10/07/16
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Catherine M. Stefanato, MD, FRCPath Consultant in Dermatopathology
St John’s Institute of Dermatology London, UK
A. ChromomycosisB. CutaneousT-celllymphomaC. HypertrophiclupusD. Squamouscellcarcinoma
Hypertrophiclupuserythematosus
• Variantofdiscoidlupuserythematosus(DLE)
• Erythematousverrucousplaques,resistanttotopicalRx
• Faceandupperlimbs
• OOenconcomitantlesionsofDLE
• MayclinicallyresembleKA/SCC
HypertrophiclupuserythematosusHistopathology
• Epidermal(pseudoepitheliomatous)hyperplasia
• OtherfeaturesofLEpresent• Vacuolarinterfacechange
• Basementmembranezonethickenning
• TransepidermaleliminaUonofelasUcfibres(butalsodescribedinKAandSCC)
• BandandclustersofCD123-posiUvecellsbelowDEJ
10/07/16
2
CD123CD123
• DrAnastasiaTherianou• DrSusieMorley• DrJaneSe=erfield