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Can genomics, facilitated by NGS and cloud computing, enhance phytomedicine in early stage R&D? Will Spooner, CTO, Founder, Eagle Genomics Ltd [email protected]
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Can genomics,
facilitated by NGS and cloud computing,
enhance phytomedicine in early stage R&D?
Will Spooner, CTO, Founder, Eagle Genomics [email protected]
Molecular Psychiatry advance online publication 30 August 2011; doi:10.1038/mp.2011.101
Scientific impact of genomics
Image: Sartr http://sartr.deviantart.com/gallery/?offset=96#/d1u0z75 CC BY-NC-ND 3.0
Phen
otyp
e As
soci
ation
PhenotypicAssociation[biomarker]
Stratified Medicine
Right drug
Right patient
Right time
Pharmacogenomics
Genotypic
Transcriptomic
Epigenetic
Genomics in pharmacology
©
Genomics in plant breedingGermplasm/Pedigree
Phenotype/Genotype association
Phenotype Genotype
GenotypingPhenotyping
Assays
Breeding
Plant models for lead optimisation
Image By: G. Nicolella http://luirig.altervista.org/cpm/albums/bot-002/normal_medicago-truncatula3637.jpg CC BY SA
Physcomitrella patens
Image By: Ralf Reski CC BY-ND
Aquilegia coerulea
Sequenced phytomedicinal plants
Cannabis sativa
Theobroma cacao Ricinus communis
Image By: Actv [CC] Image By: Eric Lyons
Image By: Kai Yan, Joseph Wong [CC] Image By: Howard F. Schwartzs [CC]
Genomics in research productivity
Apoptotic execution Phase
Synergy in phytopharmacology
2 + 2 = more
NGS - democratising genomics
The Cost of Big Data
Now Soon
Image: PictureGirl http://pixdaus.com/single.php?id=256700 CC-BY-SA
Cloud Computing = Greater ScalabilityCloud Computing = Lower Cost
+ Greater agility+ More flexibility+ Faster time to market+ Improved business process
Open Innovation
ExploreWork together to find a commonpurpose
NurtureBuild trust, shared language
ExploitTurn ideas intotangible benefits
CollaborateEnterpriseAcademiaGovernmentFoundations
Pre-Competitive Collaboration
©
Ensembl as a GCMS
Comparative Genomics
Functional Genomics
Variation
Assembly/GenesData Integration
Data Reporting
Data Analysis
Data Integration
Data Querying
Data QC
API
Leveraging Public Resources
Summary
• Genomics is revolutionising:– Basic research, – Plant breeding, – Pharma R&D
• Genomics can be applied to phytomedicine:– Lead discovery/optimisation,– Study of mode of action/synergy
• Genomics R&D is empowered by:– NGS, – Cloud computing, – Open innovation.
Questions and Comments
[email protected] @wspoonrON EMAIL
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