ENDOCRINE AND METABOLIC RESPONSE
TO
TRAUMA
STIMULI
PNS and CNS
RESPONSE
STIMULI
1.BLOOD VOLUME 2.O2 ,CO2 ,H+3.PAIN4.EMOTIONAL(FEAR & STRESS)5.WOUND
RESPONSE
LOCAL RESPONSE SYTEMIC RESPONSE
TISSUE INJ. NUERO-ENDOCRINE
METABOLIC
LOCAL INJ.
Macrophage or Monocytelysozyme,pg,IL-1,IL-2,TNF,Interferon
NutrophilLeukotriene B4,elastase,acid hydrolaselysozyme,PGE2
Mast cellHistamine,protease,heparin,ECF,PGD2leukotrienes C4,TNF
METABOLIC
GLUCOSE
FAT
PROTEIN
FLUID-ELECTROLYTE
