Transparent MXene MicroECoG Electrodes for Multi-Modal Seizure Monitoring
Gari EberlyPhD students: Nicki Driscoll and Brendan Murphy
PI: Dr. Flavia VitaleCenter for Neuroengineering and Therapeutics
Epilepsy“Disorder of the brain characterized by the predisposition to
generate epileptic seizures”
[1] Epileptic seizures and epilepsy… Epilepsia, 46(4), 470-472.
Need to develop more effective treatments for epilepsy
Need to develop more effective treatments for epilepsy
Development requires characterization of behavior and pathway of seizure
Need to develop more effective treatments for epilepsy
Development requires characterization of behavior and pathway of seizure
Must monitor seizure on micron level with high temporal and spatial resolution
Develop a micro-electrocorticographic device capable of multi-modal seizure monitoring
Two-Photon Imaging
Electrophysiological Recording
Develop a micro-electrocorticographic device capable of multi-modal seizure monitoring
[2] Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging. Nature communications, 5, 5259.
Develop a micro-electrocorticographic device capable of multi-modal seizure monitoring
[3] Epidural and foramen-ovale electrodes in the diagnostic evaluation of patients considered for epilepsy surgery. Epileptic disorders : international epilepsy journal with videotape. 12. 48-53.
MXene (Ti3C2Tx)
✓Sheet resistance(47 Ω/sq at 62 nm)
✓Volumetric Capacitance(676 F cm−3)
✓Conductivity(10,000 S/m)
✓Biocompatible✓Flexible✓Hydrophilic
[4] High-Capacitance Mechanism for Ti3C2Tx MXene by in Situ Electrochemical RamanSpectroscopy Investigation. ACS nano, 10 12, 11344-11350 .
Fabrication and CharacterizationUse MXene to create transparent Micro-ECoG electrodes
Optimize spray coating procedure
Characterize MXene electrodes using electrochemical impedance spectroscopy and UV-Vis spectroscopy
1 2
Si Parylene-C Gold MXene SiO2 Al
2 3
Si Parylene-C Gold MXene SiO2 Al
3 4
Si Parylene-C Gold MXene SiO2 Al
4 5
Si Parylene-C Gold MXene SiO2 Al
5 6
Si Parylene-C Gold MXene SiO2 Al
6 7
Si Parylene-C Gold MXene SiO2 Al
8
Final8
Gold Pads
MXene Traces
Parylene-C Encapsulation
1.5 mm
Device CharacterizationObserved optical transparency and film quality
UV-Vis Spectroscopy - more precisely characterize transparency of Ti3C2Tx films at wavelengths ranging from 340-1000 nm
Electrochemical impedance spectroscopy (EIS) - characterize impedanceof the Ti3C2Tx electrodes.
Bright Field Microscopy
Graphene 10 - MXene 5 - MXene 15 - MXene
UV –Vis Spectroscopy
Transmittance at 550 nm:
5 Sprays: 74 ± 1%
10 Sprays: 68.2 ± .8%
15 Sprays: 44.2 ± .5%
Common λ - Two-Photon Imaging
EIS
Impedance at 1 kHz:
5 Sprays: 280 ± 73 kΩ
10 Sprays: 46 ± 14 kΩ
15 Sprays: 5 ± 1 kΩ
Graphene: 2110 ± 98 kΩ
Graphene 10 - MXene
5 - MXene 15 - MXene
Thank you!!REU Students: Tessa Posey, Nancy Rodriguez Mentors: Nicki Driscoll, Brendan Murphy, Dr. Nick ApolloPIs: Dr. Flavia Vitale and Dr. Brian LittCNT: Carolyn Wilkinson, Everett PrinceSingh REU: Kristin Field, Eric Johnson
Transparent MXene MicroECoG Electrodes for Multi-Modal Seizure Monitoring
Gari EberlyPhD students: Nicki Driscoll and Brendan Murphy
PI: Dr. Flavia VitaleCenter for Neuroengineering and Therapeutics
