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Understanding Cancer and Related Topics

Understanding Nanodevices

Developed by:Jennifer Michalowski, M.S.Donna Kerrigan, M.S.Jeanne KellyBrian HollenExplains nanotechnology and its potential to improve cancer detection, diagnosis, and treatment. Illustrates several nanotechnology tools in development, including nanopores, quantum dots, and dendrimers.

These PowerPoint slides are not locked files. You can mix and match slides from different tutorials as you prepare your own lectures. In the Notes section, you will find explanations of the graphics. The art in this tutorial is copyrighted and may not be reused for commercial gain.Please do not remove the NCI logo or the copyright mark from any slide. These tutorials may be copied only if they are distributed free of charge for educational purposes.

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What Is NanoBiotechnology?

NanodevicesNanoporesDendrimersNanotubesQuantum dotsNanoshells

Tennis ballA periodWhite blood cell

Water molecule

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Designing Nanodevices for Use in the Body

Too BigToo Small

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Manufacturing Nanodevices

Scattered X-rays

Atoms in crystal

Detector

NanodevicesCrystal White blood cell

CrystalX-ray beam

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Nanodevices Are Small Enough to Enter Cells

Cell

White blood cell

Water molecule

Nanodevices

Nanodevices

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Nanodevices Can Improve Cancer Detection and Diagnosis

ImagingNanoBiotechnology Physical Exam,Symptoms

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Nanodevices Can Improve Sensitivity

and determinewhich cells arecancerous orprecancerous.

Precancerous cells

Normal cells

Nanodevices could potentiallyenter cells

Precancerous cells

Normal cells

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Nanodevices Can Preserve Patients’ Samples

Cells from patientCells preserved

Active state preserved

Cells altered Active state lost

Additional tests

Cells from patient

Nanotechnology Tests

Traditional Tests

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Nanodevices Can Make Cancer TestsFaster and More Efficient

Patient A Patient B

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Cantilevers Can Make Cancer TestsFaster and More Efficient

Cancer cell

Watermolecule

NanodevicesCantilevers

Antibodieswith proteins

Antibodies

Whiteblood cell

Bent cantilever

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Nanopores

ASingle-strandedDNA molecule

Single-strandedDNA molecule

Whiteblood cell

Watermolecule

NanodevicesNanopores

Single-strandedDNA molecule

ATCGNanopore Nanopore

Nanopore

T

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Quantum DotsUltraviolet

light off

Whiteblood cell

Watermolecule

NanodevicesQuantum dots

Quantum dots emit light

Ultravioletlight on

Quantumdots

Quantum dotbead

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Quantum Dots Can Find Cancer Signatures

Cancer cells

Healthy cells

Quantum dot beads

Quantum dot beads

Healthy cells

Cancer cells

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Improving Cancer TreatmentNanotechnology TreatmentTraditional Treatment

Intact noncancerous cells

Noncancerous cells

Toxins Nanodevices

Cancercells

Dead noncancerous cells

Noncancerous cells

Drugs

Deadcancercells

Deadcancercells

ToxinsCancercells

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Nanoshells

Nanoshell

Whiteblood cell

Watermolecule

Nanodevices Nanoshells

Gold

Near-infrared light onNear-infrared light off

Nanoshell absorbs heat

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Nanoshells as Cancer TherapyNanoshells

Dead cancer cells

Nanoshells

Cancer cells

Healthy cells

Intact healthy cells

Near-infrared light

Healthy cells

Cancer cells

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Nanodevices as a Link BetweenDetection, Diagnosis, and Treatment

Nanodevice

Reporting

TargetingDetection

Imaging

NanoBiotechnologyCancer Treatment

Cancer cell

TraditionalCancer Treatment

Cancer cell

Drug

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Dendrimers

Dendrimer

Whiteblood cell

Watermolecule

Nanodevices Dendrimer

Cancer cell

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Dendrimers : Highly Branched Dendritic Macromolecules

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● Characteristics Monodisperse macromolecule Globular (Spherical) Facile surface bio-functionalization Similar molecular size to biomolecules (Glucose oxidase 65.27.7 nm)

Molecular carriers for chemical catalysts(Core, Peripheral)

Medical applications (MRI contrast enhancer)

Biomimetic catalysts(Peptides-, Glycodendrimers)

Vehicles for delivery of genes and drugs

Poly (amido amine) Dendrimers

4.5 nm

G4 Poly(amidoamine) Dendrimer

● Applications

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Dendrimers as Cancer Therapy

Cell deathmonitor

Reporter

Therapeuticagent

Cancerdetector

Watermolecule

Whiteblood cell

Nanodevices Dendrimer

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NanoBiotechnologies in Patient Care

Today 2020

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We would like to hear from you . . .

If you have questions about this tutorial’s content, suggestions for new topics, or other feedback on the Web site, please send an e-mail to kerrigad@mail.nih.gov.

If you have questions about this tutorial’s artwork or want permission to use it, please send an e-mail to beankelly@verizon.net.