The Pain Market:

Spain Core Therapeutic ReportNational Health and Wellness Survey 2010

2

Method and Sample

Data Collection+ Survey administered via the Internet since 2002+ Data collected during March-May 2010+ Countries: Spain

Sample+ Adults 18+ years of age+ Sample drawn from the Internet panel maintained by Lightspeed Research+ Invitations to participate sent to a sample stratified according to:

– Gender– Age

Results are projected to reflect the total population using known population incidences for key subgroups

+ Weighting Variables: Gender and age+ From the International Data Base of the U.S. Census Bureau and

Organization for Economic Cooperation and Development

3

Sample Spain Population

(n)Projected Number of

Spain AdultsTotal Spain Adults 5,039 35.4 MExperiencing Pain (in the past month)* 868 6.1 MSevere 100 714 K

Moderate 554 3.9 M

Mild 214 1.5 M

Severe:Rx 81 572 K

OTC‡ Only 10†† 73 K

Untreated 9†† 68 K

Moderate:Rx 357 2.6 M

OTC‡ Only 106 710 K

Untreated 91 622 K

Mild:Rx 77 551 K

OTC‡ Only 81 549 K

Untreated 56 374 K

Spain Sample Size

Key segments of the Pain market are represented by the following sample sizes:

††Caution: extremely small base size ‡OTC/Herbal Products*Excludes dental problems, headache, menstrual pain or migraine only.

Spain Pain Prevalence 2010

4††Base too small to project to total population (n<15) ‡OTC/Herbal ProductsQuestions reference for this slide include: HH10, HH20, PN5, PN15, PN20, PN95, PN120, DB40 (See Appendix)

*Excludes dental problems, headache, menstrual pain or migraine only.

Experiencing Pain (in the past month)*

6.1 M (17%)(n=868)

SEVERE714 K (12%)

(n=100)

Use Rx572 K 80%

(n=81)

OTC‡ Only73 K 10%

(n=10††)

Untreated68 K 10%

(n=9††)

MODERATE3.9 M (64%)

(n=554)

Use Rx2.6 M 66%

(n=357)

OTC‡ Only710 K 18%

(n=106)

Untreated622 K 16%

(n=91)

MILD1.5 M (24%)

(n=214)

Use Rx551 K 37%

(n=77)

OTC‡ Only549 K 37%

(n=81)

Untreated374 K 25%

(n=56)

Total Spain Adults Population

35.4 M(n=5,039)

All OTC‡ Users191 K (27%)

(n=26†)

Total Use Rx572 K 80%

(n=81)

Spain Pain Brand Usage 2010

Experiencing Pain (in the past month)*6.1 M (17%) (n=868)

SEVERE714 K (12%)

(n=100)

*Excludes dental problems, headache, menstrual pain or migraine only.‡OTC/Herbal Products†Caution: small base (n<30)††Base too small to project to total population (n<15) Questions reference for this slide include: HH10, HH20, PN5, PN15, PN20, PN30, PN95, PN100, PN120 , DB40 (See Appendix)

5

Specific Rx Therapies Used(By Class of Drug)

Strong Opioids †† (n=12†) Weak Opioids 294 K 51% (n=39) NSAIDs 362 K 63% (n=52) COX-2s †† (n=7†) Anticonvulsants 155 K 27% (n=23†) Amitriptyline †† (n=0†) Analgesics †† (n=14†) All Other Pain Medications †† (n=4†)

Top OTC‡ Therapies Used(Unaided)

Ibuprofen Products †† (n=13†) Acetaminophen /Paracetamol †† (n=2†) Aspirin Products †† (n=0†)Diclofenac †† (n=0†) Others(inc. combination OTCs‡) †† (n=10†)

MODERATE3.9 M (64%)

(n=554)

Total Use Rx2.6 M 66%

(n=357)

Total OTC‡ Users 1.3 M (32%)

(n=180)

MILD1.5 M (24%)

(n=214)

Total Use Rx551 K 37%

(n=77)

Total OTC‡ Users 620 K (42%)

(n=91)

Specific Rx Therapies Used(By Class of Drug)

Strong Opioids †† (n=3†) Weak Opioids 1.1 M 43% (n=143) NSAIDs 1.8 M 71% (n=261) COX-2s 126 K 5% (n=20†) Anticonvulsants 245 K 10% (n=34) Amitriptyline †† (n=0†) Analgesics 351 K 14% (n=55) All Other Pain Medications †† (n=13†)

Specific Rx Therapies Used(By Class of Drug)

Strong Opioids †† (n=0†) Weak Opioids 126 K 23% (n=18†) NSAIDs 418 K 76% (n=60) COX-2s †† (n=2†) Anticonvulsants †† (n=2†) Amitriptyline †† (n=0†) Analgesics †† (n=5†) All Other Pain Medications †† (n=3†)

Top OTC‡ Therapies Used(Unaided)

Ibuprofen Products 824 K 66% (n=124) Acetaminophen /Paracetamol 406 K 32% (n=59) Aspirin Products 187 K 15% (n=23†)Diclofenac †† (n=5†) Others(inc. combination OTCs‡) 621 K 50% (n=93)

Top OTC‡ Therapies Used(Unaided)

Ibuprofen Products 392 K 63% (n=59) Acetaminophen /Paracetamol 167 K 27% (n=26†) Aspirin Products 128 K 21% (n=18†)Diclofenac †† (n=3†) Others(inc. combination OTCs‡) 292 K 47% (n=44)

Total Spain Adults Population35.4 M (n=5,039)

6

Experiencing Pain in Past Month*

Total Rx Users

Strong Opioids

Weak Opioids NSAIDs COX-2s

AntiConv-ulsants

Amitri-ptyline Analgesics

All Other Pain

Medication3.7 M 125 K 1.5 M 2.6 M 182 K 412 K 0 K 488 K 144 K

(n=515) (n=15†) (n=200) (n=373) (n=29†) (n=59) (n=0††) (n=74) (n=20†)

Duration of Rx Usage (mean # of months)Experiencing Pain (in the past month)* 67.8 26.7 59.3 68.8 33.2 33.4 - 64.1 65.5Severe 81.1 32.6 79.7 92.3 57.3 40.5 - 55.3 94.5Moderate 69.9 7.5 57.1 69.4 26.9 30.2 - 69.5 44.0Mild 44.4 - 31.7 46.1 7.1 9.4 - 33.5 93.9% Extremely/Very SatisfiedExperiencing Pain (in the past month)* 40% 31% 31% 43% 37% 46% - 45% 52%Severe 32% 39% 29% 28% 31% 33% - 28% 79%Moderate 40% - 32% 43% 40% 51% - 47% 23%Mild 55% - 21% 59% 31% 100% - 84% 100%# Days/Mo. Report Taking Rx (mean)Experiencing Pain (in the past month)* 16 21 15 12 13 24 - 16 16Severe 23 21 20 18 15 25 - 18 19Moderate 16 20 14 12 14 24 - 16 20Mild 8 - 8 7 8 15 - 14 4% Requested Specific RxExperiencing Pain (in the past month)* 29% 25% 26% 28% 14% 11% - 29% 26%Severe 27% 24% 30% 26% 17% 16% - 33% 46%Moderate 28% 26% 22% 27% 10% 9% - 27% 24%Mild 36% - 45% 35% 44% - - 40% 17%

Pain Prescription Medication Usage

Pain Prescription Medication Usage(Experiencing Pain and using Rx)*

*Excludes dental problems, headache, menstrual pain or migraine only. Caution: †small base size; ††extremely small base size*Note: mean satisfaction taken into consideration if multiple pain therapies are used.PN35: You indicated you use the following prescription medication(s). Did you request this specific brand from your doctor?.PN40: How many years and/or months have you been using these prescription medication(s)? If you have been using it less than 1 month, please enter a “0” for ”years” and “1” for “months”.PN45: How many days did you use these prescription medication(s) in the past month?PN50: How satisfied are you with these prescription medication(s)?Based on 7 point scale where 1=Extremely dissatisfied and 7=Extremely satisfied In 2010, a "stacked" method was used for determining overall medication satisfaction

Comparison of SF-12v2 Physical/Mental Health Scores by Subgroups to Total Population Score

7

‡OTC/Herbal Products Caution: extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only.General Health - summary scores.Letters indicate statistically significant difference @ 95% confidence level between subgroups

Physical Health Summary Mental Health Summary

Spain Total Population Score Mean=48.4

Total Spain Adults(35.4 M; n=5,039)

Experiencing Pain (in the past month)*(6.1 M; n=868)

Severe (C)

(714 K; n=100)

Mild (E)

(1.5 M; n=214)

Moderate (D)

(3.9 M; n=554)

Expe

rienc

ing

Pain

(in

the

past

mon

th)*

Rx (L)

(551 K; n=77)OTC‡ Only (M)

(549 K; n=81)Untreated (N)

(374 K; n=56)

Seve

re:

Spain Total Population Score Mean=47.4

C

Rx (F)

(572 K; n=81)OTC‡ Only (G)

(73 K; n=10)Untreated (H)

(68 K; n=9)Rx (I)

(2.6 M; n=357)OTC‡ Only (J)

(710 K; n=106)Untreated (K)

(622 K; n=91)Mod

erat

e:M

ild:

CD

I

I

L

C

CD

8

Pain Interfered With Normal Work During The Past 4 Weeks

Total Spain Adults

Exp. Pain (in the past

month)*

Experiencing Pain (in the past month)* Severe Moderate Mild

Severe (C)

Moderate(D)

Mild(E)

Rx(F)

OTC‡ Only(G)

Untr-eated

(H)Rx(I)

OTC‡ Only(J)

Untr-eated

(K)Rx(L)

OTC‡ Only(M)

Untr-eated

(N)35.4 M 6.1 M 714 K 3.9 M 1.5 M 572 K 73 K 68 K 2.6 M 710 K 622 K 551 K 549 K 374 K

(n=5,039) (n=868) (n=100) (n=554) (n=214) (n=81) (n=10) (n=9) (n=357) (n=106) (n=91) (n=77) (n=81) (n=56)General HealthExtremely 2% 6% 35%DE 2% 0% 34% 30% 53% 3% 2% - 1% - - Quite a bit 8% 23% 48%DE 26%E 4% 52% 34% 26% 32%JK 15% 15% 5% 4% 2%Moderately 17% 27% 13% 31%CE 22% 11% 27% 11% 32% 27% 31% 28% 16% 19%A little bit 32% 36% 4% 34%C 58%CD 3% 9% 10% 30% 40% 42%I 57% 61% 56%No at all 42% 8% - 7% 16%D - - - 3% 16%I 11%I 9% 19% 23%L

Pain Interfered With Normal Work During The Past 4 Weeks

‡OTC/Herbal Products Caution: extremely small base size Zero % implies a very small value less than 0.5%*Excludes dental problems, headache, menstrual pain or migraine only. GH25: During the past 4 weeks, how much did pain interfere with your normal work (including both work outside the home and housework)?(1-5 Scale: 1=Excellent and 5=No at all)Letters indicate statistically significant difference @ 95% confidence level between subgroups

9

Physical Health Or Emotional Problems Interfered With Social Activities During The Past 4 Weeks

Total Spain Adults

Exp. Pain (in the past

month)*

Experiencing Pain (in the past month)* Severe Moderate Mild

Severe (C)

Moderate(D)

Mild(E)

Rx(F)

OTC‡ Only(G)

Untr-eated

(H)Rx(I)

OTC‡ Only(J)

Untr-eated

(K)Rx(L)

OTC‡ Only(M)

Untr-eated

(N)35.4 M 6.1 M 714 K 3.9 M 1.5 M 572 K 73 K 68 K 2.6 M 710 K 622 K 551 K 549 K 374 K

(n=5,039) (n=868) (n=100) (n=554) (n=214) (n=81) (n=10) (n=9) (n=357) (n=106) (n=91) (n=77) (n=81) (n=56)General HealthAll of the time 2% 4% 24%DE 2% 1% 27% 8% 11% 3% - 1% - 3% - Most of the time 8% 13% 29%DE 12%E 7% 30% 27% 18% 14% 8% 10% 10% 5% 7%Some of the time 19% 27% 28% 29% 22% 26% 38% 28% 34%JK 23% 16% 22% 20% 26%A little of a time 30% 30% 13% 31%C 36%C 14% 17% - 28% 34% 42%I 42% 38% 25%None of the time 41% 25% 7% 24%C 33%CD 3% 9% 42% 20% 35%I 32%I 26% 34% 42%

Physical Health Or Emotional Problems Interfered WithSocial Activities During The Past 4 Weeks

‡OTC/Herbal Products Caution: extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only. GH35: During the past 4 weeks, how much of the time has your physical health or emotional problems interfered with your social activities (like visiting friends, relatives, etc.)? (1-5 Scale: 1=all of the time and 5=None of the time)Letters indicate statistically significant difference @ 95% confidence level between subgroups

10

‡OTC/Herbal Products ^Differing base size Caution: extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only. All the figures are for presently Full Time employees apart from activity impairmentDE30: What is your employment status?WPPCTWRK: Percentage work time missed due to health. WPIMPAIR: Percentage impairment while working due to health.WPWRKIMP: Percentage overall work impairment due to health. WPACTIMP: Percentage activity impairment due to health.(0-10 Scale: 0=health problems had no effect on my work and 10=health problems completely prevented me from working)Letters indicate statistically significant difference @ 95% confidence level between subgroups

Spain Adult Work Productivity and Activity Impairment

Total Spain Adults

Exp. Pain (in the past

month)*

Experiencing Pain (in the past month)* Severe Moderate Mild

Severe (C)

Moderate(D)

Mild(E)

Rx(F)

OTC‡ Only(G)

Untr-eated

(H)Rx(I)

OTC‡ Only(J)

Untr-eated

(K)Rx(L)

OTC‡ Only(M)

Untr-eated

(N)35.4 M 6.1 M 714 K 3.9 M 1.5 M 572 K 73 K 68 K 2.6 M 710 K 622 K 551 K 549 K 374 K

(n=5,039) (n=868) (n=100) (n=554) (n=214) (n=81) (n=10) (n=9) (n=357) (n=106) (n=91) (n=77) (n=81) (n=56)Employed full time 37% 34% 20% 33%C 45%CD 25% - - 29% 43%I 37% 41% 50% 44%Absenteeism^% work time missed due to health – past 7 days (mean)

4.6 12.7 41.8DE 12.8 6.3 41.8 - - 17.7J 2.3 11.2 7.1 5.7 6.1

Presenteeism^% impairment while working due to health (mean)

17.1 25.1 38.3 25.4 22.9 38.3 - - 28.6 21.1 22.1 25.2 21.4 22.3

Work Productivity Loss^% overall work impairment due to health (mean)

20.1 33.6 62.8DE 33.9 26.6 62.8 - - 40.1J 21.4 30.5 29.6 24.4 26.3

Activity Impairment% activity impairment due to health (mean)

25.6 41.7 74.4DE 41.6E 26.0 79.2 61.5 47.7 47.2JK 27.0 35.2J 30.6N 24.9 20.9

Spain Adult Work Productivity and Activity Impairment

61%

40%

29%

35%

17%

12%

10%

10%

23%

7%

Type of Pain Conditions

11*Excludes dental problems, headache, menstrual pain or migraine only.PN15: Please indicate which of the following conditions have caused you to feel pain in the past month.Letters indicate statistically significant difference @ 95% confidence level between subgroups

Pain population, prevalence of conditions causing pain by pain severity(Respondents with pain in the past month)

Experience Pain(in the past month)*

(6.1 M; n=868)Moderate (D)

(3.9 M; n=554)Mild (E)

(1.5 M; n=214)

Experiencing Pain (in the past month)*

Back pain

Headache

Shoulder pain/stiffness

Arthritis pain

Neck pain

Migraine

Dental pain

Sprains or strains

Surgery or medical procedure

Joint pain

13%

15%

15%

12%

17%

28%

15%

13%

16%

29%

67%

66%

66%

64%

66%

57%

71%

57%

67%

63%

19%

19%

19%

24%

16%

15%

14%

31%

17%

8%

Severe (C)

(714 K; n=100)

12

Experience Symptoms/Side Effects – Among Rx Opioid Users

Experience Symptoms/Side Effects – Among Rx Opioid Users(Respondents with pain in the past month (qualified respondents), taking opioid medications, experiencing symptoms)

Nausea

Experience Pain(in the past month)*

(239 K; n=37)Severe (C)

(77 K; n=12††)Moderate (D)

(149 K; n=23†)Mild (E)

(13 K; n=2††)

Experiencing Pain (in the past month)*

Abdominal pain / discomfort

Dizziness

Constipation

Sleepiness

Trouble thinking clearly

Other digestive symptoms

Vomiting

Feeling moody, irritable, anxious, or restless

Diarrhea

Bloating

Other

None of above

Caution: †small base size; ††extremely small base size *Excludes dental problems, headache, menstrual pain or migraine only.PN60: Please indicate the symptoms you experience while taking <insert name(s) of opioid medication> for your pain?No statistically significant difference @ 95% confidence level between subgroups

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

13

CONTACT INFORMATION Global Headquarters

Kantar Health Health Sciences Practice1 Independence Way, Suite 220, Princeton, NJ  08540Telephone: +1 (609) 720 5480 Fax: +1 (609) 720 5481

11 Madison Avenue, 12th Floor, New York, NY 10010 Telephone: +1 (212) 706 4279 Fax: +1 (212) 647 7659

Spain NHWS 2010 Data

When referencing data from this report please use the following citation:

+ Kantar Health. September 2010. NATIONAL HEALTH AND WELLNESS SURVEY, 2010 [Spain]. Princeton, NJ.