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DNA Topoisomerases - Center for Cancer Research · Levofloxacin. Interfacial inhibition....

Date post: 10-Mar-2019
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DNA Topoisomerases
Transcript

DNA Topoisomerases

Review

DNA Topoisomerases And

Cancer

Topoisomerases and TOP

Genes in Humans

Humans vs. Escherichia Coli

Humans vs. Escherichia Coli

Human Topoisomerases

Comparisons

Differential geometry

Top 1

Relaxation of DNA

Top1

The Two Human Top 1s

Camptothecin

Camptothecins

Interfacial inhibitor

Mutation

Why New Top1 Inhibitors?

Pharmacological Limitations of

Camptothecins:

Indenoisoquinolines

Targeted delivery

Top2

Two Top2 enzymes

Top2

Transcription

DNA replication

Top2 drugs

Etoposide

Levofloxacin

Interfacial inhibition

Topoisomerase drugs

Top 3

Decatenation

Top-3beta

Top3A and Top3B

Topoisomerases

Topoisomerases and disease

Replicative DNA damage

DNA damage

DNA damage

Human diseases

Covalent complexes

Topoisomerase

Acknowledgements


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