Surveys 201917 LP Lipoproteins 17 NBSNewborn screening 18 OHHemoglobin derivates 18 OSBone...

Reference Institute for Bioanalytics Akkredited to DIN EN ISO/IEC 17043

Surveys 2019

2019

Quality assurance in medical laboratory

www.rfb.bio

ImprintDok. Nr. PH1-01 Version 1 2019Reference Institute for Bioanalyticsagency: Stiftung für Pathobiochemie und Molekulare DiagnostikFriesdorfer Straße 15353175 BonnGERMANY

contact:Telefon: +49 228 926895-0Telefax: +49 228 926895-29E-Mail: [email protected]

registered:registered in StiftungsverzeichnisRegierungspräsidium KarlsruheRegistriernummer: AZ 14-0563.1

sales tax ID:Umsatzsteuer-Identifikationsnummer gemäß §27 a Umsatzsteuergesetz:DE268787733

Editorial 1

Editorial

Dear participant,Dear prospective participant,

Your demand for appropriate quality assurance is growing alongside the advancement of medical laboratory tests. We would like to meet this quickly with our offerings. As the organisation appoint-ed by the German Medical Association for interlaboratory comparisons, we will offer all surveys in 2019 as stipulated in the quality assurance guidelines for laboratory testing.

Furthermore, from 2019 we will have new parameters in the programme that are exempt from surveys. Thus, we will now offer you on a regular basis a survey for faeces diagnostics (FD) after we have successfully tested the procedure in a pilot survey. The survey “sweat analysis” (SW) addresses the topic of cystic fibrosis screening. Furthermore, we have extended the spectrum of antibiotics (AK, Set 3). The number of tumour markers is also increasing continuously. To estab-lish new markers for this in future, we have set up a second survey for tumour markers (TMX) and will start with 3 parameters: chromogranin A, CA 50 and HER2/new.

The advancement of laboratory medicine described also impacts the Rili-BÄK [guidelines of the German Medical Association] with a new version of these currently in progress. For this reason, the survey conducted at the start of 2018 regarding the internal error limits has been analysed in the meantime with the successful participation of approx. 320 laboratories and was provided to the BÄK committee for their work.

Our online participants will certainly have noticed the effects of the GDPR [General Data Protec-tion Regulation] which came into force. We now require specific and transparent consent on your part to our data processing. Therefore, we have added this point to our programme booklet.

Of course nothing has changed in relation to the surveys as we had already stored your data only for the intended use and your data will not be disclosed to third parties. We thank you for the trust you have placed in us.

We also look forward to working with you in 2019!

Best regards from the RfB team

Dr. Wolf-Jochen Geilenkeuser Dr. Anja Kessler

2 Topics

Topics

Advices and explanations concerning the processes for registration and ordering are described on page 58.

Titles of individual chapters

- Quantitative determinations

- Qualitative determinations

- Direct detection of pathogens

- Ejaculate investigation

- Molecular- and cytogenetic investigations

In 2019, we will offer the following new surveys / analytes.

B1

AK (Therapeutic drug monitoring), Set 3: Meropenem, Linezolid ........................................................page 7

FD (Faeces diagnostics): Hemoglobin iFOBT assay (quantitative, qualitative), Hemoglobin /

haptoglobin complex (quantitative, qualitative), Elastase-1 (quantitative, qualitative), ..................................

Calprotectin (quantitative, qualitative) ............................................................................................... page 11

SW (Sweat analysis): chloride, conductivity .......................................................................................page 21

TMX (Tumor markers group 2): CA50, chromogranin A, ................................................................................

human epidermal growth factor receptor 2 .........................................................................................page 23

New ordersWhen ordering new surveys with sets please notice the correct entering of the sets desired.

FeesPlease note that the prices given in this program are net prices.

If you have any questions concerning External Quality Control or our brochureplease call +49 228 926895-0or send us an e-mail [email protected]

List of contents 3

General informations 2 Topics 3 List of contents 5 Internet / homepage / e-mail 6 Registration as online user 51 RfB office 51 Survey directors 51 Reference laboratories 51 Scientific advisors 52 Conditions of participation 53 Data protection declaration 58 How to order surveys 58 Changes of orders 58 Fees and invoice

Quantitative determinations 7 AD Automated differential count 7 AK Therapeutic drug monitoring 8 AM Ammonia 8 BG Blood gas 8 BI Neonatal bilirubin 9 CM Cardiac markers 9 CS Immunosuppressives 10 DD D-Dimer 10 DT CD Transferrin 10 EG Ethylglucuronide 11 ET Ethanol 11 FD Faeces diagnostics 11 GH Glycated hemoglobin 12 GL Glucose („wet“ and „POCT/dry chemistry“) (special offer for small laboratories) 12 GR Coagulation 13 HA Hematology - Full blood count 13 HM Hormones - group 1 14 HP Hormones - group 2 14 IG Serum proteins 15 IS Immunophenotyping 15 KL Clinical chemical analytes in cerebrospinal fluid (CSF) 16 KS Clinical chemical analytes in serum „wet chemistry“ 16 KU Clinical chemical analytes in urine 17 LP Lipoproteins 17 NBS Newborn screening 18 OH Hemoglobin derivates 18 OS Bone metabolism 18 PH Photometer control 19 RE Reticulocytes 19 RF Rheumatoid factors 20 SA Thyroid antibodies 20 SD Pregnancy diagnostic 21 SP Trace elements in urine 21 SV Saliva diagnostic 21 SW Sweat analysis 22 TH Thrombophilia screening (cooperation with the Dutch organization ECAT) 23 TM Tumor markers group 1 23 TMX Tumor markers group 2 24 TR Clinical chemical analytes in serum „dry chemistry“ 24 VT Vitamins and analgesics 25 ZL Cell count in cerebrospinal fluid (CSF) 25 ZY Cytokines

Qualitative determinations 26 AI Antinuclear antibodies 26 AL Allergology 27 BorrBimm Anti-Borrelia burgdorferi 27 CMVimm CMV serology 27 DF Hematology - Differential blood count 28 DS Drug screening in urine 28 EBVimm Epstein-Barr-Virus serology 29 HAVimm HAV serology 29 HBVimm1 Minor HBV serology 29 HBVimm2 Major HBV serology 30 HCVimm HCV serology

List of contents

4 List of contents

List of contents 30 HerpVimm Herpes viruses serology 30 HIVimm HIV serology 31 HS Urinary calculus 31 HTLVimm Human T-lymphotropic virus 31 IA Immunohematology automated 32 IH Immunohematology Major (extended offer) 32 IM Immunohematology Minor (basic program) 33 KUST Clinical chemistry from urine, qualitative test strip and pregnancy test 33 MaMuImm Morbilli and mumps serology 34 OB Oligoclonal bands in cerebrospinal fluid (CSF) 34 pvB19imm pvB19 serology 34 RoetLimm Anti-Rubella Virus 35 SX Systematic toxicologic analysis 35 ToxoGimm Anti-Toxoplasma gondii 35 TrepPimm Anti-Treponema pallidum 36 TX Toxicologic analyses 36 US Urine sediment 37 VariAimm Various immunological analytes 37 ZZ Cerebrospinal fluid cytology

Direct detections of pathogens 38 BA Bacteriology Major 38 BakNAT1 Genome evidence 39 BakNAT2 Genome evidence 39 BAK-TK Proficiency panel to detect bacteria in platelet concentrates 40 BM Bacteriology Minor 40 B-Stscre B-Streptococci screening 40 ChlamTra Chlamydia trachomatis AG 41 CrypCand Cryptococcus neoformans and candida albicans antigen 41 GP Gram-staining 41 HEVpcr Hepatitis E virus 42 Infl-RSV Influenca and RSV antigen evidence 42 MRGNscre MRGN screening 42 MRSAscre MRSA screening 43 MykCult Cultivation and identification of fungi 43 MykIdent Identification of fungi 43 NoroPCR Norovirus PCR 44 ParasitB Parasites in blood 44 ParasitS Parasites in stool 44 PolyVir1 Genome evidence group 1 45 PolyVir2 Genome evidence group 2 45 ToxoGen Toxoplasma gondii genome 46 TubDiag Tuberculosis diagnostics 46 VREscre VRE screening

Ejaculate investigation 47 EJ Semen (cooperation with the German society of andrology and their quality control organization QuaDeGa)

Molecular- and cytogenetic investigation 48 ctDNA circulating tumor DNA 48 DI DNA isolation 49 MG1 Molecular genetics group 1 50 MG2 Molecular genetics group 2 50 SQ DNA sequencing

Addendum 54 Index

Forms 59 Alteration of contact information (address, e-mail, fax, tel. etc.) 61 Thrombophilia screening (TH) application form 63 Application form 1 65 Application form 2 67 Application form 3 69 Application form 4 71 Application form 5 73 Application form 6 75 Application form 7

Internet / homepage / e-mail

Our websites handy address is

www.rfb.bio

Open to all interested people, you can find there: ➤ Informations about our current survey program,

➤ Evaluations of our surveys (target values, statistics, youdenplots, comments on the evaluation etc.),

➤ Informations around the surveys and the Reference Institute and,

➤ Our hemolysis database

Registered online users have (after login) more possibilities to handle the whole participation process: ➤ Online ordering / cancellation,

➤ Online data entry,

➤ PDF retrieval of: ➤ Protocol of the input of results, ➤ Certificates / evaluations, ➤ Annual summary in terms of, ➤ orders, ➤ certificates, ➤ correctness of findings.

➤ E-Mail notifications for evaluated surveys with direct links to individual evaluations.

➤ Reminder E-Mails for close survey deadlines.

➤Convenient management of multiple participation numbers by “fast user switching” with reduced login effort.

➤ Shipment options with reduced paper consumption.

➤ Summary over finished surveys per year with: ➤ passed / not rated / not passed analytes, ➤ download of complete evaluation / certificates, ➤ comment function.

➤ To register: Please use the corresponding link on our homepage or use the form on the next page.

➤ For any questions or comments please contact us via e-mail: [email protected]

Internet 5

✂

6 Registration as online user

Registration as online user

OfficeTelephone +49 228 926895-0

Fax +49 228 926895-29Internet: www.rfb.bio

E-mail: [email protected]

Dear participant,

The registration as online user can only take place, if you are applied for surveys.

Address

Institute:

Name:

Street:

Post code / City:

Country:

Telephone:

Fax:

Contact person:

Registration as online user

E-mail-address:

Date Signature

participant no

Your comment

Reference Institute for BioanalyticsOfficeFriesdorfer Straße 15353175 BonnGERMANY

For informations about our data policy please refer to our data protection declaration on page 53.

Quantitative determinations

AD Automatic differential count

Survey Application deadline

Sampledispatch date

survey periodfrom to

AD1/19 07.01.19 30.01.19 31.01.19 06.02.19AD2/19 08.04.19 08.05.19 09.05.19 15.05.19AD3/19 24.06.19 17.07.19 18.07.19 24.07.19AD4/19 14.10.19 06.11.19 07.11.19 13.11.19

€ Fee for each survey, net prices plus VAT, plus special freight

each additional required pair of samples30,00 €25,00 €

➤ Sample materialblood, liquid, 2 samples each 1 ml

➤ Analytesdifferential count of the leukocytes with automatic systemsintended not for use overseas

➤ InformationThe samples have only a very limited stability and are sent to you therefore with an express or parcel courier. The costs will be charged additionally.The registration form for this survey you will find on page 63/64.

AK Therapeutic drug monitoring


Sampledispatch date


AK1/19 17.12.18 09.01.19 14.01.19 26.01.19AK2/19 01.04.19 16.04.19 23.04.19 04.05.19AK3/19 17.06.19 03.07.19 08.07.19 20.07.19AK4/19 09.09.19 25.09.19 30.09.19 12.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATmaterial fee additional set

set 1set 2set 3

set 1 + 2set 1 + 3set 2 + 3

set 1 + 2 + 3

56,00 €47,00 €34,00 €84,00 €70,00 €61,00 €

108,00 €

36,00 €36,00 €20,00 €

➤ Sample materialserum, lyophilized set 1: 2 samples each 3 ml

set 2: 2 samples each 3 mlset 3: 2 samples each 2 ml

➤ Analytesset 1carbamazepinedigoxinethosuximidelithiumphenobarbital

phenytoinprimidonetheophyllinevalproic acid

set 2amikacincaffeindigitoxingentamycin

methotrexate tobramycinvancomycin

set 3piperacillinLinezolidMeropenem

➤ InformationThe registration form for this survey you will find on page 63/64.

Surveys of the RfB 7

B1

AM Ammonia


Sampledispatch date


AM1/19 19.11.18 09.01.19 14.01.19 26.01.19AM2/19 18.03.19 03.04.19 08.04.19 20.04.19AM3/19 17.06.19 03.07.19 08.07.19 20.07.19AM4/19 09.09.19 25.09.19 30.09.19 12.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VAT


➤ Sample materialserum or control, liquid, 2 samples each 1-3 ml (depending on the manufacturer of samples)

➤ Analyteammonia


BG Blood gas


Sampledispatch date


BG1/19 02.01.19 16.01.19 21.01.19 02.02.19BG2/19 25.03.19 10.04.19 15.04.19 27.04.19BG3/19 08.07.19 24.07.19 29.07.19 10.08.19BG4/19 30.09.19 16.10.19 21.10.19 02.11.19



➤ Sample materialgas equilibrated solution, liquid, 2 ampoules each 2 ml

➤ AnalytespHpCO2pO2

calcium, ionizedchlorideglucose

potassiumlactatesodium


BI Neonatal bilirubin


Sampledispatch date


BI1/19 17.12.18 09.01.19 14.01.19 26.01.19BI2/19 25.03.19 10.04.19 15.04.19 27.04.19BI3/19 24.06.19 10.07.19 15.07.19 27.07.19BI4/19 23.09.19 09.10.19 14.10.19 26.10.19



➤ Sample materialserum, lyophilized, 2 samples each 2 ml

8 Surveys of the RfB

➤ Analytesbilirubin, total bilirubin, conjugated

bilirubin, directbilirubin, unconjugatedbilirubin, indirect

➤ InformationThese specimens contain concentrations of bilirubin which are characteristic in neonatology.The registration form for this survey you will find on page 63/64.

CM Cardiac markers


Sampledispatch date


CM1/19 14.01.19 30.01.19 04.02.19 16.02.19CM2/19 08.04.19 24.04.19 29.04.19 11.05.19CM3/19 24.06.19 10.07.19 15.07.19 27.07.19CM4/19 09.09.19 25.09.19 30.09.19 12.10.19


set 1set 2

set 1 and set 2

49,00 €34,00 €75,00 €

29,00 €27,00 €56,00 €

➤ Sample materialserum, lyophilizedserum, lyophilized

set 1: 2 samples each 2 mlset 2: 2 samples each 1 mlIf you order only set 2 you will receive only samples for the determination of BNP.

➤ Analytesset 1CK-MB mass + activitymyoglobine

NT-proBNPcardiac troponin I

cardiac troponin Ttest strips

set 2BNP


CS Immunosuppressives


Sampledispatch date


CS1/19 21.01.19 12.02.19 13.02.19 23.02.19CS2/19 05.08.19 27.08.19 28.08.19 07.09.19


set 1set 2

set 1 and set 2

41,00 €36,00 €56,00 €

28,00 €15,00 €43,00 €

➤ Sample materialhemolyzed bloodhemolyzed blood

set 1: 4 samples each 1,5 mlset 2: 2 samples each 1,5 ml

➤ Analytesset 1cyclosporinesirolimustacrolimus

set 2everolimus



B1

DD D-Dimer


Sampledispatch date


DD1/19 07.01.19 23.01.19 28.01.19 09.02.19DD2/19 15.04.19 30.04.19 06.05.19 18.05.19DD3/19 01.07.19 17.07.19 22.07.19 03.08.19DD4/19 30.09.19 16.10.19 21.10.19 02.11.19



➤ Sample materialplasma, lyophilized, 2 samples each 1 ml

➤ Analytequantiative: D-dimer D-dimer (FEU)

qualitative: D-dimer


DT CD Transferrin


Sampledispatch date


DT1/19 18.02.19 06.03.19 11.03.19 30.03.19DT2/19 29.07.19 14.08.19 19.08.19 07.09.19



➤ Sample materialserum, lyophilized, 2 samples each 0,5 ml

➤ AnalyteCDT (Carbohydrate Deficient Transferrin)

➤ InformationCDT represents a so-called alcoholic marker which is employed in the determination of alcohol abuse.The registration form for this survey you will find on page 63/64.

EG Ethylglucuronide


Sampledispatch date


EG1/19 21.01.19 10.04.19 15.04.19 27.04.19EG2/19 27.05.19 18.09.19 23.09.19 05.10.19



➤ Sample materialurine, lyophilized, 2 samples each 1 ml

➤ AnalyteEthylglucuronide



ET Ethanol


Sampledispatch date


ET1/19 07.01.19 23.01.19 28.01.19 09.02.19ET2/19 01.04.19 16.04.19 23.04.19 04.05.19ET3/19 08.07.19 24.07.19 29.07.19 10.08.19ET4/19 30.09.19 16.10.19 21.10.19 02.11.19



➤ Sample materialserum, liquid, 2 samples each 2 ml

➤ Analyteethanol


FD Faeces diagnostics


Sampledispatch date


FD1/19 15.04.19 22.05.19 27.05.19 08.06.19FD2/19 15.07.19 23.10.19 28.10.19 09.11.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VAT evaluation pair analytical results

1-234

each additional required pair of samples

40,00 €58,00 €76,00 €38,00 €

➤ Sample materialstool, lyophilized, 2 samples each 0,2 ml

➤ AnalytesHemoglobin iFOBT assay (quantitative, qualitative)Hemoglobin / haptoglobin complex (quantitative, qualitative)

Elastase -1 (quantitative, qualitative)Calprotectin (quantitative, qualitative)


GH Glycated hemoglobin


Sampledispatch date


GH1/19 14.01.19 22.01.19 23.01.19 30.01.19GH2/19 18.03.19 02.04.19 03.04.19 10.04.19GH3/19 24.06.19 09.07.19 10.07.19 17.07.19GH4/19 30.09.19 15.10.19 16.10.19 23.10.19



➤ Sample materialfull blood or hemolysate, 2 samples each 0,3 ml


B1

➤ AnalytesHb A1c


GL Glucose (wet and POCT/dry chemistry)


Sampledispatch date


GL1/19 26.11.18 12.12.18 02.01.19 12.01.19GL2/19 04.03.19 20.03.19 25.03.19 06.04.19GL3/19 03.06.19 18.06.19 24.06.19 06.07.19GL4/19 02.09.19 18.09.19 23.09.19 05.10.19



➤ Sample materialserum, lyophilized, 2 samples each 2 mlIf special blood specimens are available we will use them instead of serum.

➤ Analyteglucose

➤ InformationThe survey „Glucose“ is offered to laboratories which determine glucose only. If further clinical chemistry analytes are to be determined, participation in a „Clinical chemical analytes in serum“ survey is suggested (KS or TR).This survey is especially recommended for laboratories and practices using glucose measuring instruments, which operate on the basis of pre-portioned reagents (Unit-use) (e. g. Accucheck, Accutrend, Ascensia Elite, HemoCue etc.).The registration form for this survey you will find on page 63/64.

GR Coagulation


Sampledispatch date


GR1/19 07.01.19 23.01.19 28.01.19 09.02.19GR2/19 15.04.19 30.04.19 06.05.19 18.05.19GR3/19 01.07.19 17.07.19 22.07.19 03.08.19GR4/19 30.09.19 16.10.19 21.10.19 02.11.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATevaluation pair analytical results

1-56-10

each additional 5 pairs of analytical results each additional required pair of samples

54,00 €61,50 €

7,50 €34,00 €

➤ Sample materialplasma, lyophilized, 2 samples each 1 ml

➤ Analytesantithrombin III (AT III), activityfibrinogenINRprothrombin time (PT, Quick)activated partial thromboplastin time (aPTT)thrombin time

factor II factor Vfactor VIIfactor VIIIfactor IX

factor Xfactor XIfactor XIIfactor XIII



HA Hematology - Full blood count


Sampledispatch date


HA1/19 07.01.19 29.01.19 30.01.19 06.02.19HA2/19 08.04.19 07.05.19 08.05.19 15.05.19HA3/19 24.06.19 16.07.19 17.07.19 24.07.19HA4/19 16.09.19 08.10.19 09.10.19 16.10.19



➤ Sample materialprepared blood, liquid, 2 samples each 2 ml

➤ Analyteserythrocyte counthematocrit (packed cell volume)hemoglobin

leukocyte countMCHMCHC

MCVplatelet count

➤ InformationFor the automatic differential count of the leukocytes please order the survey AD.These samples can not be used for the investigation with QBC systems.The registration form for this survey you will find on page 65/66.

HM Hormones - Group 1


Sampledispatch date


HM1/19 10.12.18 02.01.19 07.01.19 26.01.19HM2/19 18.03.19 03.04.19 08.04.19 27.04.19HM3/19 11.06.19 26.06.19 01.07.19 20.07.19HM4/19 26.08.19 11.09.19 16.09.19 05.10.19


1-45-8

each additional 4 pairs analytical results each additional required pair of samples

50,00 €54,00 €

4,00 €33,00 €


➤ AnalytesaldosteronecortisolDHEA-S

estradiol-17βferritinprogesterone

17-OH-progesteroneTBGtestosterone

T3, freeT3, totalT4, free

T4, totalTSH

➤ Informationsteroid hormones, thyroid hormonesFree estriol can be determined only in the survey for pregnancy diagnostic (SD).The registration form for this survey you will find on page 65/66.


B1

HP Hormones - Group 2


Sampledispatch date


HP1/19 10.12.18 02.01.19 07.01.19 26.01.19HP2/19 18.03.19 03.04.19 08.04.19 27.04.19HP3/19 11.06.19 26.06.19 01.07.19 20.07.19HP4/19 26.08.19 11.09.19 16.09.19 05.10.19


1-23-6


35,00 €39,00 €

4,00 €23,00 €


➤ Analytesferritinfolic acidFSHhGH (somatotropin/growth hormone)

IGF-1IGFBP-3insulinLH

parathyroid hormoneprolactinrenin / renin-activity

SHBGvitamin B12


IG Serum proteins


Sampledispatch date


IG1/19 17.12.18 08.01.19 14.01.19 26.01.19IG2/19 01.04.19 15.04.19 23.04.19 04.05.19IG3/19 17.06.19 02.07.19 08.07.19 20.07.19IG4/19 09.09.19 24.09.19 30.09.19 12.10.19


1-23-6


45,00 €49,00 €

4,00 €33,00 €

➤ Sample materialserum, liquid, 2 samples each 1 ml

➤ Analytesalbuminα1-antitrypsinα1-glycoproteincoeruloplasmin

CRPcystatin CC3 complementC4 complement

haptoglobinIgAIgEIgG

IgMprealbumintransferrinsol. transferrin receptorCRP qualitative



IS Immunophenotyping (flow cytometry)


Sampledispatch date


IS1/19 28.01.19 18.02.19 19.02.19 21.02.19IS2/19 19.08.19 09.09.19 10.09.19 12.09.19

€ Fee for each survey, net prices plus VAT, plus special freight


➤ Sample materialprepared blood samples, liquid, 2 samples with different analyte concentrations each about 2 ml

➤ AnalytesB-cellsleukocyte countlymphocyte count

NK-cellsT-cellsT-helper cells

T-suppressor cellsHLA-B27

➤ InformationThe samples have only a very limited stability and are sent to you therefore with an express or parcel courier. The costs will be charged additionally.The registration form for this survey you will find on page 65/66.

KL Clinical chemical analytes in cerebrospinal fluid (CSF)


Sampledispatch date


KL1/19 02.01.19 16.01.19 21.01.19 02.02.19KL2/19 11.03.19 27.03.19 01.04.19 13.04.19

KL3/19 03.06.19 18.06.19 24.06.19 06.07.19

KL4/19 02.09.19 18.09.19 23.09.19 05.10.19


each additional required set of samples44,00 €24,00 €

➤ Sample materialCSF, lyophilizedserum, lyophilized

2 samples each 3 ml 2 samples each 1 ml

➤ Analytesalbumintotal protein

glucoselactate

IgGIgA

IgMquotients

indicesdiagnoses

➤ InformationThe additional serum samples serve to calculate the corresponding quotients.The registration form for this survey you will find on page 65/66.


B1

KS Clinical chemical analytes in serum „wet chemistry“


Sampledispatch date


KS1/19 03.12.18 02.01.19 07.01.19 12.01.19KS2/19 21.01.19 06.02.19 11.02.19 16.02.19KS3/19 11.03.19 27.03.19 01.04.19 06.04.19KS4/19 23.04.19 08.05.19 13.05.19 18.05.19KS5/19 11.06.19 26.06.19 01.07.19 06.07.19KS6/19 22.07.19 07.08.19 12.08.19 17.08.19KS7/19 09.09.19 25.09.19 30.09.19 05.10.19KS8/19 21.10.19 06.11.19 11.11.19 16.11.19

€ Fee for each survey inclusive sample material, net prices plus VATevaluation pair analytical results

1-89-12


44,00 €47,00 €

3,00 €23,00 €


➤ Analytesα-amylaseα-HBDH, lactate dehydrogenase-1-isoenzymealbumin (chem.)albumin (elektrophoresis)alkaline phosphataseALT, alanine aminotransferase (GPT)AST, aspartate aminotransferase (GOT)bilirubin, directbilirubin, totalcalciumcalcium, ionizedchloridecholesterolcholinesterase

CK, creatine kinaseironγ-globulin (electrophoresis)γ-GT, L-γ-glutamyl-transferaseprotein, totalGLDH, glutamate dehydrogenaseglucoseuric acidureapotassiumcreatininecopperlactateLDH, lactate dehydrogenase

lipaselithiummagnesiumsodiumosmolalitypancreatic amylasephosphorus, inorganicacid phosphatase, totalacid phosphatase, prostate (only enzyme activity)triglycerides


KU Clinical chemical analytes in urine


Sampledispatch date


KU1/19 02.01.19 16.01.19 21.01.19 02.02.19KU2/19 11.03.19 27.03.19 01.04.19 13.04.19KU3/19 03.06.19 18.06.19 24.06.19 06.07.19KU4/19 02.09.19 18.09.19 23.09.19 05.10.19





➤ Analytesalbuminα1-microglobulinα2-macroglobulincalcium, totalchloridecitrateprotein, totalglucoseuric acid

ureaIgGpotassiumcreatininemagnesiumsodiumosmolatityoxalatephosphorus, inorganic

Test stripbilirubinketonepHproteinglucosehemoglobinleukocytesmicroalbumin

nitritespecific gravityurobilinogen

➤ InformationThe test for pregnancy from urine will be offered in a separate survey. Please see at KUST.A diagnosis of proteinuria can also be given. Clinical information will be available.The registration form for this survey you will find on page 65/66.

LP Lipoproteins


Sampledispatch date


LP1/19 21.01.19 06.02.19 11.02.19 23.02.19LP2/19 08.04.19 24.04.19 29.04.19 11.05.19LP3/19 24.06.19 10.07.19 15.07.19 27.07.19LP4/19 16.09.19 30.09.19 07.10.19 19.10.19




➤ Analytesapolipoproteins (A, B)cholesterolHDL

homocysteineLDL

lipoprotein(a)triglycerides


NBS Newborn screening


Sampledispatch date


NBS1/19 07.01.19 23.01.19 28.01.19 16.02.19NBS2/19 25.03.19 10.04.19 15.04.19 04.05.19NBS3/19 17.06.19 03.07.19 08.07.19 27.07.19NBS4/19 02.09.19 18.09.19 23.09.19 12.10.19



➤ Sample materialfilter papers, each with 2 dried blood spots

➤ AnalytesTSH 17-OH-progesteroneIRTPAP



B1

OH Hemoglobin derivates


Sampledispatch date


OH1/19 02.01.19 16.01.19 21.01.19 02.02.19OH2/19 25.03.19 10.04.19 15.04.19 27.04.19OH3/19 08.07.19 24.07.19 29.07.19 10.08.19OH4/19 30.09.19 16.10.19 21.10.19 02.11.19



➤ Sample materialhemolysate, 2 samples each 0,5 ml

➤ Analyteshemoglobin (total) oxyhemoglobin (HbO2) carboxyhemoglobin (COHb) methemoglobin (metHb)


OS Bone metabolism


Sampledispatch date


OS1/19 21.01.19 10.04.19 15.04.19 27.04.19OS2/19 13.05.19 04.09.19 09.09.19 21.09.19




➤ Analyteosteocalcin, bone specific alkaline phosphatase (BAP), CTx (CrossLaps) and P1NP


PH Photometer control


Sampledispatch date


PH1/19 14.01.19 30.01.19 04.02.19 16.02.19PH2/19 12.08.19 28.08.19 02.09.19 14.09.19



➤ Sample materialwatery coloured solutions, 6 ampoules each 10 ml

➤ Wave lengths260 nm280 nm334 nm

340 nm365 / 366 nm405 nm

546 nm560 nm


➤ InformationThe participant measures the absorption of the coloured solutions.The survey is an instrument control and can also aid in detecting the smaller inaccuracies of a photometer before they are identified in analyses results. Only the wave lengths listed can be tested.The registration form for this survey you will find on page 65/66.

RE Reticulocytes


Sampledispatch date


RE1/19 15.10.18 29.01.19 30.01.19 06.02.19RE2/19 08.04.19 07.05.19 08.05.19 15.05.19RE3/19 24.06.19 16.07.19 17.07.19 24.07.19RE4/19 16.09.19 08.10.19 09.10.19 16.10.19



➤ Sample materialblood preparation, liquid, 2 samples each about 1 ml

➤ Analytesreticulocyte count

➤ InformationThe samples can be used for a counting by visual microscopy or by automated cell counting.The registration form for this survey you will find on page 65/66.

RF Rheumatoid factors


Sampledispatch date


RF1/19 04.02.19 20.02.19 25.02.19 09.03.19RF2/19 23.04.19 08.05.19 13.05.19 25.05.19RF3/19 15.07.19 31.07.19 05.08.19 17.08.19RF4/19 16.09.19 30.09.19 07.10.19 19.10.19


set 1set 2

set 1 and set 2

37,00 €25,00 €51,00 €

22,00 €18,50 €40,50 €


➤ Analytes set 1rheumatoid factors anti-CCP-Ab (anti-cyclic citrullinated peptide antibodies)IgA-RFIgG-RFIgM-RFset 2anti-streptolysin O

qualitative and quantitative

qualitative and quantitative➤ Information

The registration form for this survey you will find on page 65/66.


B1

SA Thyroid antibodies


Sampledispatch date


SA1/19 10.12.18 06.03.19 11.03.19 23.03.19SA2/19 20.05.19 07.08.19 12.08.19 24.08.19




➤ AnalytesTSH-R Ab: thyrotropin-receptor antibodies (TR Ab)TPO Ab: thyroid peroxidase antibodies (TPO Ab)TG Ab: thyroglobulin antibodies (TG Ab)

➤ Information The registration form for this survey you will find on page 65/66.

SD Pregnancy diagnostic


Sampledispatch date


SD1/19 10.12.18 02.01.19 07.01.19 26.01.19SD2/19 18.03.19 03.04.19 08.04.19 27.04.19SD3/19 11.06.19 26.06.19 01.07.19 20.07.19SD4/19 26.08.19 11.09.19 16.09.19 05.10.19


set 1set 2

set 1 and set 2

41,00 €37,00 €69,00 €

22,00 €25,00 €47,00 €

➤ Sample materialserum, lyophilized set 1: 2 samples each 2 ml

set 2: 2 samples each 1 ml In set 2 (free estriol) nativ, human samples are used.

➤ Analytes set 1AFPanti-Müllerian hormone (AMH)hCGfree β-hCGPAPP-Aset 2free estriol

➤ InformationThe samples offered in this survey will contain analytes in a concentration range relevant for pregnancy diagnostic.For the qualitative test for pregnancy please order the survey KUST.The registration form for this survey you will find on page 67/68.


SP Trace elements in urine


Sampledispatch date


SP1/19 04.02.19 20.02.19 25.02.19 16.03.19SP2/19 22.07.19 07.08.19 12.08.19 31.08.19



➤ Sample materialurine, lyophilized, 2 samples each 10 (2 × 5) ml

➤ Analytesaluminiumarseniccadmium

chromiumcobaltcopper

fluorideironlead

manganesemercurynickel

seleniumzinc


SV Saliva diagnostic


Sampledispatch date


SV1/19 21.01.19 10.04.19 15.04.19 27.04.19SV2/19 13.05.19 04.09.19 09.09.19 21.09.19



➤ Sample materialsaliva preparation, liquid or lyophilized, 2 samples each 2 ml

➤ Analytecortisol, 17-OH-progesterone


SW Sweat analysis


Sampledispatch date


SW1/19 04.03.19 20.03.19 25.03.19 06.04.19SW2/19 29.07.19 14.08.19 19.08.19 31.08.19



➤ Sample materialsweat preparation, liquid or lyophilized, 2 samples each 1 ml

➤ Analyteschloride, conductivity



B1

TH Thrombophilia screening


Dispatch date Closing date

TH1/19

09.12.18

05.03.19 02.04.19TH2/19 04.06.19 02.07.19TH3/19 27.08.19 24.09.19TH4/19 12.11.19 10.12.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATPlease note, that you can order only all the two resp. four surveys of the year together!An order of a single survey (one/two times a year) is not possible in this case.

Result submission via internet/report internet, annual subscription feeResult submission via internet/report internet+post, annual subscription fee

The following prices are valid in each case for all four surveys: Thrombophilia module I Thrombophilia module II

Lupus Anticoagulant / Antiphospholipid AntibodiesVon Willebrand Faktor module (antigen, activity, collagen binding, multimers, Factor VIII)

ADAMTS-13 - I (activity and antigen)Factor XIII (activity and antigen)

Fibrinolysis parameters I (Plasminogen, Antiplasmin) Fibrinolysis parameters II (t-PA, PAI-1)

Unfractionated Heparin Monitoring (anti-Xa)Low-Molecular Weight Heparin Monitoring (anti-Xa)

The following prices are valid in each case for all two surveys:

Faktor VIII InhibitorThrombin Generation TestADAMTS-13 - II (inhibitor)

Factor IX Inhibitor

The following prices are valid in each case for one survey HIT - Immunological assays

Fee

112,50 €200,00 €

345,00 €140,00 €157,50 €135,00 €180,00 €127,50 €125,50 €125,50 €112,50 €112,50 €

165,00 €137,50 €115,00 €165,00 €

95,00 €

➤ Sample materialplasma or serum, human, lyophilized, ca. 0,5 - 1 ml (1 or 2 sample(s) each)

➤ Analytes 4 per year: TH1/19, TH2/19, TH3/19, TH4/19Thrombophilia module IIncludes an annual report on the long-term evaluation of test results. Antithrombin (activity and antigen) Protein S activity Protein C (activity [chromogenic and clotting] and antigen) Protein S antigen (free and total)Thrombophilia module II (APC Resistance)Lupus Anticoagulant / Antiphospholipide AntibodiesVon Willebrand Factor module (antigen, activity, collagen binding, multimers)ADAMTS-13 - I (activity and antigen)Factor XIII (activity and antigen)Fibrinolysis parameters I (Plasminogen, Antiplasmin)Fibrinolysis parameters II (t-PA, PAI-1)Unfractionated Heparin Monitoring (anti-Xa)Low-Molecular Weight heparin Monitoring (anti-Xa)

➤ Analytes 2 per year: Faktor VIII Inhibitor (TH2/19 + TH4/19)Thrombin Generation Test (TH2/19 + TH4/19)ADAMTS-13 - II (antibodies) (TH2/19 + TH4/19)Faktor IX Inhibitor (TH1/19 + TH3/19)

➤ Analytes 1 per year: HIT - I Immunological assays (TH3/19)


➤ InformationIn cooperation with the Dutch organization ECAT the Reference Institute for Bioanalytics provides special surveys for thrombophilia screening.The preparation of the survey material, what is in most cases native patient material, the mailing of samples and the evaluation is done by our colleagues from the Netherlands.Sample materialThe samples will consist of lyophilized human plasma or serum with different volume (0,5 to 1 ml).Per analyte or set of analytes you will get one or two sample(s).Please note our deadline for the order and please use for the applications the special application form! We can not accept cancellations during the annual programme.The result submission is only possible via internet.


TM Tumor markers group 1


Sampledispatch date


TM1/19 10.12.18 02.01.19 07.01.19 26.01.19TM2/19 18.03.19 03.04.19 08.04.19 27.04.19TM3/19 11.06.19 26.06.19 01.07.19 20.07.19TM4/19 26.08.19 11.09.19 16.09.19 05.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VAT evaluation pair analytical results

1-23-6


43,00 €48,00 €

5,00 €33,00 €

➤ Sample materialserum, lyophilized, 2 samples each 2,5 ml

➤ AnalytesAFPCA 15-3CA 19-9CA 72-4CA 125

calcitoninCEACYFRAhCGNSE

β-2-microglobulinPAP (only mass concentration, no enzyme activity)PSAcPSA (complexed PSA)PSA free

S-100SCCthyroglobulinTPATPS


TMX Tumor markers group 2


Sampledispatch date


TMX1/19 10.12.18 02.01.19 07.01.19 26.01.19TMX2/19 18.03.19 03.04.19 08.04.19 27.04.19TMX3/19 11.06.19 26.06.19 01.07.19 20.07.19TMX4/19 26.08.19 11.09.19 16.09.19 05.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VAT each additional required pair of samples

34,00 €24,00 €


➤ Analyteschromogranin A human epidermal growth factor receptor 2 CA 50



B1

TR Clinical chemical analytes in serum „dry chemistry“


Sampledispatch date


TR1/19 26.11.18 12.12.18 02.01.19 12.01.19TR2/19 04.03.19 20.03.19 25.03.19 06.04.19TR3/19 17.06.19 03.07.19 08.07.19 20.07.19TR4/19 14.10.19 29.10.19 04.11.19 16.11.19


1-89-12


41,00 €45,00 €

4,00 €22,00 €


➤ Analytesα-amylasealbuminalkaline phosphataseALT, alanine-aminotransferase (GPT) AST, aspartate-aminotransferase (GOT)bilirubin, totalcalciumchloridecholesterolcholinesteraseCK, creatine kinase

ironγ-GT, L-γ-glutamyl transferaseprotein, totalglucoseuric acidureapotassiumcreatininelactateLDH, lactate dehydrogenaselipase

lithiummagnesiumsodiumpancreatic amylasephosphorus inorganictriglycerides

➤ InformationThis offer is addressed to users of Vitros and Reflotron systems and other „dry chemistry“ instruments.The registration form for this survey you will find on page 67/68.

VT Vitamins and analgesics


Sampledispatch date


VT1/19 18.02.19 06.03.19 11.03.19 23.03.19VT2/19 22.07.19 07.08.19 12.08.19 24.08.19




➤ Analytesvitamin A (retinol)vitamin B6 (pyridoxal-5-phosphate)vitamin B12 (cyanocobalamin)vitamin B1 (thiamine)vitamin D 25-OH-D3 (25-OH-cholecalciferol), 25-(OH)2-D3 and 25-OH-vitamin D totalvitamin E (tocopherol)

folic acidsalicylic acidparacetamol / acetaminophen



ZL Cell count in cerebrospinal fluid (CSF)


Sampledispatch date


ZL1/19 05.11.18 05.03.19 11.03.19 16.03.19ZL2/19 17.06.19 18.09.19 23.09.19 28.09.19



➤ Sample materialcerebrospinal fluid, 2 samples each about 2 ml

➤ Analyteserythrocyte countleukocyte count

➤ InformationIn this survey erythrocytes (red cells) and leukocytes (white cells) can be counted with visual methods (microscope) or electronic methods from a cerebrospinal fluid.The registration form for this survey you will find on page 67/68.

ZY Cytokines


Sampledispatch date


ZY1/19 04.02.19 20.02.19 25.02.19 09.03.19ZY2/19 15.04.19 30.04.19 06.05.19 18.05.19ZY3/19 15.07.19 31.07.19 05.08.19 17.08.19ZY4/19 14.10.19 29.10.19 04.11.19 16.11.19




➤ AnalytesInterleukin-1 β (IL-1 β)Interleukin-6 (IL-6)Interleukin-8 (IL-8)Interleukin-10 (IL-10)

lipopolysaccharide-binding-protein (LBP)procalcitonin (PCT)soluble IL-2 receptor (sIL-2R)tumor necrosis factor-alpha (TNFα)PCT-POCTIL-6-POCT

Additionally PCT can also be determined with half quantitative procedures.



B1

Qualitative determinations

AI Antinuclear antibodies


Sampledispatch date


AI1/19 17.12.18 26.02.19 04.03.19 16.03.19

AI2/19 01.07.19 04.09.19 09.09.19 21.09.19


set 1set 2

set 1 and set 2

74,00 €71,00 €

128,00 €

42,00 €42,00 €84,00 €

➤ Sample materialserum/plasma, lyophilized set 1: about 6 samples each 0,5 ml

set 2: about 6 samples each 0,5 ml➤ Analytes

set 1ANA (antinuclear ab)ENA (extractable antinuclear ab) ds-DNA-abANCA (antineutrophil cytoplasmatic ab)

set 2AMA (antimitochondrial ab)SMA (smooth muscle ab)LKM-1 (liver-kidney-microsomes)GBM (glomerular base membran ab) Antiphospholipide abCeliak disease ab Onconeural ab


AL Allergology


Sampledispatch date


AL1/19 28.01.19 13.02.19 18.02.19 02.03.19AL2/19 23.04.19 08.05.19 13.05.19 25.05.19AL3/19 15.07.19 31.07.19 05.08.19 17.08.19AL4/19 16.09.19 30.09.19 07.10.19 19.10.19


set 1set 2

set 1 and set 2

28,00 €59,00 €69,00 €

11,00 €38,00 €49,00 €

➤ Sample materialserum, lyophilized set 1: 2 samples each 1 ml for IgE totalserum, lyophilized set 2: 2 samples each 1 ml for specific IgE antibodies The volume of the specimens in some cases may be different depending on the producer.

The samples for the determination of specific IgE-antibodies (set 2) contain allergens from inhallation, food and insects. Expected the following allergens will be offered (changes possible):AL1/19: birch (t3), mites (d1), peanut (f13), honey bee venom (i1), wheat flour (f4), apple (f49)AL2/19: common ragweed (w1), dog danders (e5), strawberry (f44), wasp venom (i3), hazel (t4)AL3/19: birch (t3), mites (d1), peanut (f13), honey bee venom (i1), rye flour (f5), mugwort (w6)AL4/19: blue grass (g8), cat epithelia (e1), celery (f85), wasp venom (i3), banana (f92), kiwi (f84)

➤ AnalytesIgE specific IgE antibodies

➤ InformationFrom a large number of possible IgE-antibodies we will supply for investigation changing groups of antibodies. It is also possible to give a classification of the stage of sensibilisation.The registration form for this survey you will find on page 69/70.


BorrBimm Anti-Borrelia burgdorferi


Sampledispatch date


BorrBimm1/19 01.04.19 15.05.19 20.05.19 01.06.19BorrBimm2/19 19.08.19 30.09.19 07.10.19 19.10.19



➤ Sample material4 liquid samples of defibrinated plasma or serum

➤ AnalytesAnti-Borrelia burgdorferi IgG Anti-Borrelia burgdorferi IgM Anti-Borrelia burgdorferi total

➤ InformationFor deliveries abroad additional freight charges will be invoiced possibly.The registration form for this survey you will find on page 69/70.

CMVimm CMV serology


Sampledispatch date


CMVimm1/19 07.01.19 13.03.19 18.03.19 30.03.19CMVimm2/19 24.06.19 28.08.19 02.09.19 14.09.19




➤ AnalytesAnti-CMV IgG + total Anti-CMV IgM


DF Hematology - Differential blood count


Sampledispatch date


DF1/19 07.01.19 23.01.19 28.01.19 09.02.19DF2/19 01.04.19 16.04.19 23.04.19 04.05.19DF3/19 01.07.19 17.07.19 22.07.19 03.08.19DF4/19 09.09.19 25.09.19 30.09.19 12.10.19



➤ Sample material2 blood slides, stained Pappenheim. Both slides are normally also available by smears of virtual microscopy.



B2

DS Drug screening in urine


Sampledispatch date


DS1/19 28.01.19 13.02.19 18.02.19 02.03.19DS2/19 23.04.19 08.05.19 13.05.19 25.05.19DS3/19 08.07.19 24.07.19 29.07.19 10.08.19DS4/19 14.10.19 29.10.19 04.11.19 16.11.19




➤ Analytesamphetamine etc. (about 30 different)barbiturates (about 30 different)benzodiazepines (about 50 different)cannabinoidscocain/metab.LSD

methadon/metab. methaqualon/metab.opiates/opioide (about 30 different)phencyclidinepropoxyphene tricycl. antidepressants (about 10 different)

➤ InformationPer survey the samples do contain selected drugs from a lot of substances of a drug group.The parameters specified in this ring trial are to be determined primarily by means of qualitative immunoassays. In this ring trial, users of chromatographic methods are required to merely provide the confirmatory analysis for one lead compound. We offer systematic toxicological analysis in the SX ring trial as well in the TX ring trial, which is also to be assessed clinically with a case history.The registration form for this survey you will find on page 69/70.

EBVimm Epstein-Barr-Virus serology


Sampledispatch date


EBVimm1/19 28.01.19 26.02.19 04.03.19 16.03.19EBVimm2/19 05.08.19 21.08.19 26.08.19 07.09.19



➤ Sample materialplasma, 4 samples, each 500 µl

➤ AnalytesEBV-EBNA IgGEBV-VCA IgG + IgMEBV-EA (early antigen) IgG



HAVimm HAV serology


Sampledispatch date


HAVimm1/19 07.01.19 13.03.19 18.03.19 30.03.19HAVimm2/19 24.06.19 28.08.19 02.09.19 14.09.19




➤ AnalytesAnti-HAV IgG Anti-HAV IgM Anti-HAV total


HBVimm1 HBV serology minor


Sampledispatch date


HBVimm11/19 07.01.19 13.03.19 18.03.19 30.03.19HBVimm12/19 24.06.19 28.08.19 02.09.19 14.09.19




➤ AnalytesHBsAg Anti-HBs Anti-HBc


HBVimm2 HBV serology major


Sampledispatch date


HBVimm21/19 07.01.19 13.03.19 18.03.19 30.03.19HBVimm22/19 24.06.19 28.08.19 02.09.19 14.09.19



➤ Untersuchungsmaterial4 liquid samples of defibrinated plasma or serum

➤ AnalytesHBsAgAnti-HBs

Anti-HBcHBe

Anti-HBeAnti-HBc-IgM



B2

HCVimm HCV serology


Sampledispatch date


HCVimm1/19 07.01.19 13.03.19 18.03.19 30.03.19HCVimm2/19 24.06.19 28.08.19 02.09.19 14.09.19




➤ AnalytesAnti-HCV IgG + IgM


HerpVimm Herpes viruses serology


Sampledispatch date


HerpVimm1/19 28.01.19 26.02.19 04.03.19 16.03.19HerpVimm2/19 05.08.19 21.08.19 26.08.19 07.09.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATset 1set 2

set 1 + 2each additional required set of samples

80,00 €80,00 €

130,00 €44,00 €


➤ AnalytesSet 1: HSV 1/2 IgG + IgMSet 2: VZV IgG + IgM


HIVimm HIV serology


Sampledispatch date


HIVimm1/19 07.01.19 13.03.19 18.03.19 30.03.19HIVimm2/19 24.06.19 28.08.19 02.09.19 14.09.19




➤ AnalytesAnti-HIV 1/2 Ak / Ag(p24)



HS Urinary calculus


Sampledispatch date


HS1/19 28.01.19 13.02.19 18.02.19 02.03.19HS2/19 22.07.19 07.08.19 12.08.19 24.08.19



➤ Sample material4 samples of pulverized urinary calculus components, (pure, mixed, human stones)

➤ InformationTogether with the evaluation of the survey you will get IR-spectra, which you can collect for an IR-catalog.The registration form for this survey you will find on page 69/70.

HTLVimm Human T-lymphotropic virus


Sampledispatch date


HTLVimm1/19 28.01.19 13.02.19 18.02.19 02.03.19HTLVimm2/19 22.07.19 07.08.19 12.08.19 24.08.19



➤ Sample materiallyophilized plasma, 4 samples

➤ AnalytesHuman T-lymphotropic virus


IA Immunohematology for automated systems


Sampledispatch date


IA1/19 14.01.19 05.02.19 06.02.19 16.02.19IA2/19 25.03.19 16.04.19 17.04.19 27.04.19IA3/19 08.07.19 30.07.19 31.07.19 10.08.19IA4/19 30.09.19 22.10.19 23.10.19 02.11.19



➤ Sample materialwhole blood, liquid 2 samples each about 3 ml

➤ AnalytesAB0-system (blood groups)A-subgroupsrhesus-factor (D-variants)rhesus-system (rhesus-formula)

Cw antigenKell antigendirect Coombs‘ testantibody test



B2

IH Immunohematology Major (extended offer)


Sampledispatch date


IH1/19 24.12.18 15.01.19 16.01.19 26.01.19IH2/19 18.03.19 09.04.19 10.04.19 20.04.19IH3/19 11.06.19 02.07.19 03.07.19 13.07.19IH4/19 16.09.19 08.10.19 09.10.19 19.10.19



➤ Sample materialerythrocyte suspension, liquidserum, liquid

2 samples each about 2 ml2 samples each about 6 ml

➤ AnalytesAB0-system (blood groups)A-subgroupsrhesus-factor (D-variants)rhesus-system (rhesus-formula)

Cw antigenKell antigendirect Coombs‘ testantibody test

antibody differentiation (serum)antibody titer

➤ InformationIn this survey additionally to the analytes of the basic program (Minor) antibody differentiation is included.The registration form for this survey you will find on page 69/70.

IM Immunohematology Minor (basic programm)


Sampledispatch date


IM1/19 24.12.18 15.01.19 16.01.19 26.01.19IM2/19 18.03.19 09.04.19 10.04.19 20.04.19IM3/19 11.06.19 02.07.19 03.07.19 13.07.19IM4/19 16.09.19 08.10.19 09.10.19 19.10.19



➤ Sample materialerythrocyte suspension, liquidserum, liquid

2 samples about 2 ml2 samples about 3 ml

➤ AnalytesAB0-system (blood groups)A-subgroupsrhesus-factor (D-variants)

rhesus-system (rhesus-formula)Cw antigen

Kell antigendirect Coombs‘ testantibody test



KUST Clinical chemistry from urine, test strip and pregnancy test, qualitative


Sampledispatch date


KUST1/19 02.01.19 16.01.19 21.01.19 02.02.19KUST2/19 11.03.19 27.03.19 01.04.19 13.04.19KUST3/19 03.06.19 18.06.19 24.06.19 06.07.19KUST4/19 02.09.19 18.09.19 23.09.19 05.10.19



➤ Sample materialurine, lyophilized qualitative, 2 samples each 5 ml, investigation for test strips

➤ AnalytesTest stripbilirubinketone

pHproteinglucose

hemoglobinleukocytesnitrite

pregnancyspecific gravityurobilinogen


MaMuImm Morbilli and mumps serology


Sampledispatch date


MaMuImm1/19 28.01.19 26.02.19 04.03.19 16.03.19MaMuImm2/19 05.08.19 21.08.19 26.08.19 07.09.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATset 1set 2

set 1 + 2each additional required set of samples

80,00 €80,00 €

130,00 €44,00 €


➤ AnalytesSet 1: morbilli IgG + IgMSet 2: mumps IgG + IgM



B2

OB Oligoclonal bands in cerebrospinal fluid (CSF)


Sampledispatch date


OB1/19 18.02.19 06.03.19 11.03.19 30.03.19OB2/19 05.08.19 21.08.19 26.08.19 14.09.19



➤ Sample materialCSF, lyophilized or liquidserum, lyophilized or liquid

2 samples each 1 ml2 samples each 1 ml

➤ Analytesoligoclonal bands in cerebrospinal fluid; diagnosis can be given.


pvB19imm Parvovirus B19 serology


Sampledispatch date


pvB19imm1/19 07.01.19 13.03.19 18.03.19 30.03.19pvB19imm2/19 24.06.19 28.08.19 02.09.19 14.09.19




➤ AnalytesAnti-Parvovirus B19 IgG + total Anti-Parvovirus B19 IgM


RoetLimm Anti-Rubella-Virus


Sampledispatch date


RoetLimm1/19 01.04.19 15.05.19 20.05.19 01.06.19RoetLimm2/19 19.08.19 30.09.19 07.10.19 19.10.19




➤ AnalytesAnti-Rubella-Virus IgG Anti-Rubella-Virus IgM Anti-Rubella-Virus total




SX Systematic toxicologic analysis


Sampledispatch date


SX1/19 25.02.19 16.04.19 23.04.19 11.05.19SX2/19 24.06.19 14.08.19 19.08.19 07.09.19




➤ AnalytesFrom a list of 30 substances, the proof of 6 - 8 substances with chromatographic methods is required in both samples


ToxoGimm Anti-Toxoplasma-gondii


Sampledispatch date


ToxoGimm1/19 01.04.19 15.05.19 20.05.19 01.06.19ToxoGimm2/19 19.08.19 30.09.19 07.10.19 19.10.19




➤ AnalytesAnti-Toxoplasma-gondii IgG Anti-Toxoplasma-gondii IgM Anti-Toxoplasma-gondii total


TrepPimm Anti-Treponema pallidum


Sampledispatch date


TrepPimm1/19 01.04.19 15.05.19 20.05.19 01.06.19TrepPimm2/19 19.08.19 30.09.19 07.10.19 19.10.19




➤ AnalytesAnti-Treponema pallidum IgG Anti-Treponema pallidum IgM Anti-Treponema pallidum total


B2

TX Toxicologic analyses


Sampledispatch date


TX1/19 28.01.19 13.02.19 18.02.19 02.03.19TX2/19 08.07.19 24.07.19 29.07.19 10.08.19



➤ Sample materialurine, lyophilized 1 sample 10 mlserum, lyophilized 1 sample 5 ml

➤ Analytesqualitative search for foreign substances in urine/serum

➤ InformationThe samples contain one or more pharmaceutical drugs or toxic agents. Together with a patient history the substances found should be interpreted. To succeed in this survey generally the use of chromatographic methods is essential.The registration form for this survey you will find on page 71/72.

US Urine sediment


Dispatch date of instruction


US1/19 18.03.19 27.03.19 01.04.19 20.04.19US2/19 16.09.19 25.09.19 30.09.19 19.10.19

€ Fee for each survey, net prices plus VAT22,00 €

➤ Sample materialweb-based, virtual microscopy of two urine sediments

➤ AnalytesQualitative and semi-quantitative determinationsMorphology



VariAimm Various immunological analytes


Sampledispatch date


VariAimm1/19 01.04.19 15.05.19 20.05.19 01.06.19VariAimm2/19 19.08.19 30.09.19 07.10.19 19.10.19




➤ AnalytesSet 1: Anti-Echinococcus IgGSet 2: Anti-Entamoeba histolytica IgGSet 3: Anti-Plasmodium totalSet 4: Anti-Schistosoma IgGSet 5: Anti-Candida albicans IgGSet 6: Anti-Streptokokken-Desoxyribonuklease IgG


ZZ Cerebrospinal fluid cytology




ZZ1/19 13.05.19 15.05.19 20.05.19 01.06.19ZZ2/19 23.09.19 25.09.19 30.09.19 12.10.19


➤ Sample materialweb-based assessment of cytospin preparation with clinical case history, 2 samples

➤ AnalytesBoth preparations are to be assessed for morphology and diagnosis



B2

Direct detection of pathogens

BA Bacteriology Major


Sampledispatch date


BA1/19 08.04.19 15.05.19 20.05.19 01.06.19BA2/19 02.09.19 09.10.19 14.10.19 26.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VAT90,00 €

➤ Sample materiallyophilized control samples, 5 strains (samples A to E)

➤ Investigation targetidentification and resistance testing


BakNAT1 Genome evidence group 1


Sampledispatch date


BakNAT11/19 11.03.19 24.04.19 29.04.19 11.05.19BakNAT12/19 19.08.19 23.10.19 28.10.19 09.11.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATone analyte

each additional required analyte150,00 €

50,00 €➤ Sample material

lyophilized DNA, 4 samples ➤ Analytes

Analyte 1: Bordetella pertussisAnalyte 2: Chlamydia pneumoniaeAnalyte 3: Mycoplasma pneumoniaeAnalyte 4: Coxiella burnetiiAnalyte 5: Francisella tularensisAnalyte 6: Legionella pneumophilaAnalyte 7: MRSAAnalyte 8: Chlamydia trachomatis




BakNAT2 Genome evidence group 2


Sampledispatch date


BakNAT21/19 11.03.19 24.04.19 29.04.19 11.05.19BakNAT22/19 19.08.19 23.10.19 28.10.19 09.11.19


each additional required analyte150,00 €


lyophilized DNA, 4 samples ➤ Analytes

Analyte 1: Salmonella entericaAnalyte 2: EHEC/STECAnalyte 3: Helicobacter pyloriAnalyte 4: Listeria monocytogenesAnalyte 5: Borrelia burgdorferiAnalyte 6: Neisseria gonorrhoeae


BAK-TK Proficiency panel to detect bacteria in platelet concentrates


Sampledispatch date


BAK-TK1/19Set 1 25.03.19 24.04.19 25.04.19 26.04.19

BAK-TK1/19Set 2 + 3 25.03.19 24.04.19 25.04.19 08.05.19

BAK-TK2/19Set 1 07.10.19 06.11.19 07.11.19 08.11.19

BAK-TK2/19Set 2 + 3 07.10.19 06.11.19 07.11.19 20.11.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATset 1set 2set 3

180,00 €180,00 €180,00 €

set 1 + 3set 2 + 3

set 1 + 2 + 3

300,00 €250,00 €350,00 €

➤ Sample materialSet 1: 6 samples of platelet concentratesSet 2 + 3: 6 samples of platelet concentrates

➤ Investigation targetSet 1: Detection with rapid methodsSet 2: Detection with culture methodsSet 3: Identification of bacteria

➤ InformationDue to German postal regulations for infectious material these surveys can not be delivered to participants from outside Germany.The registration form for this survey you will find on page 73/74.

B3

BM Bacteriology Minor


Sampledispatch date


BM1/19 08.04.19 15.05.19 20.05.19 01.06.19BM2/19 02.09.19 09.10.19 14.10.19 26.10.19


➤ Sample materiallyophilized control samples, 3 strains (samples A to C)

➤ Investigation targetidentification and resistance testing


B-Stscre B-Streptococci screening


Sampledispatch date


B-Stscre1/19 11.02.19 13.03.19 18.03.19 30.03.19B-Stscre2/19 05.08.19 04.09.19 09.09.19 21.09.19


➤ Sample material4 samples, gel smear tubes

➤ AnalytesB-Streptococci screening for cultural evidence and NAT-methods


ChlamTra Chlamydia trachomatis AG


Sampledispatch date


ChlamTra1/19 11.03.19 24.04.19 29.04.19 11.05.19ChlamTra2/19 19.08.19 23.10.19 28.10.19 09.11.19



➤ Sample materialurine, 4 samples, each 0,5 ml

➤ AnalytesChlamydia trachomatis antigen



CrypCand Cryptococcus neoformans and candida albicans antigen


Sampledispatch date


CrypCand1/19 11.03.19 24.04.19 29.04.19 11.05.19CrypCand2/19 19.08.19 23.10.19 28.10.19 09.11.19



➤ Sample materialserum, 4 samples, each 0,5 ml

➤ AnalytesCryptococcus neoformans and candida albicans antigen


GP Gram-staining


Sampledispatch date


GP1/19 14.01.19 26.02.19 04.03.19 16.03.19GP2/19 08.07.19 21.08.19 26.08.19 07.09.19



➤ Sample material2 fixed unstained smears

➤ ExaminationJudgement of staining and morphology


HEVpcr Hepatitis E virus


Sampledispatch date


HEVpcr1/19 28.01.19 13.02.19 18.02.19 02.03.19HEVpcr2/19 22.07.19 07.08.19 12.08.19 24.08.19


each additional required set of samples140,00 €


lyophilized EDTA-plasma, 4 samples ➤ Analytes

Hepatitis E virus



B3

Infl-RSV Influenca and RSV antigen evidence


Sampledispatch date


Infl-RSV1/19 18.03.19 30.04.19 06.05.19 18.05.19Infl-RSV2/19 19.08.19 23.10.19 28.10.19 09.11.19


both analytes80,00 €


NaCl-matrix, 4 samples, each 1 ml➤ Analytes

Analyte 1: Influenza AGAnalyte 2: RSV AG


MRGNscre MRGN Screening


Sampledispatch date


MRGNscre1/19 11.02.19 13.03.19 18.03.19 30.03.19MRGNscre2/19 05.08.19 04.09.19 09.09.19 21.09.19




4 samples, gel smear tubes➤ Analytes

Culture proof of MRGNMolecular diagnostic proof of Carbapenemases


MRSAsre MRSA Screening


Sampledispatch date


MRSAscre1/19 11.03.19 24.04.19 29.04.19 11.05.19MRSAscre2/19 19.08.19 23.10.19 28.10.19 09.11.19



➤ AnalytesMRSA Screening for cultural evidence and NAT-methods



MykCult Cultivation and identification of fungi


Sampledispatch date


MykCult1/19 11.03.19 24.04.19 29.04.19 18.05.19MykCult2/19 19.08.19 23.10.19 28.10.19 16.11.19




➤ AnalytesCultivation and identification of fungi


MykIdent Identification of fungi




MykIdent1/19 11.03.19 24.04.19 29.04.19 11.05.19MykIdent2/19 19.08.19 23.10.19 28.10.19 09.11.19


➤ Sample materialvirtual microscopy of 2 preparations

➤ AnalytesIdentification of fungi


NoroPCR Norovirus PCR


Sampledispatch date


NoroPCR1/19 18.02.19 03.04.19 08.04.19 20.04.19NoroPCR2/19 26.08.19 09.10.19 14.10.19 26.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATone set 150,00 €

➤ Sample materialNaCl-matrix, liquid, 4 samples

➤ AnalytesNorovirus RNA



B3

ParasitB Parasites in blood




ParasitB1/19 18.03.19 30.04.19 06.05.19 18.05.19ParasitB2/19 19.08.19 23.10.19 28.10.19 09.11.19


➤ Sample materialvirtual microscopy, one or more visual fields of 2 preparations

➤ AnalytesParasites in blood


ParasitS Parasites in stool




ParasitS1/19 18.03.19 30.04.19 06.05.19 18.05.19ParasitS2/19 19.08.19 23.10.19 28.10.19 09.11.19


➤ Sample materialvirtual microscopy, one or more visual fields of 2 preparations

➤ AnalytesParasites in stool


PolyVir1 Genome evidence group 1


Sampledispatch date


PolyVir11/19 11.02.19 14.05.19 20.05.19 01.06.19PolyVir12/19 19.08.19 23.10.19 28.10.19 09.11.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATmaterialone set

fee150,00 €

additional set75,00 €

➤ Sample material4 samples of liquid EDTA plasma, each 4 ml

➤ Analytesset 1: HAV-RNA qualitativeset 2: HBV-DNA qualitative and quantitativeset 3: HCV-RNA qualitative and quantitativeset 4: HIV1-RNA qualitative and quantitative

set 5: HIV2-RNA qualitativeset 6: WNV-RNA qualitativeset 7: CMV-DNA qualitative and quantitativeset 8: pvB19-DNA qualitative



PolyVir2 Genome evidence group 2


Sampledispatch date


PolyVir21/19 18.03.19 30.04.19 06.05.19 18.05.19PolyVir22/19 08.07.19 08.10.19 14.10.19 26.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATmaterial

one analytefee

150,00 €additional analyte


4 samples, each 200 µl virus-DNA on NaCl-Matrix➤ Analytes

Analyte 1: AdenovirenAnalyte 2: EnterovirenAnalyte 3: EBV

Analyte 4: HSV1/2Analyte 5: HPVAnalyte 6: Influenza A/B

Analyte 7: RSVAnalyte 8: VZV


ToxoGen Toxoplasma Gondii Genom


Sampledispatch date


ToxoGen1/19 11.03.19 24.04.19 29.04.19 11.05.19ToxoGen2/19 19.08.19 23.10.19 28.10.19 09.11.19




lyophilyzed DNA, 4 samples➤ Analytes

Toxoplasma Gondii Genom



B3

TubDiag Tuberculosis diagnostic


Sampledispatch date


TubDiag1/19Set 1 + 4 23.11.18 23.01.19 28.01.19 01.02.19

TubDiag1/19Set 2 23.11.18 23.01.19 28.01.19 22.03.19

TubDiag1/19Set 3 + 5 23.11.18 23.01.19 28.01.19 01.03.19

TubDiag2/19Set 1 + 4 19.07.19 18.09.19 23.09.19 27.09.19

TubDiag2/19Set 2 19.07.19 18.09.19 23.09.19 22.11.19

TubDiag2/19Set 3 + 5 19.07.19 18.09.19 23.09.19 05.11.19

This survey is organized in co-operation with Instand e. V..

€ Fee for each survey, net prices plus VAT, plus special freightset 1set 2set 3set 4set 5

45,00 €45,00 €38,00 €61,00 €36,00 €

➤ Investigation targetSet 1: Microscopy detection of acid-fast bacilli (Instand program 421).Set 2: Detection of mycobacteria by culture and differentiation between TB and NTM (Instand program 422).Set 3: Identification of mycobacteria (Instand program 423).Set 4: Detection of tubercle-bacilli by NAT (Instand progam 424).Set 5: Drug susceptibility (Instand program 425).

➤ Sample materialSet 1: 6 microscopy slidesSet 2: 5 sputum specimensSet 3: 5 suspensions of mycobacterial strainsSet 4: 5 sputum specimensSet 5: 5 suspensions of M. tuberculosis complex strains

➤ InformationFor deliveries additional freight charges will be invoiced.The registration form for this survey you will find on page 75/76.

VREscre VRE Screening


Sampledispatch date


VREscre1/19 11.02.19 13.03.19 18.03.19 30.03.19VREscre2/19 05.08.19 04.09.19 09.09.19 21.09.19




4 samples, gel smear tubes➤ Analytes

Cultural proof of VREMolecular diagnostic proof of Van A / Van B



Ejaculate investigation

EJ Semen analysis


Sampledispatch date


EJ1/19 04.02.19 11.03.19 12.03.19 11.04.19EJ2/19 09.09.19 07.10.19 08.10.19 07.11.19


➤ Sample materialWashed and fixed sperm preparation and CD-ROM

➤ AnalyteEstimation of sperm concentration and the assessment of morphgologically normal forms. Additionally the analysis of sperm motility is possible.

➤ InformationThe surveys are performed in a cooperation with the German society of andrology and their quality control organization QuaDeGa. This dispatch of the samples and the evaluation is done by QuaDeGa.The registration form for this survey you will find on page 75/76.


B4

Molecular- and cytogenetic investigations

ctDNA circulating tumor DNA


Sampledispatch date


ctDNA1/19 28.01.19 26.03.19 01.04.19 27.04.19ctDNA2/19 29.07.19 24.09.19 30.09.19 26.10.19

€ Fee for each survey inclusive normal shipping costs, net prices plus VATmaterial fee additional setone set

For multiple orders of your chosen set collection you can also use the application form 7

120,00 € 120,00 €

➤ Sample materialEDTA-plasma, 3 samples each 2 ml

➤ AnalyteSet A:

Set B:

Set C:

KRAS C12, C13(rs121913530, rs121913529, rs121913535, rs112445441, rs121913238, rs121913240, rs17851045)

BRAF V600E (rs113488022)

EGFR T790M (rs121434569)

➤ InformationThis survey is only available for european participants because of lacking sample stability with expanded shipment period.For ordering be aware of the different sets A, B and C.For certification, you have to report the concentration and the identification of the determined genotypes.The registration form for this survey you will find on page 75/76.

DI DNA isolation


Sampledispatch date


DI1/19 07.01.19 06.03.19 11.03.19 06.04.19DI2/19 03.07.19 28.08.19 02.09.19 28.09.19



➤ Sample materialfull blood, K-EDTA, 2 samples each 500 µl

➤ AnalyteDNA isolation and FV genotyping FV genotyping: FV-Leiden (ARG506GLN), FV-H1299R (HIS1299ARG),

FV-Cambridge (ARG306THR), FV-Hong-Kong (ARG306GLY), FII g20210a, MTHFR C677T, HFE (H63D, C282Y, S65C)

➤ InformationMethodological survey:determination of concentration of DNAratio 260/280method of identificationdefined genotypesResults are to be transmitted exclusively by internet www.rfb.bioMake sure that you have an online account!The registration form for this survey you will find on page 75/76.


MG1 Molecular genetics group 1


Sampledispatch date


MG11/19 28.01.19 13.03.19 18.03.19 06.04.19MG12/19 22.07.19 04.09.19 09.09.19 28.09.19


For multiple orders of your chosen set collection you can also use the application form 7.

55,00 € 30,00 €

➤ Sample materialDNA preparation, lyophilized

➤ AnalytesSet A:

Set B:

Set C:

Set D:

Set E:

Set F:

FV-Leiden, Prothrombin, MTHFR (C677T, A1298C), PAI-I 4G5G

FXIII V34L, GPIIIa, βFib (g455a), VKORC1 (G-1639A/C1173T), FXII c46t, FV-H1299R

a1 PI, Apo E, ApoB100, ACE, CETP

AldoB (149,174,334), HFE (H63D, C282Y, S65C), LCT c-13910t, NOD2 (R702W, G908R, L1007fins C)

M. Wilson (ATP7B-C3207A), FSAP (Marburg-I), ITGA2 Gplalla C807T, Col1A1 SP1,VDR (Bsml/Apal,Taql)

Faktor VII (R353Q), AT3 Cambridge Typ I/II, CYP3A5*3

➤ InformationResults are to be transmitted exclusively by internet www.rfb.bioMake sure that you have an online account!The registration form for this survey you will find on page 75/76.


B5

B5

MG2 Molecular genetics group 2


Sampledispatch date


MG21/19 28.01.19 13.03.19 18.03.19 06.04.19MG22/19 22.07.19 04.09.19 09.09.19 28.09.19


For multiple orders of your chosen set collection you can also use the application form 7.

55,00 € 30,00 €

➤ Sample materialDNA preparation, lyophilized

➤ AnalytesSet A:

Set B:

Set C:

Set D:

Set E:

Set F:

TPMT, CYP2C8 (K399R), CYP2C9*2/*3, UGT1A1 (*28), DPYD *2A (Ex 14 skipp), BCHE A/K,DPYD*13, DPYD D949V (rs67376798)

K-Ras: Codon 12/13/61, BRAF V600E, BRAF V600K, cKit D816V

HLA-B27, TNF alpha (238, 308)

CYP2D6, CYP2C19 (*2/*17), CYP2C19*3

HLA B*5701, CYP2B6*6, ABCB1 (MDR1) c.3435C>T, CCR5-del-32bp

IL28B (C/T Polymorphismus), IL6 (G174C), CYP3A4*22

➤ InformationPlease take into account the division into sets A, B, C, D, E, F when you order this survey (see application form). Please mark the sets needed on that form. Results are to be transmitted exclusively by internet www.rfb.bio Make sure that you have an online account!


➤ InformationThe following analytes are offered by our cooperation-partner European Molecular Genetics Quality Network (EMQN): (see attached flyer)8 Hereditary hemochromatosis (genotyping and interpretation) 17 Cystic fibrosis, mucoviscidosis 18 Familial breast-/ovarial- cancer (BRCA) 23 Hereditary nonpolyposis colon cancer19 21-hydroxylase deficiency (Congenital adrenal hyperplasia) 24 Huntington s disease20 Duchenne and Becker muscular dystrophy 25 Prader-Willi and Angelman syndromes21 Fragile X Syndrome 26 Spinal Muscular Atrophy22 Hereditary auditory disorder 28 Y chromosome microdeletions

SQ DNA Sequencing


Sampledispatch date


SQ1/19 07.01.19 06.03.19 11.03.19 06.04.19SQ2/19 03.07.19 28.08.19 02.09.19 28.09.19


each additional pair of samples124,00 €


DNA-preparation, lyophilized➤ Analytes

DNA sequencing and corresponding diagnostic interpretation

➤ InformationResults are to be transmitted exclusively by internet www.rfb.bioMake sure that you have an online account!The registration form for this survey you will find on page 75/76.


RfB office / survey directors / reference laboratoriesResponsible body of the Reference Institute for Bioanalytics is the

Foundation for Pathobiochemistry and Molecular Diagnostics of the DGKL Reference Institute for Bioanalytics, Bonn, Office Geilenkeuser, Dr. W.-J., Kessler, Ms. Dr. A. Survey directors Knabbe, Prof. Dr. med. C. Kohse, Prof. Dr. Dr. K. P. Neumaier, Prof. Dr. M. Reference laboratories Grote-Koska, Dr. D., Medizinische Hochschule Hannover Ritter-Sket, Ms. Dr. C., BioCampus Köln Scientific advisory board, chairman Knabbe, Prof. Dr. med. C., Herz- und Diabeteszentrum Bad Oeynhausen

Scientific advisors Adam, Ms. Dr. M. MVZ Labor Limbach München GmbH, München Ahmad-Nejad, Prof. Dr. P. HELIOS Klinikum Wuppertal, Universität Witten/Herdecke Andres, Dr. S. Nationales Referenzzentrum für Mykobakterien, Forschungszentrum Borstel Co-operation with Instand: TubDiag Aufenanger, Prof. Dr. J. Institut für Labormedizin, Klinikum Ingolstadt Baum, Prof. Dr. H. Institut für Laboratoriumsmedizin, Regionale Kliniken Holding Neckar - Schwarzwald, Ludwigsburg Bidlingmaier, Dr. M. Medizinische Klinik, Klinikum der Universität München Degel, Dr. F. Klinikum Nürnberg Nord Diekmann, Dipl.-Ing. J. Institut für Laboratoriums- und Transfusionsmedizin, UK RUB, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen Dreier, Prof. Dr. J. Institut für Laboratoriums- und Transfusionsmedizin, UK RUB, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausenm Ghebremedhin, Dr. B. HELIOS Klinikum Wuppertal, Universität Witten/Herdecke Grote-Koska, Dr. D. Medizinische Hochschule Hannover Hagel, Dr. S., M.Sc. Universitätsklinikum Jena Hallbach, Dr. J. Institut für Klinische Chemie, Städtisches Klinikum München, Schwabing Haselmann, Ms. Dr. V. Institut für Klinische Chemie, Klinikum Mannheim der Universität Heidelberg, Mannheim Hillemann, Ms. Dr. rer. nat. D. Nationales Referenzzentrum für Mykobakterien, Forschungszentrum Borstel Co-operation with Instand: TubDiag Hofmann, Prof. Dr. W. Institut für Klinische Chemie, Städtisches Klinikum München, Schwabing Kiehntopf, PD Dr. Dr. M. Universitätsklinikum Jena Knabbe, Prof. Dr. C. Institut für Laboratoriums- und Transfusionsmedizin, UK RUB, Herz- und Diabeteszentrum Nordrhein Westfalen, Bad Oeynhausen Lackner, Prof. Dr. K. J. Institut für Klinische Chemie und Laboratoriumsmedizin, Johannes Gutenberg-Universität, Mainz von Landenberg, Prof. Dr. Ph. Institut für Klinische Chemie und Laboratoriumsmedizin, Johannes Gutenberg-Universität, Mainz Lichtinghagen, Prof. Dr. R. Institut für Klinische Chemie, Medizinische Hochschule Hannover Meisel, Dr. C. Charité Vivantes, Berlin Neumaier, Prof. Dr. M. Institut für Klinische Chemie, Klinikum Mannheim der Universität Heidelberg, Mannheim Oellerich, Prof. Dr. M. Zentrum Innere Medizin, Abteilung Klinische Chemie, Georg-August-Universität, Göttingen Renz, Prof. Dr. H. Abteilung Klinische Chemie und Molekulare Diagnostik, Universitätsklinikum Gießen und Marburg, Marburg Rossmann, Ms. Dr. H. Institut für Klinische Chemie und Laboratoriumsmedizin, Johannes Gutenberg-Universität, Mainz Ruf, PD Dr. A. ZLMT-Abteilung für Transfusionsmedizin und Hämostaseologie, Klinikum Karlsruhe Schmidt, Prof. Dr. M. DRK Blutspendedienst, Frankfurt Schmidt, Dr. M. Institut für Laboratoriums- und Transfusionsmedizin, UK RUB, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen Schubert, Dr. G. Labor Berlin, Charité Vivantes GmbH Standort Klinikum im Friedrichshain, Harnsteinlabor, Berlin Siggelkow, Ms. Prof. Dr. H. MVZ Endokrinologikum Göttingen, Universitätsmedizin Göttingen Stopsack, Ms. Dr. M. Universitätsklinikum Carl Gustav Carus, Dresden Torzewski, Prof. Dr. M. Robert-Bosch-Krankenhaus, Abteilung für Labormedizin, Stuttgart Volk, Prof. Dr. H.-D. Institut für Medizinische Immunologie, Charité Campus Mitte, Berlin Vollmer, Ms. PD Dr. T. Institut für Laboratoriums- und Transfusionsmedizin, UK RUB, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen Zbinden, Prof. Dr. R. Institut für Medizinische Mikrobiologie, Zürich, Schweiz

RfB office / Survey directors / Reference laboratories / Scientific advisors 51

Conditions of participation

(as of January 1. 2019)

The Reference Institute for Bioanalytics (RfB) conducts surveys as external quality assurance for laboratory medical examinations. The services offered (surveys) include the provision of the necessary sample material for the implementation (if required), the dispatch, the evaluation of the received data as well as the preparation and transmission of corresponding certificates and/or participation certificates. The listed conditions of participation apply.

1. Participation: Everyone who carries out laboratory tests can participate in surveys for the Reference Institute of Bioanalytics (subsequently

referred to as: RfB). The following conditions for participation therefore apply. (For consumers individual stipulations and legal provisions apply).

2. Conclusion of the contractual relationship: The contractual relationship between the participant and the RfB is concluded by application and only under these participation

conditions.

3. Application Application must be made in writing or online (for registered users) and must be received in good time before the start of the

survey. Confirmations of application will only be issued upon request.

4. Content of the contractual relationship (yearly order, subscription): The participant may choose to apply for participation in individual surveys in one calendar year (Contract Type B), or in one or

more surveys to be repeated each calendar year over an unspecified period (Contract Type A, subscription).

When application is for participation in surveys to be repeated each calendar year (Contract Type A), a contract for an unspecified period will be concluded by the application. Termination of this contract requires written notice.

5. Timetable: The participant will receive a timetable before the start of each calendar year from the RfB. This timetable contains periods and

dates which are binding for the participant in relation to the surveys.

6. Withdrawal and cancellation The participant is free to withdraw from his/her participation in a survey until the respective application deadline given in the

timetable. If the participant has applied to participate in several surveys, s/he may only withdraw from his/her participation in individual surveys. If there is a subscription to surveys (Contract Type A), the participant may cancel this completely or for individual surveys.

7. Non-performance of announced surveys: The RfB retains the right not to carry out announced surveys, or to postpone them until a later date. The participants concerned

will be informed of this with an appropriate period of notice. The RfB will only refrain from the announced performance for practical reasons, in particular, in the instance of new surveys when the number of registered participants is too low.

8. Evaluation: The RfB evaluates the study results obtained by the participant in the context of a survey, provided that these are transmitted

to the RfB within the period specified in the timetable. The participant bears the risk of loss or delay for the dispatch of the data. The participant has no entitlement to the evaluation of measurement values received late by the RfB.

Certificates will be issued for measurements assessed by us. The period of validity of the certificates is regulated by the

guidelines of the German Medical Board, respectively corresponds to these guidelines and is valid from the date of issue.

9. Guarantee

9.1 The participant undertakes to test the samples after receiving them for any obvious defects, and to inform the RfB immediately if any defects are determined.

The RfB is entitled to elect its own supplementary performance, which may be by repair or by subsequent delivery.

These conditions apply both to the dispatch of samples and to the evaluation of the study results.

9.2 The RfB assumes no responsibility for injuries of any kind – in the existence of other conditions of entitlement – except in the event of intended and/or gross negligence. Furthermore, liability for compensation is excluded for injuries of any kind, no matter upon what basis a claim may be made, including liability for default on conclusion of the contract.

Impairments, which in individual cases result from postal dispatch, in particular the loss of sample shipments, will be remedied by the RfB to the best of its abilities, without the acknowledgement of any claims, by the dispatch of replacement samples. However, the contract is considered fulfilled with the initial dispatch mailing date.

10. Fees: By concluding the contractual relationship with the RfB, the participant undertakes to pay the participation fees listed respectively

by the RfB in the publication of its annual timetable.

11. Confidentiality: Individual survey data will be handled confidentially. The regulations made by the EU-GDPR for data protection will be observed,

please see details on our EU-GDPR on the next page.

12. Place of performance and court of jurisdiction: Place of performance and court of jurisdiction is Bonn.

52 Conditions of participation

Data protection declarationNo matter whether you are a participant in a ring trial, a prospective customer or are simply visiting our website: we respect and protect your private sphere. In accordance with Art. 13 of the EU General Data Protection Regulation (EU-GDPR), we hereby inform you of the means by which we collect, process and use your personal data. At the same time, we especially focus on transparent use of your data by the RfB that’s fair for you. The following provides you with an overview of what personal data we collect from you and what we do with it. We also inform you of your rights according to data protection legislation in effect and let you know who you can consult if you have any further questions. Who are we?The Reference Institute for Bioanalytics (Referenzinstitut für Bioanalytik or RfB for short) is one of two ring trial organisations which is officially commissioned by the German Medical Association to conduct ring trials for external quality control.Responsible party as per EU-GDPRReferenzinstitut für Bioanalytik, Friesdorfer Straße 153, 53175 Bonn, GermanyTelephone: +49 2 28 / 92 68 95 - 0 - Fax: +49 2 28 / 92 68 95 - 29 - E-mail: [email protected] für Pathobiochemie und Molekulare Diagnostik (Foundation for Pathobiochemistry and Molecular Diagnostics)Friesdorfer Straße 153, 53175 Bonn, GermanyTelephone: +49 2 28 / 92 68 95 - 0 - Fax: +49 2 28 / 92 68 95 - 29 - Internet: www.dgkl-rfb.de - E-mail: [email protected] directory Karlsruhe - Ref. no.: 14-0563.1Authorised representative: Dr. rer. nat. Thomas Bonk - [email protected] your data is processedWhat personal data do we collect from you?We collect your personal data if you have registered for the ring trials in written form or if you contact us through the various communication channels. We process the following specific data: Name, E-mail address, company address.If you are a participant: Participant number, password, delivery address, certificate address, billing address, telephone number and, if necessary, E-mail address, bank connection, ring trial results and all related documents. IT usage data (IP address, date and time of connection).Where does this data come from?You yourself provide us with this information when you sign up to use our services. If you are a participant: from your written registration, from a message from you via E-mail, fax or telephone, from messages over our website or, if we are missing important communication information, from internet research as well. In some cases, we also obtain your contact information from external cooperation partners. When our internet services are used, pseudonymised usage data in the form of IP addresses is collected.What do we use this data for and what are the legal bases for doing so?Fulfilment of contractual relationships (Art. 6 Para. 1b EU-GDPR): As a general rule, you are engaging in a business relationship with us (an ongoing contract) or the data processing is necessary at your request to conduct pre-contractual measures, such as: For the fulfilment of contractual relationships, such as ring trials ordered, as well as to bill for services received: To fulfil your requests and improve our offerings based on a balancing of interests (Art. 6 Para. 1f EU-GDPR): To ensure orderly operation and to optimise our offerings: We monitor the use of our services in order to ensure capacity and IT security. This is done based on IP addresses. We do not attempt to allocate the IP addresses used to your user account. Due to statutory requirements (Art. 6 Para. 1c EU-GDPR): As a special-purpose enterprise of the Foundation for Pathobiochemistry and Molecular Diagnostics, we are subject to numerous provisions of fiscal and commercial legislation. We must process and store your data in order to comply with these provisions.Based on your consent (Art. 6 Para. 1a EU-GDPR): In some cases, you have granted us your consent to process your data. You may revoke this consent at any time. This also applies to declarations of consent which you have granted us before the EU-GDPR entered into effect, i.e. before 25 May 2018.How long will we store your data for?Different periods of time apply to the storage duration of your data: Tax-related data will, as a rule, be stored for 10 years Commerce-related data will, as a rule, be stored for 6 years Usage data such as connection history (pseudonymised by IP address): 1 yearWill we transfer your data to a third party?Data collection companies have been commissioned to record your ring trial results which we receive in hard copy (fax or letter). All persons involved are obliged to comply strictly with all relevant data protection requirements. External service providersWe work with a host of external service providers who support us in providing our services. We have chosen all of our service providers carefully and contractually obligated them to comply diligently with all relevant data protection requirements. At the same time, we only transfer the minimum amount of data necessary to use these services as a matter of course.Transfer to other ring trial organisersIf you have registered with us for a ring trial which is being conducted by one of our cooperation partners (such as TH thrombophilia screening at ECAT), we will transfer all of the data relevant to the performance of the ring trial to the cooperation partner.What other rights do you have?Right to information, correction, deletion and restriction In accordance with Articles 14-17 of the EU-GDPR, we hereby inform you that you have the right to information, correction, deletion or restriction of the processing of your data.Right to revocationIf you have granted your consent to the data processing, you may revoke this at any time without affecting the legality of the processing which had already taken place based on the consent until it was revoked.Right to file a complaintYou have the right to file a complaint with a competent supervisory authority at any time.Use of cookiesCookies are small text files which are sent to your computer when our website is used We use cookies for the exclusive purpose of enabling special user functions (so-called “session cookies”). For that reason, it may be the case that you will not be able to use our website as intended without cookies. However, we do not use cookies in order to create user profiles.Most internet browsers are set to accept cookies automatically. However, you can deactivate the saving of cookies or set your browser to notify you as soon as cookies are sent. You can use your internet browser’s help function to do so.Further informationShould you have any further questions or suggestions, we will be glad to assist you at any time.

Data protection declaration 53

IndexSymbols

17-OH-progesterone 17, 2125-OH-cholecalciferol 2425-OH-D3 (25-OH-cholecalciferol), 25-(OH)2-D3 2425-OH-vitamin D total 24260 nm 18280 nm 18334 nm 18340 nm 18365 / 366 nm 18405 nm 18546 nm 18560 nm 18(IL-1 β) 25α1-antitrypsin 14α1-glycoprotein 14α1-microglobulin 17α2-macroglobulin 17α-amylase 16, 24α-HBDH 16β-2-microglobulin 23βFib (g455a) 49βFib g-455a 49γ-globulin 16γ-GT 16, 24

A

a1 PI 49AB0-system 31, 32ABCB1 (MDR1) c.3435C>T 50Accucheck 12Accutrend 12ACE 49acetaminophen 24acid phosphatase, prostate 16acid phosphatase, total 16activated partial thromboplastin time 12AD 7ADAMTS-13 22, 62ADAMTS-13 - I (activity and antigen) 22, 62ADAMTS-13 - II (inhibitor) 22ADAMTS-13 (inhibitor) 22, 62Adenoviren 45AFP 20, 23AK 7albumin 14, 15, 17, 24albumin (chem.) 16albumin (elektrophoresis) 16alcohol abuse 10alcoholic markers 10AldoB (149,174,334) 49aldosterone 13alkaline phosphatase 16, 24Allergology 70ALT 16, 24alteration of contact information 59aluminium 21AM 8amikacin 7ammonia 8, 64amphetamine 28analgesics 24antibodies 19antibody differentiation 32antibody test 31, 32antibody titer 32Anti-Borrelia burgdorferi 27, 70Anti-Candida albicans IgG 37anti-CCP-Ab 19, 20Anti-CMV IgG + total 27Anti-CMV IgM 27antidepressives 28Anti-Echinococcus IgG 37Anti-Entamoeba histolytica IgG 37Anti-HAV IgG 29

Anti-HAV IgM 29Anti-HAV total 29Anti-HBc 29Anti-HBc-IgM 29Anti-HBe 29Anti-HBs 29Anti-HCV IgG 30Anti-HCV IgG + IgM 30Anti-HIV 1/2 Ak / Ag(p24) 30anti-Müllerian hormone (AMH) 20Antinuclear antibodies 70Anti-Parvovirus B19 IgG + total 34Anti-Parvovirus B19 IgM 34Antiphospholipid Antibodies 22Antiplasmin 22, 62Anti-Plasmodium IgG total 37Anti-Rubella-Virus 34, 72Anti-Rubella-Virus IgG 34Anti-Rubella-Virus IgM 34Anti-Rubella-Virus total 34Anti-Schistosoma IgG 37Anti-Streptokokken-Desoxyribonuklease IgG 37anti-streptolysin O 19antithrombin 22, 62antithrombin III 12antithrombin III (AT III), activity 12Anti-Toxoplasma-gondii 35, 72Anti-Treponema pallidum 35, 72anti-Xa 22, 62APC resistance 22, 62ApoB100, 49Apo E 49apolipoproteins 17Application 52 application surveys 62, 64, 66, 68, 70,72, 74, 76arsenic 21Ascentia Elite 12AST 16, 24A-subgroups 31, 32AI 26AL 26allergology 26AMA 26ANA 26ANCA 26annual report 62antibodies 27, 62antinuclear antibodies 26antiphospholipide ab 26, 62application Thrombophilia screening 61AT3 Cambridge Typ I/II 49Automatic differential count 7, 64

B

BakNAT1 38, 74BakNAT1 - Genome evidence 74BakNAT2 39, 74BakNAT2 - Genome evidence 74Bakteriology Minor 40, 74BAK-TK 39, 74barbiturate 28B-cells 15BA 38Bakteriology Major 38, 74BCHE A/K 50benzodiazepine 28BG 8BI 8bilirubin 17, 33bilirubin, conjugated 9bilirubin, direct 9, 16bilirubin, indirect 9bilirubin, total 9, 16, 24bilirubin, unconjugated 9Blood gas 8, 64

blood groups 31, 32blood preparation 19blood samples 15blood slides 27BM 39, 40BNP 9Bone metabolism 18, 66bone specific alkaline phosphatase(BAP) 18Bordetella pertussis 38BorrBimm 27Borrelia burgdorferi 39BRAF V600E 48, 50Bsml/Apal/Taql 49B-Streptococci screening for cultural evidence and NAT-methods 40B-Stscre 40, 74

C

C3 complement 14C4 complement 14CA 15-3 23CA 19-9 23CA 50 23CA 72-4 23CA 125 23cadmium 21caffein 7calcitonin 23calcium 16, 24calcium, ionized 8, 16calcium, total 17Calprotectin (quantitative, qualitative) 11cancellation 52cannabinoide 28carbamazepine 7carboxyhemoglobin (COHb) 18cardiac markers 9, 64cardiac troponin I 9cardiac troponin T 9CCR5-del-32bp 50CDT 10CD transferrin 10, 47, 64CEA 23celiak disease ab 26Cell count in cerebrospinal fluid 25Cell count in CSF 68cerebrospinal fluid 15, 25, 37Cerebrospinal fluid cytology 37, 72Certificates 5, 52CETP 49changes of orders 58ChlamTra 40, 74Chlamydia pneumoniae 38Chlamydia trachomatis 38Chlamydia trachomatis AG 40, 74chloride 8, 16, 17, 21, 24cholesterol 16, 17, 24cholinesterase 16, 24chromatographic methods 36chromium 21chromogranin A 23circulating tumor DNA 48citrate 17citrullinated peptide antibodies 19CK 24CK, creatine kinase 16CK-MB mass + activity 9Clin. chem. analytes in urine, qualitative 72clinical chemical analytes 15, 16, 24, 33Clinical chemical analytes in CSF 66Clinical chemical analytes in serum 66, 68Clinical chemical analytes in urine 66CM 9CMV-DNA 44CMVimm 27CMV Serologie 27, 31, 41, 43, 70

54 Index

Indexcoagulation 12, 64cobalt 21cocain/metab. 28coeruloplasmin 14COHb 18Col1A1 SP1 49collagen binding 22, 62coloured solutions 19Conditions of participation 52conductivity 21contact 2Contract type 58contract type A 58contract type B 58contractual relationship 52copper 16, 21cortisol 13, 21court of jurisdiction 52Coxiella burnetii 38cPSA 23creatinine 16, 17, 24CRP 14CRP qualitative 14CrypCand 41, 74Cryptococcus neoformans and candida albicans antigen 41Cryptococcus neoformans andCandida albicans antigen 74CS 9CSF 15, 25, 34CSF, lyophilized 15, 34ctDNA 48CTx (CrossLaps) and P1NP 18Cultivation and identification of fungi 43, 74Cultural proof of VRE 46Culture proof of MRGN 42Cw antigen 31, 32cyanocobalamin 24cyclosporine 9CYFRA 23CYP2B6*6 50CYP2C8 (K399R) 50Cyp2C9 *2/*3 49CYP2C9*2/*3 50CYP2C19 (*2/*17) 50CYP2D6 50CYP3A4*22 50CYP3A5*3 49cystatin C 14cytocines 25, 68

D

Data protection declaration 53DD 10D-dimer 10, 64D-Dimer (FEU) 10D-Dimer, quantiativ 10defibrinated plasma 29defined genotypes 48dehydrogenase 16Detection of mycobacteria by culture anddifferentiation between TB and NTM(Instand program 422) 46Detection of tubercle-bacilli by NAT(Instand progam 424). 46Detection with culture methods 39Detection with rapid methods 39DF 27DHEA-S 13DI 48diagnoses 15differential blood count 27differentiation 7digitoxin 7digoxin 7direct Coombs‘ test 31, 32DNA 48DNA preparation 49, 50

DNA isolation 48, 76DNA sequencing 50, 76DNA sequencing 50DPYD *2A (Ex 14 skipp) 50DPYD*13 50DPYD D949V (rs67376798) 50drug group 28drug screening in urine 28, 70Drug susceptibility(Instand program 425) 46dry chemistry 12, 24, 68DS 28ds-DNA-ab 26DT 10, 47

E

EBV 45EBV-EA (early antigen) 28EBV-EBNA 28EBVimm 28, 70EBV-VCA 28ECAT 23EG 10EGFR T790M (rs121434569) 48EHEC/STEC 39EJ 47EJ Semen 76Elastase -1 (quantitative, qualitative) 11EMQN 50ENA 26Enteroviren 45Epstein-Barr-Virus serology 28, 70erythrocyte count 13, 25erythrocyte suspension 32estradiol-17β 13estriol 20ET 11, 41ethanol 11, 64ethosuximide 7Ethylglucuronide 10, 64everolimus 9

F

factor II 12factor IX 12Factor IX Inhibitor 22factor V 12factor VII 12factor VIII 12Factor VIII 22, 62factor VIII Inhibitor 62factor X 12factor XI 12factor XII 12factor XIII 12Factor XIII (activity and antigen) 22Faeces diagnostics 11, 64faktor VIII Inhibitor 22Faktor VIII Inhibitor 22Faktor VII (R353Q) 49FD 11fees 58Fees and invoice 58ferritin 13, 14fibrinogen 12Fibrinolyse Parameter I 62Fibrinolyse Parameter II 62Fibrinolysis 22flow cytometry 15folic acid 14, 24for IgE total 26for specific IgE antibodies 26Francisella tularensis 38free b-hCG 20free estriol 20FSAP 49FSAP (Marburg-I) 49

FSH 14full blood count 13FV-Genotypisierung 48FV H1299R 49FV-Leiden 49FV genotyping 48FXII c46t 49FXIII 49, 50FXIII V34L 49, 50

G

gas equilibrated solution 8GBM 26Genome evidence group 1 38, 44, 76Genome evidence group 2 39, 45, 76gentamycin 7GH 11GL 12GLDH 16glucose 8, 12, 15, 16, 17, 24, 33Glucose 64glucose measuring instrument 12glycated hemoglobin 11, 64GP 2GPIIIa 49GR 12Gram-staining 41, 74Guarantee 52

H

HA 7, 13haptoglobin 14HAVimm 29HAVimm HAV Serology 70HAV Serologie 29Hb A1c 12HBe 29HbO2 18HBsAg 29HBV-DNA 44HBVimm1 29HBVimm1 Serology Minor 29, 70HBVimm2 29HBVimm2 HBV Serology Major 29, 70HBV Serologie 29hCG 20, 23HCVimm 30, 70HCV-RNA 44HCV serology 30HDL 17Helicobacter pylori 39hematocrit 13hematology 7, 13, 27Hematology - Differential blood count 70Hematology - Full blood count 66HemoCue 12hemoglobin 13, 17, 33hemoglobin derivates 18Hemoglobin derivates 66Hemoglobin / haptoglobin complex(quantitative, qualitative) 11Hemoglobin iFOBT assay(quantitative, qualitative) 11hemoglobin (total) 18Hepatitis E virus 41Herpes viruses serology 30, 70HerpVimm 30HEV PCR 41, 74HEV PCR Hepatitis E virus 74HFE 49HFE (H63D, C282Y, S65C) 49hGH 14HIT 22, 62HIT - Immunological assays 22HIV1-RNA 44HIVimm HIV Serology 30, 70HLA-B27 15, 50

Index 55

IndexHLA B*5701 50HM 13homocysteine 17Hormones 13, 14Hormones - Group 1 66Hormones - Group 2 66HP 14HPV 45HS 31HSV 30HSV1/2 45HTLV 31human epidermal growth factor receptor 2 23Human T-lymphotropic virus 31

I

IA 31Identification of bacteria 39Identification of fungi 43, 74Identification of mycobacteria(Instand program 423) 46IG 14IgA 14, 15IgA-RF 19IgE 14, 26IgE-antibodies 27IgE total 26IGF-1 14IGFBP-3 14IgG 14, 15, 17IgG-RF 19IgM 14, 15IgM-RF 19IH 32IL-6 25IL6 (G174C) 50IL-6-POCT 25IL-8 25IL-10 25IL28B (C/T Polymorphismus) 50IM 32Immunohematology 32Immunohematology automated 31, 70immunohematology Major 32, 70Immunohematology Minor 70immunophenotyping 15, 66immunosuppressiva 9Immunosuppressives 64imprint 2indices 15Infl-RSV 42, 74Influenca and RSV antigen evidence 42Influenza A/B 45Information for application 58INR 12insulin 14Interleukin-1 β 25Interleukin-6 25Interleukin-8 25Interleukin-10 25internet 5, 48, 49, 50, 62invoice 58iron 16, 21, 24IR-spectra 31IRT 17IS 15isoenzyme 16ITGA2 49ITGA2 Gplalla C807T 49

K

K-EDTA 48Kell antigen 31, 32ketone 17, 33KL 15

K-Ras: Codon 12/13/61 50KRAS Codon 12/13/61 48KS 16KU 16, 33KUST 33

L

L1007fins 49lactate 8, 15, 16, 24LBP 25LCT 49LCT c-13910t 49LDH 16, 24LDL 17lead 21Legionella pneumophila 38leucocyte count 13, 15, 25leukocytes 17, 33LH 14Linezolid 7lipase 16, 24lipopolysaccharide-binding-protein 25lipoprotein(a) 17lipoproteins 17, 66Listeria monocytogenes 39lithium 7, 16, 24LKM-1 26long-time evaluation 62Low-Molecular Weight heparinMonitoring 22Low-Molecular Weight heparin Monitoring (anti-Xa) 22Low-Molecular Weight Heparin Monitoring (anti-Xa) 62LP 17LSD 28Lupus Anticoagulant 22, 62lymphocyte count 15

M

magnesium 16, 17, 24MaMuimm 33, 72MCH 13MCHC 13MCV 13mercury 21Meropenem 7methadon/metab. 28methaqualon/metab. 28metHb 18methemoglobin (metHb) 18methotrexate 7MG1 49MG2 50microalbumin 17Microscopy detection of acid-fastbacilli (Instand program 421) 46molecular biology 49, 50Molecular diagnostic proof of Carbapenemases 42Molecular diagnostic proof of Van A / Van B 46Molecular genetics 49Molecular genetics group 1 76Molecular genetics group 2 76Morbilli and mumps serology 33, 72morbilli IgG + IgM 33MRGNscre 42MRGN Screening 42, 74MRSA 38, 42MRSA Screening 42, 74MRSA Screening for cultural evidence and NAT-methods 42MRSAsre 42MTHFR (C677T, A1298C) 49multimers 22

MultiVir NAT 76mumps IgG + IgM 33M. Wilson (ATP7B-C3207A) 49method of identification 48methodological survey 48multimers 62Mycoplasma pneumoniae 38MykCult 43, 74MykIdent 43, 74myoglobine 9

N

NBS 17Neisseria gonorrhoeae 39neonatal bilirubin 8, 64neonatalogy 9net prices 2Net prices plus VAT 58Newborn screening 17nickel 21nitrite 17, 33NK-cells 15NOD2 49NOD2 (R702W, G908R 49NoroPCR 43Norovirus PCR 43, 74NSE 23NT-proBNP 9

O

OB 34OH 18oligoclonal bands 34Oligoclonal bands in CSF 72Onconeural ab 26online data entry 5online ordering 5online user 6online users 5opiates/opioide 28order surveys 58OS 18osmolality 16, 17osteocalcin 18oxalate 17oxyhemoglobin (HbO2) 18

P

p24 30PAI-1 22, 62PAI-I 4G5G 49pancreatic amylase 16, 24PAP 17, 23PAPP-A 20Pappenheim 27paracetamol 24ParasitB 44, 74Parasites in blood 44, 74Parasites in stool 44, 74ParasitS 44, 74parathyroid hormone 14Parvovirus B19 Serologie 34, 72pCO2 8PCT 25PCT-POCT 25pH 8, 17, 33PH 2, 18pharmaceutical drugs 36phencyclidine 28phenobarbital 7phenytoin 7phosphorus 24phosphorus, inorganic 16, 17photometer control 18, 66piperacillin 7

56 Index

Plasminogen 22, 62platelet count 13pO2 8POCT 12POCT/dry chem. 64PolyVir1 44, 76PolyVir2 45, 76potassium 8, 16, 17, 24prealbumin 14pregnancy 33pregnancy diagnostic 20, 68primidone 7Proficiency panel to detect bacteriain platelet concentrates 39progesterone 13prolactin 14propoxyphene 28prostate 16protein 17, 33Protein C 22Protein C Pathway Test 22protein S activity 22, 62protein S antigen 22, 62protein, total 16, 17, 24Protein C 62Prothrombin 49prothrombin time 12PSA 23PSA free 23pvB19imm 34pvB19imm Parvovirus B19 Serology 72pyridoxal-5-phosphate 24

Q

QBC systems 13QuaDeGa 47quotients 15

R

ratio 260/280 48RE 19red cells 25reference laboratories 51Reflotron 24registration 6renin 14renin-activity 14resistance 40resistance testing 38reticulocyte count 19retikulocytes 19, 66retinol 24RF 19RfB office 51, 52rhesus-factor 31, 32rhesus-system 31, 32rhesus-system (rhesus-formula) 32rheumatoid factors 19, 66RoetLimm 34RSV 45

S

S-100 23SA 20salicylic acid 24Saliva diagnostic 21, 68Salmonella enterica 39SCC 23scientific advisors 51screening 17SD 20selenium 21serum proteins 14, 66SHBG 14sIL-2R 25

sirolimus 9SMA 26sodium 8, 16, 17, 24sol. transferrin receptor 14soluble IL-2 receptor 25SP 21, 35specific gravity 17, 33specific IgE antibodies 26SQ 50statistics 5steroid hormones 13subscription 52, 58subscription fee 22survey directors 51SV 21SW 21Sweat analysis 21, 68SX 35Systematic toxicologic analysis 35, 72

T

T3, free 13T3, total 13T4, free 13T4, total 13tacrolimus 9TBG 13T-cells 15testosterone 13test strip and pregnancy test, qualitative 33test strips 9TG Ab 20TH 22T-helper cells 15theophylline 7therapeutic drug monitoring 7, 64Thrombin Generation Test 22, 62thrombin time 12Thrombophilia module 22Thrombophilia module I 22, 62Thrombophilia module II 22, 62Thrombophilia screening 22, 68thyreoglobulin 23thyroid antibodies 20, 66thyroid hormones 13thyroid peroxidase 20thyrotropin-receptor 20TM 23TMX 23TNF alpha (238, 308) 50TNFα 25tobramycin 7tocopherol 24topics 2total protein 15toxic agents 36toxicologic analyses 36, 72ToxoGen 45, 76ToxoGimm 35Toxoplasma Gondii Genom 45t-PA 22, 62TPA 23TPMT 50TPO Ab 20TPS 23TR 24TR Ab 20trace elements 21Trace elements in urine 68transferrin 14TrepPimm 35triglycerides 16, 17, 24TSH 13, 17TSH-R Ab 20T-suppressor cells 15Thrombophilia screening 61

TubDiag 46, 76Tuberculosis diagnostic 46tumor markers 23, 66Tumor markers group 1 23, 68Tumor markers group 2 23, 68tumor necrosis factor-alpha 25TX 36

U

UGT1a1 49UGT1A1 (*28) 50Unfractionated Heparin Monitoring 22, 62Unfractionated Heparin Monitoring(anti-Xa) 22, 62urea 16, 17, 24uric acid 16, 17, 24urinary calculus 31, 70urine 16, 21, 33, 35Urine sediment 36, 72urobilinogen 17, 33US 36

V

valproic acid 7vancomycin 7VariAimm 37VariAimm various analytes 72Various immunological analytes 37VDR 49VDR (Bsml/Apal,Taql) 49visual microscopy 19vitamin A 24vitamin B6 24vitamin B12 14, 24vitamin D 24vitamin E 24Vitamins and analgesics 24, 68Vitros 24VKORC1 49VKORC1 (G-1639A/C1173T) 49Von Willebrand Factor 62Von Willebrand Factor module 22VREscre 46VREscreening 46, 76VT 24, 36VZV 30, 45

W

watery coloured solutions 18web-based assessment 37website 5wet chemistry 16white cells 25Withdrawal 52

Y

yearly order 52, 58youdenplots 5

Z

zinc 21ZL 25, 37ZY 25ZZ 37

Index 57

Index

58 Ordering / fees / invoice

How to order surveys / fees / invoice /notes

➤ Contract type

➤ Contract type A - subscription You will receive all surveys which you marked on the order sheet. If you choose contract type A, then your individual order will automatically be renewed annually as long as

you do not cancel subscripton.

➤ Contract type B - yearly order You will receive all surveys which you marked on the order sheet. If you choose contract type B you will get the ordered surveys and nothing else. To receive further surveys for the following year: a new order will be necessary.

➤ Information for applicationIt is possible to choose either contract type A (permanent subscription) or contract type B (yearly order).The application sheets are attached in this brochure. Please mark the survey desired in the appropriate spaces and submit promptly.Participants from Europe with the exception of Germany are requested to specify their VAT (value added tax) number.

➤ Changes of ordersFor both types of contracts, any changes of orders are possible up to the application deadline of the corresponding survey.

Together with this time table for the next year you will receive an overview of the surveys you already have ordered. This overview should also be used for an order confirmation or changes in your orders.

➤ Fees and invoiceNet prices plus VAT. Costs for shipment with normal letter post are included. If the shipping conditions of the Deutsche Post should change for letters, a corresponding price adjustment is possible.The fees for each survey are given on the following pages.

Please fill out the application forms and send them to the preprinted address.

Invoicing takes place after the interlaboratory tests have been carried out. Payments may only be made by bank transfer or direct debit.

➤ Notes:Some parts of the survey (packing / data transfer) can from time to time be subcontracted. When subcontracting occurs, it is placed with a competent subcontractor and the proficiency testing provider is responsible for this work.

Parts of survey evaluations may be used for publications making note of the origin.

Alteration

Delivery address

Institute:

Name:

Street:

Post code / City:

Country:

Telephone:

Telefax:

E-mail:

Order confirmation no:

VAT:

Contact person:

Registration as online user (requires e-mail address)

Invoice Address if different from delivery address

Institute:

Name:

Street:

Post code / City:

Telephone:

Telefax:

Date Signature

participant no

Alteration of contact information

Your comment

✂


Telefax +49 228 926895-29Internet: www.rfb.bio



Alteration 59

For informations about our data policy please refer to our data protection declaration on page 53.

60

Application form for Thrombophilia screening 2019

Dear participant

if you are already registered as participant, please enter your participant number. This will be sufficient unless your address has changed.

Delivery address

Institute:

Name:

Street:

Post code / City:

Country:

Telephone:

Telefax:

E-mail:


VAT:

Contact person:


Invoice address if different from delivery address

Institute:

Name:

Street:

Post code / City:

Telephone:

Telefax:

participant no

new client

In accordance with he participation conditions for the survey Thrombophilia screening, I hereby declare my participation in the ordered survey outlined in the current survey plan (see side back). For informations about our data policy please refer to our data protection declaration on page 53.

Thrombophilia screening 2019please cross on the back.




Your comment

Ordering the survey Thrombophilia screening 61

✂

Date Signature

The participation fees are specified in the current annual survey plan.


We can not accept cancellations during the annual programme.

Annual subscription fee1 result submission via Internet / report internet 112,50 €

2 result submission via Internet / report internet + post 200,00 €

Analytes four times yearly: TH1/19, TH2/19, TH3/19, TH4/191 Thrombophilia module I

Includes an annual report on the long-time evaluation of test results Antithrombin (activity and antigen) Protein C (activity [chromogenic and clotting] and antigen) Protein S activity Protein S antigen (free and total)

345,00 €

2 Thrombophilia module II (APC resistance) 140,00 €

3 Lupus Anticoagulant / Antiphospholipide Antibodies 157,50 €

4 Von Willebrand Factor Module (antigen, activity, collagen binding, multimers)

135,00 €

5 ADAMTS-13 - I (acitivity and antigen) 180,00 €

6 Factor XIII (acitivity and antigen) 127,50 €

7 Fibrinolysis parameters I (Plasminogen, Antiplasmin) 125,50 €

8 Fibrinolysis parameters II (t-PA, PAI-1) 125,50 €

9 Unfractionated Heparin Monitoring (anti-Xa) 112,50 €

A Low-Molecular Weight Heparin Monitoring (anti-Xa) 112,50 €

Analytes two times yearly:B Factor VIII Inhibitor (TH2/19 + TH4/19) 165,00 €

C Thrombin Generation Test (TH2/19 + TH4/19) 137,50 €

D ADAMTS-13 - II (inhibitor) (TH2/19 + TH4/19) 115,00 €

E Factor IX Inhibitor (TH1/19 + TH3/19) 165,00 €

Analytes one time yearly:F HIT - I Immunological assays (TH3/19) 95,00 €

Application form forThrombophilia screening 2019

participant no

new client

62 Ordering the survey Thrombophilia screening

Application form for surveys 2019

Dear participant,

If you are already registered as participant, please enter your participant number. This will be sufficient unless your address has changed.

Delivery address

Institute:

Name:

Street:

Post code / City:

Country:

Telephone:

Telefax:

E-Mail:


VAT:

Contact person:



Institute:

Name:

Street:

Post code / City:

Telephone:

Telefax:

Date Signature

participant no

new client

Application form 1

Your comment

Application form 2019 63

✂

In accordance with the participation conditions I hereby declare my participation in the ordered surveys (Parti-cipation conditions see page 52 contract type see page 58). For informations about our data policy please refer to our data protection declaration on page 53.





participant no

new client Quantitative determinations

Automatic differential count p. 7

subscription yearly order AD1 additional samplesAD2 additional samplesAD3 additional samplesAD4 additional samplesTherapeutic drug monitoring p. 7

subscription yearly order

AK1set 1 set 2 additional setsset 3




Ammonia p. 8

subscription yearly order AM1 additional samplesAM2 additional samplesAM3 additional samplesAM4 additional samplesBlood gas p. 8

subscription yearly order BG1 additional samplesBG2 additional samplesBG3 additional samplesBG4 additional samplesNeonatal bilirubin p. 8

subscription yearly order BI1 additional samplesBI2 additional samplesBI3 additional samplesBI4 additional samplesCardiac markers p. 9


CM1 set 1 set 2

additional sets

CM2 set 1 set 2

additional sets

CM3 set 1 set 2

additional sets

CM4 set 1 set 2

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Immunosuppressives p. 9


CS1 set 1 set 2

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CS2 set 1 set 2

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D-Dimer p. 10

subscription yearly order DD1 additional samplesDD2 additional samplesDD3 additional samplesDD4 additional samplesCD Transferrin p. 10

subscription yearly order DT1 additional samplesDT2 additional samplesEthylglucuronide p. 10

subscription yearly order EG1 additional samplesEG2 additional samplesEthanol p. 11

subscription yearly order ET1 additional samplesET2 additional samplesET3 additional samplesET4 additional samplesFaeces diagnostics p. 11

subscription yearly order FD1 additional samplesFD2 additional samplesGlycated hemoglobin p. 11

subscription yearly order GH1 additional samplesGH2 additional samplesGH3 additional samplesGH4 additional samplesGlucose („wet“, „POCT/dry chem.“) p. 12

subscription yearly order GL1 additional samplesGL2 additional samplesGL3 additional samplesGL4 additional samplesCoagulation p. 12

subscription yearly order GR1 additional samplesGR2 additional samplesGR3 additional samplesGR4 additional samples

Application form 1

64 Application form 2019


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Lipoproteins p. 17subscription yearly order

LP1 additional samplesLP2 additional samplesLP3 additional samplesLP4 additional samplesNewborn Screening p. 17

subscription yearly order NBS1 additional samplesNBS2 additional samplesNBS3 additional samplesNBS4 additional samplesHemoglobin derivates p. 18

subscription yearly order OH1 additional samplesOH2 additional samplesOH3 additional samplesOH4 additional samplesBone metabolism p. 18

subscription yearly order OS1 additional samplesOS2 additional samplesPhotometer control p. 18

subscription yearly order PH1 additional samplesPH2 additional samplesReticulocytes p. 19

subscription yearly order RE1 additional samplesRE2 additional samplesRE3 additional samplesRE4 additional samplesRheumatoid factors p. 19


RF1 set 1 set 2

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RF2 set 1 set 2

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RF3 set 1 set 2

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RF4 set 1 set 2

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Thyroid antibodies p. 20subscription yearly order

SA1 additional samplesSA2 additional samples

Hematology - Full blood count p. 13

subscription yearly order HA1 additional samplesHA2 additional samplesHA3 additional samplesHA4 additional samples

Hormones - Group 1 p. 13

subscription yearly order HM1 additional samplesHM2 additional samplesHM3 additional samplesHM4 additional samplesHormones - Group 2 p. 14

subscription yearly order HP1 additional samplesHP2 additional samplesHP3 additional samplesHP4 additional samplesSerum proteins p. 14

subscription yearly order IG1 additional samplesIG2 additional samplesIG3 additional samplesIG4 additional samplesImmunophenotyping p. 15

subscription yearly order IS1 additional samplesIS2 additional samplesClinical chemical analytes in CSF p. 15

subscription yearly order KL1 additional samplesKL2 additional samplesKL3 additional samplesKL4 additional samplesClinical chemical analytes in serum p. 16

subscription yearly order KS1 additional samplesKS2 additional samplesKS3 additional samplesKS4 additional samplesKS5 additional samplesKS6 additional samplesKS7 additional samplesKS8 additional samplesClinical chemical analytes in urine p. 16

subscription yearly order KU1 additional samplesKU2 additional samplesKU3 additional samplesKU4 additional samples

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Vitamins and analgesics p. 24subscription yearly order

VT1 additional samplesVT2 additional samplesCell count in CSF p. 25

subscription yearly order ZL1 additional samplesZL2 additional samplesCytokines p. 25

subscription yearly order ZY1 additional samplesZY2 additional samplesZY3 additional samplesZY4 additional samples

Pregnancy diagnostic p. 20subscription yearly order

SD1 set 1 set 2

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SD2 set 1 set 2

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SD3 set 1 set 2

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SD4 set 1 set 2

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Trace elements in urine p. 21

subscription yearly order SP1 additional samplesSP2 additional samplesSaliva diagnostic p. 21

subscription yearly order SV1 additional samplesSV2 additional samplesSweat analysis p. 21

subscription yearly order SW1 additional samplesSW2 additional samplesThrombophilia screening p. 22 extra order on page 61Tumor markers group 1 p. 23

subscription yearly order TM1 additional samplesTM2 additional samplesTM3 additional samplesTM4 additional samplesTumor markers group 2 p. 23

subscription yearly order TMX1 additional samplesTMX2 additional samplesTMX3 additional samplesTMX4 additional samplesClinical chemical analytes in serum „dry chemistry“

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Qualitative determinations

Antinuclear antibodies p. 26subscription yearly order

AI1 set 1 set 2

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AI2 set 1 set 2

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Allergology p. 26subscription yearly order

AL1 set 1 set 2

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AL2 set 1 set 2

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AL3 set 1 set 2

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AL4 set 1 set 2

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Anti-Borrelia burgdorferi p. 27subscription yearly order

BorrBimm 1 1 set additional sets

BorrBimm 2 1 set additional setsCMVimm CMV Serology p. 27


CMVimm 1 1 set additional sets

CMVimm 2 1 set additional setsHematology - Differential blood count p. 27

subscription yearly order DF1 additional samplesDF2 additional samplesDF3 additional samplesDF4 additional samplesDrug screening in urine p. 28

subscription yearly order DS1 additional samplesDS2 additional samplesDS3 additional samplesDS4 additional samplesEBVimm Epstein-Barr-Virus serology p. 28


EBVimm 1 1 set additional sets

EBVimm 2 1 set additional setsHAVimm HAV Serology p. 29


HAVimm 1 1 set additional sets

HAVimm 2 1 set additional setsHBVimm1 Serology Minor p. 29


HBVimm1 1 1 set additional sets


HBVimm2 HBV Serology Major p. 29



HBVimm2 2 1 set additional setsHCVimm HCV Serology p. 30


HCVimm 1 1 set additional sets

HCVimm 2 1 set additional sets

HerpVimm Herpes viruses serology p. 30 subscription yearly order HerpVimm1 set 1 set 2

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HerpVimm2 set 1 set 2

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HIVimm HIV Serology p. 30 subscription yearly order

HIVimm 1 1 set additional sets

HIVimm 2 1 set additional setsUrinary calculus p. 31

subscription yearly order HS1 additional samplesHS2 additional samplesHTLVimm HumanT-lymphotropic virus p. 31 subscription yearly order

HTLVimm 1 1 set additional sets

HTLVimm 2 1 set additional setsImmunohematology automated p. 31

subscription yearly order IA1 additional samplesIA2 additional samplesIA3 additional samplesIA4 additional samplesImmunohematology Major p. 32

subscription yearly order IH1 additional samplesIH2 additional samplesIH3 additional samplesIH4 additional samplesImmunohematology Minor p. 32

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Clin. chem. analytes in urine, qualitative p. 33

subscription yearly order KUST1 additional samplesKUST2 additional samplesKUST3 additional samplesKUST4 additional samplesMaMuImm Morbilli and mumps serology p. 33

subscription yearly order MaMuImm1 set 1 set 2

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MaMuImm2 set 1 set 2

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Oligoclonal bands in CSF p. 34 subscription yearly order OB1 additional samplesOB2 additional samples

pvB19imm Parvovirus B19 Serology p. 34


pvB19imm 1 1 set additional sets

pvB19imm 2 1 set additional setsAnti-Rubella-Virus p. 34

subcription yearly order RoetLimm 1 1 set additional setsRoetLimm 2 1 set additional setsSystematic toxicologic analysis p. 35

subcription yearly order SX1 additional samplesSX2 additional samplesAnti-Toxoplasma gondii p. 35 subcription yearly order ToxoGimm 1 1 set additional setsToxoGimm 2 1 set additional setsAnti-Treponema pallidum p. 35 subcription yearly order TrepPimm 1 1 set additional setsTrepPimm 2 1 set additional setsToxicologic analyses p. 36

subcription yearly order TX1 additional samplesTX2 additional samplesUrine sediment p. 36

subcription yearly order US1 US2

VariAimm various immunologicalanalytes p. 37

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set 1 set 2 Please placeVariAimm 1 set 3 here set 4 the additional order set 5 of your set collection set 6

set 1 set 2 Please placeVariAimm 2 set 3 here set 4 the additional order set 5 of your set collection set 6

Cerebrospinal fluid cytology p. 37 subcription yearly order ZZ1 ZZ2






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Direct detection of pathogens

Bakteriology Major p. 38 subscription yearly order BA1 BA2 BakNAT1 - Genome evidence p. 38 subscription yearly order

analyte 1 analyte 5 BakNAT1 1 analyte 2 analyte 6 analyte 3 analyte 7 analyte 4 analyte 8

BakNAT1 - Genome evidence p. 38 subscription yearly order

analyte 1 analyte 5 BakNAT1 2 analyte 2 analyte 6 analyte 3 analyte 7 analyte 4 analyte 8


analyte 1 analyte 4 BakNAT2 1 analyte 2 analyte 5 analyte 3 analyte 6


analyte 1 analyte 4 BakNAT2 2 analyte 2 analyte 5 analyte 3 analyte 6

BAK-TK p. 39 subscription yearly order BAK-TK 1 Set 1 Set 2 Set 3 BAK-TK 2 Set 1 Set 2 Set 3 Bakteriology Minor p. 40

subscription yearly order BM 1 BM 2 B-Stscre B-Streptococci screening p. 40

subscription yearly order B-Stscre 1 additional samplesB-Stscre 2 additional samplesChlamTraChlamydia trachomatis AG p. 38

subscription yearly order ChlamTra 1 additional samplesChlamTra 2 additional samples

CrypCand Cryptococcus neoformans andCandida albicans antigen

p. 41

subscription yearly order CrypCand 1 additional samplesCrypCand 2 additional samples

Gram-staining p. 41 subscription yearly order GP1 additional samplesGP2 additional samplesHEVpcr Hepatitis E virus p. 41 subscription yearly order HEV 1 1 set additional setsHEV 2 1 set additional setsInfl-RSV - antigen evidence p.42 subscription yearly order

Infl-RSV 1 analyte 1 analyte 2 Infl-RSV - antigen evidence p. 42 subscription yearly order

Infl-RSV 2 analyte 1 analyte 2 MRGN Screening p. 42

subscription yearly order MRGNscre 1 additional samplesMRGNscre 1 additional samplesMRSA Screening p. 42 subscription yearly order MRSAscre 1 additional samplesMRSAscre 2 additional samplesMykCult - Cultivation and identification of fungi p. 43

subscription yearly order MykCult 1 additional samplesMykCult 2 additional samplesMykIdent Identification of fungi p. 43

subscription yearly order MykIdent 1 MykIdent 2 Norovirus PCR p. 43

subscription yearly order Noro PCR 1 additional samplesNoro PCR 2 additional samplesParasitB Parasites in blood p. 44

subscription yearly order ParasitB 1 additional samplesParasitB 2 additional samplesParasitS Parasites in stool p. 44

subscription yearly order ParasitS 1 additional samplesParasitS 2 additional samples


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Application form 7

PolyVir1Genome evidence group 1 p. 44


set 1 set 2 Please place set 3 here PolyVir1 1 set 4 the additional order set 5 of your set collection set 6 set 7 set 8

set 1 set 2 Please place set 3 here PolyVir1 2 set 4 the additional order set 5 of your set collection set 6 set 7 set 8

PolyVir2Genome evidence group 2 p. 45


analyte 1 analyte 5 PolyVir2 1 analyte 2 analyte 6 analyte 3 analyte 7 analyte 4 analyte 8

analyte 1 analyte 5 PolyVir2 2 analyte 2 analyte 6 analyte 3 analyte 7 analyte 4 analyte 8

ToxoGen Toxoplasma gondii genom p. 45

subscription yearly order ToxoGen 1 additional samplesToxoGen 2 additional samples

TubDiag Tuberculosis diagnostic p. 46


set 1 set 2 TubDiag1 set 3 set 4 set 5

set 1 set 2 TubDiag2 set 3 set 4 set 5

VREscre VRE Screening p. 46

subscription yearly order VREscre 1 additional samplesVREscre 2 additional samples

Ejakulate investigation

EJ Semen p. 47 subscription yearly order EJ1 additional samplesEJ2 additional samples

Molecular- and cytogenetic investigation

ctDNA circulating DNA p. 48 subscription yearly order

ctDNA1

Please placeset A here set B the additional orderset C of your set collection

ctDNA2

Please placeset A here set B the additional orderset C of your set collection

DNA isolation p. 48 subscription yearly order DI1 additional samplesDI2 additional samplesMolecular genetics group 1 p.49


MG1 1

set A set B Please placeset C here set D the additional orderset E of your set collectionset F

MG1 2


Molecular genetics group 2 p. 50


MG2 1


MG2 2


DNA sequencing p. 50 subscription yearly order SQ1 additional samplesSQ2 additional samples

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2019

Reference Institute for Bioanalytics Friesdorfer Straße 153, 53175 Bonn

Telephone 0228 926895-0 - Telefax 0228 926895-29 Internet: www.rfb.bio - E-Mail: [email protected]

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