CAT

The energetic production of the cell

Base theory

physiology

Cellular primary metabolism

• The cells need energy to live.

• This is stored in the form of chemical

energy as ATPenergy as ATP

Vital cycles

• Vegetables:

– 6CO2 + 6H2O + energy = C6H12O6 + 6O2

• human:

– 6CO2 + 6H2O + energy = C6H12O6 + 6O2

Energetic production in the

heterotrophs

• The animals starting from compound

substances (in particular glucose) break

down them into C H Odown them into C H O

• The union of H with O (external) create

water

• All this processes create energy stored in

links with high energy

• All these reactions need substrates (among

which the oxygen) and catalysts

cells

ENERGY = Combustible + Oxidizing +

Facilitation

C6H12O6 + O2 = CO2 + H2O + Energy

eat

breath

CATALYSIS

• CATALYST:– MAKES POSSIBLE AND ACCELERATE A

CHEMICAL REACTION

• BIOLOGICAL CATALYSTS • BIOLOGICAL CATALYSTS

• ENZYMES (FERMENT INSIDE)– APOENZYME + COENZYME

• SABATIER AND SENDERENS DISCOVERERS OF C. CHEMISTRY

• BARZELIUS FOR THE VEGETABLE

Enzymes’ place to produce energy: mitochondrion

CAT

CAT

M

biochemistry

• From glucose, fatty acids, amino acids is product AcetylCoA that enter in the…

• Krebs’ or tricarboxylic acids’ or citric acid’s cycle that…

• Krebs’ or tricarboxylic acids’ or citric acid’s cycle that…

• transforms FAD in FADH2 and NAD in NADH…

• these enter in the respiratory chain with O and reload from ADP to ATP (ENERGY)

Functions of K.C.

• Generator of energy

• Precursor of R.C. (NADH)

• Decreased lactic acid• Decreased lactic acid

• Production of useful metabolites

Citric acid cycle more than is

central in the energetic

metabolism, it is also a

fundamental precursors’ source

for some biosynthesis.

Respiratory chain

Functions of R.C.

• From NADH and FADH energy generation

Flusso di H passivo (downhill), formazione

di ATP passivo

Flusso di elettroni passivo (downhill), di H

attivo

FAD

Good energetic production

• To assume:

– Combustible

– Oxidizing– Oxidizing

– Enzymes

ROS

• The production of ROS is normal at the end

of respiratory chain

• ROS are toxics• ROS are toxics

• O2 + e¯ = O2¯ ˙

Quinones

• There are substances (quinones) that,

– Following their redox potential, are stimulating

or toxics (ROS)or toxics (ROS)

CAT

M

pathology

pathology

Bad energetic production

• To assume a little or to

lose:

Increase of ROS

• quinones

– Combustible

– Oxydizing

– Enzymes

• Enzymatic blocks

Blocks

• There are substances (quinones) that,

– block the CoQ (Ubiquinone),

making unavailable the cellular respiration, making unavailable the cellular respiration,

slowing down the energetic production

ROS

• There are substances (quinones) that,

– Very reactive in oxide-reduction

– increase the R.O.S.– increase the R.O.S.

damaging metabolisms

Quinones

Benzoquinone, or quinone, is a term used to describe the 2 cyclohexadienedione’s isomers. The brute formula of the compound is C6H4O2.

Exist two isomers of benzoquionones, the 1,2-benzoquinone and the1,4-benzoquinone, both are the dehydrogenation’s (oxidation) result

respectively of 1,2-dihydroxybenzene and of 1,4-dihydroxybenzene. A solution of potassium iodide (KI) reduce a benzoquinone’s solution to

hydroquinone, that can be re-oxidized with a solution of silver nitrate.

With “quinone” is also indicated a compounds’ block that can be considered as structural analogous deriving. The quinones aren’t aromatic

compounds, they are diene dichetones.

1,2-benzoquinone

1,4-benzoquinone1,4-benzoquinone

Biochemistry

The quinones have a double biological importance.

They find themselves in the nucleus of different organic substances fundamental for the metabolism functioning, like for example the

coenzyme Q involved in the electrons’ transport to the level of mitochondria. They are also constituent nucleus of vitamin K’s various forms

(menadione, pyilloquinones, exc.).

On the other side, in the same breath the quinones are very reactive molecules. Their double links are endowed with electrophile properties and

can form covalent bonds with various chemical groups (thiols, amines, exc.). Very often this make them substances endowed with bactericide

power, antifungal, anti-inflammatory, cytotoxic and also mutagen. In the nature are present a lot of examples of compounds derived from the

benzoquinone and endowed with very powerful biological or pharmaceutical properties:

therapy

Therapy

• Push and

• Release

CAT

• 1 krebs

• 2 quinones and respiratory chain

• 3 quinones• 3 quinones

characteristics

Anatomical-functional organization of

the complexity

Everyone separate

by a membrane body

Like briefcases and

files

nucleus

cells

organ

nucleus

cells

organ

nucleus

cells

organ

Cells

CAT

• CATalyst• NAD, metabolites of the Krebs’ cycle and

respiratory chain, quinones, vitaminsrespiratory chain, quinones, vitamins

CAT (biochemical action)

• NAD

– energetic carrier

• metabolites of Krebs’ cycle

– inducing– inducing

• metabolites of respiratory chain

– inducing

• quinones

– unblocking

• vitamins

– coenzymes

CAT

NAD metabolites

vitamins quinones

Good energetic production

• To assume:

– Combustible

– Oxidizing– Oxidizing

– Enzymes

• To facilitate the enzymatic action

– Homeopathised enzyme

• To avoid the enzymatic blocks

– Homeopathised obstruents

Substrates

• The substrates’ presence of the enzymes induce

them to a better functioning

use

CAT use

• Acute or long time diseases that have run

out the cellular energetic resources

• Deep poisonings that have damaged the • Deep poisonings that have damaged the

ground system and nicked the cell

• Rejuvenation (in the RIGE and anti-aging

protocols)

• Mitochondrial detoxification (in the DRE or

DIS protocols)

use

• 20*3

Handbook

Cells

CAT

• CATalysts– Krebs cycle

– Respiratory chain, – Respiratory chain,

– quinones

• CAT 1 krebs

• CAT 2 quinones and catalysts

• CAT 3 quinones and NAD• CAT 3 quinones and NAD

CAT 1

• Substrates of Krebs cycle + Mg+ Mn +

NAD

CAT 1 action

• The enzymes’ substrates are present and in

this way are induced (speed in inverse

proportion to the substrate)proportion to the substrate)

• The pyruvic acid enters in the cycle and

don’t become lactic

• INDUCTION OF KREBS CYCLE

CAT 2

• Quinones: stimulus to the elimination of blocking quinones

• ATP , CoA, ubiquinones: enzymatic favouring

• vitamins: coenzymes• vitamins: coenzymes

– B6 Krebs

– B3 NAD

• Neutralization of energetic blocks and aiding the respiratory chain

CAT 3

• NAD

• quinones: stimulus to the elimination of blocking quinones

• GENERAL AND RESPIRATORY CHAIN INDUCTION AND ACCELERATION

• Diathesic use

CAT 2

• Lipoic acid

• anthraquinone

• ATP

• benzoquinone

• Methylene blue

• methylglyoxal

• naphthoquinone

• NAD• benzoquinone

• chinidrone

• coenzyme A

• glyoxal

• hydroquinone

• gluconic magnesia

• NAD

• trichinoyl

• ubiquinone

• B1

• B2

• B6

• C

The end