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My Education Path• Undergraduate– Las Positas/Chabot College (2.5 years)–UC Berkeley (2.5 years)
• Working at start-up– Ion Torrent (1 year)
• Graduate School–UC Berkeley and UC San Francisco
combined graduate program (current)
Bioengineer
Engineering Biology
technical problem-solving
study of life and
medicine
BIOENGINEERING
amyris.com
Bioengineering Research at Berkeley
• Bioinstrumentation– imaging: MRI imaging near metal
implants– diagnostic tools: micro/nano scale
protein analysis– bioMEMS: microfabricated devices
• Microfluidics, drug delivery systems
– artificial organs
• Biomaterials and Nanotechnology– biomimetics– surface coating for implants
• Cell and Tissue Engineering– Stem cells– single cell studies to better
understand cellular systems
• Computational Biology– dna and protein data analysis.– producing models of proteins or
biomolecules
• Systems and Synthetic Biology– controlling microbes to produce
desired molecules such as insulin…fuels, plastics..etc. medication..
https://www.youtube.com/watch?v=_i-_1QdY2Zc
Undergraduate Research Experiences
• Sandia National Lab in Livermore– microfluidics: single
cell macrophage studies
– picoliter reaction chambers
• Virginia Tech: Davalos Lab– simulation of devices
for cancer cell separation
• UC Berkeley: Herr Lab– on-chip protein
separation based on isoelectric point
Working at Ion-array of wells-each one holds a bead with thousands of single stranded DNA-nucleotide flows over it, and if one gets incorporated, H+ released, and so by measuring the pH
Why PhD?
• More opportunities– especially in the bioE field…lot of work
going on in research– easier to lead your own project:
Rotations
• Roy Lab– lung project
• Maharbiz Lab–Miniaturized Tesla turbine
• Herr Lab– protein separation
• PICKED ROY LAB: Artificial Kidney
Nephron
• cleans out toxins and excess substances from blood
• filtration based on size driven by blood pressure
• reabsorption of necessary nutrients, solutes and water via active and passive transport
End Stage Renal Disease
• ESRD: complete or near complete loss of kidney function, often due to diabetes and/or hypertension
• Current treatment:– kidney transplant– hemodialysis
• typically done ~3x/week using external diffusion driven dialysis system
– peritoneal dialysis• patient’s own pertoneum
in diffusion driven filtration
ESRD Statistics
• Data from 2010– more than ~170,000
new ESRD patients added
– prevalence: ~0.6 million
– total kidney transplants: 17,778
– total Medicare ESRD expenditure: $33 billion
– total ESRD expenditure: $47.5 billion
Artificial Kidney
• 2 parts: filtration and reabsorption– filtration based on size– reabsorption bioreactor
• use of silicon membrane– why silicon?
• uniformity high selectivity
• robustness• ease of fabrication through
MEMS technology• mass production• high throughput given area
Silicon Membrane
• Pore Size:– long slits• pore length: 4.5 um• pore height: 13 nm
pore• pore width: 40 um