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Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation...

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Topic 8-2 Other Antibiotics Ch 16 Patrick P157- Infectious disease chapter- Corey
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Page 1: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Topic 8-2 Other Antibiotics

Ch 16 PatrickP157- Infectious disease chapter-

Corey

Page 2: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Other cell wall inhibitors

Page 3: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Vancomycin

Page 4: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Protein synthesis inhibitors

Page 5: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Protein synthesis translationinhibitors

Page 6: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Protein synthesis translationinhibitors

Page 7: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Protein synthesis translationinhibitors

Erythromycin

•Binds 50S ribosome•Low toxicity•Enteric coated to prevent aciddamage(ketal formation)

Page 8: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Transcription and replicationinhibitors

Quinoline antibiotics

•Topo inhibitors•Gr + and Gr- esp Pseudomonas•Cipro is one of the best broadspectrum antibiotics•Used for resistant strains•Resistance forms due to effluxpumps mostly

Page 9: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Rifamycins• RNA polymerase inhibitor,

Gr+ activity• Used for tuberculosis,

leprosy and resistantbacterial strains

• Can adversely effect otherdrugs (like HIV protease) byinducing CYP3A

Page 10: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Drug resistance pumps

Page 11: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Drug resistance pump assembled!


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