REGULATORY TOXICOLOGY AND PHARMACOLOGY 12, 311-317 (1990) Cumulative Subject Index 1 Volumes 11-12 A Absorption coefficients literature-derived, for chemicals via oral and inhalation exposure routes, 11, 237 Acceptable daily intake food additives, effect of potential high intakes, toxico- logical evaluation, 11, 3 2-Acetylaminofluorene, see N-2-Fluorenylacetamide Administrators science, relationship to public concern about chemical risk, editorial, 12, 1 Adults estimated soil ingestion, pilot study, 12, 88 Advisories fish consumption, evaluation, 12, 161 health, see Health advisories Air containing trichloroethylene, health risk assessment, 11, 24 contaminants standard by OSHA, comparison with data on chemical carcinogenesis, 12, 296 Announcements Fifth Annual Meeting of the International Society of Regulatory Toxicology and Pharmacology, Inter- national Achievement Award, 11, 101 First International Conference on Food, Nutrition, and Chemical Toxicity, Guildford, Surrey, United Kingdom, April 1991, 12, 309 International Society of Regulatory Toxicology and Pharmacology Annual Meeting, Washington D.C., October 1990, 12, 105 Sixth Annual Meeting of the International Society of Regulatory Toxicology and Pharmacology, Wash- ington D.C., October 1990, 11, 100 Asbestos fibers human risk assessment, administrative perspective, 11, 63 B Benzene sho~-termexposure limits, OSHA standard, analysis, 11,275 Benzo[a]pyrene evaluation as genetic procarcinogen, mechanistic con- sidemtions, 12, 41 Bioassay for prediction of developmental toxicity hazard potential of halogenated drinking water disinfection by- products, 11, 213 Blood, see also Plasma lead levels, relationship to soil lead from mining wastes, assessment, 11, 158 Budget method in calculation of potential high intakes of foodstuffs, use in determining acceptable daily intakes of food additives, 11, 3 G Canada drug regulation, review, 12, 214 Cancer hazard, based scheme for carcinogen classification, 12, 270 lung, role of crystalline silica: review of recent experi- mental evidence, 12, 224 risk, chlorine dioxide-disinfected water to hemodialysis patients, review, 11, 42 Caramel beverage use, acceptable daily intakes, effect of potential high intakes, toxicological evaluation, 11, 3 Carcinogenesis chemical, related data, comparison with OSHA air con- taminants standard, 12, 296 potential of food-packaging chemicals, evaluation with decision point approach, 12, 30 methidathion, evaluation (mouse), 12, 117 Carcinogens classification scheme, 12, 270 food-related, regulation in Japan, 11, 149 human risk assessment, administrative perspective, 11, 63 relevance of maximum tolerated dose, review, 11, 68 mechanistic considerations: genotoxic procarcinogens and nongenotoxic carcinogens, 12, 41 Boldface numbers indicate appropriate volume; lightface numbers indicate pagination. 311 0273-2300/90 $3.00 Copyright 1990 by Academic Press, Inc. All rights of reproduction in any form reserved.
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REGULATORY TOXICOLOGY AND PHARMACOLOGY 12, 311-317 (1990)
Cumulative Subject Index 1
Volumes 1 1 - 1 2
A
Absorption coefficients literature-derived, for chemicals via oral and inhalation
exposure routes, 11, 237 Acceptable daily intake
food additives, effect of potential high intakes, toxico- logical evaluation, 11, 3
2-Acetylaminofluorene, see N-2-Fluorenylacetamide Administrators
science, relationship to public concern about chemical risk, editorial, 12, 1
Adults estimated soil ingestion, pilot study, 12, 88
Advisories fish consumption, evaluation, 12, 161 health, see Health advisories
Air containing trichloroethylene, health risk assessment, 11,
24 contaminants standard by OSHA, comparison with data
on chemical carcinogenesis, 12, 296 Announcements
Fifth Annual Meeting of the International Society of Regulatory Toxicology and Pharmacology, Inter- national Achievement Award, 11, 101
First International Conference on Food, Nutrition, and Chemical Toxicity, Guildford, Surrey, United Kingdom, April 1991, 12, 309
International Society of Regulatory Toxicology and Pharmacology Annual Meeting, Washington D.C., October 1990, 12, 105
Sixth Annual Meeting of the International Society of Regulatory Toxicology and Pharmacology, Wash- ington D.C., October 1990, 11, 100
Asbestos fibers human risk assessment, administrative perspective, 11,
with decision point approach, 12, 30 produced by genetic modification, safety assurance, In-
ternational Food Biotechnology Council report
editorial, 12, 213, vii general legal and regulatory issues, 12, S159 introduction, 12, S1 methods of genetic modification and their use, 12,
$79 safety evaluation of
foods and food ingredients derived from micro- organisms, 12, S114
single chemical entities and simple chemically de- fined mixtures, 12, S129
whole foods and other complex mixtures, 12, S136 variability in composition of traditional foods: nu-
trients, microorganisms, and toxicants, 12, S11 related carcinogens, regulation in Japan, 11, 149 safety, relationship to public interest groups, 12, 263
Food additives acceptable daily intakes, effect of potential high intakes,
EPA lifetime health advisory and water quality criteria, comparison, 11, 118
I
Ingestion soil by adults, estimates, pilot study, 12, 88
International Food Biotechnology Council reports Biotechnologies and Food: A Summary of Major Issues
Regarding Safety Assurance, 12, 96 Biotechnology and Food: Assuring Safety of Foods Pro-
duced by Genetic Modification editorial, 12, 213, vii general legal and regulatory issues, 12, S159 introduction, 12, S1 methods of genetic modification and their use, 12,
$79 safety evaluation of
foods and food ingredients derived from micro- organisms, 12, S 114
single chemical entities and simple chemically de- fined mixtures, 12, S129
whole foods and other complex mixtures, 12, S 136 variability in composition of traditional foods: nu-
trients, microorganisms, and toxicants, 12, S11 Interspecies extrapolations
from animals to humans dose-related drug toxicity, review of different methods,
12, 107 respiratory effects of toluene diisocyanate, use in for-
mulation of acceptable exposure limits, 12, 53
role in uncertainty in health risk assessment, analysis, 11, 191
toxicologic: utility and futility of plasma levels of test substance, 12, 137
Japan regulatory policy on food-related carcinogens based on
risk assessment, 11, 149
L
Lead from mining wastes, content in soil, relationship to blood
lead, assessment, 11, 158 Legal principles
interaction with scientific principles, relationship to regulatory definitions of risk, 11, 201
nization, 12, 179 Japanese, on food-related carcinogens, role of risk as-
sessment, 11, 149 for published cigarette tar yield, role of public perception
of data, 12, 64 threshold-based, for indirect food additives migrating
from food packaging materials, workshop report, 12, 2
Regulatory standards for drugs: publication of 22nd revision of United States
Pharmacopeia and 17th edition of National For- mulary, editorial, 11, 103
Respiratory system, see also Lung different effects of toluene diisocyanate in animals, as
basis for establishment of acceptable exposure lim- its, 12, 53
Risk chemical, public concern over, relationship to science
administrators, editorial, 12, 1 legal regulatory definitions: interaction of scientific and
legal principles, 11,201 Risk assessment
carcinogens, for humans administrative perspective, 11, 63 relevance of maximum tolerated dose, review, 11, 68
environmental introductions of genetically engineered microorganisms, efficacy of l a c Z Y marker system as tracking tool, small-scale field test, 11,253
fish consumption, 12, 161 health, see Health risk assessment and management, toxicological, associated data base
selection, 11, 308
316 CUMULATIVE SUBJECT INDEX
in regulation of food-related carcinogens in Japan, 11, 149
Risk management and assessment, toxicological, associated data base se-
lection, 11,308
Structure-activity relationships in evaluation of carcinogenic potential of food-packaging
chemicals, 12, 30
1"
Saccharin evaluation as nongenotoxic carcinogen, mechanistic
considerations, 12, 41 Safety assessment
drug candidates importance of pharmacokinetic and receptor studies,
11,288 role of pharmacological profiling, 12, 238
food-packaging chemicals, use of decision point ap- proach, 12, 30
Safety assurance foods produced by genetic modification, International
Food Biotechnology Council report editorial, 12, 213, vii general legal and regulatory issues, 12, S159 introduction, 12, S1 methods of genetic modification and their use, 12,
$79 safety evaluation of
foods and food ingredients derived from micro- organisms, 12, S114
single chemical entities and simple chemically de- fined mixtures, 12, S129
whole foods and other complex mixtures, 12, S136 variability in composition of traditional foods: nu-
trients, microorganisms, and toxicants, 12, S11 major issues regarding biotechnology and food produc-
tion, International Food Biotechnology Council report, 12, 96
Safety factors approach to deriving community exposure guidelines
from no-observed-adverse-effect levels, 11,314 Scientific principles
interaction with legal principles, relationship to regu- latory definitions of risk, 11,201
Silica crystalline, role in lung cancer: review of recent exper-
imental evidence, 12, 224 Skin irritation
testing with Hill Top chamber and gauze patch, com- parison (human, rabbit), 12, 127
Soil adult ingestion estimates, pilot study, 12, 88 lead content from mining wastes, relationship to blood
lead, assessment, 11, 158
Tar cigarette yields, public perceptions of, implications for
regulation, 12, 64 -nicotine ratio, potential role in cigarette classification,
analysis, 12, 253 TCDD, see Dioxin Testing
Hill Top chamber and gauze patch, for skin irritation, comparison (human, rabbit), 12, 127
toxicity, see Toxicity testing 2,3,7,8-Tetrachlorodibenzo-p-dioxin, see Dioxin Toluene diisocyanate
acceptable exposure limits based on different airway ef- fects (guinea pig, mouse), 12, 53
Toxicity developmental, see Developmental toxicity drug dosage-related, extrapolation from animals to hu-
mans, review of different methods, 12, 107 interspecies extrapolations: utility and futility of plasma
levels of test substance, 12, 137 no-observed-adverse-effect levels, derived community
exposure guidelines, 1 l, 314 2,4,6-trinitrotoluene, related water quality criteria pro-
posal, l l , 104 Toxicity testing
acute, chemicals in nonlethal dose range: criteria based on clinical assessment of adverse effects, 12, 69
animal-based, limitations in drug safety evaluation, I I , 288
pharmaceuticals, international guideline harmonization, 12, 179
preclinical studies of antiviral drugs in treatment of non- life-threatening diseases, review, l l, 81
Toxicology evaluation of food additives: budget method, 11, 3
Trichloroacetic acid developmental toxicity hazard potential, prediction by
in vitro hydra assay, l l , 213 Trichloroacetonitrile
developmental toxicity hazard potential, prediction by in vitro hydra assay, 11, 213
1,1,1-Trichloroethane environmental exposure, health risk assessment, 1 l, 90
Trichloroethylene environmental exposure, health risk assessment, l l , 24
2,4,6-Trichlorophenol developmental toxicity hazard potential, prediction by
in vitro hydra assay, I l , 213
CUMULATIVE SUBJECT INDEX 317
2,4,6-Trinitrotoluene EPA health advisories and water quality criteria, com-
parison, II, t 14 water quality criteria proposal, 11, 104
Uncertainty in hazard assessment, compensatory actions, l l , 123 in health risk assessment, analysis, 11, 191
United States Pharmacopeia publication of 22nd revision, editorial, 11, 103
W
Water chlorine dioxide disinfection, risk for hemodialysis pa-
tients, review, 11, 42 drinking, s e e Drinking water quality criteria
for hexahydro-l,3,5-trinitro-l,3,5-triazine, compar- ison with EPA lifetime health advisory, 11, 118
for 2,4,6qrinitrotoluene comparisorz with EPA health advisories, l l, 114 proposal, 11, 104
Statement of Qwnership, management, and etr required by the Ac t o l October Z3. 1967, Section #369, T i t le 39, United geate~ Code: e l
REGULATORY TOXICOLOGY AND PHARMACOLOGY
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