Microsoft power point tm overview sept 15

transcript

TJ RobertsonChief Operating OfficerTIME MEDICAL Systems

September 15, 2010

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A brief introductionA brief introduction

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Professor Q.Y. Ma, PhDProfessor Q.Y. Ma, PhD

Founder,Founder,Chairman & CEOChairman & CEO

Professor Q.Y. Ma, PhDProfessor Q.Y. Ma, PhD

Founder,Founder,Chairman & CEOChairman & CEO

Founded on core technologyFounded on core technologydeveloped in the USA atdeveloped in the USA atColumbia University’sColumbia University’s

Translational Research Lab.Translational Research Lab.and later validated & refinedand later validated & refinedat Harvard Medical Schoolat Harvard Medical Schooland Hong Kong Universityand Hong Kong University

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OurOur USAUSA--basedbased Team of Clinical AdvisorsTeam of Clinical Advisors

Professor William Bradley, M.D., PhDChairman of RadiologyUCSD Medical CenterUniversity of California, San Diego

Prof. Bradley has authored more than 160articles and 17 books on Radiology & MRI.

He is one of the world’s foremostauthorities in MRI & Radiology - and hasprovided 3 decades of critical leadershipacross clinical, technical, research andpolicy-making initiatives.

Professor Ferenc Jolesz, M.D.Director of the MRI DivisionBrigham & Women’s HospitalHarvard Medical School

Prof. Jolesz has published over 300articles and book chapters on Surgery,Computer Science, Neurology,Neurosurgery, Radiology and MRI.

He is widely recognized for his pioneeringinnovations in Radiology and MRIResearch.

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Our ChinaOur China--based Partnersbased Partners

Taizhou, Jiangsu May 31, 2010

TIME MEDICAL SYSTEMSproudly hosts Mr. Li Yuan Chao,

Chairman of theOrganization Department of the

Chinese Communist Party& former Secretary General of Jiangsuprovince. He is a strong supporter of

China Medical City

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Our FacilitiesOur Facilities

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R&D FacilityR&D Facility

HongHong KongKong

HK ScienceHK Science ParkPark

HongHong KongKong

HK ScienceHK Science ParkPark

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SingaporeSingapore

Int’l Business ParkInt’l Business Park

SingaporeSingapore

Int’l Business ParkInt’l Business Park

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ShanghaiShanghai

ZhangjiangZhangjiangHiHi--tech Parktech Park

ShanghaiShanghai

ZhangjiangZhangjiangHiHi--tech Parktech Park

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San DiegoSan Diego

UCSD Medical CenterUCSD Medical Center

San DiegoSan Diego

UCSD Medical CenterUCSD Medical Center

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Production FacilityProduction Facility

TaizhouTaizhou

China Medical CityChina Medical City

Production FacilityProduction Facility

TaizhouTaizhou

China Medical CityChina Medical City

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A brief historyA brief history

MRI Innovations

Higher B0 = higher SNR

The trend of using higherfield strengths to improveSNR is coming to an end,driven mainly by the need forcost-containment andregulatory constraintsplaced on clinical MRI < 4T.

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Magnetic Fields (B0)

Higher B0 = higher SNR

The trend of using higherfield strengths to improveSNR is coming to an end,driven mainly by the need forcost-containment andregulatory constraintsplaced on clinical MRI < 4T.

In spite of RF Array Coil improvements,copper RF coils are the dominant sourceof noise in the MR image.

HTS materials are now considered thebest solution for improving SNR.

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Radio Frequency (RF) Coils

In spite of RF Array Coil improvements,copper RF coils are the dominant sourceof noise in the MR image.

HTS materials are now considered thebest solution for improving SNR.

Phantom image comparison:

(a) signal intensity plot and(b) corresponding cropped images

Room temperature copper

Cooled copper

HTS coil

TIME MEDICAL SYSTEMSbrings HTS RF Technology

to the MRI market.

On June 1, 2010 Professor Ma andhis team received Patent approval

for the development of the 1st“INTEGRATED SUPERCONDUCTOR

MR IMAGING SYSTEM”

According to Prof. Ma“This marks the beginning of the

SUPER MRI era!”

TIME MEDICALSYSTEMS High Temperature

Superconductors (HTS)

to the MRI market.

SUPER MRI era!”

to the MRI market.

SUPER MRI era!”

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High TemperatureSuperconductors (HTS)

to the MRI market.

SUPER MRI era!”

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The beginning of a new era:The beginning of a new era:

HTS MRI

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Hybridthe HTS System

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Hybrid MONA

Hybrid MONAthe HTS System

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The HTS breakthroughled to the new era of

low-cost, high-performanceMRI scanners.

Hybrid PICA (whole body) and Hybrid MONA(dedicated orthopedic) MRI scanners are the

first MRI scanners to take advantage ofHTS RF Coil Technology.

Operating in conventional or HTS mode,the Hybrid PICA and Hybrid MONA MRI scanners

enable a full range of clinical applications,with competitive IQ and scan time.

The HTS breakthroughled to the new era of

low-cost, high-performanceMRI scanners.

Hybrid PICA (whole body) and Hybrid MONA(dedicated orthopedic) MRI scanners are the

first MRI scanners to take advantage ofHTS RF Coil Technology.

Operating in conventional or HTS mode,the Hybrid PICA and Hybrid MONA MRI scanners

enable a full range of clinical applications,with competitive IQ and scan time.

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The news of HTS is getting out.And the recognition is coming in.

On June 24, 2010 Professor Ma and histeam accepted the award for

2010 Medical Imaging ProductInnovation of the Year!

The news of HTS is getting out.And the recognition is coming in.

On June 24, 2010 Professor Ma and histeam accepted the award for

2010 Medical Imaging ProductInnovation of the Year!

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A brief summaryA brief summary

MRI Markets,Opportunities

& Trends

MRI Markets,Opportunities

& Trends

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2,000 MRI systems sold annually / USD $5 Billion annual market

16% annual growth rate

22,000 MRI systems installed globally

30 MRI units per 1M population (USA/Japan)

1.5 MRI units per 1M population (China)

< 1 MRI unit per 1M population (Developing markets)

Approximate Customer Realized Price in Developed Markets (in USD) $3M - Ultra High-field (3T) $1.5M - High-field (1.5T) $500K - Low-field (0.35T)

Global MRI Market and TM opportunityGlobal MRI Market and TM opportunity

2008 2009 2010 2011 2012 2013 2014 2015

GlobalMRI forecast in Mio. USD

2,000 MRI systems sold annually / USD $5 Billion annual market

16% annual growth rate

22,000 MRI systems installed globally

30 MRI units per 1M population (USA/Japan)

1.5 MRI units per 1M population (China)

< 1 MRI unit per 1M population (Developing markets)

Approximate Customer Realized Price in Developed Markets (in USD) $3M - Ultra High-field (3T) $1.5M - High-field (1.5T) $500K - Low-field (0.35T)

2008 2009 2010 2011 2012 2013 2014 2015

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Value!

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Performance!

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Innovation!

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Lowest cost of ownershipLowest cost of ownership

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Fixed costs

Equipment Lease

$ / month

Service Contract

$ / month

Revenue per patient

$ / patient

Lowest break-even fixed costs in the MR industry!Based on xyz market figures

Breakeven

< x Patient per day

(y days / week)

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Fixed costs

Equipment Lease

USD $8,800 / month

Service Contract

USD $4,100 / month

Revenue per patient

USD $360

Lowest break-even fixed costs in the MR industry!Based on Hong Kong market figures

Breakeven

< 2 Patient per day

(6 days / week)

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Hardware, Software & Clinical ApplicationsHardware, Software & Clinical Applications

Performance

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MONA / PICA Specs: Brains and Muscle

• 0.2T / 0.35T• Vertical Field, Open• 30 cm / 42cm opening• 5,500 kg / 17,000 kg• Auto Shimming

Magnet• SE, GE, FSE, FLAIR, STIR, IR-FSE,

Single Shot , 2D/3D TOF MRA• Single, multi-slice, radial, 3D volume

PulseSequences

• 25 mT/m / 33 mT/m (Amplitude)• 50 T/m/s / 90T/m/s (Slew Rate)• 0.5 ms / 0.37 ms (Rise Time)

Gradients

• CP: Head, C-Spine, Shoulder, Knee,Extremity, Wrist/Hand, Foot /Ankle –For both MONA & PICA

• CP: Breast, Flex Body (3 sizes) – ForPICA only

• Multi-Array L/S Spine

RF Coils

• FOV: 5cm – 42 cm• TR: 6 ms – 18 sec• TE: 4 ms (minimum)• Slice Thickness: 2D 2mm (min)• Slice Thickness: 3D 0.25m (min)

ImagingParameters

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Easy-to-Operate Graphic User Interface

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Efficient Siting

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Site Planning Support

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A brief look at the proofA brief look at the proof

MRI Images

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HTS Head Coil

HTS Helmholtz Coil HTS Wrist Coil

Quad C-Spine Array CoilQuad Head Array Coil

Quad Body Array Coil

HTS Knee Coil

Quad Wrist Array Coil

Quad Ankle Array CoilQuad Knee Array Coil

Quad Shoulder Array Coil

Large FOV Spine Coil

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Patient Comfort + Fast Scan Times =Patient Comfort + Fast Scan Times =

MRI for All…

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Hybrid MONA and PICA’s Open-design offerspatient comfort and fast acquisition times.

This ensures that scans are successfullycompleted on the most challenging patients.

Especially important for children, elderly &sedated patients, as well as those sufferingfrom claustrophobia.

Hybrid MONA and PICA’s Open-design offerspatient comfort and fast acquisition times.

This ensures that scans are successfullycompleted on the most challenging patients.

Especially important for children, elderly &sedated patients, as well as those sufferingfrom claustrophobia.

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Patient Comfort

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Fast Acquisition TimesThe 20 minute BRAIN MRI Scan

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NonNon--obsolescence through HTSobsolescence through HTS

Innovation

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Copper RF coilsremain the dominant source of noise

in MR image.

HTS RF Coilsovercome this problem!

Copper RF coilsremain the dominant source of noise

in MR image.

HTS RF Coilsovercome this problem!

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Phantom image comparison:

(a) signal intensity plot and(b) corresponding cropped images

Room temperature copper

Cooled copper

HTS coil

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A brief comparisonA brief comparison

HTS Results

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HTS vs. CopperHTS Coil Technology

Copper Coil

SNR = 57

HTS Coil

SNR = 192

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HTS Coil TechnologyHTS vs. Copper

Copper Coil

SNR = 25

HTS Coil

SNR = 51

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HTS vs. Cu RF Coil at 2THTS Coil Technology

HTS coil Cu surface coil Cu volume coil

2T Rat Brain in-vivo images using HTS surface coil.

The SNR ratio for is 8:4:1 respectively

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1. LN / out Tubes

2. Vacuum Port

High Resolution InHigh Resolution In--Vivo MR MicroscopyVivo MR Microscopy

3. DC connector

4. Seal Screws

Rat brain images obtained in vivo with an HTS coil at 2.0T

25 µm resolution

Images courtesy of the NIH Center for In vivo Microscopy at Duke University

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HTS White Paper

The Hybrid MRI systemscan be run

in the traditional,or HTS mode…

The Hybrid MRI systemscan be run

in the traditional,or HTS mode…

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HTS Poster fromISMRM 2010

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HTS:Peer Review

Journal Articles

HTS:Peer Review

Journal Articles

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Hybrid MONA & Hybrid PICAbring a new dimension to MR Imaging.

HTS Technologymake high performance MRI available to all.

TIME MEDICAL SYSTEMSVision Beyond Imagination.

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863 mm slice thickness

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873 mm slice thickness

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Thank You.

This information is furnished without warranty, representation, or license of any kind, except that it is accurate to the best of Time Medical’s knowledge or obtained from sources believed to be accurate. TimeMedical does not assume any legal responsibility for use or reliance upon same. Customers are encouraged to conduct their own evaluation. Before using any product, read the product manuals and labels. Forproducts/features under development the information is provided to assist you. Until Time Medical releases this product for general sale, Time Medical reserves the right to alter prices, specifications, features,capabilities, function, manufacturing release dates, and even general availability of the product at any time.

Microsoft power point tm overview sept 15

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