2014 Chem/Endo/Tx1

Ethanol, serum N Mean SD AM-1 N Mean SD AM-2 N Mean SD AM-3 N Mean SD AM-4 N Mean SD AM-5SG: Beckman Coulter Instruments 36 72 3.00 54-90 37 72 3.50 54-90 37 30 1.80 23-38 36 216 7.90 162-270 35 152 4.50 114-190 PG: Beckman Coulter UniCel DxC 600

Synchron series 21 72 2.70 54-90 21 71 2.90 53-89 21 30 1.70 23-38 21 215 7.80 161-269 21 152 4.40 114-190 PG: Beckman Coulter UniCel DxC 800

Synchron series 11 73 4.00 55-91 11 73 3.80 55-91 11 30 2.10 23-38 11 218 8.10 164-273 11 155 7.40 116-194 PG: Siemens Dimension Vista 13 72 3.70 54-90 13 72 2.20 54-90 13 31 2.10 23-39 13 221 9.50 166-276 13 152 6.00 114-190 PG: Ortho Diagnostics VITROS 350 13 63 1.60 47-79 13 63 1.40 47-79 13 28 0.90 21-35 13 192 7.40 144-240 13 132 3.50 99-165

PG: Ortho Diagnostics VITROS 5600 13 63 3.00 47-79 13 63 2.50 47-79 13 26 1.20 20-33 13 188 9.80 141-235 13 129 6.40 97-161 PG: Roche cobas c 501 15 70 2.50 53-88 16 70 3.00 53-88 16 28 1.50 21-35 16 213 6.20 160-266 16 149 3.50 112-186 PG: Siemens Dimension EXL 36 72 2.70 54-90 37 72 2.70 54-90 37 31 1.70 23-39 37 218 6.90 164-273 36 152 5.40 114-190 PG: Siemens Dimension RxL 12 72 3.70 54-90 12 72 3.00 54-90 12 30 1.70 23-38 12 217 4.70 163-271 12 152 3.70 114-190 SG: Roche Cobas Instruments 25 70 2.20 53-88 26 70 2.60 53-88 26 28 1.40 21-35 26 212 5.70 159-265 26 148 3.20 111-185

SG: Siemens Dimension Instruments 67 72 2.70 54-90 68 72 2.40 54-90 69 30 1.70 23-38 69 218 7.10 164-273 68 152 4.90 114-190 SG: Ortho VITROS Instruments 32 63 2.50 47-79 30 64 1.30 48-80 32 27 1.20 20-34 32 190 9.20 143-238 32 131 5.40 98-164 AG: All Group 193 70 4.40 53-88 196 70 4.30 53-88 194 29 2.00 22-36 195 212 13.50 159-265 195 148 9.60 111-185 Cholesterol, total (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5

PG: Siemens ADVIA 1800 / Genzyme 1 198 0.00 178-218 1 126 0.00 113-139 1 164 0.00 148-180 1 263 0.00 237-289 1 205 0.00 185-226 SG: Beckman Coulter Instruments 18 179 3.50 161-197 18 111 2.30 100-122 19 149 4.30 134-164 19 238 6.60 214-262 19 186 5.80 167-205 PG: Siemens Dimension Xpand 21 171 4.20 154-188 20 110 2.40 99-121 20 141 2.90 127-155 21 225 5.50 203-248 21 174 4.00 157-191 PG: Ortho Diagnostics VITROS 350 21 180 4.10 162-198 21 104 3.00 94-114 21 143 3.60 129-157 21 239 5.10 215-263 21 188 4.80 169-207 PG: Roche cobas c 501 10 186 6.80 167-205 10 116 5.30 104-128 10 152 5.50 137-167 10 245 7.10 221-270 10 192 10.00 173-211 PG: Roche COBAS Integra 12 178 3.20 160-196 12 112 2.40 101-123 12 147 3.40 132-162 12 233 5.30 210-256 12 182 4.30 164-200 PG: Siemens Dimension EXL 34 171 3.40 154-188 34 110 2.60 99-121 34 143 3.00 129-157 34 227 4.60 204-250 34 174 3.40 157-191 SG: Roche Cobas Instruments 28 181 5.20 163-199 29 114 4.60 103-125 29 149 5.20 134-164 29 238 8.60 214-262 28 186 6.70 167-205

SG: Siemens Dimension Instruments 62 171 4.00 154-188 62 110 3.20 99-121 62 142 3.80 128-156 62 226 5.10 203-249 62 174 3.90 157-191 SG: Ortho VITROS Instruments 42 180 4.40 162-198 41 104 3.20 94-114 42 143 3.90 129-157 42 242 7.80 218-266 42 188 4.90 169-207 SG: Beckman Coulter UniCel DxC

Instruments 10 180 3.70 162-198 10 112 2.50 101-123 10 150 2.20 135-165 10 240 7.30 216-264 10 190 5.40 171-209 SG: Architect c Instruments 10 186 2.10 167-205 10 118 1.50 106-130 10 154 1.40 139-169 10 247 2.80 222-272 10 190 2.30 171-209 AG: All Group 177 177 6.90 159-195 175 110 5.20 99-121 177 145 5.60 131-160 176 235 10.10 212-259 176 183 8.40 165-201 CO2, total (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 10 26 1.40 21-31 10 31 1.20 26-36 10 24 1.60 19-29 10 42 3.00 37-47 10 15 2.20 10-20SG: Beckman Coulter Instruments 24 25 1.60 20-30 24 30 1.70 25-35 24 23 1.40 18-28 24 40 2.40 35-45 24 15 1.70 10-20PG: Siemens Dimension Xpand 45 26 1.20 21-31 44 31 1.10 26-36 44 24 1.10 19-29 44 41 2.00 36-46 45 16 1.40 11-21

PG: Ortho Diagnostics VITROS 250/400/500 11 23 0.90 18-28 11 26 1.00 21-31 11 20 1.00 15-25 11 36 1.30 31-41 11 13 1.40 8-18PG: Ortho Diagnostics VITROS 350 32 24 1.40 19-29 32 26 1.40 21-31 32 21 1.40 16-26 32 37 1.70 32-42 32 14 1.40 9-19PG: Roche cobas c 501 12 23 1.80 18-28 12 29 2.00 24-34 12 21 1.30 16-26 12 38 2.40 33-43 12 13 0.90 8-18PG: Roche COBAS Integra 12 23 1.30 18-28 12 28 1.40 23-33 12 20 1.40 15-25 12 37 2.00 32-42 12 13 1.60 8-18PG: Siemens Dimension EXL 36 27 1.30 22-32 36 32 1.30 27-37 36 25 2.20 20-30 36 42 2.00 37-47 36 16 1.40 11-21SG: Roche Cobas Instruments 30 23 1.50 18-28 32 29 2.00 24-34 32 21 1.80 16-26 32 38 2.50 33-43 30 13 1.30 8-18

SG: Siemens Dimension Instruments 90 26 1.30 21-31 89 32 1.20 27-37 88 24 1.30 19-29 89 41 2.10 36-46 90 16 1.40 11-21SG: Ortho VITROS Instruments 55 23 1.30 18-28 55 26 1.20 21-31 55 21 1.20 16-26 55 37 1.80 32-42 55 14 1.50 9-19SG: Beckman Coulter UniCel DxC

Instruments 14 24 1.70 19-29 14 29 1.60 24-34 14 23 1.20 18-28 14 40 1.40 35-45 14 15 1.30 10-20

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

SG: Architect c Instruments 10 21 2.00 16-26 10 27 2.10 22-32 10 20 1.80 15-25 10 37 2.40 32-42 10 13 1.00 8-18AG: All Group 221 25 2.10 20-30 224 29 2.70 24-34 223 22 2.20 17-27 224 39 3.00 34-44 222 15 1.90 10-20Cortisol N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 AG: All Group 15 17.9 1.72 13.4-22.4 15 4.8 0.63 3.6-6.0 15 9.8 1.12 7.4-12.3 15 36.6 2.99 27.5-45.8 15 14.5 1.25 10.9-18.1 Creatine kinase, total N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 7 153 14.90 107-199 7 23 2.30 16-30 7 81 7.50 57-105 7 331 15.80 232-430 7 133 17.80 93-173 SG: Beckman Coulter Instruments 16 175 21.80 123-228 16 29 5.70 20-38 16 94 13.00 66-122 16 365 33.60 256-475 16 153 21.80 107-199 PG: Ortho Diagnostics VITROS 350 20 143 9.30 100-186 20 21 2.40 15-27 20 79 4.00 55-103 20 248 15.80 174-322 20 142 9.90 99-185 PG: Roche cobas c 501 10 187 20.00 131-243 10 28 3.20 20-36 10 101 5.70 71-131 10 402 7.50 281-523 10 170 15.40 119-221 PG: Siemens Dimension EXL / Dimension

Revised CKI reagent 20 171 4.10 120-222 20 25 2.00 18-33 20 91 2.60 64-118 20 353 8.20 247-459 20 150 5.60 105-195 SG: Roche Cobas Instruments 21 194 8.10 136-252 21 30 2.40 21-39 21 104 3.20 73-135 22 400 7.90 280-520 21 173 7.90 121-225

SG: Siemens Dimension Instruments 17 168 14.00 118-218 17 24 2.70 17-31 16 89 4.20 62-116 17 353 12.60 247-459 17 148 14.40 104-192

SG: Siemens Dimension Instruments /

Dimension RevisedCKI reagent 31 171 3.70 120-222 31 25 2.20 18-33 31 91 2.50 64-118 31 354 7.20 248-460 31 151 5.10 106-196 SG: Ortho VITROS Instruments 35 144 9.30 101-187 35 21 3.70 15-27 35 80 4.80 56-104 34 248 11.60 174-322 35 142 9.70 99-185 SG: Architect c Instruments 10 182 14.40 127-237 10 28 3.00 20-36 10 96 7.80 67-125 10 386 10.20 270-502 10 162 14.50 113-211 AG: All Group 135 167 24.70 117-217 135 25 5.20 18-33 135 90 12.50 63-117 136 334 64.50 234-434 135 152 19.90 106-198 Creatinine (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 10 3.12 0.08 2.65-3.59 10 0.46 0.08 0.16-0.76 10 2.91 0.07 2.47-3.35 10 1.36 0.07 1.06-1.66 10 5.35 0.10 4.55-6.15 SG: Beckman Coulter Instruments 21 3.07 0.09 2.61-3.53 21 0.44 0.06 0.14-0.74 21 2.87 0.08 2.44-3.30 21 1.31 0.09 1.01-1.61 21 5.34 0.12 4.54-6.14 PG: Siemens Dimension Xpand 45 3.17 0.10 2.69-3.65 45 0.49 0.07 0.19-0.79 45 2.98 0.09 2.53-3.43 44 1.36 0.09 1.06-1.66 44 5.44 0.10 4.62-6.26

PG: Ortho Diagnostics VITROS 250/400/500 12 3.07 0.10 2.61-3.53 12 0.45 0.04 0.15-0.75 12 2.98 0.08 2.53-3.43 12 0.92 0.03 0.62-1.22 12 5.78 0.16 4.91-6.65 PG: Ortho Diagnostics VITROS 350 32 3.08 0.10 2.62-3.54 32 0.46 0.05 0.16-0.76 32 2.99 0.10 2.54-3.44 32 0.91 0.05 0.61-1.21 32 5.79 0.18 4.92-6.66 PG: Siemens Dimension EXL 36 3.12 0.12 2.65-3.59 36 0.44 0.12 0.14-0.74 36 2.95 0.12 2.51-3.39 36 1.3 0.11 1.00-1.60 36 5.36 0.12 4.56-6.16 SG: Roche Cobas Instruments 14 2.93 0.16 2.49-3.37 14 0.41 0.04 0.11-0.71 14 2.75 0.11 2.34-3.16 14 1.22 0.12 0.92-1.52 14 5.01 0.21 4.26-5.76

SG: Roche Cobas Instruments / Roche

Enzymatic Creatinine reagent 4 3.25 0.12 2.76-3.74 4 0.52 0.02 0.22-0.82 4 3.05 0.06 2.59-3.51 4 1.41 0.09 1.11-1.71 4 5.52 0.16 4.69-6.35 SG: Roche Cobas Instruments / Roche Jaffe

Creatinine reagent 15 2.89 0.16 2.46-3.32 15 0.4 0.04 0.10-0.70 15 2.7 0.13 2.29-3.11 15 1.2 0.15 0.90-1.50 15 4.96 0.30 4.22-5.70

SG: Siemens Dimension Instruments 87 3.15 0.10 2.68-3.62 88 0.47 0.10 0.17-0.77 88 2.97 0.11 2.52-3.42 86 1.33 0.09 1.03-1.63 86 5.41 0.10 4.60-6.22 SG: Ortho VITROS Instruments 58 3.09 0.11 2.63-3.55 59 0.46 0.05 0.16-0.76 58 2.99 0.09 2.54-3.44 58 0.92 0.05 0.62-1.22 58 5.8 0.19 4.93-6.67 SG: Beckman Coulter UniCel DxC

Instruments 11 3.03 0.09 2.58-3.48 11 0.42 0.03 0.12-0.72 11 2.83 0.07 2.41-3.25 11 1.25 0.06 0.95-1.55 11 5.32 0.14 4.52-6.12 SG: Architect c Instruments 10 3.31 0.08 2.81-3.81 10 0.52 0.03 0.22-0.82 10 3.04 0.08 2.58-3.50 10 1.51 0.05 1.21-1.81 10 5.64 0.12 4.79-6.49 AG: All Group 223 3.09 0.16 2.63-3.55 225 0.46 0.08 0.16-0.76 224 2.92 0.15 2.48-3.36 224 1.21 0.21 0.91-1.51 221 5.42 0.34 4.61-6.23 Digoxin N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 15 1.4 0.21 1.1-1.7 15 0.3 0.11 0.1-0.5 15 0.7 0.22 0.5-0.9 15 3.1 0.30 2.5-3.7 15 1.3 0.18 1.0-1.6 PG: Ortho Diagnostics VITROS 350 11 1.3 0.13 1.0-1.6 11 0.4 0.05 0.2-0.6 11 0.7 0.08 0.5-0.9 11 2.7 0.15 2.2-3.2 11 1.2 0.09 1.0-1.4 PG: Siemens Dimension EXL 25 1.6 0.07 1.3-1.9 25 0.2 0.08 0.0-0.4 25 0.8 0.07 0.6-1.0 24 3.2 0.11 2.6-3.8 25 1.4 0.07 1.1-1.7 SG: Roche Cobas Instruments 12 1.6 0.30 1.3-1.9 12 0.3 0.05 0.1-0.5 12 0.8 0.10 0.6-1.0 12 3.3 0.54 2.6-4.0 12 1.4 0.21 1.1-1.7

SG: Siemens Dimension Instruments 36 1.6 0.08 1.3-1.9 36 0.2 0.07 0.0-0.4 36 0.8 0.07 0.6-1.0 35 3.2 0.15 2.6-3.8 36 1.4 0.07 1.1-1.7 SG: Ortho VITROS Instruments 21 1.4 0.15 1.1-1.7 20 0.4 0.11 0.2-0.6 20 0.7 0.07 0.5-0.9 20 2.6 0.27 2.1-3.1 21 1.2 0.12 1.0-1.4 AG: All Group 94 1.5 0.16 1.2-1.8 94 0.3 0.10 0.1-0.5 92 0.8 0.11 0.6-1.0 91 3.1 0.33 2.5-3.7 95 1.4 0.15 1.1-1.7 Albumin (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments /

Bromcresol purple (BCP) 12 2.5 0.26 2.3-2.8 11 1.3 0.11 1.2-1.4 11 1.8 0.19 1.6-2.0 11 3.8 0.42 3.4-4.2 11 2.4 0.26 2.2-2.6 PG: Siemens Dimension Xpand /

Bromcresol purple (BCP) 37 2.3 0.07 2.1-2.5 36 1.1 0.05 1.0-1.2 36 1.7 0.04 1.5-1.9 36 3.6 0.08 3.2-4.0 36 2.3 0.06 2.1-2.5

PG: Ortho Diagnostics VITROS 250/400/500

/ Bromcresolgreen (BCG) 10 3.1 0.08 2.8-3.4 10 1.6 0.05 1.4-1.8 10 2.2 0.05 2.0-2.4 10 4.7 0.15 4.2-5.2 10 3.1 0.11 2.8-3.4

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

PG: Ortho Diagnostics VITROS 350 /

Bromcresol green(BCG) 24 3.1 0.10 2.8-3.4 24 1.5 0.06 1.4-1.6 24 2.2 0.07 2.0-2.4 24 4.7 0.17 4.2-5.2 24 3.1 0.09 2.8-3.4 PG: Siemens Dimension EXL / Bromcresol

purple (BCP) 32 2.3 0.05 2.1-2.5 32 1.1 0.04 1.0-1.2 32 1.7 0.04 1.5-1.9 32 3.6 0.06 3.2-4.0 32 2.3 0.05 2.1-2.5 SG: Roche Cobas Instruments / Bromcresol

green (BCG) 22 3.3 0.11 3.0-3.6 22 1.7 0.09 1.5-1.9 22 2.5 0.11 2.3-2.8 22 4.9 0.12 4.4-5.4 22 3.2 0.13 2.9-3.5

SG: Siemens Dimension Instruments /

Bromcresol purple(BCP) 75 2.3 0.06 2.1-2.5 75 1.1 0.05 1.0-1.2 75 1.7 0.04 1.5-1.9 75 3.6 0.08 3.2-4.0 75 2.3 0.06 2.1-2.5 SG: Ortho VITROS Instruments / Bromcresol

green (BCG) 43 3.1 0.09 2.8-3.4 43 1.5 0.05 1.4-1.6 43 2.2 0.06 2.0-2.4 42 4.7 0.17 4.2-5.2 43 3.1 0.09 2.8-3.4

SG: Beckman Coulter UniCel DxC

Instruments / Bromcresolpurple (BCP) 10 2.4 0.05 2.2-2.6 10 1.3 0.05 1.2-1.4 10 1.8 0.03 1.6-2.0 10 3.7 0.12 3.3-4.1 10 2.4 0.07 2.2-2.6 SG: Architect c Instruments / Bromcresol

purple (BCP) 5 2.2 0.05 2.0-2.4 5 1.1 0.04 1.0-1.2 5 1.6 0.04 1.4-1.8 5 3.3 0.04 3.0-3.6 5 2.1 0.05 1.9-2.3 MG: Bromcresol green (BCG) 90 3.2 0.16 2.9-3.5 90 1.6 0.10 1.4-1.8 90 2.3 0.14 2.1-2.5 88 4.8 0.19 4.3-5.3 89 3.2 0.13 2.9-3.5 MG: Bromcresol purple (BCP) 90 2.3 0.08 2.1-2.5 91 1.1 0.07 1.0-1.2 90 1.7 0.06 1.5-1.9 91 3.6 0.13 3.2-4.0 90 2.3 0.08 2.1-2.5 AG: All Group 215 2.8 0.44 2.5-3.1 215 1.4 0.25 1.3-1.5 215 2 0.34 1.8-2.2 215 4.2 0.61 3.8-4.6 214 2.8 1.46 2.5-3.1 FT3 N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 AG: All Group 21 5.91 3.81 0.00-17.33 21 3.12 1.96 0.00-8.99 21 3.8 2.60 0.00-11.61 21 10.12 5.36 0.00-26.19 21 4.41 3.14 0.00-13.84 FT4 N Mean SD CET-2 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Siemens Dimension EXL 22 3.34 0.13 2.96-3.71 22 1.34 0.05 1.19-1.49 22 2.08 0.08 1.84-2.32 22 6.05 0.21 5.41-6.69 22 2.74 0.09 2.48-3.00 SG: Roche Cobas Instruments 15 3.11 0.14 2.69-3.53 15 1.42 0.06 1.24-1.60 15 2.11 0.09 1.84-2.38 15 5.42 0.24 4.69-6.15 15 2.7 0.11 2.39-3.02

SG: Siemens Dimension Instruments 31 3.35 0.14 2.94-3.76 32 1.33 0.10 1.03-1.63 32 2.12 0.17 1.61-2.63 33 5.72 0.56 4.03-7.41 31 2.78 0.13 2.38-3.18 SG: Ortho VITROS Instruments 10 6.95 0.09 6.67-7.23 10 3.87 0.23 3.17-4.57 10 5.36 0.43 4.08-6.64 10 6.99 0.00 >6.99 10 6.38 0.29 5.51-7.25 AG: All Group 93 3.58 1.32 0.00-7.55 91 1.57 0.72 0.00-3.74 92 2.38 1.01 0.00-5.42 95 5.44 1.06 2.28-8.61 93 3.09 1.27 0.00-6.90 Gentamicin N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Siemens Dimension EXL 16 3.7 0.09 2.8-4.6 16 9.8 0.26 7.4-12.3 16 5.6 0.17 4.2-7.0 16 2.6 0.14 2.0-3.3 16 1.2 0.14 0.9-1.5

SG: Siemens Dimension Instruments 21 3.7 0.10 2.8-4.6 21 9.8 0.27 7.4-12.3 21 5.6 0.16 4.2-7.0 21 2.5 0.13 1.9-3.1 21 1.2 0.13 0.9-1.5 AG: All Group 41 3.8 0.22 2.8-4.8 42 10 0.68 7.5-12.5 42 5.8 0.40 4.3-7.3 42 2.6 0.22 2.0-3.3 40 1.2 0.15 0.9-1.5

GGT (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 12 104 17.70 83-125 12 22 4.10 18-26 12 86 14.30 69-103 12 87 13.20 70-104 12 151 25.40 121-181 PG: Siemens Dimension EXL 16 132 2.70 106-158 16 32 1.70 26-38 16 111 3.00 89-133 16 115 2.50 92-138 16 189 4.00 151-227 SG: Roche Cobas Instruments 13 97 2.10 78-116 13 19 1.00 15-23 13 81 1.80 65-97 13 81 2.30 65-97 13 144 5.60 115-173

SG: Siemens Dimension Instruments 29 132 2.60 106-158 29 31 1.60 25-37 29 111 3.00 89-133 29 115 2.70 92-138 29 191 4.80 153-229 SG: Ortho VITROS Instruments 17 156 3.40 125-187 16 34 1.40 27-41 17 133 3.00 106-160 17 132 3.90 106-158 17 219 4.50 175-263 AG: All Group 80 124 23.40 99-149 79 27 6.20 22-32 80 104 20.60 83-125 80 106 20.40 85-127 79 179 31.00 143-215 Glucose (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 10 156 14.30 140-172 10 96 1.60 86-106 10 166 9.40 149-183 10 43 1.00 37-49 10 236 18.10 212-260 PG: Siemens Dimension Xpand 45 158 2.30 142-174 45 96 1.50 86-106 45 169 2.30 152-186 44 50 1.20 44-56 45 241 4.30 217-265 PG: Ortho Diagnostics VITROS 350 34 152 3.40 137-167 34 91 2.60 82-100 34 161 3.50 145-177 33 45 2.00 39-51 33 235 3.60 212-259 PG: Roche cobas c 501 12 156 3.10 140-172 12 96 1.70 86-106 12 168 2.20 151-185 12 44 0.50 38-50 12 243 8.00 219-267 PG: Roche COBAS Integra 12 155 3.10 140-171 12 95 1.50 86-105 12 167 2.90 150-184 12 43 1.70 37-49 12 239 4.70 215-263 PG: Siemens Dimension EXL 35 158 2.20 142-174 35 96 1.70 86-106 36 169 2.80 152-186 36 50 1.50 44-56 36 242 3.90 218-266 SG: Roche Cobas Instruments 32 155 3.20 140-171 32 95 1.90 86-105 32 167 3.10 150-184 32 43 1.20 37-49 31 240 5.30 216-264

SG: Siemens Dimension Instruments 87 158 2.20 142-174 86 96 1.50 86-106 87 169 2.50 152-186 86 50 1.20 44-56 88 241 4.00 217-265 SG: Ortho VITROS Instruments 59 152 3.50 137-167 59 91 2.40 82-100 58 161 3.00 145-177 58 44 1.90 38-50 58 235 4.10 212-259 SG: Beckman Coulter UniCel DxC

Instruments 11 153 3.50 138-168 11 94 3.30 85-103 11 168 3.60 151-185 11 44 3.40 38-50 11 240 6.80 216-264 SG: Architect c Instruments 10 152 1.60 137-167 10 94 1.30 85-103 10 166 2.40 149-183 10 43 0.50 37-49 10 238 3.10 214-262 AG: All Group 224 155 4.40 140-171 224 94 3.10 85-103 224 166 4.90 149-183 225 47 3.60 41-53 223 239 6.60 215-263 ALP (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

PG: Siemens ADVIA 1800 / Genzyme 1 262 0.00 183-341 1 24 0.00 17-31 1 233 0.00 163-303 1 143 0.00 100-186 1 446 0.00 312-580 PG: Beckman Coulter AU series 10 172 14.50 120-224 10 16 1.40 11-21 10 151 12.30 106-196 10 95 8.20 67-124 10 290 24.60 203-377 SG: Beckman Coulter Instruments 21 176 11.10 123-229 21 17 1.50 12-22 21 155 9.90 109-202 21 97 6.90 68-126 21 293 20.20 205-381 PG: Siemens Dimension Xpand 44 209 9.60 146-272 44 26 4.20 18-34 44 186 7.50 130-242 43 116 5.40 81-151 45 348 21.90 244-452

PG: Ortho Diagnostics VITROS 250/400/500 11 130 5.90 91-169 11 21 2.90 15-27 11 108 32.00 76-140 11 86 3.80 60-112 11 188 12.80 132-244 PG: Ortho Diagnostics VITROS 350 30 131 6.40 92-170 29 20 1.60 14-26 29 119 6.00 83-155 30 84 4.20 59-109 30 194 11.90 136-252 PG: Roche cobas c 501 12 190 5.90 133-247 12 18 0.50 13-23 12 166 6.10 116-216 12 102 2.40 71-133 12 313 13.90 219-407 PG: Roche COBAS Integra 12 187 6.60 131-243 12 17 1.10 12-22 12 166 5.10 116-216 12 100 2.70 70-130 12 310 15.20 217-403 PG: Siemens Dimension EXL 35 224 8.60 157-291 35 34 6.50 24-44 35 201 8.60 141-261 36 128 7.80 90-166 36 366 21.10 256-476 SG: Roche Cobas Instruments 32 188 6.30 132-244 32 17 1.10 12-22 32 166 5.80 116-216 32 101 2.80 71-131 32 313 13.90 219-407

SG: Siemens Dimension Instruments 86 216 11.60 151-281 86 29 6.30 20-38 86 193 10.70 135-251 85 121 8.00 85-157 88 356 23.10 249-463 SG: Ortho VITROS Instruments 52 132 6.70 92-172 50 20 1.70 14-26 50 119 6.10 83-155 52 86 4.90 60-112 52 193 12.10 135-251 SG: Beckman Coulter UniCel DxC

Instruments 11 180 5.20 126-234 11 17 1.50 12-22 11 158 5.60 111-205 11 99 4.90 69-129 11 297 15.70 208-386 SG: Architect c Instruments 10 211 7.60 148-274 10 20 0.90 14-26 10 187 7.00 131-243 10 115 3.20 81-150 10 348 13.50 244-452 AG: All Group 215 187 35.90 131-243 211 23 6.60 16-30 213 166 30.80 116-216 214 106 16.10 74-138 216 303 68.80 212-394 hCG, serum (quantitative) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 10 464 75.54 237.4-690.6 10 30.5 14.96 0.0-75.4 9 446.4 49.73 297.2-595.6 9 295 29.07 207.8-382.2 9 673.5 69.52 464.9-882.1

PG: Siemens IMMULITE 1000 3 1798 155.91 1330.3-2265.7 3 40.2 4.26 27.4-53.0 3 1654.7 148.67 1208.7-2100.7 3 957.7 81.64 712.8-1202.6 3 2990.3 250.77 2238.0-3742.6

PG: Roche cobas e 411 13 1006.6 68.38 801.5-1211.7 14 22.2 1.79 16.8-27.6 13 895.6 67.27 693.8-1097.4 13 518.3 37.32 406.3-630.3 13 1763.1 131.23 1369.4-2156.8

PG: Siemens Dimension EXL 27 1810.5 153.58 1349.8-2271.2 27 19.5 1.46 15.1-23.9 26 1555.4 113.39 1215.2-1895.6 27 782.6 40.38 661.5-903.7 27 3110.5 326.46 2131.1-4089.9

PG: Siemens IMMULITE 2000 1 1850 0.00 1850.0-1850.0 1 49.7 0.00 49.7-49.7 1 1603 0.00 1603.0-1603.0 1 965 0.00 965.0-965.0 1 2834 0.00 2834.0-2834.0

PG: Siemens IMMULITE 2000 / Other reagent 2 1618 70.71 1405.9-1830.1 2 48.6 0.28 47.8-49.4 2 1586 108.89 1259.3-1912.7 2 960.5 37.48 848.1-1072.9 2 2544 171.12 2030.6-3057.4

SG: Roche Cobas Instruments 16 1013.4 63.04 824.3-1202.5 18 22.3 1.73 17.1-27.5 16 897.9 60.86 715.3-1080.5 16 520.2 33.86 418.6-621.8 16 1766.9 117.84 1413.4-2120.4

SG: Siemens Dimension Instruments 37 1787.2 166.36 1288.1-2286.3 36 19.2 1.41 15.0-23.4 36 1560.4 115.07 1215.2-1905.6 37 783.9 41.75 658.6-909.1 37 3090.7 313.92 2148.9-4032.5

SG: Ortho VITROS Instruments 11 1661.6 344.61 627.8-2695.4 11 26.4 2.53 18.8-34.0 11 1531 340.58 509.3-2552.7 11 805.5 156.47 336.1-1274.9 11 2949.8 624.58 1076.1-4823.5

AG: All Group 94 1430 534.40 0.0-3033.2 94 23.6 6.31 4.7-42.5 93 1266.6 458.99 0.0-2643.6 94 679.8 219.17 22.3-1337.3 93 2434.4 976.83 0.0-5364.9

Iron, total N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 13 161 8.20 129-193 12 60 3.80 48-72 13 116 5.60 93-139 13 240 12.80 192-288 13 172 8.40 138-206 PG: Siemens Dimension EXL 19 150 2.80 120-180 19 59 2.60 47-71 19 108 2.70 86-130 19 226 3.90 181-271 19 159 3.40 127-191 SG: Roche Cobas Instruments 10 156 2.70 125-187 10 60 1.40 48-72 10 113 2.00 90-136 10 234 5.70 187-281 10 168 6.10 134-202

SG: Siemens Dimension Instruments 30 150 2.90 120-180 30 59 2.30 47-71 30 108 2.40 86-130 30 226 3.90 181-271 30 158 3.50 126-190 AG: All Group 71 155 8.30 124-186 68 59 2.80 47-71 71 111 5.00 89-133 72 236 18.10 189-283 72 166 9.80 133-199 ALT (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5

PG: Siemens ADVIA 1800 / Genzyme 1 249 0.00 199-299 1 23 0.00 18-28 1 217 0.00 174-260 1 156 0.00 125-187 1 412 0.00 330-494 PG: Alfa Wasserman ACE 6 142 2.70 114-170 6 10 4.00 8-12 6 123 2.40 98-148 6 87 1.70 70-104 6 236 3.70 189-283

PG: Alfa Wasserman ACE / Other reagent 2 142 0.70 114-170 2 10 4.90 8-12 2 124 0.70 99-149 2 85 2.80 68-102 2 236 1.40 189-283 PG: Beckman Coulter AU series 10 148 4.90 118-178 10 14 1.10 11-17 10 130 9.80 104-156 10 93 3.10 74-112 10 241 8.50 193-289 SG: Beckman Coulter Instruments 21 155 8.70 124-186 21 16 2.60 13-19 21 137 9.70 110-164 21 98 5.80 78-118 21 253 14.60 202-304 PG: Siemens Dimension Xpand 13 175 4.00 140-210 13 20 5.20 16-24 13 153 3.50 122-184 13 112 4.60 90-134 13 285 5.00 228-342 PG: Siemens Dimension Xpand / Siemens

Dimension ALTI 32 175 2.60 140-210 32 18 1.50 14-22 32 153 2.50 122-184 31 111 2.50 89-133 32 286 4.20 229-343

PG: Ortho Diagnostics VITROS 250/400/500 12 171 5.90 137-205 12 37 4.50 30-44 12 155 3.60 124-186 12 106 4.20 85-127 12 285 4.90 228-342 PG: Ortho Diagnostics VITROS 350 33 175 4.60 140-210 33 40 5.10 32-48 33 158 4.60 126-190 33 108 5.20 86-130 33 287 5.60 230-344 PG: Roche cobas c 501 12 160 1.90 128-192 12 16 0.70 13-19 12 139 1.70 111-167 12 100 1.20 80-120 12 265 9.60 212-318 PG: Roche COBAS Integra 12 161 2.60 129-193 12 15 0.80 12-18 12 140 2.50 112-168 12 99 2.20 79-119 12 265 4.70 212-318 PG: Siemens Dimension EXL 25 175 3.80 140-210 25 19 3.60 15-23 25 152 3.50 122-182 24 110 2.10 88-132 25 285 4.50 228-342 PG: Siemens Dimension EXL / Siemens

Dimension ALTI 11 177 2.50 142-212 11 19 1.00 15-23 11 153 3.10 122-184 11 112 2.40 90-134 11 286 6.00 229-343 PG: Alfa Wasserman 600 1 201 0.00 161-241 1 19 0.00 15-23 1 175 0.00 140-210 1 124 0.00 99-149 1 139 0.00 111-167

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

SG: Roche Cobas Instruments 31 161 2.20 129-193 31 15 0.70 12-18 31 140 2.10 112-168 32 100 2.30 80-120 31 265 5.30 212-318

SG: Siemens Dimension Instruments 43 175 4.10 140-210 43 20 4.50 16-24 43 152 3.60 122-182 42 111 3.30 89-133 43 284 6.20 227-341

SG: Siemens Dimension Instruments /

Siemens DimensionALTI 45 176 2.60 141-211 45 18 1.40 14-22 45 153 2.60 122-184 44 111 2.40 89-133 45 286 4.60 229-343 SG: Ortho VITROS Instruments 55 174 4.60 139-209 56 39 5.10 31-47 56 157 4.40 126-188 56 107 4.90 86-128 56 286 5.60 229-343 SG: Beckman Coulter UniCel DxC

Instruments 11 162 3.70 130-194 11 18 1.70 14-22 11 143 4.30 114-172 11 103 3.30 82-124 11 265 6.80 212-318 SG: Architect c Instruments 10 170 4.90 136-204 10 17 2.00 14-20 10 147 4.50 118-176 10 106 3.30 85-127 10 277 7.40 222-332 AG: All Group 218 169 9.70 135-203 221 23 10.20 18-28 219 149 9.90 119-179 218 106 7.20 85-127 218 277 15.40 222-332 Lactate N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Ortho Diagnostics VITROS 350 15 3.6 0.09 3.4-3.8 14 1.4 0.05 1.2-1.6 15 2.5 0.06 2.3-2.7 15 5.5 0.14 5.2-5.8 15 3.7 0.10 3.5-3.9 PG: Siemens Dimension EXL 15 3.8 0.08 3.6-4.0 16 1 0.12 0.8-1.2 16 2.3 0.10 2.1-2.5 16 6.6 0.10 6.4-6.8 16 3.6 0.10 3.4-3.8

SG: Siemens Dimension Instruments 24 3.8 0.11 3.6-4.0 25 1.1 0.15 0.8-1.4 25 2.4 0.14 2.1-2.7 25 6.6 0.17 6.3-6.9 25 3.6 0.13 3.3-3.9 SG: Ortho VITROS Instruments 22 3.6 0.09 3.4-3.8 20 1.4 0.04 1.2-1.6 22 2.5 0.06 2.3-2.7 22 5.5 0.16 5.2-5.8 22 3.6 0.09 3.4-3.8 AG: All Group 67 3.7 0.16 3.4-4.0 65 1.3 0.23 0.8-1.8 68 2.5 0.14 2.2-2.8 68 6.2 0.55 5.1-7.3 68 3.6 0.14 3.3-3.9 LD N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Alfa Wasserman ACE 3 330 14.90 264-396 3 71 4.00 57-85 3 310 10.10 248-372 3 173 7.00 138-208 3 530 12.60 424-636 SG: Beckman Coulter Instruments 18 389 18.40 311-467 18 82 3.90 66-98 18 358 15.90 286-430 18 205 8.90 164-246 18 621 33.60 497-745

PG: Siemens Dimension Xpand / Siemens

RevisedDimension LDI reagent 15 449 5.70 359-539 16 92 5.20 74-110 16 415 8.20 332-498 16 236 6.70 189-283 16 734 17.40 587-881 PG: Roche cobas c 501 10 450 7.50 360-540 11 93 2.40 74-112 11 414 8.30 331-497 11 237 5.10 190-284 11 723 32.80 578-868

PG: Siemens Dimension EXL / Siemens

Revised DimensionLDI reagent 14 453 9.30 362-544 14 93 4.60 74-112 14 418 11.20 334-502 14 239 6.80 191-287 14 735 19.60 588-882 SG: Roche Cobas Instruments 14 453 9.80 362-544 15 94 2.80 75-113 15 417 8.60 334-500 15 239 5.90 191-287 14 719 15.50 575-863

SG: Siemens Dimension Instruments 16 450 13.30 360-540 16 91 4.40 73-109 16 413 8.50 330-496 16 235 7.40 188-282 16 729 20.60 583-875

SG: Siemens Dimension Instruments /

Siemens RevisedDimension LDI reagent 34 453 8.20 362-544 35 93 5.00 74-112 35 419 10.70 335-503 35 238 7.80 190-286 35 738 18.80 590-886 SG: Ortho VITROS Instruments 19 1570 33.10 1256-1884 19 330 10.60 264-396 19 1507 41.50 1206-1808 19 796 21.00 637-955 19 2514 235.10 2011-3017 SG: Beckman Coulter UniCel DxC

Instruments 10 380 9.20 304-456 10 81 2.40 65-97 10 354 7.50 283-425 10 201 4.00 161-241 10 601 12.20 481-721 AG: All Group 112 628 428.80 502-754 113 130 90.30 104-156 113 588 416.30 470-706 113 325 213.50 260-390 113 1010 688.10 808-1212 Lipase N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 17 43 5.40 30-56 17 13 3.10 17-Sep 17 22 2.60 15-29 17 86 16.00 60-112 17 30 2.30 21-39 PG: Ortho Diagnostics VITROS 350 20 668 17.20 468-868 20 87 5.50 61-113 20 284 8.60 199-369 20 1576 35.80 1103-2049 20 457 12.30 320-594 PG: Roche cobas c 501 12 41 2.50 29-53 12 12 0.80 16-Aug 12 21 1.10 15-27 12 90 4.90 63-117 12 30 2.10 21-39 PG: Siemens Dimension EXL / Dimension

LIPL reagent 19 176 4.30 123-229 19 51 3.10 36-66 19 91 3.00 64-118 19 385 7.10 270-501 19 129 3.10 90-168 SG: Roche Cobas Instruments 22 43 2.60 30-56 22 12 0.70 16-Aug 22 21 1.30 15-27 22 93 6.30 65-121 22 31 2.10 22-40

SG: Siemens Dimension Instruments 18 179 13.90 125-233 18 52 4.30 36-68 18 93 7.00 65-121 18 394 35.80 276-512 18 132 8.40 92-172

SG: Siemens Dimension Instruments /

Dimension LIPL reagent 33 174 6.00 122-226 34 51 3.80 36-66 33 91 3.40 64-118 32 382 9.80 267-497 33 128 3.60 90-166 SG: Ortho VITROS Instruments 34 660 20.90 462-858 34 84 6.60 59-109 34 276 14.00 193-359 34 1570 41.60 1099-2041 34 450 17.40 315-585 SG: Beckman Coulter UniCel DxC

Instruments 12 41 1.60 29-53 12 14 1.60 18-Oct 12 22 1.80 15-29 12 77 5.90 54-100 12 30 1.80 21-39 AG: All Group 132 254 245.90 178-330 132 46 28.60 32-60 132 114 100.20 80-148 132 589 592.10 412-766 132 177 166.20 124-230 Lithium N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Siemens Dimension EXL 11 1.3 0.04 1.0-1.6 12 2.8 0.11 2.2-3.4 12 1.9 0.04 1.5-2.3 12 0.6 0.06 0.3-0.9 12 1 0.05 0.7-1.3

SG: Siemens Dimension Instruments 19 1.3 0.04 1.0-1.6 20 2.7 0.15 2.2-3.2 20 1.9 0.06 1.5-2.3 20 0.6 0.07 0.3-0.9 20 1 0.06 0.7-1.3

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

SG: Ortho VITROS Instruments 9 0.8 0.06 0.5-1.1 9 1.8 0.09 1.4-2.2 9 1.3 0.07 1.0-1.6 9 0.2 0.00 0.0-0.5 9 0.7 0.06 0.4-1.0 AG: All Group 45 1.2 0.22 0.9-1.5 46 2.5 0.38 2.0-3.0 46 1.7 0.24 1.4-2.0 46 0.5 0.16 0.2-0.8 46 1 0.16 0.7-1.3 Magnesium N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 17 2.7 0.11 2.0-3.4 16 4.5 0.19 3.4-5.6 17 3 0.14 2.3-3.8 17 3.1 0.12 2.3-3.9 17 1.6 0.13 1.2-2.0 PG: Siemens Dimension Xpand 22 2.7 0.11 2.0-3.4 22 4.7 0.16 3.5-5.9 22 3.1 0.12 2.3-3.9 22 3.1 0.13 2.3-3.9 22 1.5 0.08 1.1-1.9 PG: Ortho Diagnostics VITROS 350 21 2.9 0.07 2.2-3.6 20 5.2 0.12 3.9-6.5 21 3.4 0.09 2.5-4.3 21 3.3 0.11 2.5-4.1 21 1.6 0.09 1.2-2.0 PG: Roche cobas c 501 11 2.7 0.13 2.0-3.4 11 4.5 0.21 3.4-5.6 11 3.1 0.08 2.3-3.9 11 3.1 0.11 2.3-3.9 11 1.5 0.10 1.1-1.9 PG: Siemens Dimension EXL 30 2.7 0.12 2.0-3.4 30 4.7 0.17 3.5-5.9 30 3.1 0.10 2.3-3.9 30 3.2 0.15 2.4-4.0 30 1.5 0.12 1.1-1.9 SG: Roche Cobas Instruments 20 2.7 0.12 2.0-3.4 19 4.6 0.11 3.4-5.8 19 3.1 0.07 2.3-3.9 20 3.1 0.11 2.3-3.9 20 1.5 0.09 1.1-1.9

SG: Siemens Dimension Instruments 59 2.7 0.12 2.0-3.4 59 4.7 0.17 3.5-5.9 59 3.1 0.12 2.3-3.9 59 3.2 0.14 2.4-4.0 59 1.5 0.11 1.1-1.9 SG: Ortho VITROS Instruments 39 2.9 0.11 2.2-3.6 37 5.1 0.16 3.8-6.4 38 3.3 0.11 2.5-4.1 39 3.2 0.16 2.4-4.0 39 1.6 0.10 1.2-2.0 SG: Beckman Coulter UniCel DxC

Instruments 10 2.6 0.12 2.0-3.3 10 4.5 0.08 3.4-5.6 10 3 0.13 2.3-3.8 10 3.1 0.14 2.3-3.9 10 1.5 0.11 1.1-1.9 AG: All Group 148 2.7 0.14 2.0-3.4 144 4.8 0.28 3.6-6.0 147 3.1 0.18 2.3-3.9 149 3.1 0.16 2.3-3.9 148 1.5 0.11 1.1-1.9 Amylase (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 18 90 12.00 63-117 18 20 4.50 14-26 18 77 10.40 54-100 18 73 14.70 51-95 18 134 15.60 94-174 PG: Siemens Dimension Xpand 25 105 1.80 74-137 24 21 0.70 15-27 25 91 1.60 64-118 24 75 1.50 53-98 25 161 2.70 113-209 PG: Ortho Diagnostics VITROS 350 22 52 3.60 36-68 22 30 0.00 21-39 22 38 4.10 27-49 22 63 3.50 44-82 22 72 4.00 50-94 PG: Roche cobas c 501 10 92 1.80 64-120 10 23 0.50 16-30 10 78 1.30 55-101 10 80 1.70 56-104 10 133 5.60 93-173 PG: Roche COBAS Integra 11 92 2.30 64-120 11 23 0.80 16-30 11 78 1.50 55-101 11 80 1.90 56-104 11 131 2.50 92-170 PG: Siemens Dimension EXL 30 104 2.30 73-135 29 21 0.60 15-27 30 91 2.10 64-118 30 75 1.80 53-98 30 161 3.80 113-209 PG: Alfa Wasserman 600 1 116 0.00 81-151 1 36 0.00 25-47 1 97 0.00 68-126 1 116 0.00 81-151 1 159 0.00 111-207 SG: Roche Cobas Instruments 26 92 2.20 64-120 26 23 0.60 16-30 26 78 1.40 55-101 26 80 1.90 56-104 25 132 2.40 92-172

SG: Siemens Dimension Instruments 62 104 2.00 73-135 59 21 0.70 15-27 62 91 1.90 64-118 61 75 1.60 53-98 61 161 3.30 113-209 SG: Ortho VITROS Instruments 36 52 3.60 36-68 37 30 0.00 21-39 37 37 4.20 26-48 36 64 4.30 45-83 37 71 4.40 50-92 SG: Beckman Coulter UniCel DxC

Instruments 10 100 1.60 70-130 10 24 0.80 17-31 10 86 2.10 60-112 10 86 1.50 60-112 10 147 2.40 103-191 AG: All Group 152 88 21.80 62-114 153 24 4.20 17-31 153 74 22.40 52-96 151 74 8.60 52-96 151 130 36.60 91-169 Osmolality, serum N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Advanced Instruments 18 465 5.60 448-482 17 459 3.80 448-470 17 432 5.50 416-449 18 595 9.60 566-624 18 405 3.70 394-416 SG: Osmometers 22 465 5.70 448-482 20 459 3.60 448-470 21 431 5.50 415-448 22 595 10.30 564-626 22 405 4.30 392-418 AG: All Group 30 415 85.20 159-671 29 407 84.50 154-661 29 386 75.30 160-612 30 519 128.20 134-904 30 366 65.90 168-564 Phenobarbital N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 11 27.9 1.50 22.3-33.5 11 7 0.75 5.6-8.4 11 18 1.00 14.4-21.6 11 47.5 2.92 38.0-57.0 11 29.2 1.65 23.4-35.0 PG: Siemens Dimension EXL 11 31 1.60 24.8-37.2 11 7.4 0.79 5.9-8.9 11 20 1.56 16.0-24.0 11 52.4 3.08 41.9-62.9 11 33.1 2.43 26.5-39.7

SG: Siemens Dimension Instruments 19 30.8 1.43 24.6-37.0 19 7.4 0.70 5.9-8.9 19 19.8 1.29 15.8-23.8 19 51.5 2.75 41.2-61.8 19 32.4 2.25 25.9-38.9 AG: All Group 38 29.5 1.95 23.6-35.4 37 7.1 0.80 5.7-8.5 38 18.8 1.54 15.0-22.6 38 49.6 3.31 39.7-59.5 38 31.2 2.48 25.0-37.4 Phenytoin (Dilantin) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 12 20.3 1.60 15.2-25.4 12 7 0.48 5.3-8.8 12 18.6 0.94 14.0-23.3 12 14.7 0.75 11.0-18.4 12 30.5 2.47 22.9-38.1 PG: Siemens Dimension EXL 23 21.3 1.40 16.0-26.6 23 6.6 0.60 4.9-8.3 23 19.3 0.97 14.5-24.1 23 15.5 0.91 11.6-19.4 23 31.9 1.76 23.9-39.9

SG: Siemens Dimension Instruments 35 21.3 1.22 16.0-26.6 35 6.6 0.57 4.9-8.3 35 19.2 0.94 14.4-24.0 35 15.6 0.83 11.7-19.5 35 31.9 1.58 23.9-39.9 SG: Ortho VITROS Instruments 16 21.7 0.86 16.3-27.1 13 6.9 1.23 5.2-8.6 15 20.5 1.53 15.4-25.6 16 14.7 0.89 11.0-18.4 16 32.2 2.04 24.2-40.3 AG: All Group 80 21.1 1.30 15.8-26.4 76 6.9 0.64 5.2-8.6 78 19.3 1.28 14.5-24.1 80 14.9 1.15 11.2-18.6 80 31.3 2.19 23.5-39.1 Phosphorus (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 10 3.1 0.16 2.6-3.6 10 5.1 0.13 4.5-5.7 10 3.4 0.14 2.9-3.9 10 3.8 0.11 3.3-4.3 10 1.8 0.15 1.3-2.3 SG: Beckman Coulter Instruments 19 3.3 0.27 2.8-3.8 19 5.2 0.22 4.6-5.8 19 3.6 0.27 3.1-4.1 19 3.9 0.28 3.4-4.4 19 1.9 0.25 1.4-2.4 PG: Beckman Coulter UniCel DxC 800

Synchron series 2 3.9 0.07 3.4-4.4 2 5.7 0.07 5.0-6.4 2 4.2 0.00 3.7-4.7 2 4.6 0.14 4.0-5.2 2 2.5 0.00 2.0-3.0 PG: Siemens Dimension Xpand 23 3.3 0.11 2.8-3.8 23 5.3 0.08 4.7-5.9 22 3.6 0.07 3.1-4.1 23 4 0.10 3.5-4.5 23 1.9 0.09 1.4-2.4 PG: Ortho Diagnostics VITROS 350 18 3.5 0.12 3.0-4.0 18 5.1 0.14 4.5-5.7 18 3.8 0.12 3.3-4.3 18 4.2 0.12 3.7-4.7 18 2.3 0.11 1.8-2.8 PG: Roche cobas c 501 11 3.3 0.06 2.8-3.8 11 5.3 0.11 4.7-5.9 11 3.6 0.07 3.1-4.1 11 4 0.11 3.5-4.5 11 1.9 0.08 1.4-2.4 PG: Siemens Dimension EXL 34 3.2 0.10 2.7-3.7 34 5.3 0.10 4.7-5.9 34 3.6 0.10 3.1-4.1 34 4 0.10 3.5-4.5 34 1.8 0.11 1.3-2.3 SG: Roche Cobas Instruments 23 3.3 0.07 2.8-3.8 23 5.3 0.11 4.7-5.9 23 3.6 0.08 3.1-4.1 23 3.9 0.11 3.4-4.4 23 1.9 0.08 1.4-2.4

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

SG: Siemens Dimension Instruments 64 3.2 0.09 2.7-3.7 64 5.3 0.10 4.7-5.9 64 3.6 0.08 3.1-4.1 64 4 0.09 3.5-4.5 65 1.8 0.10 1.3-2.3 SG: Ortho VITROS Instruments 31 3.5 0.08 3.0-4.0 32 5.1 0.13 4.5-5.7 32 3.8 0.10 3.3-4.3 32 4.2 0.11 3.7-4.7 32 2.3 0.10 1.8-2.8 AG: All Group 144 3.3 0.16 2.8-3.8 147 5.2 0.16 4.6-5.8 145 3.6 0.14 3.1-4.1 146 4 0.16 3.5-4.5 148 2 0.23 1.5-2.5 Potassium (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 10 4 0.05 3.5-4.5 10 4.4 0.05 3.9-4.9 10 3.5 0.07 3.0-4.0 10 6.5 0.10 6.0-7.0 10 2.6 0.07 2.1-3.1 SG: Beckman Coulter Instruments 21 4 0.06 3.5-4.5 21 4.4 0.06 3.9-4.9 21 3.4 0.07 2.9-3.9 21 6.5 0.12 6.0-7.0 21 2.5 0.08 2.0-3.0 PG: Siemens Dimension Xpand 44 4 0.03 3.5-4.5 43 4.5 0.03 4.0-5.0 45 3.5 0.03 3.0-4.0 44 6.6 0.08 6.1-7.1 45 2.5 0.05 2.0-3.0

PG: Ortho Diagnostics VITROS 250/400/500 12 4.1 0.06 3.6-4.6 12 4.5 0.11 4.0-5.0 12 3.5 0.07 3.0-4.0 12 6.9 0.12 6.4-7.4 12 2.6 0.06 2.1-3.1 PG: Ortho Diagnostics VITROS 350 34 4.1 0.06 3.6-4.6 34 4.5 0.07 4.0-5.0 34 3.5 0.05 3.0-4.0 34 6.9 0.10 6.4-7.4 34 2.6 0.05 2.1-3.1 PG: Roche cobas c 501 12 3.9 0.07 3.4-4.4 12 4.4 0.05 3.9-4.9 12 3.4 0.05 2.9-3.9 12 6.5 0.05 6.0-7.0 12 2.4 0.07 1.9-2.9 PG: Roche COBAS Integra 11 4 0.00 3.5-4.5 12 4.5 0.05 4.0-5.0 12 3.5 0.04 3.0-4.0 12 6.5 0.07 6.0-7.0 12 2.5 0.04 2.0-3.0 PG: Siemens Dimension EXL 36 4 0.04 3.5-4.5 36 4.5 0.05 4.0-5.0 36 3.5 0.04 3.0-4.0 36 6.6 0.07 6.1-7.1 36 2.5 0.04 2.0-3.0 SG: Roche Cobas Instruments 31 4 0.07 3.5-4.5 32 4.4 0.07 3.9-4.9 32 3.4 0.09 2.9-3.9 31 6.5 0.06 6.0-7.0 32 2.5 0.08 2.0-3.0

SG: Siemens Dimension Instruments 87 4 0.04 3.5-4.5 85 4.5 0.04 4.0-5.0 87 3.5 0.04 3.0-4.0 85 6.6 0.07 6.1-7.1 88 2.5 0.05 2.0-3.0 SG: Ortho VITROS Instruments 59 4.1 0.07 3.6-4.6 60 4.5 0.08 4.0-5.0 59 3.5 0.06 3.0-4.0 60 6.9 0.11 6.4-7.4 59 2.6 0.05 2.1-3.1 SG: Beckman Coulter UniCel DxC

Instruments 11 4 0.08 3.5-4.5 11 4.4 0.07 3.9-4.9 11 3.4 0.06 2.9-3.9 11 6.6 0.07 6.1-7.1 11 2.4 0.05 1.9-2.9 SG: Architect c Instruments 10 4 0.06 3.5-4.5 10 4.4 0.07 3.9-4.9 10 3.5 0.07 3.0-4.0 10 6.6 0.06 6.1-7.1 10 2.5 0.06 2.0-3.0 AG: All Group 223 4 0.08 3.5-4.5 220 4.5 0.06 4.0-5.0 225 3.5 0.07 3.0-4.0 223 6.7 0.17 6.2-7.2 226 2.5 0.09 2.0-3.0 Salicylate N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 12 17.7 1.17 13.3-22.1 12 7.2 1.28 5.4-9.0 12 10.7 1.19 8.0-13.4 12 35.9 1.82 26.9-44.9 12 14.7 1.07 11.0-18.4 PG: Siemens Dimension Vista 1 22.1 0.00 16.6-27.6 1 10.5 0.00 7.9-13.1 1 13.3 0.00 10.0-16.6 1 42.2 0.00 31.7-52.8 1 16.8 0.00 12.6-21.0 PG: Ortho Diagnostics VITROS 350 11 19.2 0.70 14.4-24.0 11 9.1 0.38 6.8-11.4 11 12.6 0.54 9.4-15.8 11 34.4 1.07 25.8-43.0 11 16 0.27 12.0-20.0 PG: Siemens Dimension EXL 21 17 0.57 12.8-21.3 21 9.9 0.28 7.4-12.4 21 10.5 0.52 7.9-13.1 21 37.1 0.65 27.8-46.4 21 10.3 0.71 7.7-12.9 SG: Roche Cobas Instruments 14 17 0.43 12.8-21.3 14 7.3 0.53 5.5-9.1 14 10.3 0.46 7.7-12.9 14 33.8 0.98 25.3-42.3 14 13.6 0.64 10.2-17.0

SG: Siemens Dimension Instruments 30 17 0.53 12.8-21.3 31 9.9 0.29 7.4-12.4 30 10.5 0.51 7.9-13.1 30 37.1 0.66 27.8-46.4 30 10.3 0.67 7.7-12.9 SG: Ortho VITROS Instruments 19 19.1 0.75 14.3-23.9 19 9.1 0.47 6.8-11.4 19 12.6 0.67 9.4-15.8 19 34.9 1.64 26.2-43.6 19 16 0.55 12.0-20.0 AG: All Group 79 17.7 1.11 13.3-22.1 80 8.8 1.32 6.6-11.0 79 11 1.12 8.3-13.8 79 35.7 1.71 26.8-44.6 79 13.1 2.45 9.8-16.4 Sodium (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5

PG: Siemens ADVIA 1800 / Other reagent 1 140 0.00 136-144 1 145 0.00 141-149 1 136 0.00 132-140 1 165 0.00 161-169 1 126 0.00 122-130 PG: Beckman Coulter AU series 10 131 1.10 127-135 10 137 0.70 133-141 10 127 0.80 123-131 10 153 1.30 149-157 10 118 1.60 114-122 SG: Beckman Coulter Instruments 21 132 1.80 128-136 21 137 1.70 133-141 21 128 1.50 124-132 21 154 2.40 150-158 21 118 1.80 114-122 PG: Siemens Dimension Xpand 45 135 1.20 131-139 45 140 1.10 136-144 45 130 1.10 126-134 44 156 1.30 152-160 45 121 1.00 117-125

PG: Ortho Diagnostics VITROS 250/400/500 12 137 1.50 133-141 12 140 3.50 136-144 12 131 1.60 127-135 12 166 2.50 162-170 12 123 2.50 119-127 PG: Ortho Diagnostics VITROS 350 34 137 1.90 133-141 34 139 1.70 135-143 34 131 1.60 127-135 34 166 2.10 162-170 34 123 1.60 119-127 PG: Ortho Diagnostics VITROS DT60 / DT60

II 1 132 0.00 128-136 1 134 0.00 130-138 1 126 0.00 122-130 1 162 0.00 158-166 1 117 0.00 113-121 PG: Roche cobas c 501 12 132 1.20 128-136 12 137 1.40 133-141 12 128 0.80 124-132 12 156 1.10 152-160 11 118 3.40 114-122 PG: Roche COBAS Integra 12 132 1.40 128-136 12 137 0.80 133-141 12 128 1.30 124-132 12 154 0.90 150-158 12 118 1.10 114-122 PG: Siemens Dimension EXL 36 134 1.20 130-138 36 140 1.30 136-144 36 130 1.00 126-134 36 156 1.50 152-160 36 121 1.20 117-125 SG: Roche Cobas Instruments 32 132 1.40 128-136 32 137 1.10 133-141 32 127 1.00 123-131 32 155 1.60 151-159 30 118 1.10 114-122

SG: Siemens Dimension Instruments 87 134 1.20 130-138 87 140 1.30 136-144 87 130 1.20 126-134 87 156 1.60 152-160 88 121 1.20 117-125 SG: Beckman Coulter UniCel DxC

Instruments 11 133 2.00 129-137 11 138 2.10 134-142 11 129 1.60 125-133 11 156 2.60 152-160 11 119 1.80 115-123 SG: Architect c Instruments 10 134 1.10 130-138 10 138 1.20 134-142 10 129 0.80 125-133 10 158 1.30 154-162 10 119 1.20 115-123 AG: All Group 224 134 2.20 130-138 223 139 2.00 135-143 225 130 1.90 126-134 224 158 5.00 154-162 222 120 2.20 116-124 T3 Uptake N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 AG: All Group 20 48.88 6.57 29.17-68.59 20 50.8 7.46 28.41-73.19 20 48.84 6.83 28.36-69.32 19 48.41 6.89 27.73-69.09 20 47.09 6.98 26.16-68.02 T4 N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5

PG: Ortho Diagnostics VITROS 5600 2 12.25 0.50 9.80-14.70 2 3.73 0.21 2.73-4.73 2 6.98 0.38 5.58-8.38 2 23.55 0.78 18.84-28.26 2 10.15 0.35 8.12-12.18

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

PG: Ortho Diagnostics VITROS ECi 1 11.8 0.00 9.44-14.16 1 3.66 0.00 2.66-4.66 1 6.53 0.00 5.22-7.84 1 23.7 0.00 18.96-28.44 1 9.5 0.00 7.60-11.40 SG: All Advia Centaur Systems 1 7.55 0.00 6.04-9.06 1 2.05 0.00 1.05-3.05 1 4.1 0.00 3.10-5.10 1 12.7 0.00 10.16-15.24 1 6.1 0.00 4.88-7.32 SG: Roche Cobas Instruments 4 7.22 0.38 5.78-8.66 4 2.81 0.16 1.81-3.81 4 4.54 0.16 3.54-5.54 4 14.33 0.52 11.46-17.20 4 6.12 0.39 4.90-7.34

SG: Siemens Dimension Instruments 11 8.87 0.49 7.10-10.64 11 3.25 0.55 2.25-4.25 11 5.48 0.91 4.38-6.58 11 16.75 0.76 13.40-20.10 11 7.37 0.57 5.90-8.84 AG: All Group 30 8.91 1.42 7.13-10.69 30 3.15 0.58 2.15-4.15 30 5.4 1.01 4.32-6.48 31 17.16 2.72 13.73-20.59 31 7.55 1.25 6.04-9.06 Theophylline N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5

PG: Ortho Diagnostics VITROS 5600 3 47.3 2.65 35.5-59.1 3 32.5 0.40 24.4-40.6 3 47.2 2.66 35.4-59.0 3 23.4 1.01 17.5-29.3 3 66.6 2.77 49.9-83.3 PG: Siemens Dimension EXL 12 28.2 2.01 21.1-35.3 12 15.9 0.87 11.9-19.9 12 29 2.14 21.8-36.3 12 10.9 0.55 8.2-13.6 12 40.5 2.06 30.4-50.6

SG: Siemens Dimension Instruments 20 27.7 2.14 20.8-34.6 20 15.8 0.77 11.9-19.8 20 28.9 1.99 21.7-36.1 20 10.9 0.60 8.2-13.6 20 40.4 2.33 30.3-50.5 AG: All Group 35 27.9 3.51 20.9-34.9 34 15.8 0.92 11.9-19.8 35 29.2 3.27 21.9-36.5 34 10.8 0.76 8.1-13.5 35 41.7 4.80 31.3-52.1 TIBC, measured N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Roche Diagnostics Hitachi 900 series /

Pointe Scientific,Inc. 1 265 0.00 212-318 1 161 0.00 129-193 1 215 0.00 172-258 1 346 0.00 277-415 1 265 0.00 212-318 PG: Siemens Dimension EXL 17 195 10.90 156-234 17 90 10.20 72-108 17 141 10.40 113-169 17 298 9.80 238-358 17 188 10.40 150-226

SG: Siemens Dimension Instruments 30 192 11.70 154-230 30 89 9.60 71-107 29 142 9.80 114-170 29 298 10.70 238-358 30 190 12.00 152-228 SG: Ortho VITROS Instruments 9 207 40.30 166-248 9 146 12.90 117-175 9 182 18.60 146-218 9 239 107.60 191-287 9 212 39.70 170-254 SG: Beckman Coulter UniCel DxC

Instruments 2 279 2.80 223-335 2 143 7.10 114-172 2 213 0.70 170-256 2 421 10.60 337-505 2 276 7.80 221-331 AG: All Group 41 198 24.40 158-238 42 105 28.00 84-126 41 155 25.90 124-186 40 287 51.20 230-344 41 197 24.30 158-236 Tobramycin N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter UniCel DxC

Instruments 4 7.45 0.29 5.59-9.31 4 1.05 0.06 0.79-1.31 4 4.45 0.33 3.34-5.56 4 13.25 0.53 9.94-16.56 4 7.75 0.41 5.81-9.69 AG: All Group 15 6.16 0.95 4.62-7.70 15 0.86 0.29 0.65-1.07 15 3.6 0.61 2.70-4.50 15 11.11 1.68 8.33-13.89 15 6.35 1.02 4.76-7.94 Total protein N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 10 5.6 0.09 5.0-6.2 10 2.9 0.09 2.6-3.2 10 4.2 0.07 3.8-4.6 10 8.7 0.13 7.8-9.6 10 5.4 0.11 4.9-5.9 SG: Beckman Coulter Instruments 21 5.5 0.12 5.0-6.0 20 2.9 0.11 2.6-3.2 21 4.1 0.12 3.7-4.5 21 8.6 0.18 7.7-9.5 21 5.4 0.13 4.9-5.9 PG: Siemens Dimension Xpand 43 5.9 0.09 5.3-6.5 43 3 0.07 2.7-3.3 43 4.4 0.07 4.0-4.8 43 9.2 0.18 8.3-10.1 43 5.7 0.10 5.1-6.3

PG: Ortho Diagnostics VITROS 250/400/500 11 5.5 0.13 5.0-6.0 11 2.9 0.13 2.6-3.2 11 4.2 0.14 3.8-4.6 11 8.2 0.26 7.4-9.0 11 5.6 0.15 5.0-6.2 PG: Ortho Diagnostics VITROS 350 29 5.6 0.11 5.0-6.2 29 2.9 0.08 2.6-3.2 29 4.2 0.10 3.8-4.6 29 8.2 0.17 7.4-9.0 28 5.6 0.10 5.0-6.2 PG: Roche cobas c 501 12 5.6 0.10 5.0-6.2 12 2.9 0.06 2.6-3.2 12 4.2 0.08 3.8-4.6 12 8.7 0.13 7.8-9.6 11 5.4 0.07 4.9-5.9 PG: Roche COBAS Integra 12 5.6 0.12 5.0-6.2 12 2.8 0.11 2.5-3.1 12 4.2 0.09 3.8-4.6 12 8.6 0.24 7.7-9.5 12 5.4 0.12 4.9-5.9 PG: Siemens Dimension EXL 36 5.9 0.09 5.3-6.5 36 3 0.11 2.7-3.3 36 4.3 0.08 3.9-4.7 36 9.2 0.13 8.3-10.1 36 5.7 0.09 5.1-6.3 SG: Roche Cobas Instruments 32 5.7 0.12 5.1-6.3 31 2.9 0.08 2.6-3.2 32 4.2 0.11 3.8-4.6 32 8.7 0.22 7.8-9.6 31 5.4 0.13 4.9-5.9

SG: Siemens Dimension Instruments 85 5.9 0.09 5.3-6.5 84 3 0.07 2.7-3.3 85 4.4 0.07 4.0-4.8 83 9.2 0.12 8.3-10.1 85 5.7 0.09 5.1-6.3 SG: Ortho VITROS Instruments 51 5.6 0.12 5.0-6.2 51 2.9 0.09 2.6-3.2 50 4.2 0.11 3.8-4.6 51 8.2 0.21 7.4-9.0 49 5.6 0.10 5.0-6.2 SG: Beckman Coulter UniCel DxC

Instruments 11 5.4 0.08 4.9-5.9 11 2.7 0.57 2.4-3.0 11 4 0.11 3.6-4.4 11 8.5 0.19 7.7-9.3 11 5.3 0.13 4.8-5.8 SG: Architect c Instruments 10 5.7 0.05 5.1-6.3 10 2.9 0.04 2.6-3.2 10 4.2 0.06 3.8-4.6 10 8.9 0.08 8.0-9.8 10 5.6 0.04 5.0-6.2 AG: All Group 211 5.7 0.18 5.1-6.3 208 2.9 0.11 2.6-3.2 209 4.3 0.13 3.9-4.7 210 8.8 0.43 7.9-9.7 207 5.6 0.15 5.0-6.2 Triglycerides (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 18 143 5.20 107-179 18 87 3.50 65-109 18 101 3.40 76-126 17 256 9.40 192-320 18 115 5.20 86-144 PG: Siemens Dimension Xpand 21 137 2.90 103-171 21 82 1.90 62-103 21 96 2.40 72-120 21 245 4.10 184-306 21 110 2.70 83-138 PG: Ortho Diagnostics VITROS 350 21 164 4.10 123-205 21 96 3.10 72-120 21 113 3.00 85-141 20 299 6.20 224-374 21 130 3.20 98-163 PG: Roche cobas c 501 10 143 2.90 107-179 10 93 2.30 70-116 10 104 2.40 78-130 10 247 3.90 185-309 10 115 5.00 86-144 PG: Roche COBAS Integra 12 137 2.80 103-171 12 90 1.90 68-113 12 99 1.50 74-124 12 239 5.20 179-299 12 108 2.20 81-135 PG: Siemens Dimension EXL 33 138 3.60 104-173 34 81 3.00 61-101 33 96 3.00 72-120 33 244 4.80 183-305 34 111 3.20 83-139 SG: Roche Cobas Instruments 29 139 4.60 104-174 29 91 2.80 68-114 29 101 3.50 76-126 29 243 7.90 182-304 28 110 4.10 83-138

SG: Siemens Dimension Instruments 60 138 3.40 104-173 61 81 2.80 61-101 59 96 2.90 72-120 60 245 4.70 184-306 61 111 3.20 83-139 SG: Ortho VITROS Instruments 40 162 4.60 122-203 40 95 3.00 71-119 40 111 3.40 83-139 39 299 6.60 224-374 40 129 3.50 97-161 SG: Beckman Coulter UniCel DxC

Instruments 10 143 6.80 107-179 10 87 4.40 65-109 10 101 4.40 76-126 10 259 11.30 194-324 10 116 6.70 87-145

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

SG: Architect c Instruments 10 141 1.60 106-176 10 89 1.40 67-111 10 101 1.20 76-126 10 246 3.10 185-308 10 112 1.60 84-140 AG: All Group 175 145 10.90 109-181 176 88 6.40 66-110 174 102 6.70 77-128 172 258 23.80 194-323 173 115 8.70 86-144 TSH N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 13 4.08 0.24 3.37-4.79 13 0.29 0.02 0.23-0.35 13 1.47 0.11 1.13-1.81 13 9.02 0.68 6.98-11.06 13 2.61 0.14 2.18-3.04 PG: Siemens Dimension Xpand 18 4.3 0.26 3.51-5.09 17 0.28 0.02 0.22-0.34 18 1.59 0.11 1.26-1.92 18 10.9 0.82 8.43-13.37 18 2.79 0.19 2.23-3.35 PG: Roche cobas e 411 11 4.69 0.19 4.12-5.26 11 0.43 0.01 0.39-0.47 11 1.85 0.06 1.66-2.04 11 10.68 0.60 8.89-12.47 11 3.04 0.08 2.79-3.29 PG: Siemens Dimension EXL 22 4.33 0.21 3.71-4.95 22 0.33 0.02 0.28-0.38 22 1.58 0.08 1.33-1.83 22 11.32 0.52 9.75-12.89 22 2.73 0.12 2.36-3.10 PG: Siemens Dimension EXL / Siemens LOCI

reagent 12 4.25 0.16 3.78-4.72 12 0.32 0.02 0.26-0.38 12 1.56 0.08 1.31-1.81 12 11.23 0.57 9.51-12.95 12 2.66 0.12 2.31-3.01 PG: TOSOH A1A-360 13 4.95 0.29 4.08-5.82 13 0.36 0.02 0.29-0.43 13 1.86 0.11 1.52-2.20 13 11.94 0.53 10.35-13.53 13 3.22 0.16 2.73-3.71 SG: Roche Cobas Instruments 18 4.76 0.21 4.14-5.38 18 0.43 0.01 0.39-0.47 18 1.87 0.07 1.67-2.07 18 10.87 0.66 8.89-12.85 18 3.09 0.14 2.67-3.51

SG: Siemens Dimension Instruments 47 4.31 0.22 3.64-4.98 46 0.3 0.03 0.20-0.40 47 1.58 0.09 1.31-1.85 47 11.09 0.67 9.09-13.09 47 2.77 0.16 2.30-3.24 SG: Ortho VITROS Instruments 11 5.68 0.25 4.92-6.44 11 0.26 0.02 0.21-0.31 11 2.06 0.09 1.78-2.34 11 13.49 0.37 12.37-14.61 11 3.54 0.11 3.21-3.87 AG: All Group 142 4.55 0.49 3.09-6.01 141 0.33 0.06 0.16-0.50 143 1.69 0.21 1.06-2.32 142 11.15 1.21 7.53-14.77 143 2.93 0.32 1.96-3.90 Urea nitrogen (BUN) - (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Beckman Coulter AU series 10 28 0.80 25-31 10 7 0.30 5-9 10 25 0.70 23-27 10 20 0.50 18-22 10 44 1.40 40-48 SG: Beckman Coulter Instruments 20 28 0.80 25-31 20 7 0.60 5-9 21 25 1.30 23-27 20 19 0.90 17-21 21 43 1.80 39-47 PG: Beckman Coulter UniCel DxC 800

Synchron series 2 25 1.40 23-27 2 5 0.70 3-7 2 22 0.70 20-24 2 15 2.10 13-17 2 39 1.40 35-43 PG: Siemens Dimension Xpand 44 28 0.80 25-31 45 7 0.60 5-9 44 25 0.70 23-27 44 19 0.90 17-21 44 43 1.20 39-47

PG: Ortho Diagnostics VITROS 250/400/500 12 23 0.70 21-25 12 6 0.40 4-8 12 21 0.50 19-23 12 17 0.40 15-19 12 35 1.00 32-38 PG: Ortho Diagnostics VITROS 350 34 23 0.60 21-25 34 6 0.40 4-8 34 20 0.60 18-22 33 17 0.50 15-19 34 34 0.70 31-37 PG: Roche cobas c 501 12 27 0.80 25-29 12 7 0.50 5-9 12 24 0.80 22-26 12 18 0.50 16-20 12 42 1.90 38-46 PG: Roche COBAS Integra 12 27 0.70 25-29 12 6 0.50 4-8 12 24 0.70 22-26 12 18 1.00 16-20 12 42 1.40 38-46 PG: Siemens Dimension EXL 36 28 1.00 25-31 35 7 0.50 5-9 36 25 0.90 23-27 36 19 0.80 17-21 35 44 1.50 40-48 SG: Roche Cobas Instruments 31 27 0.80 25-29 32 7 0.60 5-9 32 24 1.00 22-26 32 18 0.90 16-20 32 42 1.70 38-46

SG: Siemens Dimension Instruments 86 28 0.90 25-31 85 7 0.50 5-9 87 25 0.80 23-27 86 19 0.70 17-21 86 44 1.30 40-48 SG: Ortho VITROS Instruments 60 23 0.60 21-25 60 6 0.40 4-8 60 20 0.60 18-22 59 17 0.60 15-19 60 34 0.90 31-37 SG: Architect c Instruments 10 28 0.40 25-31 10 7 0.30 5-9 10 25 0.70 23-27 10 19 0.70 17-21 10 44 1.00 40-48 AG: All Group 221 27 2.40 25-29 221 7 0.70 5-9 225 24 2.30 22-26 222 18 1.20 16-20 222 41 4.20 37-45 Uric acid N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Alfa Wasserman ACE 4 9.2 0.24 7.6-10.8 4 7.2 0.18 6.0-8.4 4 10.2 0.10 8.5-11.9 4 3.9 0.10 3.2-4.6 4 13.4 0.30 11.1-15.7

PG: Alfa Wasserman ACE / Other reagent 1 9.4 0.00 7.8-11.0 1 7.2 0.00 6.0-8.4 1 10.4 0.00 8.6-12.2 1 3.9 0.00 3.2-4.6 1 13.2 0.00 11.0-15.4 SG: Beckman Coulter Instruments 18 8.9 0.52 7.4-10.4 18 6.9 0.25 5.7-8.1 18 10.1 0.60 8.4-11.8 18 2.4 0.06 2.0-2.8 18 13.1 1.08 10.9-15.3 PG: Siemens Dimension Xpand 30 8.9 0.16 7.4-10.4 30 6.5 0.14 5.4-7.6 30 9.9 0.19 8.2-11.6 27 2.7 0.17 2.2-3.2 30 13.3 0.26 11.0-15.6 PG: Ortho Diagnostics VITROS 350 13 8.6 0.14 7.1-10.1 13 6.2 0.14 5.1-7.3 13 9.5 0.20 7.9-11.1 13 2.4 0.08 2.0-2.8 13 13 0.28 10.8-15.2 PG: Roche cobas c 501 11 9 0.23 7.5-10.5 11 6.7 0.15 5.6-7.8 11 10 0.23 8.3-11.7 11 2.4 0.07 2.0-2.8 11 13.6 0.62 11.3-15.9 PG: Roche COBAS Integra 11 8.8 0.20 7.3-10.3 11 6.6 0.16 5.5-7.7 11 9.9 0.26 8.2-11.6 11 2.3 0.05 1.9-2.7 11 13.2 0.35 11.0-15.4 PG: Siemens Dimension EXL 35 8.9 0.16 7.4-10.4 35 6.5 0.15 5.4-7.6 35 9.9 0.20 8.2-11.6 34 2.8 0.11 2.3-3.3 35 13.3 0.25 11.0-15.6 SG: Roche Cobas Instruments 26 8.9 0.22 7.4-10.4 26 6.7 0.17 5.6-7.8 26 10 0.27 8.3-11.7 26 2.3 0.08 1.9-2.7 25 13.3 0.30 11.0-15.6

SG: Siemens Dimension Instruments 72 8.9 0.17 7.4-10.4 72 6.5 0.14 5.4-7.6 72 9.9 0.20 8.2-11.6 68 2.8 0.13 2.3-3.3 72 13.3 0.25 11.0-15.6 SG: Ortho VITROS Instruments 30 8.7 0.21 7.2-10.2 30 6.3 0.17 5.2-7.4 29 9.6 0.24 8.0-11.2 30 2.4 0.09 2.0-2.8 30 13.1 0.28 10.9-15.3 SG: Architect c Instruments 10 9.3 0.25 7.7-10.9 10 6.8 0.17 5.6-8.0 10 10.5 0.32 8.7-12.3 10 2.5 0.05 2.1-2.9 10 14.2 0.48 11.8-16.6 AG: All Group 164 8.9 0.30 7.4-10.4 164 6.6 0.26 5.5-7.7 164 9.9 0.37 8.2-11.6 154 2.5 0.23 2.1-2.9 163 13.3 0.47 11.0-15.6 Valproic acid N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Siemens Dimension EXL 17 70.3 2.26 52.7-87.9 17 76.3 2.31 57.2-95.4 17 57.9 1.66 43.4-72.4 17 123 3.90 92.3-153.8 17 38.8 1.59 29.1-48.5

SG: Siemens Dimension Instruments 29 70.2 2.16 52.7-87.8 29 76.7 2.30 57.5-95.9 29 58.3 1.66 43.7-72.9 29 124.6 4.39 93.4-155.8 29 39 1.34 29.3-48.8 AG: All Group 60 71.5 3.44 53.6-89.4 61 79.7 4.55 59.8-99.6 61 59.3 2.75 44.5-74.1 61 128.9 7.03 96.7-161.1 60 39 1.93 29.3-48.8 Vancomycin N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 12 28.7 2.20 21.5-35.9 12 3.8 0.39 2.8-4.8 12 15.9 0.73 11.9-19.9 12 53.8 5.39 40.3-67.3 12 30.4 2.24 22.8-38.0 PG: Roche COBAS Integra 4 38.4 1.24 28.8-48.0 4 7.4 1.33 4.7-10.1 4 22.3 1.12 16.7-27.9 4 66.7 4.96 50.0-83.4 4 40.5 1.95 30.4-50.6 PG: Siemens Dimension EXL 20 27 0.82 20.3-33.8 20 3.3 0.33 2.5-4.1 20 15.7 0.39 11.8-19.6 20 47.5 1.17 35.6-59.4 20 27.6 0.81 20.7-34.5

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

SG: Siemens Dimension Instruments 30 26.9 0.61 20.2-33.6 31 3.4 0.39 2.5-4.3 31 15.8 0.35 11.9-19.8 31 47.6 1.29 35.7-59.5 31 27.6 0.79 20.7-34.5 AG: All Group 63 27.8 2.45 20.9-34.8 64 3.9 0.80 2.3-5.5 63 16.1 1.01 12.1-20.1 63 49.5 4.29 37.1-61.9 63 28.6 2.31 21.5-35.8 Aspartate transferase (AST) - (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Alfa Wasserman ACE 7 141 5.50 113-169 7 10 1.40 8-12 7 123 5.90 98-148 7 83 4.10 66-100 7 242 5.90 194-290

PG: Alfa Wasserman ACE / Other reagent 2 140 0.70 112-168 2 10 1.40 8-12 2 122 4.90 98-146 2 80 4.20 64-96 2 242 9.20 194-290 PG: Beckman Coulter AU series 10 133 6.30 106-160 10 14 1.30 11-17 10 116 5.80 93-139 10 82 4.40 66-98 10 224 9.20 179-269 SG: Beckman Coulter Instruments 21 142 9.80 114-170 21 15 1.70 12-18 21 124 9.70 99-149 21 88 6.70 70-106 21 237 15.70 190-284 PG: Siemens Dimension Xpand 45 185 4.80 148-222 44 23 1.50 18-28 45 160 3.30 128-192 44 123 3.10 98-148 45 300 6.10 240-360

PG: Ortho Diagnostics VITROS 250/400/500 11 184 4.80 147-221 11 22 0.90 18-26 11 157 5.10 126-188 11 127 3.40 102-152 11 301 11.20 241-361 PG: Ortho Diagnostics VITROS 350 30 183 6.40 146-220 30 21 0.90 17-25 30 157 5.30 126-188 29 126 4.50 101-151 29 299 10.90 239-359 PG: Roche cobas c 501 12 157 6.40 126-188 12 16 1.00 13-19 12 137 5.20 110-164 12 95 4.30 76-114 12 267 15.60 214-320 PG: Roche COBAS Integra 12 157 4.70 126-188 12 16 1.20 13-19 12 137 4.60 110-164 12 94 3.70 75-113 11 263 6.00 210-316 PG: Siemens Dimension EXL 36 181 4.60 145-217 36 23 1.70 18-28 36 157 4.10 126-188 36 120 3.90 96-144 36 291 6.80 233-349 SG: Roche Cobas Instruments 31 157 6.10 126-188 32 16 1.10 13-19 31 137 5.40 110-164 32 95 5.00 76-114 29 263 8.60 210-316

SG: Siemens Dimension Instruments 87 183 4.90 146-220 87 23 1.60 18-28 87 159 3.70 127-191 87 122 3.70 98-146 87 296 7.10 237-355 SG: Ortho VITROS Instruments 52 183 6.00 146-220 52 21 0.90 17-25 52 157 5.20 126-188 50 126 4.00 101-151 51 298 11.00 238-358 SG: Beckman Coulter UniCel DxC

Instruments 11 149 5.40 119-179 11 16 1.30 13-19 11 131 5.30 105-157 11 93 4.00 74-112 11 248 10.20 198-298 SG: Architect c Instruments 10 153 5.10 122-184 10 16 0.60 13-19 10 134 4.20 107-161 10 95 3.20 76-114 10 256 8.60 205-307 AG: All Group 215 172 17.60 138-206 218 20 4.00 16-24 215 149 14.50 119-179 216 112 16.30 90-134 212 282 24.70 226-338 Acetaminophen N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 12 38 1.70 29-48 12 8 2.60 6-10 12 10 1.20 8-13 12 122 9.10 92-153 12 15 1.50 11-19PG: Ortho Diagnostics VITROS 350 11 44 0.90 33-55 12 9 1.30 7-11 12 14 0.80 11-18 12 114 2.00 86-143 12 19 0.50 14-24PG: Siemens Dimension EXL 23 39 1.00 29-49 23 19 0.80 14-24 23 16 0.70 12-20 23 115 1.70 86-144 23 13 0.80 10-16SG: Roche Cobas Instruments 14 33 1.50 25-41 14 11 5.50 0-15 14 13 3.30 0-15 14 43 25.10 32-54 14 14 1.30 11-18

SG: Siemens Dimension Instruments 33 39 1.20 29-49 33 20 0.90 15-25 33 16 0.80 12-20 33 116 2.40 87-145 33 13 0.90 10-16SG: Ortho VITROS Instruments 19 44 0.80 33-55 20 9 1.20 7-11 20 14 0.70 11-18 20 114 1.80 86-143 20 19 0.50 14-24AG: All Group 81 39 3.70 29-49 82 14 5.80 11-18 82 14 2.70 11-18 82 104 29.70 78-130 82 15 2.60 11-19Bilirubin, direct N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Alfa Wasserman ACE 3 2.1 0.06 1.7-2.5 3 0.2 0.07 0.0-0.6 3 1.7 0.05 1.3-2.1 3 1.8 0.01 1.4-2.2 3 3.1 0.05 2.5-3.7

PG: Alfa Wasserman ACE / Other reagent 1 2.2 0.00 1.8-2.6 1 0.1 0.00 0.0-0.5 1 1.8 0.00 1.4-2.2 1 1.9 0.00 1.5-2.3 1 3.2 0.00 2.6-3.8 PG: Beckman Coulter AU series 8 25.9 67.5 20.7-31.1 8 0.1 0.05 0.0-0.5 8 1.7 0.12 1.3-2.1 8 1.7 0.19 1.3-2.1 8 3.0 0.16 2.4-3.6 PG: Siemens Dimension Xpand 14 1.3 0.09 0.9-1.7 14 0.1 0.06 0.0-0.5 14 1.1 0.06 0.7-1.5 14 1 0.07 0.6-1.4 14 2.1 0.10 1.7-2.5

PG: Siemens Dimension Xpand / Dimension

revised DirectBilirubin method 29 1.3 0.09 0.9-1.7 28 0.1 0.05 0.0-0.5 29 1.1 0.07 0.7-1.5 28 1 0.07 0.6-1.4 29 2.1 0.09 1.7-2.5 PG: Ortho Diagnostics VITROS 350 26 1.2 0.10 0.8-1.6 25 0.0 0.00 0.0-0.4 26 1 0.09 0.6-1.4 25 0.9 0.09 0.5-1.3 26 2.2 0.12 1.8-2.6 PG: Roche cobas c 501 11 1.4 0.05 1.0-1.8 11 0.1 0.08 0.0-0.5 11 1.2 0.06 0.8-1.6 10 1 0.00 0.6-1.4 11 2.2 0.08 1.8-2.6 PG: Roche COBAS Integra 12 1.3 0.08 0.9-1.7 12 0.1 0.05 0.0-0.5 12 1.1 0.05 0.7-1.5 12 1.1 0.05 0.7-1.5 12 2.1 0.10 1.7-2.5 PG: Siemens Dimension EXL 11 1.3 0.05 0.9-1.7 11 0.1 0.05 0.0-0.5 11 1.1 0.05 0.7-1.5 11 1 0.05 0.6-1.4 11 2.1 0.07 1.7-2.5

PG: Siemens Dimension EXL / Dimension

revised DirectBilirubin method 24 1.3 0.06 0.9-1.7 22 0.1 0.05 0.0-0.5 24 1.1 0.06 0.7-1.5 24 1 0.06 0.6-1.4 24 2.1 0.13 1.7-2.5 SG: Roche Cobas Instruments 28 1.3 0.07 0.9-1.7 28 0.1 0.07 0.0-0.5 28 1.2 0.08 0.8-1.6 27 1 0.07 0.6-1.4 28 2.2 0.10 1.8-2.6

SG: Siemens Dimension Instruments 27 1.3 0.07 0.9-1.7 27 0.1 0.05 0.0-0.5 27 1.1 0.06 0.7-1.5 27 1 0.07 0.6-1.4 27 2.1 0.09 1.7-2.5

SG: Siemens Dimension Instruments /

Dimension revisedDirect Bilirubin method 59 1.3 0.07 0.9-1.7 57 0.1 0.05 0.0-0.5 58 1.1 0.05 0.7-1.5 59 1 0.06 0.6-1.4 60 2.1 0.11 1.7-2.5 SG: Ortho VITROS Instruments 45 1.3 0.12 0.9-1.7 42 0.00 0.00 0.0-0.4 45 1 0.10 0.6-1.4 42 0.9 0.10 0.5-1.3 43 2.3 0.14 1.8-2.8 SG: Beckman Coulter UniCel DxC

Instruments 14 1.4 0.07 1.0-1.8 14 0.1 0.03 0.0-0.5 14 1.2 0.05 0.8-1.6 14 1.1 0.06 0.7-1.5 14 2.1 0.10 1.7-2.5

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

SG: Architect c Instruments 7 2.0 0.21 1.6-2.4 7 0.1 0.04 0.0-0.5 7 1.7 0.21 1.3-2.1 7 1.7 0.19 1.3-2.1 7 3.0 0.23 2.4-3.6 AG: All Group 180 1.3 0.14 0.9-1.7 187 0.1 0.06 0.0-0.5 180 1.1 0.14 0.7-1.5 186 1.1 0.22 0.7-1.5 181 2.2 0.20 1.8-2.6 Bilirubin, total (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Alfa Wasserman ACE 8 3.8 0.13 3.0-4.6 8 0.3 0.04 0.0-0.7 8 3.1 0.13 2.5-3.7 8 3.4 0.12 2.7-4.1 8 5.8 0.23 4.6-7.0

PG: Alfa Wasserman ACE / Other reagent 1 3.8 0.00 3.0-4.6 1 0.3 0.00 0.0-0.7 1 3.2 0.00 2.6-3.8 1 3.5 0.00 2.8-4.2 1 5.9 0.00 4.7-7.1 PG: Beckman Coulter AU series 10 3.5 0.14 2.8-4.2 10 0.2 0.05 0.0-0.6 10 2.8 0.11 2.2-3.4 10 2.9 0.14 2.3-3.5 10 5.4 0.23 4.3-6.5 SG: Beckman Coulter Instruments 21 3.6 0.17 2.9-4.3 21 0.3 0.09 0.0-0.7 21 2.9 0.13 2.3-3.5 21 3.2 0.31 2.6-3.8 21 5.4 0.22 4.3-6.5 PG: Siemens Dimension Xpand 15 3.2 0.14 2.6-3.8 15 0.1 0.05 0.0-0.5 15 2.5 0.09 2.0-3.0 15 2.8 0.10 2.2-3.4 15 4.9 0.20 3.9-5.9

PG: Siemens Dimension Xpand / Dimension

revised TotalBilirubin method 30 3.2 0.11 2.6-3.8 30 0.1 0.04 0.0-0.5 30 2.5 0.08 2.0-3.0 29 2.8 0.09 2.2-3.4 30 4.9 0.14 3.9-5.9

PG: Ortho Diagnostics VITROS 250/400/500 11 3.4 0.17 2.7-4.1 11 0.1 0.04 0.0-0.5 11 2.7 0.15 2.2-3.2 11 3.1 0.17 2.5-3.7 11 5.4 0.25 4.3-6.5 PG: Ortho Diagnostics VITROS 350 30 3.4 0.16 2.7-4.1 29 0.1 0.06 0.0-0.5 29 2.7 0.13 2.2-3.2 30 3.1 0.16 2.5-3.7 30 5.4 0.23 4.3-6.5 PG: Roche cobas c 501 12 3 0.20 2.4-3.6 12 0.1 0.00 0.0-0.5 12 2.4 0.08 1.9-2.9 12 2.6 0.09 2.1-3.1 12 4.8 0.21 3.8-5.8 PG: Roche COBAS Integra 12 2.9 0.12 2.3-3.5 11 0.1 0.00 0.0-0.5 12 2.3 0.08 1.8-2.8 12 2.4 0.11 1.9-2.9 12 4.5 0.20 3.6-5.4 PG: Siemens Dimension EXL 12 3.2 0.11 2.6-3.8 12 0.1 0.00 0.0-0.5 12 2.5 0.08 2.0-3.0 12 2.8 0.10 2.2-3.4 12 4.9 0.18 3.9-5.9

PG: Siemens Dimension EXL / Dimension

revised TotalBilirubin method 24 3.2 0.14 2.6-3.8 24 0.1 0.04 0.0-0.5 24 2.5 0.12 2.0-3.0 24 2.8 0.13 2.2-3.4 24 4.9 0.20 3.9-5.9 SG: Roche Cobas Instruments 32 2.9 0.18 2.3-3.5 30 0.1 0.00 0.0-0.5 31 2.4 0.11 1.9-2.9 31 2.5 0.14 2.0-3.0 31 4.7 0.24 3.8-5.6

SG: Siemens Dimension Instruments 27 3.2 0.10 2.6-3.8 28 0.1 0.04 0.0-0.5 28 2.5 0.09 2.0-3.0 28 2.8 0.10 2.2-3.4 28 4.9 0.18 3.9-5.9

SG: Siemens Dimension Instruments /

Dimension revisedTotal Bilirubin method 60 3.2 0.12 2.6-3.8 60 0.1 0.04 0.0-0.5 59 2.5 0.09 2.0-3.0 59 2.8 0.11 2.2-3.4 60 4.9 0.17 3.9-5.9 SG: Ortho VITROS Instruments 52 3.4 0.18 2.7-4.1 50 0.1 0.05 0.0-0.5 51 2.7 0.15 2.2-3.2 52 3 0.18 2.4-3.6 52 5.4 0.25 4.3-6.5 SG: Beckman Coulter UniCel DxC

Instruments 11 3.7 0.13 3.0-4.4 11 0.3 0.09 0.0-0.7 11 2.9 0.13 2.3-3.5 11 3.4 0.19 2.7-4.1 11 5.5 0.21 4.4-6.6 SG: Architect c Instruments 10 3 0.24 2.4-3.6 10 0.2 0.05 0.0-0.6 10 2.5 0.20 2.0-3.0 10 2.7 0.18 2.2-3.2 10 4.5 0.24 3.6-5.4 AG: All Group 213 3.3 0.27 2.6-4.0 211 0.1 0.08 0.0-0.5 212 2.6 0.21 2.1-3.1 214 2.9 0.28 2.3-3.5 214 5 0.39 4.0-6.0 Calcium, total (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 19 11.5 0.23 10.5-12.5 19 9.8 0.12 8.8-10.8 20 12.1 0.26 11.1-13.1 20 7.8 0.24 6.8-8.8 19 14.4 0.22 13.4-15.4 PG: Siemens Dimension Xpand 45 11.4 0.21 10.4-12.4 45 9.7 0.19 8.7-10.7 45 12 0.22 11.0-13.0 44 7.4 0.17 6.4-8.4 45 14.4 0.33 13.4-15.4 PG: Ortho Diagnostics VITROS 350 31 11.6 0.22 10.6-12.6 32 9.6 0.20 8.6-10.6 32 12.2 0.21 11.2-13.2 32 7.1 0.19 6.1-8.1 31 14.8 0.62 13.8-15.8 PG: Roche cobas c 501 11 11.8 0.23 10.8-12.8 11 9.9 0.22 8.9-10.9 11 12.5 0.27 11.5-13.5 11 7.9 0.14 6.9-8.9 11 15.2 0.71 14.2-16.2 PG: Roche COBAS Integra 12 11.9 0.23 10.9-12.9 12 10 0.24 9.0-11.0 12 12.5 0.22 11.5-13.5 12 7.7 0.19 6.7-8.7 12 14.9 0.22 13.9-15.9 PG: Siemens Dimension EXL 36 11.4 0.20 10.4-12.4 36 9.7 0.19 8.7-10.7 36 12.1 0.21 11.1-13.1 36 7.4 0.14 6.4-8.4 36 14.4 0.32 13.4-15.4 SG: Roche Cobas Instruments 31 11.9 0.25 10.9-12.9 31 9.9 0.24 8.9-10.9 31 12.4 0.25 11.4-13.4 31 7.8 0.19 6.8-8.8 30 14.9 0.31 13.9-15.9

SG: Siemens Dimension Instruments 88 11.4 0.20 10.4-12.4 88 9.7 0.19 8.7-10.7 88 12.1 0.21 11.1-13.1 88 7.4 0.33 6.4-8.4 87 14.4 0.32 13.4-15.4 SG: Ortho VITROS Instruments 50 11.6 0.22 10.6-12.6 51 9.6 0.20 8.6-10.6 50 12.2 0.20 11.2-13.2 51 7.2 0.18 6.2-8.2 50 14.8 0.65 13.8-15.8 SG: Beckman Coulter UniCel DxC

Instruments 10 11.5 0.14 10.5-12.5 11 9.8 0.09 8.8-10.8 11 12.1 0.17 11.1-13.1 11 7.6 0.13 6.6-8.6 11 14.3 0.20 13.3-15.3 SG: Architect c Instruments 10 11.9 0.31 10.9-12.9 10 9.9 0.28 8.9-10.9 10 12.4 0.33 11.4-13.4 10 8 0.19 7.0-9.0 10 14.8 0.45 13.8-15.8 AG: All Group 214 11.6 0.28 10.6-12.6 215 9.8 0.24 8.8-10.8 215 12.2 0.27 11.2-13.2 214 7.5 0.32 6.5-8.5 209 14.6 0.47 13.6-15.6 Carbemazepine N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Siemens Dimension EXL 16 10.8 0.36 8.1-13.5 17 3.3 0.13 2.5-4.1 17 9.5 0.25 7.1-11.9 17 8.2 0.30 6.1-10.3 17 15.7 0.36 11.8-19.6

SG: Siemens Dimension Instruments 25 10.7 0.38 8.0-13.4 25 3.3 0.13 2.5-4.1 26 9.5 0.28 7.1-11.9 26 8.2 0.32 6.1-10.3 26 15.8 0.42 11.9-19.8 SG: Ortho VITROS Instruments 13 9.3 0.65 7.0-11.6 13 3 0.00 2.3-3.8 13 8.2 0.51 6.1-10.3 13 7.3 0.72 5.5-9.1 13 14.7 1.07 11.0-18.4 AG: All Group 60 10.4 0.86 7.8-13.0 58 3.3 0.31 2.5-4.1 61 9.4 0.84 7.1-11.8 60 8 0.62 6.0-10.0 59 15.7 0.93 11.8-19.6

Chloride (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5

PG: Siemens ADVIA 1800 / Other reagent 1 108 0.00 103-113 1 114 0.00 108-120 1 104 0.00 99-109 1 130 0.00 124-137 1 93 0.00 88-98 SG: Beckman Coulter Instruments 20 100 1.30 95-105 20 107 1.70 102-112 20 97 1.20 92-102 20 118 1.80 112-124 20 88 1.60 84-92

PG=Peer Group SG=Special Group AG=All Methods Group

2014 Chem/Endo/Tx1

PG: Siemens Dimension Xpand 45 103 2.00 98-108 45 112 2.50 106-118 45 100 1.80 95-105 44 126 2.70 120-132 45 87 1.20 83-91

PG: Ortho Diagnostics VITROS 250/400/500 11 98 1.60 93-103 11 104 2.60 99-109 11 95 0.90 90-100 11 118 2.00 112-124 11 87 1.60 83-91 PG: Ortho Diagnostics VITROS 350 31 98 1.40 93-103 32 104 1.60 99-109 32 95 1.30 90-100 32 117 1.50 111-123 32 87 1.20 83-91 PG: Roche cobas c 501 12 97 1.00 92-102 12 106 1.10 101-111 12 94 0.70 89-99 12 120 1.40 114-126 12 83 2.30 79-87 PG: Roche COBAS Integra 12 101 0.70 96-106 12 108 0.80 103-113 12 98 1.40 93-103 12 122 1.50 116-128 12 87 1.40 83-91 PG: Roche COBAS MIRA 1 109 0.00 104-114 1 110 0.00 105-116 1 101 0.00 96-106 1 140 0.00 133-147 1 92 0.00 87-97 PG: Siemens Dimension EXL 35 102 1.80 97-107 35 111 2.20 105-117 35 99 1.50 94-104 35 125 2.40 119-131 35 86 1.30 82-90 SG: Roche Cobas Instruments 31 99 2.40 94-104 32 107 1.80 102-112 32 96 2.40 91-101 31 121 1.90 115-127 32 85 3.10 81-89

SG: Siemens Dimension Instruments 86 103 2.00 98-108 86 111 2.50 105-117 85 99 1.90 94-104 85 126 2.70 120-132 86 87 1.40 83-91 SG: Ortho VITROS Instruments 53 98 1.50 93-103 53 104 1.50 99-109 54 95 1.20 90-100 52 117 1.40 111-123 53 87 1.10 83-91 SG: Beckman Coulter UniCel DxC

Instruments 11 100 1.40 95-105 11 107 1.80 102-112 11 97 1.40 92-102 11 117 1.50 111-123 11 89 1.60 85-93 SG: Architect c Instruments 10 100 0.70 95-105 10 107 0.90 102-112 10 98 0.70 93-103 10 118 1.00 112-124 10 89 0.70 85-93 AG: All Group 217 101 2.80 96-106 216 108 3.70 103-113 217 97 2.40 92-102 214 122 4.50 116-128 213 87 1.90 83-91 Cholesterol, HDL (NW) N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 SG: Beckman Coulter Instruments 18 99 12.30 69-129 18 66 11.10 46-86 18 89 13.20 62-116 18 107 10.00 75-139 18 114 15.80 80-148 PG: Siemens Dimension Xpand 17 85 2.60 60-111 17 60 1.40 42-78 17 81 1.40 57-105 17 73 3.90 51-95 17 101 2.20 71-131 PG: Ortho Diagnostics VITROS 350 21 99 4.20 69-129 21 59 2.30 41-77 21 87 3.80 61-113 21 105 9.30 74-137 21 121 6.30 85-157 PG: Roche cobas c 501 10 93 1.80 65-121 10 65 1.40 46-85 10 87 2.10 61-113 10 84 2.40 59-109 10 108 5.20 76-140 PG: Roche COBAS Integra 11 94 3.70 66-122 11 67 2.30 47-87 11 89 2.40 62-116 11 84 6.50 59-109 11 110 3.50 77-143 PG: Siemens Dimension EXL 30 85 2.80 60-111 30 60 1.70 42-78 30 82 2.20 57-107 30 73 3.80 51-95 30 101 3.30 71-131 SG: Roche Cobas Instruments 28 93 3.10 65-121 27 66 2.10 46-86 28 88 2.70 62-114 28 84 5.10 59-109 28 109 4.30 76-142

SG: Siemens Dimension Instruments 62 85 3.20 60-111 61 60 1.70 42-78 62 82 2.30 57-107 62 73 4.60 51-95 62 101 3.00 71-131 SG: Ortho VITROS Instruments 37 100 6.00 70-130 37 59 2.70 41-77 37 88 4.50 62-114 37 108 10.60 76-140 37 122 7.10 85-159 SG: Beckman Coulter UniCel DxC

Instruments 10 109 4.30 76-142 10 75 2.50 53-98 10 100 2.80 70-130 10 115 4.00 81-150 10 127 4.70 89-165 SG: Architect c Instruments 10 83 4.30 58-108 10 53 2.80 37-69 10 75 4.00 53-98 10 94 4.20 66-122 10 96 3.70 67-125 AG: All Group 172 91 8.80 64-118 172 61 5.80 43-79 174 84 7.50 59-109 172 89 16.10 62-116 173 107 11.70 75-139 Cholesterol, LDL - measured N Mean SD CET-1 N Mean SD CET-2 N Mean SD CET-3 N Mean SD CET-4 N Mean SD CET-5 PG: Siemens Dimension Vista 1 69 0.00 48-90 1 36 0.00 25-47 1 50 0.00 35-65 1 100 0.00 70-130 1 63 0.00 44-82 SG: Roche Cobas Instruments 8 71 3.30 50-92 8 38 2.10 27-49 8 53 2.50 37-69 8 111 4.60 78-144 8 70 4.50 49-91

SG: Siemens Dimension Instruments 13 51 2.40 36-66 14 27 3.60 19-35 14 37 4.50 26-48 14 88 4.40 62-114 13 46 2.70 32-60 AG: All Group 37 53 11.70 37-69 38 28 7.10 20-36 38 38 10.30 27-49 38 89 14.70 62-116 37 49 13.70 34-64

PG=Peer Group SG=Special Group AG=All Methods Group

Scoring Group Result Result Result Result Result

Acetone, serum (qualitative) AM-1 N % AM-2 N % AM-3 N % AM-4 N % AM-5 N %

Acetest Positive 40 85 Positive 40 88 Negative 40 100 Positive 40 100 Negative 40 100

GC Mass Spectometry Positive 1 100 Positive 1 100 Negative 1 100 Positive 1 100 Negative 1 100

Acetone, serum (semi-quant) AM-1 N % AM-2 N % AM-3 N % AM-4 N % AM-5 N %

Acetest Trace 20 22 Trace 18 20 Negative 94 100 Small (1+) 15 16 Negative 94 100

Small (1+) 52 55 Small (1+) 52 55 Mod (2+) 50 54

Mod (2+) 4 4 Mod (2+) 5 5 Large (3+) 29 30

*Negative 18 19 *Negative 19 20

Siemens (Bayer) Ketostix Trace 1 33 Trace 1 33 Negative 3 100 Small (1+) 1 33 Negative 2 67

*Negative 2 67 *Negative 2 67 Mod (2+) 2 67 *Small (1+) 1 33

hCG, serum (qualitative) HCG-1 N % HCG-2 N % HCG-3 N % HCG-4 N % HCG-5 N %

Beckman Coulter Icon 20 Positive 12 100 Positive 12 100 Negative 12 100 Negative 12 100 Positive 12 100

Beckman Coulter Icon 25 Positive 12 100 Positive 12 100 Negative 12 100 Negative 12 100 Positive 12 100

Cardinal Health SP Brand hCG Positive 19 100 Positive 19 100 Negative 19 100 Negative 19 100 Positive 19 100

Sure-Vue (Non-waived) Positive 48 100 Positive 48 100 Negative 48 98 Negative 48 100 Positive 48 100

Nova Century Scientific - HCG Positive 26 100 Positive 26 100 Negative 26 100 Negative 26 96 Positive 26 96

OSOM hCG Combo Positive 33 100 Positive 33 100 Negative 33 100 Negative 33 100 Positive 33 100

Quidel QuickVue One-Step Combo Positive 43 100 Positive 43 100 Negative 43 98 Negative 43 98 Positive 43 100

Quidel QuickVue+ (Non-waived) Positive 72 100 Positive 72 100 Negative 72 100 Negative 72 100 Positive 72 100

All Methods Positive 329 100 Positive 329 100 Negative 329 99 Negative 329 99 Positive 329 100

Amphetamines, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Positive 6 100 Negative 6 100

Beckman Coulter DxC 600 series Positive 9 100 Negative 9 100

Beckman Coulter DxC 800 series Positive 6 100 Negative 6 100

Bio-Rad TOX/See Multi-Drug Screen Panel Positive 32 100 Negative 32 100

Branan Medical Corp. QuickTox Positive 8 100 Negative 8 100

Siemens Dimension Vista Positive 7 100 Negative 7 100

Innovacon Positive 7 100 Negative 7 100

Medtox Profile Series Positive 60 100 Negative 60 100

Noble Medical Split Specimen Cup Positive 13 100 Negative 13 100

Roche Integra Positive 6 100 Negative 6 100

Siemens Dimension EXL Positive 17 100 Negative 17 100

Siemens Dimension RxL Positive 6 100 Negative 6 100

Alere Triage Drugs of Abuse Panel (visual) Positive 11 100 Negative 11 100

Alere Triage TOX Drug Screen (meter) Positive 8 100 Negative 8 100

All Methods Positive 260 100 Negative 262 99

*Positve 1 1

Barbiturates, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Negative 5 100 Positive 5 100

Beckman Coulter DxC 600 series Negative 9 100 Positive 9 100

Beckman Coulter DxC 800 series Negative 6 100 Positive 6 100

Bio-Rad TOX/See Multi-Drug Screen Panel Negative 32 100 Positive 32 100

Branan Medical Corp. QuickTox Negative 8 100 Positive 8 100

Siemens Dimension Vista Negative 7 100 Positive 7 100

Medtox Profile Series Negative 59 100 Positive 59 100

Noble Medical Split Specimen Cup Negative 13 100 Positive 13 100

Vitros 5600 Negative 5 100 Positive 5 100

2014 - Chem/Endo/Tx1 Qualitative Statistics Summary

*Denotes Incorrect Response

Barbiturates, urine UD-1 N % UD-2 N %

Roche cobas Integra Negative 5 100 Positive 5 100

Siemens Dimension EXL Negative 17 100 Positive 17 100

Siemens Dimension RxL Negative 6 100 Positive 6 100

Alere Triage Drugs of Abuse Panel (visual) Negative 11 100 Positive 11 100

Alere Triage TOX Drug Screen (meter) Negative 8 100 Positive 8 100

All Methods Negative 247 100 Positive 247 100

Benzodiazepines, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Negative 7 100 Negative 7 100

Beckman Coulter DxC 600 series Negative 9 100 Negative 9 100

Beckman Coulter DxC 800 series Negative 6 100 Negative 6 100

Bio-Rad TOX/See Multi-Drug Screen Panel Negative 32 100 Negative 32 100

Branan Medical Corp. QuickTox Negative 8 100 Negative 8 100

Siemens Dimension Vista Negative 7 100 Negative 7 100

Innovacon Negative 5 100 Negative 5 100

Medtox Profile Series Negative 59 100 Negative 59 100

Noble Medical Split Specimen Cup Negative 13 100 Negative 13 100

Vitros 5600 Negative 5 100 Negative 5 100

Roche cobas Integra Negative 5 100 Negative 5 100

Siemens Dimension EXL Negative 17 100 Negative 17 100

Siemens Dimension RxL Negative 6 100 Negative 6 100

Alere Triage Drugs of Abuse Panel (visual) Negative 11 100 Negative 11 100

Alere Triage TOX Drug Screen (meter) Negative 8 100 Negative 8 100

All Methods Negative 257 100 Negative 257 100

Buprenorphine, urine UD-1 N % UD-2 N %

Medtox Profile Series Negative 30 100 Negative 30 100

Noble Medical Split Specimen Cup Negative 11 100 Negative 11 100

All Methods Negative 62 100 Negative 62 100

Cannabinoids, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Positive 7 100 Negative 7 100

Beckman Coulter DxC 600 series Positive 9 100 Negative 9 100

Beckman Coulter DxC 800 series Positive 6 100 Negative 6 100

Bio-Rad TOX/See Multi-Drug Screen Panel Positive 32 100 Negative 32 100

Branan Medical Corp. QuickTox Positive 8 100 Negative 8 100

Siemens Dimension Vista Positive 7 100 Negative 7 100

Innovacon Positive 7 100 Negative 7 100

Medtox Profile Series Positive 60 100 Negative 60 100

Noble Medical Split Specimen Cup Positive 13 100 Negative 13 100

Vitros 5600 Positive 5 100 Negative 5 100

Roche cobas Integra Positive 5 100 Negative 5 100

Siemens Dimension EXL Positive 17 100 Negative 17 100

Siemens Dimension RxL Positive 6 100 Negative 6 100

Alere Triage Drugs of Abuse Panel (visual) Positive 11 100 Negative 11 100

Alere Triage TOX Drug Screen (meter) Positive 8 100 Negative 8 100

All Methods Positive 263 100 Negative 263 100

Cocaine metabolites, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Negative 7 100 Positive 7 100

Beckman Coulter DxC 600 series Negative 9 100 Positive 9 100

Beckman Coulter DxC 800 series Negative 6 100 Positive 6 100

Bio-Rad TOX/See Multi-Drug Screen Panel Negative 32 100 Positive 32 100

Branan Medical Corp. QuickTox Negative 8 100 Positive 8 100

Siemens Dimension Vista Negative 7 100 Positive 7 100

Innovacon Negative 8 100 Positive 8 100

Medtox Profile Series Negative 60 100 Positive 60 100

*Denotes Incorrect Response

Cocaine metabolites, urine UD-1 N % UD-2 N %

Noble Medical Split Specimen Cup Negative 13 100 Positive 13 100

Siemens Dimension EXL Negative 17 100 Positive 17 100

Siemens Dimension RxL Negative 6 100 Positive 6 100

Alere Triage Drugs of Abuse Panel (visual) Negative 11 100 Positive 11 100

Alere Triage TOX Drug Screen (meter) Negative 8 100 Positive 8 100

All Methods Negative 265 100 Positive 265 100

Ethanol, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Positive 7 100 Negative 7 100

All Methods Positive 32 100 Positive 32 100

MDMA, urine UD-1 N % UD-2 N %

Bio-Rad TOX/See Multi-Drug Screen Panel Positive 28 97 Negative 29 100

*Negative 1 3

Branan Medical Corp. QuickTox Positive 6 86 Negative 7 100

1 14

Noble Medical Split Specimen Cup Positive 13 100 Negative 13 100

All Methods Positive 69 97 Negative 71 100

*Negative 2 3

Methadone, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Negative 6 100 Positive 6 100

Bio-Rad TOX/See Multi-Drug Screen Panel Negative 29 100 Positive 29 100

Branan Medical Corp. QuickTox Negative 8 100 Positive 6 75

*Negative 2 25

Medtox Profile Series Negative 56 100 Positive 55 98

*Negative 1 2

Noble Medical Split Specimen Cup Negative 13 100 Positive 13 100

Siemens Dimension EXL Negative 10 100 Positive 10 100

Alere Triage Drugs of Abuse Panel (visual) Negative 5 100 Positive 5 100

Alere Triage TOX Drug Screen (meter) Negative 5 100 Positive 5 100

All Methods Negative 190 100 Positive 184 97

*Negative 6 3

Methamphetamines, urine UD-1 N % UD-2 N %

Bio-Rad TOX/See Multi-Drug Screen Panel Positive 31 100 Negative 31 100

Branan Medical Corp. QuickTox Positive 8 100 Negative 7 88

*Positive 1 12

Medtox Profile Series Positive 56 98 Negative 57 100

*Negative 1 2

Noble Medical Split Specimen Cup Positive 13 100 Negative 13 100

All Methods Positive 145 99 Negative 145 99

*Negative 1 1 *Positive 1 1

Opiates, urine UD-1 N % UD-2 N %

Beckman Coulter AU series Positive 7 100 Negative 7 100

Beckman Coulter DxC 600 series Positive 9 100 Negative 9 100

Beckman Coulter DxC 800 series Positive 6 100 Negative 6 100

Bio-Rad TOX/See Multi-Drug Screen Panel Positive 32 100 Negative 32 100

Branan Medical Corp. QuickTox Positive 8 100 Negative 8 100

Siemens Dimension Vista Positive 7 100 Negative 7 100

Innovacon Positive 7 100 Negative 7 100

Medtox Profile Series Positive 60 100 Negative 60 100

Noble Medical Split Specimen Cup Positive 13 100 Negative 13 100

Vitros 5600 Positive 5 100 Negative 5 100

Siemens Dimension EXL Positive 17 100 Negative 17 100

Siemens Dimension RxL Positive 6 100 Negative 6 100

Alere Triage Drugs of Abuse Panel (visual) Positive 11 100 Negative 11 100

*Denotes Incorrect Response

Opiates, urine UD-1 N % UD-2 N %

Alere Triage TOX Drug Screen (meter) Positive 8 100 Negative 8 100

All Methods Positive 261 99 Negative 261 99

*Negative 2 1 *Positive 1 1

Oxycodone, urine UD-1 N % UD-2 N %

Bio-Rad TOX/See Multi-Drug Screen Panel Negative 13 100 Negative 13 100

Branan Medical Corp. QuickTox Negative 8 100 Negative 8 100

Innovacon Negative 5 83 Negative 6 100

*Positive 1 17

Medtox Profile Series Negative 58 100 Negative 58 100

Noble Medical Split Specimen Cup Negative 13 100 Negative 13 100

All Methods Negative 141 95 Negative 149 100

*Positive 8 5

Phencyclidine, urine UD-1 N % UD-2 N %

Bio-Rad TOX/See Multi-Drug Screen Panel Negative 15 100 Negative 14 93

*Positive 1 7

Branan Medical Corp. QuickTox Negative 7 100 Negative 7 100

Siemens Dimension Vista Negative 5 100 Negative 5 100

Innovacon Negative 5 100 Negative 5 100

Medtox Profile Series Negative 60 100 Negative 60 100

Siemens Dimension EXL Negative 12 100 Negative 12 100

Siemens Dimension RxL Negative 6 100 Negative 6 100

Alere Triage Drugs of Abuse Panel (visual) Negative 7 100 Negative 7 100

All Methods Negative 183 100 Negative 182 99

*Positive 1 1

Propoxyphene, urine UD-1 N % UD-2 N %

Beckman Coulter AU Series Positive 5 100 Negative 5 100

Medtox Profile Series Positive 52 98 Negative 53 100

*Negative 1 2

All Methods Positive 70 99 Negative 71 100

*Negative 1 1

Tricyclic antidepressants, urine UD-1 N % UD-2 N %

Bio-Rad TOX/See Multi-Drug Screen Panel Negative 34 97 Negative 35 100

*Positive 1 3

Innovacon Negative 5 100 Negative 5 100

Medtox Profile Series Negative 56 100 Negative 56 100

Alere Triage Drugs of Abuse Panel (visual) Negative 10 100 Negative 10 100

Alere Triage TOX Drug Screen (meter) Negative 6 100 Negative 6 100

All Methods Negative 142 99 Negative 143 100

*Positive 1 1

*Denotes Incorrect Response