560 T

" XBD=321 XHG=113 YBD=237 YHG=202>Paleozoic " XBD=414 XHG=346 YBD=236 YHG=213>sea " XBD=554 XHG=437 YBD=237 YHG=201>when " XBD=649 XHG=577 YBD=239 YHG=202>the " XBD=920 XHG=672 YBD=236 YHG=201>vertebrates " XBD=1017 XHG=944 YBD=236 YHG=201>left " XBD=1075 XHG=1041 YBD=236 YHG=202>it " XBD=1182 XHG=1100 YBD=236 YHG=202>and " XBD=1311 XHG=1206 YBD=237 YHG=201>their" XBD=238 XHG=116 YBD=286 YHG=250>blood " XBD=442 XHG=264 YBD=293 YHG=251>became, " XBD=514 XHG=470 YBD=286 YHG=251>in " XBD=564 XHG=540 YBD=287 YHG=263>a " XBD=952 XHG=591 YBD=298 YHG=250>physicochemical " XBD=1105 XHG=980 YBD=292 YHG=262>sense, " XBD=1231 XHG=1134 YBD=285 YHG=251>shut " XBD=1317 XHG=1258 YBD=286 YHG=250>off" XBD=220 XHG=115 YBD=334 YHG=299>from " XBD=283 XHG=237 YBD=335 YHG=300>it. " XBD=526 XHG=337 YBD=335 YHG=299>Brilliant " XBD=626 XHG=544 YBD=335 YHG=300>and " XBD=895 XHG=643 YBD=344 YHG=299>stimulating " XBD=957 XHG=913 YBD=334 YHG=311>as " XBD=1007 XHG=973 YBD=334 YHG=300>it " XBD=1071 XHG=1024 YBD=342 YHG=301>is, " XBD=1152 XHG=1089 YBD=334 YHG=299>his " XBD=1314 XHG=1168 YBD=345 YHG=300>theory" XBD=189 XHG=115 YBD=385 YHG=349>has " XBD=288 XHG=213 YBD=383 YHG=352>not " XBD=416 XHG=313 YBD=384 YHG=350>been " XBD=634 XHG=441 YBD=395 YHG=348>accepted " XBD=715 XHG=658 YBD=393 YHG=348>by " XBD=866 XHG=739 YBD=382 YHG=348>either biologists " XBD=1199 XHG=1114 YBD=383 YHG=351>2 or " XBD=1312 XHG=1224 YBD=394 YHG=359>geo-" XBD=336 XHG=118 YBD=433 YHG=398>chemists.a " XBD=441 XHG=389 YBD=432 YHG=398>In " XBD=528 XHG=457 YBD=433 YHG=399>the " XBD=633 XHG=545 YBD=431 YHG=397>first " XBD=777 XHG=650 YBD=442 YHG=396>place, " XBD=899 XHG=797 YBD=431 YHG=408>even " XBD=988 XHG=916 YBD=432 YHG=397>the " XBD=1254 XHG=1006 YBD=442 YHG=396>body-fluids " XBD=1318 XHG=1273 YBD=432 YHG=396>of" XBD=186 XHG=116 YBD=482 YHG=446>the " XBD=416 XHG=222 YBD=492 YHG=447>majority " XBD=497 XHG=452 YBD=481 YHG=447>of " XBD=680 XHG=528 YBD=480 YHG=446>marine " XBD=1008 XHG=715 YBD=481 YHG=445>invertebrates " XBD=1112 XHG=1045 YBD=481 YHG=458>are " XBD=1238 XHG=1163 YBD=481 YHG=449>not " XBD=1316 XHG=1272 YBD=480 YHG=446>in" XBD=278 XHG=117 YBD=541 YHG=496>passive " XBD=546 XHG=290 YBD=541 YHG=495>equilibrium " XBD=656 XHG=557 YBD=528 YHG=494>with " XBD=998 XHG=670 YBD=530 YHG=495>sea-water-the " XBD=1316 XHG=1012 YBD=530 YHG=495>concentration" XBD=252 XHG=122 YBD=580 YHG=544>ofH+ " XBD=361 XHG=279 YBD=579 YHG=545>and " XBD=449 XHG=382 YBD=578 YHG=543>K+ " XBD=510 XHG=475 YBD=577 YHG=543>is " XBD=667 XHG=527 YBD=587 YHG=542>higher " XBD=791 XHG=688 YBD=578 YHG=544>than " XBD=855 XHG=812 YBD=578 YHG=544>in " XBD=943 XHG=872 YBD=578 YHG=544>the " XBD=1041 XHG=962 YBD=584 YHG=555>sea, " XBD=1143 XHG=1062 YBD=578 YHG=544>and " XBD=1254 XHG=1160 YBD=578 YHG=544>that " XBD=1319 XHG=1273 YBD=578 YHG=543>of" XBD=240 XHG=119 YBD=639 YHG=593>Mg++ " XBD=497 XHG=263 YBD=637 YHG=591>and S04-- " XBD=654 XHG=523 YBD=626 YHG=591>lower. " XBD=799 XHG=710 YBD=627 YHG=591>Still " XBD=897 XHG=820 YBD=627 YHG=592>less " XBD=948 XHG=914 YBD=627 YHG=593>is " XBD=999 XHG=965 YBD=627 YHG=593>it " XBD=1106 XHG=1016 YBD=627 YHG=595>true " XBD=1170 XHG=1125 YBD=626 YHG=591>of " XBD=1312 XHG=1184 YBD=627 YHG=595>verte-" XBD=377 XHG=120 YBD=677 YHG=641>brates-the " XBD=641 XHG=394 YBD=675 YHG=640>fresh-water " XBD=798 XHG=655 YBD=675 YHG=640>teleost " XBD=889 XHG=815 YBD=676 YHG=642>has " XBD=947 XHG=903 YBD=676 YHG=645>to " XBD=1071 XHG=961 YBD=676 YHG=642>work " XBD=1129 XHG=1084 YBD=676 YHG=644>to " XBD=1314 XHG=1144 YBD=686 YHG=644>prevent" XBD=232 XHG=120 YBD=725 YHG=690>itself " XBD=429 XHG=254 YBD=735 YHG=689>swelling " XBD=511 XHG=454 YBD=735 YHG=701>up " XBD=628 XHG=546 YBD=724 YHG=690>and " XBD=848 XHG=653 YBD=735 YHG=689>bursting, " XBD=946 XHG=876 YBD=724 YHG=690>the " XBD=1133 XHG=980 YBD=724 YHG=690>marine " XBD=1314 XHG=1168 YBD=726 YHG=690>teleost" XBD=166 XHG=120 YBD=773 YHG=742>to " XBD=354 XHG=184 YBD=784 YHG=741>prevent " XBD=484 XHG=372 YBD=773 YHG=737>itself " XBD=618 XHG=500 YBD=784 YHG=737>being " XBD=875 XHG=637 YBD=774 YHG=738>desiccated. " XBD=1045 XHG=928 YBD=779 YHG=739>True, " XBD=1135 XHG=1065 YBD=772 YHG=738>the " XBD=1312 XHG=1156 YBD=773 YHG=738>cartila-" XBD=264 XHG=122 YBD=833 YHG=788>ginous " XBD=362 XHG=286 YBD=822 YHG=787>fish " XBD=491 XHG=385 YBD=822 YHG=787>have " XBD=654 XHG=513 YBD=823 YHG=788>bloods " XBD=845 XHG=676 YBD=823 YHG=788>isotonic " XBD=967 XHG=868 YBD=822 YHG=787>with " XBD=1212 XHG=991 YBD=829 YHG=790>sea-water, " XBD=1314 XHG=1237 YBD=822 YHG=788>but" XBD=192 XHG=122 YBD=872 YHG=836>the " XBD=379 XHG=224 YBD=883 YHG=840>greater " XBD=505 XHG=411 YBD=884 YHG=840>part " XBD=581 XHG=536 YBD=872 YHG=837>of " XBD=715 XHG=609 YBD=872 YHG=838>their " XBD=915 XHG=749 YBD=872 YHG=837>osmotic " XBD=1047 XHG=948 YBD=871 YHG=836>debt " XBD=1111 XHG=1078 YBD=870 YHG=837>is " XBD=1240 XHG=1143 YBD=882 YHG=836>paid " XBD=1315 XHG=1271 YBD=871 YHG=837>in" XBD=284 XHG=124 YBD=932 YHG=887>organic " XBD=662 XHG=311 YBD=933 YHG=898>currency-urea. " XBD=841 XHG=716 YBD=922 YHG=887>There " XBD=900 XHG=866 YBD=920 YHG=886>is " XBD=978 XHG=924 YBD=921 YHG=897>no " XBD=1194 XHG=1005 YBD=920 YHG=886>evidence " XBD=1314 XHG=1220 YBD=920 YHG=886>that" XBD=194 XHG=124 YBD=970 YHG=936>the " XBD=341 XHG=218 YBD=971 YHG=935>blood " XBD=410 XHG=365 YBD=971 YHG=936>of " XBD=679 XHG=430 YBD=971 YHG=937>vertebrates " XBD=784 XHG=702 YBD=971 YHG=948>was " XBD=900 XHG=808 YBD=970 YHG=947>ever " XBD=966 XHG=923 YBD=969 YHG=937>in " XBD=1149 XHG=989 YBD=980 YHG=935>passive " XBD=1311 XHG=1173 YBD=980 YHG=935>equili-" XBD=258 XHG=126 YBD=1020 YHG=985>brium " XBD=386 XHG=286 YBD=1020 YHG=985>with " XBD=634 XHG=415 YBD=1021 YHG=989>sea-water. " XBD=816 XHG=688 YBD=1020 YHG=986>Given " XBD=869 XHG=845 YBD=1020 YHG=997>a " XBD=1075 XHG=897 YBD=1029 YHG=984>working " XBD=1313 XHG=1103 YBD=1029 YHG=987>excretory" XBD=371 XHG=124 YBD=1069 YHG=1035>mechanism " XBD=618 XHG=387 YBD=1080 YHG=1034>constantly " XBD=833 XHG=632 YBD=1080 YHG=1034>depleting " XBD=917 XHG=848 YBD=1068 YHG=1034>the " XBD=1105 XHG=932 YBD=1068 YHG=1033>internal " XBD=1310 XHG=1120 YBD=1075 YHG=1034>medium,

PANTRN " XBD=505 XHG=306 YBD=1118 YHG=1083>2 believes " XBD=612 XHG=519 YBD=1119 YHG=1084>that " XBD=695 XHG=625 YBD=1118 YHG=1084>the " XBD=894 XHG=709 YBD=1119 YHG=1084>essential " XBD=1118 XHG=908 YBD=1118 YHG=1083>difference " XBD=1314 XHG=1131 YBD=1118 YHG=1084>between" XBD=194 XHG=124 YBD=1166 YHG=1133>the " XBD=330 XHG=225 YBD=1167 YHG=1133>ionic " XBD=615 XHG=361 YBD=1178 YHG=1133>proportions " XBD=692 XHG=648 YBD=1167 YHG=1133>of " XBD=841 XHG=720 YBD=1168 YHG=1133>blood " XBD=953 XHG=873 YBD=1167 YHG=1133>and " XBD=1193 XHG=986 YBD=1168 YHG=1136>sea-water " XBD=1312 XHG=1228 YBD=1176 YHG=1133>(the" XBD=334 XHG=125 YBD=1226 YHG=1180>relatively " XBD=441 XHG=344 YBD=1228 YHG=1181>high " XBD=517 XHG=451 YBD=1216 YHG=1182>K+ " XBD=617 XHG=536 YBD=1216 YHG=1182>and " XBD=707 XHG=630 YBD=1217 YHG=1182>low " XBD=862 XHG=722 YBD=1228 YHG=1181>Mg+ +) " XBD=954 XHG=879 YBD=1216 YHG=1194>can " XBD=1017 XHG=967 YBD=1217 YHG=1182>be " XBD=1243 XHG=1030 YBD=1228 YHG=1182>explained " XBD=1314 XHG=1258 YBD=1227 YHG=1182>by" XBD=196 XHG=125 YBD=1265 YHG=1231>the " XBD=452 XHG=220 YBD=1266 YHG=1230>differences " XBD=518 XHG=474 YBD=1266 YHG=1231>in " XBD=610 XHG=540 YBD=1266 YHG=1232>the " XBD=848 XHG=633 YBD=1266 YHG=1231>mobilities " XBD=916 XHG=872 YBD=1266 YHG=1231>of " XBD=1005 XHG=935 YBD=1266 YHG=1232>the " XBD=1116 XHG=1028 YBD=1267 YHG=1232>ions " XBD=1222 XHG=1140 YBD=1266 YHG=1231>and " XBD=1315 XHG=1244 YBD=1267 YHG=1232>the" XBD=213 XHG=125 YBD=1315 YHG=1283>rate " XBD=290 XHG=245 YBD=1315 YHG=1283>at " XBD=456 XHG=325 YBD=1315 YHG=1280>which " XBD=593 XHG=493 YBD=1327 YHG=1281>they " XBD=826 XHG=629 YBD=1316 YHG=1280>therefore " XBD=956 XHG=864 YBD=1327 YHG=1293>pass " XBD=1126 XHG=995 YBD=1317 YHG=1293>across " XBD=1352 XHG=1153 YBD=1322 YHG=1280>natural" XBD=379 XHG=126 YBD=1365 YHG=1330>membranes " XBD=511 XHG=405 YBD=1365 YHG=1330>from " XBD=611 XHG=540 YBD=1366 YHG=1331>the " XBD=808 XHG=639 YBD=1366 YHG=1330>outside. " XBD=988 XHG=862 YBD=1366 YHG=1331>These " XBD=1246 XHG=1016 YBD=1367 YHG=1332>differences " XBD=1317 XHG=1273 YBD=1366 YHG=1332>in

" XBD=315 XHG=127 YBD=1425 YHG=1379>mobility " XBD=416 XHG=335 YBD=1414 YHG=1379>will " XBD=489 XHG=438 YBD=1415 YHG=1380>be |>" XBD=775 XHG=510 YBD=1433 YHG=1381>exaggerated " XBD=852 XHG=794 YBD=1425 YHG=1381>by " XBD=942 XHG=871 YBD=1415 YHG=1381>the " XBD=1149 XHG=963 YBD=1426 YHG=1382>negative " XBD=1316 XHG=1173 YBD=1426 YHG=1381>charge" XBD=280 XHG=129 YBD=1464 YHG=1429>carried " XBD=356 XHG=299 YBD=1474 YHG=1429>by " XBD=482 XHG=374 YBD=1464 YHG=1432>most " XBD=663 XHG=502 YBD=1464 YHG=1430>natural " XBD=959 XHG=682 YBD=1464 YHG=1430>membranes.9" XBD=263 XHG=178 YBD=1514 YHG=1478>The " XBD=558 XHG=292 YBD=1525 YHG=1479>geochemical " XBD=774 XHG=586 YBD=1514 YHG=1479>evidence " XBD=835 XHG=800 YBD=1513 YHG=1479>is " XBD=915 XHG=862 YBD=1514 YHG=1491>no " XBD=1051 XHG=942 YBD=1514 YHG=1491>more " XBD=1316 XHG=1078 YBD=1524 YHG=1479>reassuring." XBD=212 XHG=128 YBD=1564 YHG=1528>The " XBD=415 XHG=228 YBD=1564 YHG=1528>essential " XBD=584 XHG=429 YBD=1564 YHG=1528>feature " XBD=646 XHG=601 YBD=1563 YHG=1528>of " XBD=941 XHG=662 YBD=1563 YHG=1528>McCALMJM’s " XBD=1103 XHG=957 YBD=1575 YHG=1529>theory " XBD=1150 XHG=1117 YBD=1564 YHG=1529>is " XBD=1260 XHG=1166 YBD=1564 YHG=1529>that " XBD=1320 XHG=1276 YBD=1563 YHG=1529>in" XBD=375 XHG=132 YBD=1614 YHG=1577>Ordovician " XBD=512 XHG=392 YBD=1613 YHG=1578>times " XBD=575 XHG=532 YBD=1613 YHG=1590>or " XBD=853 XHG=593 YBD=1613 YHG=1578>thereabouts " XBD=942 XHG=872 YBD=1613 YHG=1578>the " XBD=1029 XHG=962 YBD=1613 YHG=1590>sea " XBD=1131 XHG=1047 YBD=1613 YHG=1578>had " XBD=1220 XHG=1150 YBD=1613 YHG=1579>the " XBD=1319 XHG=1240 YBD=1613 YHG=1578>salt" XBD=433 XHG=131 YBD=1664 YHG=1627>concentration " XBD=502 XHG=457 YBD=1662 YHG=1627>of " XBD=784 XHG=524 YBD=1674 YHG=1628>present-day " XBD=1083 XHG=806 YBD=1666 YHG=1627>mammalian blood " XBD=1320 XHG=1238 YBD=1663 YHG=1628>and" XBD=224 XHG=130 YBD=1713 YHG=1678>that " XBD=275 XHG=241 YBD=1713 YHG=1677>it " XBD=366 XHG=292 YBD=1713 YHG=1678>has " XBD=487 XHG=384 YBD=1712 YHG=1678>been " XBD=660 XHG=505 YBD=1723 YHG=1678>getting " XBD=858 XHG=686 YBD=1723 YHG=1677>steadily " XBD=992 XHG=872 YBD=1712 YHG=1677>salter " XBD=1123 XHG=1011 YBD=1712 YHG=1678>since’ " XBD=1223 XHG=1138 YBD=1722 YHG=1677>(the " XBD=1321 XHG=1242 YBD=1712 YHG=1676>salt" XBD=251 XHG=131 YBD=1773 YHG=1727>being " XBD=314 XHG=269 YBD=1762 YHG=1727>of " XBD=509 XHG=327 YBD=1762 YHG=1726>volcanic " XBD=667 XHG=528 YBD=1773 YHG=1727>origin, " XBD=731 XHG=687 YBD=1762 YHG=1739>or " XBD=868 XHG=749 YBD=1772 YHG=1727>being " XBD=1039 XHG=888 YBD=1762 YHG=1727>carried " XBD=1144 XHG=1056 YBD=1762 YHG=1728>into " XBD=1233 XHG=1162 YBD=1762 YHG=1727>the " XBD=1320 XHG=1253 YBD=1762 YHG=1738>sea" XBD=188 XHG=131 YBD=1823 YHG=1777>by " XBD=282 XHG=211 YBD=1812 YHG=1777>the " XBD=430 XHG=305 YBD=1812 YHG=1778>rivers " XBD=499 XHG=455 YBD=1811 YHG=1788>as " XBD=548 XHG=524 YBD=1811 YHG=1789>a " XBD=697 XHG=571 YBD=1812 YHG=1776>result " XBD=766 XHG=721 YBD=1811 YHG=1776>of " XBD=885 XHG=788 YBD=1812 YHG=1777>rock " XBD=1092 XHG=909 YBD=1821 YHG=1777>erosion). " XBD=1199 XHG=1147 YBD=1811 YHG=1777>In " XBD=1320 XHG=1221 YBD=1818 YHG=1776>fact," XBD=327 XHG=131 YBD=1868 YHG=1827>however, " XBD=472 XHG=363 YBD=1871 YHG=1826>large " XBD=585 XHG=507 YBD=1860 YHG=1825>salt " XBD=796 XHG=620 YBD=1871 YHG=1826>deposits " XBD=899 XHG=832 YBD=1860 YHG=1837>are " XBD=1080 XHG=931 YBD=1861 YHG=1826>known " XBD=1157 XHG=1114 YBD=1861 YHG=1827>in " XBD=1322 XHG=1191 YBD=1861 YHG=1829>strata" XBD=272 XHG=131 YBD=1922 YHG=1876>dating " XBD=406 XHG=299 YBD=1910 YHG=1876>from " XBD=660 XHG=433 YBD=1916 YHG=1875>Cambrian, " XBD=1005 XHG=690 YBD=1910 YHG=1875>Permian-Trias " XBD=1116 XHG=1033 YBD=1910 YHG=1876>and " XBD=1323 XHG=1142 YBD=1911 YHG=1876>Miocene" XBD=263 XHG=131 YBD=1968 YHG=1926>times, " XBD=368 XHG=287 YBD=1960 YHG=1926>and " XBD=504 XHG=389 YBD=1960 YHG=1925>there " XBD=557 XHG=524 YBD=1959 YHG=1925>is " XBD=748 XHG=579 YBD=1971 YHG=1925>nothing " XBD=815 XHG=770 YBD=1960 YHG=1928>to " XBD=998 XHG=839 YBD=1971 YHG=1928>suggest " XBD=1112 XHG=1019 YBD=1960 YHG=1925>that " XBD=1234 XHG=1133 YBD=1971 YHG=1926>they " XBD=1322 XHG=1255 YBD=1960 YHG=1929>are" XBD=201 XHG=130 YBD=2010 YHG=1975>the " XBD=409 XHG=215 YBD=2022 YHG=1976>products " XBD=472 XHG=428 YBD=2010 YHG=1974>of " XBD=553 XHG=482 YBD=2010 YHG=1975>the " XBD=712 XHG=569 YBD=2020 YHG=1975>drying " XBD=781 XHG=726 YBD=2021 YHG=1986>up " XBD=841 XHG=797 YBD=2009 YHG=1974>of " XBD=1037 XHG=853 YBD=2010 YHG=1975>different " XBD=1169 XHG=1051 YBD=2021 YHG=1979>types " XBD=1230 XHG=1185 YBD=2010 YHG=1975>of " XBD=1321 XHG=1242 YBD=2010 YHG=1987>sea.|>" XBD=349 XHG=132 YBD=2061 YHG=2025>CONWAY has " XBD=557 XHG=453 YBD=2060 YHG=2025>tried " XBD=613 XHG=568 YBD=2060 YHG=2028>to " XBD=818 XHG=626 YBD=2060 YHG=2024>calculate " XBD=906 XHG=836 YBD=2060 YHG=2025>the " XBD=1003 XHG=924 YBD=2061 YHG=2025>salt " XBD=1324 XHG=1022 YBD=2060 YHG=2025>concentration" XBD=181 XHG=135 YBD=2111 YHG=2075>of " XBD=274 XHG=202 YBD=2110 YHG=2076>the " XBD=501 XHG=294 YBD=2110 YHG=2075>Paleozoic " XBD=587 XHG=520 YBD=2110 YHG=2087>sea " XBD=662 XHG=609 YBD=2109 YHG=2086>on " XBD=754 XHG=684 YBD=2109 YHG=2075>the " XBD=951 XHG=776 YBD=2121 YHG=2075>grounds " XBD=1017 XHG=973 YBD=2110 YHG=2074>of " XBD=1123 XHG=1041 YBD=2110 YHG=2079>two " XBD=1324 XHG=1145 YBD=2110 YHG=2078>extreme" XBD=403 XHG=132 YBD=2171 YHG=2125>hypotheses : " XBD=496 XHG=442 YBD=2169 YHG=2125>(a) " XBD=706 XHG=519 YBD=2159 YHG=2127>constant " XBD=1027 XHG=726 YBD=2159 YHG=2124>ocean-volume " XBD=1129 XHG=1047 YBD=2159 YHG=2125>and " XBD=1324 XHG=1149 YBD=2159 YHG=2124>chloride" XBD=326 XHG=135 YBD=2216 YHG=2178>content; " XBD=417 XHG=365 YBD=2218 YHG=2174>(b) " XBD=628 XHG=440 YBD=2209 YHG=2176>constant " XBD=949 XHG=648 YBD=2209 YHG=2173>ocean-volume " XBD=1068 XHG=969 YBD=2208 YHG=2174>with " XBD=1262 XHG=1088 YBD=2209 YHG=2173>chloride " XBD=1329 XHG=1283 YBD=2209 YHG=2173>of" XBD=315 XHG=133 YBD=2259 YHG=2223>volcanic " XBD=488 XHG=349 YBD=2269 YHG=2224>origin. " XBD=628 XHG=542 YBD=2258 YHG=2224>The " XBD=864 XHG=659 YBD=2258 YHG=2223>estimates " XBD=958 XHG=896 YBD=2258 YHG=2223>for " XBD=1061 XHG=990 YBD=2257 YHG=2223>the " XBD=1324 XHG=1093 YBD=2258 YHG=2223>Cambrian-" XBD=380 XHG=137 YBD=2309 YHG=2273>Ordovician " XBD=556 XHG=410 YBD=2319 YHG=2273>epochs " XBD=639 XHG=587 YBD=2308 YHG=2273>do " XBD=742 XHG=669 YBD=2308 YHG=2276>not " XBD=887 XHG=773 YBD=2308 YHG=2273>differ " XBD=1099 XHG=918 YBD=2318 YHG=2272>greatly : " XBD=1217 XHG=1146 YBD=2307 YHG=2273>the " XBD=1326 XHG=1247 YBD=2307 YHG=2272>salt" XBD=440 XHG=137 YBD=2358 YHG=2324>concentration " XBD=512 XHG=478 YBD=2357 YHG=2323>is " XBD=634 XHG=552 YBD=2358 YHG=2322>still " XBD=800 XHG=674 YBD=2358 YHG=2323>about " XBD=952 XHG=839 YBD=2358 YHG=2323>three " XBD=1110 XHG=991 YBD=2357 YHG=2323>times " XBD=1244 XHG=1149 YBD=2357 YHG=2322>that " XBD=1331 XHG=1284 YBD=2357 YHG=2321>of" XBD=397 XHG=134 YBD=2407 YHG=2372>mammalian " XBD=538 XHG=404 YBD=2414 YHG=2372>blood, " XBD=631 XHG=549 YBD=2408 YHG=2373>and " XBD=708 XHG=638 YBD=2407 YHG=2373>the " XBD=1019 XHG=718 YBD=2407 YHG=2372>concentration " XBD=1072 XHG=1028 YBD=2406 YHG=2371>of " XBD=1327 XHG=1078 YBD=2417 YHG=2372>magnesium" XBD=170 XHG=135 YBD=2457 YHG=2422>is " XBD=321 XHG=182 YBD=2468 YHG=2422>higher " XBD=439 XHG=334 YBD=2457 YHG=2422>than " XBD=548 XHG=455 YBD=2456 YHG=2422>that " XBD=611 XHG=565 YBD=2456 YHG=2421>of " XBD=858 XHG=623 YBD=2467 YHG=2423>potassium. " XBD=977 XHG=913 YBD=2456 YHG=2422>He " XBD=1040 XHG=993 YBD=2463 YHG=2422>is, " XBD=1102 XHG=1058 YBD=2455 YHG=2421>in " XBD=1244 XHG=1120 YBD=2463 YHG=2422>short, " XBD=1329 XHG=1262 YBD=2456 YHG=2421>led" XBD=180 XHG=135 YBD=2506 YHG=2475>to " XBD=362 XHG=204 YBD=2506 YHG=2471>dismiss " XBD=665 XHG=386 YBD=2506 YHG=2471>McCAijijOTM’s " XBD=810 XHG=690 YBD=2506 YHG=2472>views " XBD=878 XHG=835 YBD=2505 YHG=2482>as " XBD=926 XHG=905 YBD=2485 YHG=2470>&dquo; " XBD=1168 XHG=946 YBD=2516 YHG=2470>superficial " XBD=1327 XHG=1193 YBD=2505 YHG=2470>evolu-" XBD=341 XHG=136 YBD=2555 YHG=2520>tionism.&dquo; " XBD=614 XHG=397 YBD=2556 YHG=2520>Sea-water " XBD=717 XHG=635 YBD=2555 YHG=2520>and " XBD=805 XHG=734 YBD=2555 YHG=2521>the " XBD=947 XHG=826 YBD=2555 YHG=2520>blood " XBD=1013 XHG=968 YBD=2554 YHG=2520>of " XBD=1241 XHG=1028 YBD=2555 YHG=2520>mammals " XBD=1329 XHG=1261 YBD=2554 YHG=2531>are" XBD=462 XHG=136 YBD=2615 YHG=2568>fundamentally " XBD=632 XHG=483 YBD=2604 YHG=2569>similar " XBD=822 XHG=653 YBD=2604 YHG=2570>because " XBD=969 XHG=843 YBD=2604 YHG=2569>that’s " XBD=1060 XHG=990 YBD=2604 YHG=2570>the " XBD=1172 XHG=1082 YBD=2614 YHG=2581>way " XBD=1330 XHG=1192 YBD=2615 YHG=2569>things" XBD=232 XHG=139 YBD=2659 YHG=2629>are ; " XBD=323 XHG=264 YBD=2652 YHG=2630>we " XBD=451 XHG=340 YBD=2653 YHG=2622>must " XBD=631 XHG=467 YBD=2653 YHG=2619>become " XBD=936 XHG=649 YBD=2665 YHG=2619>sophisticated " XBD=1110 XHG=953 YBD=2663 YHG=2619>enough " XBD=1171 XHG=1127 YBD=2653 YHG=2622>to " XBD=1329 XHG=1188 YBD=2653 YHG=2618>realise" XBD=232 XHG=138 YBD=2701 YHG=2668>that " XBD=340 XHG=259 YBD=2701 YHG=2667>this " XBD=679 XHG=367 YBD=2713 YHG=2668>interpretation " XBD=739 XHG=705 YBD=2703 YHG=2669>is " XBD=839 XHG=766 YBD=2703 YHG=2671>not " XBD=1006 XHG=866 YBD=2713 YHG=2667>nearly " XBD=1077 XHG=1033 YBD=2702 YHG=2679>as " XBD=1197 XHG=1107 YBD=2713 YHG=2667>silly " XBD=1269 XHG=1225 YBD=2701 YHG=2679>as " XBD=1331 XHG=1296 YBD=2702 YHG=2668>it

VITAMIN B1 AND SHOCK" XBD=282 XHG=190 YBD=2889 YHG=2855>THE " XBD=382 XHG=299 YBD=2889 YHG=2866>war " XBD=472 XHG=399 YBD=2890 YHG=2856>has " XBD=552 XHG=487 YBD=2889 YHG=2854>led " XBD=613 XHG=568 YBD=2890 YHG=2858>to " XBD=700 XHG=630 YBD=2890 YHG=2857>the " XBD=841 XHG=718 YBD=2901 YHG=2857>study " XBD=902 XHG=858 YBD=2891 YHG=2856>of " XBD=1106 XHG=914 YBD=2891 YHG=2857>vitamins " XBD=1228 XHG=1123 YBD=2891 YHG=2856>from " XBD=1331 XHG=1245 YBD=2892 YHG=2868>new" XBD=289 XHG=143 YBD=2950 YHG=2903>angles. " XBD=422 XHG=342 YBD=2939 YHG=2903>For " XBD=636 XHG=440 YBD=2949 YHG=2904>example, " XBD=828 XHG=655 YBD=2940 YHG=2905>vitamin " XBD=881 XHG=851 YBD=2940 YHG=2906>C " XBD=977 XHG=904 YBD=2939 YHG=2906>has " XBD=1102 XHG=1000 YBD=2940 YHG=2906>been " XBD=1264 XHG=1126 YBD=2940 YHG=2906>shown " XBD=1332 XHG=1286 YBD=2941 YHG=2910>to" XBD=324 XHG=143 YBD=2988 YHG=2954>decrease " XBD=421 XHG=350 YBD=2988 YHG=2953>the " XBD=656 XHG=445 YBD=2999 YHG=2953>mortality " XBD=726 XHG=682 YBD=2988 YHG=2953>of " XBD=978 XHG=747 YBD=3000 YHG=2954>guineapigs " XBD=1213 XHG=1005 YBD=2999 YHG=2954>subjected " XBD=1282 XHG=1237 YBD=2989 YHG=2957>to " XBD=1332 XHG=1307 YBD=2989 YHG=2967>a" XBD=346 XHG=142 YBD=3045 YHG=3005>trauma,1o " XBD=449 XHG=366 YBD=3037 YHG=3003>and " XBD=510 XHG=465 YBD=3037 YHG=3005>to " XBD=695 XHG=527 YBD=3048 YHG=3002>prolong " XBD=788 XHG=718 YBD=3037 YHG=3003>the " XBD=878 XHG=809 YBD=3038 YHG=3002>life " XBD=946 XHG=902 YBD=3039 YHG=3003>of " XBD=1053 XHG=967 YBD=3038 YHG=3007>cats " XBD=1206 XHG=1075 YBD=3039 YHG=3004>which " XBD=1333 XHG=1228 YBD=3039 YHG=3004>have" XBD=243 XHG=142 YBD=3087 YHG=3053>been " XBD=591 XHG=267 YBD=3098 YHG=3051>bled-possibly " XBD=668 XHG=611 YBD=3097 YHG=3052>by " XBD=904 XHG=685 YBD=3098 YHG=3052>increasing " XBD=997 XHG=927 YBD=3087 YHG=3052>the " XBD=1274 XHG=1022 YBD=3099 YHG=3053>availability " XBD=1338 XHG=1292 YBD=3088 YHG=3053>of" XBD=301 XHG=143 YBD=3147 YHG=3113>oxygen " XBD=353 XHG=308 YBD=3137 YHG=3105>to " XBD=432 XHG=362 YBD=3136 YHG=3102>the " XBD=627 XHG=441 YBD=3136 YHG=3102>tissues " XBD=833 XHG=652 YBD=3136 YHG=3101>Vitamin " XBD=896 XHG=842 YBD=3148 YHG=3102>Bl " XBD=987 XHG=905 YBD=3137 YHG=3101>also " XBD=1069 XHG=997 YBD=3138 YHG=3102>has " XBD=1183 XHG=1082 YBD=3137 YHG=3103>been " XBD=1334 XHG=1196 YBD=3137 YHG=3103>shown" XBD=198 XHG=142 YBD=3196 YHG=3151>by " XBD=387 XHG=220 YBD=3186 YHG=3151>GOVIER " XBD=491 XHG=410 YBD=3186 YHG=3151>and " XBD=710 XHG=519 YBD=3186 YHG=3150>GREER 12 " XBD=784 XHG=739 YBD=3185 YHG=3153>to " XBD=977 XHG=811 YBD=3195 YHG=3151>prolong " XBD=1074 XHG=1004 YBD=3186 YHG=3147>the " XBD=1169 XHG=1100 YBD=3185 YHG=3151>life " XBD=1242 XHG=1198 YBD=3185 YHG=3150>of " XBD=1332 XHG=1267 YBD=3187 YHG=3163>ex-" XBD=411 XHG=144 YBD=3245 YHG=3200>sanguinated " XBD=606 XHG=423 YBD=3241 YHG=3199>animals, " XBD=702 XHG=621 YBD=3234 YHG=3200>and " XBD=759 XHG=714 YBD=3234 YHG=3202>to " XBD=962 XHG=773 YBD=3233 YHG=3199>diminish " XBD=1044 XHG=973 YBD=3234 YHG=3201>the " XBD=1334 XHG=1058 YBD=3234 YHG=3200>disturbances" XBD=185 XHG=142 YBD=3283 YHG=3249>in " XBD=509 XHG=214 YBD=3294 YHG=3249>carbohydrate " XBD=792 XHG=536 YBD=3283 YHG=3248>metabolism " XBD=1020 XHG=820 YBD=3293 YHG=3247>following " XBD=1333 XHG=1048 YBD=3294 YHG=3249>haemorrhage." XBD=198 XHG=148 YBD=3332 YHG=3298>In " XBD=317 XHG=212 YBD=3332 YHG=3298>their " XBD=419 XHG=332 YBD=3333 YHG=3298>first " XBD=702 XHG=435 YBD=3344 YHG=3299>experiments " XBD=816 XHG=717 YBD=3342 YHG=3297>they " XBD=1019 XHG=830 YBD=3331 YHG=3298>removed " XBD=1193 XHG=1032 YBD=3342 YHG=3297>rapidly " XBD=1336 XHG=1209 YBD=3332 YHG=3298>about

9. cf. Baldwin, E. Comparative Biochemistry, Cambridge, 1940.10. Ungar, G. Lancet, 1943, i, 421.11. Stewart, C. P., Learmonth, J. R., Pollock,G.A. Lancet,1941, i, 818.12. Govier, W. M., Greer, C. M. J. Pharmacol. 1941, 72, 317.

" XBD=1403 XHG=1378 YBD=236 YHG=214>a " XBD=1525 XHG=1414 YBD=236 YHG=202>third " XBD=1582 XHG=1538 YBD=237 YHG=201>of " XBD=1661 XHG=1591 YBD=237 YHG=202>the " XBD=1907 XHG=1675 YBD=248 YHG=202>circulating " XBD=2041 XHG=1920 YBD=237 YHG=202>blood " XBD=2157 XHG=2053 YBD=237 YHG=202>from " XBD=2266 XHG=2170 YBD=247 YHG=203>dogs " XBD=2524 XHG=2279 YBD=237 YHG=202>anaesthetised" XBD=1474 XHG=1376 YBD=285 YHG=251>with " XBD=1613 XHG=1490 YBD=286 YHG=251>ether. " XBD=1751 XHG=1667 YBD=286 YHG=251>The " XBD=1948 XHG=1767 YBD=292 YHG=251>animals, " XBD=2093 XHG=1964 YBD=285 YHG=250>which " XBD=2287 XHG=2108 YBD=285 YHG=251>received " XBD=2525 XHG=2300 YBD=285 YHG=251>intravenous" XBD=1459 XHG=1377 YBD=335 YHG=300>and " XBD=1789 XHG=1481 YBD=335 YHG=299>intramuscular " XBD=2023 XHG=1812 YBD=343 YHG=300>injections " XBD=2091 XHG=2047 YBD=334 YHG=300>of " XBD=2281 XHG=2111 YBD=333 YHG=300>vitamin " XBD=2352 XHG=2302 YBD=345 YHG=299>Bl " XBD=2524 XHG=2372 YBD=333 YHG=299>immedi-" XBD=1489 XHG=1378 YBD=394 YHG=348>ately " XBD=1617 XHG=1514 YBD=383 YHG=349>after " XBD=1839 XHG=1643 YBD=394 YHG=348>bleeding, " XBD=2056 XHG=1868 YBD=382 YHG=348>survived " XBD=2135 XHG=2083 YBD=382 YHG=359>on " XBD=2229 XHG=2159 YBD=382 YHG=348>the " XBD=2411 XHG=2254 YBD=392 YHG=353>average " XBD=2485 XHG=2433 YBD=382 YHG=347>for " XBD=2525 XHG=2507 YBD=382 YHG=349>8" XBD=1512 XHG=1377 YBD=438 YHG=397>hours, " XBD=1710 XHG=1535 YBD=433 YHG=398>whereas " XBD=1845 XHG=1729 YBD=431 YHG=396>those " XBD=1958 XHG=1865 YBD=431 YHG=397>that " XBD=2079 XHG=1978 YBD=431 YHG=408>were " XBD=2172 XHG=2100 YBD=431 YHG=400>not " XBD=2347 XHG=2193 YBD=430 YHG=396>treated " XBD=2453 XHG=2365 YBD=430 YHG=396>with " XBD=2526 XHG=2469 YBD=430 YHG=395>the" XBD=1562 XHG=1378 YBD=488 YHG=446>vitamin, " XBD=1682 XHG=1590 YBD=481 YHG=446>died " XBD=1810 XHG=1708 YBD=480 YHG=445>after " XBD=1944 XHG=1837 YBD=480 YHG=457>some " XBD=2019 XHG=1970 YBD=490 YHG=445>3? " XBD=2177 XHG=2044 YBD=480 YHG=446>hours. " XBD=2323 XHG=2230 YBD=479 YHG=445>This " XBD=2527 XHG=2346 YBD=479 YHG=443>difference" XBD=1459 XHG=1378 YBD=529 YHG=506>was " XBD=1630 XHG=1493 YBD=529 YHG=496>shown " XBD=1707 XHG=1661 YBD=529 YHG=498>to " XBD=1790 XHG=1739 YBD=529 YHG=495>be " XBD=2079 XHG=1823 YBD=538 YHG=493>statistically " XBD=2343 XHG=2112 YBD=539 YHG=493>significant, " XBD=2443 XHG=2376 YBD=527 YHG=493>but " XBD=2527 XHG=2469 YBD=527 YHG=493>the" XBD=1521 XHG=1377 YBD=588 YHG=544>figures " XBD=1643 XHG=1534 YBD=578 YHG=544>show " XBD=1747 XHG=1654 YBD=577 YHG=544>that " XBD=1829 XHG=1759 YBD=578 YHG=544>the " XBD=1997 XHG=1843 YBD=578 YHG=542>control " XBD=2134 XHG=2009 YBD=589 YHG=554>group " XBD=2227 XHG=2146 YBD=577 YHG=554>was " XBD=2329 XHG=2239 YBD=576 YHG=541>bled " XBD=2380 XHG=2339 YBD=576 YHG=545>to " XBD=2413 XHG=2392 YBD=575 YHG=554>a " XBD=2527 XHG=2425 YBD=575 YHG=552>some." XBD=1487 XHG=1376 YBD=627 YHG=593>what " XBD=1661 XHG=1508 YBD=638 YHG=596>greater " XBD=1822 XHG=1683 YBD=627 YHG=594>extent " XBD=1944 XHG=1842 YBD=627 YHG=592>than " XBD=2033 XHG=1963 YBD=626 YHG=591>the " XBD=2393 XHG=2054 YBD=626 YHG=590>vitamin-treated " XBD=2526 XHG=2410 YBD=636 YHG=602>group." XBD=1479 XHG=1427 YBD=676 YHG=641>In " XBD=1523 XHG=1499 YBD=676 YHG=653>a " XBD=1692 XHG=1545 YBD=676 YHG=642>second |>" XBD=1880 XHG=1715 YBD=687 YHG=644>paper,13 " XBD=2072 XHG=1906 YBD=677 YHG=641>GOVIER " XBD=2178 XHG=2098 YBD=675 YHG=641>and " XBD=2347 XHG=2204 YBD=676 YHG=640>GREER " XBD=2529 XHG=2369 YBD=685 YHG=641>reported" XBD=1470 XHG=1377 YBD=725 YHG=690>that " XBD=1814 XHG=1489 YBD=725 YHG=690>administration " XBD=1878 XHG=1833 YBD=725 YHG=690>of " XBD=2066 XHG=1892 YBD=724 YHG=691>vitamin " XBD=2137 XHG=2085 YBD=736 YHG=690>Bl " XBD=2292 XHG=2155 YBD=724 YHG=690>lowers " XBD=2376 XHG=2310 YBD=723 YHG=689>the " XBD=2482 XHG=2392 YBD=723 YHG=688>level " XBD=2531 XHG=2497 YBD=724 YHG=690>of" XBD=1612 XHG=1376 YBD=781 YHG=739>keto-acids, " XBD=1750 XHG=1633 YBD=784 YHG=750>sugar " XBD=1852 XHG=1770 YBD=774 YHG=739>and " XBD=1987 XHG=1868 YBD=773 YHG=738>lactic " XBD=2097 XHG=2007 YBD=774 YHG=739>acid " XBD=2156 XHG=2113 YBD=773 YHG=740>in " XBD=2248 XHG=2179 YBD=773 YHG=739>the " XBD=2382 XHG=2266 YBD=774 YHG=738>blood " XBD=2439 XHG=2398 YBD=772 YHG=737>of " XBD=2529 XHG=2451 YBD=784 YHG=738>dogs" XBD=1507 XHG=1377 YBD=823 YHG=788>which " XBD=1636 XHG=1531 YBD=825 YHG=789>have " XBD=1761 XHG=1660 YBD=823 YHG=788>been " XBD=1889 XHG=1785 YBD=823 YHG=787>bled. " XBD=1999 XHG=1944 YBD=822 YHG=788>As " XBD=2136 XHG=2023 YBD=822 YHG=788>these " XBD=2425 XHG=2161 YBD=822 YHG=785>observations " XBD=2529 XHG=2446 YBD=823 YHG=798>were" XBD=1494 XHG=1377 YBD=872 YHG=837>made " XBD=1554 XHG=1510 YBD=871 YHG=837>in " XBD=1739 XHG=1570 YBD=871 YHG=837>animals " XBD=1900 XHG=1754 YBD=882 YHG=837>locally " XBD=2209 XHG=1917 YBD=878 YHG=836>anaesthetised, " XBD=2323 XHG=2228 YBD=882 YHG=837>they " XBD=2530 XHG=2340 YBD=873 YHG=835>concluded" XBD=1470 XHG=1377 YBD=921 YHG=886>that " XBD=1563 XHG=1493 YBD=921 YHG=886>the " XBD=1792 XHG=1586 YBD=921 YHG=886>beneficial " XBD=1952 XHG=1815 YBD=921 YHG=886>effects " XBD=2162 XHG=1974 YBD=932 YHG=887>reported " XBD=2226 XHG=2184 YBD=920 YHG=887>in " XBD=2348 XHG=2248 YBD=921 YHG=886>their " XBD=2529 XHG=2369 YBD=932 YHG=886>previous" XBD=1502 XHG=1378 YBD=981 YHG=946>paper " XBD=1647 XHG=1529 YBD=970 YHG=935>could " XBD=1746 XHG=1672 YBD=970 YHG=939>not " XBD=1823 XHG=1773 YBD=970 YHG=936>be " XBD=1928 XHG=1850 YBD=970 YHG=936>due " XBD=1999 XHG=1955 YBD=970 YHG=938>to " XBD=2097 XHG=2026 YBD=970 YHG=936>the " XBD=2316 XHG=2125 YBD=981 YHG=935>complete " XBD=2384 XHG=2343 YBD=970 YHG=946>or " XBD=2532 XHG=2408 YBD=980 YHG=935>partial" XBD=1614 XHG=1378 YBD=1019 YHG=983>annulment " XBD=1683 XHG=1626 YBD=1030 YHG=985>by " XBD=1765 XHG=1695 YBD=1019 YHG=985>the " XBD=1951 XHG=1778 YBD=1020 YHG=985>vitamin " XBD=2008 XHG=1964 YBD=1020 YHG=984>of " XBD=2088 XHG=2017 YBD=1019 YHG=985>the " XBD=2274 XHG=2100 YBD=1019 YHG=984>harmful " XBD=2415 XHG=2286 YBD=1019 YHG=984>effects " XBD=2467 XHG=2427 YBD=1019 YHG=984>of " XBD=2530 XHG=2474 YBD=1021 YHG=985>the" XBD=1503 XHG=1379 YBD=1069 YHG=1034>ether. " XBD=1640 XHG=1557 YBD=1069 YHG=1034>The " XBD=1734 XHG=1658 YBD=1069 YHG=1034>rise " XBD=1795 XHG=1751 YBD=1069 YHG=1033>in " XBD=1930 XHG=1812 YBD=1069 YHG=1033>lactic " XBD=2038 XHG=1950 YBD=1069 YHG=1034>acid " XBD=2150 XHG=2058 YBD=1069 YHG=1046>seen " XBD=2271 XHG=2169 YBD=1069 YHG=1033>after " XBD=2530 XHG=2289 YBD=1081 YHG=1034>haemorrhage" XBD=1411 XHG=1378 YBD=1118 YHG=1084>is " XBD=1515 XHG=1441 YBD=1118 YHG=1087>not " XBD=1589 XHG=1545 YBD=1119 YHG=1083>of " XBD=1892 XHG=1616 YBD=1129 YHG=1083>significance ; " XBD=2015 XHG=1940 YBD=1119 YHG=1084>but " XBD=2116 XHG=2045 YBD=1119 YHG=1084>the " XBD=2387 XHG=2144 YBD=1129 YHG=1084>importance " XBD=2454 XHG=2414 YBD=1119 YHG=1083>of " XBD=2531 XHG=2476 YBD=1121 YHG=1085>the" XBD=1582 XHG=1378 YBD=1168 YHG=1134>increased " XBD=1822 XHG=1604 YBD=1178 YHG=1133>quantities " XBD=1887 XHG=1843 YBD=1168 YHG=1132>of " XBD=2128 XHG=1903 YBD=1168 YHG=1133>keto-acids " XBD=2181 XHG=2148 YBD=1167 YHG=1134>is " XBD=2310 XHG=2201 YBD=1168 YHG=1145>more " XBD=2481 XHG=2322 YBD=1168 YHG=1132>-difficult " XBD=2531 XHG=2497 YBD=1170 YHG=1137>to" XBD=1518 XHG=1379 YBD=1217 YHG=1194>assess. " XBD=1613 XHG=1571 YBD=1219 YHG=1183>It " XBD=1662 XHG=1628 YBD=1216 YHG=1183>is " XBD=1750 XHG=1678 YBD=1217 YHG=1185>not " XBD=1869 XHG=1767 YBD=1217 YHG=1183>clear " XBD=1978 XHG=1885 YBD=1228 YHG=1183>why " XBD=2106 XHG=1993 YBD=1217 YHG=1183>there " XBD=2265 XHG=2123 YBD=1217 YHG=1182>should " XBD=2328 XHG=2279 YBD=1217 YHG=1183>be " XBD=2366 XHG=2343 YBD=1218 YHG=1195>a " XBD=2531 XHG=2380 YBD=1228 YHG=1183>need for" XBD=1552 XHG=1379 YBD=1267 YHG=1232>vitamin " XBD=1630 XHG=1576 YBD=1279 YHG=1231>Bl " XBD=1759 XHG=1656 YBD=1266 YHG=1231>after " XBD=2056 XHG=1785 YBD=1278 YHG=1232>haemorrhage " XBD=2125 XHG=2082 YBD=1266 YHG=1232>in " XBD=2174 XHG=2150 YBD=1266 YHG=1243>a " XBD=2362 XHG=2200 YBD=1278 YHG=1232>healthy " XBD=2531 XHG=2386 YBD=1270 YHG=1232>well-fed" XBD=1483 XHG=1379 YBD=1327 YHG=1282>dog : " XBD=1679 XHG=1513 YBD=1317 YHG=1282>GOVIER " XBD=1773 XHG=1692 YBD=1316 YHG=1282>and " XBD=1934 XHG=1786 YBD=1317 YHG=1282>GREER " XBD=2158 XHG=1948 YBD=1328 YHG=1281>suggested " XBD=2262 XHG=2170 YBD=1317 YHG=1282>that " XBD=2445 XHG=2274 YBD=1328 YHG=1282>bleeding " XBD=2533 XHG=2456 YBD=1330 YHG=1294>may" XBD=1496 XHG=1379 YBD=1367 YHG=1332>lower " XBD=1565 XHG=1521 YBD=1366 YHG=1332>in " XBD=1699 XHG=1590 YBD=1367 YHG=1343>some " XBD=1814 XHG=1723 YBD=1377 YHG=1343>way " XBD=1907 XHG=1837 YBD=1366 YHG=1331>the " XBD=2106 XHG=1933 YBD=1366 YHG=1331>thiamin " XBD=2231 XHG=2129 YBD=1366 YHG=1331>level " XBD=2300 XHG=2257 YBD=1367 YHG=1331>of " XBD=2387 XHG=2320 YBD=1366 YHG=1332>the " XBD=2529 XHG=2409 YBD=1369 YHG=1333>tissues" XBD=1591 XHG=1380 YBD=1427 YHG=1380>generally. " XBD=1754 XHG=1644 YBD=1416 YHG=1381>More " XBD=1950 XHG=1772 YBD=1426 YHG=1380>recently " XBD=2171 XHG=1968 YBD=1416 YHG=1381>GOVIER 14 " XBD=2260 XHG=2188 YBD=1415 YHG=1381>has " XBD=2470 XHG=2280 YBD=1417 YHG=1382>described " XBD=2533 XHG=2485 YBD=1418 YHG=1382>his" XBD=1532 XHG=1381 YBD=1466 YHG=1431>studies " XBD=1607 XHG=1554 YBD=1465 YHG=1442>on " XBD=1697 XHG=1626 YBD=1465 YHG=1431>the " XBD=1977 XHG=1718 YBD=1476 YHG=1430>relationship " XBD=2178 XHG=1999 YBD=1465 YHG=1430>between " XBD=2268 XHG=2198 YBD=1465 YHG=1430>the " XBD=2433 XHG=2288 YBD=1476 YHG=1430>plasma " XBD=2533 XHG=2451 YBD=1466 YHG=1431>level" XBD=1426 XHG=1381 YBD=1516 YHG=1480>of " XBD=1630 XHG=1457 YBD=1515 YHG=1480>vitamin " XBD=1716 XHG=1664 YBD=1526 YHG=1480>Bl " XBD=1834 XHG=1752 YBD=1514 YHG=1479>and " XBD=1938 XHG=1868 YBD=1514 YHG=1480>the " XBD=2187 XHG=1972 YBD=1514 YHG=1480>resistance " XBD=2265 XHG=2222 YBD=1514 YHG=1483>to " XBD=2416 XHG=2301 YBD=1515 YHG=1480>shock " XBD=2532 XHG=2449 YBD=1517 YHG=1480>after" XBD=1663 XHG=1380 YBD=1575 YHG=1530>haemorrhage. " XBD=1781 XHG=1718 YBD=1564 YHG=1529>He " XBD=1932 XHG=1804 YBD=1564 YHG=1529>found " XBD=2047 XHG=1955 YBD=1564 YHG=1529>that " XBD=2116 XHG=2072 YBD=1564 YHG=1532>to " XBD=2307 XHG=2135 YBD=1575 YHG=1530>produce " XBD=2353 XHG=2330 YBD=1564 YHG=1542>a " XBD=2530 XHG=2375 YBD=1576 YHG=1542>perman." XBD=1495 XHG=1381 YBD=1625 YHG=1579>ently " XBD=1700 XHG=1528 YBD=1614 YHG=1579>lowered " XBD=2052 XHG=1734 YBD=1625 YHG=1578>blood-pressure " XBD=2187 XHG=2090 YBD=1625 YHG=1580>dogs " XBD=2368 XHG=2222 YBD=1625 YHG=1579>having " XBD=2423 XHG=2401 YBD=1614 YHG=1592>a " XBD=2531 XHG=2454 YBD=1626 YHG=1580>high" XBD=1725 XHG=1381 YBD=1675 YHG=1628>plasma-thiamin " XBD=1818 XHG=1752 YBD=1676 YHG=1629>(4y " XBD=1902 XHG=1833 YBD=1675 YHG=1640>per " XBD=1992 XHG=1921 YBD=1664 YHG=1630>100 " XBD=2120 XHG=2009 YBD=1664 YHG=1641>c.cm. " XBD=2219 XHG=2138 YBD=1663 YHG=1629>and " XBD=2373 XHG=2234 YBD=1673 YHG=1629>above) " XBD=2484 XHG=2389 YBD=1665 YHG=1621>must " XBD=2534 XHG=2495 YBD=1665 YHG=1630>be" XBD=1474 XHG=1381 YBD=1714 YHG=1678>bled " XBD=1597 XHG=1489 YBD=1714 YHG=1690>some " XBD=1709 XHG=1611 YBD=1726 YHG=1679>45% " XBD=1834 XHG=1724 YBD=1713 YHG=1690>more " XBD=1956 XHG=1854 YBD=1713 YHG=1679>than " XBD=2090 XHG=1974 YBD=1714 YHG=1679>those " XBD=2152 XHG=2110 YBD=1713 YHG=1679>in " XBD=2293 XHG=2165 YBD=1713 YHG=1679>which " XBD=2379 XHG=2312 YBD=1713 YHG=1679>the " XBD=2533 XHG=2392 YBD=1725 YHG=1679>plasma-" XBD=1555 XHG=1382 YBD=1764 YHG=1729>thiamin " XBD=1606 XHG=1572 YBD=1763 YHG=1729>is " XBD=1700 XHG=1623 YBD=1764 YHG=1728>low " XBD=1862 XHG=1717 YBD=1776 YHG=1729>(0-2y). " XBD=2032 XHG=1901 YBD=1764 YHG=1728>When " XBD=2144 XHG=2046 YBD=1774 YHG=1729>dogs " XBD=2261 XHG=2161 YBD=1763 YHG=1740>were " XBD=2442 XHG=2277 YBD=1764 YHG=1728>fortified " XBD=2532 XHG=2456 YBD=1764 YHG=1729>with" XBD=1559 XHG=1383 YBD=1814 YHG=1779>vitamin " XBD=1653 XHG=1600 YBD=1825 YHG=1778>Bl " XBD=1827 XHG=1694 YBD=1813 YHG=1777>before " XBD=2062 XHG=1867 YBD=1824 YHG=1777>bleeding, " XBD=2210 XHG=2107 YBD=1813 YHG=1778>their " XBD=2531 XHG=2250 YBD=1825 YHG=1775>blood-pressure" XBD=1533 XHG=1384 YBD=1863 YHG=1828>tended " XBD=1590 XHG=1545 YBD=1863 YHG=1831>to " XBD=1742 XHG=1603 YBD=1862 YHG=1832>return " XBD=1799 XHG=1754 YBD=1862 YHG=1831>to " XBD=1967 XHG=1812 YBD=1863 YHG=1828>normal " XBD=2085 XHG=1981 YBD=1863 YHG=1827>after " XBD=2375 XHG=2098 YBD=1873 YHG=1828>haemorrhage, " XBD=2532 XHG=2389 YBD=1863 YHG=1828>whereas" XBD=1554 XHG=1386 YBD=1912 YHG=1877>animals " XBD=1762 XHG=1577 YBD=1912 YHG=1877>deficient " XBD=1826 XHG=1784 YBD=1912 YHG=1878>in " XBD=2023 XHG=1850 YBD=1912 YHG=1877>vitamin " XBD=2102 XHG=2048 YBD=1924 YHG=1877>Bi " XBD=2336 XHG=2120 YBD=1923 YHG=1877>developed " XBD=2533 XHG=2352 YBD=1923 YHG=1878>persistent" XBD=1654 XHG=1386 YBD=1973 YHG=1928>hypotension " XBD=1775 XHG=1677 YBD=1963 YHG=1939>soon " XBD=1900 XHG=1798 YBD=1962 YHG=1926>after " XBD=1993 XHG=1923 YBD=1962 YHG=1928>the " XBD=2095 XHG=2015 YBD=1962 YHG=1927>loss " XBD=2162 XHG=2118 YBD=1962 YHG=1926>of " XBD=2295 XHG=2181 YBD=1962 YHG=1925>small " XBD=2485 XHG=2316 YBD=1962 YHG=1929>amounts " XBD=2536 XHG=2503 YBD=1961 YHG=1926>of" XBD=1519 XHG=1386 YBD=2012 YHG=1977>blood. " XBD=1656 XHG=1572 YBD=2012 YHG=1977>The " XBD=1876 XHG=1674 YBD=2012 YHG=1977>incidence " XBD=1940 XHG=1895 YBD=2012 YHG=1976>of " XBD=2160 XHG=1953 YBD=2012 YHG=1975>intestinal " XBD=2437 XHG=2178 YBD=2023 YHG=1976>haemorrhage " XBD=2533 XHG=2452 YBD=2011 YHG=1975>after" XBD=1569 XHG=1386 YBD=2074 YHG=2027>bleeding " XBD=1670 XHG=1589 YBD=2063 YHG=2039>was " XBD=1809 XHG=1689 YBD=2063 YHG=2028>much " XBD=1983 XHG=1829 YBD=2073 YHG=2030>greater " XBD=2044 XHG=2002 YBD=2061 YHG=2027>in " XBD=2232 XHG=2064 YBD=2062 YHG=2026>animals " XBD=2426 XHG=2251 YBD=2062 YHG=2026>deficient " XBD=2480 XHG=2442 YBD=2062 YHG=2027>in " XBD=2533 XHG=2493 YBD=2074 YHG=2026>Bl" XBD=1488 XHG=1385 YBD=2113 YHG=2079>than " XBD=1550 XHG=1508 YBD=2112 YHG=2077>in " XBD=1686 XHG=1570 YBD=2112 YHG=2078>those " XBD=1804 XHG=1707 YBD=2112 YHG=2077>with " XBD=1921 XHG=1824 YBD=2122 YHG=2077>high " XBD=2284 XHG=1941 YBD=2123 YHG=2076>plasma-thiamin " XBD=2440 XHG=2303 YBD=2118 YHG=2076>levels; " XBD=2533 XHG=2461 YBD=2117 YHG=2075>and," XBD=1537 XHG=1386 YBD=2172 YHG=2127>finally, " XBD=1626 XHG=1556 YBD=2161 YHG=2127>the " XBD=1987 XHG=1643 YBD=2172 YHG=2127>plasma-thiamin " XBD=2088 XHG=2000 YBD=2162 YHG=2138>rose " XBD=2150 XHG=2106 YBD=2161 YHG=2138>as " XBD=2236 XHG=2166 YBD=2162 YHG=2127>the " XBD=2534 XHG=2253 YBD=2172 YHG=2125>blood-pressure" XBD=1467 XHG=1387 YBD=2213 YHG=2176>fell. " XBD=1646 XHG=1520 YBD=2211 YHG=2177>These " XBD=1931 XHG=1665 YBD=2223 YHG=2177>experiments " XBD=2055 XHG=1951 YBD=2211 YHG=2188>seem " XBD=2127 XHG=2083 YBD=2211 YHG=2179>to " XBD=2264 XHG=2155 YBD=2211 YHG=2176>show " XBD=2379 XHG=2289 YBD=2210 YHG=2176>that " XBD=2535 XHG=2395 YBD=2210 YHG=2174>vitamin" XBD=1441 XHG=1388 YBD=2274 YHG=2227>Bl " XBD=1652 XHG=1457 YBD=2261 YHG=2226>increases " XBD=1739 XHG=1668 YBD=2262 YHG=2227>the " XBD=1969 XHG=1754 YBD=2261 YHG=2227>resistance " XBD=2030 XHG=1986 YBD=2261 YHG=2225>of " XBD=2212 XHG=2044 YBD=2261 YHG=2225>animals " XBD=2273 XHG=2229 YBD=2261 YHG=2229>to " XBD=2356 XHG=2289 YBD=2260 YHG=2225>the " XBD=2490 XHG=2371 YBD=2260 YHG=2224>effects " XBD=2537 XHG=2504 YBD=2259 YHG=2222>of" XBD=1672 XHG=1389 YBD=2322 YHG=2277>haemorrhage, " XBD=1791 XHG=1710 YBD=2311 YHG=2275>and " XBD=1993 XHG=1827 YBD=2311 YHG=2276>GOVIER " XBD=2222 XHG=2027 YBD=2311 YHG=2276>discusses " XBD=2362 XHG=2258 YBD=2310 YHG=2287>some " XBD=2535 XHG=2393 YBD=2321 YHG=2273>possible" XBD=1680 XHG=1389 YBD=2373 YHG=2326>explanations. " XBD=1907 XHG=1734 YBD=2372 YHG=2326>Hepatic " XBD=2263 XHG=1951 YBD=2372 YHG=2325>glycogenolysis " XBD=2381 XHG=2305 YBD=2361 YHG=2325>and " XBD=2534 XHG=2419 YBD=2371 YHG=2325>hyper-" XBD=1596 XHG=1389 YBD=2423 YHG=2376>glycaemia " XBD=1719 XHG=1615 YBD=2412 YHG=2375>after " XBD=2009 XHG=1738 YBD=2421 YHG=2376>haemorrhage " XBD=2110 XHG=2029 YBD=2411 YHG=2375>will " XBD=2301 XHG=2128 YBD=2410 YHG=2376>increase " XBD=2386 XHG=2320 YBD=2410 YHG=2376>the " XBD=2535 XHG=2407 YBD=2420 YHG=2373>quanti-" XBD=1465 XHG=1389 YBD=2461 YHG=2427>ties " XBD=1527 XHG=1483 YBD=2461 YHG=2425>of " XBD=1762 XHG=1539 YBD=2461 YHG=2426>keto-acids " XBD=1982 XHG=1778 YBD=2471 YHG=2426>produced " XBD=2040 XHG=1997 YBD=2460 YHG=2426>in " XBD=2126 XHG=2056 YBD=2460 YHG=2426>the " XBD=2416 XHG=2141 YBD=2470 YHG=2425>intermediary " XBD=2536 XHG=2431 YBD=2471 YHG=2427>stages" XBD=1435 XHG=1392 YBD=2510 YHG=2475>of " XBD=1776 XHG=1484 YBD=2520 YHG=2475>carbohydrate " XBD=2093 XHG=1825 YBD=2517 YHG=2475>metabolism, " XBD=2205 XHG=2142 YBD=2510 YHG=2474>for " XBD=2323 XHG=2254 YBD=2511 YHG=2475>the " XBD=2536 XHG=2371 YBD=2520 YHG=2474>complete" XBD=1600 XHG=1392 YBD=2560 YHG=2525>oxidation " XBD=1661 XHG=1617 YBD=2560 YHG=2524>of " XBD=1804 XHG=1675 YBD=2559 YHG=2525>which " XBD=2024 XHG=1820 YBD=2560 YHG=2525>increased " XBD=2259 XHG=2042 YBD=2570 YHG=2524>quantities " XBD=2319 XHG=2276 YBD=2560 YHG=2524>of " XBD=2484 XHG=2331 YBD=2559 YHG=2524>vitamin " XBD=2537 XHG=2497 YBD=2569 YHG=2523>Bl" XBD=1472 XHG=1391 YBD=2610 YHG=2574>will " XBD=1542 XHG=1492 YBD=2610 YHG=2575>be " XBD=1726 XHG=1563 YBD=2609 YHG=2574>needed. " XBD=1831 XHG=1780 YBD=2608 YHG=2574>In " XBD=1956 XHG=1851 YBD=2609 YHG=2574>their " XBD=2147 XHG=1978 YBD=2609 YHG=2575>absence " XBD=2237 XHG=2168 YBD=2610 YHG=2574>the " XBD=2488 XHG=2258 YBD=2610 YHG=2573>metabolism " XBD=2540 XHG=2506 YBD=2608 YHG=2570>of" XBD=1462 XHG=1391 YBD=2660 YHG=2624>the " XBD=1803 XHG=1479 YBD=2670 YHG=2623>predominantly " XBD=2301 XHG=1822 YBD=2670 YHG=2624>carbohydrate-burning " XBD=2448 XHG=2317 YBD=2659 YHG=2624>tissues " XBD=2537 XHG=2463 YBD=2668 YHG=2632>may" XBD=1443 XHG=1392 YBD=2708 YHG=2673>be " XBD=1729 XHG=1466 YBD=2719 YHG=2674>interrupted, " XBD=1946 XHG=1753 YBD=2720 YHG=2673>resulting " XBD=2012 XHG=1969 YBD=2708 YHG=2675>in " XBD=2290 XHG=2034 YBD=2719 YHG=2674>impairment " XBD=2355 XHG=2313 YBD=2709 YHG=2673>of " XBD=2535 XHG=2372 YBD=2710 YHG=2673>function." XBD=1476 XHG=1392 YBD=2758 YHG=2723>The " XBD=1697 XHG=1490 YBD=2758 YHG=2722>intestinal " XBD=1979 XHG=1710 YBD=2769 YHG=2723>haemorrhage " XBD=2089 XHG=1994 YBD=2768 YHG=2735>may " XBD=2154 XHG=2103 YBD=2758 YHG=2724>be " XBD=2246 XHG=2168 YBD=2758 YHG=2723>due " XBD=2302 XHG=2259 YBD=2758 YHG=2727>to " XBD=2536 XHG=2317 YBD=2759 YHG=2723>constriction" XBD=1437 XHG=1393 YBD=2807 YHG=2772>of " XBD=1521 XHG=1451 YBD=2807 YHG=2773>the " XBD=1698 XHG=1538 YBD=2818 YHG=2772>hepatic " XBD=1870 XHG=1716 YBD=2814 YHG=2773>veins,15 " XBD=1933 XHG=1889 YBD=2808 YHG=2784>or " XBD=1995 XHG=1950 YBD=2807 YHG=2776>to " XBD=2190 XHG=2017 YBD=2819 YHG=2772>swelling " XBD=2255 XHG=2212 YBD=2807 YHG=2772>of " XBD=2339 XHG=2272 YBD=2808 YHG=2773>the " XBD=2536 XHG=2358 YBD=2819 YHG=2770>polygonal" XBD=1486 XHG=1395 YBD=2856 YHG=2821>cells " XBD=1543 XHG=1499 YBD=2857 YHG=2821>of " XBD=1620 XHG=1551 YBD=2856 YHG=2822>the liver .6 " XBD=1993 XHG=1824 YBD=2868 YHG=2821>Against " XBD=2263 XHG=2005 YBD=2857 YHG=2823>constriction " XBD=2320 XHG=2276 YBD=2857 YHG=2822>of " XBD=2394 XHG=2329 YBD=2857 YHG=2823>the " XBD=2536 XHG=2406 YBD=2869 YHG=2822>hepatic" XBD=1520 XHG=1395 YBD=2912 YHG=2871>veins, " XBD=1715 XHG=1542 YBD=2906 YHG=2871>vitamin " XBD=1788 XHG=1735 YBD=2917 YHG=2870>Bl " XBD=1939 XHG=1808 YBD=2917 YHG=2872>might " XBD=2010 XHG=1959 YBD=2906 YHG=2871>be " XBD=2076 XHG=2031 YBD=2905 YHG=2870>of " XBD=2242 XHG=2094 YBD=2906 YHG=2871>benefit " XBD=2317 XHG=2263 YBD=2917 YHG=2871>by " XBD=2535 XHG=2336 YBD=2916 YHG=2872>reinforcing" XBD=1770 XHG=1396 YBD=2965 YHG=2919>acetylcholine-if " XBD=1934 XHG=1788 YBD=2955 YHG=2920>indeed " XBD=2037 XHG=1955 YBD=2955 YHG=2920>this " XBD=2133 XHG=2059 YBD=2955 YHG=2920>has " XBD=2179 XHG=2155 YBD=2955 YHG=2933>a " XBD=2343 XHG=2203 YBD=2956 YHG=2921>dilator " XBD=2481 XHG=2363 YBD=2956 YHG=2921>action " XBD=2536 XHG=2498 YBD=2956 YHG=2931>on" XBD=1519 XHG=1394 YBD=3004 YHG=2969>them. " XBD=1627 XHG=1574 YBD=3004 YHG=2969>Or " XBD=1677 XHG=1642 YBD=3004 YHG=2970>it " XBD=1820 XHG=1692 YBD=3015 YHG=2969>might " XBD=1941 XHG=1836 YBD=3004 YHG=2970>have " XBD=2065 XHG=1957 YBD=3005 YHG=2981>some " XBD=2301 XHG=2080 YBD=3016 YHG=2971>protective " XBD=2485 XHG=2314 YBD=3006 YHG=2970>influence " XBD=2536 XHG=2498 YBD=3006 YHG=2980>on" XBD=1464 XHG=1394 YBD=3053 YHG=3019>the " XBD=1580 XHG=1481 YBD=3053 YHG=3018>liver " XBD=1703 XHG=1600 YBD=3054 YHG=3018>cells." XBD=1589 XHG=1446 YBD=3102 YHG=3067>Before " XBD=1675 XHG=1605 YBD=3103 YHG=3069>the " XBD=1780 XHG=1691 YBD=3102 YHG=3072>true " XBD=1915 XHG=1796 YBD=3103 YHG=3068>value " XBD=1975 XHG=1931 YBD=3103 YHG=3067>of " XBD=2159 XHG=1987 YBD=3103 YHG=3068>vitamin " XBD=2227 XHG=2174 YBD=3114 YHG=3069>Bl " XBD=2283 XHG=2242 YBD=3103 YHG=3069>in " XBD=2411 XHG=2298 YBD=3104 YHG=3069>shock " XBD=2487 XHG=2425 YBD=3105 YHG=3081>can " XBD=2536 XHG=2498 YBD=3105 YHG=3070>be" XBD=1574 XHG=1396 YBD=3151 YHG=3117>assessed " XBD=1670 XHG=1599 YBD=3151 YHG=3117>the " XBD=1805 XHG=1696 YBD=3152 YHG=3117>work " XBD=1877 XHG=1833 YBD=3152 YHG=3117>of |>" XBD=2066 XHG=1900 YBD=3152 YHG=3116>GoviER " XBD=2174 XHG=2093 YBD=3152 YHG=3118>and |>" XBD=2346 XHG=2201 YBD=3153 YHG=3118>GREER " XBD=2437 XHG=2367 YBD=3153 YHG=3117>will " XBD=2536 XHG=2459 YBD=3154 YHG=3117>need" XBD=1689 XHG=1399 YBD=3201 YHG=3165>confirmation. " XBD=1798 XHG=1742 YBD=3201 YHG=3166>At " XBD=1926 XHG=1823 YBD=3208 YHG=3167>best, " XBD=2126 XHG=1953 YBD=3201 YHG=3167>vitamin |>" XBD=2204 XHG=2151 YBD=3213 YHG=3167>Bl " XBD=2304 XHG=2231 YBD=3202 YHG=3178>can " XBD=2373 XHG=2327 YBD=3202 YHG=3167>be " XBD=2477 XHG=2396 YBD=3213 YHG=3166>only " XBD=2535 XHG=2496 YBD=3203 YHG=3178>an" XBD=1596 XHG=1397 YBD=3258 YHG=3214>adjuvant " XBD=1659 XHG=1615 YBD=3249 YHG=3218>to " XBD=1936 XHG=1678 YBD=3256 YHG=3214>transfusion, " XBD=2038 XHG=1957 YBD=3249 YHG=3215>and " XBD=2192 XHG=2057 YBD=3249 YHG=3214>before " XBD=2263 XHG=2210 YBD=3250 YHG=3216>its " XBD=2425 XHG=2281 YBD=3260 YHG=3216>general " XBD=2496 XHG=2440 YBD=3251 YHG=3228>use " XBD=2535 XHG=2510 YBD=3250 YHG=3216>is" XBD=1697 XHG=1399 YBD=3308 YHG=3263>contemplated " XBD=1905 XHG=1735 YBD=3298 YHG=3275>answers " XBD=2054 XHG=1944 YBD=3298 YHG=3266>must " XBD=2142 XHG=2092 YBD=3297 YHG=3264>be " XBD=2304 XHG=2179 YBD=3298 YHG=3263>found " XBD=2379 XHG=2338 YBD=3298 YHG=3268>to " XBD=2534 XHG=2414 YBD=3300 YHG=3263>several" XBD=1617 XHG=1400 YBD=3357 YHG=3312>questions. " XBD=1769 XHG=1661 YBD=3356 YHG=3312>Why " XBD=1814 XHG=1780 YBD=3345 YHG=3312>is " XBD=1939 XHG=1826 YBD=3346 YHG=3312>there " XBD=1975 XHG=1952 YBD=3346 YHG=3323>a " XBD=2143 XHG=1989 YBD=3357 YHG=3314>greater " XBD=2256 XHG=2156 YBD=3347 YHG=3312>need " XBD=2326 XHG=2267 YBD=3347 YHG=3312>for " XBD=2486 XHG=2338 YBD=3347 YHG=3313>vitamin " XBD=2533 XHG=2494 YBD=3358 YHG=3313>Bl

13. J. Pharmacol. 1941, 72, 321.14. Govier, W. M. Ibid, 1943, 77, 40. 15. Lamson, P. Ibid, 1920, 16, 125.16. Bainbridge, F. A. and Trevan, J. W. J. Physiol. 1917, 16, 460.

561

" XBD=220 XHG=130 YBD=243 YHG=206>after " XBD=509 XHG=232 YBD=253 YHG=208>haemorrhage, " XBD=609 XHG=527 YBD=242 YHG=207>and " XBD=715 XHG=624 YBD=242 YHG=207>how " XBD=825 XHG=730 YBD=242 YHG=207>does " XBD=874 XHG=840 YBD=242 YHG=207>it " XBD=1004 XHG=891 YBD=242 YHG=211>exert " XBD=1072 XHG=1019 YBD=241 YHG=208>its " XBD=1295 XHG=1089 YBD=242 YHG=207>beneficial" XBD=288 XHG=130 YBD=292 YHG=256>effect ? " XBD=420 XHG=316 YBD=291 YHG=256>Does " XBD=471 XHG=438 YBD=291 YHG=257>it " XBD=597 XHG=491 YBD=291 YHG=256>have " XBD=697 XHG=616 YBD=290 YHG=256>this " XBD=838 XHG=720 YBD=290 YHG=255>effect " XBD=900 XHG=857 YBD=290 YHG=256>in " XBD=1043 XHG=920 YBD=290 YHG=255>shock " XBD=1178 XHG=1064 YBD=290 YHG=256>other " XBD=1297 XHG=1195 YBD=290 YHG=256>than" XBD=209 XHG=130 YBD=342 YHG=307>that " XBD=419 XHG=224 YBD=351 YHG=305>following " XBD=742 XHG=437 YBD=349 YHG=304>haemorrhage ? 1 " XBD=906 XHG=800 YBD=339 YHG=304>Does " XBD=959 XHG=924 YBD=339 YHG=305>it " XBD=1080 XHG=976 YBD=338 YHG=304>have " XBD=1169 XHG=1099 YBD=338 YHG=303>the " XBD=1295 XHG=1188 YBD=338 YHG=315>same" XBD=317 XHG=130 YBD=392 YHG=353>beneficial " XBD=466 XHG=350 YBD=388 YHG=353>effect " XBD=542 XHG=498 YBD=387 YHG=354>in " XBD=671 XHG=575 YBD=387 YHG=364>man " XBD=748 XHG=704 YBD=387 YHG=364>as " XBD=824 XHG=780 YBD=386 YHG=353>in " XBD=1058 XHG=856 YBD=387 YHG=351>animals ? 1 " XBD=1192 XHG=1114 YBD=386 YHG=351>Are " XBD=1296 XHG=1225 YBD=386 YHG=352>the" XBD=285 XHG=128 YBD=440 YHG=414>reserves " XBD=352 XHG=307 YBD=437 YHG=400>of " XBD=541 XHG=369 YBD=437 YHG=402>vitamin " XBD=617 XHG=564 YBD=447 YHG=402>Bl " XBD=682 XHG=639 YBD=435 YHG=402>in " XBD=775 XHG=705 YBD=435 YHG=402>the " XBD=1117 XHG=797 YBD=436 YHG=400>well-nourished " XBD=1295 XHG=1139 YBD=435 YHG=400>normal" XBD=255 XHG=128 YBD=500 YHG=462>person " XBD=505 XHG=267 YBD=486 YHG=450>insufficient " XBD=564 XHG=520 YBD=484 YHG=453>to " XBD=686 XHG=579 YBD=484 YHG=452>meet " XBD=771 XHG=701 YBD=483 YHG=450>the " XBD=906 XHG=785 YBD=484 YHG=449>needs " XBD=968 XHG=922 YBD=483 YHG=448>of " XBD=1049 XHG=979 YBD=483 YHG=449>the " XBD=1175 XHG=1064 YBD=494 YHG=449>body " XBD=1294 XHG=1190 YBD=483 YHG=448>after" XBD=410 XHG=128 YBD=545 YHG=500>haemorrhage ?

Annotations

SULPHONAMIDES BY UNFREQUENTED ROUTES

" XBD=208 XHG=166 YBD=782 YHG=752>IN " XBD=283 XHG=221 YBD=783 YHG=751>the " XBD=398 XHG=296 YBD=791 YHG=751>early " XBD=506 XHG=412 YBD=789 YHG=751>days " XBD=560 XHG=520 YBD=780 YHG=751>of " XBD=859 XHG=572 YBD=789 YHG=751>sulphonamide " XBD=1047 XHG=872 YBD=789 YHG=751>therapy, " XBD=1084 XHG=1061 YBD=780 YHG=759>a " XBD=1294 XHG=1097 YBD=781 YHG=751>saturated" XBD=272 XHG=125 YBD=827 YHG=795>solution " XBD=332 XHG=293 YBD=825 YHG=795>of " XBD=668 XHG=352 YBD=833 YHG=793>sulphanilamide |>" XBD=813 XHG=690 YBD=833 YHG=793>(0.8% " XBD=876 XHG=835 YBD=824 YHG=795>at " XBD=1000 XHG=896 YBD=833 YHG=793>body " XBD=1293 XHG=1021 YBD=834 YHG=795>temperature)" XBD=189 XHG=123 YBD=870 YHG=847>was " XBD=332 XHG=224 YBD=878 YHG=838>given " XBD=691 XHG=370 YBD=877 YHG=837>subcutaneously " XBD=807 XHG=730 YBD=868 YHG=838>and " XBD=1113 XHG=843 YBD=877 YHG=837>intrathecally " XBD=1189 XHG=1149 YBD=868 YHG=837>in " XBD=1294 XHG=1227 YBD=869 YHG=838>the" XBD=313 XHG=124 YBD=913 YHG=883>treatment " XBD=392 XHG=353 YBD=912 YHG=882>of " XBD=576 XHG=431 YBD=912 YHG=881>several " XBD=726 XHG=615 YBD=912 YHG=881>small " XBD=874 XHG=763 YBD=912 YHG=881>series " XBD=954 XHG=914 YBD=912 YHG=881>of " XBD=1295 XHG=992 YBD=921 YHG=882>meningococcal" XBD=349 XHG=124 YBD=965 YHG=925>meningitis.1- " XBD=486 XHG=397 YBD=956 YHG=924>This " XBD=660 XHG=504 YBD=956 YHG=925>method " XBD=774 XHG=681 YBD=956 YHG=934>soon " XBD=850 XHG=785 YBD=956 YHG=925>fell " XBD=951 XHG=869 YBD=956 YHG=925>into " XBD=1163 XHG=972 YBD=965 YHG=926>abeyance " XBD=1293 XHG=1183 YBD=958 YHG=926>when" XBD=148 XHG=123 YBD=1001 YHG=970>it " XBD=245 XHG=174 YBD=1001 YHG=978>was " XBD=402 XHG=274 YBD=1001 YHG=970>shown " XBD=528 XHG=432 YBD=1000 YHG=969>both " XBD=897 XHG=558 YBD=1009 YHG=963>experimentally and " XBD=1073 XHG=1034 YBD=1001 YHG=969>in " XBD=1292 XHG=1103 YBD=1001 YHG=970>humans " XBD=1292 XHG=1279 YBD=989 YHG=970>3" XBD=197 XHG=123 YBD=1045 YHG=1014>that " XBD=532 XHG=228 YBD=1045 YHG=1013>administration " XBD=617 XHG=564 YBD=1053 YHG=1013>by " XBD=784 XHG=649 YBD=1045 YHG=1014>mouth " XBD=892 XHG=814 YBD=1045 YHG=1024>was " XBD=1075 XHG=923 YBD=1054 YHG=1014>equally " XBD=1291 XHG=1107 YBD=1046 YHG=1014>effective." XBD=325 XHG=123 YBD=1089 YHG=1058>Parenteral " XBD=675 XHG=368 YBD=1089 YHG=1058>administration " XBD=759 XHG=720 YBD=1089 YHG=1058>of " XBD=868 XHG=801 YBD=1089 YHG=1058>the " XBD=1218 XHG=911 YBD=1098 YHG=1058>sulphonamides " XBD=1293 XHG=1261 YBD=1090 YHG=1059>is" XBD=266 XHG=124 YBD=1132 YHG=1101>difficult " XBD=451 XHG=291 YBD=1133 YHG=1102>because " XBD=516 XHG=477 YBD=1133 YHG=1102>of " XBD=642 XHG=542 YBD=1133 YHG=1102>their " XBD=740 XHG=666 YBD=1133 YHG=1102>low " XBD=961 XHG=765 YBD=1142 YHG=1102>solubility " XBD=1026 XHG=986 YBD=1133 YHG=1103>in " XBD=1180 XHG=1051 YBD=1134 YHG=1104>water. " XBD=1292 XHG=1231 YBD=1133 YHG=1102>An" XBD=278 XHG=123 YBD=1176 YHG=1145>effective " XBD=389 XHG=301 YBD=1177 YHG=1146>dose " XBD=576 XHG=410 YBD=1185 YHG=1146>requires " XBD=700 XHG=597 YBD=1186 YHG=1146>large " XBD=892 XHG=721 YBD=1178 YHG=1147>volumes " XBD=954 XHG=914 YBD=1177 YHG=1147>of " XBD=1164 XHG=975 YBD=1184 YHG=1147>solution ; " XBD=1291 XHG=1201 YBD=1178 YHG=1147>thus" XBD=155 XHG=122 YBD=1220 YHG=1189>in " XBD=273 XHG=172 YBD=1221 YHG=1190>order " XBD=331 XHG=291 YBD=1220 YHG=1192>to " XBD=574 XHG=352 YBD=1221 YHG=1189>administer " XBD=613 XHG=597 YBD=1221 YHG=1193>1 " XBD=669 XHG=634 YBD=1230 YHG=1200>g. " XBD=731 XHG=691 YBD=1221 YHG=1190>of " XBD=1063 XHG=749 YBD=1230 YHG=1191>sulphanilamide " XBD=1201 XHG=1083 YBD=1222 YHG=1192>about " XBD=1291 XHG=1225 YBD=1222 YHG=1191>125" XBD=215 XHG=123 YBD=1264 YHG=1242>c.cm. " XBD=274 XHG=236 YBD=1264 YHG=1233>of " XBD=358 XHG=293 YBD=1264 YHG=1234>the " XBD=544 XHG=379 YBD=1266 YHG=1233>solution " XBD=667 XHG=565 YBD=1265 YHG=1236>must " XBD=736 XHG=688 YBD=1265 YHG=1234>be " XBD=878 XHG=755 YBD=1274 YHG=1235>given. " XBD=1008 XHG=930 YBD=1265 YHG=1235>The " XBD=1177 XHG=1030 YBD=1266 YHG=1235>sodium " XBD=1290 XHG=1199 YBD=1266 YHG=1235>salts" XBD=155 XHG=123 YBD=1307 YHG=1277>of " XBD=485 XHG=172 YBD=1317 YHG=1277>sulphapyridine, " XBD=807 XHG=508 YBD=1318 YHG=1278>sulphathiazole " XBD=904 XHG=828 YBD=1309 YHG=1279>and " XBD=1207 XHG=925 YBD=1318 YHG=1278>sulphadiazine " XBD=1291 XHG=1227 YBD=1310 YHG=1288>are" XBD=211 XHG=121 YBD=1352 YHG=1330>more " XBD=383 XHG=232 YBD=1358 YHG=1321>soluble, " XBD=477 XHG=407 YBD=1353 YHG=1322>but " XBD=600 XHG=500 YBD=1353 YHG=1322>their " XBD=789 XHG=621 YBD=1354 YHG=1324>extreme " XBD=1011 XHG=811 YBD=1362 YHG=1322>alkalinity " XBD=1162 XHG=1033 YBD=1353 YHG=1323>makes " XBD=1290 XHG=1184 YBD=1354 YHG=1323>them" XBD=154 XHG=122 YBD=1396 YHG=1374>so " XBD=350 XHG=168 YBD=1406 YHG=1364>irritating " XBD=452 XHG=364 YBD=1397 YHG=1366>that " XBD=561 XHG=468 YBD=1406 YHG=1367>they " XBD=642 XHG=577 YBD=1397 YHG=1368>too " XBD=765 XHG=663 YBD=1397 YHG=1368>must " XBD=829 XHG=781 YBD=1397 YHG=1367>be " XBD=975 XHG=843 YBD=1407 YHG=1366>highly " XBD=1136 XHG=992 YBD=1397 YHG=1366>diluted " XBD=1181 XHG=1152 YBD=1397 YHG=1366>if " XBD=1290 XHG=1196 YBD=1406 YHG=1367>they" XBD=175 XHG=121 YBD=1441 YHG=1418>are " XBD=231 XHG=192 YBD=1440 YHG=1411>to " XBD=297 XHG=251 YBD=1441 YHG=1409>be " XBD=478 XHG=313 YBD=1450 YHG=1409>injected " XBD=576 XHG=495 YBD=1442 YHG=1411>into " XBD=874 XHG=595 YBD=1442 YHG=1411>subcutaneous " XBD=1040 XHG=891 YBD=1442 YHG=1411>tissues. " XBD=1288 XHG=1093 YBD=1450 YHG=1411>Recently," XBD=288 XHG=120 YBD=1491 YHG=1454>however, " XBD=420 XHG=314 YBD=1486 YHG=1454>there " XBD=521 XHG=452 YBD=1486 YHG=1455>has " XBD=646 XHG=550 YBD=1487 YHG=1455>been " XBD=694 XHG=672 YBD=1486 YHG=1465>a " XBD=909 XHG=720 YBD=1494 YHG=1455>tendency " XBD=975 XHG=934 YBD=1486 YHG=1457>to " XBD=1126 XHG=1000 YBD=1486 YHG=1456>revert " XBD=1196 XHG=1155 YBD=1485 YHG=1457>to " XBD=1289 XHG=1222 YBD=1486 YHG=1456>the" XBD=382 XHG=121 YBD=1530 YHG=1497>subcutaneous " XBD=542 XHG=420 YBD=1535 YHG=1501>route, " XBD=829 XHG=581 YBD=1539 YHG=1499>particularly " XBD=907 XHG=867 YBD=1530 YHG=1509>as " XBD=969 XHG=947 YBD=1530 YHG=1509>a " XBD=1289 XHG=1005 YBD=1538 YHG=1500>postoperative" XBD=286 XHG=121 YBD=1578 YHG=1551>measure, " XBD=412 XHG=303 YBD=1583 YHG=1542>using " XBD=451 XHG=428 YBD=1574 YHG=1552>a " XBD=561 XHG=467 YBD=1583 YHG=1553>very " XBD=697 XHG=578 YBD=1574 YHG=1543>dilute " XBD=890 XHG=714 YBD=1574 YHG=1543>solution. " XBD=1032 XHG=942 YBD=1574 YHG=1543>This " XBD=1204 XHG=1049 YBD=1574 YHG=1543>method " XBD=1289 XHG=1220 YBD=1574 YHG=1543>has" XBD=195 XHG=120 YBD=1617 YHG=1595>now " XBD=308 XHG=216 YBD=1617 YHG=1586>been " XBD=586 XHG=331 YBD=1628 YHG=1586>investigated " XBD=649 XHG=609 YBD=1618 YHG=1588>in " XBD=744 XHG=677 YBD=1619 YHG=1589>160 " XBD=870 XHG=768 YBD=1618 YHG=1596>cases " XBD=949 XHG=894 YBD=1627 YHG=1587>by " XBD=1107 XHG=972 YBD=1626 YHG=1586>Taplin " XBD=1208 XHG=1131 YBD=1618 YHG=1588>and " XBD=1289 XHG=1229 YBD=1618 YHG=1587>his" XBD=339 XHG=120 YBD=1670 YHG=1629>colleagues,4 " XBD=436 XHG=360 YBD=1662 YHG=1632>and " XBD=498 XHG=458 YBD=1662 YHG=1632>in " XBD=568 XHG=526 YBD=1662 YHG=1633>19 " XBD=695 XHG=593 YBD=1663 YHG=1641>cases " XBD=1133 XHG=718 YBD=1662 YHG=1631>blood-concentration " XBD=1289 XHG=1157 YBD=1662 YHG=1640>curves" XBD=205 XHG=119 YBD=1705 YHG=1674>have " XBD=308 XHG=217 YBD=1706 YHG=1675>been " XBD=494 XHG=321 YBD=1707 YHG=1675>followed " XBD=558 XHG=507 YBD=1714 YHG=1685>up " XBD=632 XHG=572 YBD=1706 YHG=1676>for " XBD=763 XHG=646 YBD=1706 YHG=1677>50-70 " XBD=887 XHG=772 YBD=1706 YHG=1675>hours " XBD=999 XHG=901 YBD=1706 YHG=1675>after " XBD=1077 XHG=1011 YBD=1706 YHG=1675>the " XBD=1214 XHG=1090 YBD=1706 YHG=1675>initial " XBD=1288 XHG=1223 YBD=1706 YHG=1675>ad-" XBD=371 XHG=121 YBD=1750 YHG=1718>ministration. " XBD=478 XHG=399 YBD=1750 YHG=1719>The " XBD=675 XHG=491 YBD=1750 YHG=1719>solutions " XBD=808 XHG=688 YBD=1750 YHG=1719>found " XBD=921 XHG=822 YBD=1750 YHG=1721>most " XBD=1059 XHG=935 YBD=1750 YHG=1719>useful " XBD=1165 XHG=1069 YBD=1750 YHG=1729>were " XBD=1290 XHG=1179 YBD=1750 YHG=1719>made" XBD=164 XHG=118 YBD=1803 YHG=1762>by " XBD=313 XHG=178 YBD=1803 YHG=1762>adding " XBD=378 XHG=338 YBD=1794 YHG=1765>to " XBD=497 XHG=405 YBD=1794 YHG=1765>1000 " XBD=622 XHG=512 YBD=1794 YHG=1773>c.cm. " XBD=679 XHG=640 YBD=1794 YHG=1763>of " XBD=829 XHG=704 YBD=1794 YHG=1764>sterile " XBD=1001 XHG=854 YBD=1794 YHG=1764>normal " XBD=1141 XHG=1025 YBD=1794 YHG=1763>saline " XBD=1236 XHG=1169 YBD=1794 YHG=1765>5-7 " XBD=1288 XHG=1253 YBD=1803 YHG=1772>g." XBD=153 XHG=120 YBD=1838 YHG=1807>of " XBD=317 XHG=175 YBD=1838 YHG=1807>sodium " XBD=672 XHG=345 YBD=1847 YHG=1806>sulphapyridine; " XBD=805 XHG=699 YBD=1838 YHG=1809>7-5-8 " XBD=867 XHG=832 YBD=1847 YHG=1817>g. " XBD=936 XHG=896 YBD=1838 YHG=1808>of " XBD=1111 XHG=963 YBD=1838 YHG=1807>sodium " XBD=1289 XHG=1139 YBD=1847 YHG=1807>sulpha-" XBD=276 XHG=119 YBD=1888 YHG=1851>thiazole, " XBD=333 XHG=292 YBD=1882 YHG=1861>or " XBD=368 XHG=347 YBD=1882 YHG=1853>5 " XBD=414 XHG=379 YBD=1891 YHG=1861>g. " XBD=469 XHG=431 YBD=1882 YHG=1852>of " XBD=631 XHG=482 YBD=1882 YHG=1851>sodium " XBD=939 XHG=645 YBD=1891 YHG=1851>sulphadiazine. " XBD=1069 XHG=990 YBD=1881 YHG=1851>The " XBD=1145 XHG=1081 YBD=1891 YHG=1851>pH " XBD=1292 XHG=1160 YBD=1882 YHG=1851>values" XBD=153 XHG=120 YBD=1926 YHG=1895>of " XBD=262 XHG=163 YBD=1926 YHG=1895>these " XBD=456 XHG=274 YBD=1926 YHG=1895>solutions " XBD=566 XHG=468 YBD=1926 YHG=1904>were " XBD=697 XHG=578 YBD=1926 YHG=1895>about " XBD=804 XHG=712 YBD=1931 YHG=1897>10-0, |>" XBD=878 XHG=821 YBD=1926 YHG=1896>9-5 " XBD=965 XHG=890 YBD=1926 YHG=1895>and " XBD=1048 XHG=978 YBD=1931 YHG=1896>9-2, " XBD=1130 XHG=1059 YBD=1926 YHG=1895>but " XBD=1180 XHG=1140 YBD=1926 YHG=1895>in " XBD=1291 XHG=1193 YBD=1934 YHG=1895>spite" XBD=155 XHG=120 YBD=1971 YHG=1939>of " XBD=258 XHG=165 YBD=1970 YHG=1939>their " XBD=430 XHG=274 YBD=1970 YHG=1939>decided " XBD=648 XHG=446 YBD=1979 YHG=1939>alkalinity " XBD=756 XHG=663 YBD=1979 YHG=1939>they " XBD=911 XHG=772 YBD=1970 YHG=1939>caused " XBD=976 XHG=927 YBD=1970 YHG=1949>no " XBD=1090 XHG=992 YBD=1971 YHG=1939>local " XBD=1291 XHG=1104 YBD=1970 YHG=1939>reactions" XBD=214 XHG=118 YBD=2015 YHG=1981>when " XBD=413 XHG=248 YBD=2022 YHG=1983>injected " XBD=572 XHG=450 YBD=2014 YHG=1983>under " XBD=674 XHG=608 YBD=2014 YHG=1983>the " XBD=808 XHG=712 YBD=2014 YHG=1983>skin. " XBD=938 XHG=858 YBD=2014 YHG=1983>The " XBD=1158 XHG=975 YBD=2014 YHG=1983>solutions " XBD=1292 XHG=1194 YBD=2014 YHG=1991>were" XBD=268 XHG=118 YBD=2068 YHG=2027>injected " XBD=362 XHG=282 YBD=2058 YHG=2027>into " XBD=474 XHG=377 YBD=2058 YHG=2027>both " XBD=616 XHG=488 YBD=2067 YHG=2027>thighs " XBD=683 XHG=631 YBD=2067 YHG=2027>by " XBD=925 XHG=698 YBD=2058 YHG=2027>continuous " XBD=1023 XHG=940 YBD=2067 YHG=2027>drip " XBD=1128 XHG=1038 YBD=2058 YHG=2037>over " XBD=1292 XHG=1141 YBD=2067 YHG=2026>periods" XBD=152 XHG=119 YBD=2103 YHG=2072>of " XBD=282 XHG=187 YBD=2103 YHG=2072>from " XBD=391 XHG=316 YBD=2103 YHG=2073>two " XBD=467 XHG=425 YBD=2102 YHG=2073>to " XBD=577 XHG=501 YBD=2102 YHG=2071>five " XBD=802 XHG=615 YBD=2102 YHG=2071>hours-a " XBD=1040 XHG=834 YBD=2111 YHG=2070>procedure " XBD=1292 XHG=1077 YBD=2102 YHG=2070>sometimes" XBD=224 XHG=118 YBD=2148 YHG=2115>called " XBD=605 XHG=248 YBD=2157 YHG=2115>hypodermoclysis. " XBD=760 XHG=671 YBD=2146 YHG=2115>This " XBD=910 XHG=784 YBD=2147 YHG=2116>would " XBD=1027 XHG=938 YBD=2155 YHG=2116>only " XBD=1104 XHG=1056 YBD=2147 YHG=2116>be " XBD=1292 XHG=1129 YBD=2155 YHG=2114>possible" XBD=150 XHG=118 YBD=2192 YHG=2160>in |>" XBD=293 XHG=176 YBD=2192 YHG=2160>adult " XBD=474 XHG=305 YBD=2200 YHG=2159>patients " XBD=597 XHG=502 YBD=2191 YHG=2159>with " XBD=649 XHG=626 YBD=2190 YHG=2168>a " XBD=901 XHG=675 YBD=2199 YHG=2159>reasonably " XBD=1028 XHG=929 YBD=2199 YHG=2160>good " XBD=1290 XHG=1057 YBD=2191 YHG=2159>circulation." XBD=227 XHG=119 YBD=2237 YHG=2204>When " XBD=551 XHG=241 YBD=2243 YHG=2203>sulphapyridine " XBD=642 XHG=564 YBD=2234 YHG=2213>was " XBD=857 XHG=657 YBD=2243 YHG=2203>employed " XBD=938 XHG=871 YBD=2234 YHG=2204>the " XBD=1163 XHG=953 YBD=2234 YHG=2204>maximum " XBD=1292 XHG=1177 YBD=2235 YHG=2203>blood" XBD=387 XHG=119 YBD=2279 YHG=2247>concentration " XBD=481 XHG=404 YBD=2278 YHG=2257>was " XBD=660 XHG=499 YBD=2278 YHG=2247>reached " XBD=735 XHG=677 YBD=2278 YHG=2247>six " XBD=866 XHG=751 YBD=2278 YHG=2248>hours " XBD=981 XHG=883 YBD=2278 YHG=2247>after " XBD=1064 XHG=998 YBD=2278 YHG=2247>the " XBD=1163 XHG=1080 YBD=2278 YHG=2247>first " XBD=1292 XHG=1180 YBD=2286 YHG=2247>clysis" XBD=184 XHG=117 YBD=2325 YHG=2301>was " XBD=374 XHG=207 YBD=2329 YHG=2291>started ; " XBD=494 XHG=400 YBD=2322 YHG=2291>with " XBD=820 XHG=520 YBD=2330 YHG=2291>sulphathiazole " XBD=911 XHG=844 YBD=2322 YHG=2290>the " XBD=1033 XHG=934 YBD=2331 YHG=2291>peak " XBD=1126 XHG=1049 YBD=2323 YHG=2298>was " XBD=1193 XHG=1152 YBD=2322 YHG=2292>at " XBD=1292 XHG=1218 YBD=2322 YHG=2291>five" XBD=153 XHG=118 YBD=2368 YHG=2338>to " XBD=273 XHG=176 YBD=2376 YHG=2336>eight " XBD=416 XHG=290 YBD=2371 YHG=2336>hours, " XBD=512 XHG=435 YBD=2366 YHG=2335>and " XBD=627 XHG=532 YBD=2366 YHG=2335>with " XBD=932 XHG=649 YBD=2375 YHG=2334>sulphadiazine " XBD=998 XHG=958 YBD=2366 YHG=2337>at " XBD=1104 XHG=1017 YBD=2366 YHG=2335>four " XBD=1170 XHG=1128 YBD=2366 YHG=2336>to " XBD=1292 XHG=1188 YBD=2376 YHG=2335>eight" XBD=230 XHG=117 YBD=2411 YHG=2379>hours. " XBD=358 XHG=280 YBD=2410 YHG=2379>The " XBD=572 XHG=389 YBD=2409 YHG=2379>maximal " XBD=732 XHG=602 YBD=2410 YHG=2379>values " XBD=922 XHG=761 YBD=2410 YHG=2379>reached " XBD=1104 XHG=953 YBD=2410 YHG=2379>showed " XBD=1292 XHG=1134 YBD=2410 YHG=2378>decided" XBD=325 XHG=114 YBD=2459 YHG=2423>variations, " XBD=443 XHG=344 YBD=2453 YHG=2424>from " XBD=583 XHG=463 YBD=2453 YHG=2423>about " XBD=626 XHG=604 YBD=2453 YHG=2424>4 " XBD=685 XHG=644 YBD=2453 YHG=2424>to " XBD=825 XHG=705 YBD=2453 YHG=2422>about " XBD=891 XHG=848 YBD=2453 YHG=2424>16 " XBD=986 XHG=911 YBD=2463 YHG=2433>mg. " XBD=1073 XHG=1006 YBD=2463 YHG=2433>per " XBD=1163 XHG=1097 YBD=2454 YHG=2425>100 " XBD=1290 XHG=1183 YBD=2453 YHG=2432>c.cm." XBD=213 XHG=119 YBD=2506 YHG=2467>They " XBD=338 XHG=231 YBD=2502 YHG=2474>were, " XBD=406 XHG=357 YBD=2497 YHG=2476>on " XBD=490 XHG=423 YBD=2497 YHG=2466>the " XBD=647 XHG=510 YBD=2503 YHG=2466>whole, " XBD=795 XHG=663 YBD=2497 YHG=2466>lowest " XBD=871 XHG=811 YBD=2497 YHG=2467>for " XBD=1193 XHG=892 YBD=2506 YHG=2466>sulphathiazole " XBD=1291 XHG=1214 YBD=2497 YHG=2466>and" XBD=254 XHG=118 YBD=2551 YHG=2510>highest " XBD=329 XHG=270 YBD=2541 YHG=2511>for " XBD=686 XHG=346 YBD=2549 YHG=2510>sulphadiazine, a " XBD=849 XHG=704 YBD=2550 YHG=2510>finding " XBD=907 XHG=866 YBD=2540 YHG=2511>to " XBD=973 XHG=926 YBD=2540 YHG=2510>be " XBD=1176 XHG=991 YBD=2549 YHG=2510>expected " XBD=1291 XHG=1192 YBD=2540 YHG=2510>from" XBD=175 XHG=118 YBD=2586 YHG=2555>the " XBD=333 XHG=199 YBD=2585 YHG=2554>known " XBD=459 XHG=356 YBD=2584 YHG=2556>rates " XBD=524 XHG=485 YBD=2584 YHG=2554>of " XBD=772 XHG=551 YBD=2593 YHG=2553>absorption " XBD=875 XHG=799 YBD=2584 YHG=2553>and " XBD=1094 XHG=902 YBD=2585 YHG=2554>excretion " XBD=1159 XHG=1120 YBD=2584 YHG=2554>of " XBD=1291 XHG=1185 YBD=2584 YHG=2554>these" XBD=182 XHG=117 YBD=2630 YHG=2593>two " XBD=318 XHG=196 YBD=2637 YHG=2598>drugs. " XBD=415 XHG=369 YBD=2628 YHG=2598>In " XBD=540 XHG=430 YBD=2629 YHG=2598>order " XBD=593 XHG=552 YBD=2628 YHG=2599>to " XBD=767 XHG=607 YBD=2637 YHG=2599>prevent " XBD=846 XHG=779 YBD=2628 YHG=2597>the " XBD=973 XHG=858 YBD=2628 YHG=2596>blood " XBD=1290 XHG=986 YBD=2628 YHG=2598>concentrations" XBD=203 XHG=116 YBD=2673 YHG=2641>from " XBD=347 XHG=218 YBD=2681 YHG=2641>falling " XBD=404 XHG=363 YBD=2673 YHG=2643>to " XBD=445 XHG=423 YBD=2672 YHG=2651>a " XBD=715 XHG=463 YBD=2681 YHG=2641>dangerously " XBD=803 XHG=730 YBD=2673 YHG=2641>low " XBD=930 XHG=821 YBD=2678 YHG=2633>level, " XBD=978 XHG=947 YBD=2672 YHG=2641>it " XBD=1071 XHG=993 YBD=2672 YHG=2650>was " XBD=1291 XHG=1093 YBD=2681 YHG=2650>necessary" XBD=151 XHG=117 YBD=2716 YHG=2686>to " XBD=298 XHG=173 YBD=2725 YHG=2688>repeat " XBD=388 XHG=322 YBD=2716 YHG=2686>the " XBD=525 XHG=413 YBD=2725 YHG=2685>clysis " XBD=618 XHG=550 YBD=2716 YHG=2687>not " XBD=740 XHG=642 YBD=2717 YHG=2685>later " XBD=858 XHG=762 YBD=2716 YHG=2685>than " XBD=1029 XHG=883 YBD=2716 YHG=2685>sixteen " XBD=1167 XHG=1052 YBD=2716 YHG=2685>hours " XBD=1291 XHG=1192 YBD=2716 YHG=2686>after" XBD=174 XHG=117 YBD=2760 YHG=2729>the " XBD=266 XHG=188 YBD=2760 YHG=2729>first " XBD=563 XHG=283 YBD=2760 YHG=2729>subcutaneous " XBD=670 XHG=581 YBD=2760 YHG=2729>dose " XBD=726 XHG=685 YBD=2760 YHG=2729>in " XBD=808 XHG=741 YBD=2760 YHG=2729>the " XBD=908 XHG=824 YBD=2760 YHG=2739>case " XBD=965 XHG=925 YBD=2759 YHG=2729>of " XBD=1290 XHG=979 YBD=2769 YHG=2729>sulphapyridine" XBD=183 XHG=117 YBD=2803 YHG=2772>and " XBD=508 XHG=199 YBD=2812 YHG=2773>sulphathiazole, " XBD=605 XHG=527 YBD=2804 YHG=2773>and " XBD=720 XHG=621 YBD=2804 YHG=2773>after " XBD=855 XHG=737 YBD=2804 YHG=2773>about " XBD=1019 XHG=872 YBD=2813 YHG=2773>twenty " XBD=1150 XHG=1035 YBD=2804 YHG=2773>hours " XBD=1206 XHG=1166 YBD=2803 YHG=2773>in " XBD=1289 XHG=1223 YBD=2803 YHG=2773>the" XBD=190 XHG=117 YBD=2847 YHG=2825>case " XBD=255 XHG=218 YBD=2846 YHG=2817>of " XBD=578 XHG=283 YBD=2856 YHG=2816>sulphadiazine. " XBD=750 XHG=643 YBD=2848 YHG=2817>Since " XBD=844 XHG=778 YBD=2847 YHG=2816>the " XBD=1288 XHG=872 YBD=2847 YHG=2816>blood-concentration" XBD=233 XHG=115 YBD=2890 YHG=2859>values " XBD=321 XHG=259 YBD=2890 YHG=2869>are " XBD=415 XHG=346 YBD=2891 YHG=2862>not " XBD=688 XHG=442 YBD=2900 YHG=2860>predictable, " XBD=747 XHG=715 YBD=2891 YHG=2860>it " XBD=805 XHG=773 YBD=2891 YHG=2860>is " XBD=996 XHG=832 YBD=2899 YHG=2860>thought " XBD=1220 XHG=1022 YBD=2899 YHG=2869>necessary " XBD=1286 XHG=1246 YBD=2890 YHG=2861>to" XBD=277 XHG=115 YBD=2933 YHG=2903>estimate " XBD=403 XHG=297 YBD=2934 YHG=2903>them " XBD=596 XHG=424 YBD=2935 YHG=2904>between " XBD=702 XHG=616 YBD=2934 YHG=2904>four " XBD=800 XHG=724 YBD=2934 YHG=2904>and " XBD=923 XHG=821 YBD=2943 YHG=2904>eight " XBD=1058 XHG=944 YBD=2934 YHG=2904>hours " XBD=1156 XHG=1079 YBD=2934 YHG=2903>and " XBD=1288 XHG=1177 YBD=2942 YHG=2901>again" XBD=271 XHG=116 YBD=2977 YHG=2943>between " XBD=459 XHG=285 YBD=2978 YHG=2946>fourteen " XBD=552 XHG=475 YBD=2978 YHG=2948>and " XBD=740 XHG=567 YBD=2987 YHG=2948>eighteen " XBD=870 XHG=755 YBD=2979 YHG=2948>hours " XBD=983 XHG=885 YBD=2977 YHG=2947>after " XBD=1204 XHG=996 YBD=2977 YHG=2948>treatment " XBD=1288 XHG=1218 YBD=2977 YHG=2947>has" XBD=198 XHG=115 YBD=3019 YHG=2987>been " XBD=378 XHG=222 YBD=3021 YHG=2990>started. " XBD=519 XHG=429 YBD=3022 YHG=2990>This " XBD=673 XHG=543 YBD=3024 YHG=2992>makes " XBD=762 XHG=695 YBD=3022 YHG=2992>the " XBD=943 XHG=786 YBD=3024 YHG=2990>method " XBD=1094 XHG=965 YBD=3021 YHG=2990>rather " XBD=1286 XHG=1117 YBD=3021 YHG=2990>cumber-" XBD=218 XHG=116 YBD=3069 YHG=3039>some, " XBD=315 XHG=240 YBD=3065 YHG=3034>and " XBD=392 XHG=333 YBD=3064 YHG=3034>for " XBD=562 XHG=411 YBD=3066 YHG=3035>routine " XBD=686 XHG=581 YBD=3066 YHG=3035>work " XBD=737 XHG=705 YBD=3065 YHG=3036>it " XBD=897 XHG=756 YBD=3065 YHG=3036>cannot " XBD=1090 XHG=917 YBD=3073 YHG=3036>compete " XBD=1202 XHG=1108 YBD=3066 YHG=3034>with " XBD=1286 XHG=1221 YBD=3064 YHG=3034>the" XBD=186 XHG=116 YBD=3106 YHG=3075>oral " XBD=380 XHG=214 YBD=3113 YHG=3077>method, " XBD=478 XHG=407 YBD=3108 YHG=3077>but " XBD=541 XHG=509 YBD=3109 YHG=3078>it " XBD=694 XHG=572 YBD=3118 YHG=3078>might " XBD=888 XHG=725 YBD=3118 YHG=3078>usefully " XBD=960 XHG=913 YBD=3108 YHG=3078>be " XBD=1203 XHG=990 YBD=3118 YHG=3078>employed, " XBD=1287 XHG=1228 YBD=3107 YHG=3078>for" XBD=285 XHG=115 YBD=3159 YHG=3120>example, " XBD=412 XHG=303 YBD=3151 YHG=3121>when " XBD=496 XHG=430 YBD=3152 YHG=3122>the " XBD=663 XHG=512 YBD=3161 YHG=3122>patient " XBD=821 XHG=681 YBD=3153 YHG=3124>cannot " XBD=880 XHG=840 YBD=3152 YHG=3132>or " XBD=972 XHG=896 YBD=3152 YHG=3121>will " XBD=1057 XHG=988 YBD=3152 YHG=3123>not " XBD=1285 XHG=1073 YBD=3160 YHG=3122>cooperate," XBD=225 XHG=114 YBD=3193 YHG=3161>where " XBD=345 XHG=241 YBD=3194 YHG=3164>there " XBD=393 XHG=361 YBD=3194 YHG=3164>is " XBD=614 XHG=410 YBD=3203 YHG=3165>persistent " XBD=830 XHG=632 YBD=3205 YHG=3166>vomiting, " XBD=925 XHG=849 YBD=3195 YHG=3165>and " XBD=1041 XHG=944 YBD=3195 YHG=3164>after " XBD=1284 XHG=1058 YBD=3204 YHG=3164>operations," XBD=345 XHG=114 YBD=3246 YHG=3205>particularly " XBD=598 XHG=381 YBD=3246 YHG=3208>operations " XBD=685 XHG=637 YBD=3238 YHG=3218>on " XBD=790 XHG=724 YBD=3239 YHG=3208>the " XBD=975 XHG=830 YBD=3238 YHG=3209>mouth. " XBD=1060 XHG=1025 YBD=3239 YHG=3208>A " XBD=1288 XHG=1100 YBD=3247 YHG=3207>potential

1. Sehwentker, F. F., Gelman, S. and Long, P. H. J. Amer. med.Ass. 1937, 108, 953; Eldahl, A. Lancet, 1938, i, 712; Willien,L. J. J. Amer. med. Ass. 1938, 110, 630; Crawford, T. andFleming, G. B. Lancet, 1938, i, 987.

2. Proom, H. Lancet, 1937, i, 16. 3. Banks, H. S. Ibid, 1938, ii, 7.4. Taplin, G. V., Custer, E. A. and Young, L. E. J. Amer. med. Ass.

1943, 121, 313. See Lancet, 1942. ii, 192.

" XBD=1502 XHG=1360 YBD=246 YHG=207>danger " XBD=1550 XHG=1518 YBD=237 YHG=206>is " XBD=1640 XHG=1575 YBD=237 YHG=206>the " XBD=1883 XHG=1656 YBD=246 YHG=206>production " XBD=1942 XHG=1903 YBD=237 YHG=206>of " XBD=2112 XHG=1965 YBD=236 YHG=206>oedema " XBD=2169 XHG=2130 YBD=237 YHG=207>of " XBD=2252 XHG=2186 YBD=237 YHG=206>the " XBD=2396 XHG=2273 YBD=246 YHG=206>lungs, " XBD=2497 XHG=2420 YBD=236 YHG=205>and " XBD=2554 XHG=2514 YBD=237 YHG=206>in" XBD=1409 XHG=1358 YBD=281 YHG=250>its " XBD=1591 XHG=1437 YBD=289 YHG=251>present " XBD=1719 XHG=1619 YBD=282 YHG=251>form " XBD=1815 XHG=1749 YBD=280 YHG=249>the |>" XBD=2007 XHG=1846 YBD=280 YHG=248>method " XBD=2165 XHG=2029 YBD=280 YHG=249>should " XBD=2260 XHG=2191 YBD=280 YHG=251>not " XBD=2478 XHG=2290 YBD=281 YHG=250>therefore " XBD=2555 XHG=2505 YBD=280 YHG=249>be" XBD=1513 XHG=1359 YBD=333 YHG=294>applied " XBD=1569 XHG=1529 YBD=324 YHG=293>in " XBD=1828 XHG=1586 YBD=333 YHG=293>pneumonia." XBD=1528 XHG=1410 YBD=368 YHG=337>Other " XBD=1656 XHG=1544 YBD=368 YHG=338>novel " XBD=1797 XHG=1669 YBD=368 YHG=339>routes " XBD=1852 XHG=1813 YBD=368 YHG=337>of " XBD=2174 XHG=1867 YBD=368 YHG=336>administration " XBD=2228 XHG=2189 YBD=367 YHG=337>of " XBD=2552 XHG=2243 YBD=376 YHG=336>sulphonamides" XBD=1423 XHG=1359 YBD=412 YHG=390>are " XBD=1546 XHG=1461 YBD=412 YHG=391>now " XBD=1696 XHG=1584 YBD=421 YHG=381>being " XBD=1933 XHG=1732 YBD=421 YHG=381>proposed, " XBD=2163 XHG=1971 YBD=420 YHG=380>following " XBD=2250 XHG=2201 YBD=411 YHG=390>on " XBD=2355 XHG=2288 YBD=411 YHG=380>the " XBD=2553 XHG=2393 YBD=411 YHG=381>method" XBD=1568 XHG=1359 YBD=464 YHG=424>developed " XBD=1633 XHG=1581 YBD=464 YHG=425>by " XBD=1852 XHG=1648 YBD=456 YHG=424>Chambers " XBD=1942 XHG=1866 YBD=455 YHG=425>and " XBD=2014 XHG=1955 YBD=456 YHG=424>his associates " XBD=2329 XHG=2243 YBD=454 YHG=423>5 for " XBD=2553 XHG=2341 YBD=463 YHG=424>producing" XBD=1383 XHG=1362 YBD=480 YHG=468>&dquo; " XBD=1694 XHG=1400 YBD=507 YHG=468>micro-crystals " XBD=1731 XHG=1711 YBD=482 YHG=470>&dquo; " XBD=1791 XHG=1751 YBD=499 YHG=469>of " XBD=1871 XHG=1804 YBD=499 YHG=469>the " XBD=2012 XHG=1887 YBD=508 YHG=469>drugs. " XBD=2094 XHG=2056 YBD=499 YHG=468>It " XBD=2141 XHG=2109 YBD=499 YHG=468>is " XBD=2320 XHG=2155 YBD=507 YHG=467>possible " XBD=2376 XHG=2336 YBD=498 YHG=469>to " XBD=2552 XHG=2392 YBD=507 YHG=476>prepare" XBD=1381 XHG=1358 YBD=542 YHG=521>a " XBD=1536 XHG=1401 YBD=547 YHG=510>stable, " XBD=1718 XHG=1557 YBD=547 YHG=511>neutral, " XBD=1906 XHG=1739 YBD=551 YHG=521>aqueous " XBD=2159 XHG=1926 YBD=552 YHG=512>suspension, " XBD=2407 XHG=2179 YBD=551 YHG=511>resembling " XBD=2552 XHG=2426 YBD=542 YHG=520>cream" XBD=1399 XHG=1359 YBD=585 YHG=554>of " XBD=1606 XHG=1414 YBD=594 YHG=555>magnesia " XBD=1660 XHG=1621 YBD=585 YHG=555>in " XBD=1847 XHG=1674 YBD=595 YHG=554>physical " XBD=2081 XHG=1860 YBD=596 YHG=556>properties, " XBD=2221 XHG=2097 YBD=587 YHG=555>which " XBD=2307 XHG=2236 YBD=586 YHG=565>can " XBD=2370 XHG=2323 YBD=586 YHG=555>be " XBD=2552 XHG=2383 YBD=594 YHG=555>injected" XBD=1525 XHG=1357 YBD=638 YHG=598>through " XBD=1641 XHG=1566 YBD=629 YHG=598>fine " XBD=1927 XHG=1682 YBD=638 YHG=599>hypodermic " XBD=2130 XHG=1968 YBD=636 YHG=600>needles, " XBD=2318 XHG=2172 YBD=640 YHG=600>poured " XBD=2442 XHG=2359 YBD=630 YHG=599>into " XBD=2552 XHG=2484 YBD=629 YHG=598>the" XBD=1570 XHG=1356 YBD=673 YHG=642>interstices " XBD=1624 XHG=1585 YBD=673 YHG=642>of " XBD=1806 XHG=1636 YBD=679 YHG=643>wounds, " XBD=1864 XHG=1822 YBD=673 YHG=652>or " XBD=2040 XHG=1878 YBD=683 YHG=644>sprayed " XBD=2094 XHG=2053 YBD=675 YHG=645>to " XBD=2207 XHG=2108 YBD=675 YHG=644>form " XBD=2245 XHG=2223 YBD=674 YHG=653>a " XBD=2551 XHG=2260 YBD=683 YHG=642>sulphonamide" XBD=1501 XHG=1361 YBD=726 YHG=686>&dquo;fog&dquo; " XBD=1579 XHG=1539 YBD=717 YHG=686>in " XBD=1682 XHG=1615 YBD=717 YHG=686>the " XBD=1785 XHG=1718 YBD=717 YHG=686>air. " XBD=1940 XHG=1837 YBD=718 YHG=686>Thus " XBD=2108 XHG=1978 YBD=718 YHG=687>Harris " XBD=2222 XHG=2144 YBD=718 YHG=688>and others " XBD=2551 XHG=2402 YBD=718 YHG=687>6 have" XBD=1629 XHG=1357 YBD=761 YHG=729>administered " XBD=1686 XHG=1663 YBD=761 YHG=739>a " XBD=2018 XHG=1720 YBD=770 YHG=730>sulphathiazole " XBD=2141 XHG=2051 YBD=762 YHG=731>mist " XBD=2227 XHG=2175 YBD=771 YHG=731>by " XBD=2474 XHG=2261 YBD=762 YHG=731>inhalation " XBD=2549 XHG=2508 YBD=762 YHG=732>to" XBD=1524 XHG=1357 YBD=805 YHG=774>infected " XBD=1641 XHG=1546 YBD=805 YHG=774>mice " XBD=1739 XHG=1662 YBD=804 YHG=774>and " XBD=1941 XHG=1760 YBD=805 YHG=774>obtained " XBD=2199 XHG=1961 YBD=815 YHG=775>therapeutic " XBD=2356 XHG=2219 YBD=807 YHG=775>results " XBD=2550 XHG=2378 YBD=815 YHG=785>compar-" XBD=1442 XHG=1357 YBD=849 YHG=818>able " XBD=1574 XHG=1479 YBD=849 YHG=814>with " XBD=1720 XHG=1611 YBD=848 YHG=818>those " XBD=1940 XHG=1760 YBD=849 YHG=818>obtained " XBD=2069 XHG=1976 YBD=850 YHG=819>with " XBD=2188 XHG=2108 YBD=849 YHG=819>oral " XBD=2548 XHG=2225 YBD=850 YHG=819>administration." XBD=1610 XHG=1359 YBD=901 YHG=861>Satisfactory " XBD=1762 XHG=1648 YBD=892 YHG=862>blood " XBD=1913 XHG=1798 YBD=893 YHG=862>levels " XBD=2046 XHG=1950 YBD=893 YHG=871>were " XBD=2201 XHG=2083 YBD=901 YHG=862>easily " XBD=2433 XHG=2239 YBD=899 YHG=863>obtained, " XBD=2550 XHG=2473 YBD=893 YHG=862>and" XBD=1580 XHG=1357 YBD=945 YHG=906>absorption " XBD=1682 XHG=1604 YBD=937 YHG=912>was " XBD=1926 XHG=1707 YBD=937 YHG=905>considered " XBD=1991 XHG=1951 YBD=937 YHG=908>to " XBD=2064 XHG=2018 YBD=937 YHG=906>be " XBD=2187 XHG=2088 YBD=936 YHG=906>from " XBD=2279 XHG=2213 YBD=937 YHG=906>the " XBD=2395 XHG=2304 YBD=946 YHG=907>lung " XBD=2551 XHG=2420 YBD=938 YHG=907>rather" XBD=1454 XHG=1356 YBD=981 YHG=950>than " XBD=1574 XHG=1473 YBD=981 YHG=949>from " XBD=1662 XHG=1595 YBD=981 YHG=949>the " XBD=1868 XHG=1683 YBD=987 YHG=950>stomach, " XBD=1991 XHG=1891 YBD=981 YHG=950>since " XBD=2105 XHG=2013 YBD=989 YHG=959>very " XBD=2199 XHG=2126 YBD=981 YHG=950>low " XBD=2399 XHG=2220 YBD=981 YHG=952>amounts " XBD=2461 XHG=2422 YBD=981 YHG=950>of " XBD=2549 XHG=2482 YBD=981 YHG=951>the" XBD=1454 XHG=1357 YBD=1034 YHG=995>drug " XBD=1578 XHG=1480 YBD=1025 YHG=1003>were " XBD=1831 XHG=1611 YBD=1026 YHG=994>afterwards " XBD=1983 XHG=1864 YBD=1026 YHG=994>found " XBD=2051 XHG=2013 YBD=1026 YHG=995>in " XBD=2147 XHG=2080 YBD=1025 YHG=994>the " XBD=2297 XHG=2175 YBD=1035 YHG=994>lungs. " XBD=2445 XHG=2364 YBD=1026 YHG=994>The " XBD=2550 XHG=2478 YBD=1034 YHG=995>dry" XBD=1635 XHG=1357 YBD=1079 YHG=1038>microcrystals " XBD=1767 XHG=1668 YBD=1070 YHG=1039>have " XBD=1888 XHG=1809 YBD=1070 YHG=1039>also " XBD=2027 XHG=1932 YBD=1070 YHG=1039>been |>" XBD=2281 XHG=2064 YBD=1070 YHG=1038>insumated " XBD=2401 XHG=2320 YBD=1070 YHG=1039>into " XBD=2551 XHG=2441 YBD=1070 YHG=1040>nasal" XBD=1433 XHG=1356 YBD=1114 YHG=1083>and " XBD=1548 XHG=1467 YBD=1114 YHG=1083>oral " XBD=1737 XHG=1580 YBD=1114 YHG=1083>cavities " XBD=1879 XHG=1776 YBD=1114 YHG=1088>as 11 " XBD=2061 XHG=1895 YBD=1114 YHG=1082>smoke.&dquo; " XBD=2279 XHG=2112 YBD=1113 YHG=1082>Arnett has " XBD=2548 XHG=2426 YBD=1115 YHG=1083>incor-" XBD=1517 XHG=1355 YBD=1166 YHG=1127>porated |>" XBD=1606 XHG=1548 YBD=1158 YHG=1128>0-3 " XBD=1677 XHG=1635 YBD=1166 YHG=1137>g. " XBD=1740 XHG=1701 YBD=1157 YHG=1127>of " XBD=2051 XHG=1769 YBD=1166 YHG=1117>sulphadiazine " XBD=2118 XHG=2079 YBD=1157 YHG=1127>in " XBD=2171 XHG=2147 YBD=1157 YHG=1136>a " XBD=2290 XHG=2198 YBD=1166 YHG=1127>plug " XBD=2358 XHG=2314 YBD=1158 YHG=1128>of " XBD=2548 XHG=2385 YBD=1166 YHG=1127>paraffin" XBD=1453 XHG=1354 YBD=1206 YHG=1181>wax, " XBD=1554 XHG=1477 YBD=1201 YHG=1171>and " XBD=1694 XHG=1577 YBD=1201 YHG=1171>noted " XBD=1783 XHG=1717 YBD=1202 YHG=1171>the " XBD=1970 XHG=1805 YBD=1210 YHG=1171>salivary " XBD=2277 XHG=1993 YBD=1210 YHG=1171>sulphadiazine " XBD=2415 XHG=2299 YBD=1201 YHG=1171>levels " XBD=2478 XHG=2438 YBD=1202 YHG=1171>in " XBD=2546 XHG=2505 YBD=1201 YHG=1173>11" XBD=1524 XHG=1355 YBD=1254 YHG=1215>subjects " XBD=1629 XHG=1545 YBD=1246 YHG=1215>who " XBD=1744 XHG=1652 YBD=1245 YHG=1215>used " XBD=1843 XHG=1767 YBD=1245 YHG=1215>this " XBD=1905 XHG=1865 YBD=1245 YHG=1224>as " XBD=1950 XHG=1928 YBD=1245 YHG=1224>a " XBD=2259 XHG=1972 YBD=1254 YHG=1214>chewing-gum. " XBD=2363 XHG=2310 YBD=1245 YHG=1214>At " XBD=2452 XHG=2384 YBD=1245 YHG=1215>the " XBD=2549 XHG=2474 YBD=1245 YHG=1215>end" XBD=1394 XHG=1355 YBD=1289 YHG=1260>of " XBD=1487 XHG=1412 YBD=1290 YHG=1261>two " XBD=1621 XHG=1506 YBD=1289 YHG=1259>hours " XBD=1705 XHG=1640 YBD=1289 YHG=1259>the " XBD=1837 XHG=1722 YBD=1289 YHG=1259>levels " XBD=1950 XHG=1855 YBD=1289 YHG=1268>were " XBD=2087 XHG=1970 YBD=1289 YHG=1258>33-96 " XBD=2180 XHG=2106 YBD=1298 YHG=1267>mg. " XBD=2267 XHG=2199 YBD=1297 YHG=1267>per " XBD=2356 XHG=2289 YBD=1289 YHG=1259>100 " XBD=2484 XHG=2374 YBD=1289 YHG=1267>c.cm. " XBD=2547 XHG=2504 YBD=1289 YHG=1258>of" XBD=1486 XHG=1354 YBD=1338 YHG=1303>saliva, " XBD=1548 XHG=1506 YBD=1333 YHG=1304>at " XBD=1631 XHG=1565 YBD=1333 YHG=1303>the " XBD=1722 XHG=1649 YBD=1333 YHG=1303>end " XBD=1780 XHG=1740 YBD=1333 YHG=1302>of " XBD=1902 XHG=1796 YBD=1332 YHG=1303>three " XBD=2033 XHG=1919 YBD=1332 YHG=1302>hours " XBD=2143 XHG=2051 YBD=1341 YHG=1302>they " XBD=2349 XHG=2162 YBD=1342 YHG=1302>averaged |>" XBD=2451 XHG=2369 YBD=1332 YHG=1303>56-7 " XBD=2546 XHG=2470 YBD=1341 YHG=1311>mg." XBD=1431 XHG=1354 YBD=1377 YHG=1347>and " XBD=1496 XHG=1455 YBD=1377 YHG=1347>at " XBD=1586 XHG=1519 YBD=1377 YHG=1346>the " XBD=1682 XHG=1608 YBD=1376 YHG=1346>end " XBD=1745 XHG=1706 YBD=1376 YHG=1346>of " XBD=1853 XHG=1766 YBD=1376 YHG=1346>four " XBD=1988 XHG=1873 YBD=1376 YHG=1346>hours " XBD=2130 XHG=2013 YBD=1376 YHG=1346>20-25 " XBD=2228 XHG=2154 YBD=1385 YHG=1355>mg. " XBD=2320 XHG=2252 YBD=1385 YHG=1354>per " XBD=2414 XHG=2346 YBD=1376 YHG=1347>100 " XBD=2546 XHG=2438 YBD=1376 YHG=1355>c.cm." XBD=1414 XHG=1356 YBD=1421 YHG=1390>On " XBD=1509 XHG=1431 YBD=1421 YHG=1390>this " XBD=1627 XHG=1527 YBD=1421 YHG=1389>basis " XBD=1692 XHG=1645 YBD=1420 YHG=1390>he " XBD=1899 XHG=1710 YBD=1420 YHG=1389>considers " XBD=1939 XHG=1917 YBD=1420 YHG=1399>a " XBD=2045 XHG=1957 YBD=1420 YHG=1389>trial " XBD=2101 XHG=2062 YBD=1419 YHG=1389>of " XBD=2184 XHG=2118 YBD=1420 YHG=1389>the " XBD=2359 XHG=2202 YBD=1420 YHG=1389>method " XBD=2548 XHG=2376 YBD=1429 YHG=1389>justified" XBD=1393 XHG=1353 YBD=1465 YHG=1435>in " XBD=1626 XHG=1421 YBD=1470 YHG=1434>tonsillitis, " XBD=1892 XHG=1654 YBD=1474 YHG=1433>pharyngitis " XBD=1996 XHG=1920 YBD=1464 YHG=1434>and " XBD=2089 XHG=2023 YBD=1464 YHG=1434>the " XBD=2201 XHG=2114 YBD=1464 YHG=1433>like. " XBD=2343 XHG=2253 YBD=1464 YHG=1433>Two " XBD=2413 XHG=2371 YBD=1463 YHG=1443>or " XBD=2547 XHG=2440 YBD=1464 YHG=1434>three" XBD=1475 XHG=1353 YBD=1509 YHG=1479>chews " XBD=1559 XHG=1490 YBD=1518 YHG=1487>per " XBD=1719 XHG=1574 YBD=1508 YHG=1478>minute " XBD=1798 XHG=1735 YBD=1508 YHG=1487>are " XBD=2105 XHG=1814 YBD=1513 YHG=1477>sufficient,-and " XBD=2187 XHG=2120 YBD=1508 YHG=1477>the " XBD=2378 XHG=2203 YBD=1508 YHG=1476>material " XBD=2484 XHG=2394 YBD=1517 YHG=1487>may " XBD=2547 XHG=2499 YBD=1508 YHG=1477>be" XBD=1421 XHG=1351 YBD=1553 YHG=1522>left " XBD=1476 XHG=1436 YBD=1552 YHG=1522>in " XBD=1559 XHG=1492 YBD=1552 YHG=1522>the " XBD=1709 XHG=1575 YBD=1552 YHG=1522>mouth " XBD=1960 XHG=1724 YBD=1561 YHG=1521>throughout " XBD=2042 XHG=1975 YBD=1551 YHG=1521>the " XBD=2178 XHG=2057 YBD=1561 YHG=1521>night, " XBD=2253 XHG=2195 YBD=1551 YHG=1521>for " XBD=2300 XHG=2268 YBD=1551 YHG=1521>it " XBD=2347 XHG=2316 YBD=1552 YHG=1520>is " XBD=2547 XHG=2362 YBD=1552 YHG=1521>harmless" XBD=1378 XHG=1341 YBD=1604 YHG=1566>if " XBD=1620 XHG=1397 YBD=1597 YHG=1565>swallowed.

BEST USE OF AMPUTATION STUMP

" XBD=1488 XHG=1402 YBD=1714 YHG=1684>THE " XBD=1596 XHG=1509 YBD=1715 YHG=1684>idea " XBD=1654 XHG=1614 YBD=1714 YHG=1683>of " XBD=1892 XHG=1671 YBD=1723 YHG=1683>harnessing " XBD=1976 XHG=1911 YBD=1714 YHG=1683>the " XBD=2154 XHG=1996 YBD=1714 YHG=1683>muscles " XBD=2214 XHG=2175 YBD=1713 YHG=1683>of " XBD=2282 XHG=2233 YBD=1714 YHG=1692>an " XBD=2546 XHG=2302 YBD=1722 YHG=1682>amputation" XBD=1483 XHG=1353 YBD=1767 YHG=1730>stump " XBD=1545 XHG=1503 YBD=1758 YHG=1729>to " XBD=1788 XHG=1565 YBD=1767 YHG=1727>implement " XBD=1857 XHG=1808 YBD=1758 YHG=1736>an " XBD=2050 XHG=1876 YBD=1758 YHG=1727>artificial " XBD=2160 XHG=2067 YBD=1758 YHG=1727>limb " XBD=2287 XHG=2181 YBD=1758 YHG=1736>came " XBD=2347 XHG=2306 YBD=1757 YHG=1728>to " XBD=2545 XHG=2369 YBD=1758 YHG=1726>Giuliano" XBD=1573 XHG=1354 YBD=1811 YHG=1772>Vanghette " XBD=1628 XHG=1588 YBD=1802 YHG=1772>of " XBD=1765 XHG=1650 YBD=1802 YHG=1771>Turin " XBD=1924 XHG=1789 YBD=1811 YHG=1771>during " XBD=2256 XHG=1945 YBD=1811 YHG=1771>the Abyssinian " XBD=2481 XHG=2279 YBD=1811 YHG=1771>campaign " XBD=2544 XHG=2504 YBD=1802 YHG=1771>of" XBD=1462 XHG=1358 YBD=1846 YHG=1817>1896. " XBD=1585 XHG=1515 YBD=1846 YHG=1815>His " XBD=1835 XHG=1601 YBD=1846 YHG=1815>enthusiasm " XBD=1928 XHG=1850 YBD=1846 YHG=1825>was " XBD=2091 XHG=1944 YBD=1856 YHG=1816>greater " XBD=2201 XHG=2106 YBD=1846 YHG=1815>than " XBD=2275 XHG=2217 YBD=1846 YHG=1815>his " XBD=2546 XHG=2293 YBD=1854 YHG=1815>opportunity" XBD=1426 XHG=1354 YBD=1890 YHG=1860>but " XBD=1507 XHG=1447 YBD=1890 YHG=1859>his " XBD=1653 XHG=1528 YBD=1890 YHG=1859>fellow " XBD=1942 XHG=1676 YBD=1899 YHG=1861>countryman, " XBD=2067 XHG=1965 YBD=1890 YHG=1859>Prof. " XBD=2137 XHG=2092 YBD=1891 YHG=1859>V. " XBD=2271 XHG=2162 YBD=1890 YHG=1859>Putti " XBD=2334 XHG=2295 YBD=1890 YHG=1859>of " XBD=2542 XHG=2357 YBD=1899 YHG=1859>Bologna," XBD=1507 XHG=1354 YBD=1934 YHG=1903>worked " XBD=1579 XHG=1537 YBD=1934 YHG=1905>at " XBD=1711 XHG=1607 YBD=1934 YHG=1903>what " XBD=1788 XHG=1739 YBD=1934 YHG=1903>he " XBD=1937 XHG=1817 YBD=1934 YHG=1903>called " XBD=2276 XHG=1965 YBD=1934 YHG=1903>kinematisation " XBD=2445 XHG=2307 YBD=1943 YHG=1903>during " XBD=2541 XHG=2473 YBD=1934 YHG=1903>the" XBD=1432 XHG=1353 YBD=1978 YHG=1957>war " XBD=1499 XHG=1459 YBD=1978 YHG=1948>of " XBD=1691 XHG=1529 YBD=1978 YHG=1949>1915-18 " XBD=1796 XHG=1719 YBD=1978 YHG=1947>and addressed " XBD=2144 XHG=2039 YBD=1978 YHG=1947>the " XBD=2298 XHG=2174 YBD=1987 YHG=1947>Royal " XBD=2478 XHG=2326 YBD=1987 YHG=1947>Society " XBD=2545 XHG=2506 YBD=1978 YHG=1947>of" XBD=1540 XHG=1355 YBD=2022 YHG=1991>Medicine " XBD=1626 XHG=1578 YBD=2022 YHG=2001>on " XBD=1721 XHG=1662 YBD=2025 YHG=1991>his " XBD=1904 XHG=1756 YBD=2023 YHG=1991>results. " XBD=2085 XHG=1955 YBD=2022 YHG=1991>About " XBD=2198 XHG=2122 YBD=2022 YHG=1989>the " XBD=2330 XHG=2225 YBD=2023 YHG=2001>same " XBD=2461 XHG=2365 YBD=2022 YHG=1991>time " XBD=2541 XHG=2497 YBD=2023 YHG=1992>F." XBD=1594 XHG=1356 YBD=2067 YHG=2035>Sauerbruch " XBD=1801 XHG=1607 YBD=2076 YHG=2035>perfected " XBD=1839 XHG=1816 YBD=2066 YHG=2045>a " XBD=2055 XHG=1853 YBD=2076 YHG=2036>technique " XBD=2110 XHG=2071 YBD=2067 YHG=2036>of " XBD=2183 XHG=2123 YBD=2066 YHG=2036>his " XBD=2281 XHG=2197 YBD=2067 YHG=2045>own " XBD=2336 XHG=2295 YBD=2066 YHG=2036>in " XBD=2545 XHG=2352 YBD=2075 YHG=2035>Germany" XBD=1432 XHG=1354 YBD=2110 YHG=2079>and " XBD=1587 XHG=1447 YBD=2112 YHG=2079>Tuffier reported " XBD=1860 XHG=1792 YBD=2111 YHG=2079>9 to " XBD=1943 XHG=1877 YBD=2111 YHG=2080>the " XBD=2064 XHG=1958 YBD=2111 YHG=2080>Paris " XBD=2275 XHG=2079 YBD=2120 YHG=2079>Academy " XBD=2331 XHG=2290 YBD=2111 YHG=2080>of " XBD=2623 XHG=2345 YBD=2115 YHG=2079>Medicine." XBD=1402 XHG=1356 YBD=2155 YHG=2123>In " XBD=1510 XHG=1433 YBD=2155 YHG=2123>this " XBD=1704 XHG=1542 YBD=2163 YHG=2126>country " XBD=1838 XHG=1735 YBD=2156 YHG=2134>some " XBD=1915 XHG=1871 YBD=2155 YHG=2125>30 " XBD=2039 XHG=1947 YBD=2155 YHG=2124>such " XBD=2286 XHG=2070 YBD=2164 YHG=2124>operations " XBD=2414 XHG=2317 YBD=2155 YHG=2133>were " XBD=2545 XHG=2439 YBD=2163 YHG=2124>done" XBD=1408 XHG=1354 YBD=2208 YHG=2168>by " XBD=1567 XHG=1427 YBD=2199 YHG=2168>Pearce " XBD=1723 XHG=1588 YBD=2204 YHG=2168>Gould, " XBD=2126 XHG=1744 YBD=2208 YHG=2167>Fitzmaurice-Kelly " XBD=2222 XHG=2146 YBD=2199 YHG=2168>and " XBD=2382 XHG=2243 YBD=2199 YHG=2168>others. " XBD=2545 XHG=2434 YBD=2199 YHG=2156>After" XBD=1463 XHG=1359 YBD=2248 YHG=2213>1921, " XBD=1562 XHG=1495 YBD=2243 YHG=2212>the " XBD=1748 XHG=1592 YBD=2243 YHG=2212>method " XBD=1842 XHG=1777 YBD=2243 YHG=2212>fell " XBD=1952 XHG=1871 YBD=2243 YHG=2212>into " XBD=2107 XHG=1983 YBD=2243 YHG=2212>disuse " XBD=2177 XHG=2137 YBD=2242 YHG=2212>in " XBD=2274 XHG=2207 YBD=2243 YHG=2213>the " XBD=2368 XHG=2305 YBD=2242 YHG=2212>old " XBD=2542 XHG=2397 YBD=2249 YHG=2212>world ;" XBD=1427 XHG=1355 YBD=2286 YHG=2255>but " XBD=1477 XHG=1437 YBD=2287 YHG=2256>in " XBD=1511 XHG=1488 YBD=2286 YHG=2265>a " XBD=1621 XHG=1521 YBD=2287 YHG=2256>little " XBD=1770 XHG=1631 YBD=2287 YHG=2255>book 10 " XBD=1861 XHG=1781 YBD=2296 YHG=2256>just " XBD=2073 XHG=1873 YBD=2295 YHG=2256>published " XBD=2222 XHG=2088 YBD=2286 YHG=2255>Nissen " XBD=2313 XHG=2236 YBD=2287 YHG=2256>and " XBD=2545 XHG=2327 YBD=2296 YHG=2255>Bergmann" XBD=1461 XHG=1356 YBD=2331 YHG=2299>show " XBD=1562 XHG=1474 YBD=2331 YHG=2300>that " XBD=1680 XHG=1576 YBD=2332 YHG=2308>some " XBD=1849 XHG=1692 YBD=2332 YHG=2300>interest " XBD=1931 XHG=1862 YBD=2331 YHG=2300>has " XBD=2040 XHG=1945 YBD=2331 YHG=2300>been " XBD=2288 XHG=2054 YBD=2331 YHG=2299>maintained " XBD=2342 XHG=2302 YBD=2330 YHG=2299>in " XBD=2543 XHG=2355 YBD=2331 YHG=2299>America." XBD=1436 XHG=1356 YBD=2375 YHG=2344>The " XBD=1654 XHG=1458 YBD=2384 YHG=2343>principle; " XBD=1717 XHG=1678 YBD=2375 YHG=2344>in " XBD=1847 XHG=1741 YBD=2375 YHG=2344>these " XBD=2098 XHG=1872 YBD=2384 YHG=2344>operations, " XBD=2154 XHG=2122 YBD=2375 YHG=2343>is " XBD=2220 XHG=2178 YBD=2375 YHG=2344>to " XBD=2298 XHG=2244 YBD=2375 YHG=2343>fix " XBD=2387 XHG=2322 YBD=2375 YHG=2344>the " XBD=2543 XHG=2412 YBD=2384 YHG=2345>stump" XBD=1515 XHG=1356 YBD=2419 YHG=2387>muscles " XBD=1588 XHG=1535 YBD=2427 YHG=2387>by " XBD=1742 XHG=1605 YBD=2428 YHG=2388>plastic " XBD=1915 XHG=1762 YBD=2427 YHG=2397>surgery " XBD=1973 XHG=1934 YBD=2418 YHG=2387>in " XBD=2085 XHG=1992 YBD=2418 YHG=2388>such " XBD=2128 XHG=2105 YBD=2418 YHG=2397>a " XBD=2232 XHG=2145 YBD=2428 YHG=2397>way " XBD=2339 XHG=2250 YBD=2418 YHG=2388>that " XBD=2452 XHG=2358 YBD=2427 YHG=2387>they " XBD=2544 XHG=2472 YBD=2419 YHG=2397>can" XBD=1403 XHG=1355 YBD=2463 YHG=2431>be " XBD=1527 XHG=1433 YBD=2462 YHG=2431>used " XBD=1599 XHG=1559 YBD=2462 YHG=2433>to " XBD=1799 XHG=1630 YBD=2465 YHG=2432>activate " XBD=1879 XHG=1829 YBD=2461 YHG=2441>an " XBD=2083 XHG=1910 YBD=2462 YHG=2431>artificial " XBD=2205 XHG=2112 YBD=2462 YHG=2431>limb " XBD=2279 XHG=2237 YBD=2462 YHG=2441>or " XBD=2545 XHG=2310 YBD=2462 YHG=2431>mechanical" XBD=1470 XHG=1354 YBD=2506 YHG=2475>hand. " XBD=1625 XHG=1522 YBD=2506 YHG=2475>Thus " XBD=1713 XHG=1648 YBD=2506 YHG=2475>the " XBD=1835 XHG=1736 YBD=2505 YHG=2483>arms " XBD=1922 XHG=1858 YBD=2505 YHG=2483>are " XBD=2121 XHG=1945 YBD=2515 YHG=2474>designed " XBD=2185 XHG=2143 YBD=2506 YHG=2476>to " XBD=2386 XHG=2207 YBD=2506 YHG=2475>transmit " XBD=2543 XHG=2409 YBD=2516 YHG=2475>finger-" XBD=1431 XHG=1354 YBD=2549 YHG=2518>and " XBD=1693 XHG=1455 YBD=2558 YHG=2518>thumb-grip " XBD=1759 XHG=1717 YBD=2549 YHG=2514>to " XBD=1850 XHG=1783 YBD=2549 YHG=2518>the " XBD=2003 XHG=1872 YBD=2556 YHG=2518>hand ; " XBD=2118 XHG=2042 YBD=2549 YHG=2518>and " XBD=2209 XHG=2142 YBD=2549 YHG=2518>the " XBD=2333 XHG=2233 YBD=2550 YHG=2519>clear " XBD=2442 XHG=2356 YBD=2549 YHG=2520>text " XBD=2544 XHG=2467 YBD=2550 YHG=2514>and" XBD=1543 XHG=1354 YBD=2593 YHG=2561>beautiful " XBD=1811 XHG=1563 YBD=2592 YHG=2562>illustrations " XBD=1872 XHG=1832 YBD=2592 YHG=2561>in " XBD=1970 XHG=1894 YBD=2593 YHG=2562>this " XBD=2094 XHG=1992 YBD=2592 YHG=2561>book " XBD=2220 XHG=2116 YBD=2593 YHG=2561>show " XBD=2327 XHG=2240 YBD=2594 YHG=2563>how " XBD=2379 XHG=2348 YBD=2593 YHG=2562>it " XBD=2473 XHG=2402 YBD=2593 YHG=2572>can " XBD=2543 XHG=2495 YBD=2593 YHG=2563>be" XBD=1463 XHG=1354 YBD=2636 YHG=2605>done. " XBD=1594 XHG=1515 YBD=2636 YHG=2605>But " XBD=1644 XHG=1612 YBD=2636 YHG=2605>it " XBD=1766 XHG=1664 YBD=2636 YHG=2607>must " XBD=1832 XHG=1785 YBD=2636 YHG=2605>be " XBD=1967 XHG=1852 YBD=2636 YHG=2605>borne " XBD=2026 XHG=1986 YBD=2635 YHG=2606>in " XBD=2150 XHG=2045 YBD=2636 YHG=2605>mind " XBD=2256 XHG=2169 YBD=2636 YHG=2606>that " XBD=2299 XHG=2276 YBD=2636 YHG=2616>a " XBD=2399 XHG=2317 YBD=2646 YHG=2606>pull " XBD=2544 XHG=2416 YBD=2646 YHG=2616>power" XBD=1395 XHG=1355 YBD=2680 YHG=2650>of " XBD=1467 XHG=1421 YBD=2680 YHG=2650>24 " XBD=1545 XHG=1491 YBD=2680 YHG=2649>lb. " XBD=1780 XHG=1573 YBD=2688 YHG=2648>developed " XBD=1847 XHG=1805 YBD=2680 YHG=2650>at " XBD=1939 XHG=1872 YBD=2680 YHG=2649>the " XBD=2060 XHG=1962 YBD=2680 YHG=2649>level " XBD=2125 XHG=2086 YBD=2680 YHG=2649>of " XBD=2291 XHG=2150 YBD=2681 YHG=2650>muscle " XBD=2543 XHG=2317 YBD=2682 YHG=2650>transfixion" XBD=1528 XHG=1354 YBD=2724 YHG=2693>becomes " XBD=1644 XHG=1555 YBD=2732 YHG=2693>only " XBD=1789 XHG=1669 YBD=2723 YHG=2693>about " XBD=1837 XHG=1816 YBD=2724 YHG=2694>6 " XBD=1913 XHG=1861 YBD=2724 YHG=2693>lb. " XBD=1981 XHG=1940 YBD=2723 YHG=2694>at " XBD=2072 XHG=2007 YBD=2724 YHG=2693>the " XBD=2214 XHG=2097 YBD=2730 YHG=2693>hand, " XBD=2318 XHG=2241 YBD=2725 YHG=2694>and " XBD=2440 XHG=2344 YBD=2725 YHG=2703>even " XBD=2543 XHG=2465 YBD=2725 YHG=2694>this" XBD=1495 XHG=1353 YBD=2768 YHG=2738>cannot " XBD=1568 XHG=1521 YBD=2767 YHG=2736>be " XBD=1800 XHG=1594 YBD=2767 YHG=2736>sustained. " XBD=1966 XHG=1853 YBD=2772 YHG=2736>Thus, " XBD=2035 XHG=1994 YBD=2767 YHG=2745>as " XBD=2196 XHG=2062 YBD=2768 YHG=2737>Nissen " XBD=2300 XHG=2223 YBD=2768 YHG=2738>and " XBD=2543 XHG=2326 YBD=2778 YHG=2738>Bergmann" XBD=1473 XHG=1353 YBD=2820 YHG=2789>agree, " XBD=1588 XHG=1497 YBD=2819 YHG=2780>only " XBD=1704 XHG=1607 YBD=2819 YHG=2779>light " XBD=1971 XHG=1726 YBD=2819 YHG=2780>occupations " XBD=2055 XHG=1992 YBD=2811 YHG=2789>are " XBD=2175 XHG=2077 YBD=2821 YHG=2790>open " XBD=2236 XHG=2195 YBD=2812 YHG=2783>to " XBD=2351 XHG=2259 YBD=2812 YHG=2782>such " XBD=2542 XHG=2372 YBD=2820 YHG=2781>patients" XBD=1429 XHG=1352 YBD=2854 YHG=2824>and " XBD=1512 XHG=1446 YBD=2854 YHG=2823>the " XBD=1727 XHG=1531 YBD=2862 YHG=2823>operation " XBD=1970 XHG=1746 YBD=2854 YHG=2823>determines " XBD=2027 XHG=1987 YBD=2854 YHG=2824>in " XBD=2216 XHG=2045 YBD=2856 YHG=2824>advance " XBD=2299 XHG=2232 YBD=2856 YHG=2825>the " XBD=2542 XHG=2315 YBD=2855 YHG=2824>limitations" XBD=1392 XHG=1351 YBD=2897 YHG=2868>to " XBD=1535 XHG=1411 YBD=2898 YHG=2866>which " XBD=1601 XHG=1553 YBD=2897 YHG=2866>he " XBD=1695 XHG=1619 YBD=2897 YHG=2866>will " XBD=1761 XHG=1713 YBD=2897 YHG=2866>be " XBD=1987 XHG=1779 YBD=2907 YHG=2866>subjected." XBD=1447 XHG=1400 YBD=2940 YHG=2911>In " XBD=1551 XHG=1473 YBD=2940 YHG=2909>this " XBD=1741 XHG=1579 YBD=2948 YHG=2911>country " XBD=1959 XHG=1767 YBD=2941 YHG=2910>attention " XBD=2054 XHG=1984 YBD=2941 YHG=2911>has " XBD=2177 XHG=2081 YBD=2942 YHG=2911>been " XBD=2373 XHG=2205 YBD=2941 YHG=2911>directed " XBD=2472 XHG=2399 YBD=2940 YHG=2910>less " XBD=2540 XHG=2498 YBD=2940 YHG=2912>to" XBD=1489 XHG=1350 YBD=2993 YHG=2953>plastic " XBD=1675 XHG=1519 YBD=2993 YHG=2962>surgery " XBD=1799 XHG=1704 YBD=2983 YHG=2953>than " XBD=1870 XHG=1828 YBD=2983 YHG=2954>to " XBD=1966 XHG=1900 YBD=2985 YHG=2953>the " XBD=2126 XHG=1996 YBD=2993 YHG=2954>design " XBD=2234 XHG=2157 YBD=2984 YHG=2954>and " XBD=2473 XHG=2262 YBD=2993 YHG=2953>perfection " XBD=2588 XHG=2504 YBD=2982 YHG=2953>of" XBD=1581 XHG=1350 YBD=3036 YHG=2997>appliances, " XBD=1800 XHG=1606 YBD=3028 YHG=2995>activated " XBD=1863 XHG=1823 YBD=3027 YHG=2996>in " XBD=1990 XHG=1887 YBD=3028 YHG=3006>some " XBD=2115 XHG=2014 YBD=3028 YHG=3001>cases " XBD=2237 XHG=2138 YBD=3027 YHG=2997>from " XBD=2328 XHG=2261 YBD=3026 YHG=2996>the " XBD=2540 XHG=2351 YBD=3026 YHG=2996>shoulder." XBD=1468 XHG=1349 YBD=3071 YHG=3040>These " XBD=1598 XHG=1485 YBD=3070 YHG=3039>limbs " XBD=1688 XHG=1617 YBD=3070 YHG=3049>can " XBD=1915 XHG=1705 YBD=3071 YHG=3040>undertake " XBD=1983 XHG=1934 YBD=3071 YHG=3041>all " XBD=2067 XHG=2000 YBD=3071 YHG=3041>the " XBD=2334 XHG=2085 YBD=3075 YHG=3041>movements, " XBD=2449 XHG=2353 YBD=3075 YHG=3039>both " XBD=2542 XHG=2467 YBD=3069 YHG=3039>fine" XBD=1428 XHG=1351 YBD=3115 YHG=3084>and " XBD=1588 XHG=1446 YBD=3119 YHG=3092>coarse, " XBD=1789 XHG=1606 YBD=3123 YHG=3083>achieved " XBD=1859 XHG=1805 YBD=3123 YHG=3084>by " XBD=1943 XHG=1876 YBD=3115 YHG=3083>the " XBD=2193 XHG=1961 YBD=3114 YHG=3082>mechanical " XBD=2327 XHG=2210 YBD=3118 YHG=3083>hand, " XBD=2425 XHG=2348 YBD=3112 YHG=3082>and " XBD=2542 XHG=2442 YBD=3113 YHG=3082>have" XBD=1374 XHG=1351 YBD=3157 YHG=3136>a " XBD=1519 XHG=1402 YBD=3158 YHG=3127>wider " XBD=1665 XHG=1549 YBD=3166 YHG=3136>range " XBD=1734 XHG=1694 YBD=3158 YHG=3127>of " XBD=1929 XHG=1763 YBD=3164 YHG=3128>service ; " XBD=2063 XHG=1973 YBD=3157 YHG=3127>thus " XBD=2262 XHG=2091 YBD=3164 YHG=3125>patients " XBD=2363 XHG=2292 YBD=3155 YHG=3134>can " XBD=2436 XHG=2394 YBD=3156 YHG=3127>at " XBD=2542 XHG=2465 YBD=3156 YHG=3125>will" XBD=1494 XHG=1349 YBD=3210 YHG=3170>change " XBD=1610 XHG=1510 YBD=3211 YHG=3170>from " XBD=1725 XHG=1628 YBD=3210 YHG=3170>light " XBD=1891 XHG=1744 YBD=3201 YHG=3170>clerical " XBD=2012 XHG=1907 YBD=3201 YHG=3169>work " XBD=2070 XHG=2030 YBD=3199 YHG=3171>to " XBD=2215 XHG=2089 YBD=3207 YHG=3169>heavy " XBD=2389 XHG=2234 YBD=3198 YHG=3168>manual " XBD=2542 XHG=2407 YBD=3199 YHG=3168>labour" XBD=1512 XHG=1348 YBD=3244 YHG=3212>without " XBD=1694 XHG=1534 YBD=3253 YHG=3208>needing " XBD=1738 XHG=1716 YBD=3243 YHG=3223>a " XBD=1860 XHG=1759 YBD=3244 YHG=3213>fresh " XBD=2078 XHG=1883 YBD=3252 YHG=3212>operation " XBD=2142 XHG=2100 YBD=3241 YHG=3221>or " XBD=2186 XHG=2163 YBD=3242 YHG=3221>a " XBD=2351 XHG=2208 YBD=3250 YHG=3211>change " XBD=2413 XHG=2374 YBD=3242 YHG=3213>of " XBD=2539 XHG=2433 YBD=3242 YHG=3212>limb.

5. Chambers, L. A. et al. Amer. med. Ass. 1942, 119, 324.6. Harris, T. N. et al. Amer. J. med. Sci. 1943, 205. 1.7. Arnett, J. H. Ibid, 1943, 205, 6.8. Lancet. 1918, i, 791. 9. Ibid, 1920, i, 281.

10. Nissen, R. and Bergmann, E. Cineplastic Operations on Stumpsof the Upper Extremity. (Heinemann. Pp. 88. 17s. 6d.)