Supplementary S1
A
B
C
PS
D-9
5 (
r.u
)P
SD
-95
(r.
u)
PS
D-9
5 (
r.u
)
PSD-95
tubulin
tubulin
PSD-95
tubulin
A oligomers
Nicotine
-Btx
---
+--
++-
+++
-+-
--+
- -
+
- +-
A oligomers
Nicotine---
+--
++-
+++
+-Wortmannin
BSD
+A oligomers
Nicotine---
-+-
++-
+-
++
DHE
-
--+
1.5
1.0
0.5
0
2.0
1.0
0
1.0
0.5
0
PSD-95
Supplementary S2
BA
NicotineWild typeNicotine
Wild type
ControlWild type
ControlWild type
Afibrils A+Nicotine (100 M; 24h)
b
B
Supplementary S3
A a
Supplementary S4
A
C
B
*
*