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Supplementary Figure 1

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Lovastatin. 0 µM. 2.5 µM. 5 µM. 10 µM. 25 µM. 50 µM. 80. % apoptosis. 70. 60. 50. 40. 30. Docetaxel. 0nM. 20. 24h. 48h. 72h. 96h. 1nM. 2.5nM. 5nM. 10. 7.5nM. 10nM. %apoptosis. 70. 0. 60. 50. 40. 30. 20. 10. 0. 24h. 48h. 72h. A. B. Supplementary Figure 1. - PowerPoint PPT Presentation
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Supplementary Figure 1 0 10 20 30 40 50 60 70 24h 48h 72h %apoptosis 0nM 1nM 2.5nM 5nM 7.5nM 10nM Docetaxel 0 10 20 30 40 50 60 70 80 24h 48h 72h 96h % apoptosis 0 µM 2.5 µM 5 µM 10 µM 25 µM 50 µM Lovastatin A B
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Page 1: Supplementary Figure 1

Supplementary Figure 1

0

10

20

30

40

50

60

70

24h 48h 72h

%ap

op

tosi

s

0nM1nM2.5nM5nM7.5nM10nM

Docetaxel

0

10

20

30

40

50

60

70

80

24h 48h 72h 96h

% a

po

pto

sis

0 µM2.5 µM5 µM10 µM25 µM50 µM

LovastatinA

B

Page 2: Supplementary Figure 1

HepG2

0

2

4

6

8

10

12

14

control L 12.5µM D 5nM L 12.5µM+ D 5nM

Cas

pas

e 3/

7 ac

tivi

ty

(arb

itra

ry u

nit

s)

H322

0123456789

control L 12.5µM D 5nM L 12.5µM + D 5nM

Cas

pas

e 3/

7 ac

tivi

ty

(arb

itra

ry u

nit

s)

24 h48 h

HeLa

0123456789

control L 12.5µM D 5nM L 12.5µM+ D 5nM

Cas

pas

e 3/

7 ac

tivi

ty

(arb

itra

ry u

nit

s)

Supplementary Figure 2

Page 3: Supplementary Figure 1

0

10

20

30

40

50

60

70

80

% a

po

pto

sis

control L 12.5µM V 0.5nML 12.5µM+ V 0.5nM

V 1nML 12.5µM+ V 1nM

***

***

***

***

***

† †

# # #

# #

† †

Supplementary Figure 3

Page 4: Supplementary Figure 1

Supplementary Figure 4

******# # #

***

control verapamil vinblastine vinblastine +verapamil

0

5

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20

25

30

35

40

45

% a

popt

osis

HGT-1HGT-1-D5

Page 5: Supplementary Figure 1

Supplementary Figure 5

HGT-1 HGT-1-D5

Signal patterns

2O2G 3O3G 4O4G 3O1G

HGT-1 100

HGT-1-D5 42 47.5 8 2.5


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