macromolecular biosynthesis, regulation in mutant of Escherichia coli defective in membrane phospholipid biosynthesis, 385

Mutant of Escherichia coli with new, highly efficient promoter for lactose operon, 3693

Mutants of Escherichia coli thermosensitive for synthesis of transfer RNA, 2091

Nucleotide sequence of lactose messenger ribonucleic acid transcribed from UV5 promotor mutant of Escherichia coli, 3585

Reconsititution of D-lactate-dependent transport in membrane vesicles from D-lactate dehydrogenase mutant of Escherichia coli, 1917

Ribosomal protein S4 alteration by mutation linked to kasugamycin-resistance in Escherichia coli, 71


Mutant of Euglena Cytoplasmic regulatory mutant of Euglena: constitutivity for

light-inducible chloroplast transfer RNAs, 1749 Mutant of mammalian cells

Bromodeoxyuridine dependence: new mutation in mammalian cells, 138

Mutant of murine sarcoma virus Temperature-dependent expression of transformation by

cold-sensitive mutant of murine sarcoma virus, 2206 Mutant of nematode

Chemotaxis by nematode Caenorhabditis elegans: identification of attractants and analysis of response by use of mutants, 817




Mutant of Neurospora crassa Virus-like particles in extranuclear mutant of Neurospora crassa,

1574 Mutant of Rous sarcoma virus

Temperature-dependent formation of dimers and oligomers of mitochondrial DNA in cells transformed by thermosensitive mutant of Rous sarcoma virus, 3739

Mutant of Saccharomyces cerevisiae Population analysis of deinduction kinetics of galactose long-term

adaptation mutants of yeast, 919 Mutant of Schizophyllum

Mutational analysis of regulatory gene for morphogenesis in Schizophyllum, 1427

Mutant of T4 bacteriophage Head morphogenesis of bacteriophage T4: isolation, partial


Mutant of 3T3 cells Mutant of 3T3 cells with cyclic AMP metabolism sensitive to

temperature change, 2906 Mutant of Volvox


Mutation, frameshift Carcinogens are mutagens: simple test system combining liver

homogenates for activation and bacteria for detection, 2281 Improved bacterial test system for detection and classification of

mutagens and carcinogens, 782 Improved bacterial test system for detection and classification of

mutagens and carcinogens (correction), 1903 Mutation frequency

"Private" genetic variants and frequency of mutation among South American Indians, 3311

Mutation, non-Mendelian Can non-Mendelian mutation affect both chloroplast and

mitochondrial ribosomes? 3463 Mycobacterium phlei

Complex formation between mycobacterial polysaccharides and fatty acyl-CoA derivatives, 1146

Mycoplasma Phospholipid vesicles, fusion of, with viable Acholeplasma

laidlawii, 1238 Mycoplasma gallisepticum


Tropism of Mycoplasma gallisepticum for arterial walls, 1545 Mycoplasma neurolyticum


Myelin Collagen and procollagen production by clonal line of Schwann

cells, 1943 Myeloma

Biologically and chemically pure messenger ribonucleic acid, prepared with aid of antibodies and immobilized oligothymidine, that codes for mouse immunoglobulin L-chain, 2256

Myeloma protein Fab' fragment, three dimensional structure of human.

immunoglobulin at 2.8 angstrom resolution, 3305 Immunochemical analysis of cross-reacting idiotypes of mouse




Myoblast Temperature-sensitive variants of established myoblast line, 425

Myofilament orientation Contraction of isolated smooth-muscle cells: structural changes,

641 Myoglobin

Myoglobin, synthesis of active site, 2647 Myosin of muscle



Myosin of myocardium Myocardial myosin, regulatory properties, 3205

Myosin of platelets Phosphorylation of human platelet myosin, 3115

Myotonic muscular dystrophy Protein kinase activity in erythrocyte ghosts of patients with

myotonic muscular dystrophy, 1855

Nalidixic acid Nalidixic acid, effect on DNA replication by toluene-treated

Escherichia coli, 1955 Naloxone

Opiate-receptor binding, properties in rat brain, 2243 Narcotic

see also Cocaine; Heroin Opiate-receptor binding, properties in rat brain, 2243 Stereospecific binding of potent narcotic analgesic [3H]etorphine

to rat-brain homogenate, 1947

National Academy of Sciences of USSR Talk by Academician Mstislav V. Keldysh, 637

National Academy of Sciences USA, council National Academy of Sciences USA, Officers, Council, Sections,

and Members, 3009 National Academy of Sciences USA, members

National Academy of Sciences USA, Officers, Council, Sections, and Members, 3009

National Academy of Sciences USA, officers National Academy of Sciences USA, Officers, Council, Sections,

and Members, 3009 National Academy of Sciences USA, Scientific Programs

Autumn Meeting, October, 1972, 1620 Annual Meeting, April, 1973 (Copernican Symposium: The Nature

of Scientific Discovery), 2181 Autumn Meeting, October, 1973 (From Knowledge to Action:

Science and Its Uses and Review of Recent Scientific Findings on the Nature of the Moon), 3933

National Academy of Sciences USA, sections National Academy of Sciences USA, Officers, Council, Sections,

and Members, 3009 National Academy of Sciences USA Symposia (Autumn meeting,

1972) CERN intersecting storage rings (ISR) (N.A.S. Symposium: new

accelerators), 619 Clinton P. Anderson Meson Physics Facility (LAMPF) (N.A.S.

Symposium: new accelerators), 603 Colliding beams versus beams on stationary targets: competing

tools (N.A.S. Symposium: new accelerators), 611 Competition among plants (N.A.S. Symposium: plant growth

regulation), 585 Ethylene in plant growth (N.A.S. Symposium: plant growth

regulation), 591 Plant productivity and control of photorespiration (N.A.S.

symposium: plant growth regulation), 579 Protoplasts, use for genetic research (N.A.S. Symposium: plant

growth regulation), 598 National Academy of Sciences USA, Abstracts (Annual meeting,

1973) Electronic biology (abstract), 2180 Heliomagnetic-geomagnetic modulation of radiocarbon production

in earth's atmosphere (abstract), 2178 Herpes simplex and genitalis virus nonvirion antigens: use for


Is the inner core liquid after all? (abstract), 2178 Magnetic moment effects on tests of charge independence in

nucleon-nucleon scattering (abstract), 2178 Mathematical models for assortative mating in American Negro



Origin of surface features of moon (abstract), 2179 Quasars as events in galaxy nuclei (abstract), 2179 Recommended daily allowances for vitamin C (ascorbic acid)

(abstract), 1619 Variance of Caucasian admixture in Negro populations,

pigmentation variability, and IQ (abstract), 2180 National Academy of Sciences USA, Abstracts (Autumn meeting,

1973) Confirmation of Negro economic gains on whites and


Fertility, IQ, and school achievement (abstract), 3935 How biased are culture-loaded tests? (abstract), 3935 Wax in coral mucus feeds tropical reef fishes (abstract), 3935

Natural selection Frequency-dependent natural selection model for evolution of

social cooperation networks, 187 Genic variability and strategies of adaptation in animals, 1875

Negro-Caucasian Confirmation of Negro economic gains on whites and




How biased are culture-loaded tests? (abstract), 3935 Mathematical models for assortative mating in American Negro


Variance of Caucasian admixture in Negro populations, pigmentation variability, and IQ (abstract), 2180

Nematode Chemotaxis by nematode Caenorhabditis elegans: identification of

attractants and analysis of response by use of mutants, 817 Countercurrent separation: new method for studying behavior of

small aquatic organisms, 1349 Nephroblastoma, human

Tumor-associated antigen in human nephroblastomas, 2051 Nerve, basic excitation unit of

Integral interpretation of nerve excitability, 727 Nerve, dorsal root ganglia

(3 Nerve growth factor receptor of avian dorsal root ganglia, properties of, 3884

Nerve excitability Integral interpretation of nerve excitability, 727




Nerve growth factor Nerve growth factor and cyclic AMP, mechanism of action on

neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation, 2448

Nerve growth factor, interaction with surface membranes: biological competence of insolubilized nerve growth factor, 2931

Nerve growth factor receptor, binding in sympathetic ganglia, 2519

( Nerve growth factor receptor of avian dorsal root ganglia, properties of, 3884

Nerve, head ganglia of squid Choline acetyltransferase of squid-head ganglia, purification, 3749

Nerve, sciatic Differential transport of protein in axons: comparison between

sciatic nerve and dorsal columns of cats, 1521 Nerve, squid axon membrane

Relaxation spectra of potassium channel noise from squid axon membranes, 876

Neuraminidase (EC 3.2.1.18) Induction of lymphocyte transformation by sequential treatment

with neuraminidase and galactose oxidase, 1824 Neuraminidase-treated lymphocytes, transformation by soybean

agglutinin, 2515 Neurinoma, peripheral

Collagen and procollagen production by clonal line of Schwann cells, 1943

Neurite Nerve growth factor and cyclic AMP, mechanism of action on

neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation, 2448

Neuroblastoma cell Acetylcholine receptors, regulation in relation to


acetylcholinesterase in neuroblastoma cells (correction), 3932 Adenosine-mediated elevation of cyclic 3':5'-adenosine

monophosphate concentrations in cultured mouse neuroblastoma cells, 3099


Glycopeptides from surface membranes of neuroblastoma cells, 1682


Sodium uptake associated with activation of action potential ionophores of cultured neuroblastoma and muscle cells, 3759

Neuromuscular junction Acetylcholine receptor and ion conductance modulator sites at



Neuromuscular transmission Ruthenium Red, inhibitory action on neuromuscular

transmission, 3613 Neuron

Intrasomatic injection of radioactive precursors for studying transmitter synthesis in identified neurons of Aplysia californica, 3371

Neuronal connections in isogenic organisms: optic system of Daphnia magna, 57

Neuronal connections in isogenic organisms: cellular interactions in development of optic lamina of Daphnia, 433

Synaptic differentiation in regenerating crab-limb muscle, 822 Neuronal-glial interaction


Neuronal migration Weaver mutant mouse cerebellum: defective neuronal migration

secondary to abnormality of Bergmann glia, 240 Neuronal network


Neuronal response, auditory Auditory neuronal responses, development in avian embryos,

1795 Neuronal specificity

Adhesive recognition and retinotectal specificity, 2482 Neuronal connections in isogenic organisms: optic system of

Daphnia magna, 57 Neuronal connections in isogenic organisms: cellular interactions

in development of optic lamina of Daphnia, 433 Positional information in retinal ganglion cells of Xenopus: assays

for analysis of unspecified state, 507 Neuron, cutaneous sensory

Acquisition of specificity in cutaneous sensory neurons: reconsideration of integumental specification hypothesis, 3684

Neuron, motor Locomotor patterns, development in absence of peripheral sense

organs and muscles, 954 Neurophysiology of flight in wild-type and mutant of Drosophila,

1050 Neuron, receptor

Presynaptic inhibition at inhibitory nerve terminals: new synapse in crayfish stretch receptor, 2462

Neurophysiology Neurophysiology of flight in wild-type and mutant of Drosophila,

1050

Subject Index 33

Neuropsychology Neuropsychological studies in the USSR: a review (part I), 959 Neuropsychological studies in the USSR: a review (part II), 1278

Neurospora Genetically related protein variants specifically associated with

fruiting body maturation in Neurospora, 1891 Non-Mendelian inheritance of DNA-induced inositol independence

in Neurospora, 3875 Virus-like particles in extranuclear mutant of Neurospora crassa,

1574 a-Neurotoxin


Snake a-neurotoxin, effects on development of innervated skeletal muscles in chick embryo, 1708

Neurotransmitter Acetylcholine biosynthesis in turtle photoreceptors (correction),

284 Neutron diffraction



Neutropenia see Congenital neutropenia

Newcastle disease virus Messenger RNAs of Newcastle disease virus by gel

electrophoresis, separation, 2544 Mouse interferon, purification of, by affinity chromatography on

solid-phase immunoadsorbent, 1037 New Zealand Black mouse

Chromosomal abnormalities in spleens of New Zealand Black mice: strain characterized by autoimmunity and malignancy, 1094

Thymocytes from NZB mice of different ages, alteration in DNA synthetic response, 3769

N gene Anthranilate synthetase synthesis, regulation in vitro by N-gene

protein of phage lambda, 1078 Regulation of expression of N gene of bacteriophage lambda, 421

Niche theory Global models of growth and competition, 3590

Nickel Ground states of cobalt(II) and nickel(II) carboxypeptidase A, 161

Nickel acetylacetonate Nuclear magnetic resonance shift reagents: evidence for different


Nicotina tabacum 8-Bromoadenosine 3':5'-cyclic monophosphate as promoter of cell

division in excised tobacco pith parenchyma tissue, 447 Cytokinins, biosynthesis in cytokinin-autotrophic tobacco callus,

658 Temperature-sensitive lethality in Nicotiana tobacum L., 108 Tobacco pith cells, habituation for factors promoting cell division

is heritable and potentially reversible, 2660 Nicotinamide-adenine dinucleotide phosphate

Conformations of diphosphopyridine coenzymes upon binding to dehydrogenases, 1593

Covalent enzyme-substrate bond activation by noncovalent interaction with an effector, 2077

Nicotinamide-adenine dinucleotide phosphate Glutamate and isocitrate, inhibition of oxidation in liver

mitochondria at specific NADP+-reducing site, 3450 Nicotinamide-adenine dinucleotide glycohydrolase (EC 3.2.2.5)


Nicotinamide-adenine dinucleotide phosphate glycohydrolase (EC 3.2.2.6)


Nicotinamide-adenine dinucleotide (reduced) -methemoglobin diaphorase


Nicotinic acid Nicotinic acid as ligand affecting leghemoglobin structure and

oxygen reactivity, 564 Nitrate reductase


Nitric oxide Magnetic dipole-dipole coupled Cu(II) pairs in nitric oxide-treated


Nitrogenase Differentiation in Nostoc muscorum: nitrogenase is synthesized in

heterocysts, 2727 Electron paramagnetic resonance of nitrogenase and nitrogenase


Molecular mechanism for action of molybdenum in enzymes:




coupled proton and electron transfer, 988 Reduction of acetylene and hydrazine with

molybdenum-glutathione complex, 339 Nitrosamine

Malignant transformation of BHK21 clone 13 cells in vitro by nitrosamines: conditional state, 46

Noise see also Potassium channel noise

Noise-induced deafness Continuous noise, effects on avian hearing and vocal

development, 1393 Nostoc muscorum

Differentiation in Nostoc muscorum: nitrogenase is synthesized in heterocysts, 2727

Novikoff hepatoma Nucleolar proteins of normal rat liver, comparison with Novikoff


Nuclear binding Nuclear binding of steroid receptors: comparison in intact cells

and cell-free systems, 3415 Nuclear magnetic resonance


Conformation of charged and uncharged tRNAPhe, 2193 Determination of secondary and tertiary structural features of

transfer RNA molecules in solution by nuclear magnetic resonance, 2042

Helix-coil transition for poly(L-alanine) as measured by nuclear magnetic resonance, 331

Lanthanide ion-induced isotropic shifts and broadening for nuclear magnetic resonance structural analysis of model membranes, 1814

Measurement of pK values of alkaline Bohr group in human hemoglobin, 1246

Nuclear magnetic resonance study of thermal denaturation of ribonuclease A: implications for multistate behavior at low pH, 914




Proton magnetic resonance study of peptide conformation: effect of trifluoroethanol on oxytocin and 8-lysine-vasopressin, 1199


Watson-Crick base pairs, nuclear magnetic resonance study of hydrogen-bonded ring protons, 2899

Y base, effect of removal on conformation of yeast tRNAPe, 3843

Nuclear magnetic resonance, carbon-13 Carbon dioxide and bicarbonate interaction with human

hemoglobin preparations, 1414 Carbon-13 enriched a-methyl-D-glucopyranoside binding to

concanavalin A as studied by carbon magnetic resonance, 1007 Carbon-13 nuclear magnetic resonance spectra of prostaglandins

and some prostaglandin analogs, 1579 Conformational studies of oxytocin, lysine vasopressin, arginine

vasopressin, and arginine vasotocin by carbon-13 nuclear magnetic resonance spectroscopy, 2086


Guanosine 5'-diphosphate, 3'-diphosphate: assignment of structure by 13C nuclear magnetic resonance spectroscopy, 2563


Niclear magnetic resonance shift reagents: abnormal carbon-13 shifts produced by complexation of lanthanide chelates with saturated amines and n-butyl isocyanide, 562

Nuclear magnetic resonance shift reagents: evidence for different mechanisms of contact contributions to carbon-13 shifts induced by nickel and cobalt acetylacetonates with saturated amines and alcohols, 939

Nuclear magnetic resonance spectroscopy: 13C fourier transform spectra of A8- and A9-tetrahydrocannabinol, 1027

Nuclear polarization see Chemically-induced dynamic nuclear polarization

Nuclear receptor Thyroid hormone action in cell culture: demonstration of nuclear

receptors in intact cells and isolated nuclei, 3488 Nucleation

Nucleation, rapid folding, and globular intrachain regions in proteins, 697

Nucleic acid, iodine-125-labeled Fingerprinting techniques, application to iodinated nucleic acids,

3260 Iodine-125-labeled DNA.RNA hybrids in cytological preparations,

1536 Nucleic acid sequencing


Nucleic acid synthesis Macromolecular biosynthesis, regulation in mutant of

Escherichia coli defective in membrane phospholipid

biosynthesis, 385 Nucleolar protein

Nucleolar proteins of normal rat liver, comparison with Novikoff hepatoma ascites cells by two-dimensional polyacrylamide gel electrophoresis, 1316

Nucleon-nucleon scattering Magnetic moment effects on tests of charge independence in

nucleon-nucleon scattering (abstract), 2178 5':Nucleotidase (EC 3.1.3.5)

Plasma membranes from cultured muscle cells: isolation procedure and separation of putative plasma-membrane marker enzymes, 3195

Nucleotide containing mercury Synthesis and enzymatic polymerization of nucleotides containing

mercury: potential tools for nucleic acid sequencing, 2238 Nucleotide excision

Deoxyribonucleic acid repair that contains interstrand crosslinks in Escherichia coli: sequential excision and recombination, 1064

Nucleotide modification Nucleotide modification in vitro of precursor of transfer RNATYr

of Escherichia coli, 3626 Nucleotide modification in vitro of precursor of transfer RNATyr

of Escherichia coli (correction), 3932 Nucleotide sequence

Absence of G-T-~-C sequence from two mammalian initiator transfer RNAs, 1046

Absence of sequence G-T-4-C-G(A)- in several eukaryotic cytoplasmic initiator transfer RNAs, 1041


G-T-~-C-G(A)- sequence, replacement by G-A-U-C-G- in initiator transfer RNA of rabbit-liver cytoplasm, 2600

Multiple repressor binding at operators in bacteriophage X, 1531 Nucleotide sequence divergence in a-chain-structural genes of


Nucleotide sequence of HS-/ satellite DNA from kangaroo rat Dipodomys ordii, 2642

Nucleotide sequence of lac operator, 3581 Nucleotide sequence of lactose messenger ribonucleic acid

transcribed from UV5 promotor mutant of Escherichia coli, 3585


Ribonucleic acid-linked DNA fragments in vitro, 88 Ribonucleic acid-linked DNA fragments in vitro (correction), 1284 Sequence homology at the 5'-termini of insect messenger RNAs,

1355 3'-Terminal nucleotide sequences of bacteriophage A DNA, 1151

Nucleus see Cell nucleus

Nutrition Acceleration of rate of deamidation of GlyArgAsnArgGly and of

human transferrin by addition of l-ascorbic acid, 2122 "Recommended daily allowances" for vitamin C, 969 "Trophic" value of foods, 710

Octane degradative pathway Genetic fusion of incompatible plasmids in Pseudomonas, 1641

Octane plasmid Genetic regulation of octane dissimilation plasmid in

Pseudomonas, 1137 Oligonucleotide, synthetic


Oligopeptide permease Illicit transport: oligopeptide permease, 456

Oligosaccharide Metabolism of membrane phospholipids and its relation to novel

class of oligosaccharides in Escherichia coli, 1368 Oligothymidine

Biologically and chemically pure messenger ribonucleic acid, prepared with aid of antibodies and immobilized oligothymidine, that codes for mouse immunoglobulin L-chain, 2256

Oncogene Nuclear DNA sequences present in human leukemic cells and

absent in normal leukocytes (correction), 627 Oocyte, amphibian

Microinjection of rabbit hemoglobin messenger RNA into amphibian oocytes and embryos, 543

Oogenesis Polyadenylation of maternal RNA of sea urchin eggs after

fertilization, 2345 Operator

Multiple repressor binding at operators in bacteriophage A, 1531 Operator (Mathematics)

see also Pseudodifferential operator Operon, conjugated

Genetic model for Rh blood-group system, 1303 Operon, gal

Repression of transcription of gal operon by purified gal repressor in vitro, 334

Operon, his Histidine operon, inhibition of transcription in vitro by first

34 Subject Index




enzyme of histidine pathway, 2692 Operon, histidine utilization


Operon, lac Evolution of second gene for 3-galactosidase in Escherichia coli,

1841 Mutant of Escherichia coli with new, highly efficient promoter for

lactose operon, 3693 Nucleotide sequence of lac operator, 3581 Nucleotide sequence of lactose messenger ribonucleic acid


Splicing of protein in vivo: one continuous polypeptide from two independently functioning operons, 2969

Operon, trp Nucleotide sequences from tryptophan messenger RNA of

Escherichia coli: sequence corresponding to amino-terminal region of first polypeptide specified by operon, 2335

Repression of transcription of tryptophan operon by trp repressor in vitro, 1990

Optic lamina Neuronal connections in isogenic organisms: cellular interactions

in development of optic lamina of Daphnia, 433 Optic system

Adhesive recognition and retinotectal specificity, 2482 Neuronal connections in isogenic organisms: optic system of

Daphnia magna, 57 Osmometer

Magnetic suspension osmometer, 3785 Osmotic pressure


Otic labyrinth Labyrinthine sense organs of frog, 498

Ovary cell see Chinese hamster ovary cell

Ovary, follicles Moth follicular cells, purification of family of specific messenger

ribonucleic acids, 3764 Oviduct



Oxaloacetate Oxaloacetate as Hill oxidant in mesophyll cells of plants


Oxidation-reduction potential Oxidation-reduction potentials of bound iron-sulfur proteins of

photosystem I, 2941 Oxidation state

Proton magnetic resonance spectra, dependence on oxidation state of flavodoxin from'Clostridium MP and from Peptostreptococcus elsdenii, 3292

Oxidative phosphorylation Electron transport-linked compared with proton-induced ATP

generation in Thiobacillus novellus, 3571 Oxidative phosphorylation, concept for energy coupling based on

molecular explanation of oxygen exchange reactions, 2837 5-Oxoprolinase

5-Oxoprolinase inhibition by 2-imidazolidone-4-carboxylic acid, 759

5-Oxoprolinuria 5-Oxoprolinase inhibition by 2-imidazolidone-4-carboxylic acid,

759 Oxygen affinity

Aspirin, effect on sickling and oxygen affinity of erythrocytes, 3707

Oxygenation Stereochemical trigger for initiating cooperative interaction of

subunits during oxygenation of cobaltohemoglobin, 3919 Oxygen binding

Contribution of a and 3 chains to kinetics of oxygen binding to and dissociation from hemoglobin, 1


Myoglobin, synthesis of active site, 2647 Nicotinic acid as ligand affecting leghemoglobin structure and

oxygen reactivity, 564 Resonance Raman studies of electronic state of oxygen in

hemerythrin, 2582 Oxygen equilibrium

Oxygen equilibrium and kinetics of isolated subunits from hemoglobin Kansas, 1718

Oxygen exchange reaction Oxidative phosphorylation, concept for energy coupling based on

molecular explanation of oxygen exchange reactions, 2837 Oxytocin

Conformational studies of oxytocin, lysine vasopressin, arginine vasopressin, and arginine vasotocin by carbon-13 nuclear magnetic resonance spectroscopy, 2086



Subject Index 35

Pactamycin Inhibition of reticulocyte peptide-chain initiation by pactamycin:

accumulation of inactive ribosomal initiation complexes, 22 Pagurus pollicaris


Palatability spectrum Automimicry, theoretical investigations: multiple trial learning

and palatability spectrum, 2261 Pancreas

Early differentiation of glucagon-producing cells in embryonic pancreas: possible developmental role for glucagon, 3478

Immunoferritin localization of intracellular antigens: use of ultracryotomy to obtain ultrathin sections suitable for direct immunoferritin staining, 1649

Papovavirus Malignant transformation of BHK21 clone 13 cells by BK virus: a

human papovavirus, 3210 Parabolic subgroup

Unipotent groups in invariant theory, 646 Parathyroid hormone

Microsomal precursor to human parathyroid hormone: preliminary evidence, 2291

Parenchyma 8-Bromoadenosine 3':5'-cyclic monophosphate as promoter of cell

division in excised tobacco pith parenchyma tissue, 447 Parthenogenetic strain

Genetic system in parthenogenetic strains of Drosophila mercatorum, 1772

Particle physics Colliding beams versus beams on stationary targets: competing

tools (N.A.S. Symposium: new accelerators), 611 Passive cutaneous anaphylaxis

Immunological tolerance, induction in bone marrow-derived lymphocytes of IgE antibody class, 2776

Peabody Picture Vocabulary Test How biased are culture-loaded tests? (abstract), 3935

Pepsin, porcine Amino acid sequence of porcine pepsin, 3437

Peptide Mode of action of vitamin K: isolation of peptide that contains

vitamin K-dependent portion of prothrombin, 3366 Peptide chain termination

Guanine nucleotides and elongation factors, influence on interaction of release factors with ribosome, 2350


Peptide conformation Proton magnetic resonance study of peptide conformation: effect

of trifluoroethanol on oxytocin and 8-lysine-vasopressin, 1199 Peptide synthesis

see also Protein synthesis Biological activities of synthetic peptides corresponding to

fragments of and to entire sequence of vasoactive intestinal peptide, 382


Nucleation, rapid folding, and globular intrachain regions in proteins, 697

Peptide fragments of apolipoprotein-alanine: chemical synthesis and biochemical properties, 2124

Peptide synthesis, initiation of Discriminatory ribosome rebinding of isolated regions of protein



Polypeptide initiation, stimulation in vitro after protein synthesis inhibition in vivo in HeLa cells, 2678

Peptidyltransferase Mapping of Escherichia coli ribosomal components involved in

peptidyl transferase activity, 1423 Protein involved in peptidyltransferase activity of Escherichia

coli ribosomes, 1931 Peptostreptococcus elsdenii


Perhydrohistrionicotoxin Acetylcholine receptor and ion conductance modulator sites at


Periplasmic protein f-Methylgalactoside transport system and galactose-binding

protein, regulation by cell cycle of Escherichia coli, 1481 Permeability

see Membrane permeability pH

Environmental pH effect on rescue of simian virus 40, 366 Glutaminase activity of glutamine amidotransferase

(carbamylphosphate synthetase), pH dependence, 2717 Phaseolus


Ribonucleic acid synthesis, stimulating substances isolated from red kidney bean: their activities in lymphocytes and Escherichia coli, 569




Phase separation Membrane lipids, lateral phase separations and tnechanism of

sugar transport in Escherichia coli, 2271 Relation between X lines and phase separations, 1241

Phase transition Lipid bilayer phase transition: density measurements and theory,

3443 Phenylalanine 4-hydroxylase (EC 1.14.3.1)

Hepatic phenylalanine 4-hydroxylase in classical phenylketonuria, 552

Phenylethanolamine Phenylethanolamine in brain and other tissues: demonstration

and distribution, 769 Phenylketonuria

Hepatic phenylalanine 4-hydroxylase in classical phenylketonuria, 552

Philadelphia chromosome see Chromosome, Philadelphia

Phlox Polymorphism for interspecific cross-compatibility in phlox, 1149

Phosphoglucomutase (EC 2.7.5.1) HL-A variants in cultured human lymphoid cells: isolation and

characterization, 1397 Loci for human PGM1 and 6PGD, regional localization on human


Phosphogluconate dehydrogenase (EC 1.1,1.43) Loci for human PGM1 and 6PGD, regional localization on human


Phospholipid Macromolecular biosynthesis, regulation in mutant of

Escherichia coli defective in membrane phospholipid biosynthesis, 385

Metabolism of membrane phospholipids and its relation to novel class of oligosaccharides in Escherichia coli, 1368

Peptide fragments of apolipoprotein-alanine: chemical synthesis and biochemical properties, 2124

Polypeptide region of bovine prothrombin specific for binding to phospholipids, 1344


Phospholipid vesicle Phospholipid vesicles, fusion of, with viable Acholeplasma

laidlawii, 1238 Phosphoprotein phosphatase


Phosphorescence Triplet-triplet energy transfer in a-trypsin, 3703 Tyrosyl residue, role in mechanism of action of carboxypeptidase

B: luminescence studies, 2025 Phosphoribosylpyrophosphate synthetase

see Ribosephosphate pyrophosphokinase Phosphorylation

see also Oxidative phosphorylation; Photophosphorylation 5-Bromodeoxycytidine, phosphorylation in cells infected with

herpes simplex virus, 3788 Phosphorylation of human platelet myosin, 3115 Phosphorylation of ribosomal proteins by substrate-specific

protein kinases from rabbit reticulocytes, 373 Phosphorylation of specific protein regulation in toad-bladder



Photoaffinity labeling Adenosine 3':5'-cyclic monophosphate receptor, specific


Photoaffinity labeling, mechanism of, 2567 Photochemistry

Heme proteins: effect of intermediate on photochemical behavior, 1550

Photodissociation Heme proteins: quantum yield determined by pulse method, 3141 Interpretation of binding of carbon monoxide to hemoglobin under

photodissociating conditions, 673 Photooxidation


Photophosphorylation Photophosphorylation by monomolecular films at air-water

interface, 50 Photoreaction

Poly(deoxyadenylic acid), specific photoreaction, 2683 Photoreceptor cell

Acetylcholine biosynthesis in turtle photoreceptors (correction), 284


Photoreceptor membrane New photoreceptor membrane, functions of, 2853

Photorespiration Plant productivity and control of photorespiration (N.A.S.

symposium: plant growth regulation), 579

Photoreversible conductance change Photoreversible conductance changes induced by phytochrome in

model lipid membranes, 762 Photosynthesis

Oxaloacetate as Hill oxidant in mesophyll cells of plants possessing C4-dicarboxylic acid cycle of leaf photosynthesis, 3730

Photophosphorylation by monomolecular films at air-water interface, 50

Photosystem I Chlorophyll composition and photochemical activity of


Oxidation-reduction potentials of bound iron-sulfur proteins of photosystem I, 2941


Photosystem II Free radical detection in primary reaction of chloroplast

photosystem II, 294 Phototaxis


Physical sciences see Applied physical science

Physics see also Particle physics Molecule microscope: new instrument for biological and

biomedical research, 2781 Thermal motion and forced migration of colloidal particles

generate hydrostatic pressure in solvent, 124 Physiology, developmental

Cats reared in stroboscopic illumination: effects on receptive fields in visual cortex, 1353

Phytochrome Photoreversible conductance changes induced by phytochrome in

model lipid membranes, 762 Phytochrome, binding properties to membrane fraction in vitro,

3861 Phytohemagglutinin

Human lymphotoxin: purification and some properties, 27 Ribonucleic acid synthesis, stimulating substances isolated from

red kidney bean: their activities in lymphocytes and Escherichia coli, 569

Pineal gland Catecholamine transmitter regulates supersensitivity and

subsensitivity of /-adrenergic receptor in pineal gland, 2411 Pineal indole biosynthesis, control of by changes in sympathetic

tone caused by factors other than environmehtal lighting, 1704 Pineal protein kinase: effect of enzymic phosphorylation on


2,5-Piperazinedione, N, N'-dimethyl-3,6-epitetrathio- Crystal structures of 2,5-piperazinediones having epipolysulfide

bridges between-C3 and C6: structures of N,N'-dimethyl-3,6-epitetrathio-2,5-piperazinedione, 279

Pituitary Hepatic /-hydroxy-{-methylglutaryl coenzyme A -eductase


Pituitary extract Pituitary extracts and steroid hormones in control of 3T3 cell

growth, 2702 Pituitary growth hormone

Primary structure of somatostatin: hypothalamic peptide that inhibits secretion of pituitary growth hormone, 684

Pituitary hormone Rat mammary,carcinoma in vivo and in vitro: establishment of

clonal lines of tumor, 1922 Placenta

Placental alkaline phosphatase, structural comparison of ectopic and normal, 2936

Plant Hybridization of leucyl-transfer ribonucleic acid isoacceptors



Oxaloacetate as Hill oxidant in mesophyll cells of plants possessing C4-dicarboxylic acid cycle of leaf photosynthesis, 3730

Sodium dynamics in northern ecosystem, 2745 Plant cell



Plant growth Competition among plants (N.A.S. Symposium: plant growth

regulation), 585 Ethylene in plant growth (N.A.S. Symposium: plant growth

regulation), 591 Plant productivity and control of photorespiration (N.A.S.

symposium: plant growth regulation), 579 Plant membrane

see Membrane, plant Plasma

see also Blood plasma; Membrane, plasma

36 Subject Index




Plasma aggregating factor Plasma aggregating factor (bovine) for human platelets: marker

for study of antihemophilic and von Willebrand factors, 2814 Plasma cell


Plasmacytoma Mouse lambda-chain sequences, 2112

Plasmid see also Octane plasmid; Colicin; specific plasmid Construction of biologically functional bacterial plasmids in vitro,

3240 Deoxyribonucleic acid, isolation of circular molecules from whole

cellular DNA by use of ATP-dependent deoxyribonuclease, 2884 Genetic fusion of incompatible plasmids in Pseudomonas, 1641 Recircularization and autonomous replication of sheared R-factor

DNA segment in Escherichia coli transformants, 1293 Ribonucleic acid, size and base composition in supercoiled

plasmid DNA, 3744 Plasmid, transmissible

Transmissible plasmid controlling camphor oxidation in Pseudomonas putida, 885

Platelet Phosphorylation of human platelet myosin, 3115 Plasma aggregating factor (bovine) for human platelets: marker

for study of antihemophilic and von Willebrand factors, 2814 Pleiotypic control


Plethodon cinereus Adaptive linkage disequilibrium between two esterase loci of

salamander, 1156 Pleurodeles waltlii


Polarographic catalytic wave Polarographic catalytic waves observed with bovine-serum


albumin: kinetic or diffusion control (correction), 2710 Pollen mixture

Polymorphism for interspecific cross-compatibility in phlox, 1149 Pollination

Ultraviolet patterns on rear of flowers: basis of disparity of buds and blossoms, 1002

Polyacrylamide gel electrophoresis, two-dimensional Nucleolar proteins of normal rat liver, comparison with Novikoff


Polyadenylate In vitro translation of oogenetic messenger RNA of sea urchin



Ribonucleic acid that contains polyadenylate, in vitro synthesis by virion-associated RNA polymerase of vesicular stomatitis virus, 3566

Polyadenylylation Polyadenylation of maternal RNA of sea urchin eggs after

fertilization, 2345 Poly(L-alanine)

Helix-coil transition for poly(L-alanine) as measured by nuclear magnetic resonance, 331

Polyarteritis Tropism of Mycoplasma gallisepticum for arterial walls, 1545

Polychlorinated biphenyl Polychlorinated biphenyls: new type of inducer of cytochrome

P-448 in the liver, 1321 Poly(deoxyadenylic acid)

Poly(deoxyadenylic acid), specific photoreaction, 2683 Polydeoxythymidylate


Poly(inosinic acid)-poly(cytidylic acid) Poly(inosinic acid)-poly(cytidylic acid) inhibition of DNA

synthesis in synchronized HeLa cells, 3904 Polymorphism

see also Enzyme polymorphism Adaptive linkage disequilibrium between two esterase loci of

salamander, 1156 Polymorphism for interspecific cross-compatibility in phlox, 1149

Polyoma virus Adrenal glucocorticoids, effects on polyoma virus replication,

1088 Carbohydrate catabolism and enhancement of uptake of galactose

in hamster cells transformed by polyoma virus, 839 Galactose uptake into hamster cells, two distinct types of

enhancement: tumor-virus transformation and hexose starvation, 2502

Ribonucleic acid-linked short DNA fragments during polyoma replication, 412

Polypeptide chain Discriminatory ribosome rebinding of isolated regions of protein


Mechanism of puromycin action: fate of ribosomes after release of nascent protein chains from polysomes, 3866

Polypeptide-chain initiation, specific inhibitor in Escherichia coli,

Subject Index 37

2874 Reverse turn as polypeptide conformation in globular proteins,

538 Splicing of protein in vivo: one continuous polypeptide from two

independently functioning operons, 2969 Polypeptide, viral

Avian oncornavirus proteins, identification of large polypeptide precursor, 1734

Polyribosome Attachment of chloroplast polysomes to thylakoid membranes in

Chlamydomonas reinhardtii, 1554 Glutamine synthetase induction in embryonic neural retina:

immunochemical identification of polysomes involved in enzyme synthesis, 1667


Mitochondria, autonomy of, in Saccharomyces cerevisiae in production of messenger RNA, 111


Reticulocyte membrane proteins, biosynthesis by membrane-free polyribosomes, 1526


Polysaccharides see also Lipopolysaccharide; Mucopolysaccharide Complex formation between mycobacterial polysaccharides and

fatty acyl-CoA derivatives, 1146 Polyuronide


Poly (vinyladenine) Inhibition of murine leukemia virus replication by

poly(vinyluracil) and poly(vinyladenine), 1204 Poly (vinyluracil)

Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly (vinyladenine), 1204

Population see also Dysgenic subpopulation; Hybrid population, human

Population growth Global models of growth and competition, 3590 Population growth, generalized Verhulst laws, 3048

Population, natural Genetic variability in natural populations, 3928

Population structure, genetic Gene diversity, analysis in subdivided populations, 3321 Self-fertilization and genetic population structure in colonizing

land snail, 1186 Porphyrin

Stereochemical trigger for initiating cooperative interaction of subunits during oxygenation of cobaltohemoglobin, 3919

Positional information Cell contact model for cellular position determination in

development, 2396 Positive feedback control

Allantoin degradative enzymes, induction in Saccharomyces cerevisicie by last intermediate of pathway, 2340

Potassium Active transport model of sodium and potassium ions as mediated

by tetrameric enzyme, 275 Light-induced phase shifts of circadian leaf movements of

Phaseolus: comparison with effects of potassium and of ethyl alcohol, 3387

Potassium channel noise Relaxation spectra of potassium channel noise from squid axon

membranes, 876 Poxvirus

Poxviruses, biogenesis of: inactivation of host DNA polymerase by component of invading inoculum particle, 1726

Precambrian Ecological theory for sudden origin of multicellular life in late

Precambrian, 1486 Precursor

Collagen synthesis: disulfide-linked collagen precursor in chick bone, 2993

l-/-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole): new broad-spectrum antiviral agent, 1174


Microsomal precursor to human parathyroid hormone: preliminary evidence, 2291

Nucleotide modification in vitro of precursor of transfer RNA'Yr of Escherichin coli, 3626

Nucleotide modification in vitro of precursor of transfer RNA"Yr of Escherichia coli (correction), 3932

Purification of 14S messenger RNA of immunoglobulin light chain that codes for possible light-chain precursor, 451

Ribonucleic acid synthesis, early stimulation by erythropoietin in cultures of erythroid precursor cells, 3189


Predation Ecological theory for sudden origin of multicellular life in late

Precambrian, 1486 Predator-prey

Automimicry, theoretical investigations: multiple trial learning and palatability spectrum, 2261

Predator-prey patterns, 2069




Setae of first antennae of copepod Cyclops scutifer (Sars): structure and importance, 2656

Presynapse Presynaptic inhibition at inhibitory nerve terminals: new synapse

in crayfish stretch receptor, 2462 Price, profit-including

Optimality of profit-including prices under ideal planning, 2109 Primary dysbetalipoproteinemia

Primary dysbetalipoproteinemia: predominance of specific apoprotein species in triglyceride-rich lipoproteins, 2015

Private sector From knowledge to action: science and its uses (Scientific


Probe, chromophoric Substrate binding to active creatine kinase with thiol-bound

mercurinitrophenol chromophoric probe, 2858 Probe, fluorescent

e-Adenylated glutamine synthetase: internal fluorescence probe for enzyme conformation, 3134


Procambarus Presynaptic inhibition at inhibitory nerve terminals: new synapse

in crayfish stretch receptor, 2462 Proceedings of the National Academy of Sciences, USA

Author index to volume 70 of Proc. Nat. Acad. Sci. USA, 3937 Procollagen

see also Collagen Amino-terminal extension in high-molecular-weight collagens

from mature bovine skin, 1464 Cell-free synthesis of procollagen: L-929 fibroblasts as cellular

model for dermatosparaxis, 1378 Collagen and procollagen production by clonal line of Schwann

cells, 1943 Disulfide-linked procollagen, identification as biosynthetic

precursor of chick-bone collagen, 3521 Secretion and extracellular processing of procollagen by cultured

human fibroblasts, 361 Proflavine

'Cell-surface interactions: differential inhibition by proflavine of embryonic cell aggregation and production of specific cell-aggregating factor, 3111

Progeroid cell, human Deficient DNA repair in human progeroid cells, 977

Progesterone Induction rates of specific translatable messenger RNAs for

ovalbumin and avidin by steroid hormones, 1870 Proglucagon


Proline Different mechanisms of energy coupling for active transport of

proline and glutamine in Escherichia coli, 1514 Prolyl hydroxylase

Prolyl hydroxylase activation in L-929 fibroblasts by ascorbic acid, 1090

Prophylaxis Prophylaxis and immunization in mice by use of virus-free


Propionate Juvenile hormones, biosynthesis in Manduca sexta: labeling

pattern from mevalonate, propionate, and acetate, 2921 Prostaglandin

Adenosine 3':5'-cyclic monophosphate, role in early transport changes induced by serum and insulin in quiescent fibroblasts, 3609


Carbon-13 nuclear magnetic resonance spectra of prostaglandins and some prostaglandin analogs, 1579


Mutant of 3T3 cells with cyclic AMP metabolism sensitive to temperature change, 2906




Protease Concanavalin A-binding sites, comparative evaluation of

distribution on surfaces of normal, virally-transformed, and protease-treated fibroblasts, 1625

Protein Statistical mechanics applied to cooperative ligand binding to

proteins, 3914 y-Protein

y-Protein specified by bacteriophage X, purification and properties: inhibitor of host RecBC recombination enzyme, 2215

Protein, active sites of Photoaffinity labeling, mechanism of, 2567

Protein aggregation Factor VIII recombination after dissociation by CaCl2, 2326

Protein association Concerted formation of gel of hemoglobin S, 1506

Protein binding Chromatin acidic proteins with high affinity for deoxyribonucleic

acid: some binding parameters, 2524 Protein conformation

Medium-range interactions, role in proteins, 830 Nearest-neighbor amino acids, influence on conformation of

middle amino acid in proteins: comparison of predicted and experimental determination of /-sheets in concanavalin A, 1473

Protein Hal Protein Hal: partial deletion of "7" immunoglobulin gene(s) and

apparent reinitiation at internal AUG codon, 1073 Protein kinase

Adenosine 3':5'-cyclic monophosphate-dependent protein kinase, studies on orientation in human erythrocyte membranes, 3735

Cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and isolation of resistant variants, 76

Phosphorylation of ribosomal proteins by substrate-specific protein kinases from rabbit reticulocytes, 373

Pineal protein kinase: effect of enzymic phosphorylation on actinomycin D binding by, and template activity of, chromatin, 755

Protein kinase activity in erythrocyte ghosts of patients with myotonic muscular dystrophy, 1855

Protein-nucleic acid interaction Intervent dilution chromatography: concept for separation of

strongly interacting macromolecules, 2424 Protein pulsation

Transductional and structural principles of mitochondrial transducing unit, 904

Protein rIIA Association of rIIA protein with bacterial membrane, 1468

Protein S12 Ribosomal assembly influenced by growth in presence of

streptomycin, 2762 Protein, sulfenyl iodide

Stable solid model for protein sulfenyl iodides, 328 Protein synthesis factor


Protein synthesis in bacteria Anthranilate synthetase synthesis, regulation in vitro by N-gene

protein of phage lambda, 1078 Guanine nucleotides, role in protein synthesis: elongation factor G

and guanosine 5'-triphosphate,3'-diphosphate, 3250 Guanosine tetra- and pentaphosphate synthesis requires presence


Macromolecular biosynthesis, regulation in mutant of Escherichia coli defective in membrane phospholipid biosynthesis, 385



Protein synthesis in calf brain Elongation factor 1, multiple forms from calf brain, 3282

Protein synthesis in cell extract Double-stranded RNA as inhibitor of protein synthesis and as

substrate for nuclease in extracts of Krebs II ascites cells, 225 Inhibition of cellular protein synthesis by double-stranded RNA:

inactivation of initiation factor, 1222 Polypeptide initiation, stimulation in vitro after protein synthesis

inhibition in vivo in HeLa cells, 2678 Ribonucleic acid polymerase subunits of Escherichiu coli,

synthesis in vitro, 2420 Tobacco mosaic virus RNA and rabbit globin 9S RNA, efficient

translation in cell free system from commercial wheat germ, 2330

Translation of brome mosaic viral ribonucleic acid in cell-free system derived from wheat embryo, 1799

Protein synthesis in intact cell Induction of immunoglobulin M synthesis and secretion in bone

marrow-derived lymphocytes by locally concentrated concanavalin A, 416



Protein synthesis, "late" Phage-induced 5'-exonuclease, requirement for expression of late

genes of bacteriophage T5, 3502 Protein synthesis, mitochondrial


Mitochondrial protein synthesis: RNA with properties of eukaryotic messenger RNA, 350

Protein, transport of Differential transport of protein in axons: comparison between

sciatic nerve and dorsal columns of cats, 1521 Proteolysis


Cyclic adenosine monophosphate receptor: loss of cAMP-dependent DNA binding activity after proteolysis in presence of cyclic adenosine monophosphate, 2529

Fructose 1,6-biphosphatase: role of lysosomal enzymes in modification of catalytic and structural properties, 303

Proteus mirabilis Colicin K of Escherichia coli K235, 854




Prothrombin Mode of action of vitamin K: isolation of peptide that contains

vitamin K-dependent portion of prothrombin, 3366 Polypeptide region of bovine prothrombin specific for binding to

phospholipids, 1344 Proton-induced generation

Electron transport-linked compared with proton-induced ATP generation in Thiobacillus novellus, 3571

Proton transfer Molecular mechanism for action of molybdenum in enzymes:

coupled proton and electron transfer, 988 Protoplast

Protoplasts, use for genetic research (N.A.S. Symposium: plant growth regulation), 598

Provirus Linear association between cellular DNA and Epstein-Barr virus

DNA in human lymphoblastoid cell line, 2888 Pseudemys scripta elegans

Acetylcholine biosynthesis in turtle photoreceptors (correction), 284

Pseudodifferential operator Classes of spatially inhomogeneous pseudodifferential operators,

1500 Pseudomonas

Genetic regulation of octane dissimilation plasmid in Pseudomonas, 1137

Pseudomonas oleovorans Genetic fusion of incompatible plasmids in Pseudomonas, 1641

Pseudomonas putida Genetic fusion of incompatible plasmids in Pseudomonas, 1641 Transmissible plasmid controlling camphor oxidation in

Pseudomonas putida, 885 Pseudoplasmodia


Psychology Cycloheximide and acetoxycycloheximide: inhibition of tyrosine

hydroxylase activity and amnestic effects, 354 Psychomimetic anticholinergic drug

Acetylcholine-like molecular arrangement in psychomimetic anticholinergic drugs, 3103

Public sector From knowledge to action: science and its uses (Scientific


Pulmonary disease Cystic fibrosis: fractionation of fibroblast media that inhibits

ciliary activity, 548 Glycoproteins from patients with alveolar proteinosis, 973

Purine metabolism Feedback-resistant phosphoribosylpyrophosphate synthetase,

characterization from cultured, mutagenized hepatoma cells that overproduce purineS, 3698


Purine polyribonucleotide synthetase Purine polyribonucleotide synthetase from Escherichia coli, 2558

Purine precursor 1-/-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole): new

broad-spectrum antiviral agent, 1174 Purine synthesis

Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in family with gout and excessive purine synthesis, 2749


Puromycin Mechanism of puromycin action: fate of ribosomes after release

of nascent protein chains from polysomes, 3866 Thiostrepton, effect on recycling of Escherichia coli initiation

factor 2, 1939 Pyridoxal compound

Pyridoxal compounds as specific reagents for ( and f N-termini of hemoglobin, 2595

Pyrimidine Hydroxyphenylazopyrimidines: characterization of active forms



Pyrimidine dimer Pyrimidine dimers: method for detecting in DNA of bacteria

irradiated with low doses of ultraviolet light, 2753 Pyrophosphoryl group

Guanosine tetraphosphate (MS I), identification of, as insertion of pyrophosphoryl group into 3'-position in guanosine 5'-diphosphate, 306

Pyruvate Cytochalasin blocks sympathetic ganglionic transmission:

presynaptic effect antagonized by pyruvate, 1730

Quadratic field see Real quadratic field

Quasars Quasars as events in galaxy nuclei (abstract), 2179

Quinone Photooxidation of chlorophyll b by quinones studied by

chemically-induced dynamic nuclear polarization, 143

Subject Index 39

Racemization Racemization reaction of aspartic acid and its use in dating fossil

bones, 1331 Radiocarbon production

Heliomagnetic-geomagnetic modulation of radiocarbon production in earth's atmosphere (abstract), 2178

Radioimmunoassay Radioimmunoassay for human alpha1-fetoprotein, 526

Rain Downwind and upwind effects in Arizona cloud-seeding

experiment, 357 Raman spectroscopy

Disulfide bond dihedral angles from Raman spectroscopy, 2619 Resonance Raman studies of electronic state of oxygen in

hemerythrin, 2582

Rana catesbiana see also Frog Specificity of antibodies in amphibian larvae possessing small

number of lymphocytes, 1898 Rana pipiens

see also Frog Acquisition of specificity in cutaneous sensory neurons:

reconsideration of integumental specification hypothesis, 3684 Labyrinthine sense organs of frog, 498

Raven's Progressive Matrices How biased are culture-loaded tests? (abstract), 3935

RD 114-virus Natural host taxonomy of RNA tumor viruses, determination by




Reaction kinetics Singular perturbation method, application to reaction kinetics,

1588 Real quadratic field

"Metodo rapido" for finding real quadratic fields of class-number 1, 395

Rearrangement mode Stereochemical correspondence among chemically disparate

systems: spirocyclic phosphoranes, diarylmethanes, and cognates, 3445

Receptor, cholinergic Acetylcholine-like molecular arrangement in psychomimetic

anticholinergic drugs, 3103 Receptor for acetylcholine

Acetylcholine receptor and ion conductance modulator sites at murine neuromuscular junction: evidence from specific toxin reactions, 949

Acetylcholine receptor clusters on cultured muscle cells, 270 Acetylcholine receptors, regulation in relation to

acetylcholinesterase in neuroblastoma cells, 2902 Affinity-labeling of partially purified acetylcholine receptor from

electric tissue of Electrophorus, 3636 Purified eel acetylcholine receptor and anti-acetylcholine

receptor antibody, 3334

Receptor for adenosine 3':5'-cyclic monophosphate Adenosine 3':5'-cyclic monophosphate receptor, specific


Receptor for epidermal growth factor Epidermal growth factor: receptors in human fibroblasts and

modulation of action by cholera toxin, 2964 Receptor for glycine


Receptor for hormone Conformational analysis of thyrotropin releasing factor, 1456

Receptor for insulin Insulin-like activity of concanavalin A and wheat germ agglutinin:

direct interactions with insulin receptors, 485 Receptor for nerve growth factor

f3 Nerve growth factor receptor of avian dorsal root ganglia, properties of, 3884

Receptor for opiate Opiate-receptor binding, properties in rat brain, 2243

Receptor for thyroid hormone Thyroid hormone action in cell culture: demonstration of nuclear

receptors in intact cells and isolated nuclei, 3488 Receptor (membrane) -cytoplasmic interaction


Receptor-steroid complex Nuclear binding of steroid receptors: comparison in intact cells

and cell-free systems, 3415 Recommended daily allowance

Recommended daily allowances for vitamin C (ascorbic acid) (abstract), 1619

Refolding reaction Both fast and slow refolding reactions of ribonuclease A yield

native enzyme, 3347 Regeneration of limb

Synaptic differentiation in regenerating crab-limb muscle, 822




Relaxation method Fluctuation spectroscopy: determination of chemical reaction

kinetics from frequency spectrum of fluctuations, 870 Relaxation spectra

Relaxation spectra of potassium channel noise from squid axon membranes, 876

Release factor Guanine nucleotides and elongation factors, influence on

interaction of release factors with ribosome, 2350 Renilla

Synthesis of biologically active form of Renilla (sea pansy) luciferin, 120

Repressor Multiple repressor binding at operators in bacteriophage X, 1531 Self-regulated repressor protein of hut operons of Salmonella

typhimurium, isolation of, 808 Repressor, gal

Repression of transcription of gal operon by purified gal repressor in vitro, 334

Repressor, lac Amino-acid sequence of lac repressor, 3576 lac repressor fragment, reinitiation at codon other than AUG,

3165 Mutant of Escherichia coli with new, highly efficient promoter for

lactose operon, 3693 Repressor, trp

Repression of transcription of tryptophan operon by trp repressor in vitro, 1990

Rescue, viral Environmental pH effect on rescue of simian virus 40, 366

Reserpine Tyrosine hydroxylase protein, immunochemical demonstration of


Restriction enzyme see Enzyme, restriction

Reticulocyte Delayed removal of amino-terminal methionine from nascent

globin chains in sickle-cell anemia reticulocytes, 2059 Hemoglobin 3-chain synthesis, regulation in bone marrow

erythroid cells by a chains, 3405 Inhibition of reticulocyte peptide-chain initiation by pactamycin:

accumulation of inactive ribosomal initiation complexes, 22 Phosphorylation of ribosomal proteins by substrate-specific

protein kinases from rabbit reticulocytes, 373 Reticulocyte membrane proteins, biosynthesis by membrane-free

polyribosomes, 1526 Reticulocyte ribonucleic acid-dependent ribonucleic acid

polymerase, 3400 Ribosome dissociation factor from rabbit reticulocytes distinct

from initiation factor M3, 2220 Reticulocyte lysate system, rabbit


Retina Gap junctions between photoreceptor cells in the vertebrate

retina, 1677 Retinal ganglion cell

Positional information in retinal ganglion cells of Xenopus: assays for analysis of unspecified state, 507

Retinal pigment cell Differentiation of lens tissue from progeny of chick retinal

pigment cells cultured in vitro: demonstration of switch of cell types in clonal cell culture, 1495

Retinal rod Photoreceptors, regulation of cyclic nucleotide concentrations:


Retina, neural Cell-surface interactions: differential inhibition by proflavine of


Glutamine synthetase induction in embryonic neural retina: immunochemical identification of polysomes involved in enzyme synthesis, 1667

Plasma membranes, specific recognition by embryonic cells, 2794 Retinol

Retinol, in vitro binding to rat-tissue components, 3483 Retinotectal connection

Positional information in retinal ganglion cells of Xenopus: assays for analysis of unspecified state, 507

Retinotectal specificity Adhesive recognition and retinotectal specificity, 2482

Reverse transcriptase see Ribonucleic acid-dependent deoxyribonucleic acid polymerase

Reviews Neuropsychological studies in the USSR: a review (part I), 959 Neuropsychological studies in the USSR: a review (part II), 1278

Rhabdomyosarcoma cell Type-C virus in human rhabdomyosarcoma cells after

inoculation into NIH Swiss mice treated with antithymocyte serum, 859

Rheumatoid arthritis HL-A-linked human immune-response genes, 2157

Rhodopseudomonas spheroides Coupling between bacteriochlorophyll and membrane protein

synthesis in Rhodopseudomonas spheroids, 799

Rhodopsin New photoreceptor membrane, functions of, 2853 Photoreceptors, regulation of cyclic nucleotide concentrations:


Riboflavin-5'-phosphate Riboflavin-5'-phosphate, binding in flavoprotein: flavodoxin at

2.0-angstrom resolution, 3857 1-.-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-/-D-Ribofuranosyl-l,2,4-triazole-3-carboxamide (Virazole): new broad-spectrum antiviral agent, 1174

Ribonuclease see also Endoribonuclease Alkaline ribonuclease activity changes during compensatory

renal growth, 169 Immunoferritin localization of intracellular antigens: use of


Ribonuclease A Both fast and slow refolding reactions of ribonuclease A yield

native enzyme, 3347 Nuclear magnetic resonance study of thermal denaturation of

ribonuclease A: implications for multistate behavior at low pH, 914

Ribonuclease H see Hybrid nuclease

Ribonuclease III Synthesis of large precursor to ribosomal RNA in mutant of

Escherichia coli, 3361 T7 early ribonucleic acids and Escherichia coli ribosomal RNAs

are cut from large precursor RNAs in vivo by ribonuclease III, 3296

Ribonucleic acid see also Brome mosaic viral ribonucleic acid "Early" virus-specific RNA may contain information necessary

for chromosome replication and mitosis induced by simian virus 40, 1654

Ribonucleic acid components of murine sarcoma and leukemia viruses, 3536

Ribonucleic acid from noninfectious virions produced by sarcoma positive-leukemia negative transformed 3T3 cells, 3002

Ribonucleic acid-linked short DNA fragments during polyoma replication, 412

Ribonucleic acid related to that of murine leukemia virus in Burkitt's tumors and nasopharyngeal carcinomas, 5


Ribonucleic acid that multiplies indefinitely with DNA-dependent RNA polymerase: selection from random copolymer, 934

Ribonucleic acid, base composition Ribonucleic acid, size and base composition in supercoiled

plasmid DNA, 3744 Ribonucleic acid C-type virus

Host-gene control of type-C RNA tumor virus expression and tumorigenesis in inbred mice, 1450

Ribonucleic acid-deoxyribonucleic acid hybridization General method of gene isolation, 1697 Iodine-125-labeled DNA.RNA hybrids in cytological preparations,

1536 Light-chain gene reiteration of mouse immunoglobulin, estimation

of, by DNA-RNA hybridization, 173 Ribonucleic acid from noninfectious virions produced by sarcoma

positive-leukemia negative transformed 3T3 cells, 3002 Ribonucleic acid-dependent deoxyribonucleic acid polymerase, as a

tool Enzymatic synthesis of DNA complementary to purified 14S

messenger RNA of immunoglobulin light chain, 693 Globin messenger sequences in giant nuclear precursors of

messenger RNA of avian erythroblasts, 1122 Leukemia-specific DNA sequences in leukocytes of leukemic

member of identical twins, 2629 Mouse mammary tumor virus, production in vitro in mouse

mammary tumor ascites line, 2983 Synthesis of [3H]DNA complementary to ovalbumin messenger

RNA: evidence for limited copies of ovalbumin gene in chick oviduct, 3776



Ribonucleic acid-dependent deoxyribonucleic acid polymerase, bacterial

Reverse transcription by Escherichia coli DNA polymerase I, 3834

Ribonucleic acid-dependent deoxyribonucleic acid polymerase, cellular


Ribonucleic acid-dependent deoxyribonucleic acid polymerase, human acute leukemia cells

Ribonucleic acid tumor virus-like DNA of primate is synthesized endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood cells, 3219

Ribonucleic acid-dependent deoxyribonucleic acid polymerase, human milk

Oncornaviruses in human milk: production of cores, 1976

40 Subject Index




Ribonucleic acid-dependent deoxyribonucleic acid polymerase in human brain tumor


Ribonucleic acid-dependent deoxyribonucleic acid polymerase, viral

Avian myeloblastosis virus, single subunit with both RNA-directed DNA polymerase and ribonuclease H activity, 230


Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA, 737

Evidence for 30-40S RNA as precursor of 60-70S RNA of Rous sarcoma virus, 401

Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine), 1204



Ribonucleic acid-dependent deoxyribonucleic acid polymerase of Rous sarcoma Virus, inhibition by thiosemicarbazones and several cations, 164

Ribonucleic acid-dependent deoxyribonucleic acid polymerase in type C viruses, specificity of DNA product II: quantitative analysis, 3923

Ribonucleic acid-directed deoxyribonucleic acid polymerase and virus-induced leukemia in mice, 1298

Type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum, 859

Ribonucleic acid-dependent ribonucleic acid polymerase, reticulocyte

Reticulocyte ribonucleic acid-dependent ribonucleic acid polymerase, 3400

Ribonucleic acid, double-stranded Double-stranded RNA as inhibitor of protein synthesis and as

substrate for nuclease in extracts of Krebs II ascites cells, 225 Inhibition of cellular protein synthesis by double-stranded RNA:

inactivation of initiation factor, 1222 Nucleic acid associated with killer strain of yeast, 1069

Ribonucleic acid, early and late Transcription of simian virus 40: mapping of "early" and "late"

species of RNA, 3711 Ribonucleic acid, high molecular weight


Ribonucleic acid, influenza virus Messenger activity of influenza virion RNA, 2960

Ribonucleic acid, initiation of Ribonucleic acid, initiation of, with dinucleoside monophosphates


Ribonucleic acid, iodinated Iodinated RNA, use for gene localization, 1860

Ribonucleic acid, maternal Cell-free translation of maternal messenger RNA from sea urchin

eggs, 2614 Cytoplasmic adenylylation and processing of maternal RNA, 406 Maternal histone messenger RNA: detection by molecular

hybridization, 2840 Polyadenylation of maternal RNA of sea urchin eggs after

fertilization, 2345 Ribonucleic acid, messenger

Discriminatory ribosome rebinding of isolated regions of protein synthesis initiation from ribonucleic acid of bacteriophage R17, 2605

Double-stranded RNA as inhibitor of protein synthesis and as substrate for nuclease in extracts of Krebs II ascites cells, 225

Functional and structural integrity of messenger RNA, 2171 Interferon treatment, effect on cellular messenger RNA, 3815 Messenger RNA for hepatic tryptophan oxygenase: partial

purification, translation in heterologous cell-free system, and control by glucocorticoid hormones, 1218

Messenger RNAs of Newcastle disease virus by gel electrophoresis, separation, 2544

Messenger selection by bacterial ribosomes, 2364 Mitochondrial protein synthesis: RNA with properties of

eukaryotic messenger RNA, 350 Moth follicular cells, purification of family of specific messenger

ribonucleic acids, 3764 Nucleotide sequence of lactose messenger ribonucleic acid






Sequence homology at the 5'-termini of insect messenger RNAs, 1355

T7 early RNAs are generated by site-specific cleavages, 1559

Subject Index 41


Ribonucleic acid, messenger activity Messenger activity of influenza virion RNA, 2960

Ribonucleic acid, messenger, cytoplasmic Cytoplasmic messenger RNA stability in HeLa cells, 115

Ribonucleic acid, messenger, early T7 early ribonucleic acids and Escherichia coli ribosomal RNAs

are cut from large precursor RNAs in vivo by ribonuclease III, 3296

Ribonucleic acid, messenger, gastrula Nonrepetitive deoxyribonucleic acid sequence representation in

sea urchin embryo messenger RNA, 3516 Ribonucleic acid, messenger, globin

5-Bromo-2'-deoxyuridine, effects on production of globin messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells, 2956



Globin gene, tissue-specific transcription in isolated chromatin, 3440


Globin ribonucleic acid, synthesis from duck-reticulocyte chromatin in vitro, 2029


Reticulocyte ribonucleic acid-dependent ribonucleic acid polymerase, 3400

Thalassemia, decreased globin messenger RNA detected by molecular hybridization, 1886


Tobacco mosaic virus RNA and rabbit globin 9S RNA, efficient translation in cell free system from commercial wheat germ, 2330


Riibonucleic acid, messenger, immunoglobulin Biologically and chemically pure messenger ribonucleic acid,

prepared with aid of antibodies and immobilized oligothymidine, that codes for mouse immunoglobulin L-chain, 2256



Purification of 14S messenger RNA of immunoglobulin light chain that codes for possible light-chain precursor, 451

Ribonucleic acid, messenger, interferon Interferon messenger RNA activity, stabilization by treatment of

cells with metabolic inhibitors and lowering of incubation temperature, 3909

Ribonucleic acid, messenger, oogenetic In vitro translation of oogenetic messenger RNA of sea urchin

eggs and piconavirus RNA with cell-free system from sarcoma 180, 3287

Ribonucleic acid, messenger, ovalbumin and avidin Induction rates of specific translatable messenger RNAs for

ovalbumin and avidin by steroid hormones, 1870 Synthesis of [3H]DNA complementary to ovalbumin messenger

RNA: evidence for limited copies of ovalbumin gene in chick oviduct, 3776

Ribonucleic acid, nucleolar Secondary structure maps of RNA: processing of HeLa ribosomal

RNA, 2827 Ribonucleic acid nucleotidyltransferase

Deoxyribonucleic acid in chromatin, accessibility to DNA polymerase and RNA polymerase, 1326

Histones, addition to histone-depleted nuclei: effect on template activity toward DNA and RNA polymerases, 2637

In vitro transcription of viral-specific sequences present in chromatin of cells transformed by simian virus 40, 3506



Ribonucleic acid polymerase from Bacillus amyloliquefaciens infected with 029 bacteriophage, 2234

Ribonucleic acid polymerase, modification after T3 phage infection of Escherichia coli B, 2845


Ribonucleic acid polymerase of Escherichia coli, regulation of subunit synthesis, 2651

Ribonucleic acid polymerase subunits of Escherichia coli, synthesis in vitro, 2420


Rifamycin derivatives, action on RNA polymerase of human leukemic lymphocytes, 2072

Selective extraction of histones, effects on template activities of






Transcription of rat-liver chromatin with homologous enzyme, 1161

Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6) Ribonucleic acid polymerase binding sites of Escherichia coli,


Ribonucleic acid nucleotidyltransferase, deoxyribonucleic acid- dependent

Eukaryotic DNA-dependent RNA polymerase stimulation by protein factors, 1383

Ribonucleic acid polymerases of maize: purification and molecular structure of DNA-dependent RNA polymerase II, 2386

Ribonucleic acid that multiplies indefinitely with DNA-dependent RNA polymerase: selection from random copolymer, 934


Ribonucleic acid of mengo virus In vitro translation of oogenetic messenger RNA of sea urchin


Ribonucleic acid polymerase see Ribonucleic acid nucleotidyltransferase

Ribonucleic acid processing Cytoplasmic adenylylation and processing of maternal RNA, 406

Ribonucleic acid-protein complex Adenosine triphosphatase and guanosine triphosphatase activities

associated with specific 5S RNA-protein complex, 2870 Ribonucleic acid-protein interaction

Native ribonucleoprotein complex from Escherichia coli ribosomes, 665

Ribonucleic acid, replicative Membrane binding of replicative RNA of bacteriophage MS2, two

classes, 2381 Ribonucleic acid, ribosomal


Independent control of ribosomal gene replication in polytene chromosomes of Drosophila melanogaster, 1359


Secondary structure maps of RNA: processing of HeLa ribosomal RNA, 2827


T7 early ribonucleic acids and Escherichia coli ribosomal RNAs are cut from large precursor RNAs in vivo by ribonuclease III, 3296

Temperature-sensitive mutation affecting 28S ribosomal RNA production in mammalian cells, 1273

Ribonucleic acid-ribosome complex Elongation factor G, interaction with N-acetylphenylalanyl

transfer RNA-ribosome complexes, 3561 Ribonucleic acid, 4S

Amino-acid acceptor activity of "70S-associated" 4S RNA from avian myeloblastosis virus, 1184

Minor base composition of "70S-associated" 4S RNA from avian myeloblastosis virus, 865

Ribonucleic acid, site-specific cleavage T7 early RNAs are generated by site-specific cleavages, 1559

Ribonucleic acid synthesis Globin ribonucleic acid, synthesis from duck-reticulocyte

chromatin in vitro, 2029 Mitochondria, autonomy of, in Saccharomyces cerevisiae in

production of messenger RNA, 111 Ribonucleic acid-linked DNA fragments in vitro, 88 Ribonucleic acid-linked DNA fragments in vitro (correction), 1284 Ribonucleic acid polymerase mutation causing

temperature-sensitive sporulation in Bacillus subtilis, 1179 Ribonucleic acid synthesis, early stimulation by erythropoietin in

cultures of erythroid precursor cells, 3189 Ribonucleic acid synthesis, regulation in fibroblasts during

transition from resting to growing state, 2819 Ribonucleic acid synthesis, stimulating substances isolated from

red kidney bean: their activities in lymphocytes and Escherichia coli, 569


Transfer RNA synthesis in vitro, 179 Ribonucleic acid synthesis, defective


Ribonucleic acid, tobacco mosaic virus Rod-shaped virus assembly in vitro: reconstitution with cucumber


Ribonucleic acid, transfer Adjacent transfer RNA genes in Escherichia coli, 438 Amino-acid acceptor activity of "70S-associated" 4S RNA from

avian myeloblastosis virus, 1184 Guanosine tetra- and pentaphosphate synthesis requires presence




Synthesis and aminoacylation of 3'-amino-3'-deoxy transfer RNA and its activity in ribosomal protein synthesis, 2671


Transfer RNA synthesis in vitro, 179 Ribonucleic acid, transfer, N-acetylphenylalanyl

Elongation factor G, interaction with N-acetylphenylalanyl transfer RNA-ribosome complexes, 3561

Ribonucleic acid, transfer, chloroplast Cytoplasmic regulatory mutant of Euglena: constitutivity for

light-inducible chloroplast transfer RNAs, 1749 Ribonucleic acid, transfer, initiator

Absence of G-T-&-C sequence from two mammalian initiator transfer RNAs, 1046

Absence of sequence G-T-i-C-G(A)- in several eukaryotic cytoplasmic initiator transfer RNAs, 1041

Absence of sequence G-T-4-C-G-(A)- in several eukaryotic cytoplasmic initiator transfer RNAs (correction), 3274

G-T-~-C-G(A)- sequence, replacement by G-A-U-C-G- in initiator transfer RNA of rabbit-liver cytoplasm, 2600

Methionine transfer ribonucleic acids of avian myeloblastosis virus, 2823

Ribonucleic acid, transfer, leucine Hybridization of leucyl-transfer ribonucleic acid isoacceptors


Ribonucleic acid, transfer, methionine Methionine transfer ribonucleic acids of avian myeloblastosis

virus, 2823 Ribonucleic acid, transfer, methionyl (formylatable)


Thiostrepton, effect on recycling of Escherichia coli initiation factor 2, 1939

Ribonucleic acid, transfer, phenylalanine Conformation of charged and uncharged tRNAPhe, 2193 50S proteins, identification at peptidyl-tRNA binding site of

Escherichia coli ribosomes, 2799 Y base, effect of removal on conformation of yeast tRNAPhe,

3843 Ribonucleic acid, transfer, serine


Ribonucleic acid, transfer, structure of Determination of secondary and tertiary structural features of


Ribonucleic acid, transfer, tyrosine Nucleotide modification in vitro of precursor of transfer RNAyr

of Escherichia coli, 3626 Nucleotide modification in vitro of precursor of transfer RNAryr

of Escherichia coli (correction), 3932 Ribonucleic acid transport

Transport of 75S RNA from discrete chromosome region via nuclear sap to cytoplasm in Chironomus tentans, 442

Ribonucleic acid tumor virus see also specific ribonucleic acid tumor viruses Adrenal corticosteroids enhance production of type-C virus

induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts, 2391

Deoxyribonucleic acid specific for Rous sarcoma virus, integration after infection of permissive and nonpermissive hosts, 3067




Natural host taxonomy of RNA tumor viruses, determination by molecular hybridization: application to RD-114, a candidate human virus, 1437



Oncornaviruses in human milk: production of cores, 1976 Particles with RNA of high molecular weight and RNA-directed

DNA polymerase in human brain tumors, 2789 Ribonucleic acid-dependent deoxyribonucleic acid polymerase of

Rous sarcoma virus, inhibition by thiosemicarbazones and several cations, 164

Structure of some murine RNA tumor viruses studied by lactoperoxidase iodination, 36

Ribonucleic acid, virus-related Burkitt's tumors contain particles encapsulating RNA-instructed



Ribonucleoprotein complex Native ribonucleoprotein complex from Escherichia coli

ribosomes, 665




Ribonucleotide Ribonucleotides in mature closed-circular mitochondrial DNA,

3339 Ribosephosphate pyrophosphokinase

Feedback-resistant phosphoribosylpyrophosphate synthetase, characterization from cultured, mutagenized hepatoma cells that overproduce purines, 3698

Ribosephosphate pyrophosphokinase (EC 2.7.6.1) Human phosphoribosylpyrophosphate synthetase: increased



Ribosomal assembly Ribosomal assembly influenced by growth in presence of

streptomycin, 2762 Ribosomal factor


Ribosome dissociation factor from rabbit reticulocytes distinct from initiation factor M3, 2220

Ribosomal protein Functional correspondence between 30S ribosomal proteins of

Escherichia coli and Bacillus stearothermophilus, 944 Phosphorylation of ribosomal proteins by substrate-specific

protein kinases from rabbit reticulocytes, 373 Proteins S5 and S9 from 30S subunits, requirement for

ribosome-dependent GTPase activity of elongation factor G, 151 Ribosomal protein S4 alteration by mutation linked to

kasugamycin-resistance in Escherichia coli, 71 Ribosomal proteins involved in interaction with elongation factor

G, 147 Synthesis and aminoacylation of 3'-amino-3'-deoxy transfer RNA

and its activity in ribosomal protein synthesis, 2671 Ribosomal subunit

Chloramphenicol-binding protein, identification in Escherichia coli ribosomes by partial reconstitution, 2224

Chloramphenicol-binding protein, identification in Escherichia coli ribosomes by affinity labeling, 2229



Mapping of Escherichia coli ribosomal components involved in peptidyl transferase activity, 1423


Proteins S5 and S9 from 30S subunits, requirement for ribosome-dependent GTPase activity of elongation factor G, 151

Ribosome Colicin E3: unique endoribonuclease, 156 Conformational control of interaction of eukaryotic elongation

factors EF-1 and EF-2 with ribosomes, 3556 Discriminatory ribosome rebinding of isolated regions of protein



Messenger selection by bacterial ribosomes, 2364 Ribosomes crosslinked with dimethylsuberimidate: structural and

functional properties (correction), 1618 Ribosome, chloroplast

Altered chloroplast ribosomal proteins associated with erythromycin-resistant mutants in two genetic systems of Chlamydomonas reinhardi (correction), 2176

Can non-Mendelian mutation affect both chloroplast and mitochondrial ribosomes? 3463

Ribosome, Escherichia coli Native ribonucleoprotein complex from Escherichia coli

ribosomes, 665 Protein involved in peptidyltransferase activity of Escherichia

coli ribosomes, 1931 50S proteins, identification at peptidyl-tRNA binding site of

Escherichia coli ribosomes, 2799 Ribosylzeatin


Ribulosebisphosphate carboxylase (EC 4.1.1.39) 3-Bromo-2-butanone 1,4-bisphosphate as affinity label for

ribulosebisphosphate carboxylase, 3721 Riemannian manifold

F-Deformations and F-tractions, 1634 Rifamycin

Rifamycin derivatives, action on RNA polymerase of human leukemic lymphocytes, 2072

Rod-shaped virus Rod-shaped virus assembly in vitro: reconstitution with cucumber


Rous sarcoma virus Avian sarcoma virus, isolation of defective mutant, 3493 Avian tumor virus RNA: comparison of three sarcoma viruses

and their transformation-defective derivatives by oligonucleotide fingerprinting and DNA-RNA hybridization, 2266

Subject Index 43

Deoxyribonucleic acid specific for Rous sarcoma virus, integration after infection of permissive and nonpermissive hosts, 3067


Ribonucleic acid-dependent deoxyribonucleic acid polymerase of Rous sarcoma virus; inhibition by thiosemicarbazones and several cations, 164



Temperature-dependent formation of dimers and oligomers of mitochondrial DNA in cells transformed by thermosensitive mutant of Rous sarcoma virus, 3739


Rubbery material Rubbery materials, new elastic potential function, 3041

Rumina decollata Self-fertilization and genetic population structure in colonizing

land snail, 1186 Ruthenium Red

Ruthenium Red, inhibitory action on neuromuscular transmission, 3613

Saccharomyces cerevisiae Allantoin degradative enzymes, induction in Saccharomyces

cerevisiae by last intermediate of pathway, 2340 Chromosome replication during meiosis: identification of gene

functions required for premeiotic DNA synthesis, 3087 Mitochondria, autonomy of, in Saccharomyces cerevisiae in

production of messenger RNA, 111 Synchronous mating in yeast, 1373 Y base, effect of removal on conformation of yeast tRNAPhe

3843 Yeast chromosomal deoxyribonucleic acid size and structure,

3072 Saguinus oedipus

Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus, 2487

Salamander see Plethodon cinereus

Salivary gland Calcium ions, importance for regulation of guanosine 3':5'-cyclic

monophosphate levels, 3889 Salmonella typhimurium



Nucleotide sequence divergence in ca-chain-structural genes of tryptophan synthetase from Escherichia coli, Salmonella typhimurium, and Aerobacter aerogenes, 1112


Sarcoma 180 In vitro translation of oogenetic messenger RNA of sea urchin


Sarcoma virus see also Rous sarcoma virus; Murine sarcoma virus Avian tumor virus RNA: comparison of three sarcoma viruses


Schizophyllum Mutational analysis of regulatory gene for morphogenesis in

Schizophyllum, 1427 School achievement

Fertility, IQ, and school achievement (abstract), 3935 Schwann cell

Collagen and procollagen production by clonal line of Schwann cells, 1943

Science From knowledge to action: science and its uses (Scientific


Scurvy "Recommended daily allowances" for vitamin C, 969

Sea pansy see Renilla

Sea urchin see Lytechinus pictus; Arbacia punctulata; Strongylocentrotus

purpuratus; Egg, sea urchin; Embryo, sea urchin Seismological inverse problem

Seismological inverse problem: informative solution, 1410 Self-fertilization

Self-fertilization and genetic population structure in colonizing land snail, 1186

Semilinear gradient operator equation Minimax principles for solution of semilinear gradient operator

equations in Hilbert space, 1519 Senescence

see Aging




Sense organ, peripheral Locomotor patterns, development in absence of peripheral sense

organs and muscles, 954 Sensory ganglion

Nerve growth factor and cyclic AMP, mechanism of action on neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation, 2448

Sepharose Antiviral effect of interferon covalently bound to Sepharose, 2360

Serotonin Intrasomatic injection of radioactive precursors for studying


Pineal indole biosynthesis, control of by changes in sympathetic tone caused by factors other than environmental lighting, 1704

Serum Adenosine 3':5'-cyclic monophosphate, role in early transport



Setae Setae of first antennae of copepod Cyclops scutifer (Sars):

structure and importance, 2656 Shear stability

Magnetofluid-dynamic spectrum and low shear stability, 3277 i-Sheet

Nearest-neighbor amino acids, influence on conformation of middle amino acid in proteins: comparison of predicted and experimental determination of p-sheets in concanavalin A, 1473

Sickle-cell anemia Aspirin, effect on sickling and oxygen affinity of erythrocytes,

3707 Delayed removal of amino-terminal methionine from nascent

globin chains in sickle-cell anemia reticulocytes, 2059 Human sickle-cell erythrocytes, survival in heterologous species:

response to variations in oxygen tension, 2356 Sickle cell hemoglobin

see also Hemoglobin S, deoxy- Sickle cell hemoglobin, fibers of, 1104 Structure of sickled erythrocytes and of sickle-cell hemoglobin

fibers, 718 Sigma factor


Sigma subunit Sigma activity of RNA polymerase of Bacillus subtilis, loss

during sporulation, 1865 Silicon


Silk worm see Bombyx mori

Silver Cesium sulfate gradients that contain both Hg2+ and Ag+ effect


Simian virus 40 Adhesion of cultured fibroblasts to insoluble analogues of

cell-surface carbohydrates, 2309 Concanavalin A-binding sites, comparative evaluation of



Environmental pH effect on rescue of simian virus 40, 366 In vitro transcription of viral-specific sequences present in

chromatin of cells transformed by simian virus 40, 3506 Membrane changes and adenosine triphosphate content in normal

and malignant transformed cells, 1780 Replication and transcription relationship of simian virus 40

DNA, 1927 Simian virus 40 sequences, in vitro transcription in SV3T3

chromatin, 2304 Simian virus 40 tumors, prevention by hamster fetal tissue:




Transcription of simian virus 40: mapping of "early" and "late" species of RNA, 3711

Sindbis virus Inhibition of murine leukemia virus replication by

poly (vinyluracil) and poly(vinyladenine), 1204 Singular perturbation method

Singular perturbation method, application to reaction kinetics, 1588

Skin Acquisition of specificity in cutaneous sensory neurons:

reconsideration of integumental specification hypothesis, 3684 Defect in Hunter syndrome: deficiency of sulfoiduronate

sulfatase, 2134 Epidermal growth factor: receptors in human fibroblasts and

modulation of action by cholera toxin, 2964

Skin, fibril formation Amino-terminal extension in high-molecular-weight collagens

from mature bovine skin, 1464 Skin scarification

Attempt to immunize guinea pigs against leukemia by skin scarification with leukemic cell suspensions, 3432

Skipjack see Euthynnus lineatus

Slime mold see Dictyostelium discoideum; Dictyostelium purpureum

Snail, land see Rumina decollata

Social cooperation Frequency-dependent natural selection model for evolution of

social cooperation networks, 187 Sodium

Active transport model of sodium and potassium ions as mediated by tetrameric enzyme, 275

Sodium dynamics in northern ecosystem, 2745 Sodium-selective ionophoric material from electric organ and

kidney membranes, 1191 Sodium uptake associated with activation of action potential

ionophores of cultured neuroblastoma and muscle cells, 3759 Sodium cyclamate


Sodium nitrite Protective effect of ascorbic acid on hepatotoxicity caused by

sodium nitrite plus aminopyrine, 747 Sodium-[Phe4, Val6]antamanide complex

Conformation Li-'antamanide complex and Na-[Phe4, Val6]antamanide complex, in crystalline state, 1836

Solar energy conversion Hydrogen evolution by chloroplast-ferredoxin-hydrogenase

system, 2317 Solution, colligative properties


Solvent effect Proton magnetic resonance study of peptide conformation: effect

of trifluoroethanol on oxytocin and 8-lysine-vasopressin, 1199 Solvent proton magnetic relaxation dispersion


Somatostatin Primary structure of somatostatin: hypothalamic peptide that

inhibits secretion of pituitary growth hormone, 684 South American Indians

"Private" genetic variants and frequency of mutation among South American Indians, 3311

Soybean agglutinin Neuraminidase-treated lymphocytes, transformation by soybean

agglutinin, 2515 Spatial localization of intracellular elements


Spatiotemporal organization Spatiotemporal organization, patterns in allosteric enzyme model,

3255 Spectral properties


Spectroscopy, fluctuation Fluctuation spectroscopy: determination of chemical reaction

kinetics from frequency spectrum of fluctuations, 870 Spectroscopy, high pressure optical

High-pressure spectral studies of mixed valence compounds of antimony, 3065

Spectroscopy, infrared Sodium deoxyribonucleate, direct evidence for C-like form of,

3352 Spectroscopy, polarized absorption

Hemoglobin S, structure and optical determination of molecular orientation in sickled erythrocytes, 3604

Spectrum, magnetofluid-dynamic Magnetofluid-dynamic spectrum and low shear stability, 3277

Spermatozoa a- and ,-Tublin, isolation and partial characterization from outer


Topographical location of H-Y antigen on mouse spermatozoa by immunoelectronmicroscopy, 1502

Sphingomyelin Ion-diffusion potentials and electrical rectification across lipid


Spinal cord, dorsal column Differential transport of protein in axons: comparison between

sciatic nerve and dorsal columns of cats, 1521 Spin label, amphiphilic

Amphiphilic spin labels, orientation and motion in hexagonal lipid phases, 1406

Spin-label technique Electron spin resonance studies of spin-labeled mammalian cells

by detection of surface membrane signals, 66 Pressure effect on membrane action of nerve-blocking spin label,

3179




Spin-state correlation Spin-state correlations in near infrared spectroscopy of

cytochrome c', 1851 Sporulation




Squalene Squalene and sterol carrier protein: structural properties,

lipid-binding, and function in cholesterol biosynthesis, 265 Squalus acanthius

Amino acid sequence of dogfish M4 lactate dehydrogenase, 1790 Amino acid sequence of dogfish M4 lactate dehydrogenase

(correction), 2467 Ss-Slp gene

Histocompatibility-2-linked Ss-Slp region, role in control of mouse complement, 863

Statistical mechanics Muscular contraction, theory extended to groups of actin sites,

2732 Statistical mechanics applied to cooperative ligand binding to

proteins, 3914 Statistics

Robust confidence interval for location for symmetric, long-tailed distributions, 1995

Steady-state metabolism Dynamics of metabolism of normal and virus-transformed chick

cells in culture, 2951 Stellate configuration


Stem cell, defective Congenital neutropenia: in vitro growth of colonies mimicking the

disease, 669 Stereochemistry


Stereochemical correspondence among chemically disparate systems: spirocyclic phosphoranes, diarylmethanes, and cognates, 3445

Stereospecific binding Stereospecific binding of potent narcotic analgesic [3H]etorphine

to rat-brain homogenate, 1947 Steroid

Adrenal glucocorticoids, effects on polyoma virus replication, 1088




Pituitary extracts and steroid hormones in control of 3T3 cell growth, 2702

Steroid receptor Nuclear binding of steroid receptors: comparison in intact cells

and cell-free systems, 3415 Sterol


Stomatitis virus see Vesicular stomatitis virus

Stopped-flow apparatus Stopped-flow apparatus with light-scattering detection and its

application to biochemical reactions, 890 Streptococcus lactis 7962

Galactoside, proton-coupled accumulation in Streptococcus lactis 7962, 2866

Streptomyces Aminoglycoside antibiotic-inactivating enzymes in actinomycetes


Streptomycin Polysomal ribosomes of Escherichia coli, partial inhibition by

streptomycin, 1234 Ribosomal assembly influenced by growth in presence of

streptomycin, 2762 Stroboscopic illumination

Cats reared in stroboscopic illumination: effects on receptive fields in visual cortex, 1353

Strongylocentrotus purpuratus cx- and B-Tublin, isolation and partial characterization from outer


In vitro translation of oogenetic messenger RNA of sea urchin eggs and piconavirus RNA with cell-free system from sarcoma 180, 3287

Nonrepetitive deoxyribonucleic acid sequence representation in sea urchin embryo messenger RNA, 3516

Structure-function relationship Contraction of isolated smooth-muscle cells: structural changes,

641 Functional and structural integrity of messenger RNA, 2171

Subject Index 45

Structure-function relationships in lactate dehydrogenase, 1968 Structure, secondary

Determination of secondary and tertiary structural features of transfer RNA molecules in solution by nuclear magnetic resonance, 2042

Globular protein, prediction of amount of secondary structure from amino acid composition, 2809

Secondary structure maps of RNA: processing of HeLa ribosomal RNA, 2827

Structure, tertiary Determination of secondary and tertiary structural features of


Tertiary structure for the hypothalamic thyrotropin-releasing factor, 1166

Structure, three-dimensional D-Glyceraldehyde-3-phosphate dehydrogenase: three-dimensional

structure and evolutionary significance, 3052 Fab' fragment, three dimensional structure of human

immunoglobulin at 2.8 angstrom resolution, 3305 Strychnine binding


Subacute sclerosing panencephalitis Oligoclonal immunoglobulin G antibody response in central

nervous system to different measles virus antigens in subacute sclerosing panencephalitis, 1060

Substrate binding Substrate binding to active creatine kinase with thiol-bound

mercurinitrophenol chromophoric probe, 2858 Subtilisin

Diazoacetyl subtilisin, 1132 Neutral to alkaline conversion of liver fructose


Succinimide, N-iodo- N-Iodosuccinimide reaction with goitrogens: model for active

iodine of thyroid gland, 1401 Sugarcane

Biochemical basis of resistance of sugarcane to eyespot disease, 1693

Sulfenyl iodide, protein Stable solid model for protein sulfenyl iodides, 328

Sulfhydryl group Acetylcholine receptors, regulation in relation to


acetylcholinesterase in neuroblastoma cells (correction), 3932 Amines, interaction with ketone aldehydes and unsaturated

aldehydes, 1030 Sulfhydryl site


Sulfite oxidase (EC 1.8.3.1) Molecular basis of biological function of molybdenum:

relationship between sulfite oxidase and acute toxicity of bisulfite and SO2, 3655

Sulfoiduronate sulfatase Defect in Hunter syndrome: deficiency of sulfoiduronate

sulfatase, 2134 Sulfur dioxide


Supermolecule Transductional and structural principles of mitochondrial

transducing unit, 904 Superoxide dismutase


Surf Internal swash and surf, 2379

Surface chemistry Photophosphorylation by monomolecular films at air-water

interface, 50 Surface of samples

Molecule microscope: new instrument for biological and biomedical research, 2781

Swash, internal Internal swash and surf, 2379

Sympathetic nervous system Cytochalasin blocks sympathetic ganglionic transmission:

presynaptic effect antagonized by pyruvate, 1730 Nerve growth factor receptor, binding in sympathetic ganglia,

2519 Tyrosine hydroxylase protein, immunochemical demonstration of


Synapse Acetylcholine receptor clusters on cultured muscle cells, 270 Hebb's postulate of learning: physiological mechanism, 997 Neuronal networks, theory of epigenesis by selective stabilization

of synapses, 2974 Presynaptic inhibition at inhibitory nerve terminals: new synapse

in crayfish stretch receptor, 2462 Ruthenium Red, inhibitory action on neuromuscular

transmission, 3613 Synaptic rearrangement in dentate gyrus: histochemical evidence

of adjustments after lesions in immature and adult rats, 3473




T-antigen gene T-antigen gene of simian virus 40, assignment to human

chromosome C-7, 3617 Tau-particles, defective

Head morphogenesis of bacteriophage T4: isolation, partial characterization, and fate of gene 21-defective tau-particles, 1636

Temperature-induced variation Temperature-induced variations in surface topology of cultured

lymphocytes are revealed by scanning electron microscopy, 2492

Temperature-sensitive mutant Genetic method for determining order of events in biological

pathway, 2046 Leucyl-transfer RNA synthetase, temperature sensitive in

mammalian cell mutant, 3094 Mutant of 3T3 cells with cyclic AMP metabolism sensitive to

temperature change, 2906 Mutants of Escherichia coli thermosensitive for synthesis of

transfer RNA, 2091 Temperature-dependent formation of dimers and oligomers of


Temperature-sensitive lethality in Nicotiana tabacum L., 108 Temperature-sensitive mutation affecting 28S ribosomal RNA

production in mammalian cells, 1273 Temperature-sensitive variants of established myoblast line, 425

Template activity see Deoxyribonucleic acid template activity

Template, single-stranded New form of DNA polymerase III and copolymerase replicate

long, single-stranded primer-template, 1764 Temporal frequency change



Tenebrio Sequence homology at the 5'-termini of insect messenger RNAs,

1355 Teratocarcinoma


Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture (correction), 3932

Teratoma Alkaline phosphatase activity in mouse teratoma, 3899

Tetracycline Stable RNA synthesis in stringent Escherichia coli cells in

absence of charged transfer RNA, 689 Tetrahydrocannabinol

Nuclear magnetic resonance spectroscopy: 13C fourier transform spectra of A8- and A9-tetrahydrocannabinol, 1027

Thalassemia Thalassemia, decreased globin messenger RNA detected by

molecular hybridization, 1886 Thalassemia syndromes, quantitative deficiency of chain specific

messenger ribonucleic acids, 1809 Theory, order-disorder

Lipid bilayer phase transition: density measurements and theory, 3443

Therapy, model for Enzyme loading of erythrocytes, 2663

Thermal motion Thermal motion and forced migration of colloidal particles

generate hydrostatic pressure in solvent, 124 Thiobacillu.s novellus

Electron transport-linked compared with proton-induced ATP generation in Thiobacillus novellus, 3571

Thiol, reactive Substrate binding to active creatine kinase with thiol-bound

mercurinitrophenol chromophoric probe, 2858 Thiosemicarbazone

Ribonucleic acid-dependent deoxyribonucleic acid polymerase of Rous sarcoma virus, inhibition by thiosemicarbazones and several cations, 164

Thiostrepton Adenosine triphosphatase and guanosine triphosphatase activities

associated with specific 5S RNA-protein complex, 2870 Thiostrepton, effect on recycling of Escherichia coli initiation

factor 2, 1939 L-Threonine deaminase

see Threonine dehydratase Threonine dehydratase (EC 4.2.1.16)

Autoregulation: role for biosynthetic enzyme in control of gene expression, 2757

Thymidine kinase (EC 2.7.1.21) Herpes simplex virus as source of thymidine kinase for thymidine

kinase-deficient mouse cells: suppression and reactivation of viral enzyme, 1912


Thymocyte Thymocytes from NZB mice of different ages, alteration in DNA

synthetic response, 3769 Thymus, calf

Ribonuclease H of calf thymus: purification and properties, 1959

Thymus cell, human Cell-surface immunoglobulin of human thymus cells and its

biosynthesis in vitro, 3716 Thymus-derived cell



Cellular basis for genetically controlled immunologic unresponsiveness in mice: tolerance induction in T-cells, 250



Thymus-derived cells, synergism between subpopulations mediating proliferative and effector phases of mixed lymphocyte reaction, 2707

Thyroid gland N-Iodosuccinimide reaction with goitrogens: model for active

iodine of thyroid gland, 1401 Stable solid model for protein sulfenyl iodides, 328

Thyroid hormone see also L-Triiodothyronine Mitochondrial adenosine diphosphate uptake, stimulation by

thyroid hormones, 98 Thyroid hormone action in cell culture: demonstration of nuclear

receptors in intact cells and isolated nuclei, 3488 Thyrotropin-releasing factor

Conformational analysis of thyrotropin releasing factor, 1456 Tertiary structure for the hypothalamic thyrotropin-releasing

factor, 1166 Tissue factor

Membrane lipoprotein activation of proteolytic system: mechanism of action of tissue factor, 310

Tissue-specific transcription Globin gene, tissue-specific transcription in isolated chromatin,

3440 Tobacco

see Nicotiana tabacum Tobacco hornworm moth

see Manducca sexta Tobacco mosaic virus

Rod-shaped virus assembly in vitro: reconstitution with cucumber green mottle mosaic virus protein and tobacco mosaic virus RNA (correction), 1618

D-a-Tocopherol Ion-diffusion potentials and electrical rectification across lipid


tof gene Regulation of expression of N gene of bacteriophage lambda, 421

Tolerance, immunological Cellular basis for genetically controlled immunologic

unresponsiveness in mice: tolerance induction in T-cells, 250 T particle

Prophylaxis and immunization in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus, 2105

F-Traction F-Deformations and F-tractions, 1634

Transferrin, human Acceleration of rate of deamidation of GlyArgAsnArgGly and of

human transferrin by addition of 1-ascorbic acid, 2122 Transformation of animal cells

Transfer of genetic information by purified metaphase chromosomes, 1258

Transformation of animal cells by chemical 5-Bromo-2'-deoxyuridine potentiation of transformation of



Malignant transformation of BHK21 clone 13 cells in vitro by nitrosamines: conditional state, 46


Transformation of animal cells by insulin Insulin effect on growth pattern and adenylate cyclase activity of

BHK fibroblasts, 1388 Transformation of animal cells by virus

Malignant transformation of BHK21 clone 13 cells by BK virus: a human papovavirus, 3210

Sugar effects on murine sarcoma virus transformation, 1364 Transformation of bacteria

Adenosine 3':5'-cyclic monophosphate as regulator of bacterial transformation, 471

Genetic transformation in Escherichia coli K12, 84 Marker discrimination in transformation and mutation of

pneumococcus, 3541 Recircularization and autonomous replication of sheared R-factor

DNA segment in Escherichia coli transformants, 1293 Separation of specific segments of transforming DNA after

treatment with endodeoxyribonuclease, 503 Transformed animal cells (Rous sarcoma virus)

Deoxyribonucleic acid specific for Rous sarcoma virus, integration after infection of permissive and nonpermissive

46 Subject Index




hosts, 3067 Dynamics of metabolism of normal and virus-transformed chick

cells in culture, 2951 Sugar transport in normal and Rous sarcoma virus-transformed

chick-embryo fibroblasts, 653 Transformation of chick-embryo fibroblasts by wild-type and

temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity, 1055

Transformed animal cells (simian virus 40) Adhesion of cultured fibroblasts to insoluble analogues of

cell-surface carbohydrates, 2309 Concanavalin A-binding sites, comparative evaluation of



Membrane structure, changes associated with cell contact, 3631 Mucopolysaccharides, production by normal and transformed

cells, 54 Simian virus 40 sequences, in vitro transcription in SV3T3

chromatin, 2304 Surface changes in temperature-sensitive simian virus

40-transformed cells, 347 Transformed cell line factor that affects cell migration, 369

Transformed animal cells (spontaneous) Antigenic properties of endogenous type-C viruses from

spontaneously transformed clones of BALB/3T3, 1598 Transformed animal cells (virus)



Deoxyglucose transport, growth and density-dependent inhibition in Balb 3T3 cells and its absence in cells transformed by murine sarcoma virus, 2374

Galactose uptake into hamster cells, two distinct types of enhancement: tumor-virus transformation and hexose starvation, 2502

Mucopolysaccharides, production by normal and transformed cells, 54

Temperature-dependent expression of transformation by cold-sensitive mutant of murine sarcoma virus, 2206

Transgenosis Transgenosis of genes from bacteria to plant cells: biological and

molecular evidence, 723 Translation of genetic information





Translation of bacteriophage Q/, RNA by cytoplasmic extracts of mammalian cells, 315


Transport see Active transport; Axonal transport; Calcium transport;

Carbohydrate transport; Electron transport; Glucose transport; Ion transport; Ribonucleic acid transport;

3-Methylgalactoside transport; Protein, transport of; Water transport

Tr gene Carcinogenesis, general theory, 3324

Trifluoroethanol Proton magnetic resonance study of peptide conformation: effect

of trifluoroethanol on oxytocin and 8-lysine-vasopressin, 1199 L-Triiodothyronine

see also Thyroid hormone Hepatic /-hydroxy-/-methylglutaryl coenzyme A reductase


Triplet-triplet energy transfer Triplet-triplet energy transfer in a-trypsin, 3703

a-Trypsin Triplet-triplet energy transfer in a-trypsin, 3703

Trypsinization of cells Glycopeptides from surface membranes of neuroblastoma cells,

1682 Trypsinized normal cells, reactivity with antibody presumably

specific for malignant cells, 325 DL-Tryptophan

DL-Tryptophan, resolution by affinity chromatography on bovine-serum albumin-agarose columns, 2850

Tryptophan analogue Repression of transcription of tryptophan operon by trp repressor

in vitro, 1990 Tryptophan fluorescence

Neutral to alkaline conversion of liver fructose 1,6-bisphosphatase: changes in molecular properties of enzyme, 661

Tryptophan oxygenase (EC 1.13.1.12) Messenger RNA for hepatic tryptophan oxygenase: partial

Subject Index 47

purification, translation in heterologous cell-free system, and control by glucocorticoid hormones, 1218

Tryptophan synthetase Nucleotide sequence divergence in a-chain-structural genes of


Tuberculosarcoidosis HL-A-linked human immune-response genes, 2157

d-Tubocurarine Acetylcholine receptor and ion conductance modulator sites at


Tubulin a- and 3-Tublin, isolation and partial characterization from outer


Microtubule assembly in the absence of added nucleotides, 765 Microtubule assembly in the absence of added nucleotides

(correction), 1903 Tumor-associated antigen


Purification of Hodgkin's disease tumor-associated antigens, 396 Tumor antigen in tissue cultures derived from patients with

Hodgkin's disease, 1540 Tumor-associated antigen in human nephroblastomas, 2051

Tumor, dibenzpyrene-induced Stimulation of host defense system by coenzyme Qio, effect on


Tumorigenesis Host-gene control of type-C RNA tumor virus expression and

tumorigenesis in inbred mice, 1450 Simian virus 40 tumors, prevention by hamster fetal tissue:


Tumor problem Programming of cells for death under defined experimental

conditions: relevance to tumor problem, 3055 Tumor protein

Placental alkaline phosphatase, structural comparison of ectopic and normal, 2936

Tumor-specific antigen Trypsinized normal cells, reactivity with antibody presumably

specific for malignant cells, 325 Tumor virus

see also Deoxyribonucleic acid tumor virus; Ribonucleic acid tumor virus; specific viruses

Tumor virus, avian Avian tumor virus RNA: comparison of three sarcoma viruses


rumor virus, murine mammary Mouse mammary tumor virus, production in vitro in mouse

mammary tumor ascites line, 2983 Structure of some murine RNA tumor viruses studied by

lactoperoxidase iodination, 36 Viral DNA polymerase in mouse milk: characterization and

separation, 2117 Tungsten


Turbidity effect Circular dichroism of chromaffin granule proteins in situ:

analysis of turbidity effects and protein conformation, 3458 Turtle

see Pseudemys scripta elegans Type-C virus

see C-type virus Tyrosinase

see also o-Diphenol oxidase Magnetic dipole-dipole coupled Cu(II) pairs in nitric oxide-treated


Tyrosine aminotransferase (EC 2.6.1.5) Human regulatory gene for inducible tyrosine aminotransferase

in rat-human hybrids, 1268 Tyrosine hydroxylase


Tyrosine hydroxylase protein, immunochemical demonstration of increased accumulation in sympathetic ganglia and adrenal medulla elicited by reserpine, 2767

Tyrosyl residue Tyrosyl residue, role in mechanism of action of carboxypeptidase

B: luminescence studies, 2025

Ultraviolet irradiation Pyrimidine dimers, method for detecting in DNA of bacteria

irradiated with low doses of ultraviolet light, 2753 Ultraviolet patterns on rear of flowers: basis of disparity of buds

and blossoms, 1002 Ultraviolet-stimulated DNA synthesis in toluenized Escherichia

coli deficient in DNA polymerase I, 129



48 Subject Index

Union of Soviet Socialist Republics see also National Academy of Sciences of USSR Neuropsychological studies in the USSR: a review (part I), 959 Neuropsychological studies in the USSR: a review (part II), 1278

Unipotent group Unipotent groups in invariant theory, 646

Urea Neutral to alkaline conversion of liver fructose


Uridine diphosphate-glucose 4-epimerase (EC 5.1.3.2) Carbohydrate catabolism and enhancement of uptake of galactose

in hamster cells transformed by polyoma virus, 839 Uridine diphosphate glucose-glycogen glucosyltransferase (EC

2.4.1.11) Hepatic glycogen synthesis, regulation during fetal development:

roles of hydrocortisone, insulin, and insulin receptors, 3454 Hydrophobic chromatography: use for purification of glycogen

synthetase, 778 Urocanate


Uterine protein synthesis Translational control of specific uterine protein synthesis after

estrogen induction, 18

Vaccinia virus HeLa cell deoxyribonucleic acid, breakdown mediated by

vaccinia virus, 3200 Poxviruses, biogenesis of: inactivation of host DNA polymerase

by component of invading inoculum particle, 1726 Vasoactive intestinal peptide

Biological activities of synthetic peptides corresponding to fragments of and to entire sequence of vasoactive intestinal peptide, 382

Vasopressin Phosphorylation of specific protein regulation in toad-bladder



Vasopressin, arginine Conformational studies of oxytocin, lysine vasopressin, arginine


Vasopressin, lysine Conformational studies of oxytocin, lysine vasopressin, arginine



Vasotocin, arginine Conformational studies of oxytocin, lysine vasopressin, arginine


Verhulst law Population growth, generalized Verhulst laws, 3048

Vesicular stomatitis virus Friend leukemia virus, host restriction: role of viral outer coat,

2549 Inhibition of murine leukemia virus replication by

poly(vinyluracil) and poly(vinyladenine), 1204 Prophylaxis and immunization in mice by use of virus-free



Vinblastine Pleiotypic control by cyclic AMP: interaction with cyclic GMP

and possible role of microtubules, 1659 Virazol

see 1-/3-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide Virus

see also Bacteriophage; Transformation of animal cells; Transformed animal cells; specific viruses

Carcinogenesis, general theory, 3324 Virus assembly

Rod-shaped virus assembly in vitro: reconstitution with cucumber green mottle mosaic virus protein and tobacco mosaic virus RNA (correction), 1618

Virus-induced fusion Cell cycle changes and the ability of cells to undergo

virus-induced fusion (correction), 965 Virus-like particle

Virus-like particles in extranuclear mutant of Neurospora crassa, 1574

Virus outer coat Friend leukemia virus, host restriction: role of viral outer coat,

2549 Virus plaque assay


Vision see also Optic system Cats reared in stroboscopic illumination: effects on receptive


fields in visual cortex, 1353 Vitamin B12

5-Methyltetrahydrofolate :homocysteine methyltransferase activity, regulation by methionine, vitamin B12, and folate in cultured baby hamster kidney cells, 2585

Vitamin C Acceleration of rate of deamidation of GlyArgAsnArgGly and of

human transferrin by addition of 1-ascorbic acid, 2122 Prolyl hydroxylase activation in L-929 fibroblasts by ascorbic

acid, 1090 Protective effect of ascorbic acid on hepatotoxicity caused by

sodium nitrite plus aminopyrine, 747 "Recommended daily allowances" for vitamin C, 969 Recommended daily allowances for vitamin C (ascorbic acid)

(abstract), 1619 Vitamin D3

lc-Hydroxycholecalciferol, synthetic analog of hormonal form of vitamin D3: biological activity, 2248

Vitamin K Mode of action of vitamin K: isolation of peptide that contains

vitamin K-dependent portion of prothrombin, 3366 Vocal behavior

Continuous noise, effects on avian hearing and vocal development, 1393

Volterra-Lotka equation Predator-prey patterns, 2069

Volvox Genetic control of development in Volvox: isolation and

characterization of morphogenetic mutants, 1335 von Willebrand factor

Plasma aggregating factor (bovine) for human platelets: marker for study of antihemophilic and von Willebrand factors, 2814

Waldenstrom macroglobulin Human anti-IgM iso-antibodies: detection of IgM allotypic

markers, 827 Water movement

Internal swash and surf, 2379 Surface circulation of lakes and nearly land-locked seas, 93

Water transport Membrane intercalated particles in human erythrocyte ghosts:


Watson-Crick base pair see Deoxyribonucleic acid base pair

Wave-interval Robust confidence interval for location for symmetric, long-tailed

distributions, 1995 Wax

Wax in coral mucus feeds tropical reef fishes (abstract), 3935 Weaver mutant mouse

Weaver mutant mouse cerebellum: defective neuronal migration secondary to abnormality of Bergmann glia, 240

Weierstrass integral F-Deformations and F-tractions, 1634

Wet chemical method Wet chemical method for rendering scanning electron microscopy

samples conductive and observations on surface morphology of human erythrocytes and Ehrlich ascites cells, 3599

Wheat embryo Translation of brome mosaic viral ribonucleic acid in cell-free

system derived from wheat embryo, 1799 Wheat germ


Wheat germ agglutinin Insulin-like activity of concanavalin A and wheat germ agglutinin:

direct interactions with insulin receptors, 485 Wilms' tumor

see Nephroblastoma, human Wolf

Sodium dynamics in northern ecosystem, 2745

Xanthine oxidase Molecular mechanism for action of molybdenum in enzymes:

coupled proton and electron transfer, 988 Xanthine oxidase (EC 1.2.3.2)


Xanthoma tuberosum see Primary dysbetalipoproteinemia

Xenopus Positional information in retinal ganglion cells of Xenopus: assays

for analysis of unspecified state, 507 Xenopus laevis



X-ray analysis, fluorescent Scanning transmission electron microscope studies of deep-frozen

unfixed muscle correlated with spatial localization of intracellular elements by fluorescent x-ray analysis, 3423

X-ray crystallography D-Glyceraldehyde-3-phosphate dehydrogenase:' three-dimensional

structure and evolutionary significance, 3052




Fab' fragment, three dimensional structure of human immunoglobulin at 2.8 angstrom resolution, 3305

Riboflavin-5'-phosphate, binding in flavoprotein: flavodoxin at 2.0-angstrom resolution, 3857

X-ray diffraction Aspartate transcarbamoylase from Escherichia coli: electron

density at 5.5 angstrom resolution, 1117 Carboxypeptidase A's, enzymatic activities in solution and in

crystals, 3797 Crystalline fragment of double helix: structure of dinucleoside

phosphate guanylyl-3',5'-cytidine, 849 Crystal structures of 2,5-piperazinediones having epipolysulfide

bridges between C3 and C6: structures of N, N'-dimethyl-3,6-epitetrathio-2,5-piperazinedione, 279

Structure-function relationships in lactate dehydrogenase, 1968 Structure of sickled erythrocytes and of sickle-cell hemoglobin

fibers, 718 Synthetic analogs of active sites of iron-sulfur proteins: structure

and properties of bis[o-xylyldithiolato-l2-sulfidoferrate (III)], an analog of 2Fe-2S proteins, 2429

Type-B DNA x-ray fiber diagrams, variation with base composition, 2167

X-ray laser "Experimental evidence of x-ray laser": comments on paper,

1227 Xylosyltransferase


Subject Index 49

Y base Y base, effect of removal on conformation of yeast tRNA"he,

3843 Yeast

see also Saccharomyces cerevisiae Yeast, killer strain

Nucleic acid associated with killer strain of yeast, 1069

Zea mays Lysine-rich histones of maize (Zea mays), two independently

inherited electrophoretic variants, 3043 Ribonucleic acid polymerases of maize: purification and

molecular structure of DNA-dependent RNA polymerase II, 2386

Zeatin cis-Zeatin, isolation from Corynebacterium fascians cultures,

3825 Cytokinins, biosynthesis in cytokinin-autotrophic tobacco callus,

658 Zeta function

Asymptotic formula for coordinates of zeros of sections of zeta function, 'N(S), near s = 1, 985

Zygote Synchronous mating in yeast, 1373



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