The Journal of

Steroid Biochemistry & Molecular Biology Editors -in -chief

J. R. PASQUALINI and R. SCHOLLER

VOLUME CONTENTS, SUBJECT AND AUTHOR INDEX

V o l u m e 48 1994

( ~ Pergamon

The Journal of Steroid Biochemistry and Molecular Biology

E D I T O R S - I N - C H I E F J. R. Pasqua l in i and R. Schol ler

Foundation for Hormone Research, 26 Boulevard Brune, 75014 Paris, France

H. Adlercreutz, Helsinki, Finland M. Beato, Marburg/Lahn, Germany B. Groner, Freiburg, Germany E. Gurpide, New York, U.S.A. J.-A. Gustafsson, Huddinge, Sweden E. V. Jensen, Hamburg, Germany J. Kato, Yamanashi-ken, Japan

A S S O C I A T E E D I T O R S

R. J. B. K i n g , Gui ld ford , Eng l a nd M. E. L i p p m a n , Wash ing ton , D C , U.S .A. L. M a r t i n i , Mi lan , I taly A. M u n c k , Hanover , N H , U.S .A. B. W. O ' M a l l e y , Hous ton , T X , U.S .A. D. O. T o f t , Rochester , M N , U.S .A.

A. Aakvaag, Bergen, Norway A. S. Bhatnagar, Basel, Switzerland R. Bouillon, Leuven, Belgium A. Brodie, Baltimore, U.S.A. M. L. Casey, Dallas, U.S.A. K. J. Catt, Bethesda, U.S.A. J. A. Cidlowski, Chapel Hill, U.S.A. P. D. Darbre, Reading, England G. Daxenbichler, Innsbruck, Austria E. R, DeSombre, Chicago, U.S.A. B. N. Diaz-Chico, Las Palmas, Spain R. B. Dickson, Washington, U.S.A. M. Dowsett, London, England M. L. Dufau, Bethesda, U.S.A. D. P. Edwards, Denver, U.S.A. H. A. Eriksson, Stockholm, Sweden A. N. Fejes-Toth, Hanover, U.S.A. K. Fotherby, London, England J. W. Funder, Prahran, Australia G. Greene, Chicago, U.S.A. H. Gronemeyer, Strasbourg, France H. Honjo, Kyoto, Japan

CORRESPONDING EDITORS K. B. Horwitz, Denver, U.S.A. I. Huhtaniemi, Turku, Finland V. H. T. James, London, England V. C. Jordan, Chicago, U.S.A. B. S. Katzenellenbogen, Urbana, U,S.A. A. M. Kaye, Rehovot, Israel E. R. de Kloet, Leiden, The Netherlands L. Kloosterboer, Oss, The Netherlands F. Labrie, Quebec, Canada S. Liao, Chicago, U.S.A. V. B. Mahesh, Augusta, U.S.A, B. S. McEwen, New York, U.S.A. H. Michna, Berlin, Germany E. Milgrom, Le Kremlin-Bic&re, France W. R. Miller, Edinburgh, Scotland J. Mfiller, Zurich, Switzerland B. E. P. Murphy, Montreal, Canada L. J. Murphy, Winnipeg, Canada M. I. New, New York, U.S.A. A. W. Norman, Riverside, U.S.A. T. Ojasoo, Montrouge, France M. J. Parker, London, England

G. P6rez-Palacios, Mexico City, Mexico W. B. Pratt, Ann Arbor, U.S.A. J. P. Raynaud, Paris, France R. Renkawitz, Giessen, Germany H. Rochefort, Montpellier, France G. Rousseau, Brussels, Belgium B. Sato, Osaka City, Japan M. Serio, Florence, Italy E. R. Simpson, Dallas, U.S.A. J. Sj6vall, Stockholm, Sweden L. StgLrka, Prague, Czech Republic J. F. Strauss III, Philadelphia, U.S.A. R. L. Sutherland, Darlinghurst, Australia J. R. Tara, London, England W. Taylor, Tynemouth, England P. Tuohimaa, Tampere, Finland G. Verhoeven, Leuven, Belgium A. Vermeulen, Ghent, Belgium R. Vihko, Oulu, Finland C. A. Villee, Boston, U.S.A. A. E. Wakeling, Macclesfield, England C. R. Wira, Hanover, U.S.A.

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Copyright © 1994 Elsevier Science Ltd

L I S T

Edi to r i a l Addresses

Stero id N o m e n c l a t u r e

General Review Pau l P r e n d e r g a s t , Sergio A. Ofiate,

K u r t Ch r i s t en sen and Dean P. Edwards

Minireview M a r i a I. New

Papers Anne H a n s e n Ree, Kjet i l Task6n and

Vidar Hansson

T. Ojasoo, J. P. R a y n a u d and J. C. Dot6

V

ix

O F C O N T E N T S

JANUARY

Nuclear accessory factors enhance the binding of progesterone receptor to specific target DNA

O. O r t m a n n , F. Merel l i , S. S. Stojilkovic, K.-D. Schulz, G. E m o n s and K. J. Ca t t

T. B a t t m a n n , A. Bonfils, C. B r a n c h e , J. H u m b e r t , F. Goubet , G. Teu t seh and D. Philibert

Y.-H. Zhuang , T. Ylikomi, M. Lindfors , S. P i ippo and P. T u o h i m a a

S a l m a n M. Hyder a n d George M. S tance l

R. H a m p l , O. Lap6ik, J. ~ulcov~t, L. St/trka, B. Kalvachov6, M. Dvof~ikov~i, D. N6mcov~i a n d J. Hoza

Leszek Mark iewicz a n d Er l io Gurpide

15 21-Hydroxylase deficiency congenital adrenal hyperplasia

23

31

47

55

61

S. M. Kelsey, R. D. Coldwell , H. L. J. Makin , D. S y n d e r c o m b e - C o u r t and A. C. Newland

69

Jack-Miche l Renoir , S t6phane Le Bihan , Christine Mercier-Bodard, Alex Gold, Merhdad Arjomandi, Christine Radany i and E t i e n n e - E m i l e Bau l i eu

G. Teutsch , F. Goubet , T. B a t t m a n n , A. Bonfils , F. Bouchoux, E. Cerede, D. Gottto, M. Ga i l l a rd -Kel ly and D. Philibert

A m i n a Dassouli , Mich61e Manin , Georges Veyssiere a n d Claude Jean

F. Par i s , G. F. Weinbaue r , V. Bl f im and E. Nieschlag

Jayasri Ghose-Dastidar, Reza Green a n d J. B. Alexander Ross

81

89

95

101

111

I. Jung-Tes tas , M. S c h u m a c h e r , P. Robel and E. E. Bau l i eu

Younes Maarouf i and Guy Leclercq

121

Regulation of glucocorticoid receptor (GR) mRNA and protein levels by phorbol ester in MCF-7 cells. Mechanism of GR mRNA induction and decay

A n n o u n c e m e n t s

Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data

Modulation of calcium signaling and LH secretion by progesterone in pituitary gonadotropbs and clonal pituitary cells

RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

Immunolocalization of retinoic acid receptors in rat, mouse and human ovary and uterus

In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3'-flanking region of the murine c-fos protooncogene

The effect of long-term glucocorticoid therapy on glucocorticoid receptor content and on steroid response to ACTH

Estrogenic and progestagenic activities coexisting in steroidal drugs: quantitative evaluation by in vitro bioassays with human cells

Neopterin release by myeloid leukaemic cells can be synergistically augmented by 1,25-dihydroxyvitamin D3 in combination with gamma interferon or granulocyte- macrophage colony stimulating factor

Effects of immunosuppressants FK506 and Rapamycin on the heterooligomeric form of the progesterone receptor

Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor

Androgens regulate expression of the gene coding for a mouse vas deferens protein related to the aldo-keto reductase superfamily in epithelial cell subcultures

129 The effect of androgens and antiandrogens on the immunohistochemical localization of the androgen receptor in accessory reproductive organs of male rats

139

145

155

Identification of the cysteine in the steroid-binding site of human corticosteroid binding globulin by site-directed mutagenesis and site-specific chemical modification

Actions of steroid hormones and growth factors on glial cells of the central and peripheral nervous system

Importance of A/B and C domains of the estrogen receptor for its adsorption to hydroxylapatite

III

iv

Papers Joris Winderickx, Inge Vercaeren,

Guido Verhoeven and Walter Heyns

Mar ian th i Evagelatou and John F a r r a n t

Paul Y. Sze and Zafar Iqbal

P. Van de Velde, F. Nique, F. Bouchoux, J. Br6maud, M-C. Hameau , D. Lucas, C. Morati l le , S. Viet, D. Ph i l ibe r t and G. Teutsch

Mark A. Levy, Mar t in Brandt , Kr is t ina M. Sheedy, Jeffrey T. Dinh, Dennis A. Holt, Linda M. Garr ison, Derk J. Be rgsma and Br ian W. Metca l f

R. Kra t t enm ache r , R. Knauthe, K. Parczyk, A. Walter, U. Hilgenfeldt and K. H. F r i t zemeie r

Harpa l S. Purba , Elaine J. King, Paul Richer t and Ajay S. Bha tnaga r

Gunnar S6derqvist , H~kan Olsson, Nils Wilking, Bo von Schoultz and Kjell Ca r l s t r6m

S. de Lauzon, K. M. Rajkowski and N. CittanovabxV~

Y. O'Connell , T. J. McKenna and S. K. C u n n i n g h a m

E. Di Salle, G. Briatico, D. Giudici, G. Ornat i and A. Panzer i

Shizuo Nakajin, Yoshiko Fujita, Shuji Ohno, Mihoko Uchida, Masa tada Aoki and Masato Shinoda

E d m u n d Maser and Gudula Bannenberg

M. Zenatti , N. B lanchou in-Emer ic , S. Koplewicz, G. Defaye and B. Aupe t i t -Fa i san t

Mat thew C. Wright , Alan J. Paine, Paul Skett and Rober t Auld

M. Gani, J. Coley, J. Piron, A. S. Humphreys , J. Arevalo, I. A. Wilson and M. J. Taussig

Sara Antonia Li, Yah Xue, Qiu Xie, Chr i s topher I. Li and Jonathan J. Li

M. Feuilloley, O. Lesouhait ier , C. Delarue, S. De Marchis , J. M. Conlon, H. A. Bern and H. Vaudry

Shehnaz B. Patel , I k ram Khatkhatay, Meena P. Desai, Shr ikant S. Be t rabe t and Villi S. Toddywalla

Annet te LaMorte , Narender Kumar , C. Wayne Bard in and Kalyan S u n d a r a m

C o r r i g e n d u m

List of Conten ts

F E B R U A R Y

165

171

179

187

Androgen-dependent expression of cystatin-related protein (CRP) in the exorbital lacrimal gland of the rat

Effect of 17fl-estradiol on immunoglobulin secretion by human tonsillar lympho- cytes in vitro

Glucocorticoid actions on synaptic plasma membranes: modulation of [x25I] calmodulin binding

RU 58 668, a new pure antiestrogen inducing a regression of human mammary carcinoma implanted in nude mice

197 Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5~-reductase isoform 2

207 Estrogen action on hepatic synthesis of angiotensinogen and IGF-I: direct and indirect estrogen effects

215 Effect of aromatase inhibitors on estrogen 2-hydroxylase in rat liver

221 Metabolism of estrone sulfate by normal breast tissue: influence of menopausal status and oral contraceptives

225 Investigation of a 17fl-estradiol-monoclonal antiestradiol antibody binding mech- anism using dilute solutions of organic solvents

235 The effect of prolactin, human chorionic gonadotropin, insulin and insulin-like growth factor 1 on adrenal steroidogenesis in isolated guinea-pig adrenal cells

241 Endocrine properties of the testosterone 5~-reductase inhibitor turosteride (FCE 26073)

249 Purification and characterization of 3ct/fl-hydroxysteroid dehydrogenase from mature porcine testicular cytosol

257 The purification of 1 l fl-hydroxysteroid dehydrogenase from mouse liver micro- somes

265 Suramin: an inhibitor of the final steps of the mineralocorticoid pathway?

271

277

283

287

293

297

Induction of rat hepatic glucocorticoid-inducible cytochrome P450 3A by metyrapone

Monoclonal antibodies against progesterone: effect of steroid-carrier coupling position on antibody specificity

Serum and tissue levels of estradiol during estrogen-induced renal tumorigenesis in the Syrian hamster

In vitro study of the effect of urotensin II on corticosteroid secretion in the frog Rana ridibunda

A sensitive ELISA for 6fl-hydroxycortisol in urine using enzyme penicillinase (fl-lactamase)

Aromatization of 7~-methyl-19-nortestosterone by human placental microsomes in vitro

305

Papers Sylvette Ayala-Torres , Bet ty H. Johnson and

E. Brad Thompson

P. De Vos, F. Claessens, L. Celis, B. Peeters, W. Rombauts , W. Heyns and G. Verhoeven

M. Borr~is, L. Hardy, F. Lempereur, A. H. El Khissiin, N. Legros, R. Gol-Winkler and G. Leclercq

Karen E. Sheppard

Sylvie D61os, Ca ther ine Iehl6, Pierre-Marie Mar t in and Jean-Pierre Raynaud

P ie ra Rebuffat , Anna S. Belloni, Francesco G. Musajo, Stefano Rocco, Anna Markowska, Guiseppina Mazzocchi and Gastone G. Nussdorfer

F. Cadepond, N. J ibard, N. Binar t , G. Schweizer -Groyer , I. Sega rd -Maure l and E. E. Baul ieu

Charles N. Falany, James Wheeler , Tae Sung Oh and Josie L. Falany

Eisuke P. Murono, Amie L. Washburn and Deborah P. Gofor th

Rub6n W. Car6n, Ana M. Salicioni and Ricardo P. Deis

Siegfried Schwarz and Peter Pohl

U. Kuhnle, U. Lindl, U. Keller, D. Arman in i , M. Meure r and S. Baur

D. B. Gower, K. T. Holland, A. I. Mallet, P. J. Rennie and W. J. Watkins

List of Conten ts

M A R C H

307

317

325

Oxysterol sensitive and resistant lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA

Nuclear extracts enhance the interaction of fusion proteins containing the DNA- binding domain of the androgen and glucocorticoid receptor with androgen and glucocorticoid response elements

Estradiol-induced down-regulation of estrogen receptor. Effect of various modulators of protein synthesis and expression

337

347

353

Calcium and protein kinase C regulation of the glucocorticoid receptor in mouse corticotrope tumor cells

Inhibition of the activity of 'basic' 5~-reductase (type 1) detected in DU 145 ceils and expressed in insect cells

Evidence that endogenous somatostatin (SRIF) exerts an inhibitory control on the function and growth of rat adrenal zona glomerulosa. The possible involvement of zona medullaris as a source of endogenous SRIF

361 Selective deletions in the 90 kDa heat shock protein (hsp90) impede hetero- oligomeric complex formation with the glucocorticosteroid receptor (GR) or hormone binding by GR

369 Steroid sulfation by expressed human cytosolic sulfotransferases

377

385

391

403

409

Enhanced stimulation of 5~-reductase activity in cultured Leydig cell precursors by human chorionic gonadotropin

Mifepristone treatment demonstrates the participation of adrenal glucocorticoids in the regulation of oestrogen-induced prolactin secretion in ovariectomized rats

Steroids and opioid receptors

Androgen binding sites in peripheral human mononuclear leukocytes of healthy males and females

Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora--a mechanism for axillary odour production in man?

General Review Liam J. M u r p h y

Papers Donald P. McDonnel l , Mauoucheh r M. Shabaz,

El i sabet ta Vegeto and Mark E. Goldman

Alice H. Cavanaugh and S. Stoney S imons Jr

Mar ie Salomonsson, Johan H/iggblad, Ber t W. O'Malley and Gisela M. Si tbon

Norbe r t Schfitze, Giinter Vol lmer and Rudol f Knuppen

Huber t H. Thole

E. L. El fahime, J. M. F61ix and B. Koch

A P R I L

419 Growth factors and steroid hormone action in endometrial cancer

425

433

447

453

463

467

The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity

Factor-assisted DNA binding as a possible general mechanism for steroid recep- tors. Functional heterogeneity among activated receptor-steroid complexes

The human estrogen receptor hormone binding domain dimerizes independently of ligand activation

Catecholestrogens are agonists of estrogen receptor dependent gene expression in MCF-7 cells

The side chains responsible for the dimerization of the estradiol receptor by ionic bonds are lost in a 17 kDa fragment extending downstream from aa 303

Antagonistic effects of retinoic acid and triiodothyronine in the expression of corticoid-binding globulin (CBG) by cultured fetal hepatocytes

Anu Pekki, Timo Ylikomi, Heimo Syval/i and 475 Progesterone receptor and hsp90 are not complexed in intact nuclei Pen t t i Tuoh imaa

vi List of Conten ts

Chris topher J. Newton, Rosa Buric, Thors ten Trapp, Steffi Brockmeier , Uber to Pagot to and Giinter K. Stalla

Giinter Vollmer, Hors t Michna, Mar t in R. Schne ider and Rudol f Knuppen

Lawrence B. Hendry, Chung K. Chu, John A. Copland and Vi rendra B. Mahesh

Giuseppina Mazzocchi, Ludwik K. Malendowicz and Gastone G. Nussdorfer

Alfred v. Krempe lhube r , Frank Miiller and Ulrike F u h r m a n n

Gian Paolo Rossini and Claudia Malaguti

A. Purohi t , N. M. Howarth , B. V. L. Po t t e r and M. J. Reed

Naoko Mouri Yamada, Shuji Hira ta and Junzo Kato

Annu Makker, M. M. Singh, S. R. Chowdhury , S. C. Mai t ra and V. P. Kamboj

M. W. Khalil, B. Strut t , D. Vachon and D. W. Kil l inger

C. Longcope, C. Flood and J. Tast

Kaoru Nasuda, Akira Endoh and Yoshio Igarashi

T. R. Jeffry Evans, Mar t in G. Rowlands, Sur inder S. Sahota and R. Char les Coombes

Norihi ro Kobayashi, Akihiko Hisada and Kazutake Sh im ada

Wilhelm Kuhnz, B a r b a r a Schii t t and Rolf Woloszczak

481 The unliganded estrogen receptor (ER) transduces growth factor signals

487

495

507

Stromal expression of tenascin is inversely correlated to epithelial differentiation of hormone dependent tissues

Antiestrogenic piperidinediones designed prospectively using computer graphics and energy calculations of DNA-ligand complexes

Stimulatory effect of vasoactive intestinal peptide (VIP) on the secretory activity of dispersed rat adrenocortical cells. Evidence for the interaction of VIP with ACTH receptors

511 DNA-binding of androgen receptor overexpressed in mammalian cells

517 The subcellular distribution of glucocorticoid-receptor complexes as studied by chemical crosslinking of intact HTC cells

523 Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer

529 Distribution and postnatal changes of aromatase mRNA in the female rat brain

535 Uterine estradiol and progesterone receptor concentration in relation to circulating hormone levels and histoarchitecture during high endometrial sensitivity and induced decidualization in guinea pigs

545 Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7ct-hydroxydehydroepiandrosterone by human adipose stromal cells

553 The effects of ovariectomy and progesterone on peripheral aromatization in the female rhesus monkey

557 Biphasic regulation by N6,2"-O-dibutyryl adenosine 3',5'-cyclic monophosphate (dbcAMP) of steroid 21-hydroxylase activity in rat hepatocytes

563 Lack of inhibition of placental estrone sulfatase and aromatase enzymes by vitamin D~ and its analogs

567 Specificity of the polyclonal antibodies raised against a novel 25-hydroxyvitamin D3-bovine serum albumin conjugate linked through the C-1 la position

573 Influence of changes in the concentration of sex hormone-binding globulin in human serum on the protein binding of the contraceptive steroids levonorgestrel, 3-keto-desogestrel and gestodene

Book Reviews 581

S U B J E C T I N D E X

A C T H effect of long term glucocorticoid therapy on glucocorticoid receptor content and on steroid response to, 81 receptor

evidence for the interaction of vasoactive intestinal peptide with, 507 Adipose stromal cells

effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7~-hydroxydehydroepiandrosterone by, 545 Adrenal cells

effect of prolactin, human chorionic gonadotropin, insulin and insulin-like growth factor 1 on adrenal steroidogenesis in isolated, of guinea-pig, 235

Adrenal zona glomerulosa evidence that endogenous somatostatin exerts an inhibitory control on the function and growth of, in rat, 353

Alopecia RU 58841, a new antiandrogen candidate for the treatment of androgenetic, 55

Androgen(s) binding sites in peripheral human mononuclear leukocytes of healthy males and females, 403 -dependent expression of cystatin-related protein in the exorbital lacrimal gland of the rat, 165 effect of, and antiandrogens on the immunohistochemical localization of the androgen receptor in accessory reproductive organs

of male rats, 129 receptor

DNA-bind ing of, overexpressed in mammalian cells, 511 nonsteroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the, 111

regulate expression of the gene coding for a mouse vas deferens protein, 121 Androgen response elements

nuclear extracts enhance the interaction of fusion proteins containing the DNA-binding domain of the androgen receptor with, 317

16-Androstene steroid concentrations of, in sterile apocrine sweat and axillary secretions, 409

Angiotensinogen estrogen action on hepatic synthesis of, 207

Antiandrogen(s) effect of, on the immunohistochemcal localization of the androgen receptor in accessory reproductive organs of male rats,

129 nonsteroidal, synthesis and biological profile of high-affinity ligands for the androgen receptor, 111 RU 58841, a new candidate for the treatment of acne, androgenetic alopecia and hirsutism, 55

Antiestrogen(s) RU 58668, a new pure, inducing a regression of human mammary carcinoma implanted in nude mice, 187

Antiestrogenic piperidinediones designed prospectively using computer graphics and energy calculations of DNA-l igand complexes, 495

Aromatase distribution and postnatal changes of, mRNA in the female rat brain, 529 inhibitor(s)

effect of, on estrogen 2-hydroxylase in rat liver, 215 lack of inhibition of placental estrone sulfatase and, enzymes by vitamin D 3 and its analogues, 563

Aromatization effects of ovariectomy and progesterone on peripheral, in the female rhesus monkey, 553

Axillary odour a mechanism for, production in man, 409

Brain distribution and postnatal changes of aromatase mRNA in the, of female rat, 529

Breast metabolism of estrone sulfate by normal, tissue, 221

Breast cancer inhibition of steroid sulphatase activity by steroidal methylthiophosphonates, potential therapeutic agents in, 523

Calmodulin modulation of [125I]-, binding, 179

Catecholestrogen(s) agonists of estrogen receptor dependent gene expression in M C F - 7 cells, 453

Congenital adrenal hyperplasia 21-hydroxylase deficiency in, 15

Corticosteroid binding globulin identification of the cysteine in the steroid-binding site of human, 139

vii

viii Subject Index

Corticotrope tumor cells calcium and protein kinase C regulation of the glucocorticoid receptor in, of mouse, 337

Cystatin-related protein androgen-dependent expression of, in the exorbital lacrimal gland of the rat, 165

Cytochrome P450 effect of dexamethasone and, inhibitors on the formation of 7~t-hydroxydehydroepiandrosterone by human adipose stromal cells,

545 induction of rat hepatic glucocorticoid-inducible, 3A by metyrapone, 271

Dexamethasone effect of, and cytochrome P450 inhibitors on the formation of 7~t-hydroxydehydroepiandrosterone by human adipose stromal

cells, 545 1,25-Dihydroxyvitamin D 3

neopterin release by myeloid leukaemic cells can be synergistically augmented by, 95 D N A

-binding of androgen receptor overexpressed in mammalian cells, 511 factor-assisted, binding as a possible general mechanism for steroid receptors, 433 nuclear accessory factors enhance the binding of progesterone receptor to specific target, 1

DNA-binding domain nuclear extracts enhance the interaction of fusion proteins containing the, of the androgen and glucocorticoid receptors with

androgen and glucocorticoid response elements, 317 DU 145 cells

inhibition of the activity of 'basic' 5~-reductase (Type 1) detected in, and expressed in insect cells, 347

Endometrial cancer growth factors and steroid hormone action in, 419

Epristeride a selective and specific uncompetitive inhibitor of human steroid 5~t-reductase isoform 2, 197

Estradiol effect of 17fl-, on immunoglobulin secretion by human tonsillar lymphocytes in vitro, 171 -induced down-regulation of estrogen receptor, 325 monoclonal anti-, antibody binding mechanism using dilute solutions of organic solvents, 225 receptor

the side chains responsible for the dimerization of the, 463 serum and tissue levels of, during estrogen-induced renal tumorigenesis in the Syrian hamster, 283

Estrogen(s) action on hepatic synthesis of angiotensinogen and I G F - I , 207 receptor

human, hormone binding domain dimerizes independently of ligand activation, 447 importance of A/B and C domains of the, for its adsorption to hydroxylapatite, 155 in vitro interaction of uterine, with the estrogen response element present in the 3'-flanking region of the murine c-los

protooncogene, 69 the unliganded, transduces growth factor signals, 481

Estrogen response element in vitro interaction of uterine estrogen receptor with the, present in the 3'-flanking region of the murine c-fos protooncogene,

69 Estrone sulfatase

lack of inhibition of placental, and aromatase enzymes by vitamin D 3 and its analogues, 563 Estrone sulfate

metabolism of, by normal breast tissue, 221

c-los protooncogenes in vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3'-flanking region of the murine,

69

Gene androgens regulate expression of the, coding for a mouse vas deferens protein, 121

Glial cells actions of steroid hormones and growth factors on, of the central and peripheral nervous system, 145

Glucocorticoid(s) receptor(s)

actions on synaptic plasma membranes, 179 calcium and protein kinase C regulation of the, in mouse corticotrope tumor cells, 337 effect of long term gtucocorticoid therapy on, content, 81 effects of, on cytochrome P450 in rat liver, 271 heat shock protein 90 impedes hetero-oligomeric complex formation with the, or hormone binding by, 361 subcellular distribution of, complexes by chemical crosslinking of intact H T C cells, 517

Glucocorticoid response elements nuclear extracts enhance the interaction of fusion proteins containing the DNA-binding domain of the androgen and of the

glucocorticoid receptor with, 317

Subject Index ix

Granulocyte-macrophage colony stimulating factor neopterin release by myeloid leukaemic cells can be synergistically augmented by 1,25-dihydroxyvitamin D 3 in combination with,

95 Growth factor(s)

actions of, on glial cells of the central and peripheral nervous system, 145 and steroid hormone action in endometrial cancer, 419 effect of insulin-like, -1 on adrenal steroidogenesis in isolated guinea-pig adrenal cells, 235 the unliganded estrogen receptor transduces, signals, 481

Hepatocytes biphasic regulation of steroid 21-hydroxylase activity in, of rat, 557

Heat shock protein progesterone and, -90 are not complexed in intact nuclei, 475 selective deletions in the -90 kDa, impede hetero-oligomeric complex formation with the glucocorticosteroid receptor (GR) or

hormone binding by GR, 361 Hirsutism

RU 58841: a new specific topical antiandrogen as a candidate for the treatment of, 55 Hormone dependent tissues

stromal expression of tenascin is inversely correlated to epithelial differentiation of, 487 Human chorionic gonadotropin

effect of, on adrenal steroidogenesis in isolated guinea-pig adrenal cells, 235 enhanced stimulation of 5~-reductase activity in cultured Leydig cell precursors by, 377

Human mammary carcinoma RU 58668: a new pure antiestrogen inducing a regression of, implanted in nude mice, 187

6/3-Hydroxycortisol a sensitive E L I S A for, in urine using enzyme penicillinase, 293

21-Hydroxylase biphasic regulation of steroid, activity in rat hepatocytes, 557 deficiency in congenital adrenal hyperplasia, 15

3~//3-Hydroxysteroid dehydrogenase purification and characterization of, from mature porcine testicular cytosol, 249

1 l f l -Hydroxysteroid dehydrogenase purification of, from mouse liver microsomes, 257

25-Hydroxyvitamin D 3 specificity of the polyclonal antibodies raised against a novel, bovine serum albumin conjugate, 567

Insulin effect of, on adrenal steroidogenesis in isolated guinea-pig adrenal cells, 235

Insulin growth factor I ( I G F - I ) estrogen action on hepatic synthesis of, 207 effect of, on adrenal steroidogenesis in isolated guinea-pig adrenal cells, 235

7-Interferon neopterin release by myeloid leukaemic cells can be synergistically augmented by 1,25-dihydroxyvitamin D3 in combination with,

95

Leydig cell(s) enhanced stimulation of 5~-reductase activity in cultured, precursors by human chorionic gonadotropin, 377

Luteinizing hormone modulation of calcium signaling and, secretion by progesterone in pituitary gonadotrophs and clonal pituitary cells, 47

Lymphocytes effect of 17/~-estradiol on immunoglobulin secretion by human tonsillar, in vitro, 171

Lymphoid cells oxysterol sensitive and resistant, 307

MCF-7 breast cancer cells catechol estrogens are agonists of estrogen receptor dependent gene expression in, 453 regulation of glucocorticoid receptor mRNA and protein levels by phorbol ester in, 23

Messenger RNA correlation of oxysterol sensitive and resistant lymphoid cells with, regulation of cellular nucleic acid binding protein, 307 distribution and postnatal changes of aromatase, in the female rat brain, 529

Metyrapone induction of rat hepatic glucocorticoid-inducible cytochrome P450 3A by, 271

Mifepristone effect of, in the regulation of oestrogen-induced prolactin secretion in ovariectomized rats, 385

Mineralocorticoids (s) suramin: an inhibitor of the final steps of the, pathway, 265

Monoclonal antibodies binding mechanism of 17/3-estradiol-, against estradiol using dilute solutions of organic solvents, 225 effect of steroid-carrier coupling position on antibody specificity of, against progesterone, 277

x Subject Index

Mononuclear leukocytes androgen binding sites in peripheral human, of healthy males and females, 403

Opioid(s) steroids and receptors of, 391

Oxysterol effects on lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA, 307

Placenta aromatization of 7~-methyl-19-nortestosterone by human, microsomes in vitro, 297 lack of inhibition of, estrone sulfatase and aromatase enzymes by vitamin D3 and its analogues, 563

Progesterone effects of, on peripheral aromatization in the female rhesus monkey, 553 modulation of calcium signaling and L H secretion by, in pituitary gonadotrophs and clonal pituitary cells, 47 monoclonal antibodies against, 277 receptor(s)

hsp90 and, are not complexed in intact nuclei, 475 human, A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity, 425 nuclear accessory factors enhance the binding of, to specific target DNA, 1

Prolactin effect of, on adrenal steroidogenesis in isolated guinea-pig adrenal cells, 235

Protein kinase C regulation of the glucocorticoid receptor in mouse corticotrope tumor cells by, 337

Rapamycin effects of, on the heterooligomeric form of the progesterone receptor, 101

Receptor(s) A C T H

interaction of vasoactive intestinal peptide with, 507 androgen(s)

DNA-binding of, overexpressed in mammalian cells, 511 non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the, 111

estrogen(s) catecholestrogens are agonists of, dependent gene expression in MCF-7 cells, 453 estradiol-induced down-regulation of, 325 human, hormone binding domain dimerizes independently of ligand activation, 447 importance of A/B and C domains of, for adsorption to hydroxylapatite, 155 interaction of uterine, with the estrogen response element present in the 3'-flanking region of the routine c-los protooncogene,

69 side chains responsible for the dimerization of, by ionic bonds, 463 unliganded, transduces growth factor signals, 481 uterine concentration of, in guinea pigs, 535

glucocorticoid (s) calcium and protein kinase C regulation of, in mouse corticotrope tumor cells, 337 effect of long term glucocorticoid therapy on, content, 81 regulation of, mRNA by phorbol ester in MCF-7 cells, 23 selective deletions in the 90 kDa heat shock protein impede hetero-oligomeric complex formation with, or hormone binding

by, 361 subcellular distribution of, complexes as studied by chemical crosslinking of intact H T C cells, 517

mineralocorticoid the human progesterone receptor A-form functions as a transcriptional modulator of, transcriptional activity, 425

opioid steroids and, 391

progesterone effects of immunosuppressants FK506 and Rapamycin on the heterooligomeric form of the, 101 hsp90 and, are not complexed in intact nuclei, 475 human, A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity, 425 nuclear accessory factors enhance the binding of, to specific target DNA, 1 uterine concentration of, in guinea pigs, 535

retinoic acid immunolocalization of, in rat, mouse and human ovary uterus, 61

steroid(s) affiliations among, as revealed by multivariate analysis of steroid binding data, 47 factor-assisted DNA binding as a possible general mechanism for, 433

5a-Reductase endocrine properties of the testosterone, inhibitor turosteride, 241 enhanced stimulation of, activity in cultured Leydig cell precursors by human chorionic gonadotropin, 377 epristeride is a selective and specific uncompetitive inhibitor of human steroid, isoform 2, 197 inhibition of the activity of 'basic', (Type 1) detected in DU 145 cells and expressed in insect cells, 347

Subject Index xi

Renal tumorigenesis serum and tissue levels of estradioi during estrogen-induced, in the Syrian hamster, 283

Retinoic acid antagonistic effects of, in the expression of corticoid-binding globulin by cultured fetal hepatocytes, 467 receptor

immunolocalization of, in rat, mouse and human ovary and uterus, 61

Sex hormone-binding globulin influence of changes in the concentration of, in human serum on the protein binding of the contraceptive steroids levonorgestrel,

3-keto-desogestrel and gestodene, 573 Somatostatin

evidence that endogenous, exerts an inhibitory control on the function and growth of rat adrenal zona glomerulosa, 353 Steroidal drugs

estrogenic and progestagenic activities coexisting in, quantitative evaluation by in vitro bioassays with human cells, 89 Steroid(s)

actions of, hormones on glial cells of the central and peripheral nervous system, 145 and opioid receptors, 391 growth factors and, hormone action in endometrial cancer, 419 sulfation by expressed human cytosolic sulfotransferases, 369

Steroid sulphatase(s) inhibition of, activity by steroidal methylthiophosphonates, 523

Sulfotransferase (s) steroid sulfation by expressed human cytosolic, 369

Suramin an inhibitor of the final steps of the mineralocorticoid pathway, 265

Tenascin stromal expression of, is inversely correlated to epithelial differentiation of hormone dependent tissues, 487

Triiodothyronine antagonistic effects of, in the expression of corticoid-binding globulin by cultured fetal hepatocytes, 467

Turosteride endocrine properties of the testosterone 5~t-reductase inhibitor, 241

Urotensin II effects of, on corticosteroid secretion in the frog Rana ridibunda, 287

Uterus estradiol and progesterone receptor concentration in, in relation to circulating hormone levels in guinea pigs, 535

Vasoactive intestinal peptide stimulatory effect of, on the secretory activity of dispersed rat adrenocortical cells, 507

We would like to express our deep thanks to the following people for their kind collaboration in reviewing papers for The Journal of Steroid Biochemistry and Molecular Biology:

Drs L. Amundadot t i r , Washington, U.S.A.; A. Belanger, Ste Foy, Canada; A. Colletta, London, England; C. Denef, Leuven, Belgium; W. L. Duax, Buffalo, U.S.A.; C. R. W. Edwards, Edinburgh, Scotland; D. E1 Ashry, Washington, U.S.A.; M. Govindan, Ste Foy, Canada; D. Hansell, Washington, U.S.A.; W. Heyns, Leuven, Belgium; J. W. Honour, London, England; P. J. Hornsby, Houston, U.S.A.; M. D. Johnson, Washington, U.S.A.; J. A. Katzenellenbogen, Urbana, U.S.A.; C. Knabbe, Hamburg, Germany; K. Lee, London, England; C. Monder, New York, U.S.A.; C. Newton, Munich, Germany; R. A. Oakley, Chapel Hill, U.S.A.; M. G. Rowlands, Sutton, England; R. J. Sherins, Fairfax, U.S.A.; P. M. Stewart, Birmingham, England; D. B. Tully, Chapel Hill, U.S.A.; F. Vignon, Montpellier, France; W. Wahli, Lausanne, Switzerland; C. K. W. Watts, Darlinghurst, Australia.

A U T H O R I N D E X

Aoki M., 249 Arevalo J., 277 Arjomandi M., 101 Armanini D., 403 Auld R., 27l Aupetit-Faisant B., 265 Ayala-Torres S., 307

Bannenberg G., 257 Bardin C. W., 297 Battmann T., 55, 111 Baulieu E.-E., 101, 145, 361 Baur S., 403 Belloni A. S., 353 Bergsma D. J., 197 Bern H. A., 287 Betrabet S. S., 293 Bhatnagar A. S., 215 Binart N., 361 Blanchouin-Emeric N., 265 Blfim V., 129 Bonfils A., 55, 111 Borr~is M., 325 Bouchoux F., 111, 187 Branche C., 55 Brandt M., 197 Br6maud J., 187 Briatico G., 241 Brockmeier S., 481 Buric R., 481

Cadepond F., 361 Carlstr6m K., 221 Car6n R. W., 385 Catt K. J., 47 Cavanaugh A. H., 433 Celis L., 317 Cerede E., 111 Chowdhury S. R., 535 Christensen K., 1 Chu C. K., 495 Cittanova N., 225 Claessens F., 317 Coldwell R. D., 95 Coley J., 277 Conlon J. M., 287 Coombes R. C., 563 Copland J. A., 495 Cunningham S. K., 235

Dassouli A., 121 De Marchis S., 287 De Vos P., 317 Defaye G., 265 Deis R. P., 385 Delarue C., 287 D~Ios S., 347 Desai M. P., 293 Di Salle E., 241 Dinh J. T., 197 Dor6 J. C., 31 Dvo~ikov~ M., 81

Edwards D. P., 1 Elfahime E. L., 467 El Khissiin A. H., 325 Emons G., 47

Endoh A., 557 Evagelatou M., 171 Evans T. R. J., 563

Falarty C. N., 369 Falany J. L., 369 Farrant J., 171 F6lix J. M., 467 Feuilloley M., 287 Flood C., 553 Fritzemeier K. H., 207 Fuhrmann U., 511 Fujita Y., 249

Gaillard-Kelly M., 111 Gani M., 277 Garrison L. M., 197 Ghose-Dastidar J., 139 Giudici D., 241 Gofflo D., 111 Goforth D. P., 377 Gol-Winkler R., 325 Gold A., 101 Goldman M. E., 425 Goubet F., 55, 111 Gower D. B., 409 Green R., 139 Gurpide E., 89

H~iggblad J., 447 Hameau M.-C., 187 Hampl R., 81 Hansen Ree A., 23 Hansson V., 23 Hardy L., 325 Hendry L. B., 495 Heyns W., 165, 317 Hilgenfeldt U., 207 Hirata S., 529 Hisada A., 567 Holland K. T., 409 Holt D. A., 197 Howarth N. M., 523 Hoza J., 81 Humbert J., 55 Humphreys A. S., 277 Hyder S. M., 69

Iehl6 C., 347 Igarashi Y., 557 Iqbal P. Y., 179

Jean C., 121 Jibard N., 361 Johnson B. H., 307 Jung-Testas I., 145

Kalvachov~ B., 81 Kamboj V. P., 535 Kato J., 529 Keller U., 403 Kelsey S. M., 95 Khalil M. W., 545 Khatkhatay I., 293 Killinger D. W., 545 King E. J., 215 Knauthe R., 207

xiii

Knuppen R., 453, 487 Kobayashi N., 567 Koch B., 467 Koplewicz S., 265 Krattenmacher R., 207 v. Krempelhuber A., 511 Kuhnle U., 403 Kuhnz W., 573 Kumar N., 297

LaMorte A., 297 Lap6ik O., 81 de Lauzon S., 225 Le Bihan S., 101 Leclercq G., 155, 325 Legros N., 325 Lempereur F., 325 Lesouhaitier O., 287 Levy M. A., 197 Li C. I., 283 Li J. J., 283 Li S. A., 283 Lindfors M., 61 Lindl U., 403 Longcope C., 553 Lucas D., 187

Maaroufi Y., 155 Mahesh V. B., 495 Maitra S. C., 535 Makin H. L. J., 95 Makker A., 535 Malaguti C., 517 Malendowicz L. K., 507 Mallet A. I., 409 Manin M., 121 Markiewicz L., 89 Markowska A., 353 Martin P.-M., 347 Maser E., 257 Mazzocchi G., 353, 507 McDonnell D. P., 425 McKenna T. J., 235 Mercier-Bodard C., 101 Merelli F., 47 Metcalf B. W., 197 Meurer M., 403 Michna H., 487 Moratille C., 187 Miiller F., 511 Murono E. P., 377 Murphy L. J., 419 Musajo F. G., 353

Nakajin S., 249 Nasuda K., 557 N6mcovfi D., 81 New M. I., 15 Newland A. C., 95 Newton C. J., 481 Nieschlag E., 129 Nique F., 187 Nussdorfer G. G., 353, 507

O'Connell Y., 235 O'Malley B. W., 447 Oh T. S., 369

xiv Author Index

Ohno S., 249 Ojasoo T., 31 Olsson H., 221 Ofiate S. A., 1 Ornati G., 241 Ortmann O., 47

Pagotto U., 481 Paine A. J., 271 Panzeri A., 241 Parczyk K., 207 Paris F., 129 Patel S. B., 293 Peeters B., 317 Pekki A., 475 Philibert D., 55, 111, 187 Piippo S., 61 Piron J., 277 Pohl P., 391 Potter B. V. L., 523 Prendergast P., 1 Purba H. S., 215 Purohit A., 523

Radanyi C., 101 Rajkowski K. M., 225 Raynaud J. P., 31,347 Rebuffat P., 353 Reed M. J., 523 Rennie P. J., 409 Renoir J.-M., 101 Richert P., 215 Robel P., 145 Rocco S., 353 Rombauts W., 317 Ross J. B. A., 139 Rossini G. P., 517 Rowlands M. G., 563

Sahota S. S., 563 Salicioni A. M., 385 Salomonsson M., 447 Schneider M. R., 487 yon Schoultz B., 221 Schulz K.-D., 47 Schumacher M., 145 Schfitt B., 573 Schfitze N., 453 Schwarz S., 391 Schweizer-Groyer G., 361 Segard-Maurel I., 361 Shabaz M. M., 425 Sheedy K. M., 197 Sheppard K. E., 337 Shimada K., 567 Shinoda M., 249 Singh M. M., 535 Sitbon G. M., 447 Skett P., 271 S6derqvist G., 221 Stalla G. K., 481 Stancel G. M., 69 St~rka L., 81 Stojilkovic S. S., 47 Stoney Simons S. Jr, 433 Strutt B., 545 ~ulcovfi J., 81 Sundaram K., 297 Syndercombe-Court D., 95 Syv~lfi H., 475 Sze P. Y., 179

Thompson E. B., 307 Toddywalla V. S., 293 Trapp T., 481 Tuohimaa P., 61, 475

Uchida M., 249

Vachon D., 545 Van de Velde P., 187 Vaudry H., 287 Vegeto E., 425 Vercaeren I., 165 Verhoeven G., 165, 317 Veyssiere G., 121 Viet S., 187 Vollmer G., 453, 487

Walter A., 207 Washburn A. L., 377 Watkins W. J., 409 Weinbauer G. F., 129 Wheeler J., 369 Wilking N., 221 Wilson I. A., 277 Winderickx J., 165 Woloszczak R., 573 Wright M. C., 271

Xie Q., 283 Xue Y., 283

Task6n K., 23 Yamada N. M., 529 Tast J., 553 Ylikomi T., 61,475 Taussig M. J., 277 Teutsch G., 55, 111, 187 Zenatti M., 265 Thole H. H., 463 Zhuang Y.-H., 61

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