Volume InformationSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 62, No. 1 (Jan. 15, 1969), pp. i-viiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/58802 .

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Proceedings of the

National Academy of Sciences

of the United States of America

VOLUME 62 JANUARY-APRIL 1969

EDITRA B OF TPR EI

A4-

EDTRILBOR F H POEEIG

JOHN T. EDSALL, Chairman

WALTER KAUZMANN, Vice Chairman JAMES V. NEEL, Vice Chairman

MERLE A. TUVE, Home Secretary HARRISON S. BROWN, Foreign Secretary

E. R. PIORE, Treasurer

C. B. ANFlNSISEN

H. W. BODE

BERNARD D. DAVIS

CARL DJERASSI

KATHERINE ESAU

WILLIAM A. FOWLER

HERBERT FRIEDMAN

GORDON J. F. MACDONALD

THEODORE T. PUCK

H. L. SHAPIRO

EMIL L. SMITH

JOSEPH L. WALSH

JOSEPHINE A. WILLIAMS, Editorial Associate

PUBLISHED MONTHLY BY THE NATIONAL ACADEMY OF SCIENCES

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CONTENTS

INFORMATION TO CONTIIBUTOIIS TO TIHE PtOCEEDINGS O1 '1HE NATIONAL ACADEMY

OF SCIENCES. 1

PIHYSICAL SCIENCES

MATHEMATICS

ON THE THOMAS-FERMI EQUATION. By Einar Hille 7 PROBABILITY DISTRIBUTIONS RELATED T'O THE LAW OF THE ITERATED LOGARITHM

.By H. Robbins and D. Siegmund 11 RANDOM EVOLUTIONS, MARKOV CHAINS, AND SYSTEMS OF PARTIAL DIFFERENTIAL

EQUATIONS .By R. J. Griego and R. Hersh 305 FUNDAMENTAL DOMAINS FOR LATTICES IN RANK ONE SEMISIMPLE LIE GROUPS .

.By H. Garland and M. S. Raghunathan 309 RIEMANNIAN MANIFOLDS ADMITTING A CONFORMAL TRANSFORMATION GROUP

By Kentaro Yano 314 THETA CONSTANTS, MODULI, AND COMPACT RIEMANN SURFACES . By H. M. Farkas 320 ON CLOSED EXTENSIONS OF FUNCTIONS .By R. F. Dickman, Jr. 326 THE DIFFERENTIABILITY OF THE RIEMANN FUNCTION AT CERTAIN RATIONAL MULTIPLES

OF r .By Joseph Gerver 668 THE RADICAL OF A JORDAN ALGEBRA .By Kevin McCrimmon 671 Two KINDS OF THETA CONSTANTS AND PERIOD RELATIONS ON A RIEMANN SURFACE .

.By H. M. Farkas and Harry E. Rauch 679 FAKE TORI, T.HE ANNULUS CONJECTURE, AND THE CONJECTURES OF KIRBY .

.By W. C. Hsiang and J. L. Shaneson 684 TRANSLATION OPERATORS ON THE HALF-LINE . . By L. A. Coburn and R. G. Douglas 1010 SCHWARZ'S LEMMA IN NORMED LINEAR SPACES .By Lawrence A. Harris 1017

PHYSICS

ELECTRON SPIN RESONANCE OF AN IRRADIATED SINGLE CRYSTAL OF L-TYROSINE-HCL

.By Edwin L. Fasanella and Walter Gordy 299

ENGINEERING

FATIGUE CRACK NUCLEATION IN METALS. . . . . By T. H. Lin and Y. M. Ito 631

CHEMISTRY

THE INFLUENCE OF SHORT-RANGE INTERACTIONS ON PROTEIN CONFORMATION, II. A MODEL FOR PREDICTING THE a-HELICAL REGIONS OF PROTEINS.

.By D. Kotelchuck and H. A. Scheraga 14 CIRCULAR DICHROISM OF NUCLEOSIDE DERIVATIVES, VI. THE OPTICALLY ACTIVE

BANDS OF ADENINE NUCLEOSIDE DERIVATIVES

. By Daniel W. Miles, Morris J. Robins, Roland K. Robins, and Henry Eyring 22 THE EFFECT OF PRESSURE ON THE OXIDATION STATE OF IRON, IV. THIOCYANATE AND

ISOTHIOCYANATE LIGANDS .By S. C. Fung and H. G. Drickamer 38 THE USE OF NUCLEAR MAGNETIC RESONANCE TO DESCRIBE RELATIVE MODES OF

BINDING TO LYSOZYME OF HOMOLOGOUS INHIBITORS AND RELATED SUBSTRATES .

. By M. A. Raftery, F. W. Dahlquist, S. M. Parsons, and R. G. Wolcott 44 CYCLIC OXONIUM IONS AND RELATED STRUCTURES.

.By Robert J. Gargiulo and D. Stanley Tarbell 52 TOTAL SYNTHESIS OF dl-19-NOR-16,17-DEHYDROPROGESTERONE

By Sol J. Daum, Robert L. Clarke, Sydney Archer, and William S. Johnson 333

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ii CONTENTS

SOME REMARKS ABOUT LIQUID METALS .By Dan McLachlan, Jr. 337 RESONANCE STABILIZATION OF CYCLE GROUPS OF HYDROGEN-BONDED WATER

MOLECULES .By G. E. Bass 345 PROTON MAGNETIC RESONANCE STUDIES OF PORPHYRIN IRON (III) CYANIDES .

By K. Wuthrich, R. G. Shulman, B. J. Wyluda, and W. S. Caughey 636 23NA NUCLEAR MAGNETIC RESONANCE RELAXATION STUDIES OF SODIUM ION INTER-

ACTION WITH SOLUBLE RNA . . By Thomas L. James and Joseph H. Noggle 644 FLEXIBILITY OF SUPPOSED 'RIGID" MOLECULES: SUBSTITUTED 2, 5-PIPERAZINEDIONES

(DIKETOPIPERAZINES) . By E. Benedetti, P. Corradini, M. Goodman, and C. Pedone 650 SYNTHESIS OF A MODEL SYSTEM FOR THE PRIMARY ENERGY CONVERSION REACTIONS IN

PHOTOSYNTHESIS .By Jui H. Wang 653 ON THE MECHANISM OF RIBONUCLEASE ACTION .By D. A. Usher 661 TOTAL SYNTHESIS OF THE RACEMIC FORM OF THE SECOND JUVENILE HORMONE (METHYL

12-HOMOJUVENATE) FROM THE CECROPIA SILK MOTH

By William S. Johnson, Simon F. Campbell, A. Krishnakumaran, and Andre S. Meyer 1005

GEOLOGY

A NEW CHROOCOCCACEAN ALGA FROM THE PROTEROZOIC OF QUEENSLAND . By Gerald R. Licari, Preston E. Cloud, Jr., and W. D. Smith 56

PROTEROZOIC EUCARYOTES FROM EASTERN CALIFORNIA . By P. E. Cloud, Jr., G. R. Licari, L. A. Wright, and B. W. Troxel 623

BIOLOGICAL SCIENCES

BOTANY

STUDIES ON THE DISTRIBUTION AND PROPERTIES OF A NEW CLASS OF CELL DIVISION-

PROMOTING SUBSTANCES FROM HIGHER PLANT SPECIES

. By Henry N. Wood, Armin C. Braun, Hans Brandes, and Hans Kende 349 INTERFERENCE OF MOONLIGHT WITH THE PHOTOPERIODIC MEASUREMENT OF TIME BY

PLANTS, AND THEIR ADAPTIVE REACTION . . By Erwin Buinning and Ilse Moser 1018

ZOOLOGY

ORGAN-SPECIFIC ESTROGEN-INDUCED RNA SYNTHESIS RESOLVED BY DNA-RNA HYBRIDIZATION IN THE DOMESTIC FOWL.

. By William E. Hahn, 0. A. Schjeide, and Aubrey Gorbman 112 MATERNAL AND EMBRYONIC CONTRIBUTIONS TO THE FUNCTIONAL MESSENGER RNA OF

EARLY DEVELOPMENT .By Marco Crippa and Paul R. Gross 120 FORMATION OF NEUROMUSCULAR JUNCTIONS IN EMBRYONIC CELL CULTURES .

. By Yutaka Shimada, D. A. Fischman, and A. A. Moscona 71a ON POPULATION GROWTH IN A RANDOMLY VARYING ENVIRONMENT

.By R. C. Lewontin and D. Cohen 1056 THE EFFECT OF RANDOM VAVRIATIONS OF DIFFERENT TYPES ON POPULATION GROWTH .

By R. Levins 1061 DEVELOPMENTAL PHASES OF THE BIOCOENOSIS .By Clyde E. Goulden 1066

PHYSIOLOGY

REGULATION OF TASTE ACUITY BY THIOLS AND METAL IONS

.By R. I. Henkin and D. F. Bradley 30 RATES OF POLYPEPTIDE CHAIN ASSEMBLY IN LIVER in vivo: RELATION TO THE

MECHANISM OF TEMPERATURE ACCLIMATION IN Opsanus tau .By Audrey E. V. Haschemeyer 128

AN ELECTROPHYSIOLOGICAL ANALYSIS OF THE ACTION OF CARBOHYDRATES ON THE

SUGAR RECEPTOR OF THE BLOWFLY . . . By Elizabeth Omand and V. G. Dethier 139

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CON TEN'S iii

STIMULATION OF C14-MELATONIN SYNTHESIS FROM C14-TRYPTOPHAN BY NORADRENALINE IN RAT PINEAL IN ORGAN CULTURE.

. By Julius Axelrod, Harvey M. Shein, and Richard J. Wurtman 544 NEURONAL DYNAMICS AND AXONAL FLOW, IN. BLOCKAGE OF INTRA-AXONAL ENZYME

TRANSPORT BY COLCHICINE .By Georg W. Kreutzberg 722 STUDIES ON MEMORY: EVIDENCE FOR A WIDESPREAD MEMOR,Y TRACE IN THE

NEOCORTEX FOLLOWING SUPPRESSION OF RECENT MEMORY BY PUROMYCIN

.By Josefa B. Flexner and Louis B. Flexner 729 ON TUNING AND AMPLIFICATION BY LATERAL INHIBITION.

.By Floyd Ratliff, B. W. Knight, and Norma Graham 733 RELEASE OF NEWLY SYNTHESIZED DOPAMINE FROM 1)OPAMINE-CONTAINING TERMINALS

IN THE STRI2ATUM OF THE RAT. . By M. J. Besson, A. Cheramy, P. Feltz, and J. Glowinski 741

INCORPORATION OF 14C-TRYPTOPHAN INTO 14C PROTEIN BY CULTURED RAT PINEALS:

STIMULATION BY 1-NOREPINEPHRINE.

By Richard J. Wurtman, Harvey M. Shein, Julius Axelrod, and Frances Larin 749 OLFACTORY BULB REMOVAL: EFFECTS ON BR1AIN NOREPINEPHRINE . . By Larissa

A. Pohor ecky, Michael J. Zigmond, Lennart Heimer, and Richard J. Wurtman . . 1052

MICROBIOLOGY

A "LEPORE" TYPE OF HYBRID -y GLOBULIN.

.By H. G. Kunkel, J. B. Natvig, and F. G. Joslin 144 INCORPORATION OF BRANCHED-CHAIN FATTY ACIDS INTO MYXOVIRUSES.

.By Herbert A. Blough and John M. Tiffany 242 PASSIVE HEMOLYSIS BY SERUM AND COBRA VENOM FACTOR: A NEW MECHANISM

INDUCING MEMBRANE DAMAGE BY COMPLEMENT . By R. J. Pickering, M. R. Wolfson, R. A. Good, and H. Gewurz 521

ANIRUS-SPECIFIC NUCLEIC ACIDS IN SV40-EXPOSED HAMSTER EMBRYO CELL LINES:

CORRELATION WITH S AND T ANTIGENS . By Myron J. Levin, Michael N. Oxman, George Th. Diamandopoulos, Arthur S. Levine, Patrick H. Henry, and John F. Enders 589

D-AMINO ACID OXIDASE IN LEUKOCYTES: A POSSIBLE D-AMINO ACID LINKED

ANTIMICROBIAL SYSTEM .By Martin J. Cline and Robert I. Lehrer 756 ACTIVE TRANSPORT OF MAGNESIUM IN Escherichia coli. . . . By Simon Silver 764 FURTHER STUDIES ON THE ROLE OF CIRCULATING LYMPHOCYTES IN THE INITIATION OF

PRIMARY ANTIBODY RESPONSES TO DIFFERENT ANTIGENS.

.By S. Strober and L. W. Law 1023 "RESCUED" SV40: INCREASED TRANSFORMING EFFICIENCY IN MOUSE AND HUMAN

CELLS .By George J. Todaro and Kenneth K. Takemoto 1031 THE ROLE OF INDIVIDUAL SPLEEN CELLS IN THE INTERFERON RESPONSE OF THE INTACT

MOUSE .By June E. Osborn and Duard L. Walker 1038 VIRUS-INDUCED SARCOMA OF MICE: INHIBITION BY A SYNTHETIC POLYRIBONUCLEOTIDE

COMPLEX.

By P. S. Sarma, Grace Shiu, R. H. Neubauer, S. Baron, and Robert J. Huebner 1046

PSYCHOLOGY

AUTORADIOGRAPHIC D)EMONSTRATION OF BIOCHEMICAL CHANGES IN THE LIMBIC SYSTEM

DURING AVOIDANCE TRAINING.

. By Garnet Beach, Michael Emmens, Daniel Porter Kimble, and Marvin Lickey 692 RELATIONSHIP OF SLEEP, RESPIRATION, AND ANESTHESIA IN THE PORPOISE: A PRE-

LIMINARY REPORT. By James G. McCormick 697

BIOCHEMISTRY

CHROMOSOMAL RECEPTOR FOR A VITAMIN D METABOLITE.

.By Mark R. Ilaussler and Anthony W. Norman 155

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iv CONTENTS

ANTIBODIES TO A UNIQuE REGION IN LYSOzYME PROVOKED BY A SYNTHETIC ANTIG EN

CONJUGATE. By Ruth Arnon and Michael Sela 163 ON THE CONFORMATIONAL INSTABILITY OF IhUMAN SERUM LoW-DENSITY LIPOPROTEIN:

EFFECr OF TEMPERATURE . . By A. Scanu, H. Pollard, R. Hirz, and K. Kothary 171 REVERSIBLE THERMAL CONFORMATION CHANGES IN HUMAN SERUM LOW-DE1NSITY

LIPOPROTEIN. By Dorr G. Dearborn and D. B. Wetlaufer 179 PROPEJRTIES OF NUCLEAR RNA IN SEA URCHIN EMBRYOS.

e . . . . By Arthur I. Aronson and Fred H. Wilt 186 GEN14 EXPRESSION IN INTERSPECIFIC HYBRIDS, I. DNA SYNTHESIS IN THE LETHAL

CROSS Arbacia lixula e1 X Paracentrotus lividus 9 . By H. Denis and J. Brachet 194 DIFFERENCES IN LEUCYL-TRANSFER RNA'S AND SYNTHETASE IN SOYBEAN SEEDLINGS .

.By Marianne Bieniek Anderson and Joe H. Cherry 202 ELECTRON MICROSCOPY OF THE CIRCULAR KINETOPLASTIC DNA FROM Trypanosoma

cruzi: OCCURRENCE OF CATENATED FORMS . . By Guy Riou and Etienne Delain 210 THE CYTOPLASMIC RNA OF HELA CELLS: NEW DISCRETE SPECIES ASSOCIATED WITH

MITOCHONDRIA. By Cesare Vesco and Sheldon Penman 218 INTERRELATION BETWEEN ACTIVATION AND POLYMERIZATION IN GRAMICIDIN S

BIOSYNTHESIS . . . By Horst Kleinkauf, Wieland Gevers, and Fritz Lipmann 226 a-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE

PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY

PHOSPHORYLATION AND DEPHOSPHORYLATION . By Tracy C. Linn, Flora H. Pettit, and Lester J. Reed 234

SYNTHESIS AND INDUCTION OF TYROSINE AMINOTRANSFERASE IN SYNCHRONIZED

HEPATOMA CELLS IN CULTURE

By David Martin, Jr., Gordon M. Tomkins, and Daryl Granner 248 THE TRANSCRIBING STRANDS OF Bacillus subtilis DNA FOR RIBOSOMAL AND TRANSFER

RNA .By M. Oishi 256 TEMPERATURE OF COMPENSATION: SIGNIFICANCE FOR VIRUS INACTIVATION .

. By Richard Barnes, Helmut Vogel, and Irving Gordon 263 HYBRIDIZATION OF CHROMOSOMAL RNA TO NATIVE DNA.

. By Isaac Bekhor, James Bonner, and Grace Kung Dahmus 271 INSULIN BIOSYNTHESIS IN THE RAT: DEMONSTRATION OF TWO PROINSULINS .

.By Jeffrey L. Clark and Donald F. Steiner 278 DONOR-ACCEPTOR INTERACTIONS OF NITROGEN.

.By J. E. Kimura and A. Szent-Gyorgyi 286 ENZYMATIC CLEAVAGE AND REPAIR OF TRANSFORMING DNA.

.By P. J. Laipis, B. M. Olivera, and A. T. Ganesan 289 THE CONDENSATION OF THE ADENYLATES OF THE AMINO ACIDS COMMON TO PROTEIN .

.By Gottfried Krampitz and Sidney W. Fox 399 THE FACILE ISOLATION OF A STRUCTURAL PHOSPHOLIPOPROTEIN FROM Hydrogenomonas

facilis AND Neurospora crassa .By Glenn D. Kuehn, Bruce A. McFadden, Roy A. Johanson, John M. Hill, and Lewis K. Shumway 407

A SPECIFIC ANTI-PROINSULIN SERUM AND THE PRESENCE OF PROINSULIN IN CALF SERUM

.By C. C. Yip and J. Logothetopoulos 415 STUDIES OF DNA-INFECTED DISRUPTED CELL PREPARATIONS.

By Bernard I. Weinstein, Roy P. Mackal, Betty Werninghaus, and E. A. Evans, Jr. 420 HYPERFINE STRUCTURE FROM THE FOUR PYRROLE NITROGENS OF HEME -

. . . . . . . . . . . . . . . By Charles P. Scholes 428 Azotobacter vinelandii RNA POLYMERASE, VII. ENZYME TRANSITIONS DURING UNPRIMED

r[I-C]SYNTHESIS .By J. S. Krakow, K. Daley, and M. Karstadt 432 GENEi, EXPRESSION IN INTERSPECIFIC HTYB3RIDS, II. RNA SYNTHESIS IN THE LETHAL

CROSS Arbacia lixula X Paracentrotus lividus 9 . By H. Denis and J. Brachel 438 THE RELATIONSHIP OF DNA REPLICATION TO THE CONTROL OF PROTEIN SYNTHESIS IN

PROTOPLASTS OF T4-INFECTED Escherichia coli B . By Kenneth J. Lembach, Akira Kuninaka, and John M. Buchanan 446

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CONTENTS v

TRANSLOCATION OF MRNA CODONS, I. The PREPARATION AND CHARACTERISTICS OF A

HOMOGENEOUS ENZYME .

By Philip Leder, Lawrence E. Skogerson, and Marion M. Nau 454 ON THE MFCHANISM OF CATALYSIS BY VITAMIN B12 . . . By Jonathan D. Brodie 461 A MUTANT OF YEAST APPARENTLY DEFECTIVE IN THE INITIATION OF PROTEIN SYNTHESIS

.By Leland H. Hartwell and Calvin S. McLaughlin 468 NUCLEOSIDEi, TRIPHOSPHAT'E POOLS AND THE REgGULATION OF RNA SYNTHESIS IN E. coli

.By G. Edlin and G. S. Stent 475 DNA-ID)EPENDENT RNA-DIRECTED PROTEIN SYNTHESIS in vitro, I. EXTENT OF GENOME

TRANSCRIPTION .By R. N. Bryan, M. Sugiura, and M. Hayashi 483 RELATIONSHIP BETWEEN NUCLEIAR GIANT-SIZE DRNA AND MICROSOMAL DRNA OF

RAT BRAIN .By James St6venin, Paul Mandel, and Monique Jacob 490 EVIDENCE FOR ONE FUNCTIONAL PHENYLALANYL TRNA BINDING SITE ON THE 30S

RIBOSOMAL SUBUNIT. By Kazuei Igarashi and Akira Kaji 498 COMPARATIVE HYBRIDIZATION OF MITOCHONDRIAL AND CYTOPLASMIC AMINOACYL

TRANSFER RNA WITH MITOCHONDRIAL D)NA FROM RAT LIVER.

.By Margit M. K. Nass and Clayton A. Buck 506 A TEMPLATE-SELECTIVE INHIBITOR OF in vitro TRANSCRIPTION

.By David L. Wilson and E. Peter Geiduschek 514 DNA-DIRECTED PEPTIDE SYNTHESIS, VI. REGULATING THE EXPRESSION OF THE Lac

OPERON IN A CELL-FREE SYSTEM. . . By Geoffrey Zubay and Muriel Lederman 550 THE ROLES OF SYNTHESIS AND DEGRADATION IN DETrERMINING TISSUE CONCENTRATIONS

OF LACTATE DEHYDROGENASE-5

. By Paul J. Fritz, Elliot S. Vesell, E. Lucile White, and Kenneth M. Pruitt 558 THE EFFECT OF TRNA CONCENTRATION ON THE RATE OF PROTEIN SYNTHESIS .

.By W. French Anderson 566 PHYSIOLOGICAL ROLE OF 70S RIBOSOMES IN BACTERIA .

By Israel D. Algranati, Nelida S. Gonzalez, and Ernesto G. Bade 574 STEREOCHEMICAL ANALYSIS OF THE SPECIFICITY OF PANCREATIC RNASE WITH

POLYFORMYCIN AS SUBSTRATE: DIFFERENTIATION OF THE TRANSPHOSPHORYLATION

AND HYDROLYSIS REACTIONS . . . . By D. C. Ward, W. Fuller, and E. Reich 581 A FLUORESCENCE PROBE OF ENERGY-DEPENDENT STRUCTURE CHANGES IN FRAGMENTED

MEMBRANES. By A. Azzi, B. Chance, G. K. Radda, and C. P. Lee 612 DEOXYRIBONUCLEASE IV: A NEW EXONUCLEASE FROM MAMMALIAN TISSUES .

. By Tomas Lindahl, Joseph A. Gally, and Gerald M. Edelman 597 STUDIES ON THE FORMATION OF TOBACCO MOSAIC VIRUS RIBONUCLEIC ACID, VIII.

FATE OF PARENTAL VIRAL RNA IN THE HOST CELL . . . . By K. K. Reddi 604 ROLE OF BASE-PAIRING IN THE CONTROL OF AN ENZYME REACTION.

.By Era Cassuto and Erwin Chargaff 808 THE USE OF AN ETHIDIUM ANALOGUE IN THE DYE-BUOYANT DENSITY PROCEDURE FOR

THE ISOLATION OF CLOSED CIRCULAR DNA: THE VARIATION OF THE SUPERHELIX

DENSITY OF MITOCHONDRIAL DNA

. By Bruce Hudson, William B. Upholt, Joseph Devinny, and Jerome Vinograd 813 THE ISOLATION OF TWO ENZYME-RIBONUCLEIC ACID COMPLEXES INVOLVED IN THE

SYNTHESIS OF FOOT-AND-MOUTH DISEASE VIRUS RIBONUCLEIC ACID

.By Ralph B. Arlinghaus and Jerome Polatnick 821 A NEW RIBONUCLEOTIDE REDUCTASE1 SYSTEM AFTER INFECTION WITH PHAGE T4 .

. By Ove Berglund, Olle Karlstrom, and Peter Reichard 829 PARTIAL CHARACTERIZATION OF THE RNA STIMULATING GROWTH OF THE SEMINAL

VETSICL1 .By T. Fujii and C. A. Villee 836 ALTERATION IN MICROSOMAL PROTEIN SYNTHESIS DURING EARLY DEVELOPMENT OF

MOUSE BRAIN. BY 'erry C. Johnson and Gail Belytschko 844 METACHROMATIC LEUKODYSTROPHY: ARYLSULFATASE-A DEFICIENCY IN SKIN

FIBROBLAST CULTURES . By Myna T. Porter, Arvan L. Fluharty, and Hayato Kihara 887 SYNTHESIS OF PHAGE-SPECIFIC a- AND fl-GLUCOSYL TRANSFERASES DIRECTED BY T-EVEN

DNA in vitro .By Lawrence M. Gold and Manfred Schweiger 892

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vi CONTENTS

DIFFERENCES IN THE TRANSFER RNA's OF NORMAL LIVER AND NOVIKOFF HEPATOMA . By B. S. Baliga, E. Borek, I. B. Weinstein, and P. R. Srinivasan 899

LOCAL STIMULATION OF GROWTH IN PRIMARY CULTURES OF CHICK EMBRYO FIBROBLASTS

.By T. Gurney, Jr. 906 THE STRUCTURE OF MOUSE-ELBERFELD VIRUS: A MODEL.

. By Roland R. Rueckert, A. Keith Dunker, and C. Martin Stoltzfus 912 REVERSIBLE TRANSFORMATION OF FIBROUS COLLAGEN TO A SOLUBLE STATE in vivo

.By LeRoy Klein 920 TRANSLOCATION OF MRNA CODONS, II. PROPERTIES OF AN ANTI-TRANSLOCASE

ANTIBODY . . . By Philip Leder, Lawrence E. Skogerson, and Donald J. Roufa 928 ENDONUCLEIASE II OF E. coli, I. ISOLATION AND PURIFICATION

.By Errol C. Friedberg and David A. Goldthwait 934 PRIMARY STRUCTURE, OF WHEAT GERM PHIE,NYLALANINE TRANSFER RNA .

* . . By Bernard S. Dudock, Gerson Katz, Ellen K. Taylor, and Robert W. Holley 941 THE MOLECULAR BASIS OF SUPPRESSIONS IN AN OCHRE SUPPRESSOR STRAIN POSSESSING

ALTERED RIBOSOMES .By T. Kent Gartner, Eduardo Orias, James E. Lannan, James Beeson, and Parlane J. Reid 946

DEHYDROALANYLLYSINE: IDENTICAL COOH-TERMINAL STRUCTURES IN THEi PEPTIDE

ANTIBIOTICS NISIN AND SUBTILIN.

.By Erhard Gross, John L. Morell, and Lyman C. Craig 952 A NEW CLASS OF LIPIDS: CHLOROSULFOLIPIDS.

By John Elovson and P. R. Vagelos 957 CRYSTALLIZATION OF DNA FROM DILUTE SOLUTION.

.By G. Giannoni, F. J. Padden, Jr., and H. D. Keith 964 AGE AND FLUORESCENCE CHARACTERISTICS IN SOME SPECIES OF ATHIORHODACEAE

. By H. de Klerk, Govindjee, M. D. Kamen, and J. Lavorel 972 THE DOMINANCE OF STREPTOMYCIN SENSITIVITY RE,-EXAMINE.D

.By Lee Breckenridge and Luigi Gorini 979 ON THE ASSOCIATION OF TYROCIDINE WITH ACETYLCHOLINESTERASE.

.By Jean-Pierre Changeux, Antoinette Ryter, Walo Leuzinger, Plana Barrand, and Thomas Podleski 986

A DIFFERENCE IN THE ARCHITECTURE OF THE SURFACE MEMBRANE OF NORMAL AND

VIRALLY TRANSFORMED CELLS .By Max M. Burger 994 ON THEI MECHANISM OF PE<PSIN ACTION . By T. Ralph Hollands and Joseph S. Fruton 1116 NEGATIVEI COOPERATIVITY IN REGULATORY ENZYMES.

.By Alexander Levitzki and D. E. Koshland, Jr. 1121 SOLUBILIZATION OF PARTICULATE PROTEINS AND NONELECTROLYTES BY CHAOTROPIC

AGENTS. By Y. Hatefi and W. G. Hanstein 1129 MULTIPLEI PHENYLALANYL-TRANSFER RIBONUCLEIC ACID SYNTHETASE ACTIVITIES IN

THE CYTOPLASM OF Neurospora crassa .By Frederick J. Kull and K. Bruce Jacobson 1137

TRANSFER RNA METHYLASEIS DURING MORPHOGE.JNESIS IN THEI CELLULAR SLIME;) MOLD

.By David Pillinger and Ernest Borek 1145 THE, MECHANISM OF ACTION OF RIBONUCLEASE. By Gordon C. K.

Roberts, Edward A. Dennis, Donella H. Meadows, Jack S. Cohen, and Oleg Jardetzky 1151 SUPERCOILED CIRCULAR DNA-PROTEIN COMPLEX IN Escherichia coli: PURIFICATION

AND INDUCED CONVERSION TO AN OPEN CIRCULAR DNA FORM

.By Don B. Clewell and Donald R. Helinski 1159 LOCATION OF SINGLE-STRAND INTERRUPTIONS IN THE DNA OF BACTERIOPHAGE T+ .

By Hermann Bujard 1167 ANTIBODIES TO ACETYLCHOLINESTERASE .By R. Michael Williams 1175 POLYPEPTIDE CHAIN INITIATION IN E. coli: ISOLATION OF HOMOGENEOUS INITIATION

FACTOR F2 AND ITS RELATION TO RIBOSOMAL PROTEINS

.By Yung-Bog Chae, Rajarshi Mazumder, and Severo Ochoa 1181 GIANT NUCLEOPLASMIC RNA IN THE SWITCH-ON OF COMPENSATORY RENAL GROWTH .

.By Margherita Willems, Hana A. Musilova, and Ronald A. Malt 1189

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CONTENTS vii

SPIN-LABIW1L:E,D TRANSFIER RNA

By Brian M. Hoffman, Peter Schofield, and Alexander Rich 1195 TRANSFEIR RNA, III. R1ECONSTITUTION OF ALANINIE ACCEPTOR ACTIVITY FROM

FRAGMENTS PRODUCED BY SPECIFIC CLEAVAGE OF TRNAIAa AT ITS ANTICODON . By Nobumasa Imura, Harvey Schwam, and Robert W. Chambers 1203

REGULATORY EFFECTS OF SUBSTRATES ON A PHOSPHOTRANSFERASEI FROM Aerobacter aerogenes AND THE MODIFICATION OF ITS ACTIVITY BY PARTIAL PROTEOLYSIS .

.By S. Schaefler and I. Schenkein 1210 THE INTIERACTION OF RNA POLYMERASE WITH HISTONES.

By Thomas C. Spelsberg, Sharon Tankersley, and Lubomir S. Hnilica 1218 ISOLATION OF A CHLORAMPHENICOLRIE,SISTANT PROTEIN FROM X-INFECTED CELLS

.By Arnold J. Levine and Robert L. Sinsheimer 1226 LEUCINI", tRNA AND Ci.SSATrION OF Escherichia coli PROTEIN SYNTHESIS UPON PHAGiF: T2

INFEcTION .By Tamiko Kano-Sueoka and Noboru Sueoka 1229

APPLIED BIOLOGY

SE1-.RUM-MEDIATE,D PROTECTION OF NiE,OPLASTIC CELLS FROM INHIBITION BY

LYMPHOCYTES IMMUNEI TO THEIR TUMOR-SPECIFIC ANTIGENS

.By Ingegerd Hellstrom, Karl Erik Hellstr6m, Charles A. Evans, Gloria H. Heppner, George E. Pierce, and James P. S. Yang 362

MEDICAL SCIENCES

EFFECT OF SEX HORMONES, ON THE SERUM-INDUCED THROMBOSIS PHENOMEiNON

.By Solange Amos, K. Odake, Clara M. Ambrus, and J. L. Ambrus 150 INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACID

. By Hilton B. Levy, Lloyd W. Law, and Alan S. Rabson 357 SELECTIVE DESTRUCTION OF ADRENAL CORTEX BY PULSE DOSES OF DERIVATIVES OF

12-METHYLBENZ(a) ANTHRACENEI.

.By Charles Huggins, Sotokichi Morii, and John Pataki 704 ULTRAVIOLET LIGHT ALTERATION OF CELLULAR DEJOXYRIBONUCLEIC ACID in vivo .

.By Eng M. Tan and Richard B. Stoughton 708 SURFACE-SPECIFIC CHARACTERISTICS OF A CONTACT-INHIBITED CELL LINE CONTAINING

THE SV40 VIRAL GENOME .By Robert E. Pollack and Max M. Burger 1074 COMPLEX MITOCHONDRIAL DNA IN LEUKE:MIC AND NORMAL HUMAN MYELOID CELLS

.By David A. Clayton and Jerome Vinograd 1077

GENETICS

GENETIC EVOLUTION OF BACTERIOPHAGEI, I. HYBRIDS BETWEEIN UNRELATED

BACTERIOPHAGES P22 AND Fels 2 . .By Nobuto Yamamoto 63 LINKAGIE, AN]) SEXLEICTION: NEW EQUILIB3RIUM PROPERTIES OF THJ,E TWO-LOCUS

SYMMETRIC VIABILITY MODEIiL . . By Samuel Karlin and Marcus W. Feldman 70 ARTIFICIAL AND NATURAL SIELErCTION FOR TWO BEHAVIORAL TRAITS IN Drosophila

pseudoobscura .By Theodosius Dobzhansky and Boris Spassky 75 FEEDBACK INHIBITION OF THE DEVELOPMENT OF MACROPHAGE AND GRANULOCYTE"J

COLONIE'S, II. INHIBITION BY GRANULOCYTES.

.By Michael Paran, Yasuo Ichikawa, and Leo Sachs 81 HYBRIDIZATION OF HAMSTER CELLS WITH HIGH AND LOW FOLATE REDUCTASiF: ACTIVITY

.By John W. Littlefield 88 INFORMATIONAL TRANSFER IN ME'IOTIC G1.NE: CONVERSION

.By S. Fogel and R. K. Mortimer 96 NUCLEAR GENE CONTROL OF MITOCHONDRIAL MALIC DEHYDROGENASE IN MAIZE .

.By Giovanna P. Longo and John G. Scandalios 104

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viii CONTENTS

TEMPERATURE-SENSITIVE MUTATIONS IN Drosophila melanogaster, III. DOMINANT LETHALS AND SEMILETTHALS ON CHROMOSOME 2.

.By David T. Suzuki and Douglas Procunier 369 CELL KINETIC STUDIES IN MIXED LEUKOCYTE CULTURES: AN in vitro MODEL OF

HOMOGRAFT REACTIVITY. By Fritz H. Bach, Harvey Bock, Kenneth Graupner, Elizabeth Day, and Heidi Klostermann 377

THE MOLECULAR ORIGIN OF LAMBDA PROPHAGE MRNA .By P. D. Bear and A. Skalka 385

RESTRICTED REJOINING OF CHROMOSOMAL SUBUNITS IN ABERRATION FORMATION: A TEST FOR SUBUNIT DISSIMILARITY . . . . By J. G. Brewen and W. J. Peacock 389

INCREMENT OF AVERAGE FITNESS FOR MULTIPLE ALLELES. . . . . By C. C. Li 395 DOSAGE COMPENSATION FOR ENZYME ACTIVITIES IN Drosophila melanogaster

. By Robert L. Seecof, William D. Kaplan, and David G. Futch 528 THE PURINE REQUIREMENT OF CELLS CULTURED FROM HUMANS AFFECTED WITH

THE LESCH-NYHAN SYNDROME (HYPOXANTHINE-GUANINE PHOSPHORIBOSYL- TRANSFERASE DEFICIENCY) . . . . By Jeanette S. Felix and Robert DeMars 536

MUTANTS IN Escherichia coli RIBOSOMES: A NEW SELECTION.

.By S. L. Phillips, D. Schlessinger, and D. Apirion 772 GENIC VARIATION IN A NATURAL POPULATION OF Drosophila persimilis

By Satya Prakash 778 INHERITANCE OF NITRATE-REDUCTASE ACTIVITY IN Zea mays L.

. By Robert L. Warner, R. H. Hageman, J. W. Dudley, and R. J. Lambert 785 EVIDENCE FOR INTERGENIC COMPLEMENTATION IN HYBRID CELLS DERIVED FROM TWO

HUMAN DIPLOID STRAINS EACH CARRYING AN X-LINKED MUTATION

.By Marcello Siniscalco, Harold P. Klinger, Harry Eagle, Hilary Koprowski, Wilfred Y. Fujimoto, and J. Edwin Seegmiller 793

THE PROTEINS OF BACTERIOPHAGE M13 . . By Timothy J. Henry and David Pratt 800 A QUANTITATIVE COMPARISON OF FORMATION OF SPONTANEOUS AND VIRUS-PRODUCED

VIABLE HYBRIDS .By Hayden G. Coon and Mary C. Weiss 852 SUPPRESSION OF HEAVY AND LIGHT CHAIN ALLOTYPIC EXPRESSION IN HOMOZYGOUS

RABBITS THROUGH EMBRYO TRANSFER . . By Gary S. David and Charles W. Todd 860 CYTOCHEROME OXIDASE DEFICIENCY IN WILSON'S DISEASE: A SUGGESTED

CERULOPLASMIN FUNCTION . . By M. K. H. Shokeir and D. C. Shreffler 867 A MUTANT OF Escherichia coli PERMITTING REPLICATION OF TWO F FACTORS .

.By W. K. Maas and A. D. Goldschmidt 873 ORIGIN AND DIRECTION OF DNA SYNTHESIS IN E. coli B/r.

.By C. B. Ward and D. A. Glaser 881 HYBRIDIZATION OF TWO BIOCHEMICALLY MARKED HUMAN CELL LINES.

.By Selma Silagi, Gretchen Darlington, and Sarah A. Bruce 1085 EVENTS OCCURRING DURING THE REPLICATION OF BACTERIOPHAGE T4 DNA .

.By Paul D. Scotti 1093 THE L-ARABINOSE OPERON IN Escherichia coli B/r: A GENETIC DEMONSTRATION OF

TWO FUNCTIONAL STATES OF THE PRODUCT OF A REGULATOR GENE

.By Ellis Englesberg, Craig Squires, and Frank Meronk, Jr. 1100 HEPATITIS AND AUSTRALIA ANTIGEN: AUTOSOMAL RECESSIVE INHERITANCE OF

SUSCEPTIBILITY TO INFECTION IN HUMANS. By B. S. Blumberg, J. S. Friedlaender, Anita Woodside, A. I. Sutnick, and W. T. London 1108

ERRATUM

GENETIC AND ANTIGENIC STUDIES AND PARTIAL PURIFICATION OF A HUMAN SERUM LIPOPROILEIN CARRYING THE LP ANTIGENIC DETERMINANT

. .B. I . . . . ]3y Jane S. Schultz, D. C. ShrefJler, and Nancy R. Harvie 2.97

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