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Preliminary Remarks
• Nonlinear ODEs do not usually have closed form solutions
• Numerical solutions are needed
• Qualitative analysis: phase plane analysis, bifurcation analysis,stability of steady states
• XPPAUT can do all that for us! FOR FREE!
Focus of this presentation:
We will use XPPAUT for solving :
-FitzHugh-Nagumo model of excitable membrane
-Population growth model with time delay
-Model of intracellular Calcium regulation
Fitzhugh-Nagumo Neuron[2 & 3.p161-163 & 4.p422-431]
• Simple model of an excitable membrane:
cell theinto injectedCurrent I
variableGatingw
potential MembraneV
).(
.)).(.(.
applied
wVdt
dw
IwCVVVBdt
dVapplied
Population Growth Model[3.p2-9]
• Simple model of growth:
•
capacity talEnvironmenk
growth ofconstant Rate
)/1(
r
kNrNdt
dN
Introduction of Time Delay
• No closed-form solution available • Dynamic is more interesting
signal.
inhibitory ofn propagatiofor delay Time
)/)(1(
T
kTtNrNdt
dN
Calcium RegulationProc.Natl.Acad.Sci. U.S.A. (1990) 78,1461-1465
cytosol into vesiclesER fromleak Calcium
membrane plasman through eliminatio Calcium
ER from release Calcium induced CalciumJRyR
. pump calciumdependent ATP
ER. from release calcium induced 3
spacelar extracellu from cytosol intoleak Calcium0
][
][.
][
][,
][
][2
][][
][][]3.[0][
5
4
1
44
4
22
2
3222
2
5
541
k
k
pump
IPv
v
CaK
Ca
CaK
CavJRyR
CaK
Cavpump
CakJRyRpumpdt
Cad
CakCakJRyRpumpIPvvdt
Cad
AERR
ER
ERER
ER
Role of IP3( )
• Base parameter values are:
sMv /10
sMv /3.71
M 0
sMv /652
MK 12
sMv / 5003
MKR 2
MK A 9.0
14 10 sk
15 1 sk
Conclusion
• XPPAUT is a powerful tool for:
• Solving ordinary and delay differential equations
• Understanding the solution through bifurcation analysis.
References
• [1] Goldbeter,A.,Dupont,G., and Berridge,M.(1990). Proc.Natl.Acad.Sci.U.S.A. 87 1461-1465.
• [2] FitzHugh,R.(1961).Biophys J.1,445-466• [3] Murray J.(1989) .Mathematical Biology,1st
edition,Springer-Verlag,New York.• [4] Fall,C, et al,(2002) Computational Cell
Biology,1st edition,Springer-Verlag,New York• [5] Bard Ermentrout XPPAUT5.41 Differential
equations tool(August,2002)• www.math.pitt.edu/~bard/xpp/xpp.html