Towards an Understanding and Practice of Intravenous Orthomolecular Treatments for Mental Illnesses

8/3/2019 Towards an Understanding and Practice of Intravenous Orthomolecular Treatments for Mental Illnesses

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Towards an Understanding

and Practice of Intravenous

Orthomolecular Treatments

for Mental Illnesses

Bradford S. Weeks, M.D.

www.weeksmd.com

[email protected]



Introduction

My thanks - powerpoint

Topic: Setting the stage for IV therapies

We will learn how to optimize orthomolecular

treatment including IV protocols – the do’s

and don’t.

How do we learn? Books? Experience?

Teachers: Paracelsus, Steiner, Hoffer et al







Orthomolecular Medicine and

Psychiatry’s Practice

Orientation and Goals

1) Behold the suffering patient

as an individual person worthy of our respect

who is working out his or her destiny and is

honoring us by asking for the best we can offer to

help the patient along the way;

2) Reduce the Toxins

3) Replenish the Beneficials



What is Orthomolecular?

Imagine sitting on a park bench and gettinga splinter. Up come two doctors, one withpain medications and one with tweezers.

The doc offering to remove the splinter anddressing the wound (perhaps with raw

honey) is the orthomolecular doctor.

“…using the correct molecules in thecorrect dosage…” Linus Pauling, Ph.D.



Ortho… - Spirit

- Soul- Etheric

- Physical Structure

Molecular (Drs. Hoffer, Pauling et al)



O M & P as “Inventory Control”

Spirit - decision - values - constant

Soul - feelings – passion - changeable

Life force - etheric - chi -biorhythms

Physical Body - matter – substance - biochem

“There is no matter without spirit and there is nospirit without matter.”

Dr. Rudolf Steiner



A Violin Recital needs:

A violin - the instrument (physical body) Someone to tune the violin (etheric body)

Someone who enjoys playing music (the soul)

Someone who once created a sonata or who can

improvise extemporaneously (the spirit)



A Successful Sailing Voyage

Requires:

A Boat (the physical body)

Calk for the wood and patches for the sail

(the etheric or regenerative body)

Wind which is changeable (the soul)

A Rudder to stay the course despite changes

in wind and weather (the spirit)



Spirit

Not necessarily what church one attends.

Who do you see in the mirror?

What do you stand for?

What are you committed to? What would you fight for?

What do you want on your tombstone?



“What virtually all cancer survivors,

particularly the ones that had beenundergoing conventional therapies,

have in common is that they had

a purpose to their lives with goalsthey absolutely needed to achieve,

…….no matter what.”

A.H. Sartori, M.D.

personal correspondence 2-04



Soul Body

Soul Food

Inconstant

Depleting

Catabolic

Burning the candle (at both ends!)

Dominant when awake



“We term sleep a death;and yet it is waking that kills

us, and destroys those spiritsthat are the house of life.”

Thomas Browne , 1643



Etheric Body

Chi

Rhythm

Restorative

Regenerative

Anabolic Waxing the candle

Dominant during sleep



“That we are not much

sicker and much madder than we are is due

exclusively to that most blessed and blessing of all

natural graces, sleep”.

Aldous Huxley



Physical Body

Structure and Molecule

Posture and Function

Tissue and Biochemistry



Substance Inventory Control

Toxins / Stressors

Pollution

– Electromagnetic

– Heavy metals (Hg, Pb, As etc.)

– Pesticides (xenoestrogens)

– Air

– Water

Hypoglycemia (popping the clutch)

Sleep disturbances

Addictive agents

Pharmaceuticals (if inappropriate)

The Daily News

Beneficials

Oxygen

– Open Airway

– Exercise for cleansing

Water

– ½ your weight in ounces AWAY from

food Nutrients

– Organic Food

– Supplements

– Enzymes

– Digestive Aids



Orthomolecular

Medicine and Psychiatry Which is is?

-Trickle up (the part conditions the whole -ie. the molecules effect mood)

or

- Trickle down (the whole determines the part – ie. the mood effects the molecules)

Answer: both





ORTHO







Doctor as Good Samaritian

At the side of the road…

(and while taking a history in the office),

remember your A, B, C’s !

Airway, Breathing, Circulation



Conditions Ameliorated

Autism, Anxiety, ADHD, Apnea

Bruxism

Cancer, Chronic Fatigue Syndrome

Depression, Diabetes

Eczema

Fibromyalgia, Fatigue

Insomnia



Conditions Ameliorated

Multiple Sclerosis

Neuropathies ArthritisParkinson’s Panic Attacks

Schizophrenia SnoringTourette’s Syndrome



CARDIOVASCULAR AND

SLEEP-RELATED CONSEQUENCESOF TEMPOROMANDIBULAR

DISORDERS

NHLBI WORKSHOP

National Heart, Lung and Blood Institute NHLBI

NHLBI Division of Heart and Vascular Diseases DHVD

NHLBI National Center on Sleep Disorders Research NCSDRDecember 3-4, 2001 Bethesda, Maryland

FINAL REPORT



Inscription from Machavelli's Tomb

"There is nothing more difficult to take

in hand, more perilous to conduct, ormore uncertain in its success, than to

take the lead in the introduction of a

new order of things."



Farrand Robson, DDS

Oral Systemic Balance (OSB)

Tacoma, Washington

[email protected]

http://www.oralsystemicbalance.com

mailto:[email protected]

http://www.oralsystemicbalance.com/

http://www.oralsystemicbalance.com/

mailto:[email protected]



ORAL SYSTEMIC BALANCE

• Homeostasis

– The equilibrium maintained by complexbiological mechanisms via the autonomic nervous

system to offset disrupting changes.

• Oral Systemic Balance

– The equilibrium between the mouth and the rest

of the body via the autonomic nervous system

needed to offset disruptive changes.



THE MOUTH AND JAW

IN NEUROMUSCULAR CONTROL

OF THE THROAT

Holds The Tongue

Maintain The Throat Supports The Ease of Oral Functions

– Breathing

– Swallowing

– Speaking

Are An Integral Part Of Homeostasis As They

Contribute To The Oral Systemic Balance.



Case Study

11 year old boy in a wheelchair

DX: MS, RA, ALS, toxic in vitamin A,

malingering (father too)

Disposition: see a psychiatrist

Stroke of Luck: saw a dentist



Patient Heal Thyself

Father read about a cure in Second Opinion

Called the featured dentist, Farrand Robson

Son was treated within the week

Son arrived in a wheel chair and left

walking (pushing his wheelchair)

…… 5 hours later!























Lateral Cephalometric Films

SEE: throat closed vs. throat open

Case Study: 11 year old leukemia patient

s/p chemotherapy with nausea, marked leg

and head pain, heart rate of over 150 since

chemo began. All these Sx resolved with OSB.









True Diagnosis:

Airway Obstruction… “Choking”

Etiology:

Corrective Dental Surgery (cleft palate) shrunk themouth leaving

“A 10 gallon tongue in a 5 gallon mouth”

LESSON: Choking causes autonomic dys-regulation which manifests as medical andpsychiatric illnesses - check the airway…A,B,C’s!



Etiology:

“If it weren’t for we dentists,

you medical doctors

would have nothing to do…”

Hal Huggins, DDS

-personal correspondence, 1988

THE MOUTH AND JAW



THE MOUTH AND JAW

IN NEUROMUSCULAR CONTROL

OF THE THROAT

Holds The Tongue

Maintain The Throat (airway)

Supports The Ease of Oral Functions

Are An Integral Part Of Homeostasis as

Oral Systemic Balance is primary.

The Dentist holds the ANS in his hands.

EPINEPHRINE FACILITATION



EPINEPHRINE FACILITATION

OF

JAW Muscle Function

Intense, active, or collapse

Feels on edge when at restFeels on edge when distracted

Functions well with moderate

stressors – creates “stress” when on

vacation…



The jawbone’s connected

to the….

Autonomic Nervous System and the whole

Unhappy Tongue goes into spasm and

retreat to guard the throat – back and down

obstructing airway



What makes a Tongue unhappy ?

Being Cramped

(braces, retainers)

Cosmetic dental procedures

(tongue forms the teeth for a reason)

Pregnant crowns

(block tongue coming up and out

of the throat)



The Role of the Tongue

Remember the homunculus…

A particular body region isrepresented on the cortex with an

area that is proportional to thedensity of touch receptors in thebody part, not by its actual size.



The Primacy of the Tongue

“48%” of the sensory cortex is

devoted to coordinating tongue and

jaw movements in order to

GUARD the THROAT and prevent

CHOKING.











The new ORAL history

Stressed out…. but feel better with a little

stress? Unable to relax?

Busy Mind?

Can’t feel the here and now?

Reading on the john?



The new ORAL history…

Do you relax with mild stimulants?

- smoking (ammonia = smelling salts)

- caffeine (respiratory stimulant)- Ritalin/ cocaine

- fast driving?

- weaving in and out of traffic

All these OPEN AIRWAYS !



Is the patient choking?

SIGNS

holding breath

chest (not belly) breathing

receding jaw

“allergic shiners”

head tilt forward

poor posture

tachycardia

hypoxemia (pulse ox)

overbite (end stage)

SYMPTOMS

snoring

apnea

yawning/ sighing

bruxism

tornado sheets in AM

restless legs

motion sickness

Clearing throat

Nodding off when seated

J D



JAW DYSFUNCTIONS

EVALUATED:

Ease of Swallowing

Ease of Speaking

Ease of Breathing



Ease of Swallowing

Have a special way to swallow?

Use various head and jawpositions for swallowing?

Does food or pills get caught?Hair-trigger gag reflex?



Ease of Speaking

Words mixed up when tired or

not paying attention?Generally not crisp speech?

softly speaking?

Asked to repeat frequently?

Stuttering?



Ease of Breathing

Out of breath when sitting,

walking or climbing stairs?Sigh / yawns frequently?

Forgets to breathe?Shallow (chest vs. belly) breath?



Are YOU choking?

A. touch back teeth together lightly and pullchin in like you are saluting then check forresistance to breathing (watch chest)

- compare breathing with

B. drop and relax the jaw, thrust the jawforward so that the lower teeth are farther outthan the upper teeth (watch belly)



Compensatory

Conditions

Consequentto

Clenching !



Posture breakdown

Forward Head Posture

FibromyalgiaChronic Fatigue

Myriad Pains – neck, shoulder, hip, back







Stayin’ Alive…..

Forward Head Posture

Epinephrine Effects – Fast cars, motorcycles, sky diving, stimulant drugs,

nicotine, caffeine…

Jaw Muscle Activity – Bruxism, TMJ, Tongue out





“It’s not polite to stick your

tongue out!”

But it does get results…

Michael Jordan

Pete Sampras

Andre Watts

Brad Weeks

Dogs









http://users2.ev1.net/~binker/New/spicegeri5d.jpg








http://images.google.com/imgres?imgurl=www.sasked.gov.sk.ca/docs/chemistry/mission2mars/contents/chapter5/images/malamute.jpg&imgrefurl=http://www.sasked.gov.sk.ca/docs/chemistry/mission2mars/contents/chapter5/chap5_3.htm&h=360&w=240&sz=27&tbnid=eL2cONLInwMJ:&tbnh=116&tbnw=78&start=5&prev=/images%3Fq%3Ddog%2Btongue%26hl%3Den%26lr%3D%26ie%3DUTF-8%26oe%3DUTF-8



http://images.google.com/imgres?imgurl=www.sasked.gov.sk.ca/docs/chemistry/mission2mars/contents/chapter5/images/malamute.jpg&imgrefurl=http://www.sasked.gov.sk.ca/docs/chemistry/mission2mars/contents/chapter5/chap5_3.htm&h=360&w=240&sz=27&tbnid=eL2cONLInwMJ:&tbnh=116&tbnw=78&start=5&prev=/images%3Fq%3Ddog%2Btongue%26hl%3Den%26lr%3D%26ie%3DUTF-8%26oe%3DUTF-8





Parental Challenges

Tongue thrust -> buck teeth

- push tongue back in mouth with spoon

- suck on hard candy atop the hard palate

- braces

- retainers

- crowns (and later… dentures!)

Remember: the tongue forms the teeth and 48% of the sensory cortex can’t be all wrong

















ADHD

Elimination of dairy, wheat, corn, yeast,soy, citrus, egg, chocolate, peanuts,artificial colors, and preservatives) after just

two weeks, 73% of children responded

favorably as measured by the Conner Parent

Rating Scale. The Annals of Allergy, Vol. 72, May 1994
















MOA for Food Allergies

Brain Edema?

Increased heart rate ? (pulse test)

Choking? – Vascular tongue bathed in an allergen becomes

edematous and swells…. Nowhere to go but

back and down into the throat against thetrachea obstructing airway --> Agitation!
















Systemic Edema associated with

Headaches

PMS









St t f A it ti




States of Agitation

Schizophrenia

ManiaPanic Attacks

ADHDDepression

“ for some reason my patients











…for some reason my patients

who are viciously choking feel

and appear anxious.”

“If you found a drowning lady inthe lake would it surprise you if

she were thinking a lot about

death and dying.”

Dr. Farrand Robson














Unhappy Tongue and Airway

Can Disrupt and Impair the Nervous

System Coordination:

– Sensory Systems

– Autonomic Function

– Motor Output

– Sleep Architecture

O l S t i B l
















Oral Systemic Balance

Homeostasis

– The equilibrium maintained by complex

biological mechanisms via the autonomicnervous system to offset disrupting changes.

Oral Systemic Balance

– The equilibrium between the mouth and the

rest of the body via the autonomic nervous

system to offset disruptive changes.

O th l l B fit f

















Orthomolecular Benefits of

Opening the Airway

Increased oxygenation of blood

- less hospitable for cancer- restoration of optimal blood pH

Optimization of enzymatic activity

- less need for supplements Access to stage 3, 4 restorative and

regenerative SLEEP

If your patient is agitated

















If your patient is agitated,

1) remember your A, B, C’s.

2) Do an ORAL History

3) Check the airway

before you medicate orsupplement












The rest of your days begin(s) with the

rest of your nights.






Sleep Disorders

Insomnia

Excessive Daytime sleepiness

Cataplexy/Narcolepsy

Snoring

Sleep Apnea

– C-PAP and right sided heart damage

SLEEP DISTURBANCE AND

















SLEEP DISTURBANCE AND

NONMALIGNANT CHRONIC PAIN:A Comprehensive Review of The Literature

Sleep Disturbances In 50-70% of Pain

Patients The Most Common In

– Headache

– Chronic Pain

– Fibromyalgia – Rheumatic Diseases And Arthritis

Menefee, Pain Medicine. 2000;1























SNORING AND HEADACHE

260 Headache Days / Year In 206 Snorers

24 Headache Days / Year In 507 Others 24% In Headache Group Always Snore

14% In Non Headache Group Always Snore

Dr. Ann Sheer, National Institute on Aging

May 2003 Journal of Neurology

Why we need to treat






















Why we need to treat

Insomnia “Insomnia can become a form of contemplation.

You just lie there, inert, helpless, alone, in the

dark, and let yourself be crushed by the

inscrutable tyranny of time.”

Thomas Merton












My favorite Sleep Aid

“Heavenly Morpheus,

in vain do you wave the poppies;

My eye will remain awake,if Amor will not close it”.

Johann Wolfgang von Goethe

- Think abou tit…. (sic)

My Favorite Orthomolecular


















My Favorite Orthomolecular

Sleep Aid Xyrem (GHB) – “back on the market”

– Only endogenous agent available that consistently

allows patients to achieve stage 3, 4 deep restorative

and regenerative sleep;

– Not addictive

– Onset 15-45 minutes

– Duration 3-5 hours – No AM sedation/confusion

– Starting dose 4 grams (8 ml) - MRX1

– www.xyrem.info 1-866-XYREM-88

Sodium Oxybate:
























http://www.xyrem.info/

http://www.xyrem.info/



y

Development Milestones

Sodium oxybate discovered

Used in Europe for anesthesia(and ETOH detoxification)

1960s—

Clinical evaluation for narcolepsy1970s—

Two independent controlled studies1980s—

FDA approached Orphan Medicalto develop sodium oxybate1994—

Sodium oxybate received FDA approvalfor cataplexy

2002—



Sodium Oxybate

Pharmacokinetics of anorthomolecular but

prescription agent“Xyrem” aka GHB

Sodium Oxybate:



Pharmacokinetics Summary

Absorption Tmax = 0.5 h-1.25 h

Dose proportionality Nonlinear kinetics

Distribution <1% protein bound

Metabolism Bioavailability ~25%

(hepatic first-pass metabolism)

Diffuse cellular metabolism

End product CO2 + H2O

No active metabolite (no effect on cytochrome p450)

Elimination Predominantly metabolized

~5% unchanged in urine

T1/2 = 40-60 min (clears system fast and cleanly)

Food Slows bioavailability - take on empty stomach



Metabolism Rapid absorption, short half-life, once or twice-

nightly dosing

Nonlinear pharmacokinetics

– Doubling dose yields 3-4 × systemic levels; therefore,dosing titrated

Renal impairment: no effect expected

Hepatic impairment: suggest dose by 50%

Food slows bioavailability – Dose several hours after eating

No pharmacokinetic tolerance w/ chronic HS use

Sodium Oxybate: Physiology



Sodium Oxybate: Physiology

Endogenous metabolite of GABA

Neuromodulator of

– GABA

– Dopamine – Serotonin

– Endogenous opioids

Evidence for role as neurotransmitter – Synthesized in neurons, stored in vesicles, released via

depolarization into synaptic cleft, reuptake, specificreceptors

Sodium Oxybate: CNS



Sodium Oxybate: CNS

PharmacologyBinds to GABAB receptor

– May play important role in pharmacologic activity attherapeutic dosage levels

– Antagonism of GABAB in animal models inhibitssodium oxybate –induced sleep and someneuromodulation effects

Metabolic effects (think “hibernation”)

– Decreases cerebral glucose utilization (!!)

– Cerebral protective effects (!!)

Sodium Oxybate:DBPC Trial Efficacy in Cataplexy at



DBPC Trial Efficacy in Cataplexy atWeek 4

N=136 Start. N=120 End.

*P =0.0451 vs placebo; †P =0.0016 vs placebo.

US Xyrem Multicenter Study Group. Sleep . 2002;25:42.

Placebo

3 6 9

Sodium oxybate dose (g)

C

h a n g e f r o m b a s e l i n e

M

e d i a n ( 1 s t / 3 r d

q u a r t i l e )

a t t a c k s / w k

0

10

-10

-20

-30

-40

* †

Stimulant medications maintained.

Sodium Oxybate:



y

DBPC Trial Efficacy in EDSDaytime Sleepiness (Baseline to End Point: Medians)

6

810

12

14

16

18

20

22

24

P < 0.0001

Placebo

B E

3.0 g

B E

6.0 g

B E

9.0 g

B E

NarcolepsyRange

NormalRange E

p w o

r t h S l e e p i n e s

s S c a l e

( m e d i a n s 1 s t / 3 r d q u a r t i l e )

N=136 Start. N=120 End.

US Xyrem Multicenter Study Group. Sleep . 2002;25:42.

Stimulant medications maintained.

Sodium Oxybate:



Sodium Oxybate:

Efficacy Conclusions Consolidates nighttime sleep

– Stage 3 and 4 sleep

– Delta power

– Nighttime awakenings

No evidence of tolerance with long-term use

Improves physician overall impression of clinical status

Improves patient perception of quality of life

Sodium Oxybate: Safety



Sodium Oxybate: Safety

Associated adverse effects include:

Withdrawals from controlled trials due to SE

– 6% sodium oxybate vs. 1% placebo

No evidence of withdrawal syndrome at therapeutic doses

No rebound insomnia

Supportive/symptomatic treatment of overdose

No evidence of dose escalation/abuse (unless daytime dosages)

Not to be used with other sedatives

Sodium Oxybate:



Airway and Ventilatory Effects

Patients with obstructive sleep apnea (OSA)

– No specific study in OSA

– No decrease in oxygen saturation in 6 patients

with OSA studied

All patients

– No decrease in oxygen saturation

Ristanovic et al. Sleep. 2002;24(suppl):A473.

Black et al. Sleep. 2002;24(suppl):A474.





Principles of

IV TreatmentProtocols

“Test then Treat ”



“Test then Treat.”

-Red Blood Cell Essential Fatty Acids

-Plasma Amino Acids

-Elemental Minerals

No more need to guess!

Target deficiencies.Reduce toxicities.

Tailor-made vs. generic replacement.

It i f i t t k



It is far easier to take

measurementsthan it is to know

what it is we are

measuring.



Principles of IV Treatments

Primum non Nocere

- Increased risk of acute events with IV Rx

- Use heparin and B-vitamins all the time

Buffering osmolality and managing pH

Normal saline vs. sterile water vs. D-50Concentrations / dosages (cookbook)



Why IV Protocols?

Benefits

Acute intervention

Better absorption

– SAMe

– amino acids

– cationic mineralsEnhanced Compliance

Light at end of tunnel

Risks

More invasive

Embolism

Phlebitis

Rapid conversions

– tyrosine /phenylalanineconvert to dopamine-- a

potential problem.



M d Ch ll



Modern Challenges

-Difficult to do in an office setting

-Atypical anti-psychotics mask the illness

-Most psychotic patients DO flush with oralniacin (use thiosalasilic acid)

-Conclusion: many present as drug inducedpsychosis and not true schizophrenia;

M d Ch ll



Modern Challenges (cont.)

Medical Legal issues

– Competency – Guardianship

– Informed Consent vs. Request for Care

– Follow-up care (PO, IM protocols)

Li it ti f IV’



Limitations of IV’s

One IV treatment is not enough

Not always easy to achieve IV access

IM glutathione 100mg brain specificantioxidant

– 3 cc (hurts with muscle stretch) - less stress

IV glutathione

oxidation

- adrenochrome



IV Lipids



Supplementation with a combination of

-3 fatty acids and antioxidants

(vitamins E and C) improves the

outcome of schizophrenia.

Meena Arvindakshana, Madhav Ghateb, et al.

Schizophrenia Research

Volume 62, Issue 3 , 1 August 2003, p 195-204

S f IV Li id



Sources for IV Lipids

Essentiale N

- from Paracelsus Apoteke (Swiss)

Fax 011-41-55-418-4071

Liposyn III (50% safflower/soybean)

– From Apothecure (Texas) – Tel 800-969-6601

Ri k f IV Li id



Risks of IV Lipids

Embolism

Phlebitis

Th ti l R ti l



Theoretical Rationale:

The greater the atomic diameter of alkali metals, the longer they

persists in the NA-K channelsthereby stabilizing the efflux of sodium ions out of the cell

membrane.

C St d M i



Case Study: Mania



IV t l f M i



IV protocols for Mania

Magnesium and Vit B6

Glutathione

Lipids Cesium 1-2mg max at 10mg (slow push)

Side Effect: venous irritation



IV protocols for Anxiety



IV protocols for Anxiety

Meyer’s Cocktail

Magnesium and B 6 – slow push IV Vitamin C – an anti-histamine

Case Study: Anxiety



Case Study: Anxiety

Schizophrenia



Schizophrenia

Given Abram's theory of oxidative damage

by the adrenochrome the use of IV

antioxidants seems the most appropriate.

IV Protocols for Schizophrenia



IV Protocols for Schizophrenia

Reducing adrenaline

– Vitamin C

Methyl Donor

– Niacin 100mg/cc RX 1-10cc with thiosalicylates, Vit C andpantothenic acid B5

(Lysing the LSD - Hoffer personal correspondence)

– Thiotic acid

Support membrane stabilization – Fatty acids

Correcting Imbalances

– Per specific testing

Case Study:



y

Schizophrenia

Depression



Depression

Pesticide & chemical exposure

Fatty acid imbalances

Heavy metal toxicity Hormonal imbalances

Environmental and food

Yeast overgrowth

Amino acid imbalances

IV protocols for Depression



IV protocols for Depression

Essential amino acids: Freeamine,

Essential fatty acids: Liposyn III

Minerals: cesium, rubidium, magnesium etc.

B vitamins

– B 12, energy (shunts odd chained FA to Krebs cycle)

– B 6,

– B 3, supports serotonin synthesis

– B 5, adrenal support

Depression



Depression

SAMe injectable univials 200 and 400 mg.each. and must be reconstituted just beforeuse. it makes a huge sense to use it parently

because it is poorly absorbed by mouth.

just as reduced glutathione.

as opposed to lipoic acid which is very easy

absorbed by mouth. Thioctic and NAC easy too

Alkali metals listed



by molecular weight

PotassiumLithium

RubidiumCesium



Rubidium



Rubidium

Pharmacologic Role of Rubidium inPsychiatric Research

Robert Williams

Comprehensive Psychiatry 1987 13 (9)46-54

Alkali Metals A Comparison



Alkali Metals – A Comparison

RubidiumIncreases spontaneous motor activity

Increases EEG activity

Affects K+ mediated physiology

Antagonizes ETOH induced narcosis

Increases norepinepherine turnover

Catacholamine degradation primarily

via O’methylation pathway

Elicits anti-manic response

Depression-Potassium-Rubidium

LithiumDecreases spontaneous motor activity

Decreases EEG activity

Affects Na+ mediated physiology

Potentiates ETOH induced narcosis

Decreases norepinepherine turnover

Catacholamine degradation primarily

via deamination pathway

Elicits anti-manic response

Mania – Sodium- Lithium

Case Study: Depression



Case Study: Depression

Depression



Depression

FreeAmineIn 500mg nl saline

Lithium chloride 1-2mg

(note: low Li in NW soil)Rubidium 1-10mg

CalciumTrace Minerals

B vitamins

H rin ni

Summary



y

Dr. Hugh Reardon – genes – trickle up

Dr. Rollo May - spirit - trickle down

We have considered ORTHO as applies to

all aspects of the patient and remembered

fundamentals to be applied while givingorthomolecular supplements.

REMEMBER



REMEMBER

A, B, C’s

Airway,

Breathing &

…….Cleep



Paracelsus Oath:

This is my Vow:



This is my Vow:

To perfect my medical art and never to

swerve from it so long as God grants me my office,

and to oppose all false medicines and teachings.

Then to love the sick, each and all of them, more

than if my own body were at stake. Not to judgesuperficially, but by symptoms, nor to administer

any medicine without understanding, nor to

collect any money without earning it. Not to trust

any apothecary, nor to do any violence to anychild. Not to guess, but to know.

Paracelsus 1493 - 1541

Polling Our Peers



Polling Our Peers

Saul Pilar, M.D.

High doses of glutathione

moderate doses of l-methionine (not dl-methionine !!! )

glycine

glutamine

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Towards an Understanding and Practice of Intravenous Orthomolecular Treatments for Mental Illnesses

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