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THE INCIDENCE OF GENERAL PARALYSIS

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350 in the molar region will not be very successful, and it may even be necessary to wait until the pre-molars erupt. There is also a distinct advantage in expanding before the permanent laterals appear. Later treat- ment may well be successful, but it will have to be more elaborate and more prolonged. Although the majority of children do not resent orthodontic appliances, profound psychological difficulties may be provided by the parents. Mr. Pitts tells amusing tales of parents who interfered, more or less success- fully, with treatment which was causing their child no trouble whatever. He recommends the dentist to take the parents into his confidence, to explain to them as fully as possible the why and the wherefore of the treatment in its various stages. Dealing with the vexed question of fixed or removable applances, he holds that the wise dentist will use either according to the particular case. On the difficult problem of anchorage, he says that it is wise in every case to over-estimate the resistance of the teeth to be removed, and to under-estimate the resistance of the teeth to be used for anchorage ; it is far better to have an excessive anchorage than too little. Although it may be necessary to raise the bite deliberately as part of the treatment, this should be looked upon as an evil procedure likely to do harm in ordinary cases. Irretrievable damage has been done by capping a bite when this was not necessary, and Mr. Pitts’s advice to those who meditate this orthodontic crime is " don’t." He is a whole-hearted advocate of extraction, but with certain qualifications. He thinks that extraction should be regarded as an ancillary method of treatment, and usually combined with an appliance. A patient from whom a tooth has been extracted should always be watched carefully to be sure that the gap is properly filled in. Practical advice like this is invaluable to the dentist and of great importance to the medical man. If the family doctor does not hold sound views the dentist may not see the case until too late or may plead the necessity for treatment in vain. The general practi- tioner of both professions would profit by a study of Mr. Pitts’s paper. ____ THE HEALTH OF THE ARMY IN 1926. THE annual report of the health of the Army has just appeared and reveals a slightly higher invalid- rate, a lower number of constantly sick, and an identical death-rate with that of 1925. It was found that officers in India were less well protected by antityphoid inoculation than were the men, although there was an improvement on last year. Injury heads the list of causes of death among " other ranks," followed by pneumonia and diseases of the digestive system. There was a decrease in the number of deaths from both these natural causes. The principal cause of invaliding was middle-ear disease, which remains high and gives some cause for anxiety. Nearly a quarter of all the men invalided during 1926 suffered from ear trouble. The majority of men admitted to hospital were suffering from malaria, which was unusually severe in the Western Command in India. Influenza was very mild and only caused one death, but there were over a thousand more cases than in 1925. An interesting side-result of the coal strike was an increase in the amount of scabies, and the fact that each case lasted half a day longer than usual under treatment. This is attributed to the lack of hot water. Bermuda was the most healthy command and Malaya the worst. Venereal diseases diminished in frequency, but there is still a high incidence about the time of the Christmas furlough, when men expose themselves to infection without the preventive facilities that are available in barracks. It is hoped that a reduction in the incidence and an improvement in treatment may result from careful attention to these facts. The liability of uninoculated men to typhoid fever was seven or eight times greater than that of the inoculated, and the mortality ten times greater. We observed three years ago 1 that 1 THE LANCET, 1924, ii., 664. there was no discussion on the prevalence of tuber- culosis in the reports of either of the three services. This year we note that " the whole subject of pulmonary tuberculosis in the services is being investigated by a special committee and the relation of this disease to service conditions, its incidence,- invaliding, and attributability will be the subject of a report." We hope to deal with the figures of this report more fully in a later issue. PROTEIN TREATMENT OF DRUG-ADDICTION. , ABOUT a year ago A. Lambert and F. Tilneyl described a new treatment of drug-addiction with a preparation called narcosan, which consists of a solution of lipoids, non-specific proteins, and water- soluble vitamins. The treatment is based on an assumption that narcotics such as morphia cause toxic bodies to be formed in the body, and that these bodies neutralise the narcotic and, in so doing, are themselves neutralised. When the narcotic is withdrawn these toxic bodies cause withdrawal symptoms because they are no longer being neutralised. Lambert and Tilney therefore proposed that when a narcotic is withdrawn narcosan should be given instead, in the hope that the lipoids which it contains will neutralise the toxic bodies, and thus prevent symptoms. The authors of a recent paper 2 on drug-addiction consider that the results of narcosan treatment are not consistent with the hypothesis on which it is based, and quote evidence to show that drug-addiction is associated with hypo- function of the endocrine system, secondary possibly to disturbance of the sympathetic. According to this hypothesis, withdrawal symptoms are due to a func- tional upheaval in the endocrine system. They state that the results of treatment with various endocrine extracts and also by hypodermic injection of solutions of vegetable proteins, which are regarded as stimulants of the endocrine system, confirm this hypothesis, and they point out that one of the vegetable protein substances (alfalfa protein) which they used as an endocrine stimulant is also present in narcosan. It is suggested that the beneficial effects of the latter preparation are due not to its ability to neutralise toxic bodies formed in response to the narcotic, but rather to the stimulating effect of alfalfa protein on the endocrine system. Acting on this assumption they treated a series of drug-addicts with alfalfa protein and obtained results similar in every way to those obtained with narcosan. Withdrawal symptoms were slight and the patients remained in good physical condition. It seems probable, they say, that proteins prepared from millet, rape, and hemp seed will give equally satisfactory results, but recommend that all forms of protein treatment should be reinforced by synchronous administration of orchitic and ovarian extracts, on the grounds that sexual function is invariably affected in drug-addicts. An advantage of alfalfa protein over narcosan is that it is very much cheaper. ____ THE INCIDENCE OF GENERAL PARALYSIS IN view of the reports from all sides which indicate that mental disorder of every kind is on the increase in the United States, it is interesting to study the figures for syphilis and general paralysis recently issued by the United States Public Health Service to the Office International.3 The incidence of syphilis among the general population is, of course, uncertain, but the percentage of recruits giving a positive Wassermann reaction, out of a group of close on 12,000 in 1916 was 13, and out of 856 candidates for the Washington police 15. The consensus of opinion puts the figure at 10 per cent. for the whole population, but recent research has tended to lower it. The proportion of general paralytics to others in mental hospitals seems 1 Med. Jour. and Record, 1926, cxxiv., 764. 2 The Proteal Treatment of Drug Addiction, by M. G. Carter, T. J. Orbison, E. H. Steele, C. A. Wright, and E. H. Williams: Med. Jour. and Record, Sept. 7th, 1927, pp. 282-284. 3 Office International d’Hygiène Publique, Bulletin Mensuel, xix., 11.
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Page 1: THE INCIDENCE OF GENERAL PARALYSIS

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in the molar region will not be very successful, andit may even be necessary to wait until the pre-molarserupt. There is also a distinct advantage in expandingbefore the permanent laterals appear. Later treat-ment may well be successful, but it will have to bemore elaborate and more prolonged. Although themajority of children do not resent orthodonticappliances, profound psychological difficulties maybe provided by the parents. Mr. Pitts tells amusingtales of parents who interfered, more or less success-fully, with treatment which was causing their childno trouble whatever. He recommends the dentistto take the parents into his confidence, to explainto them as fully as possible the why and the whereforeof the treatment in its various stages. Dealing withthe vexed question of fixed or removable applances,he holds that the wise dentist will use either accordingto the particular case. On the difficult problem ofanchorage, he says that it is wise in every case toover-estimate the resistance of the teeth to be removed,and to under-estimate the resistance of the teethto be used for anchorage ; it is far better to havean excessive anchorage than too little. Although itmay be necessary to raise the bite deliberately aspart of the treatment, this should be looked uponas an evil procedure likely to do harm in ordinarycases. Irretrievable damage has been done bycapping a bite when this was not necessary, and Mr.Pitts’s advice to those who meditate this orthodonticcrime is " don’t." He is a whole-hearted advocateof extraction, but with certain qualifications. Hethinks that extraction should be regarded as an

ancillary method of treatment, and usually combinedwith an appliance. A patient from whom a tooth hasbeen extracted should always be watched carefullyto be sure that the gap is properly filled in. Practicaladvice like this is invaluable to the dentist and ofgreat importance to the medical man. If the familydoctor does not hold sound views the dentist maynot see the case until too late or may plead thenecessity for treatment in vain. The general practi-tioner of both professions would profit by a study ofMr. Pitts’s paper. ____

THE HEALTH OF THE ARMY IN 1926.

THE annual report of the health of the Army hasjust appeared and reveals a slightly higher invalid-rate, a lower number of constantly sick, and anidentical death-rate with that of 1925. It was foundthat officers in India were less well protected byantityphoid inoculation than were the men, althoughthere was an improvement on last year. Injuryheads the list of causes of death among " otherranks," followed by pneumonia and diseases of thedigestive system. There was a decrease in the numberof deaths from both these natural causes. The

principal cause of invaliding was middle-ear disease,which remains high and gives some cause for anxiety.Nearly a quarter of all the men invalided during1926 suffered from ear trouble. The majority ofmen admitted to hospital were suffering from malaria,which was unusually severe in the Western Commandin India. Influenza was very mild and only causedone death, but there were over a thousand morecases than in 1925. An interesting side-result of thecoal strike was an increase in the amount of scabies,and the fact that each case lasted half a day longerthan usual under treatment. This is attributed tothe lack of hot water. Bermuda was the most healthycommand and Malaya the worst. Venereal diseasesdiminished in frequency, but there is still a highincidence about the time of the Christmas furlough,when men expose themselves to infection withoutthe preventive facilities that are available in barracks.It is hoped that a reduction in the incidence and animprovement in treatment may result from carefulattention to these facts. The liability of uninoculatedmen to typhoid fever was seven or eight times greaterthan that of the inoculated, and the mortality tentimes greater. We observed three years ago 1 that

1 THE LANCET, 1924, ii., 664.

there was no discussion on the prevalence of tuber-culosis in the reports of either of the three services.This year we note that " the whole subject ofpulmonary tuberculosis in the services is beinginvestigated by a special committee and the relationof this disease to service conditions, its incidence,-invaliding, and attributability will be the subject ofa report." We hope to deal with the figures of thisreport more fully in a later issue.

PROTEIN TREATMENT OF DRUG-ADDICTION.

, ABOUT a year ago A. Lambert and F. Tilneyldescribed a new treatment of drug-addiction with apreparation called narcosan, which consists of a

solution of lipoids, non-specific proteins, and water-soluble vitamins. The treatment is based on anassumption that narcotics such as morphia cause toxicbodies to be formed in the body, and that these bodiesneutralise the narcotic and, in so doing, are themselvesneutralised. When the narcotic is withdrawn thesetoxic bodies cause withdrawal symptoms because theyare no longer being neutralised. Lambert and Tilneytherefore proposed that when a narcotic is withdrawnnarcosan should be given instead, in the hope thatthe lipoids which it contains will neutralise the toxicbodies, and thus prevent symptoms. The authors ofa recent paper 2 on drug-addiction consider that theresults of narcosan treatment are not consistent withthe hypothesis on which it is based, and quote evidenceto show that drug-addiction is associated with hypo-function of the endocrine system, secondary possiblyto disturbance of the sympathetic. According to thishypothesis, withdrawal symptoms are due to a func-tional upheaval in the endocrine system. They statethat the results of treatment with various endocrineextracts and also by hypodermic injection of solutionsof vegetable proteins, which are regarded as stimulantsof the endocrine system, confirm this hypothesis, andthey point out that one of the vegetable proteinsubstances (alfalfa protein) which they used as anendocrine stimulant is also present in narcosan. Itis suggested that the beneficial effects of the latterpreparation are due not to its ability to neutralisetoxic bodies formed in response to the narcotic, butrather to the stimulating effect of alfalfa protein onthe endocrine system. Acting on this assumption theytreated a series of drug-addicts with alfalfa proteinand obtained results similar in every way to thoseobtained with narcosan. Withdrawal symptoms wereslight and the patients remained in good physicalcondition. It seems probable, they say, that proteinsprepared from millet, rape, and hemp seed will giveequally satisfactory results, but recommend that allforms of protein treatment should be reinforced bysynchronous administration of orchitic and ovarianextracts, on the grounds that sexual function isinvariably affected in drug-addicts. An advantage ofalfalfa protein over narcosan is that it is very muchcheaper. ____

THE INCIDENCE OF GENERAL PARALYSIS

IN view of the reports from all sides which indicatethat mental disorder of every kind is on the increasein the United States, it is interesting to study thefigures for syphilis and general paralysis recently issuedby the United States Public Health Service to theOffice International.3 The incidence of syphilis amongthe general population is, of course, uncertain, but thepercentage of recruits giving a positive Wassermannreaction, out of a group of close on 12,000 in 1916 was13, and out of 856 candidates for the Washingtonpolice 15. The consensus of opinion puts the figure at10 per cent. for the whole population, but recentresearch has tended to lower it. The proportion ofgeneral paralytics to others in mental hospitals seems

1 Med. Jour. and Record, 1926, cxxiv., 764.2 The Proteal Treatment of Drug Addiction, by M. G. Carter,

T. J. Orbison, E. H. Steele, C. A. Wright, and E. H. Williams:Med. Jour. and Record, Sept. 7th, 1927, pp. 282-284.

3 Office International d’Hygiène Publique, Bulletin Mensuel,xix., 11.

Page 2: THE INCIDENCE OF GENERAL PARALYSIS

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high. St. Elizabeth’s Hospital in Washington admitted1558 general paralytics in a total of 26,500 entriesbetween 1886 and 1924, a percentage of 5-87. In1925-26 the percentage was 12-11. Census returnsgive the admission figures over the whole country as6-4 per cent. in 1910 and 7-9 per cent. in 1922, thoughthe proportion of ’general paralytics to other patientsactually in hospital in that year was 3-5 per cent.The number discharged cured was 0-5 per cent. ;13.5 per cent. were discharged improved, and 11-1 percent. unimproved. Of every 100 dying in hospital29-5 were general paralytics and 14-54 were sufferersfrom cerebral syphilis. The returns of 29 Statemental hospitals for 1925 showed a percentage of13’1 admissions for syphilitic psychoses, the individualfigures varying from 1-8 to 28-5 per cent. Theregistration bureau shows the proportion of deaths fromsyphilis to have remained at about 8 per 100,000 ofpopulation between 1914 and 1924 ; deaths fromgeneral paralysis were approximately 7 per 100,000during each year of the war, under six in 1919 and 1920,and about six and a half from 1921 to 1924. Treatmentby malaria seems to have yielded better results thanmost workers in this country dare to claim, for the i

figures given for the total remissions vary between35 and 70 per cent. Although the census returns do notshow a decrease in the incidence of general paralysismany medical sources report a decline, and this, ifactual, should make itself felt on the official returnsafter about five years. The incidence figures forjuvenile general paralysis are small. In 1910. outof 60,769 admissions to U.S.A. mental hospitals, only17 patients under 15 were diagnosed as generalparalytics. P. C. Jeans and J. V. Cooke, who examinedone-fifth of all the infants born in St. Louis during acertain period in 1921, put the incidence of congenitalsyphilis at 3 per cent., but out of the children of396 families examined between 1910-21 P. J. Whiteand B. Veeder only saw two cases of general paralysisand two of tabes dorsalis. In this country in 1925the number of patients resident in mental hospitalswas 106,403, and the death roll was 8029. The numberof general paralytics admitted in that year was 1218,or 1-14 per cent. of the residents ; the number of thosewho died was 1174, or 14-1 per cent. of the total deaths.Assuming a population of 45 million, the number ofdeaths from general paralysis is therefore about2-6 per 100,000, a figure considerably lower than the6-4 of the U.S.A. census for 1924, and the otherfigures are well below the corresponding ones furnishedby the American census. The inference is that generalparalysis, in common with most other mental andnervous conditions, has a higher incidence in theUnited States than in this country, but the reasons forthis are not as obvious as for the greater prevalence ofpsychogenic disorder.

Other figures, quoted by Dr. P. L. McKinlay in apaper on the relative incidence of general paralysisand locomotor ataxia among different social classes, 4give the average death-rate from general paralysis as9-07 per 100,000 during the three-year period 1910-12,for which the American figure is only 6-3. Contrary tothe usual belief, Dr. McKinlay finds that generalparalysis is proportionately more frequent in thelower than in the upper occupational classes. Thismight seem to dispose of the theory that this form ofneuro-syphilis is determined largely by excessivebrain-work. It has long been suspected that somelaw, and not mere chance, governs the form whichtertiary syphilis shall take in a given patient, and itwas Dr. McKinlay’s object to discover, if possible, thesignificance of occupation and other social factors.He quotes the conclusion of Mott that stress on thoseparts of the nervous system that are most in use is animportant element. In a majority of general para-lytics Mott found that the gross wasting of the leftcerebral hemisphere was greater than that of the right,and out of 60 successive such cases of tabes dorsalisonly two were not engaged in occupations involvingstress of the lower limbs. The fact that his statistics

4 Jour. of Hyg., 1928, xxvii., 174.

prove the opposite of the popular view may, he thinks,be due to error in the premises on which that view isbased. Statistics derived from general hospitals onthe social incidence of disease are apt to be vitiatedby the selective methods employed. Perhaps the mosttelling argument, however, against the generalimpression is that it leaves out of account a host offactors like alcohol, which according to Mott, favoursthe onset of general paralysis while it merely acceleratestabes, and the higher incidence of syphilis among thelower strata of the population. Only when statisticsare modified by this factor will they have any realvalue.

--

TANNIC ACID IN THE TREATMENT OF BURNS.

THE suffering caused by extensive burns is so

intense and the danger to life is so grave that medicalmen cannot rest satisfied with the means at theirdisposal for treating the victims. We publish onp. 336 an article by Dr. R. M. Gordon on the use oftannic acid, which in his experience efficiently com-bats toxsemia by preventing the absorption of toxicproducts, as well as soothing pain and lessening scarformation. In a recent issue of the Canadian MedicalAssociation Journal (1927, xxii., 1357) Dr. JohnHunter records the case of a girl who was severelyburned on the face, neck, and arms as the result of agasoline explosion. The fire brigade applied a first-aid dressing of picric acid and a young doctor removedthis and substituted carron oil. Next morning Dr.Hunter found that the carron oil dressing was causingintense pain and profuse discharge. He thereforesprayed on a watery solution of 2 per cent. tannicacid, leaving a coating a quarter of an inch thick. Nobandage was used and the acid was left to peel off,which it did in about three weeks’ time. Relief wasinstantaneous and the discharge was lessened.Although pus oozed out from under the dressing therewere no toxic effects. Shock was minimised byheat, stimulants, rest, and diathermy, and as soon aspossible the affected areas were exposed to sunlight.The result was eminently satisfactory, and Dr. Hunterconcludes that tannic acid is the treatment of electionfor burns.

____

THE MOTT MEMORIAL.

THE response made to an appeal by the Councilof the Royal Medico-Psychological Association to thecolleagues, friends, admirers, and former pupils ofthe late Sir Frederick Mott, for their coöperation inthe publication of a Memorial Book has been such asto encourage the Council to proceed with the proposal.The Council has appointed a Memorial Committeeconsisting of Dr. C. Hubert Bond, Dr. F. L. Golla,Dr. Douglas McRae, Dr. Thomas Beaton, and Lieut.-Colonel J. R. Lord (hon. secretary). Neurologists,psychiatrists, and pathologists in Canada, the UnitedStates, and Japan, as well as in this country and onthe continent of Europe, have promised to con-

tribute papers to the Memorial Book, which promisesto be of high intrinsic scientific value and shouldworthily perpetuate the memory of one who did somuch to elucidate the dark corners of neuropathology.The Committee have opened a fund which will bedevoted primarily to the publication of the MemorialBook. Donations should be sent to the Treasurer,Dr. James Chambers, The Priory, Roehampton,London, S.W. 15. A donation of not less than18s. 6d., if subscribed before publication, will entitle

the donor to a free copy of the work when it appears.ROYAL COLLEGE OF PHYSICIANS OF LONDON :CONFERMENT OF HONORARY FELLOWSHIPS.

THE Royal College of Physicians is celebrating onMay 14th next and following days the tercentenaryof the publication of William Harvey’s book " DeMotu Cordis," an event that laid the foundation-stoneof modern physiology and scientific medicine. Dele-

gates and distinguished guests from all parts of theworld have been invited to participate in an interesting


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