Gastric and Esophageal Cancer in the United States, 2013
Gastric Cancer Incidence: Geographic Differences
Gastric Adenocarcinoma: Heterogeneous Diseases
Gastric Cancer: Death Rates in the United States
Subcardial Gastric Cancer Incidence: Trends Among
Different Age Groups
Gastric Adenocarcinoma: Heterogeneous Diseases
Esophagogastric Adenocarcinomas: Pathologic
Distinctions
Pathogenesis of Esophagogastric Adenocarcinomas
Gastric Cancer: Molecular Subtypes With Distinct Expression
Profiles
Gene Signature Validated in Primary Gastric Cancers: 2
Patient Cohorts
Identifying Relevant Biologic Targets to Guide Therapeutic
Development
Significantly Mutated Genes in Whole-exome Sequencing
Studies
Exome Sequencing in GEJ and Esophageal Adenocarcinoma
Candidate Biologic Pathways in Gastric Cancer
Gastric Cancer: Single-Agent Chemotherapy
Chemotherapy Regimens for Metastatic Esophagogastric
Cancer
HER/ErbB Family in Gastric Cancer
ToGA: Phase 3 Trial of Trastuzumab in First-line
Gastric/GEJ Cancer
ToGA Primary End Point: OS
ToGA Efficacy: OS by Subgroup Analysis
HER2- Expression Frequency by Histologic Subtype
HER/ErbB Targeting in Gastric Cancer
Rilotumumab in First-line Gastric/GEJ Cancer: Phase 2
Trial
Rilotumumab Efficacy in ITT Population
Rilotumumab Efficacy in MET-High Population
Role of VEGF Pathway in Tumor Growth
VEGF Expression Associated With Worse Survival in Gastric
Cancer
AVAGAST: Bevacizumab in First-line Gastric/GEJ Cancer -
Phase 3 Trial
AVAGAST Primary End Point: OS
Role of VEGF Pathway in Tumor Growth
Neovascularization and VEGFR2 Expression from
Barrett’s to Esophageal Adenocarcinoma
Anti-VEGFR2 MAb in a Gastric Cancer Animal Model
REGARD: Ramucirumab Monotherapy in Second-line
Gastric/GEJ Cancer, Phase 3 Trial
REGARD: Efficacy Results
RAINBOW: Ramucirumab in Second-line Gastric/GEJ
Cancer, Phase 3 Trial
Summary and Conclusions
Summary and Conclusions (cont)
Abbreviations (cont)
Abbreviations (cont)
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)