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TAU-CHEM Ltd TAU-CHEM Ltd . . 1994-200 1994-200 8 8 14 YEARS OF CUSTOM SYNTHESIS & SPECIALITY CHEMICAL MANUFACTURE
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TAU-CHEM LtdTAU-CHEM Ltd. .
1994-2001994-20088
14 YEARS OFCUSTOM SYNTHESIS &SPECIALITY CHEMICAL
MANUFACTURE
Dear Sir ,
We would like to draw your kind attention to our company Tau-chem, Ltd. that you may recall as your Slovak business partner operating in the custom synthesis and specialty chemical manufacturing. The company celebrates its 14th anniversary these yearwhich is not only an occasion for overall evaluation of the results achieved in the previous years but also for outlining new plans and development of the company in future.
The results that have been achieved since establishment of the company are that we think can be proud of. The indicators such asthe database of more than 12 000 compounds accomplished with the complete literature research, the product catalogue containing 400 compounds accomplished with the technology documentation prove the sound functionality and abilities of the company. .Within its existence the company acquired number of business partners as well as distinguished position on the market. Thinking of future, the 5 years strategy plan developed by the company owners and managers started to be pursued in 2003 and have not stopped in performing all its key ideas also this year. The strategy ideas formulate our efforts to provide continually increasing quality of services to our customers, improvement of the working environment, expansion of the reactor capacity, introduction of modern technologies including biotechnology. Another important goal is implementation of Environmental management system leading to ISO 14001 certification.
I would like to underline that Slovakia were in May 2004 admitted to the EU presenting new opportunities for growth, investment and outsourcing. The EU15 has a relative abundance of capital and technology, while the new countries a relative abundance of skilled labor at low cost. The synergies between them are so obvious that further comment seem redundant.
On the occasion of placing the new issue of Product list on the network and Edition 2008 of Tau-chem’s Catalogue I would like acknowledge for your enquiries, orders and at last but not at least your proper look toward Tau-Chem LtdI believe that the former co-operation between your company and Tau-Chem Ltd take a continuation for the profit of both sites. The staff off Tau-chem’s , 3 PhD degree, 16 University degree, 4 High school degree, is ready to fulfill your order as well as the technological support are fully in disposition for manufacturing of molecules in accord with your exigency.
I look forward to hearing from you.
Vladimir Zvak, PhD,Director
Tau-Chem Ltd. company was established in 1994
by four University schoolfellows (1975)
Dr. Marian Ježek
Dipl. Ing. Juraj Ďuris
Dr. Jan Hrabovsky
Dr. Vladimir Žvak
1998
Dipl. Ing. Juraj Ďuris
left company
Dr. Marian Ježek †
died in car accident
ISTROCHEM was established on the end of 19th century
by Alfred Nobel group. 23rd October 1873, first written notice. Alfred Nobel: personally supervised the rise up1892: first stage was completed
1995 Location of the premises in the area of Istrochem AG.
The most important period of company were the years 70-thies, Chemical factories of Juraj Dimitrov employed about 8000 employees
80th-stagnation, 90th shut down, private company 648 employees, renter of his assets
Decision for the region of Pressburg (Bratislava) was made on the basis of following aspects:A, Location in the middle of Austro-Hungarian monarchyB, railway junction for nine directionsC, important crossroadsD, fluvial port on the river Danube
Dynamit Nobel AG.Dynamit Nobel AG.
Bratislava 1920
November 1995 start up manufacturing3 employees, 1 laboratory
• Epoxides• Furans and
benzofurans• Imidazoles • Pyridines• Thiophenes• Other heterocycles• Benzenes• Various• Chiral compounds• Aromatics
EPOXIDESEPOXIDES
Batch size: up to 2500 liter of reactants
O
nn=1,2,3
O O
O
O+ H3C
O
O OH
Na2CO3
Total: 18
O
n=3,5,7,9n
O
n=1,2,3
On
FURANS, BENZOFURANSFURANS, BENZOFURANS
Mono 2-substituted
reagentssolventstemperaturecatalyze etc.
Specific reaction conditions
O CHO + HC(OC2H5)3 O
OC2H5
OC2H5
O CN O COOH OOH
OO
FURANS, BENZOFURANSFURANS, BENZOFURANS
Mono 3-substituted
O + O
O
O
O
O
O
O O
O
O
OBr
Br O
Br2Br
O
COOH
O
CH2OH
O
CN
Batch size:200l, 15 kg of final product
FURANS, BENZOFURANSFURANS, BENZOFURANS
2,5-disubstituted
O CH2OHHNO3
Ac2O O CH2ONO2O2N
Batch size: 20 l
O
O
O
Br CHO
COOC2H5ClH2C
CHOH3C
O CHO
N2Cl
+X
O CHO
X
Batch size: 20 lX=Cl, o,m,p-NO2
FURANS, BENZOFURANSFURANS, BENZOFURANS2,3-disubstituted
OHCH2OH
CH2OH
+
O
Batch size: liter
Batch size:150 liter
CH3COCH2COOCH3 + ClCH2CHO O
COOCH3
FURANS, BENZOFURANSFURANS, BENZOFURANS
2,4,5-trisubstituted
OPOCl3/DMF
O CHO+
Batch size: 40 liter O
O
O COOH
COOH
COOH
OH
CHO
+ ClCH2COOC2H5O
COOH
Batch size: 150 liter
O
O
O
O
CHO
Total: 56
IMIDAZOLESIMIDAZOLES
O2N ClN
HN+ NO2N N
NN NH2
NN CHO
NN CN
NN COOH
NN OH
Batch size: 10 liter
Total: 16
PYRIDINESPYRIDINES
N
COOH
Batch size: starter 20 liter, target molecule 100 g
2-,3-,4-Pyridylacetic acid
N
N
ON
O
NO2
N
O
O
N
O
OH N
OH
OH
Total: 19
THIOPHENESTHIOPHENES
SO
O
O
SO
O
OH
S O
OH
S
O
+
Batch size: starter 150 liters, target molecule kgs
S SHS
Br
CHO SCOOH
Total: 18
S COOH
OTHER HETEROCYCLESOTHER HETEROCYCLES
Batch size: starter 25 liter , target molecule 1 kg
3-Isobutyl-1-methylxanthine
NH2 + KNCO NH
NH2
ONCCH2COOH HN
N
O
O NH2
N
N
O
O NH2
DMS
N
N
O
O NH2
NaNO2NO H2 N
N
O
O NH2
NH2HCOOH N
N
O
O NH
N
Total: 70
OTHER HETEROCYCLESOTHER HETEROCYCLES
NN
S NH2N
O COCl N
O
NH2
N
N
N
N
N
N
Cl
Cl
Cl
Cl
COOCH3
COOCH3
Cl
N
NO2
O
N
CHOCHO
COOCH3
S
N
HO
Pyrimidines:
5-membered:
Condensed:
BENZENESBENZENES
+ CH2O/HClCl
Batch size: 400 litre
Mesitylenes and pentamethylbenzenes
X
X
X
X
NO2
HSO3Cl
NO2
SO2Cl
KF
NO2
SO2F
H2
NH2
SO2F
Batch size: 6 liter
X=SH, OH, COOH
Total: 93
VARIOUSVARIOUS
ClCOOCH2CH3
+
H2NNH2
CH3CH2OC
O
NH NH COCH2CH3
O
CH3CH2OC
O
N N COCH2CH3
O
Bestseller: 250kg per month
Future bestseller : batch size 250 litre
Total: 80
Br
Br
Br
CHIRAL COMPOUNDSCHIRAL COMPOUNDS
Beta-amino acids
HN
COOH
O
O
NaBH4
HN
CH2OH
O
O
i CH3SO2Cl
ii KCN HN
CH2CN
O
O
NH2
COOH
CHIRAL COMPOUNDSCHIRAL COMPOUNDS
EPOXIDESEPOXIDES:
Sharpless protocol:
O
OH
OH
O
N NHH
O OCo
III
OAc
H2O
HKR:
Batch size: 50 litre
Total: 41
OH (+) DET
OOH/Ti(OiPr)4
OH
O
REDUCTIONREDUCTION
H2N CHC
CH2
OH
O
NaBH4/I2
THF
H2N CH
CH2
CH2OH
Hydrides reduction
kilo-lab scale
O
OH
HO
HOOH
arabinose
OH
HO
HOOH
CH2OH
arabitol
H2
Ra/Ni
catalytic reduction
100 atm/120oC
COOH
Na/NH3(l)
COOHH
H H
Birch reductionlab-scale
OXIDATIONOXIDATION
CH3COOOH
O
Epoxidationfull plant
NO2
OH
Na2Cr2O7
NO2
O
kilo-lab
N
OH
HNO3
N
COOH
COOH
lab-scale
HALOGENATIONHALOGENATION
S
Br2
SBr Br
Br
kilo-lab
H2N
O
OC2H5
Cl2
N
O
OC2H5Cl
Cl
lab-scale
I2I CH2CH2 I kilo-lab
DEHALOGENATIONDEHALOGENATION
Br BrHMPT
Brpilot plant
O2NBr
TEA O2N kilo-lab
O
OHBr
Br
Br
kilo--lab
ORGANOMETALLIC REACTIONSORGANOMETALLIC REACTIONS
O
Br
O
MgBr
O
COOH
Mg CO2lab-scale
S
BuLi
S LiS
S SH kilo-lab
BrMg
MgBr
O
OH
pilot plant
HAZARDOUS REACTIONSHAZARDOUS REACTIONS
NH2
F
CSCl2
NCS
F
thiophosgenation
lab-scale
NH
Cl C
Cl
Cl
O C
O
Cl
N
COCl
chloroformylation
lab- scale
Cl
Cl
Cl HSO3Cl Cl
SO2Cl
Cl
Cl
chlorosulfonation
lab-scale
EQUIPMENTEQUIPMENT
Fully equipped laboratories for research, lab-scale, kilo-scale and pilot-plant production, contracted access to full production plant
Reactors in glass (25 l - 100 l) Stills in glass100 l and 25 l Distillation vacuum unit 100 l Molecular Distillation Apparatus (20 Pa) 200 l stainless reactor 250, 500, 2000, 6000 l glass lined reactors 2 l Büchi high pressure reactorň 100 l Jahndorf high pressure reactor Rotatory evaporator Heidolph Laborota 20 Walk in fume hoods
EQUIPMENTEQUIPMENT
QUALITY CONTROLE
• GC Varian 3350• GC Varian 3400• GCMS Varian Saturn 2100T• HPLC Varian 9012/9065• HPLC Varian • Titration unit• Melting point unit
ORGANIZATION ORGANIZATION
20 employees, 15 university degree, 3 PhD
Lab.1
Lab.2
Lab.3
Director
Executive office
Advisorycouncil
Production manager
Marketing and sales
director
Quality control
manager
Trustee
DEVELOPMENT PLANDEVELOPMENT PLAN
New administration, research, kilo-lab establishment (project)
DEVELOPMENT PLANDEVELOPMENT PLANNew administration, research, kilo-lab establishment (matter of fact)
DEVELOPMENT PLANDEVELOPMENT PLAN
•Start-up new administration, research and kilo-lab establishment
•Raise cascade reactor system 2007
•Increase a reactor volume capacity 2007
•Establish a biotechnological unit 2009
•Certification 2008
•Fragrances and flavors production 2007
•
MISSIONMISSION
We would like to become a small-sized company dedicated to custom synthesis and contract manufacturing and to be known as:
-Enterprise with highly skilled staff targeted and devoted to the Enterprise with highly skilled staff targeted and devoted to the company`s missioncompany`s mission
-Environmental friendly producerEnvironmental friendly producer
-Reliable partnerReliable partner
STAFFSTAFF
To place your order, enquire or to obtain product information, Please telephone or write to:
TAU-CHEM LTDNobelova 34P.O. BOX 29
836 05 Bratislava Slovak Republic
Registered in Slovak RepublicVAT reg. Number: SK2020333856Telephone: ++421 2 44452252Fax: ++421 2 44457645 E-mail: [email protected]
Product list is available on the Internet address: http://www.tau-chem.sk
Principal contact: Mr. Martin Rybár Mr. Vladimír ŽvakMarketing and sales director CEO
