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The Nobel Prize in Physiology or Medicine 2011 · PDF file1 1 2 2 The immune system Innate...

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1 1 2 2 The immune system Innate immunity Adaptive immunity Adaptive immunity Innate immunity rapid halts infection no memory slower clears infection memory Components of microorganisms bind to Toll-like receptors located on many cells in the body. This activates innate immunity, which leads to inflammation and to the destruction of invading microorganisms. Dendritic cells activate T lymphocytes, which initiates adaptive immunity. A cascade of immune reactions follows, with formation of antibodies and killer cells. TLR Microorganism Dendritic cell T lymphocytes Infection of the human body by pathogenic microorganisms such as bacteria, viruses, parasites or fungi triggers the immune response. It occurs in a two-step process: innate immunity halts the infection, and adaptive immunity subsequently clears it. The Nobel Prize in Physiology or Medicine 2011 © 2011 The Nobel Committee for Physiology or Medicine The Nobel Prize® and the Nobel Prize® medal design mark are registered trademarks of the Nobel Foundation Illustration: Mattias Karlén
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Page 1: The Nobel Prize in Physiology or Medicine 2011 · PDF file1 1 2 2 The immune system Innate immunity Adaptive immunity Innate immunity Adaptive immunity rapid halts infection no memory

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The immune system

Innate immunity Adaptive immunity

Adaptive immunityInnate immunityrapid

halts infectionno memory

slowerclears infection

memory

Components of microorganisms bind to Toll-like receptors located on many cells in the body. This activates innate immunity, which leads to inflammation and to the destruction of invading microorganisms.

Dendritic cells activate T lymphocytes, which initiates adaptive immunity. A cascade of immune reactions follows, with formation of antibodies and killer cells.

TLR

Microorganism

Dendritic cell

T lymphocytes

Infection of the human body by pathogenic microorganisms such as bacteria, viruses, parasites or fungi triggers the immune response. It occurs in a two-step process: innate immunity halts the infection, and adaptive immunity subsequently clears it.

The Nobel Prize in Physiology or Medicine 2011

© 2011 The Nobel Committee for Physiology or Medicine The Nobel Prize® and the Nobel Prize® medal design mark are registered trademarks of the Nobel Foundation

Illustration: Mattias Karlén

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