Department of Marine Life Science /Marine Bio Research & Education Center College of Natural Sciences
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Van-Tinh NguyenMarine Bioactive Substances Lab.Department of Marine Life Science
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Cancer
The Death ?11/7/2012
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Questions we will try to answer11/7/2012
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How do you get cancer?
How are cancerous cells
different than normal cells?
What is the cancer?11/7/2012
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scary
Most frequent cancer in the world
http://www.partsofthebody.net/cancer/
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http://www.healthcareatoz.com/
Causes of Cancer
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Stages of tumor development
Tumor clonality
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Development of colon carcinomas11/7/2012
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Properties of cancer cells
Density-dependent inhibition
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Autocrine growth stimulation11/7/2012
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Growth control in a normal cell
Signaling cell
Growth factor
Growth factor binds to receptor
Receptor sets off a signal cascade to
nucleus
Target cell entersS-phase and divides,eventually repairing
woundTarget cell
Nucleus
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1. Cell might produce its own growth factor
Several ways to get faulty growth control in a cancer cell
2. Mutant receptor might turn on even withoutbinding growth factor
3. Signal cascade might occur even without triggerfrom receptor
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Tumor viruses
DNA —> RNA —> protein
ss = single strand; ds = double strand.(+) RNA is the one which can function as mRNA for the synthesis of proteins. (-) RNA cannot function as mRNA. RT = Reverse transcriptase
http://www.nlv.ch/Virologytutorials/Classification.htm
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HBV Replication cycle
Crowther R. The Leeuwenhoek lecture 2006.Microscopy goes cold: frozen viruses reveal their structural secrets. Trans. R. Soc. B 2008;363:2441-2451http://www.ibibiobase.com/projects/hepatitis/hepatitis-aB.htm
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SV40 and Polyomavirus11/7/2012
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Adenovirus11/7/2012
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The life cycle of retrovirus11/7/2012
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Proto-oncogenes11/7/2012
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Retroviral Oncogenes11/7/2012
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Oncogenes in human cancer
Point mutations in ras oncogenes
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Translocation of c-myc and abl
Translocation of c-myc
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Functions of oncogene products
Oncogenes and the ERK signaling pathway
The AP-1 transcription factor
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Functions of oncogene products
Mechanism of Tel/PDGFR oncogene activation
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Functions of oncogene products
Action of the PML/RARα oncogene
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Oncogenes and cell survival
Tumor suppressor genes
Suppression of tumorigenicity by cell fusion
Inheritance of retinoblastoma
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Suppresion of cell survival by PTEN11/7/2012
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Action of p53 in apoptosisInhibition of cell cycle progression by Rb and p16
Molecular approaches to cancer treatment
Prevention and early detection Molecular diagnosis Treatment
http://www.wwu.edu
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Thank you for listening
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