Ultrasound Elastography: Prostate Cancer Detection

Assessment Using A Phantom

Brett CoelhoMedical Biophysics 3970Z

March 26, 2013

Introduction

Prevalence and Early Detection Ultrasound Elastography Specificity and Sensitivity

B-mode Prostate Image

Introduction Stiffness Strain Images

B- mode Image Strain Image

Methods Hooke’s Law

Young’s Modulus Reconstruction: Iterative

Methods

Phantom Construction

Phantom Ingredients

Methods

Preparing Phantom Solutions Gelatin – 70 Agar – 80 Formaldehyde – 90 Glycerol – 90 Sigma Cell Cool Down

Methods Pouring The Moulds

Prostate and Surrounding Tissue Moulds Tumor Moulds

Methods Pouring The Moulds

Prostate and Sample Moulds

Methods

Uniaxial Test

Uniaxial Testing Machine and Cylindrical Sample

Methods Ultrasound

Circular Ultrasound Array

Linear Array

Methods

Strain Images

Strain Imaging

Results Uniaxial Results Ratios Ep/Es=5.4 Et1/Es=8.7 Et2/Es = 9.3

Strain

Stress kPa

Results Post Processing Elastic Moduli Reconstruction

Strain Image Frames

Results Post Processing Ep/Es=2.2 Et1/Es=6.0 Et2/Es=8.9

Phantom Tissue Manual Selections

Results Tumour Mis Allocations TM1=5.21 TM2=5.68

Reconstructed Image Tumor Locating B-mode Image Tumor Locating

Conclusions

Comparing the ratios Tumor Misallocations

Sources of Error

Strain Images

Uniaxial Test

Assumptions for Stress Calculation

Future Research

Improve Detection and Modulus Calculations

Computational Time

Assumptions and Meshing

Acknowledgements

Dr. Samani

Reza Mousavi

Thank you!