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Temperature Profiles High-Intensity Focused Ultrasound (HIFU): Fig 1: the HIFU Device Fig 2: the HIFU treatment (Haifu co, ltd) (from UT ltd) Non-invasive monitoring and control in ultrasound cancer therapy Guoliang Ye, Penny Probert Smith, Alison Noble, {ye, pjp, noble} @robots.ox.ac.uk Wolfson Medical Vision Laboratory, Department of Engineering Science, University of Oxford Fares Mayia, [email protected], Dept. of Medical Physics, Churchill Hospital, Oxford. Objectives of Research: To enhance images (US) for feedback to surgeons To control of the treatment (head position and exposure) How? Principle: Temperature change change in ultrasound velocity echo shifts in image (Fig. 3) Techniques: Monitoring the region around the lesion during therapy, processing to find apparent strain, matching profiles to temperature Challenges: image noise, small change Fig 3: the RF signals from a gelatine phantom Future work 1. Further development of spatio-temporal MRF classification. 2. Validation for off-line monitoring of tissues. 3. To relate image-derived measures to treatment success. Supported by Oxford Regional Health Authority 1. Data Acquisition: 1.1 Build a test object (gelatine phantom) 1.2 Apply a cyclic heat (temperature) (Fig. 4) 1.3 For a number of time points, acquire RF images: A-line scan (Fig. 3) shows a region being heated 1.4 Convert to B-scan images (e.g. Fig. 5) for visualisation Fig 4:Cyclic temperature on the heat source in the phantom Fig 5: B-scan image 2. Data Processing: 2.1 Resample the RF images and get the displacement (echo shifts) map (Fig. 6, 7) by the correlation of two images 2.2 Apply a median filter on the displacement map to reduce the noise caused by the decorrelation of the images (Fig. 8). 2.3 Differentiate displacement map to get an apparent strain map (Fig. 9) by fitting a straight line along the axial direction (Least Square Method) Fig 6: the displacement map Fig 7: A-line signal from fig. 6 3. Temperature Profiles Extraction 3.1 Get temperature (Fig. 10) from the strain: a model derived from the change of sound velocity is used. where is the posterior temperature, , are the prior temperature and sound velocity, : a linear coefficient related to temperature and the speed of sound, C=1540, is the strain. n denotes the position on an A-line signal. 3.2 Temperature classification (Fig. 11) on the temperature map (through an MRF model) Fig 11: temperature maps before (left) and after (right) classification Heat source n C n c n c n T n T n T n T o o o o n T n T o n c o n Fig 10 : a 3-D shaded surface plot of the temperature map from Ultrasound Images
