Robert H. Vonderheide, MD, DPhil

Director Abramson Cancer Center

Perelman School of Medicine

University of Pennsylvania

The Cancer Genetics Era

Peter C. Nowell, MD 1928-2016

Revolutionized our understanding of cancer

Stroma Metabolism Epigenome

Germline

Big data

Deep data

Proteome

Genetics

Immune System

Vasculature

Tumor cell

The Cancer Ecology Era

The Cancer Immune Revolution: T cells attack cancer

T cell Tumor

cell

CAR T cell FDA-approval Flash Mob at Penn

August 30, 2017

Find Driver Tumor Mutations

Match to Targeted Therapies

Find All Tumor Mutations and Proteins

Identify Immune Targets

Identify all the surrounding immune cells and immune checkpoints

Precision Oncology

CANCER WORKUP

Now

Next

Tumor Genetics Cancer Immunology

Routine Medical Workup

Echo

Blood tests

EP test

EKG

Cath

HEART

Bronch Chest

CT

Chest Xray

PFTs

LUNG

Neuro-psych tests

EEG MRI

Head CT

BRAIN

Blood tests

Ultra-sound Urine

test

KIDNEY

Blood tests

Ultra-sound Colon-

oscopy

GI TRACT

White blood count

IMMUNE

Immune profiling

Immunotherapy drugs

Biosamples

Cellular immunotherapy

“Immune Health”

Bioinformatics