Sections of DiscussionRin- Types of Cells
Brittany- Introduction and Innate Immune
Vanessa- Acquired Immune SystemZoraida- Immunodeficiency,
Autoimmunity, and HypersensitivityMai – Immunological Memory
Sarah- History of ImmunologyAlisha- AIDS/HIV
Shauna- Types of CancersConclusion
T Cells
Helper T Cells bind to an antigen on the pathogen protein and grow and divide
Killer T cells bind to infected cells and kill
B CellsB Cells bind to antigens and then copy.
Mature clones make antibodies (Large Y shaped proteins with two antigen binding sites)
Antibodies and antigens fit like locks and keys
The Innate Immune System
Body parts that are associated and work with the immune system www.canc
ervic.org.
The Innate Immune System is defined as “nonspecific that is its defenses work against a wide variety of potential pathogens”
Innate Immune SystemBarriers of the Innate Immune
System
Skin- 1.sheds as protective blocking defense so pathogens have a harder time to grip and get into the skin. 2. hair all over skin captures pathogens also around follicles there is a release of chemicalsMucous Membranes- in nose, ears, eyes also have hair in membranes to catch pathogens www.transferfact
or-live.com
Stomach- enzymes in stomach destroy pathogens when they are released to digest foodUrine and bile- form of ridding the body of pathogens from the chemicals in there and the exiting of the bodyTears- enzymes to kill bacteria
Innate Immune systemInflammatory Response
The Inflammatory response- is the process of protecting the injured area and fixing it. Releases histamines to make blood flow faster to injured site and have capillaries leak fluid. The fluid isolates the injury from the rest of the body to isolate the infection. Characteristics- swelling, redness(physical), innate immune system cells being sent to the injured site to repair and kill pathogens(internally)
www.biocarta.com
If the defense is not successful- puss will form. Puss is dead bacteria, cells, and tissue.
Definition
Acquired (adaptive or specific) immunity is not
present at birth. Acquired immunity takes time to develop after
initial exposure to a new antigen. As a person's immune system
encounters foreign substances (antigens), the components of
acquired immunity learn the best way to attack each antigen and
begin to develop a memory for that antigen. Acquired immunity
is also called specific immunity because it tailors its attack to a
specific antigen previously encountered. Its hallmarks are its
ability to learn, adapt, and remember. The acquired immune
response is much slower than that of the innate immune system,
usually taking 3 to 5 days to reach its full force.
B Cells & T Cells
There are also two types of acquired
immune cells B cells and T cells. Both
of these cells are made in the bone
marrow, but they each mature in
different organs.
B C
ells
& T
Cells
B C
ells
T C
ells
B cells target pathogens in bodily fluids.
T cells target pathogens that are inside the body’s cells.
Comparison
Innate Immunity Not very specific
responds to molecules that characterize a wide variety of pathogens, including types of carbohydrates, proteins, & nuclei acids
Response is immediate No memory is retained
of past encounters with pathogens
Several hundred different receptors
Acquired Immunity Very specific, responds to
antigens, most often portions of foreign proteins
Response is delayed, reaching a maximum 3 to 5 days after exposure
Memory is retained of past encounters with pathogens-subsequent responses are faster and more aggressive
Huge number of receptors-somewhere on the order of 10 million
EX
AM
PLE
:
Vaccines Vaccines expose the body to antigens of a particular pathogen.
Most vaccines contain dead or very weak strains of the pathogen or use only a part of the pathogen.
The acquired immune system responds to antigens in the vaccine much as it would to the real pathogen by making antibodies & memory cells. The next time the pathogen is encountered the acquired immune system is ready!
References
Delves, Peter J. (2008, September). Acquired Immunity. Retrieved March 18, 2009, from Merck & Co website: http://www.merck.com/mmhe/sec16/ch183/ch183c.html
Hewitt, Lyons, Suchocki, Yeh. Conceptual Integrated Science. 467-469. Pearson
Immunodeficiency
Immunodeficiency (or immune deficiency) is a state in which the immune system’s ability to fight infectious disease is compromised or entirely absent.
Two forms of this disorder:› Primary
immunodeficiency (PID)
› Acquired immunodeficiency (AIDS)
Autoimmunity
A misdirected immune response that occurs when the immune system goes awry and attacks the body itself.
“Self-Immunity” Not contagious
Hypersensitivity
• a state of altered
reactivity in which
the body reacts with
an exaggerated
immune response to
what is perceived as
a foreign substance.
• Type I: Immediate Hypersensitivity
• Type II: Cytotoxic Hypersensitivity
• Type III: Immune Complex Hypersensitivity
• Type IV: Delayed Hypersensitivity
The Royal Experiment on Immunity1721-1722
Edward Jenner receives the credit for the development of the first effective immunization procedure to protect against an infectious disease (1798 - Published)
Smallpox inoculation (involving the (usually) dermal infection of the subject with the wild virus, which most often resulted in a mild, transient illness that thenceforth protected the individual against more severe forms of the disease
Antibodies
Paroxysmal Cold Hemoglobinuria (PKH) The Wassermann Antibody Autoimmunity to Lens Proteins Sympathetic Ophthalmia
Transplantation
Rules already established by 1912› Transplantation into a foreign species› Transplantation into unrelated members of the
same species› Autografts› The first graft in the allergenic recipient› Recipient that has previously rejected a graft
from the same donor › Close “blood relationship” between donor and
recipient
Nobel Prize
Emil Behring Robert Koch Elie Metchnikoff Paul Ehrlich Charles Richet Jules Bordet Karl Landsteiner Max Theiler Daniel Bovet F. Macfarlane Burnet Peter B. Medawar
•Rodney R Porter•Gerald M. Edelman•Rosalyn Yalow•Roger Guillemin•Andrew Schally•Baruj Benacerraf•Jean Dausset•George Snell•Cesar Milstein•Georges F. Kohler•Niels K. Jerne•Susumu Tonegawa
WHAT IS HIV/AIDS
Short for acquired immune deficiency syndrome. An infectious disease of the immune system caused by an human immunodeficiency virus (HIV). AIDS is characterized by a decrease in the number of helper T cells, rendering the subject highly vulnerable to life-threatening conditions (as Pneumocystis carinii pneumonia) and to some that become life threatening (as Kaposi's sarcoma) which causes a severe immunodeficiency that leaves the body susceptible to a variety of potentially fatal infections. The virus is transmitted in infected bodily fluids such as semen and blood, as through sexual intercourse, the use of contaminated hypodermic syringes, and placental transfer between mother and fetus.
HIV/AIDS SYMPTOMS
THESE SYMPTONS MAY APPEAR TO BE LIKE FLU SYMPTOMS IN THE FIRST STAGES OF THE DISEASE. (FEVER, TIREDNESS, AND ENLARGE LYMPH NODES IN THE NECK).
AS YOU PROGRESS IN THE STAGES YPUR BODY BEGANS TO SHUT DOWN AND YOU BECOME WEAKER AND WEAKER.
TREATMENT
THERE IS ACTUALLY NO CURE FOR HIV/AIDS BUT THERE ARE DIFFERENT MEDICATIONS THAT MAY HELP THE IMMUNE SYSTEM AND KEEP THE DISEASE AT A LOW STAGE
THERE IS ALSO THERAPY
KAPOSI’S SARCOMA
a cancer of connective tissue characterized by painless, purplish-red to brown plaque like or pimply lesions on the extremities, trunk, or head, and sometimes involving the lungs, viscera, etc., occurring in a mild form among older men of certain Mediterranean and central African populations and in a more virulent form among persons with AIDS.
KAPOSI SARCOMA TREATMENT
THIS TREATMENT DEPENDS ON WHAT TYPE OF KAPOSI SARCOMA YOU HAVE, THE GENERAL HEALTH OF THE PATIENT, WHETHER OR NOT THE CANCER HAS SPREAD, AND WHETHER OR NOT THE CANCER HAS BEEN DIAGNOSED.
WHAT IS PNEUMOCYSTIS CARINII PNEUMONIA
a pneumonia chiefly affecting immunocompromised individuals that is caused by a microorganism of the genus Pneumocystis (P. carinii ) which shows up in specially stained preparations of fresh infected lung tissue as cysts containing six to eight oval bodies, that attacks especially the interstitial and alveolar tissues of the lungs, and that is characterized especially by a nonproductive cough, shortness of breath, and fever
TREATMENT
THERE AE DIFFERENT MEDICATION THAT CAN BE GINEN BY MOUTH OF THRIUGH THE VEINS THAT CAN KILL THE BACTERIA
REFERENCE
https://health.google.com/health/ref/Pneumocystis+carinii+pneumonia
http://www.avert.org/treatment.htm
http://dictionary.reference.com
Lymphoma
About 1,700 kids younger than 20 years old
No exact causes, but there are risk factors
Symptoms Tests are run to see what areas of the
body are affected by lymphoma
Lymphoma Cont’d
Treatment is determined by staging Four stages of lymphoma: Stage I – IV Treatment=radiation and/or
chemotherapy Short-term and long-term side effects There is a chance of relapse
Patton, D., & Miller, R. E. (2007, June). Lymphoma. Retrieved from http://kidshealth.org/parent/medical/cancer/cancer_lymphoma.html#
Leukemia
About 2,200 American young people Just like lymphoma there is no exact
causes, there are risk factors Symptoms A child may need certain tests to
detect leukemia
Leukemia Cont’d
Treatment depends on features of leukemia Treatment=radiation and/or chemotherapy Same side effects as treatment of
lymphoma Still a chance of relapse Remission rate of up to 90%
Miller, R. E. (2007, June). Leukemia. Retrieved from http://kidshealth.org/parent/medical/cancer/cancer_leukemia.html#