Zo Training Module

Comprehensive Skin Health Solutions

Beverly Hills

ZO® Skin Health Difference

“Making Healthy Skin Possible for Every Patient”

From Zein Obagi, MD

• Proven track record of skin care innovations spanning over 35 years

• Thought leader and pioneer behind Skin Health Circle paradigm

• Creator of # 1 brand of RX anti-aging skin care

• Visionary and founder of ZO® SKIN HEALTH

• Leader in dermatology treatments for different ethnicities

• Board Certified Dermatologist

• World-renowned authority, lecturer, innovator and educator

4

The Vision

Develop and market ZO® Skin Health as the only complete source of world-class skincare products and solutions.

Provide results-oriented solutions tailored to meet the specific needs of every person at every age and every stage in their life.

Deliver clinically proven results that correct and maintain healthy skin that is strong, smooth and firm, evenly toned, fully hydrated and free of disease.

Brand Name Recognition

ZO® Skin Health Difference

The Science and Theory

Age, genetics, environmental influences (UV polutants), diet, stress, hormones, sleep and skin care:all play a role. A balanced lifestyle and effective skin care, can restore healthy skin. Dr. Obagi defines the difference between healthy skin and damaged skin as follows:

Healthy Skin Elements Damaged Skin Elements

Texture Smooth Rough

Moisture Hydrated Dry

Strength Tight/Firm Loose and weak with fine lines

Tone Even Tone Discoloration (dark spots, rosacea)

Volume Full Lax

Disease Free of active disease Presence of active disease

Skin Tolerance Strong/Tolerant Sensitive

Healthy Skin vs. Damaged Skin

Age Appearance Physiology

< 15 Nearly perfect skin.

Smooth texture, pores small.

Excellent repair capabilities.

Low sebaceous gland activity.

Skin hydration good.

15 - 25 Acne key factor in surface texture. Fine lines start to appear, pore size increasing

High sebaceous gland activity.

Mild drop in dermal repair, immune system and collagen synthesis.

Strong cohesion between skin layers and rapid cell turnover.

Small drop in skin hydration, noticed particularly in winter.

25 - 45 More fine lines and appearance of first wrinkles Early signs of sagging near the eye.Some loss of elasticity. Adult acne.

Moderate decrease in dermal repair, resulting in less collagen and increasing accumulation of damaged corrective tissue. Noticeable and significant drop in skin hydration.

45 - 55 More wrinkles, rough texture. Sallow yellow color Pores, age spots enlarge and define. Sagging near eye and cheek.

Significant decrease in dermal repair and immune system. Continued dermal degradation. Cohesion between skin layers continues to decline. Thinning of epidermis and stratum corneum. Skin tends now to be dry.

55 + Wrinkles and fine lines in abundance.

Uneven color, pigmentation. Sagging worsens. Dark circles under eye.

Compromised dermal repair, abundance of damaged connective tissue. Low production of collagen and sebum. Increased local over-production of melanin.

Skin Aging

EPIDERMISThis is the outer protective, non vascular layer of the skin.

DERMISThe dermis consists mostly of connective tissue and is much thicker than the epidermis.

SUBCUTANEOUS LAYER

The subcutaneous layer below the dermis consists of loose connective tissue and much fat. It acts as a protective cushion and helps to insulate the body by monitoring heat gain and heat loss.

Science & Theory

THE GOALS

Stabilization

•Maintain even skin tone

•Prevent future potential for hyperpigmentation

•Stabilize melanocytes for pigment control

Activate and Stimulate Cellular Function

•Exfoliate dead surface cells

•Activate new cell production

•Increase collagen production

Improve overall appearance

•Smooth texture

•Tight pores

•Firmness and density

THE TOOLS

Zo Skin Health Products are the Tools!

Using these tools is not a new concept, how they are used is….

Combining these tools into programs that use high concentrations of active

ingredients in protected delivery systems, ZO Skin Health can deliver the most

targeted, effective, sustainable results on the market today.

Tool Drivers:

Peptides: a molecule formed by joining two or more amino acids

Enzymes: increase the rate of a reaction

Antioxidants: inhibit the oxidation of other molecules

Retinol: accelerates cell turnover and collagen production

Cellular Function

• ZO® Skin Health works at the cellular level so that skin nourishes, repairs and maintains itself.

• Anti-oxidants (Vitamins C & E, Coenzyme Q10) neutralizes free radicals to help reverse the signs of aging.

• ZO® Skin Health Programs help to achieve optimum skin health by “layering” protected retinol, anti-oxidants and vitamins to increase and enhance repair.

• Dr. Obagi recommends a 5-step targeted program approach.

Microsponge• The Microsponge Delivery System (MDS) is a unique technology for the controlled

release of topical agents

• Consists of macroporous beads, typically 10-25 microns in diameter, loaded with active agent

• When applied to the skin, the MDS releases its active ingredient on a time mode and also in response to other stimuli (rubbing, temperature, pH, etc)

• MDS technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products

• By delivering the active gradually to the skin, MDS-retinol, for example, has excellent efficacy with minimal irritation

Clinical Study: Journal of Dermatological Treatment (2000) LH Kligman and EH Gans

Once abandoned because of its instability, ROL can now be sequestered in Microsponge Polymers with low irritancy and cosmetic acceptability for treating the visible signs of aging and photoaging. Protected from oxidation by antioxidants such as vitamins C and E, it remains stable with a shelf life of at least 2 years. By obviating the rapid degradation that ROL would otherwise undergo, the new formulation has permitted the resumption of research with this agent. It was found that ROL was metabolized primarily to retinyl esters and to relatively small amounts of RA which activated nuclear RA receptors. ROL can be effective in inducing beneficial epidermal changes with less irritation than RA. **1.6% ROL induced significant epidermal thickening similar to that of 0.025% RA. Trace erythema, occurred with ROL whereas RA induced measurable erythema. ROL penetration was more effective than that of RA, but required a 10-fold higher concentration than RA. ROL increased epidermal thickness without the erythema induced by RA. Studies demonstrated that ROL has lower potency than RA, requiring higher concentrations than RA to produce similar epidermal effects. ROL is more effectively delivered into skin, inducing retinoid changes in the epidermis without irritation.

Clinical Study: Re-emergence of topical retinol in dermatology

Liposome

• Liposomes are minute spherical oil droplets separated from an aqueous medium by a phospholipid bilayer

• The small size of liposomes enables them to pass through epidermis and act as a carrier for liquid substances, which are enclosed within the liposome’s hollow internal cavity

EnzymesAn enzyme is a protein molecule that is a biological catalyst with three characteristics:

1.The basic function of an enzyme is to increase the rate of a reaction. Most cellular reactions occur about a million times faster than they would in the absence of an enzyme.

2.Most enzymes act specifically with only one reactant (called a substrate) to produce products.

3.Enzymes are regulated from a state of low activity to high activity and vice versa.

Peptides• Peptide is a molecule formed by joining two or more amino acids

• They have the same peptide bonds as those in proteins, but are shorter in length • Peptides are named based on the number of amino acids in the chain: dipeptides (2),

tripeptides (3), tetrapeptides (4), pentapeptides (5) • When the number of amino acids is less than 50 these molecules are named peptides

while larger sequences are referred to as proteins • A peptide bond is a special linkage in which the nitrogen atom of one amino acid binds

to the carboxyl carbon atom of another

• Matrixyl 3000 uses tetrapeptide (4) and oligopeptides (2-20) to minimize wrinkles and a lifting effect

Lipopeptides• Lipopeptide is a peptide attached to a lipid (fat)

• Lipopeptides have been shown in scientific studies, to boost cell's natural productivity levels

• Considered to be one of nature's most powerful anti-agers by interacting with cell

membranes to boost natural function of the cells, renewing them to maximum growth potential.

• Surfactin is a biologically active lipopeptide and is predominantly a biosurfactant • It has received considerable attention with regard to its excellent surface cleansing

properties

Antioxidants• An antioxidant is a molecule capable of inhibiting the oxidation of other molecules

• Oxidation is a chemical reaction that transfers electrons or hydrogen from a substance to an oxidizing agent

• Oxidation reactions can produce free radicals, these free radicals start chain reactions

• When the chain reaction occurs in a cell, it can cause damage or death to the cell

• Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions

• Vitamin A is a key vitamin that the skin needs topically.

• Oxidizes easily and is unstable.

• Oral consumption does not address the topical deficiency.

• Application of stabilized Vitamin A, in sufficient levels, will give optimum benefits.

• Retinol at higher levels can cause irritation.

• Most OTC products do not deliver enough retinol to the skin.

• Needs a stabilized delivery system.

• ZO® uses an encapsulated delivery system that sends stabilized retinol in a time-released form, that reduces potential irritation.

Vitamin A

Retinol

• Retinol is considered one of the most effective anti-aging ingredients

• Natural form of Vitamin A

• Most effective over-the-counter vitamin for aging skin

• Improves overall skin health

• Able to go inside the cell to stimulate cellular function at the dermal level

• Simultaneously repairs damage at the epidermal level

Retinol

Benefits of regular use:

Reduces appearance of fine lines, wrinkles, sun damage and age spots

• Improves brightness and tone

• Increases collagen production, firmness and elasticity

• Retinol is preventative and corrective

Early use helps prevent fine lines, wrinkles, age spots and uneven tone

Later use of retinol will help correct visible signs of aging

Retinol Cascade

• The retinol cascade is the process where special enzymes convert retinol to retinoic acid

• The majority of over-the-counter skin care products have very low levels of retinol

• Products that have a low concentration of retinol produce less retinol cascade

• When the conversion rate is low, little retinoic acid becomes bio-available to the cells

• A high concentration of retinol increases the conversion rate of retinol-to-retinoic acid

Vitaine (Encapsulated Retinol)• A liposome containing 0.5% stabilized retinol

• Found in: Daily Power Defense, Intense Eye Repair, Daily Renewal Crème, Overnight Recovery Creme

• Liposomal delivery can increase retinol levels retained in the stratum corneum

• Liposome structure protects retinol from degradation

• Ratio of retinol to lipid is engineered to ensure maximum stability

• Retinol is carefully stacked in the liposome to protect from hydrolysis

• Liposome entrapment of retinol gives stability

Photosomes (DNA Repair)• Photosomes repair sun-induced damage to DNA

• Found in: Daily Renewal Crème

• Photosomes is photolyase in multilamellar liposomes

• Photolase is a light-activated marine enzyme

• Photolase is derived from photosynthetic plankton called Anacystis nidulans

• These liposomes are formed from pure egg phospholipids

• Photolyase absorbs visible light to directly adhere to and reverse short UV wavelength damage (uvb)

• Photosomes protect the cells of the skin’s immune system

• Photsomes are used at a 1% concentration

Oxysomes (antioxidants C and E)• Vitamin C and E together reduce free radical damage by 50%

• Found in: Daily Renewal Creme

• Oxysomes deliver vitamin C within 1 hour and increase bioavailability by 85%

• Vitamin C boosts collagen synthesis

• Internalized vitamin C protects the vitamin E

• UV-absorbing properties of vitamin E protects the photosensitivity of vitamin C

• Provides powerful antioxidant properties at a 1% concentration

• Contains: 2% VC-PMG (L-Ascorbic Phosphate Magnesium) derivative of L-ascorbic acid (vitamin C)

• Contains: 12% alpha-tocopherol (vitamin E)

Ultrasomes (DNA Repair)• Natural DNA repair activity is facilitated by endonuclease enzyme

• Ultrasomes are UV-endonuclease enzymes encapsulated in multilamellar liposomes

• Endonuclease recognizes UV damage and accelerates repair by 4 times

• Protects immune system by repairing UV-DNA damage

• Provides post exposure sun damage recovery

• Endonuclease is prepared from micrococcus luteus which is a bacterium found as part of the normal flora of the mammalian skin

• Liposomes are formed from pure egg phospholipids

• Ultrasomes are used at a 1% concentration

Roxisomes (DNA Repair)• Roxisomes repair DNA damage from free radicals generated by UVA sunlight

• Found in: Daily Power Defense

• Roxisomes shorten the time for nucleus DNA repair from 24 hours to 2 hours

• Roxisomes is the enzyme glycolase (8-oxo-guanine glycolase) in multilamellar liposomes

• Glycolase recognizes oxidative damage to DNA and initiates the repair process in the nucleus and mitochondria

• These liposomes are formed from pure egg phospholipids

• Glycolase naturally occurs in arabidopsis thaliana, a small flowering plant native to Europe, Asia and Africa that is used in molecular biology and light sensing

• Roxisomes are used at a 1% concentration

Phytopresome Q 10 (CoQ10)• CoQ10 (ubiquinone) is a powerful antioxidant

• Found in: Radical Night Repair

• Photopresome Q 10 provides stable liposomes containing Coenzyme Q 10

• Provides superior skin barrier function

• Supports collagen

• Penetration of CoQ10 is enhanced in liposome delivery

• Photopresome Q 10 is a lipid complex of phospholipids and sterols

Ceremides (fatty acids)• Rebuilds the skin barrier and increases barrier efficacy in 2 weeks

• Found in: Overnight Recovery Crème, Daily Power Defense

• Ceramides are a family of lipid molecules that are composed of fatty acids

• Ceramides are found in high concentrations within the membrane of cells

• Aging and environmental exposure diminishes the replenishment capacity of the skin

• Provides the skin with a bioavailable, biostabilized form of linoleic acid

• Protects overall skin integrity

• Anti-inflammatory

Matrixyl 3000 (collagen production)• These peptides act in synergy to restore collagen production stimulating

fibroblast cells enabling them to reduce the appearance of wrinkles

• Found in: Daily Power Defense, Intense Eye Repair

• Peptides are messengers of skin restructuration and repair. They activate the new synthesis of the extracellular matrix providing anti-wrinkle efficacy.

• As messenger molecules, peptides are capable of regulating cell activities.

• Matrixyl™ 3000 contains two peptides, Pal-GHK and Pal-GQPR (Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7). (Matrixyl contains only one peptide, Palmitoyl Penta ( Oligopeptide)

• Palmitoyl Tetrapeptide is a breakthrough ingredient which inhibits and reverses free radical damage.

•

Matrixyl 3000• Each component of Matrixyl™ 3000 has been shown to have distinct anti-aging benefits

• These peptides used in combination have a synergistic anti-aging effect

• Interaction with specific receptors activate certain genes in the process of extracellular matrix renewal and cell proliferation, with age these mechanisms become progressively weaker

• One is not inferior to the other, Palmitoyl Penta or Palmitoyl Tetrapeptide

• Each addresses different aspects of the skin aging process, used in combination they boost the power of each one

• Matrixyl 3000 is used in a 3% concentration

MDI Complex (protects collagen)• Inhibits the MMP enzymes that degrade and destroy collagen (matrix metalloproteinase)

• Found in: Intense Eye Repair, Overnight Hand Recovery

• MDI Complex (Glycosaminoglycans) inhibits 80% of MMP enzyme activity

• These enzymes (MMP) are activated with sun exposure, stress and environmental irritants

• Activity of these enzymes affects the health of the extracellular matrix

• Important to both preserve the matrix and maintain enzymatic equilibrium

• MDI Complex neutralizes excessive MMP activity

• Enzymatic equilibrium allows for greater skin elasticity and increased resistance to stress and environmental exposure

ZO® Skin Health Product Line

Cleanse | Activate | Stimulate | Calm + Nourish | Protect

Eye | Hand | Body

ZO® Five Step Approach

STEP 1 CLEANSETo enhance the effects and benefits of the following steps

STEP 2 ACTIVATETo increase the penetration of active ingredients,

STEP 3 STIMULATETo improve uneven pigmentation, reduce fine lines and wrinkles, reduce collagen degradation and improve the elasticity of the skin

STEP 4 CALM + NOURISHTo soothe and calm skin after the surface has been exfoliated and potent concentrations have been applied

STEP 5 PROTECTTo protect skin against future sun damage

ZO® Skin Health Programs

LEVEL I: DAILY SKINCARE PROGRAM

LITTLE OR NO apparent sign of chronological or photo agingOur Daily Skincare Program is an everyday skincare regimen to maintain healthy looking skin. These

basic tools have retinol and specialized enzymes to encourage cellular activity, repair damaged cells and

protect against future damage.

LEVEL II: ANTI-AGING PROGRAM EARLY signs of intrinsic aging – fine lines, uneven skin tone, loss of firmnessThis moderately aggressive program, with highly advanced anti-aging skincare tools, helps to repair andprevent damaged skin. Active ingredients, such as growth factors, retinol and specific enzymes assist in improving the cellular repair function and restoring the appearance of youthful, healthy skin.

LEVEL III: AGGRESSIVE ANTI-AGING PROGRAM

DEFINITE signs of aging skin – wrinkles, brown patches, loose skin, large pores,

obvious damage This aggressive program, using high concentrations of retinol, is for anyone with chronological and

environmental skin damage and skin aging concerns. Using these tools can help correct and rejuvenate

the skin, revealing radical improvement of wrinkles, fine lines, rough texture and sagging skin.

3 Level Kit Program …A SIMPLE SELLING STRATEGY

LEVEL I:

DAILY SKINCARE PROGRAM

NO apparent sign of chronological or photo aging

CLEANSE: Exfoliating Cleanser

ACTIVATE: Exfoliating Polish

STIMULATE: Daily Power Defense

PROTECT: Sunscreen Primer


LEVEL II:

ANTI-AGING PROGRAM

EARLY signs of intrinsic aging – fine lines, uneven tone, loss of firmness

CLEANSE: Exfoliating Cleanser


STIMULATE: Daily Power Defense (AM)

STIMULATE: Growth Factor Serum (PM)



LEVEL III:

AGGRESSIVE ANTI-AGING PROGRAM

DEFINITE signs of aging skin – wrinkles, brown patches, loose skin, large pores, obvious sun damage

CLEANSE: Hydrating Cleanser


STIMULATE: Daily Power Defense (AM)

STIMULATE: Radical Night Repair (PM)

CALM + NOURISH: Daily Renewal Crème


Step 1: Cleanse

Offects® Hydrating Cleanser

• Dual-action cleanser thoroughly cleans while it replenishes moisture with hyaluronic acid.

• Natural moisturizers Panthenol and Allantoin prevent over-drying, leaving skin fresh and clean.

• Advanced lipopeptides boost and maintain skin’s natural production of collagen.

• Cleanse every morning and evening.

• pH 6.5

• Size: 150 mL / 5 Fl. Oz.

$45.00 (USSRP)

Step 1: Cleanse

Offects® Exfoliating Cleanser

• Encapsulated beads of Vitamin E neutralize free radicals and nourish skin cells.

• Micro-beads exfoliate surface dull, dry skin cells.

• Advanced lipopeptides boost and maintain skin’s natural production of collagen.

• Cleanse every morning and evening.

• pH 6.0

• Size: 150 mL / 5 Fl. Oz.

$45.00 (USSRP)

Step 2: Activate

Offects® Exfoliating Polish

• Combines therapeutic minerals of the Dead Sea with the benefits of microdermabrasion.

• Magnesium crystals slough off dry skin, improve skin texture and help combat stress and fluid retention.

• Four vitamins (A, C, C-Ester & E) deliveranti-oxidant protection

• Natural exothermic reaction warms skin.

• Apply 2-3 times per week.

• Size: 65 g / 2 Oz.

$75.00 (USSRP)

Step 2: Activate

Offects® TE-Pads Acne Pore Treatment

• Controls skin breakouts.

• Reduces oiliness.

• Exfoliates pore-clogging dead skin cells.

• Contains 2% salicylic acid

• Botanical extracts calm and soothe.

• Apply 2-3 times per week.

• Size: 60 pads

• pH 3.5

$45.00 (USSRP)

Step 3: Stimulate

Ossential® Radical Night Repair Plus

Better than any other topical skincare:

• Reduces lines and wrinkles • Decreases hyperpigmentation • Increases skin thickness and elasticity • Accelerates cellular turnover, helps stimulate

collagen production

Named a Beauty Breakthrough Ossential® Radical Night Repair Plus

Why ZO®?

ZO® uses a 1.0% concentration of retinol

• For retinol to be topically effective, it must reach a concentration of at least 0.6% in the skin

• Currently, the strongest available over-the-counter retinol products are at a concentration of 0.21%

• The leading brand concentration is 0.15%

This is why the ZO® Skin Health Program approach of “layering” retinol delivers the needed amount of retinol to the skin.

Retinol Delivery System

Time-Released MicrospheresTraditional retinol products cause a sudden release and "downpour" of retinol—which can be irritating. That’s why manufacturers use a very low concentration of retinol.

ZO® Skin Health’s Radical Night Repair Plususes a unique delivery system–the retinol is encapsulated in a time-released microsponge. So unlike the "downpour", microspheres causes a slow, steady, continuous “drizzle”.

Anhydrous (water-free)formula increases the potency of active ingredients.

Antioxidants (Vitamins C & E, Co-Q10)

Skinasensyl® a peptide that increases skin’s natural tolerance threshold. Users are much less likely to experience any discomfort, which is especially beneficial to over-reactive and sensitive skin.

Dr. Obagi’s Recommended Regimen:

Olluminate Intensive Eye Repair can be added both AM and PM


PRODUCT AM PM

Offects® Hydrating Cleanser X X

Offects® Exfoliating Polish X

Ossential® Daily Power Defense X

Ommerse® Daily Renewal Creme X

Oclipse® Sunscreen + Primer SPF 30 X


X

Step 3: Stimulate


Usage

• Initially, Radical Night Repair Plus should be applied twice per week. After two weeks, increase to three times per week. After 6-8 weeks, apply nightly.

• This product is best used in combination with other products that complement it, and do not compete with it or irritate it.


Step 3: Stimulate


Step 3: Stimulate

Ossential® Daily Power Defense

• Advanced DNA repair complex features enzymes that initiate repair to increase cell survival, thereby reducing collagen degradation.

• Contains Ultrasomes with UV-endonuclease

• Contains Roxisomes with glycolase

• Uses the powerful anti-oxidant, vitamin E and retinol liposomes (Vitaine), to help correct and prevent damage caused by age and UV rays.

• Increases skin’s natural moisture barrier to help skin stay hydrated with Ceremide 6.

• Botanical extracts help soothe and calm.

• Lightweight serum leaves skin soft and smooth.

• Reduced appearance of fine lines and wrinkles.

• Increases epidermal thickness, firmness & elasticity.

• Apply every morning.

• pH 6.8

• Size: 30 mL / 1 Fl. Oz.

$175.00 (USSRP)

Step 3: Stimulate


Step 3: Stimulate

Ossential® Growth Factor Serum

• Synthetic growth factors.

• Advanced lipopeptides boost and support collagen to help firm and tone.

• Nanoemulsion™ penetration technology improves delivery.

• Proprietary lipopeptides are enhanced with anti-aging Vitamins A, B & C plus essential amino acids. These are the building blocks necessary to stimulate cell renewal and collagen production.

• Retinol reduces pigmentation and the appearance of fine lines and wrinkles.

• pH 6.5

Step 3: Stimulate


• Highly effective topical anti-aging therapy suitable for even the most sensitive skin types.

• Lightweight gel formula glides on easily.

• Apply every morning and evening.

• pH 6.5

• Size: 30 mL / 1.0 oz

$195.00 (USSRP)

Step 3: Stimulate


Clinicals (Kligman)

• Wrinkle Visibility (Superficial Facial Lines): Statistically significant reduction after Week 1 (10%) and increased to 33% by Week 8.

• Expert Grader Assessment of Improvement: High resolution digital photos revealed all twenty subjects demonstrated “moderately to very noticeable improvement”.

• Skin Texture: Skin roughness, pore visibility, hyper pigmented spots and blotchy/redness were significantly reduced from Week 2 on and these reductions reached between 20 - 25% at Week 8.

Step 3: Stimulate


Clinicals (Kligman)

• Skin Tautness and Elasticity: From Week 1 on, skin was significantly tauter and more elastic. At Week 8, skin was 28% tauter and 25% more elastic.

• Self Assessment (Diaries): All twenty subjects felt their skin was smoother and softer. Eighty percent perceived a reduction in wrinkles and sixty percent found their skin less oily and noticed a reduction in age spots. No one reported any dryness or peeling.

Step 4: Calm + Nourish

Ommerse® Daily Renewal Creme

• Hydrates with Hyaluronic Acid, Jojoba Esters and natural emollients like Coconut Oil.

• Soothes with an advanced anti-irritant complex that contains Oat and Canadian Willowherb Extracts to reduce skin inflammation.

•Contains Oxysomes and Vitaine (retinol)

• Protects with Ectoin, a multi-functional agent that protects against photo-aging, the formation of sunburn cells and induces faster formation of heat-shock proteins under stress.

•pH 6.8

• Size: 50 mL / 1.7 oz

$95.00 (USSRP)


Ommerse® Overnight Recovery Creme

• Hydrates the skin by creating a barrier that protects against trans-epidermal water loss with Ceramide 2, Soline, Squalane and Shea Butter to maintain optimum water levels.

• Repairs DNA damage caused by aging and sun exposure by using encapsulated enzymes called Ultrasomes (endonuclease) to increase cell survival

• Soothes, protects and reduces redness and inflammation with Canadian Willowherb and Evodia Fruit Extracts

• Encourages skin to look and feel healthy and luminous with encapsulated Retinol (vitaine)

•pH 5.5

• Size: 50 mL / 1.7 oz

$95.00 (USSRP)

Step 5: Protect

Oclipse® Sunscreen + Primer SPF 30

• Broad spectrum UVA/UVB protection with titanium dioxide (10.2%) and zinc oxide (3.7%), plus unique and superior antioxidant protection.

• Contains natural melanin

• Melanins are natural, photo-protective compounds which are excellent anti-oxidants and free radical quenchers.

• Increased melanin reduces incidence of skin cancer, photo-aging and photo-sensitive disorders.

• Silicone-based formula primes the skin for cosmetics application.


$65.00 (USSRP)

Step 5: Protect

Oclipse® Sunscreen + Primer SPF 30

The “smartest” sun-protection duo under the sun:

•Daily Power Defense DNA Repair

•Sunscreen Primer SPF 30

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Skin Cancer Prevention is Critical

500,000

new cases of skin cancer every year (US)

27,000

cases of malignant melanoma

80%of damage occurs before 18 years old

Melanin

• A natural skin pigment

• Single most important factor in the photo protection of the skin

• 10 times more powerful than Vitamin E

Specialty: Eye

Olluminate® Intense Eye Repair

• Dual action formula instantly reduces the appearance of fine lines and wrinkles while providing long-lasting results.

• Rich blend of time release retinol (Vitaine), advanced peptides and optical diffusers (mica and titanium dioxide) helps repair and diminish dark circles, fine lines and wrinkles.

• Cooling formula reduces puffiness and the appearance of yellow skin tone.

• Combination of Glycosaminoglycans, Vitamin E and Matrixyl 3000 protects against free radical damage and boosts skin’s natural collagen production.

• Apply every morning and evening.

• pH 6.2

• Size: 15 mL / .5 Fl. Oz.

$130.00 (USSRP)

• Sugar crystals exfoliate the skin, leaving it smooth, hydrated and super-soft.

• Retinol, an active form of Vitamin A, helps restore a youthful appearance.

• Shea butter moisturizes and leaves a light after-feel. Rinses easily.

• Massage at least once a week.

• Size: 30 g / 1.0 Oz.

$50.00 (USSRP)

Specialty: Hand

Oraser® Microderm Hand Renewal

Specialty: Hand

Oraser® Daily Hand Repair SPF 20

• Retinol reduces age spots and the look of deeper lines and wrinkles.

• Powerful vitamin E and anti-oxidants help neutralize damaging free radicals.

• Skin whiteners help normalize skin tone and reduce the appearance of age spots.

• Broad spectrum protection (avobenzone) against UVA (aging rays) and UVB (burning rays)


• pH 6.0

• Size: 100 mL / 3.4 Fl. Oz.

$65.00 (USSRP)

Specialty: Hand

Oraser® Overnight Hand Recovery

• A complex of retinol, vitamins and Coenzyme Q10 protects against the damaging effects

• of free radicals, thereby improving skin elasticity, firmness and tone.

• Vitamin C brightens the skin and boosts collagen synthesis.

• Natural emollients provide 8-hour barrier protection.

• Apply every evening.

• pH 6.0

• Size: 100 mL / 3.4 Fl. Oz.

$65.00 (USSRP)

Specialty: Body

Oraser® Body Emulsion

• Intense combination of Lactic Acid (11.5%), active Retinol and emollients lock in moisture and stimulate cell renewal.

• Anti-oxidant rich complex softens rough patches and strengthens skin’s natural moisture barrier.

• Lifts away the look of dark spots with natural extracts such as Glucosamine. Skin brighteners help normalize skin tone.

• Apply morning and evening.

• pH 3.7

• Size: 200 mL / 8.1 Fl. Oz.

$80.00 (USSRP)

Step 1: Cleanse

Product Name Ingredients & Benefits

Offects® Exfoliating Cleanser Gently remove impurities and repairs surface damage with:

Vitamin E encapsulated beads:• Neutralize free radicals and exfoliate dead skin cells Salicylic Acid •targets excess oil

Advanced Lipopeptide:• Boosts skin’s natural production of collagen

Offects® Hydrating Cleanser Gently remove impurities and repairs surface damage with:

Hyaluronic acid, Panthenol and Allantoin:• Lock in necessary moisture for a healthy complexion • Stimulate the growth of healthy tissue

Advanced Lipopeptide:• Boosts skin’s natural production of collagen

Step 2: Activate


Offects® TE-PadsAcne Pore Treatment

Enhance the penetration of active ingredients.Control oiliness, breakouts and removes dead cells with:

2% Salicylic Acid• Exfoliates pore-clogging skin cells• Reduces oiliness to help prevent breakouts

Botanical Extracts• Calm and soothe skin

Offects® Exfoliating Polish Enhances the penetration of active ingredients. Remove dead skin cells and sebum with:

Round Magnesium Crystals• Slough off dry skin• Improve skin texture (smoothness)• Restores glow• At-home benefits of microdermabrasion activate and repair skin cells

Four Vitamins (A, C, C-esters and E)• Provide a powerful anti-oxidant protection

Step 3: StimulateProduct Name Ingredients & Benefits


Daily DNA repair and anti-oxidant protection with:Enzymes (Ultrasomes and Roxisomes)• Encourage the skin’s DNA repair mechanism to self-correct Powerful anti-oxidants (Vitamin A & E)• Speed recovery from past UV damage• Help prevent future photo damageRetinol and Matrixyl 3000• Reduce appearance of fine lines and wrinkles• Even skin tone and improve hyper pigmentation• Increase dermal thickness and firmnessOmega-6 Ceramide• Lock-in moisture• Reduce inflammation


Collagen booster helps firm and tone with:Lipopeptides, Amino-Acids and Vitamins A, B & C Derivative• Boost collagen production• Increase dermal thickness and elasticityEpidermal Growth Factor• Stimulates cellular function• Reduces fine lines and wrinkles• Well tolerated by sensitive skin typesRetinol• Reduces appearance of fine lines and wrinkles• Evens skin tone and improves hyper pigmentation• Increases dermal thickness and firmness

Step 3: Stimulate


Ossential® Radical Night Repair Plus Restore functionality, skin elasticity and improve uneven pigmentation with: Ultra-high concentration of Retinol: 1%• 10 times the industry average• Encapsulated time-release formula to increase penetration and reduce irritation• Reduces appearance of fine lines and wrinkles• Evens skin tone and improves hyper pigmentation• Increases dermal thickness and firmnessVitamin C:• Boosts skin brightness; improves skin tone and clarity• Provides anti-oxidant protection• Continuously stimulates cells for optimal collagen production and elasticity improvementAntioxidants (Vitamins C & E, Co-Q10)• Neutralizes free radicals to help reverse the signs of aging• A Crithmum Maritinum Marine Extract• Regulates sebum to help control acne and oiliness



Ommerse®

Daily Renewal CremeHydrate,calm and nourish skin with:Hyaluronic Acid, Jojoba Esters and natural Emollients• Nourish skinAdvanced anti-irritant complex with Oat and Canadian Willowherb extracts• Soothes and reduces inflammationRetinol• Reduces appearance of fine lines and wrinkles• Evens skin tone and improves hyper pigmentation• Increases dermal thickness and firmness Advanced Oxysome liposome system• Delivers Vitamins C & E deeper beneath the surface• Boosts skin’s natural production of collagen• Evens skin toneEctoin• Protects skin’s immune system• Protects against photo-aging and the formation of sunburn cells

Ommerse® Overnight RecoveryCreme

Deeply soothe, calm and nourish skin with:Ceramide 2, Soline, Squalane and Shea Butter• Nourish skin• Protect against Trans Epidermal Water LossAdvanced anti-irritant complex with Oat and Canadian Willowherb extracts• Soothes and reduces inflammationUltrasomes (enzymes)• Repairs DNA damage to increase cell survivalRetinol• Reduces appearance of fine lines and wrinkles• Evens skin tone and improves hyper pigmentation• Increases dermal thickness and firmness

Step 5: Protect, Specialty: Eye


Oclipse® Sunscreen + PrimerSPF 30

Protect, smooth and prime skin for even makeup application with:Natural Melanin, Titanium Dioxide (10.2%) and Zinc Oxide (3.7%)• Protect against UVA/UVB sun damage to reduce the visible signs of aging Lipopeptides• Stimulate collagen productionHumectants and Emollients:• Hydrate and moisturize skin

Olluminate® Intense Eye Repair

Repair, brighten and decrease puffiness with:A blend of encapsulated Retinol, Advanced Peptides and Optical Diffusers• Instantly and continuously help to repair fine lines and wrinkles • Increase epidermal thickness, firmness, elasticity and hydration Mica and Titanium Dioxide• Brightens eye area, minimizes dark circles, reduces puffiness, and the appearance of yellow skin toneMDI Complex (Glycosaminoglycans)• Boost skin’s natural collagen productionVitamin E• Protects against free radical damage

Specialty: Hand + Body


Oraser® Body Emulsion Smooth, hydrate and even skin tone with: Lactic Acid (11.5%) and an anti-oxidant rich complex• Remove dead surface cells• Smooth rough, dry patches Glucosamine• Reduces the appearance of dark spots• Evens skin tone Retinol and Matrixyl 3000• Boost cellular turnover • Reduce appearance of fine lines and wrinkles• Even skin tone and improves hyper pigmentation• Increase dermal thickness and firmnessEmollients• Hydrate immediately• Deliver long lasting moisture

Oraser® Microderm Hand Renewal Exfoliate, soften and condition hands with:Shea Butter, Mango Butter and Safflower Oil• Resurface and condition even ultra-dry skinSugar Crystals and Salicylic Acid• Exfoliate dry skin, improve skin texture and leave hands smoothRetinol• Reduces appearance of fine lines and wrinkles• Evens skin tone and improves hyper pigmentation• Increases dermal thickness and firmness Natural emollients• Leave skin soft and moisturized with light after feel

Specialty: HandProduct Name Ingredients & Benefits

Oraser® Daily Hand Repair SPF 20

Protect against UVA/UVB sun damage (avobenzone 3%) and restore younger-looking hands with:Retinol and Matrixyl 3000• Boost cellular turnover • Reduce appearance of fine lines and wrinkles• Even skin tone and improve hyper pigmentation• Increase dermal thickness and firmnessAmino-Acid Complex (Panthenol, Shea Butter and Hyaluronic acid)• Moisturizes and leaves skin soft and smooth Anti-oxidants Vitamins C, E and Coenzyme-Q10• Neutralize damaging free radicals

Oraser® Overnight Hand Recovery

Relieve dryness and fight signs of aging with: Encapsulated Retinol, Vitamins C, E and Coenzyme-10• Improve skin elasticity, firmness and tone• Protect against the damaging effects of free radicals Vitamin C• Brightens skin• Boosts collagen productionNatural Emollients (Avocado Oil, Shea Butter, Meadowfoam Seed Oil and Hyaluronic Filling Spheres)• Moisturize continuously overnight• Prevent Trans-Epidermal Water Loss (TEWL)Bisabolol• Soothes inflammation

Unique & Compelling Brand Proposition

Systems and Programs that produce results

•System approach to correct, stimulate and saturate

•Luxury and performance should not be mutually exclusive

•Unique value proposition

•Worldwide brand recognition and reputation

•Higher concentrations, more actives, stabilized retinol

•Results driven, serious skincare

Linda Nelson Director of [email protected] Office619-438-3554 Mobile

www.zoskinhealth.com

mailto:[email protected]

http://www.zoskinhealth.com/

Date post:	15-May-2015
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