2.2FmocCl,pyridine,7days

HBr,ace7cacid,4hrs.

pyridine,3hrs.

2.2FmocCl

2.2FmocCl,pyridine,DMAP3hrs.

EtOH,Zndust,1hr.

Ac2O,ZnCl2

100OC,4hrs.

Et3N,pyridine,1hr.

HBr,ace7cacid,24hrs.

HBr,ace7cacid,24hrs.

ace7cacid,Zndust

2hrs.4hrs.

HBr,ace7cacid,4hrs.

20% 9.8%<1%

35%24%

67%

exo

endo

9.6%

23%

exo

endo

89%

5.4% >5%82%

methylacrylateNaHSO3,KBrO3,15min.

~43%