Protein synthesis translationinhibitors
Erythromycin
•Binds 50S ribosome•Low toxicity•Enteric coated to prevent aciddamage(ketal formation)
Transcription and replicationinhibitors
Quinoline antibiotics
•Topo inhibitors•Gr + and Gr- esp Pseudomonas•Cipro is one of the best broadspectrum antibiotics•Used for resistant strains•Resistance forms due to effluxpumps mostly
Rifamycins• RNA polymerase inhibitor,
Gr+ activity• Used for tuberculosis,
leprosy and resistantbacterial strains
• Can adversely effect otherdrugs (like HIV protease) byinducing CYP3A